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Aliases for MYO18B Gene

Aliases for MYO18B Gene

  • Myosin XVIIIB 2 3
  • Unconventional Myosin-XVIIIb 3
  • Myosin-XVIIIb 3
  • Myosin 18B 3

External Ids for MYO18B Gene

Previous GeneCards Identifiers for MYO18B Gene

  • GC22P022834
  • GC22P024462
  • GC22P026138
  • GC22P009085

Summaries for MYO18B Gene

Entrez Gene Summary for MYO18B Gene

  • The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYO18B Gene

MYO18B (Myosin XVIIIB) is a Protein Coding gene. Diseases associated with MYO18B include lung cancer. Among its related pathways are RhoGDI Pathway and ERK Signaling. GO annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYO18A.

UniProtKB/Swiss-Prot for MYO18B Gene

  • May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth

Gene Wiki entry for MYO18B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO18B Gene

Genomics for MYO18B Gene

Regulatory Elements for MYO18B Gene

Genomic Location for MYO18B Gene

Start:
25,742,144 bp from pter
End:
26,057,379 bp from pter
Size:
315,236 bases
Orientation:
Plus strand

Genomic View for MYO18B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYO18B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO18B Gene

Proteins for MYO18B Gene

  • Protein details for MYO18B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUG5-MY18B_HUMAN
    Recommended name:
    Unconventional myosin-XVIIIb
    Protein Accession:
    Q8IUG5
    Secondary Accessions:
    • B2RWP3
    • F5GYU7
    • Q8NDI8
    • Q8TE65
    • Q8WWS0
    • Q96KH2
    • Q96KR8
    • Q96KR9

    Protein attributes for MYO18B Gene

    Size:
    2567 amino acids
    Molecular mass:
    285185 Da
    Quaternary structure:
    • Homodimer. May interact with F actin through the GPA motif (Gly/Pro/Ala-rich)
    Miscellaneous:
    • Frequently deleted, mutated, and hypermethylated in lung cancers

    Alternative splice isoforms for MYO18B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO18B Gene

Proteomics data for MYO18B Gene at MOPED

Post-translational modifications for MYO18B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYO18B Gene

No data available for DME Specific Peptides for MYO18B Gene

Domains for MYO18B Gene

Gene Families for MYO18B Gene

HGNC:
  • MYOXVIII :Myosins / Myosin superfamily : Class XVIII

Protein Domains for MYO18B Gene

Suggested Antigen Peptide Sequences for MYO18B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUG5

UniProtKB/Swiss-Prot:

MY18B_HUMAN :
  • Q8IUG5
Domain:
  • Contains 1 IQ domain.
  • Contains 1 myosin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO18B: view

Function for MYO18B Gene

Molecular function for MYO18B Gene

UniProtKB/Swiss-Prot Function: May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth

Gene Ontology (GO) - Molecular Function for MYO18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYO18B: view

Phenotypes for MYO18B Gene

genes like me logo Genes that share phenotypes with MYO18B: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MYO18B Gene

Localization for MYO18B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO18B Gene

Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere. Note=Punctate pattern in undifferentiated myoblasts. Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO18B Gene COMPARTMENTS Subcellular localization image for MYO18B gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MYO18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm --
GO:0005813 centrosome IDA --
GO:0016459 myosin complex --
genes like me logo Genes that share ontologies with MYO18B: view

Pathways for MYO18B Gene

genes like me logo Genes that share pathways with MYO18B: view

Pathways by source for MYO18B Gene

Gene Ontology (GO) - Biological Process for MYO18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis --
GO:0001701 in utero embryonic development --
GO:0006412 translation --
GO:0008152 metabolic process IEA --
GO:0048739 cardiac muscle fiber development --
genes like me logo Genes that share ontologies with MYO18B: view

Compounds for MYO18B Gene

(1) Novoseek inferred chemical compound relationships for MYO18B Gene

Compound -log(P) Hits PubMed IDs
5-aza-2deoxycytidine 72.3 3
genes like me logo Genes that share compounds with MYO18B: view

Transcripts for MYO18B Gene

Unigene Clusters for MYO18B Gene

Myosin XVIIIB:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYO18B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b · 32c ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42 ^ 43 ^ 44a · 44b ^ 45a ·
SP1: - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - -
SP6: -
SP7:

Relevant External Links for MYO18B Gene

GeneLoc Exon Structure for
MYO18B
ECgene alternative splicing isoforms for
MYO18B

