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Aliases for MYO1B Gene

Aliases for MYO1B Gene

  • Myosin IB 2 3
  • Myosin I Alpha 3 4
  • MMI-Alpha 3 4
  • MYH-1c 3 4
  • MMIa 3 4
  • MYO1B Variant Protein 3
  • Myosin-I Alpha 3
  • Myosin-Ib 3
  • Myr1 3

External Ids for MYO1B Gene

Previous GeneCards Identifiers for MYO1B Gene

  • GC02P190429
  • GC02P190830
  • GC02P192091
  • GC02P192312
  • GC02P191935
  • GC02P191818
  • GC02P183969

Summaries for MYO1B Gene

GeneCards Summary for MYO1B Gene

MYO1B (Myosin IB) is a Protein Coding gene. Diseases associated with MYO1B include amebiasis. Among its related pathways are RhoGDI Pathway and PAK Pathway. GO annotations related to this gene include calmodulin binding and motor activity. An important paralog of this gene is MYO1D.

UniProtKB/Swiss-Prot for MYO1B Gene

  • Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.

Gene Wiki entry for MYO1B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO1B Gene

Genomics for MYO1B Gene

Regulatory Elements for MYO1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MYO1B Gene

Chromosome:
2
Start:
191,245,185 bp from pter
End:
191,425,389 bp from pter
Size:
180,205 bases
Orientation:
Plus strand

Genomic View for MYO1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYO1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO1B Gene

Proteins for MYO1B Gene

  • Protein details for MYO1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43795-MYO1B_HUMAN
    Recommended name:
    Unconventional myosin-Ib
    Protein Accession:
    O43795
    Secondary Accessions:
    • O43794
    • Q7Z6L5

    Protein attributes for MYO1B Gene

    Size:
    1136 amino acids
    Molecular mass:
    131985 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MYO1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO1B Gene

Proteomics data for MYO1B Gene at MOPED

Post-translational modifications for MYO1B Gene

  • Ubiquitination at Lys 588, Lys 952, and Lys 986
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for MYO1B

No data available for DME Specific Peptides for MYO1B Gene

Domains & Families for MYO1B Gene

Gene Families for MYO1B Gene

Suggested Antigen Peptide Sequences for MYO1B Gene

Graphical View of Domain Structure for InterPro Entry

O43795

UniProtKB/Swiss-Prot:

MYO1B_HUMAN :
  • Contains 6 IQ domains.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • Contains 6 IQ domains.
  • Contains 1 myosin motor domain.
  • Contains 1 TH1 (class I myosin tail homology) domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO1B: view

Function for MYO1B Gene

Molecular function for MYO1B Gene

UniProtKB/Swiss-Prot Function:
Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.

Gene Ontology (GO) - Molecular Function for MYO1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000146 microfilament motor activity ISS --
GO:0003774 motor activity --
GO:0005515 protein binding --
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding ISS --
genes like me logo Genes that share ontologies with MYO1B: view

Phenotypes for MYO1B Gene

GenomeRNAi human phenotypes for MYO1B:
genes like me logo Genes that share phenotypes with MYO1B: view

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYO1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MYO1B Gene

Localization for MYO1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO1B Gene COMPARTMENTS Subcellular localization image for MYO1B gene
Compartment Confidence
cytoskeleton 5
endosome 5
extracellular 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for MYO1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005769 early endosome IDA 16219689
GO:0005884 actin filament IDA 16219689
GO:0005886 plasma membrane ISS --
GO:0005903 brush border ISS --
genes like me logo Genes that share ontologies with MYO1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYO1B Gene

Pathways & Interactions for MYO1B Gene

genes like me logo Genes that share pathways with MYO1B: view

Gene Ontology (GO) - Biological Process for MYO1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006892 post-Golgi vesicle-mediated transport IMP 21666684
GO:0007015 actin filament organization IMP 21666684
GO:0008152 metabolic process IEA --
GO:0030048 actin filament-based movement ISS --
GO:0051017 actin filament bundle assembly ISS --
genes like me logo Genes that share ontologies with MYO1B: view

No data available for SIGNOR curated interactions for MYO1B Gene

Drugs & Compounds for MYO1B Gene

No Compound Related Data Available

Transcripts for MYO1B Gene

Unigene Clusters for MYO1B Gene

Myosin IB:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYO1B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYO1B Gene

No ASD Table

Relevant External Links for MYO1B Gene

GeneLoc Exon Structure for
MYO1B
ECgene alternative splicing isoforms for
MYO1B

Expression for MYO1B Gene

mRNA expression in normal human tissues for MYO1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYO1B Gene

This gene is overexpressed in Liver (x7.9).

