Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYO18A Gene

protein-coding   GIFtS: 55
GCID: GC17M027400

Myosin XVIIIA

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Myosin XVIIIA1 2     Myosin 18A2
Molecule Associated With JAK3 N-Terminus2 3     Myosin Containing PDZ Domain2
Myosin Containing A PDZ Domain2 3     myosin-XVIIIa2
MAJN2 3     SP-A Receptor Subunit SP-R210 AlphaS2
MYSPDZ2 3     Unconventional Myosin-XVIIIa2
SPR2102 5     KIAA02163

External Ids:    HGNC: 311041   Entrez Gene: 3996872   Ensembl: ENSG000001965357   OMIM: 6100675   UniProtKB: Q926143   

Export aliases for MYO18A gene to outside databases

Previous GC identifers: GC17M027547 GC17M024425 GC17M023608


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MYO18A Gene: 
MYO18A (myosin XVIIIA) is a protein-coding gene. Diseases associated with MYO18A include stem cell leukemia, and vesicoureteral reflux, and among its related super-pathways are Signaling by FGFR1 mutants and Signaling by FGFR. GO annotations related to this gene include motor activity and DNA-dependent ATPase activity. An important paralog of this gene is MYO18B.

UniProtKB/Swiss-Prot: MY18A_HUMAN, Q92614
Function: May be involved in the maintenance of the stromal cell architectures required for cell to cell contact
(By similarity). In concert with LURAP1 and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin
retrograde flow that is crucial to cell protrusion and migration

Gene Wiki entry for MYO18A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010799.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYO18A gene promoter:
         Spz1   Pax-5   Sp1   SREBP-1c   MyoD   Nkx5-1   SREBP-1b   FAC1   SREBP-1a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): MYO18A promoter sequence
   Search SABiosciences Chromatin IP Primers for MYO18A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYO18A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

MYO18A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYO18A gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M027400:  view genomic region     (about GC identifiers)

Start:
27,400,528 bp from pter      End:
27,507,430 bp from pter
Size:
106,903 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MY18A_HUMAN, Q92614 (See protein sequence)
Recommended Name: Unconventional myosin-XVIIIa  
Size: 2054 amino acids; 233115 Da
Subunit: Homodimer. Interacts with JAK3 and actin. Forms a tripartite complex with CDC42BPA/CDC42BPB and LURAP1
with the latter acting as an adapter connecting CDC42BPA/CDC42BPB and MYO18A
Subcellular location: Isoform 1: Endoplasmic reticulum-Golgi intermediate compartment (By similarity). Cytoplasm,
cytoskeleton. Note=Colocalizes with actin
Subcellular location: Isoform 2: Cytoplasm. Note=Lacks the PDZ domain. Diffusely localized in the cytoplasm
Caution: The TIAF1 protein is coded in the 3'-UTR region of MYO18A
Sequence caution: Sequence=BAA13206.2; Type=Erroneous initiation; Sequence=BAD66838.1; Type=Erroneous initiation;
Secondary accessions: Q5H9U3 Q5W9F9 Q5W9G1 Q8IXP8
Alternative splicing: 5 isoforms:  Q92614-1   Q92614-2   Q92614-3   Q92614-4   Q92614-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MYO18A: NX_Q92614

Explore proteomics data for MYO18A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92614

  • MYO18A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MYO18A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_510880.2  NP_976063.1  

    ENSEMBL proteins: 
     ENSP00000435932   ENSP00000434228   ENSP00000437073   ENSP00000434817   ENSP00000465542  
     ENSP00000436660   ENSP00000346291  
    Reactome Protein details: Q92614
    Human Recombinant Protein Products for MYO18A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MYO18A
    GenScript Custom Purified and Recombinant Proteins Services for MYO18A
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYO18A 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IEA--
    GO:0005802trans-Golgi network IDA19837035
    GO:0005856cytoskeleton ----
    GO:0016459myosin complex IEA--
    GO:0042641actomyosin IDA18854160

    MYO18A for ontologies           About GeneDecksing



    MYO18A Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MYO18A
    GenScript Custom Superior Antibodies Services for MYO18A
    Novus Biologicals MYO18A Antibodies
    Abcam antibodies for MYO18A
    Cloud-Clone Corp. Antibodies for MYO18A 
    Search ThermoFisher Antibodies for MYO18A
    Search LSBio for Antibodies for MYO18A 

