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MYO18B Gene

protein-coding   GIFtS: 52
GCID: GC22P026138

Myosin XVIIIB

  See MYO18B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin XVIIIB1 2
Myosin 18B2
myosin-XVIIIb2
Unconventional Myosin-XVIIIb2

External Ids:    HGNC: 181501   Entrez Gene: 847002   Ensembl: ENSG000001334547   OMIM: 6072955   UniProtKB: Q8IUG53   

Export aliases for MYO18B gene to outside databases

Previous GC identifers: GC22P022834 GC22P024462 GC22P009085


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYO18B Gene:
The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence
intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact
with F actin. Mutations in this gene are associated with lung cancer. (provided by RefSeq, Jul 2008)

GeneCards Summary for MYO18B Gene:
MYO18B (myosin XVIIIB) is a protein-coding gene. Diseases associated with MYO18B include lung cancer. GO annotations related to this gene include motor activity and actin binding. An important paralog of this gene is MYO18A.

UniProtKB/Swiss-Prot: MY18B_HUMAN, Q8IUG5
Function: May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering
the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor
development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent
growth

Gene Wiki entry for MYO18B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYO18B gene promoter:
         c-Fos   AP-1   AML1a   p300   AP-4   SRY   FOXO4   SEF-1 (1)   c-Jun   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYO18B promoter sequence
   Search Chromatin IP Primers for MYO18B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYO18B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.1   Ensembl cytogenetic band:  22q12.1   HGNC cytogenetic band: 22q12.1

MYO18B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYO18B gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P026138:  view genomic region     (about GC identifiers)

Start:
26,138,111 bp from pter      End:
26,427,007 bp from pter
Size:
288,897 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MY18B_HUMAN, Q8IUG5 (See protein sequence)
Recommended Name: Unconventional myosin-XVIIIb  
Size: 2567 amino acids; 285185 Da
Subunit: Homodimer. May interact with F actin through the GPA motif (Gly/Pro/Ala-rich)
Developmental stage: Reaches an expression peak in the third day after induction and remains at similar level
during successive myotubule maturation
Miscellaneous: Frequently deleted, mutated, and hypermethylated in lung cancers
Secondary accessions: B2RWP3 F5GYU7 Q8NDI8 Q8TE65 Q8WWS0 Q96KH2 Q96KR8 Q96KR9
Alternative splicing: 2 isoforms:  Q8IUG5-1   Q8IUG5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MYO18B: NX_Q8IUG5

Explore proteomics data for MYO18B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYO18B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115997.5  
    ENSEMBL proteins: 
     ENSP00000441229   ENSP00000334563   ENSP00000386096   ENSP00000437587   ENSP00000444262  
     ENSP00000441301  

    MYO18B Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for MYO18B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MYOXVIII: Myosins / Myosin superfamily : Class XVIII

    5 InterPro protein domains:
     IPR027401 Myosin-like_IQ_dom
     IPR027417 P-loop_NTPase
     IPR000048 IQ_motif_EF-hand-BS
     IPR028561 MYO18A/B
     IPR001609 Myosin_head_motor_dom

    Graphical View of Domain Structure for InterPro Entry Q8IUG5

    ProtoNet protein and cluster: Q8IUG5

    UniProtKB/Swiss-Prot: MY18B_HUMAN, Q8IUG5
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 myosin head-like domain


    Find genes that share domains with MYO18B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MY18B_HUMAN, Q8IUG5
    Function: May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering
    the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor
    development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent
    growth

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003774motor activity IEA--
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with MYO18B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MYO18B:
     Increased cell number in G1, s 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Myo18b):
     cardiovascular system  homeostasis/metabolism  mortality/aging  muscle 

    Find genes that share phenotypes with MYO18B           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYO18B
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    hsa-miR-485-5p hsa-miR-4254 hsa-miR-149 hsa-miR-526b
    SwitchGear 3'UTR luciferase reporter plasmidMYO18B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MYO18B

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MY18B_HUMAN, Q8IUG5: Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere. Note=Punctate pattern in
    undifferentiated myoblasts. Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location
    was found in some cardiomyocytes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0016459myosin complex ----
    GO:0016461unconventional myosin complex IDA12547197
    GO:0030017sarcomere IEA--

    Find genes that share ontologies with MYO18B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYO18B About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    2Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35
    3RhoGDI Pathway
    Fc-GammaR-Mediated Phagocytosis in Macrophages0.33
    RhoGDI Pathway0.33
    4ERK Signaling
    ILK Signaling0.49
    5Sweet Taste Signaling
    Cellular Effects of Sildenafil0.46

