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Aliases for MYO19 Gene

Aliases for MYO19 Gene

  • Myosin XIX 2 3 5
  • Myosin Head Domain-Containing Protein 1 3 4
  • Myosin Head Domain Containing 1 2 3
  • MYOHD1 3 4
  • Unconventional Myosin-XIX 3

External Ids for MYO19 Gene

Previous HGNC Symbols for MYO19 Gene

  • MYOHD1

Previous GeneCards Identifiers for MYO19 Gene

  • GC17M031926
  • GC17M034851
  • GC17M030788

Summaries for MYO19 Gene

GeneCards Summary for MYO19 Gene

MYO19 (Myosin XIX) is a Protein Coding gene. GO annotations related to this gene include actin binding and motor activity.

UniProtKB/Swiss-Prot for MYO19 Gene

  • Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. MYO19 is involved in mitochondrial motility.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO19 Gene

Genomics for MYO19 Gene

Regulatory Elements for MYO19 Gene

Enhancers for MYO19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G036482 1.6 FANTOM5 Ensembl ENCODE 18.1 +60.4 60433 1.2 ATF1 CREB3L1 E2F7 SIN3A ZNF2 ZNF48 ZNF121 SLC30A9 CBX5 ZNF143 LINC02001 MYO19 ZNHIT3 ENSG00000274756 LOC105371748 GC17M036461
GH17G036589 1.7 FANTOM5 ENCODE dbSUPER 16.6 -53.1 -53087 13.7 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZNF207 ZNHIT3 MYO19 ENSG00000274756 CCL4L2 DHRS11 GC17P036616 MRM1
GH17G036543 1.4 ENCODE dbSUPER 19.4 -2.3 -2345 4.9 HDGF HNRNPUL1 PKNOX1 FOXA2 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNHIT3 MYO19 ENSG00000274756 ENSG00000270871 DHRS11 GGNBP2 GC17P036546
GH17G036532 1.1 ENCODE 19.1 +8.7 8734 3.7 PKNOX1 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A FEZF1 DMAP1 YBX1 MYO19 ENSG00000270871 ENSG00000274756 ENSG00000275839 PIGW GC17M036531
GH17G036102 1.5 FANTOM5 Ensembl ENCODE 4.9 +437.4 437431 6.2 PKNOX1 ATF1 KLF17 BMI1 SCRT2 ZNF143 RELB IKZF2 CREM EGR2 CCL4 CCL3 CCL3L1 CCL3L3 CCL5 CCL18 CCL15 PIGW SLFN12L ENSG00000277089
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYO19 on UCSC Golden Path with GeneCards custom track

Genomic Location for MYO19 Gene

Chromosome:
17
Start:
36,495,633 bp from pter
End:
36,543,435 bp from pter
Size:
47,803 bases
Orientation:
Minus strand

Genomic View for MYO19 Gene

Genes around MYO19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO19 Gene

Proteins for MYO19 Gene

  • Protein details for MYO19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96H55-MYO19_HUMAN
    Recommended name:
    Unconventional myosin-XIX
    Protein Accession:
    Q96H55
    Secondary Accessions:
    • Q59GS4
    • Q9H5X2

    Protein attributes for MYO19 Gene

    Size:
    970 amino acids
    Molecular mass:
    109135 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD92272.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MYO19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO19 Gene

Post-translational modifications for MYO19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYO19 Gene

Domains & Families for MYO19 Gene

Gene Families for MYO19 Gene

Protein Domains for MYO19 Gene

Graphical View of Domain Structure for InterPro Entry

Q96H55

UniProtKB/Swiss-Prot:

MYO19_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO19: view

Function for MYO19 Gene

Molecular function for MYO19 Gene

UniProtKB/Swiss-Prot Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. MYO19 is involved in mitochondrial motility.