Expression for MYO18B Gene

mRNA expression in normal human tissues for MYO18B Gene

mRNA differential expression in normal tissues according to GTEx for MYO18B Gene

This gene is overexpressed in Muscle - Skeletal (29.9), Heart - Left Ventricle (11.5), and Heart - Atrial Appendage (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYO18B Gene

SOURCE GeneReport for Unigene cluster for MYO18B Gene Hs.417959

mRNA Expression by UniProt/SwissProt for MYO18B Gene

Q8IUG5-MY18B_HUMAN
Tissue specificity: Selectively expressed in cardiac and skeletal muscles. Weakly expressed in testis, pancreas, placenta, prostate, lung and thymus
genes like me logo Genes that share expressions with MYO18B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MYO18B Gene

Orthologs for MYO18B Gene

This gene was present in the common ancestor of animals.

Orthologs for MYO18B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO18B 35
  • 94.71 (n)
  • 92.91 (a)
cow
(Bos Taurus)
Mammalia MYO18B 35
  • 83.29 (n)
  • 80.41 (a)
MYO18B 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYO18B 35
  • 84.68 (n)
  • 82.65 (a)
MYO18B 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo18b 35
  • 77.72 (n)
  • 74.9 (a)
Myo18b 16
Myo18b 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYO18B 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Myo18b 35
  • 78.04 (n)
  • 74.51 (a)
chicken
(Gallus gallus)
Aves MYO18B 35
  • 64.54 (n)
  • 58.26 (a)
MYO18B 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYO18B 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myo18b 35
  • 60.77 (n)
  • 58.59 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01073112.1 36
  • 48 (a)
OneToMany
CABZ01087088.1 36
  • 35 (a)
OneToMany
MYO18B (1 of 4) 36
  • 18 (a)
OneToMany
MYO18B (3 of 4) 36
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mhcl 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
ManyToMany
Species with no ortholog for MYO18B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO18B Gene

ENSEMBL:
Gene Tree for MYO18B (if available)
TreeFam:
Gene Tree for MYO18B (if available)

Paralogs for MYO18B Gene

Paralogs for MYO18B Gene

Selected SIMAP similar genes for MYO18B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MYO18B: view

Variants for MYO18B Gene

Sequence variations from dbSNP and Humsavar for MYO18B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs132494 -- 26,007,275(+) CTGGA(C/G)CAGAA intron-variant
rs133849 -- 25,740,693(+) CCACC(C/T)GCCTT upstream-variant-2KB
rs133850 -- 25,741,237(+) TTTTT(-/TT)GAGAT upstream-variant-2KB
rs133851 -- 25,741,360(+) cgccc(C/G)gctaa upstream-variant-2KB
rs133852 -- 25,743,779(+) GAACT(C/T)AGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO18B Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2751952 CNV Gain 17911159
dgv1396e1 CNV Complex 17122850
esv2724089 CNV Deletion 23290073
esv275572 CNV Gain+Loss 21479260
esv2593623 CNV Insertion 19546169
nsv513586 CNV Insertion 21212237
nsv914953 CNV Gain 21882294

Relevant External Links for MYO18B Gene

HapMap Linkage Disequilibrium report
MYO18B
Human Gene Mutation Database (HGMD)
MYO18B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO18B Gene

Disorders for MYO18B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MYO18B Gene including...

Search for MYO18B Gene in MalaCards »

(2) Novoseek inferred disease relationships for MYO18B Gene

Disease -log(P) Hits PubMed IDs
cancer lung 49.7 12
tumors 0 3

Relevant External Links for MYO18B

Genetic Association Database (GAD)
MYO18B
Human Genome Epidemiology (HuGE) Navigator
MYO18B
genes like me logo Genes that share disorders with MYO18B: view

No data available for UniProtKB/Swiss-Prot for MYO18B Gene

Publications for MYO18B Gene

  1. MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer. (PMID: 12209013) Nishioka M. … Yokota J. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 23
  2. Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation. (PMID: 12547197) Salamon M. … Lanfranchi G. (J. Mol. Biol. 2003) 2 3 4 23
  3. Genetic alterations responsible for metastatic phenotypes of lung cancer cells. (PMID: 12741677) Yokota J. … Kohno T. (Clin. Exp. Metastasis 2003) 3 4 23
  4. Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer. (PMID: 15305387) Yanaihara N. … Yokota J. (Int. J. Cancer 2004) 3 23
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4

Products for MYO18B Gene

  • antibodies-online peptides for MYO18B
  • antibodies-online antibodies for MYO18B
  • antibodies-online kits for MYO18B

Sources for MYO18B Gene

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