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MYO1B Gene

protein-coding   GIFtS: 58
GCID: GC02P192091

Myosin IB

  See MYO1B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin IB1 2     MYO1B Variant Protein2
Myosin I Alpha2 3     myosin-Ib2
MMI-alpha2 3     Myosin-I Alpha2
MMIa2 3     myr12
MYH-1c2 3     Unconventional Myosin-Ib2

External Ids:    HGNC: 75961   Entrez Gene: 44302   Ensembl: ENSG000001286417   OMIM: 6065375   UniProtKB: O437953   

Export aliases for MYO1B gene to outside databases

Previous GC identifers: GC02P190429 GC02P190830 GC02P192312 GC02P191935 GC02P191818 GC02P183969


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYO1B Gene:
MYO1B (myosin IB) is a protein-coding gene. Diseases associated with MYO1B include amebiasis. GO annotations related to this gene include actin binding and phosphatidylinositol-4,5-bisphosphate binding. An important paralog of this gene is MYO1D.

UniProtKB/Swiss-Prot: MYO1B_HUMAN, O43795
Function: Motor protein that may participate in process critical to neuronal development and function such as cell
migration, neurite outgrowth and vesicular transport (By similarity)

Gene Wiki entry for MYO1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYO1B gene promoter:
         AML1a   Lmo2   RelA   CUTL1   NF-kappaB   Evi-1   AREB6   Sox9   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYO1B promoter sequence
   Search Chromatin IP Primers for MYO1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYO1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12-q34   Ensembl cytogenetic band:  2q32.3   HGNC cytogenetic band: 2q12-q34

MYO1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYO1B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P192091:  view genomic region     (about GC identifiers)

Start:
192,109,911 bp from pter      End:
192,290,115 bp from pter
Size:
180,205 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MYO1B_HUMAN, O43795 (See protein sequence)
Recommended Name: Unconventional myosin-Ib  
Size: 1136 amino acids; 131985 Da
Caution: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1
(MYH1)
Secondary accessions: O43794 Q7Z6L5
Alternative splicing: 2 isoforms:  O43795-1   O43795-2   

Explore the universe of human proteins at neXtProt for MYO1B: NX_O43795

Explore proteomics data for MYO1B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys588, Lys952, Lys986
  • Modification sites at PhosphoSitePlus

  • See MYO1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001123630.1  NP_001155291.1  NP_036355.2  

    ENSEMBL proteins: 
     ENSP00000401324   ENSP00000341903   ENSP00000376132   ENSP00000306382   ENSP00000399459  
     ENSP00000388140   ENSP00000387610   ENSP00000376130   ENSP00000408454   ENSP00000391442  

    MYO1B Human Recombinant Protein Products:

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    Novus Biologicals MYO1B Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYO1B

     
    Search eBioscience for Proteins for MYO1B 

     
    antibodies-online proteins for MYO1B (3 products) 

     
    antibodies-online peptides for MYO1B

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    antibodies-online antibodies for MYO1B (15 products) 

    MYO1B Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MYOI: Myosins / Myosin superfamily : Class I

    4 InterPro protein domains:
     IPR010926 Myosin_tail_2
     IPR027417 P-loop_NTPase
     IPR000048 IQ_motif_EF-hand-BS
     IPR001609 Myosin_head_motor_dom

    Graphical View of Domain Structure for InterPro Entry O43795

    ProtoNet protein and cluster: O43795

    2 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB010926 Myosin tail 2


    UniProtKB/Swiss-Prot: MYO1B_HUMAN, O43795
    Similarity: Contains 6 IQ domains
    Similarity: Contains 1 myosin head-like domain


    Find genes that share domains with MYO1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYO1B_HUMAN, O43795
    Function: Motor protein that may participate in process critical to neuronal development and function such as cell
    migration, neurite outgrowth and vesicular transport (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000146microfilament motor activity ISS--
    GO:0003774motor activity ----
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
    GO:0005516calmodulin binding IEA--
         
    Find genes that share ontologies with MYO1B           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MYO1B

    miRNA
    Products:
        
    miRTarBase miRNAs that target MYO1B:
    hsa-mir-1 (MIRT023559), hsa-mir-378a-5p (MIRT043983)