    Assay Products for MYO18A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MYO18A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MYO18A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MYO18A 
    Cloud-Clone Corp. CLIAs for MYO18A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MYOXVIII: Myosins / Myosin superfamily : Class XVIII

    5/7 InterPro protein domains (see all 7):
     IPR027401 Myosin-like_IQ_dom
     IPR020587 RecA_monomer-monomer_interface
     IPR027417 P-loop_NTPase
     IPR001478 PDZ
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry Q92614

    ProtoNet protein and cluster: Q92614

    2 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB003345 M protein repeat


    UniProtKB/Swiss-Prot: MY18A_HUMAN, Q92614
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 myosin head-like domain
    Similarity: Contains 1 PDZ (DHR) domain


    MYO18A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MY18A_HUMAN, Q92614
    Function: May be involved in the maintenance of the stromal cell architectures required for cell to cell contact
    (By similarity). In concert with LURAP1 and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin
    retrograde flow that is crucial to cell protrusion and migration

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003774motor activity IEA--
    GO:0005515protein binding IPI19837035
    GO:0005524ATP binding IDA--
    GO:0008094DNA-dependent ATPase activity ----
         
    MYO18A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MYO18A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MYO18A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYO18A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYO18A 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYO18A
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate MYO18A (see all 24):
    hsa-miR-125a-5p hsa-miR-331-3p hsa-miR-3154 hsa-miR-125b hsa-miR-3649 hsa-miR-3174 hsa-miR-761 hsa-miR-635
    SwitchGear 3'UTR luciferase reporter plasmidMYO18A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MYO18A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYO18A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MYO18A
    Sirion Biotech Customized adenovirus for overexpression of MYO18A

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MYO18A (see all 9)
    OriGene ORF clones in mouse, rat for MYO18A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MYO18A (NM_078471)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYO18A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYO18A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MYO18A
    Search LifeMap BioReagents cell lines for MYO18A
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO18A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MYO18A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR1 mutants
    Signaling by FGFR1 mutants0.67
    Signaling by FGFR1 fusion mutants0.63
    Signaling by FGFR mutants0.67
    2Signaling by FGFR
    Signaling by FGFR in disease0.91
    3Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5        Reactome Pathways for MYO18A
        Signaling by FGFR mutants
    Signaling by FGFR1 fusion mutants
    Signaling by FGFR in disease
    Signaling by FGFR1 mutants
    Disease



    MYO18A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYO18A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/16 Interacting proteins for MYO18A (Q926141, 3 ENSP000003462914) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOLPH3Q9H4A61, 3, ENSP000002650704EBI-949059,EBI-2465479 I2D: score=1 STRING: ENSP00000265070
    ATXN1P542533, ENSP000002447694I2D: score=2 STRING: ENSP00000244769
    MARK4Q96L343, ENSP000003008434I2D: score=2 STRING: ENSP00000300843
    CDC42BPAQ5VT253, ENSP000003557314I2D: score=1 STRING: ENSP00000355731
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006259DNA metabolic process IEA--
    GO:0007030Golgi organization IMP19837035
    GO:0016477cell migration IMP18854160
    GO:0031032actomyosin structure organization IMP18854160
    GO:0038032termination of G-protein coupled receptor signaling pathway ----

    MYO18A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MYO18A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MYO18A (MY18A)

    1 Novoseek inferred chemical compound relationship for MYO18A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 25.1 4 14969583 (2)

    Search CenterWatch for drugs/clinical trials and news about MYO18A / MY18A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYO18A gene (2 alternative transcripts): 
    NM_078471.3  NM_203318.1  

    Unigene Cluster for MYO18A:

    Myosin XVIIIA
    Hs.462590  [show with all ESTs]
    Unigene Representative Sequence: D86970
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000529578 ENST00000533112(uc010csa.1) ENST00000531253(uc010wbc.1)
    ENST00000527372(uc002hdt.1 uc002hdu.1) ENST00000530254(uc002hds.2 uc010wbd.1)
    ENST00000546105 ENST00000532867 ENST00000527312 ENST00000531438 ENST00000531892
    ENST00000529889 ENST00000530557 ENST00000533652 ENST00000532143 ENST00000533399
    ENST00000588791 ENST00000590242 ENST00000528564
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYO18A
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate MYO18A (see all 24):
    hsa-miR-125a-5p hsa-miR-331-3p hsa-miR-3154 hsa-miR-125b hsa-miR-3649 hsa-miR-3174 hsa-miR-761 hsa-miR-635
    SwitchGear 3'UTR luciferase reporter plasmidMYO18A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MYO18A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYO18A
    Clone
    Products:
         
    OriGene clones in human, mouse for MYO18A (see all 9)
    OriGene ORF clones in mouse, rat for MYO18A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MYO18A (NM_078471)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYO18A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYO18A
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MYO18A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MYO18A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYO18A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYO18A

    Additional mRNA sequence: 

    AB177858.1 AB177860.1 AF105277.1 AF252258.1 AK294180.1 AK302505.1 AK302725.1 AK303522.1 
    AY703984.1 BC039612.1 BC047669.1 BC058075.1 BC131561.1 BC131586.1 CR933614.1 D86970.2 

    24/25 DOTS entries (see all 25):

    DT.102833620  DT.100029510  DT.100818688  DT.447608  DT.100818687  DT.95225182  DT.100029511  DT.100801802 
    DT.91676723  DT.120988031  DT.86854815  DT.100818685  DT.100818691  DT.75146885  DT.120987899  DT.120987943 
    DT.120988018  DT.91846798  DT.92442605  DT.92442606  DT.92442610  DT.95225183  DT.97846576  DT.91980304 

    24/311 AceView cDNA sequences (see all 311):

    CB268076 BP345876 AW576350 AJ571771 CA448626 T32051 AL134760 BQ548890 
    BM708914 AA828079 BM694331 CB129854 AA907175 AA402957 BM048273 BP368171 
    AL046057 AK122870 BI092916 BQ650206 CA309726 BQ718431 BQ058479 BQ227330 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for MYO18A (see all 18)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c · 16d ^ 17a ·
    SP1:        -           -     -     -     -     -     -     -     -     -     -     -     -                                                                     
    SP2:                                                  -     -     -     -     -     -     -                                                                     
    SP3:                    -     -     -     -     -     -     -     -     -     -     -     -                                                                     
    SP4:                                                                                                                                                            
    SP5:                                      -     -     -     -     -     -     -     -     -                 -     -                                             

    ExUns: 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37a ·
    SP1:                                                  -                                         -                                                           -   
    SP2:                                                  -                                         -                                                           -   
    SP3:                                                  -                                         -                                                           -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 37b ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45a · 45b ^ 46 ^ 47 ^ 48a · 48b ^ 49a · 49b ^ 50a · 50b · 50c · 50d ^ 51 ^ 52 ^ 53a · 53b · 53c
    SP1:                                            -     -     -                 -                       -     -                                             
    SP2:                                            -     -     -                 -                       -     -                 -                           
    SP3:                    -                       -     -     -                 -                       -     -                 -                           
    SP4:                                                                          -                       -     -                 -                           
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for MYO18A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYO18A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MYO18A Expression
    About this image


    See MYO18A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYO18A

    SOURCE GeneReport for Unigene cluster: Hs.462590
        SABiosciences Expression via Pathway-Focused PCR Array including MYO18A: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MYO18A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MYO18A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYO18A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYO18A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO18A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MYO18A gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myo18a1 , 5 myosin XVIIIA1, 5 88.71(n)1
    94.69(a)1
      11 (46.74 cM)5
    3600131  NM_011586.21  NP_035716.11 
     777632465 
    chicken
    (Gallus gallus)
    Aves MYO18A1 myosin XVIIIA 80.75(n)
    84.9(a)
      417581  XM_415827.3  XP_415827.3 
    lizard
    (Anolis carolinensis)
    Reptilia MYO18A6
    Uncharacterized protein
    80(a)
    1 ↔ 1
    GL343462.1(126090-277251)
    zebrafish
    (Danio rerio)
    Actinopterygii myo18ab6
    myo18aa6
    myosin XVIIIAa
    75(a)
    55(a)
    1 ↔ many
    1 ↔ many
    15(23305108-23469164)
    10(38273747-38406003)
    fruit fly
    (Drosophila melanogaster)
    Insecta Mhcl1 Myosin heavy chain-like 52.13(n)
    43.06(a)
      41955  NM_001043250.2  NP_001036715.1 


