Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MYO1B Gene

Aliases for MYO1B Gene

  • Myosin IB 2 3 5
  • Myosin I Alpha 3 4
  • MMI-Alpha 3 4
  • MYH-1c 3 4
  • MMIa 3 4
  • MYO1B Variant Protein 3
  • Myosin-I Alpha 3
  • Myosin-Ib 3
  • Myr1 3

External Ids for MYO1B Gene

Previous GeneCards Identifiers for MYO1B Gene

  • GC02P190429
  • GC02P190830
  • GC02P192091
  • GC02P192312
  • GC02P191935
  • GC02P191818
  • GC02P183969

Summaries for MYO1B Gene

GeneCards Summary for MYO1B Gene

MYO1B (Myosin IB) is a Protein Coding gene. Diseases associated with MYO1B include glass syndrome and amebiasis. Among its related pathways are Integrin Pathway and ERK Signaling. GO annotations related to this gene include calmodulin binding and motor activity. An important paralog of this gene is MYO1D.

UniProtKB/Swiss-Prot for MYO1B Gene

  • Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.

Gene Wiki entry for MYO1B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO1B Gene

Genomics for MYO1B Gene

Regulatory Elements for MYO1B Gene

Promoters for MYO1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MYO1B on UCSC Golden Path with GeneCards custom track

Genomic Location for MYO1B Gene

Chromosome:
2
Start:
191,245,185 bp from pter
End:
191,425,389 bp from pter
Size:
180,205 bases
Orientation:
Plus strand

Genomic View for MYO1B Gene

Genes around MYO1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO1B Gene

Proteins for MYO1B Gene

  • Protein details for MYO1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43795-MYO1B_HUMAN
    Recommended name:
    Unconventional myosin-Ib
    Protein Accession:
    O43795
    Secondary Accessions:
    • O43794
    • Q7Z6L5

    Protein attributes for MYO1B Gene

    Size:
    1136 amino acids
    Molecular mass:
    131985 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MYO1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO1B Gene

Proteomics data for MYO1B Gene at MOPED

Post-translational modifications for MYO1B Gene

  • Ubiquitination at Lys 588, Lys 952, and Lys 986
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for MYO1B

No data available for DME Specific Peptides for MYO1B Gene

Domains & Families for MYO1B Gene

Gene Families for MYO1B Gene

Suggested Antigen Peptide Sequences for MYO1B Gene

Graphical View of Domain Structure for InterPro Entry

O43795

UniProtKB/Swiss-Prot:

MYO1B_HUMAN :
  • Contains 6 IQ domains.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • Contains 6 IQ domains.
  • Contains 1 myosin motor domain.
  • Contains 1 TH1 (class I myosin tail homology) domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO1B: view

Function for MYO1B Gene

Molecular function for MYO1B Gene

UniProtKB/Swiss-Prot Function:
Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.

Gene Ontology (GO) - Molecular Function for MYO1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000146 microfilament motor activity ISS --
GO:0003774 motor activity IEA --
GO:0005524 ATP binding IEA,ISS --
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding ISS --
GO:0051015 actin filament binding IMP 21666684
genes like me logo Genes that share ontologies with MYO1B: view

Phenotypes for MYO1B Gene

GenomeRNAi human phenotypes for MYO1B:
genes like me logo Genes that share phenotypes with MYO1B: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYO1B Gene

Localization for MYO1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO1B Gene COMPARTMENTS Subcellular localization image for MYO1B gene
Compartment Confidence
cytoskeleton 5
endosome 5
extracellular 5
plasma membrane 5
cytosol 3
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MYO1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005769 early endosome IDA 16219689
GO:0005886 plasma membrane ISS --
GO:0005903 brush border ISS --
GO:0016459 myosin complex IEA --
genes like me logo Genes that share ontologies with MYO1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYO1B Gene

Pathways & Interactions for MYO1B Gene

genes like me logo Genes that share pathways with MYO1B: view

Gene Ontology (GO) - Biological Process for MYO1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006892 post-Golgi vesicle-mediated transport IMP 21666684
genes like me logo Genes that share ontologies with MYO1B: view

No data available for SIGNOR curated interactions for MYO1B Gene

Drugs & Compounds for MYO1B Gene

No Compound Related Data Available

Transcripts for MYO1B Gene

Unigene Clusters for MYO1B Gene

Myosin IB:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYO1B Gene

No ASD Table

Relevant External Links for MYO1B Gene

GeneLoc Exon Structure for
MYO1B
ECgene alternative splicing isoforms for
MYO1B

Expression for MYO1B Gene

mRNA expression in normal human tissues for MYO1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYO1B Gene

This gene is overexpressed in Liver (x7.9).