    Block miRNA regulation of human, mouse, rat MYO1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYO1B (see all 22):
    hsa-miR-137 hsa-miR-4328 hsa-miR-520d-5p hsa-miR-25 hsa-miR-340 hsa-miR-29b-1* hsa-miR-570 hsa-miR-223
    SwitchGear 3'UTR luciferase reporter plasmidMYO1B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MYO1B
    Predesigned siRNA for gene silencing in human, mouse, rat MYO1B

    Gene Editing
    Products:
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): MYO1B (NM_012223)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYO1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYO1B

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton3
    cytosol3
    endosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005886plasma membrane ISS--
    GO:0005903brush border ISS--
    GO:0016459myosin complex IEA--
    GO:0030175filopodium ISS--

    Find genes that share ontologies with MYO1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYO1B About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    wtCFTR and delta508 traffic Clathrin coated vesicles formation norm and CF 0.35
    Transport Clathrin coated vesicle cycle0.66
    2PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    3Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35
    4RhoGDI Pathway
    Fc-GammaR-Mediated Phagocytosis in Macrophages0.33
    RhoGDI Pathway0.33
    5ERK Signaling
    ILK Signaling0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYO1B (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions

    2 GeneGo (Thomson Reuters) Pathways for MYO1B
        wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
    Transport Clathrin-coated vesicle cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYO1B
    Interactions:

        Search GeneGlobe Interaction Network for MYO1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYO1B (O437952, 3 ENSP000003063824) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RIPK3Q9Y5722, 3MINT-49101 I2D: score=2 
    MAP3K3Q997592, 3, ENSP000003549274MINT-48412 I2D: score=2 STRING: ENSP00000354927
    BRF2Q9HAW03, ENSP000002206594I2D: score=2 STRING: ENSP00000220659
    EIF4A2Q142403, ENSP000003263814I2D: score=2 STRING: ENSP00000326381
    CIAO1O760713, ENSP000004182874I2D: score=1 STRING: ENSP00000418287
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ISS--
    GO:0030048actin filament-based movement ISS--
    GO:0051017actin filament bundle assembly ISS--

    Find genes that share ontologies with MYO1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYO1B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYO1B gene (3 alternative transcripts): 
    NM_001130158.1  NM_001161819.1  NM_012223.3  

    Unigene Cluster for MYO1B:

    Myosin IB
    Hs.439620  [show with all ESTs]
    Unigene Representative Sequence: NM_001130158
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418908 ENST00000339514(uc002usq.2) ENST00000392318(uc010fsg.2)
    ENST00000304164(uc002usr.2) ENST00000438652 ENST00000451437(uc002uss.1)
    ENST00000471904 ENST00000420448 ENST00000392316(uc002usu.2) ENST00000496992
    ENST00000494129(uc002ust.1) ENST00000490069 ENST00000461714 ENST00000427152
    ENST00000439065
    miRNA
    Products:
         
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    Selected qRT-PCR Assays for microRNAs that regulate MYO1B (see all 22):
    hsa-miR-137 hsa-miR-4328 hsa-miR-520d-5p hsa-miR-25 hsa-miR-340 hsa-miR-29b-1* hsa-miR-570 hsa-miR-223
    SwitchGear 3'UTR luciferase reporter plasmidMYO1B 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat MYO1B
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MYO1B (NM_012223)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYO1B
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MYO1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYO1B
      QuantiTect SYBR Green Assays in human, mouse, rat MYO1B
      QuantiFast Probe-based Assays in human, mouse, rat MYO1B

    Additional mRNA sequence: 

    AB290176.1 AJ001381.1 AJ001382.1 AK000160.1 AK074978.1 BC021665.1 BC053558.1 BC060849.1 
    L29138.1 

    22 DOTS entries:

    DT.444111  DT.95137793  DT.95101184  DT.97776691  DT.95137783  DT.214073  DT.92048517  DT.91658169 
    DT.91747299  DT.100800322  DT.120978396  DT.97804211  DT.97860730  DT.100788223  DT.120978312  DT.120978391 
    DT.91878821  DT.91905287  DT.95171239  DT.100734988  DT.100788222  DT.91931186 

    Selected AceView cDNA sequences (see all 320):

    AI674284 BM765759 AI468488 AL045193 BG616501 BM765783 BC053558 BF061446 
    BE671902 NM_012223 CB156012 BU508861 AI343466 AW069715 AI183272 AW085787 
    BP873412 BM682047 CA415531 BM745865 AA576617 BQ002392 N67893 W24806 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYO1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCAAAATT
    MYO1B Expression
    About this image