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYO18B (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYO18B
    Interactions:

        GeneGlobe Interaction Network for MYO18B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYO18B (Q8IUG53 ENSP000003860964) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607093, ENSP000003499604I2D: score=1 STRING: ENSP00000349960
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    PSMC5P621953, ENSP000003105724I2D: score=1 STRING: ENSP00000310572
    MYO1CENSP000003528344STRING: ENSP00000352834
    MYO6ENSP000003589944STRING: ENSP00000358994
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis ----
    GO:0001701in utero embryonic development ----
    GO:0006412translation ----
    GO:0048739cardiac muscle fiber development ----

    Find genes that share ontologies with MYO18B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYO18B (MY18B)

    1 Novoseek inferred chemical compound relationship for MYO18B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 72.3 6 15751041 (1), 12209013 (1), 15305387 (1)



    Find genes that share compounds with MYO18B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYO18B gene: 
    NM_032608.5  

    Unigene Cluster for MYO18B:

    Myosin XVIIIB
    Hs.417959  [show with all ESTs]
    Unigene Representative Sequence: NM_032608
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536101(uc003aca.1) ENST00000335473(uc003abz.1 uc010guy.1 uc010guz.1 uc011aka.1 uc010gva.1 uc010gvb.1)
    ENST00000407587 ENST00000539302 ENST00000418374(uc011akb.1) ENST00000534908
    ENST00000536204 ENST00000539544 ENST00000543971 ENST00000540454
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate MYO18B:
    hsa-miR-485-5p hsa-miR-4254 hsa-miR-149 hsa-miR-526b
    SwitchGear 3'UTR luciferase reporter plasmidMYO18B 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: MYO18B (NM_032608)
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      QuantiTect SYBR Green Assays in human, mouse, rat MYO18B
      QuantiFast Probe-based Assays in human, mouse, rat MYO18B

    Additional mRNA sequence: 

    AB042648.2 AB075376.1 AJ271918.1 AJ310931.2 AK095943.1 AK123936.1 AL833890.1 AY077700.1 
    BC144596.1 BC144597.1 BC150626.1 CR749556.1 

    11 DOTS entries:

    DT.431242  DT.99932561  DT.40258444  DT.101981467  DT.100750227  DT.100018555  DT.120675171  DT.75145738 
    DT.100655097  DT.120675199  DT.91819346 

    Selected AceView cDNA sequences (see all 42):

    NM_032608 AB075376 AY077700 AL833890 AJ310931 AK095943 BM722939 BX646937 
    H55541 H55072 F36455 AB042648 BG615805 AK123936 BQ931968 CR749556 
    BF695174 AJ271918 BX502365 CD634176 F21473 BG113122 BG723415 F27546 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MYO18B (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                -                                                                                                                           
    SP2:                                -                                                                                                                           
    SP3:                                -                                                                                                                           
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b · 32c ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42 ^ 43 ^ 44a · 44b ^ 45a ·
    SP1:                                -     -                                                                                                           -         
    SP2:                                -     -                                                                                                           -         
    SP3:                                -     -                                                                                                                     
    SP4:                                -     -                                                                                                                     
    SP5:                                                                                                                                -                 -         


    ECgene alternative splicing isoforms for MYO18B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYO18B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCACCCTCA
    MYO18B Expression
    About this image

    MYO18B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYO18B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.417959

    UniProtKB/Swiss-Prot: MY18B_HUMAN, Q8IUG5
    Tissue specificity: Selectively expressed in cardiac and skeletal muscles. Weakly expressed in testis, pancreas,
    placenta, prostate, lung and thymus

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO18B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MYO18B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myo18b1 , 5 myosin XVIIIb1, 5 77.72(n)1
    74.9(a)1
      5 (54.80 cM)5
    743761  NM_028901.21  NP_083177.21 
     1126888765 
    chicken
    (Gallus gallus)
    Aves MYO18B1 myosin XVIIIB 64.54(n)
    58.26(a)
      416905  XM_415196.4  XP_415196.4 
    lizard
    (Anolis carolinensis)
    Reptilia MYO18B6
    myosin XVIIIB
    57(a)
    1 ↔ 1
    AAWZ02039729(792-6711)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX684488.12   -- 75.27(n)    BX684488.1 
    zebrafish
    (Danio rerio)
    Actinopterygii MYO18B (3 of 4)6
    CABZ01073112.16
    (see all 4)
    Uncharacterized protein
    (see all 4)
    61(a)
    48(a)
    (see all 4)
    many → 1
    many → 1
    (see all 4)
    10(45962599-45963238) ENSDARG00000090163
    10(45967086-45994332) ENSDARG00000091350
    fruit fly
    (Drosophila melanogaster)
    Insecta Mhcl6
    Myosin heavy chain-like
    25(a)
    1 → many
    3R(11894245-11924483)