Gene Ontology (GO) - Molecular Function for MYO19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IEA --
GO:0032027 myosin light chain binding IEA --
genes like me logo Genes that share ontologies with MYO19: view
genes like me logo Genes that share phenotypes with MYO19: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYO19 Gene

Localization for MYO19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO19 Gene

Cytoplasm, cytoskeleton. Mitochondrion outer membrane. Note=Probably associated with the outer membrane via its N-terminal mitochondrial targeting region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYO19 gene
Compartment Confidence
cytoskeleton 4
mitochondrion 4
cytosol 4
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MYO19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0005856 cytoskeleton IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MYO19: view

Pathways & Interactions for MYO19 Gene

SuperPathways for MYO19 Gene

No Data Available

Interacting Proteins for MYO19 Gene

Selected Interacting proteins: Q96H55-MYO19_HUMAN for MYO19 Gene via IID

Gene Ontology (GO) - Biological Process for MYO19 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MYO19 Gene

Drugs & Compounds for MYO19 Gene

No Compound Related Data Available

Transcripts for MYO19 Gene

Unigene Clusters for MYO19 Gene

Myosin XIX:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYO19 Gene

No ASD Table

Relevant External Links for MYO19 Gene

GeneLoc Exon Structure for
MYO19
ECgene alternative splicing isoforms for
MYO19

Expression for MYO19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYO19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MYO19 Gene

This gene is overexpressed in Lung (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYO19 Gene



Protein tissue co-expression partners for MYO19 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MYO19 Gene:

MYO19

SOURCE GeneReport for Unigene cluster for MYO19 Gene:

Hs.302051

mRNA Expression by UniProt/SwissProt for MYO19 Gene:

Q96H55-MYO19_HUMAN
Tissue specificity: Widely expressed in multiple tissues and cell lines.

Evidence on tissue expression from TISSUES for MYO19 Gene

  • Nervous system(4.6)
  • Lung(2)
genes like me logo Genes that share expression patterns with MYO19: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYO19 Gene

Orthologs for MYO19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYO19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO19 34
  • 99.31 (n)
dog
(Canis familiaris)
Mammalia MYO19 34
  • 87.32 (n)
cow
(Bos Taurus)
Mammalia MYO19 34
  • 84.89 (n)
rat
(Rattus norvegicus)
Mammalia Myo19 34
  • 83.52 (n)
mouse
(Mus musculus)
Mammalia Myo19 34 16
  • 83.39 (n)
chicken
(Gallus gallus)
Aves MYO19 34
  • 62.94 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia myo19 34
  • 60.54 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC562279 34
  • 58.11 (n)
Species where no ortholog for MYO19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO19 Gene

ENSEMBL:
Gene Tree for MYO19 (if available)
TreeFam:
Gene Tree for MYO19 (if available)

Paralogs for MYO19 Gene

No data available for Paralogs for MYO19 Gene

Variants for MYO19 Gene

Sequence variations from dbSNP and Humsavar for MYO19 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs587777733 Pathogenic 36,537,312(+) TAGCC(A/C)CTTTG upstream-variant-2KB, reference, missense
rs1000009368 -- 36,527,688(+) CTGCA(A/G)GCACC nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime
rs1000054240 -- 36,527,925(+) CAGGC(A/G)GAGGT intron-variant
rs1000071064 -- 36,522,385(+) CGCCT(A/G)TAATC intron-variant
rs1000075249 -- 36,516,879(+) TCTTT(C/G)GGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO19 Gene

Variant ID Type Subtype PubMed ID
dgv3154n100 CNV gain 25217958
dgv3155n100 CNV gain 25217958
dgv573e214 CNV gain 21293372
esv2763162 CNV gain 21179565
esv3640471 CNV gain 21293372
esv3640472 CNV gain 21293372
esv3640473 CNV gain 21293372
nsv457734 CNV gain 19166990
nsv469760 CNV loss 16826518
nsv469796 CNV gain+loss 16826518
nsv469853 CNV gain+loss 16826518
nsv471697 CNV gain 15918152
nsv516100 CNV gain+loss 19592680
nsv574909 CNV gain 21841781

Variation tolerance for MYO19 Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.68; 91.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYO19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYO19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO19 Gene

Disorders for MYO19 Gene

Relevant External Links for MYO19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO19

No disorders were found for MYO19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYO19 Gene

Publications for MYO19 Gene

  1. Human Myo19 is a novel myosin that associates with mitochondria. (PMID: 19932026) Quintero O.A. … Cheney R.E. (Curr. Biol. 2009) 2 3 4 64
  2. Drawing the tree of eukaryotic life based on the analysis of 2,269 manually annotated myosins from 328 species. (PMID: 17877792) Odronitz F. … Kollmar M. (Genome Biol. 2007) 2 3 64
  3. Myo19 is an outer mitochondrial membrane motor and effector of starvation-induced filopodia. (PMID: 26659663) Shneyer B.I. … Henn A. (J. Cell. Sci. 2016) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for MYO19 Gene

Sources for MYO19 Gene

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