    MYO1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Mature B-Cells Peripheral Blood
     
     Liver (Hepatobiliary System)
             Mesothelial Cells Hepatic Mesenchyme
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen
     
     Lung (Respiratory System)
    MYO1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYO1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.439620
        Custom PCR Arrays for MYO1B
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat MYO1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MYO1B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myo1b1 , 5 myosin IB1, 5 89.88(n)1
    97.89(a)1
      1 (26.58 cM)5
    179121  NM_001161817.11  NP_001155289.11 
     517497655 
    chicken
    (Gallus gallus)
    Aves MYO1B1 myosin IB 83.66(n)
    94.28(a)
      424045  XM_004942574.1  XP_004942631.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYO1B6
    myosin IB
    90(a)
    1 ↔ 1
    2(133931068-134045630)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb39h102 Transcribed sequence with weak similarity to protein more 78.1(n)    AI657920.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Myo95E1 Myosin 95E 48(n)
    38.75(a)
      2768680  NM_001032037.2  NP_001027208.1 
    rice
    (Oryza sativa)
    Liliopsida NM_191733.12   -- 73.5(n)    NM_191733.1 


    ENSEMBL Gene Tree for MYO1B (if available)
    TreeFam Gene Tree for MYO1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYO1B gene
    MYO1D2  MYO15A2  MYO1C2  MYO1A2  MYO1F2  MYO1G2  MYO1E2  MYO15B2  
    MYO1H2  MYO192  
    Selected SIMAP similar genes for MYO1B using alignment to 10 protein entries:     MYO1B_HUMAN (see all proteins) (see all similar genes):
    MYO1A    MYO1D    MYO9A    MYO9B    MYO5C    MYO1C
    MYO1G    MYO1E    MYO3B    DKFZp686A01173    MYO3A    MYO19
    FLJ00395    MYO1F variant protein    MYO10    MYH9    MYO15A    MYH11

    Find genes that share paralogs with MYO1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYO1B (see all 3585)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0141134
    A melanoma patient4--see VAR_0141132 E K mis40--------
    VAR_0360084
    A colorectal cancer sample4--see VAR_0360082 V I mis40--------
    VAR_0360074
    A colorectal cancer sample4--see VAR_0360072 V G mis40--------
    rs739815171,2
    C--192108123(+) AGTCTA/GACACA 2 -- us2k12Minor allele frequency- G:0.11WA 120
    rs1466464051,2
    --192108220(+) GGTAGC/TGTGCT 2 -- us2k10--------
    rs1864555701,2
    --192108221(+) GTAGTA/GTGCTT 2 -- us2k10--------
    rs1909433401,2
    --192108224(+) GTGTGC/TTTGAT 2 -- us2k10--------
    rs1163306611,2
    F--192108322(+) GATGAC/TAATCT 3 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1821980621,2
    --192108440(+) AGCTCA/GCCAAC 3 -- us2k10--------
    rs1400140771,2
    C--192108451(+) TCACAC/TGCTTG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for MYO1B (192109911 - 192290115 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MYO1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1058530CNV Insertion17803354
    nsv3084CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606537    OMIM disorders: --

    1 disease for MYO1B:    
    About MalaCards
    amebiasis

    1 disease from the University of Copenhagen DISEASES database for MYO1B:
    Amebiasis

    Find genes that share disorders with MYO1B           About GenesLikeMe

    Genetic Association Database (GAD): MYO1B

    Export disorders for MYO1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYO1B gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with MYO1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PubMed id 22001757)1, 4 Chambers J.C....Kooner J.S. (Nat. Genet. 2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. (PubMed id 8022818)1, 3 Bement W.M.... Mooseker M.S. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    4. Identification, characterization and cloning of myr 1, a mammalian myosin-I. (PubMed id 8449985)1, 3 Ruppert C....BAohler M. (J. Cell Biol. 1993)
    5. Myosin Ib modulates the morphology and the protein transport within multi-vesicular sorting endosomes. (PubMed id 16219689)1, 9 Salas-Cortes L....Coudrier E. (J. Cell. Sci. 2005)
    6. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    7. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    8. Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)1 Chuang J.Y....Hung J.J. (Oncogene 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4430 HGNC: 7596 AceView: MYO1B Ensembl:ENSG00000128641 euGenes: HUgn4430
    ECgene: MYO1B H-InvDB: MYO1B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYO1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MYO1B gene:
    Search GeneIP for patents involving MYO1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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