Protein differential expression in normal tissues from HIPED for MYO1B Gene

This gene is overexpressed in Nasal epithelium (9.2), Bone marrow mesenchymal stem cell (9.1), Islet of Langerhans (7.2), Bone (6.2), and Gallbladder (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYO1B Gene



SOURCE GeneReport for Unigene cluster for MYO1B Gene Hs.439620

genes like me logo Genes that share expression patterns with MYO1B: view

Protein tissue co-expression partners for MYO1B Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MYO1B Gene

Orthologs for MYO1B Gene

This gene was present in the common ancestor of animals.

Orthologs for MYO1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYO1B 35
  • 92.96 (n)
  • 98.06 (a)
MYO1B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYO1B 35
  • 92.25 (n)
  • 98.5 (a)
MYO1B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo1b 35
  • 89.88 (n)
  • 97.89 (a)
Myo1b 16
Myo1b 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYO1B 35
  • 99.65 (n)
  • 100 (a)
MYO1B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myo1b 35
  • 89.61 (n)
  • 97.45 (a)
oppossum
(Monodelphis domestica)
Mammalia MYO1B 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYO1B 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYO1B 35
  • 83.66 (n)
  • 94.28 (a)
MYO1B 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYO1B 36
  • 90 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii myo1b 35
  • 73.13 (n)
  • 82.61 (a)
wufb39h10 35
myo1b 36
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004403 35
  • 47.69 (n)
  • 39.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta Myo95E 35
  • 48 (n)
  • 38.75 (a)
Myo95E 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for MYO1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO1B Gene

ENSEMBL:
Gene Tree for MYO1B (if available)
TreeFam:
Gene Tree for MYO1B (if available)

Paralogs for MYO1B Gene

Paralogs for MYO1B Gene

genes like me logo Genes that share paralogs with MYO1B: view

Variants for MYO1B Gene

Sequence variations from dbSNP and Humsavar for MYO1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs11261 -- 191,423,967(-) AGGAG(G/T)CGCCA utr-variant-3-prime
rs764980 -- 191,261,739(+) CTTTA(A/C/G)AACCT intron-variant, upstream-variant-2KB
rs897196 -- 191,280,606(+) AAACC(A/G)TTGAC intron-variant
rs897197 -- 191,281,456(+) GACAG(G/T)CTCCG intron-variant
rs921737 -- 191,286,097(+) TATTC(C/T)CCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO1B Gene

Variant ID Type Subtype PubMed ID
esv1058530 CNV Insertion 17803354
nsv3084 CNV Insertion 18451855

Variation tolerance for MYO1B Gene

Residual Variation Intolerance Score: 2.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYO1B Gene

HapMap Linkage Disequilibrium report
MYO1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO1B Gene

Disorders for MYO1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYO1B Gene - From: DISEASES

Disorder Aliases PubMed IDs
amebiasis
  • amoebiasis
- elite association
Search MYO1B in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYO1B

Genetic Association Database (GAD)
MYO1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO1B
genes like me logo Genes that share disorders with MYO1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYO1B Gene

Publications for MYO1B Gene

  1. Self-organizing actin waves that simulate phagocytic cup structures. (PMID: 20298542) Gerisch G. (PMC Biophys 2010) 23 67
  2. The three-dimensional dynamics of actin waves, a model of cytoskeletal self-organization. (PMID: 19348770) Bretschneider T. … Gerisch G. (Biophys. J. 2009) 23 67
  3. Actin-cytoskeleton dynamics in non-monotonic cell spreading. (PMID: 19262103) Heinrich D. … Gerisch G. (Cell Adh Migr 2008) 23 67
  4. Host tissue invasion by Entamoeba histolytica is powered by motility and phagocytosis. (PMID: 16380326) LabruyA"re E. … GuillAcn N. (Arch. Med. Res. 2006) 23 67
  5. Loop 1 of transducer region in mammalian class I myosin, Myo1b, modulates actin affinity, ATPase activity, and nucleotide access. (PMID: 15980431) Clark R. … Coluccio L.M. (J. Biol. Chem. 2005) 23 67

Products for MYO1B Gene

Sources for MYO1B Gene

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