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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MYO1A Gene

protein-coding GIFtS: 59
GCID: GC12M057422

myosin IA

(Previous symbols: MYHL, DFNA48)

Explore 10 diseases affiliated with
MYO1A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Myosin IA¹ ²		BBMI² ³
MYHL¹ ² ³		MIHC² ³
DFNA48¹ ² ⁵		Myosin, Heavy Polypeptide-Like (100kD)²
Brush Border Myosin I² ³		Unconventional Myosin-Ia²
Myosin I Heavy Chain² ³		BBM-I³

External Ids:	HGNC: 7595¹	Entrez Gene: 4640²	Ensembl: ENSG00000166866⁷	OMIM: 601478⁵	UniProtKB: Q9UBC5³

Export aliases for MYO1A gene to outside databases

Previous GC identifers: GC12M057397 GC12M057646 GC12M057139 GC12M055709 GC12M055710 GC12M055711 GC12M054460

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYO1A:

This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be

confused with the conventional skeletal muscle myosin-1 (MYH1). Unconventional myosins contain the basic domains

characteristic of conventional myosins and are further distinguished from class members by their tail domains. They

function as actin-based molecular motors. Mutations in this gene have been associated with autosomal dominant

deafness. Alternatively spliced variants have been found for this gene. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: MYO1A_HUMAN, Q9UBC5

Function: Involved in directing the movement of organelles along actin filaments (Potential)

Gene Wiki entry for MYO1A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MYO1A gene promoter:
COUP-TF COMP1 NRSF form 1 COUP Pax-2 Pax-2a NRSF form 2 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MYO1A promoter sequence

Search SABiosciences Chromatin IP Primers for MYO1A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYO1A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13-q14 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13-q15

MYO1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYO1A gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M057422: view genomic region (about GC identifiers)

Start:	57,422,301 bp from pter	End:	57,444,982 bp from pter
Size:	22,682 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MYO1A_HUMAN, Q9UBC5 (See protein sequence)

Recommended Name: Unconventional myosin-Ia

Size: 1043 amino acids; 118401 Da

Caution: Represents a unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1)

Secondary accessions: Q9UQD7

Explore the universe of human proteins at neXtProt for MYO1A: NX_Q9UBC5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UBC5

MYO1A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001242970.1 NP_005370.1

ENSEMBL proteins:

ENSP00000300119 ENSP00000393392 ENSP00000451033 ENSP00000452229 ENSP00000400991

ENSP00000440514

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	Uscn Proteins for MYO1A

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	9858156
GO:0005902	microvillus	IDA	9858156
GO:0005903	brush border	IDA	9858156
GO:0009925	basal plasma membrane	IEA	--
GO:0016323	basolateral plasma membrane	IDA	9858156

MYO1A for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for MYO1A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MYO1A for domains About GeneDecksing

3 InterPro domains/families:

IPR010926 Myosin_tail_2

IPR000048 IQ_motif_EF-hand-BS

IPR001609 Myosin_head_motor_dom

Graphical View of Domain Structure for InterPro Entry Q9UBC5

ProtoNet protein and cluster: Q9UBC5

2 Blocks protein families:

IPB000048 IQ calmodulin-binding region

IPB010926 Myosin tail 2

UniProtKB/Swiss-Prot: MYO1A_HUMAN, Q9UBC5

Similarity: Contains 3 IQ domains

Similarity: Contains 1 myosin head-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MYO1A_HUMAN, Q9UBC5

Function: Involved in directing the movement of organelles along actin filaments (Potential)

Genatlas biochemistry entry for MYO1A:

myosin IA,unconventional,apparently non filamentous,homologous to bovine Myo1a

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO1A

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003774	motor activity	IEA	--
GO:0003779	actin binding	IEA	--
GO:0005516	calmodulin binding	IEA	--
GO:0005524	ATP binding	IEA	--

MYO1A for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Myo1a^tm1Mtys for MYO1A
     2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Myo1a):

digestive/alimentary

hearing/vestibular/ear

MYO1A for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PAK Pathway

	PAK Pathway	1.00			Epithelial Adherens Junctions	0.36
	Antioxidant Action of Vitamin-C	0.56

Fc-GammaR-Mediated Phagocytosis in Macrophages

Fc-GammaR-Mediated Phagocytosis in Macrophages

1.00

RhoGDI Pathway

0.33

Actin Nucleation by ARP-WASP Complex

Actin Nucleation by ARP-WASP Complex

1.00

RhoA Pathway

0.35

Sweet Taste Signaling

Cellular Effects of Sildenafil

0.46

Rho Family GTPases

ILK Signaling

0.45

5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYO1A (see all 11)

	RhoA Pathway
	Antioxidant Action of Vitamin-C
	Transendothelial Migration of Leukocytes
	Actin Nucleation by ARP-WASP Complex
	Epithelial Adherens Junctions

