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Aliases for MYO19 Gene

Aliases for MYO19 Gene

  • Myosin XIX 2 3 5
  • Myosin Head Domain-Containing Protein 1 3 4
  • Myosin Head Domain Containing 1 2 3
  • MYOHD1 3 4
  • Myosin-XIX 3

External Ids for MYO19 Gene

Previous HGNC Symbols for MYO19 Gene

  • MYOHD1

Previous GeneCards Identifiers for MYO19 Gene

  • GC17M031926
  • GC17M034851
  • GC17M030788

Summaries for MYO19 Gene

GeneCards Summary for MYO19 Gene

MYO19 (Myosin XIX) is a Protein Coding gene. GO annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYO7B.

UniProtKB/Swiss-Prot for MYO19 Gene

  • Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. MYO19 is involved in mitochondrial motility.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO19 Gene

Genomics for MYO19 Gene

Regulatory Elements for MYO19 Gene

Enhancers for MYO19 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MYO19 on UCSC Golden Path with GeneCards custom track

Genomic Location for MYO19 Gene

Chromosome:
17
Start:
36,495,633 bp from pter
End:
36,543,435 bp from pter
Size:
47,803 bases
Orientation:
Minus strand

Genomic View for MYO19 Gene

Genes around MYO19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO19 Gene

Proteins for MYO19 Gene

  • Protein details for MYO19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96H55-MYO19_HUMAN
    Recommended name:
    Unconventional myosin-XIX
    Protein Accession:
    Q96H55
    Secondary Accessions:
    • Q59GS4
    • Q9H5X2

    Protein attributes for MYO19 Gene

    Size:
    970 amino acids
    Molecular mass:
    109135 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD92272.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MYO19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO19 Gene

Proteomics data for MYO19 Gene at MOPED

Post-translational modifications for MYO19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for MYO19 Gene

Domains & Families for MYO19 Gene

Gene Families for MYO19 Gene

Protein Domains for MYO19 Gene

Graphical View of Domain Structure for InterPro Entry

Q96H55

UniProtKB/Swiss-Prot:

MYO19_HUMAN :
  • Contains 2 IQ domains.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • Contains 2 IQ domains.
  • Contains 1 myosin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO19: view

Function for MYO19 Gene

Molecular function for MYO19 Gene

UniProtKB/Swiss-Prot Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. MYO19 is involved in mitochondrial motility.

Gene Ontology (GO) - Molecular Function for MYO19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IEA --
GO:0032027 myosin light chain binding IEA --
genes like me logo Genes that share ontologies with MYO19: view
genes like me logo Genes that share phenotypes with MYO19: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYO19 Gene

Localization for MYO19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO19 Gene

Cytoplasm, cytoskeleton. Mitochondrion outer membrane. Note=Probably associated with the outer membrane via its N-terminal mitochondrial targeting region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO19 Gene COMPARTMENTS Subcellular localization image for MYO19 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
mitochondrion 4
nucleus 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for MYO19 Gene

Pathways & Interactions for MYO19 Gene

SuperPathways for MYO19 Gene

No Data Available

Interacting Proteins for MYO19 Gene

Gene Ontology (GO) - Biological Process for MYO19 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MYO19 Gene

Drugs & Compounds for MYO19 Gene

No Compound Related Data Available

Transcripts for MYO19 Gene

Unigene Clusters for MYO19 Gene

Myosin XIX:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYO19 Gene

No ASD Table

Relevant External Links for MYO19 Gene

GeneLoc Exon Structure for
MYO19
ECgene alternative splicing isoforms for
MYO19

Expression for MYO19 Gene

mRNA expression in normal human tissues for MYO19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MYO19 Gene

This gene is overexpressed in Lung (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MYO19 Gene



SOURCE GeneReport for Unigene cluster for MYO19 Gene Hs.302051

mRNA Expression by UniProt/SwissProt for MYO19 Gene

Q96H55-MYO19_HUMAN
Tissue specificity: Widely expressed in multiple tissues and cell lines.
genes like me logo Genes that share expression patterns with MYO19: view

Protein tissue co-expression partners for MYO19 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MYO19 Gene

Orthologs for MYO19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYO19 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYO19 35
  • 84.89 (n)
  • 82.4 (a)
dog
(Canis familiaris)
Mammalia MYO19 35
  • 87.32 (n)
  • 85.79 (a)
mouse
(Mus musculus)
Mammalia Myo19 35
  • 83.39 (n)
  • 82.41 (a)
Myo19 16
chimpanzee
(Pan troglodytes)
Mammalia MYO19 35
  • 99.31 (n)
  • 99.28 (a)
rat
(Rattus norvegicus)
Mammalia Myo19 35
  • 83.52 (n)
  • 81.79 (a)
chicken
(Gallus gallus)
Aves MYO19 35
  • 62.94 (n)
  • 61.12 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia myo19 35
  • 60.54 (n)
  • 59.83 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC562279 35
  • 58.11 (n)
  • 52.82 (a)
Species with no ortholog for MYO19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO19 Gene

ENSEMBL:
Gene Tree for MYO19 (if available)
TreeFam:
Gene Tree for MYO19 (if available)

Paralogs for MYO19 Gene

Paralogs for MYO19 Gene

genes like me logo Genes that share paralogs with MYO19: view

Variants for MYO19 Gene

Sequence variations from dbSNP and Humsavar for MYO19 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2306595 - 36,515,878(+) CAGGG(C/T)TGGAG upstream-variant-2KB, reference, synonymous-codon, missense
rs9890918 - 36,515,121(+) TTCAG(C/G)TGGAG intron-variant, upstream-variant-2KB, reference, missense
rs7217346 - 36,507,443(+) AATGA(G/T)ATCCA intron-variant, reference, missense
rs8882 -- 36,513,312(-) GGCCC(C/T)TCTGG intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs752493 -- 36,515,970(+) TTCAT(C/T)AGGCA upstream-variant-2KB, reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for MYO19 Gene

Variant ID Type Subtype PubMed ID
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850
dgv948e1 CNV Complex 17122850
dgv122e55 CNV Gain 17911159
esv2751645 CNV Gain 17911159
nsv526727 CNV Gain 19592680
nsv469796 CNV Gain 16826518
nsv471697 CNV Gain 15918152
essv6619 CNV CNV 17122850
nsv469853 CNV Complex 16826518
nsv457734 CNV Gain 19166990
nsv516100 CNV Gain+Loss 19592680
nsv469760 CNV Loss 16826518

Variation tolerance for MYO19 Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.68; 91.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYO19 Gene

HapMap Linkage Disequilibrium report
MYO19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO19 Gene

Disorders for MYO19 Gene

Relevant External Links for MYO19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO19

No disorders were found for MYO19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYO19 Gene

Publications for MYO19 Gene

  1. Human Myo19 is a novel myosin that associates with mitochondria. (PMID: 19932026) Quintero O.A. … Cheney R.E. (Curr. Biol. 2009) 2 3 4 67
  2. Drawing the tree of eukaryotic life based on the analysis of 2,269 manually annotated myosins from 328 species. (PMID: 17877792) Odronitz F. … Kollmar M. (Genome Biol. 2007) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Myo19 ensures symmetric partitioning of mitochondria and coupling of mitochondrial segregation to cell division. (PMID: 25447992) Rohn J.L. … Baum B. (Curr. Biol. 2014) 3

Products for MYO19 Gene

Sources for MYO19 Gene

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