Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MYO19 Gene

Aliases for MYO19 Gene

  • Myosin XIX 2 3
  • Myosin Head Domain-Containing Protein 1 3 4
  • Myosin Head Domain Containing 1 2 3
  • MYOHD1 3 4
  • Unconventional Myosin-XIX 3
  • Myosin-XIX 3

External Ids for MYO19 Gene

Previous Symbols for MYO19 Gene

  • MYOHD1

Summaries for MYO19 Gene

GeneCards Summary for MYO19 Gene

MYO19 (Myosin XIX) is a Protein Coding gene. GO annotations related to this gene include actin binding and motor activity.

UniProtKB/Swiss-Prot for MYO19 Gene

  • Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. MYO19 is involved in mitochondrial motility.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO19 Gene

Genomics for MYO19 Gene

Genomic Location for MYO19 Gene

Start:
36,495,633 bp from pter
End:
36,543,435 bp from pter
Size:
47,803 bases
Orientation:
Minus strand

Genomic View for MYO19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYO19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO19 Gene

Regulatory Elements for MYO19 Gene

Proteins for MYO19 Gene

  • Protein details for MYO19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96H55-MYO19_HUMAN
    Recommended name:
    Unconventional myosin-XIX
    Protein Accession:
    Q96H55
    Secondary Accessions:
    • Q59GS4
    • Q9H5X2

    Protein attributes for MYO19 Gene

    Size:
    970 amino acids
    Molecular mass:
    109135 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD92272.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MYO19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO19 Gene

Proteomics data for MYO19 Gene at MOPED

Post-translational modifications for MYO19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYO19 Gene

Domains for MYO19 Gene

Gene Families for MYO19 Gene

HGNC:
  • MYOXIX :Myosins / Myosin superfamily : Class XIX

Protein Domains for MYO19 Gene

UniProtKB/Swiss-Prot:

MYO19_HUMAN
Domain:
  • Contains 2 IQ domains.:
    • Q96H55
  • Contains 1 myosin motor domain.:
    • Q96H55
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.:
    • Q96H55
genes like me logo Genes that share domains with MYO19: view

Function for MYO19 Gene

Molecular function for MYO19 Gene

UniProtKB/Swiss-Prot Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. MYO19 is involved in mitochondrial motility.

Gene Ontology (GO) - Molecular Function for MYO19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYO19: view

Phenotypes for MYO19 Gene

genes like me logo Genes that share phenotypes with MYO19: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MYO19 Gene

Localization for MYO19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO19 Gene

Cytoplasm, cytoskeleton. Mitochondrion outer membrane. Note=Probably associated with the outer membrane via its N-terminal mitochondrial targeting region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO19 Gene COMPARTMENTS Subcellular localization image for MYO19 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
cytosol 3
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MYO19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0016459 myosin complex IEA --
genes like me logo Genes that share ontologies with MYO19: view

Pathways for MYO19 Gene

SuperPathways for MYO19 Gene

No Data Available

Interacting Proteins for MYO19 Gene

Gene Ontology (GO) - Biological Process for MYO19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with MYO19: view

No data available for Pathways by source for MYO19 Gene

Transcripts for MYO19 Gene

Unigene Clusters for MYO19 Gene

Myosin XIX:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYO19 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ·
SP1: - - - - - - - - -
SP2:
SP3:
SP4: - - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - - - - - - -
SP13:
SP14:
SP15:
SP16:
SP17: - - - - -
SP18: - - - -
SP19: - - - - - - - - - - - - - - - - -
SP20:
SP21:
SP22:
SP23: - - - - - - - - - - - - - -
SP24: - - - - - - -
SP25: - - - - -
SP26: - - - -
SP27:
SP28:
SP29: -
SP30:
SP31:
SP32:

ExUns: 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b · 17c ^ 18a · 18b ^ 19a · 19b · 19c ^ 20a · 20b · 20c ·
SP1:
SP2: - - -
SP3: - - - - -
SP4:
SP5:
SP6:
SP7: - - - - - - -
SP8: - - -
SP9: - - -
SP10: - -
SP11: -
SP12:
SP13:
SP14: - - - - - -
SP15: - -
SP16:
SP17:
SP18:
SP19: - -
SP20: - - - -
SP21: - - - - -
SP22: -
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:

ExUns: 20d · 20e ^ 21a · 21b ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b · 24c ^ 25a · 25b · 25c ^ 26a · 26b · 26c ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30a · 30b
SP1:
SP2:
SP3:
SP4:
SP5: - - - - -
SP6: - - - - -
SP7:
SP8:
SP9: -
SP10: -
SP11: - - -
SP12:
SP13: - - -
SP14:
SP15:
SP16: - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27: -
SP28: - -
SP29:
SP30:
SP31:
SP32:

Relevant External Links for MYO19 Gene

GeneLoc Exon Structure for
MYO19
ECgene alternative splicing isoforms for
MYO19

Expression for MYO19 Gene

mRNA expression in normal human tissues for MYO19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MYO19 Gene

SOURCE GeneReport for Unigene cluster for MYO19 Gene Hs.302051

mRNA Expression by UniProt/SwissProt for MYO19 Gene

Q96H55-MYO19_HUMAN
Tissue specificity: Widely expressed in multiple tissues and cell lines.
genes like me logo Genes that share expressions with MYO19: view

Orthologs for MYO19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYO19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO19 36
  • 99.31 (n)
  • 99.28 (a)
cow
(Bos Taurus)
Mammalia MYO19 36
  • 84.89 (n)
  • 82.4 (a)
dog
(Canis familiaris)
Mammalia MYO19 36
  • 87.32 (n)
  • 85.79 (a)
mouse
(Mus musculus)
Mammalia Myo19 36
  • 83.39 (n)
  • 82.41 (a)
Myo19 16
rat
(Rattus norvegicus)
Mammalia Myo19 36
  • 83.52 (n)
  • 81.79 (a)
chicken
(Gallus gallus)
Aves MYO19 36
  • 62.94 (n)
  • 61.12 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia myo19 36
  • 60.54 (n)
  • 59.83 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC562279 36
  • 58.11 (n)
  • 52.82 (a)
Species with no ortholog for MYO19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO19 Gene

ENSEMBL:
Gene Tree for MYO19 (if available)
TreeFam:
Gene Tree for MYO19 (if available)

Paralogs for MYO19 Gene

genes like me logo Genes that share paralogs with MYO19: view

No data available for Paralogs for MYO19 Gene

Variants for MYO19 Gene

Sequence variations from dbSNP and Humsavar for MYO19 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs8882 -- 36,513,312(-) GGCCC(C/T)TCTGG intron-variant
rs752493 -- 36,515,970(+) TTCAT(C/T)AGGCA reference, synonymous-codon, missense
rs1109442 -- 36,506,381(+) GATCC(C/T)GGCAG intron-variant
rs1351741 -- 36,532,903(-) CCAAC(C/G)CAAAC intron-variant
rs1483544 -- 36,517,188(+) tactc(C/T)ttcat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO19 Gene

Variant ID Type Subtype PubMed ID
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850
dgv948e1 CNV Complex 17122850
dgv122e55 CNV Gain 17911159
esv2751645 CNV Gain 17911159
nsv526727 CNV Gain 19592680
nsv469796 CNV Gain 16826518
nsv471697 CNV Gain 15918152
essv6619 CNV CNV 17122850
nsv469853 CNV Complex 16826518
nsv457734 CNV Gain 19166990
nsv516100 CNV Gain+Loss 19592680
nsv469760 CNV Loss 16826518

Relevant External Links for MYO19 Gene

HapMap Linkage Disequilibrium report
MYO19

Disorders for MYO19 Gene

No disorders were found for MYO19 Gene.

No data available for UniProtKB/Swiss-Prot for MYO19 Gene

Publications for MYO19 Gene

  1. Human Myo19 is a novel myosin that associates with mitochondria. (PMID: 19932026) Quintero O.A. … Cheney R.E. (Curr. Biol. 2009) 2 3 4
  2. Drawing the tree of eukaryotic life based on the analysis of 2,269 manually annotated myosins from 328 species. (PMID: 17877792) Odronitz F. … Kollmar M. (Genome Biol. 2007) 2 3
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MYO19 Gene

Sources for MYO19 Gene

Back to Top

Content