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MYO1A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/59 Interacting proteins for MYO1A (Q9UBC5^{2, 3} ENSP00000300119⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 59)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BAZ1B	Q9UIG0²^,³, ENSP00000342434⁴	MINT-1894306 MINT-1894492 I2D: score=1 STRING: ENSP00000342434
FBL	P22087²^,³, ENSP00000221801⁴	MINT-1894276 I2D: score=1 STRING: ENSP00000221801
MAP3K3	Q99759²^,³	MINT-48518 I2D: score=2
SMARCA5	O60264²^,³, ENSP00000283131⁴	MINT-1894458 MINT-1894414 MINT-1894430 I2D: score=1 STRING: ENSP00000283131
USP20	Q9Y2K6³, ENSP00000313811⁴	I2D: score=2 STRING: ENSP00000313811

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007605	sensory perception of sound	IMP	12736868
GO:0030030	cell projection organization	--	--
GO:0030033	microvillus assembly	IEA	--
GO:0051648	vesicle localization	IMP	8692943

MYO1A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MYO1A for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MYO1A
10/11 Novoseek chemical compound relationships for MYO1A gene (see all 11) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphatidylserine	42.7	8	7728866 (5), 7801806 (1), 9047367 (1)
mgatp	36.1	1	1885650 (1)
phospholipid	24.8	8	7728866 (4), 2143194 (1)
atp	23.9	3	1530945 (1), 9405612 (1)
citrate	23.7	2	19465554 (1), 10751188 (1)
adp	23.4	2	7501027 (1), 9405612 (1)
phosphatidylcholine	18.9	1	9047367 (1)
calcium	9.14	4	1985037 (2), 9217259 (1), 1885650 (1)
oxygen	0	1	10751188 (1)
lipid	0	4	7728866 (1), 9047367 (1)

Search CenterWatch for drugs/clinical trials and news about MYO1A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MYO1A gene (2 alternative transcripts):

NM_001256041.1 NM_005379.3

Unigene Cluster for MYO1A:

Myosin IA

Hs.5394 [show with all ESTs]

Unigene Representative Sequence: NM_001256041

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000300119(uc001smw.4 uc009zpd.3) ENST00000442789 ENST00000554234

ENST00000477864 ENST00000487083 ENST00000476795 ENST00000492945 ENST00000433964

ENST00000471791 ENST00000544473(uc010sqz.2)

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		hsa-miR-877* hsa-miR-4307 hsa-miR-765
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		GenScript: all cDNA clones in your preferred vector: MYO1A (NM_005379)
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Additional cDNA sequence:

AF009961.1 AF105424.1 AF127026.1 AK300381.1 AK312431.1 BC059387.1 L29137.1

3 DOTS entries:

DT.70101159 DT.97838580 DT.95124178

24/81 AceView cDNA sequences (see all 81):

AF537121 CD620409 AY358679 AF537120 AF186112 BX114126 CD620413 CR620932

NM_013251 AF537115 NM_005379 BX118017 AF537113 AF537118 BC032145 AF537116

BC059387 BX479591 AF537117 AI832211 AF127026 AI139283 BG002828 AF537119

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MYO1A (see all 7) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17a	·	17b	^	18	^	19	^
SP1:																	-																												-
SP2:					-		-		-								-
SP3:									-				-		-		-		-		-		-		-		-		-		-		-
SP4:									-								-
SP5:					-		-		-

ExUns:	20	^	21	^	22	^	23	^	24	^	25a	·	25b	^	26	^	27	^	28a	·	28b	^	29	^	30
SP1:																					-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for MYO1A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MYO1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTTGGGGAT

About this image

MYO1A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Cardiomyocyte-like cells (Spontaneous differen...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MYO1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MYO1A

SOURCE GeneReport for Unigene cluster: Hs.5394

SABiosciences Custom PCR Arrays for MYO1A

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO1A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MYO1A gene from 4/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MYO1A¹	myosin IA	67.15(n) 64.44(a)		396072 NM_205163.1 NP_990494.1
lizard (Anolis carolinensis)	Reptilia	MYO1A⁶	--	58(a)	1 ↔ 1	2(70452297-70547656)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.4023²	Transcribed sequence with weak similarity to protein more	75.75(n)		AL851677.2
fruit fly (Drosophila melanogaster)	Insecta	Myo61F³	actin binding	45(a) (best of 3)		61F6 --

ENSEMBL Gene Tree for MYO1A (if available)
TreeFam Gene Tree for MYO1A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MYO1A gene

MYO1F² MYO1G² MYO1E² MYO1B² MYO1D² MYO1H² MYO1C² MYO19²

18/34 SIMAP similar genes for MYO1A using alignment to 5 protein entries: MYO1A_HUMAN (see all proteins) (see all similar genes):