Protein differential expression in normal tissues from HIPED for MYO1B Gene

This gene is overexpressed in Nasal epithelium (9.2), Bone marrow mesenchymal stem cell (9.1), Islet of Langerhans (7.2), Bone (6.2), and Gallbladder (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYO1B Gene



SOURCE GeneReport for Unigene cluster for MYO1B Gene Hs.439620

genes like me logo Genes that share expression patterns with MYO1B: view

Protein tissue co-expression partners for MYO1B Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MYO1B Gene

Orthologs for MYO1B Gene

This gene was present in the common ancestor of animals.

Orthologs for MYO1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYO1B 35
  • 92.96 (n)
  • 98.06 (a)
MYO1B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYO1B 35
  • 92.25 (n)
  • 98.5 (a)
MYO1B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo1b 35
  • 89.88 (n)
  • 97.89 (a)
Myo1b 16
Myo1b 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYO1B 35
  • 99.65 (n)
  • 100 (a)
MYO1B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myo1b 35
  • 89.61 (n)
  • 97.45 (a)
oppossum
(Monodelphis domestica)
Mammalia MYO1B 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYO1B 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYO1B 35
  • 83.66 (n)
  • 94.28 (a)
MYO1B 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYO1B 36
  • 90 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii myo1b 35
  • 73.13 (n)
  • 82.61 (a)
wufb39h10 35
myo1b 36
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004403 35
  • 47.69 (n)
  • 39.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta Myo95E 35
  • 48 (n)
  • 38.75 (a)
Myo95E 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for MYO1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO1B Gene

ENSEMBL:
Gene Tree for MYO1B (if available)
TreeFam:
Gene Tree for MYO1B (if available)

Paralogs for MYO1B Gene

Paralogs for MYO1B Gene

genes like me logo Genes that share paralogs with MYO1B: view

Variants for MYO1B Gene

Sequence variations from dbSNP and Humsavar for MYO1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_014113 A melanoma patient
VAR_036007 A colorectal cancer sample
VAR_036008 A colorectal cancer sample
rs11261 -- 191,423,967(-) AGGAG(G/T)CGCCA utr-variant-3-prime
rs764980 -- 191,261,739(+) CTTTA(A/C/G)AACCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MYO1B Gene

Variant ID Type Subtype PubMed ID
esv1058530 CNV Insertion 17803354
nsv3084 CNV Insertion 18451855

Variation tolerance for MYO1B Gene

Residual Variation Intolerance Score: 2.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYO1B Gene

HapMap Linkage Disequilibrium report
MYO1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO1B Gene

Disorders for MYO1B Gene

MalaCards: The human disease database

(2) MalaCards diseases for MYO1B Gene - From: DISEASES

Disorder Aliases PubMed IDs
glass syndrome
  • chromosome 2q32-q33 deletion syndrome
amebiasis
  • amoebiasis
- elite association - COSMIC cancer census association via MalaCards
Search MYO1B in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYO1B

Genetic Association Database (GAD)
MYO1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO1B
genes like me logo Genes that share disorders with MYO1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYO1B Gene

Publications for MYO1B Gene

  1. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PMID: 22001757) Chambers J.C. … Kooner J.S. (Nat. Genet. 2011) 3 48 67
  2. Myosin Ib modulates the morphology and the protein transport within multi-vesicular sorting endosomes. (PMID: 16219689) Salas-Cortes L. … Coudrier E. (J. Cell. Sci. 2005) 3 23
  3. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. (PMID: 8022818) Bement W.M. … Mooseker M.S. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3
  4. Identification, characterization and cloning of myr 1, a mammalian myosin-I. (PMID: 8449985) Ruppert C. … BAohler M. (J. Cell Biol. 1993) 2 3
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3

Products for MYO1B Gene

Sources for MYO1B Gene

Back to Top

Content