MYO1B Gene

Aliases
for MYO1B gene

Previous GC identifers: GC02P190429 GC02P190830 GC02P192312 GC02P191935 GC02P191818 GC02P183969

Summaries
for MYO1B gene

Genomic Views
for MYO1B gene

RefSeq DNA sequence:

NC_000002.11  NC_018913.1  NT_005403.17  

SwitchGear Promoter luciferase reporter plasmid: MYO1B promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYO1B

MYO1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P192091:  view genomic region     (about GC identifiers)

Proteins
for MYO1B gene

Explore the universe of human proteins at neXtProt for MYO1B: NX_O43795

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for MYO1B
	GenScript Custom Purified and Recombinant Proteins Services for MYO1B
	Novus Biologicals MYO1B Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MYO1B

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): MYO1B OriGene Custom Antibody Services for MYO1B
	GenScript Custom Superior Antibodies Services for MYO1B
	Novus Biologicals MYO1B Antibodies
	Search for Antibodies for MYO1B at Abcam
	Uscn Antibodies for MYO1B
	ThermoFisher Antibodies for MYO1B

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MYO1B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MYO1B

Protein Domains /
Families
for MYO1B gene

ProtoNet protein and cluster: O43795

Function
for MYO1B gene

miRNA Products:		OriGene 3'-UTR Clone (see all 3): MYO1B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYO1B
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate MYO1B (see all 22):
		hsa-miR-137 hsa-miR-4328 hsa-miR-520d-5p hsa-miR-25 hsa-miR-340 hsa-miR-29b-1* hsa-miR-570 hsa-miR-223
		SwitchGear 3'UTR luciferase reporter plasmid: MYO1B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYO1B (see all 7) OriGene siRNA: MYO1B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYO1B

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for MYO1B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYO1B (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYO1B (see all 4) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): MYO1B (NM_012223)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYO1B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYO1B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MYO1B
		Search LifeMap BioReagents cell lines for MYO1B

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO1B

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

Pathways & Interactions
for MYO1B gene

	Super-pathway	contained gene-specific pathways
1	Clathrin-dependent protein traffic	Clathrin-dependent protein traffic 1.00 wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF) 0.35 Transport_Clathrin-coated vesicle cycle 0.66
2	PAK Pathway	PAK Pathway 1.00 Epithelial Adherens Junctions 0.36 Antioxidant Action of Vitamin-C 0.56
3	Fc-GammaR-Mediated Phagocytosis in Macrophages	Fc-GammaR-Mediated Phagocytosis in Macrophages 1.00 RhoGDI Pathway 0.33
4	Actin Nucleation by ARP-WASP Complex	Actin Nucleation by ARP-WASP Complex 1.00 RhoA Pathway 0.35
5	Sweet Taste Signaling	Cellular Effects of Sildenafil 0.46

1 EMD Millipore Pathway for MYO1B

Clathrin-dependent protein traffic

5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYO1B

	RhoA Pathway
	Antioxidant Action of Vitamin-C
	Transendothelial Migration of Leukocytes
	Actin Nucleation by ARP-WASP Complex
	Epithelial Adherens Junctions

2 GeneGo (Thomson Reuters) Pathways for MYO1B

	wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
	Transport Clathrin-coated vesicle cycle

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for MYO1B gene

Transcripts
for MYO1B gene

Expression
for MYO1B gene

MYO1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATCAAAATT

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	KidneyS-shaped BodyKidney Endothelial Cells			Endothelium
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	PureStem™ progenitor T36 (Embryonic Progenitor Cell)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYO1B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MYO1B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYO1B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYO1B

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO1B

Orthologs
for MYO1B gene

Paralogs
for MYO1B gene

Paralogs for MYO1B gene

MYO1D²  MYO1A²  MYO1C²  MYO1F²  MYO1G²  MYO1E²  MYO1H²  MYO19²  

18/35 SIMAP similar genes for MYO1B using alignment to 10 protein entries:     MYO1B_HUMAN (see all proteins) (see all similar genes):

MYO1A    MYO1D    MYO9A    MYO5C    MYO1C    MYO1G

MYO1E    MYO3B    DKFZp686A01173    MYO3A    MYO1H    MYO19

FLJ00395    MYO1F variant protein    MYO10    MYH9    MYO15A    MYO7A

MYO1B for paralogs           About GeneDecksing

Genomic Variants
for MYO1B gene

10/3034 NCBI SNPs in MYO1B are shown (see all 3034)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs739815171,2	C,	--	192108123(+)	AGTCTA/GACACA	2	--	us2k1		2		WA	120
rs1466464051,2		--	192108220(+)	GGTAGC/TGTGCT	2	--	us2k1		0	--	--	--	--
rs1864555701,2		--	192108221(+)	GTAGTA/GTGCTT	2	--	us2k1		0	--	--	--	--
rs1909433401,2		--	192108224(+)	GTGTGC/TTTGAT	2	--	us2k1		0	--	--	--	--
rs1163306611,2		--	192108322(+)	GATGAC/TAATCT	3	--	us2k1		1		NA	120
rs1821980621,2		--	192108440(+)	AGCTCA/GCCAAC	3	--	us2k1		0	--	--	--	--
rs1400140771,2		--	192108451(+)	TCACAC/TGCTTG	3	--	us2k1		0	--	--	--	--
rs621796321,2	C,	--	192108553(+)	CACAAT/CANNNN	3	--	us2k1		2		NA	122
rs350927181,2	C,F,	--	192108608(+)	AACTTC/TATCTC	3	--	us2k1		6		NA WA EA	364
rs1849037071,2		--	192108985(+)	AGGTCC/TCACCT	3	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for MYO1B (192109911 - 192290115 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for MYO1B: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYO1B

DNA2.0 Custom Variant and Variant Library Synthesis for MYO1B

Disorders / Diseases
for MYO1B gene

Publications
for MYO1B gene

PubMed articles for MYO1B gene, integrated from 9 sources (see all 55): (articles sorted by number of sources associating them with MYO1B)

Utopia: connect your pdf to the dynamic world of online information

1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
2. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. (PubMed id 8022818)^{1, 3} Bement W.M....Mooseker M.S. (1994)
3. Identification, characterization and cloning of myr 1, a mammalian myosin-I. (PubMed id 8449985)^{1, 3} Ruppert C....Bahler M. (1993)
4. Myosin Ib modulates the morphology and the protein transport within multi-vesicular sorting endosomes. (PubMed id 16219689)^{1, 9} Salas-Cortes L....Coudrier E. (2005)
5. Sp1 phosphorylation by cyclin-dependent kinase 1/cycli n B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)¹ Chuang J.Y....Hung J.J. (2012)
6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
7. Biochemical and phosphoproteomic analysis of the helix -loop-helix protein E47. (PubMed id 22354994)¹ Teachenor R....Murre C. (2012)
8. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)¹ Tsai Y.C....Cristea I.M. (2012)
9. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)

External Searches for MYO1B gene

Genome Databases showing MYO1B gene

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Specialized Databases showing MYO1B gene

Products
for MYO1B gene