    ENSEMBL Gene Tree for MYO18B (if available)
    TreeFam Gene Tree for MYO18B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYO18B gene
    MYO18A2  
    7 SIMAP similar genes for MYO18B using alignment to 5 protein entries:     MY18B_HUMAN (see all proteins):
    DKFZp779C1668    MYO18A    MYH9    MAJN    MYO1B    MYH10
    MYH11

    Find genes that share paralogs with MYO18B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYO18B (see all 7217)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57611701,2,,4
    C,F,HA lung adenocarcinoma sample4 --26173661(+) TGGGCC/TGGAGT 2 R W mis1 ese326Minor allele frequency- T:0.07NS EA NA WA CSA EU 2778
    VAR_0158664
    A lung large cell carcinoma sample4--see VAR_0158662 T M mis40--------
    VAR_0158754
    A lung small cell carcinoma sample4--see VAR_0158752 A E mis40--------
    VAR_0158724
    A lung adenocarcinoma sample4--see VAR_0158722 P T mis40--------
    VAR_0158704
    A lung small cell carcinoma sample4--see VAR_0158702 R Q mis40--------
    VAR_0158684
    A lung squamous cell carcinoma sample4--see VAR_0158682 A G mis40--------
    VAR_0158694
    A lung adenocarcinoma sample4--see VAR_0158692 R L mis40--------
    VAR_0158744
    A lung adenocarcinoma sample4--see VAR_0158742 E D mis40--------
    VAR_0158764
    A lung small cell carcinoma sample4--see VAR_0158762 G C mis40--------
    VAR_0158654
    A lung adenocarcinoma sample4--see VAR_0158652 W C mis40--------

    HapMap Linkage Disequilibrium report for MYO18B (26138111 - 26388111 bp, first 250kb of MYO18B)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MYO18B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724089CNV Deletion23290073
    esv2593623CNV Insertion19546169
    nsv513586CNV Insertion21212237
    esv2751952CNV Gain17911159
    nsv914953CNV Gain21882294
    esv275572CNV Gain+Loss21479260
    dgv1396e1CNV Complex17122850
    nsv7350OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): MYO18B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYO18B
    DNA2.0 Custom Variant and Variant Library Synthesis for MYO18B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607295    OMIM disorders: --

    1 disease for MYO18B:    
    About MalaCards
    lung cancer


    Find genes that share disorders with MYO18B           About GenesLikeMe

    2 Novoseek inferred disease relationships for MYO18B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 49.7 17 12209013 (5), 12741677 (4), 15751041 (1), 15305387 (1) (see all 5)
    tumors 0 3 12209013 (2), 17294804 (1)

    Genetic Association Database (GAD): MYO18B
    Human Genome Epidemiology (HuGE) Navigator: MYO18B (2 documents)

    Export disorders for MYO18B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYO18B gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with MYO18B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer. (PubMed id 12209013)1, 2, 3, 9 Nishioka M.... Yokota J. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation. (PubMed id 12547197)1, 2, 3, 9 Salamon M....Lanfranchi G. (J. Mol. Biol. 2003)
    3. Genetic alterations responsible for metastatic phenotypes of lung cancer cells. (PubMed id 12741677)1, 2, 9 Yokota J.... Kohno T. (Clin. Exp. Metastasis 2003)
    4. A genome-wide association study of serum uric acid in African Americans. (PubMed id 21294900)1, 4 Charles B.A....Rotimi C.N. (BMC Med Genomics 2011)
    5. Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression. (PubMed id 20713499)1, 4 Huang J....Smoller J.W. (Am J Psychiatry 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
    8. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    9. Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer. (PubMed id 15305387)1, 9 Yanaihara N....Yokota J. (Int. J. Cancer 2004)
    10. Restored expression of the MYO18B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice. (PubMed id 17294804)1, 9 Edakuni N....Sone S. (Oncol. Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 84700 HGNC: 18150 AceView: MYO18B Ensembl:ENSG00000133454 euGenes: HUgn84700
    ECgene: MYO18B H-InvDB: MYO18B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MYO18B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYO18B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MYO18B gene:
    Search GeneIP for patents involving MYO18B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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