MYO1B MYO9A MYO1C MYO5C MYO19 MYO3B

MYO1D MYO1H MYO1E FLJ00395 MYO1F MYO1F variant protein

DKFZp686A01173 MYO15A MYO6 MYO7A MYO5A MYO7B

MYO1A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs33962952^1,2	C,F,	pathogenic	54469947(+)	`GCTCCC/TCCAGG`	4	E G	mis¹		6		NA EU	6065
rs61753849^1,2	C,F	pathogenic	54473770(+)	`AATATC/ATCAAA`	4	/E /D	mis¹		2		NA EU	5873
rs55679042^1,2	C,F,	pathogenic	54475664(+)	`GCCCAC/TCATCT`	4	M V	mis¹		2		NA EU	5873
rs121909305^1,2	C,F,	pathogenic	54480004(-)	`GGGACC/TGAGAC`	4	R *	stg¹		2		NA EU	5871
rs57432005^1,2	C,	--	54460657(+)	`CCACCG/ACAGTC`	2	--	ds500¹		2		WA	120
rs55644218^1,2	C,	--	54461382(+)	`CTTCGC/TTTTCT`	2	--	int¹		0	--	--	--	--
rs56156199^1,2	C,F,	--	54462259(+)	`CACCCC/GCAGAG`	2	--	int¹		4		NA WA	242
rs73334782^1,2	C,	--	54462330(+)	`CAGAGC/AACAGT`	2	--	int¹		1		WA	2
rs112694227^1,2	F	--	54462661(+)	`GGAGGG/AACAGG`	2	--	int¹		1		CSA	4
rs55981065^1,2	C,F,	--	54462798(+)	`GGCTGG/AAGGAC`	2	--	int¹		1		NA	120

HapMap Linkage Disequilibrium report for MYO1A (57422301 - 57444982 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MYO1A
1 CNV: 35093
Human Gene Mutation Database (HGMD): MYO1A

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MYO1A for disorders           About GeneDecksing

OMIM gene information: 601478
OMIM disorders: 607841
UniProtKB/Swiss-Prot: MYO1A_HUMAN, Q9UBC5

Defects in MYO1A are the cause of deafness autosomal dominant type 48 (DFNA48) [MIM:607841]. DFNA48 is a form

of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear,

the nerve pathways to the brain, or the area of the brain that receives sound information

10 diseases for MYO1A: About MalaCards

deafness, autosomal dominant 48 spinal cord injury brachial plexus injuries sensorineural hearing loss

hearing loss chronic obstructive pulmonary disease myotonic dystrophy pulmonary disease

t cell deficiency retinitis

2 Novoseek disease relationships for MYO1A gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
atrophy	39.2	1	9609737 (1)
heart failure	3.2	1	9054750 (1)

Human Genome Epidemiology (HuGE) Navigator: MYO1A (1 document)

Export disorders for MYO1A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MYO1A gene, integrated from 9 sources (see all 101):
(articles sorted by number of sources associating them with MYO1A)

Utopia: connect your pdf to the dynamic
world of online information

Multiple mutations of MYO1A, a cochlear-expressed gene, in sensorineural hearing loss. (PubMed id 12736868)^{1, 2, 3, 9} Donaudy F.... Gasparini P. (2003)
Brush border myosin I (BBMI): a basally localized transcript in human jejunal enterocytes. (PubMed id 10653589)^{1, 2, 9} Li W.... Grand R.J. (2000)
Human brush border myosin-I and myosin-Ic expression in human intestine and Caco-2BBe cells. (PubMed id 9858156)^{1, 2, 9} Skowron J.F.... Mooseker M.S. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Mapping of unconventional myosins in mouse and human. (PubMed id 8884266)^{1, 3} Hasson T.... Jenkins N.A. (1996)
MYO1A (brush border myosin I) dynamics in the brush border of LLC-PK1-CL4 cells. (PubMed id 11916846)^{1, 9} Tyska M.J. and Mooseker M.S. (2002)
Human deafness mutation E385D disrupts the mechanochemical coupling and subcellular targeting of myosin-1a. (PubMed id 17981900)^{1, 9} Yengo C.M....Tyska M.J. (2008)
Brush border myosin Ia has tumor suppressor activity i n the intestine. (PubMed id 22307608)¹ Mazzolini R....Arango D. (2012)
Myosin-1A targets to microvilli using multiple membran e binding motifs in the tail homology 1 (TH1) domain. (PubMed id 22367206)¹ Mazerik J.N. and Tyska M.J. (2012)
Identification of FBXO25-interacting proteins using an integrated proteomics approach. (PubMed id 20473970)¹ Teixeira F.R.... Gomes M.D. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4640	HGNC: 7595	AceView: MYO1AandTAC3	Ensembl:ENSG00000166866	euGenes: HUgn4640
ECgene: MYO1A	H-InvDB: MYO1A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MYO1A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MYO1A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MYO1A gene:
Search GeneIP for patents involving MYO1A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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