    ENSEMBL Gene Tree for MYO18A (if available)
    TreeFam Gene Tree for MYO18A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYO18A gene
    MYO18B2  
    13 SIMAP similar genes for MYO18A using alignment to 6 protein entries:     MY18A_HUMAN (see all proteins):
    MAJN    MYH7    MYO18B    MYH10    MYH11    MYH14
    MYO1E    MYH9    MYO1B    MYH2    MYO10    MYO1A
    MYO5C

    MYO18A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2076 SNPs in MYO18A are shown (see all 2076)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs612925241,2
    C--23642881(+) AAAAA-/A/AA  
            
    GACAC
    2 -- int11NA 2
    rs718408151,2
    C--23652618(+) AGGAA-/GATAC 
            
    GGAGC
    2 -- int10--------
    rs1894087461,2
    --27404658(+) CCAATC/TCTCCT 2 -- int10--------
    rs732683131,2
    C,F--27404670(+) GGAGCG/AGGTGG 2 -- int12Minor allele frequency- A:0.08WA 120
    rs1418411151,2
    C--27404704(+) CAGCTC/TTCCTG 2 -- int10--------
    rs803263521,2
    C,F--27404749(+) AGAAAC/TAGGCT 2 -- int11Minor allele frequency- T:0.10WA 118
    rs1455841741,2
    --27404939(+) TCTCCA/CAGGTC 2 -- int10--------
    rs80751341,2
    C,F,A,H--27404953(+) CAGCTA/GACTTC 2 -- int121Minor allele frequency- G:0.46NS EA NA WA CSA 2344
    rs80804531,2
    C,F,A,H--27405044(+) TATATT/ATTTTT 2 -- int14Minor allele frequency- A:0.50WA NA CSA 8
    rs2012110341,2
    --27405044(+) TATAT-/ATTTTT 2 -- int10--------

    HapMap Linkage Disequilibrium report for MYO18A (27400528 - 27507430 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MYO18A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833408CNV Loss17160897
    nsv2020CNV Loss18451855
    nsv908030CNV Loss21882294
    nsv908029CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MYO18A
    DNA2.0 Custom Variant and Variant Library Synthesis for MYO18A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610067    OMIM disorders: --

    8 diseases for MYO18A:    About MalaCards
    stem cell leukemia    vesicoureteral reflux    eosinophilia    colon adenocarcinoma
    t-cell leukemia    tuberculosis    leukemia    adenocarcinoma


    MYO18A for disorders           About GeneDecksing

    Genetic Association Database (GAD): MYO18A
    Human Genome Epidemiology (HuGE) Navigator: MYO18A (1 document)

    Export disorders for MYO18A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYO18A gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with MYO18A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A). (PubMed id 12761286)1, 2, 3 Mori K.... Obinata M. (2003)
    2. The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site. (PubMed id 15835906)1, 2, 9 Isogawa Y....Sutoh K. (2005)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow. (PubMed id 18854160)1, 2 Tan I....Leung T. (2008)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. Alternative splice variants encoding unstable protein domains exist in the human brain. (PubMed id 15491607)1, 2 Homma K.... Nishikawa K. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival. (PubMed id 10733938)1, 2 Ji H.... Zheng Z. (2000)
    9. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
    10. GOLPH3L antagonizes GOLPH3 to determine Golgi morpholo gy. (PubMed id 23345592)1 Ng M.M....Field S.J. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 399687 HGNC: 31104 AceView: TIAF1 Ensembl:ENSG00000196535 euGenes: HUgn399687
    ECgene: MYO18A H-InvDB: MYO18A

    (According to HUGE)
    About This Section
    HUGE: KIAA0216

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYO18A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYO18A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYO18A gene:
    Search GeneIP for patents involving MYO18A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MYO18A  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MYO18A  
     OriGene qSTAR qPCR primer pairs in human, mouse for MYO18A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MYO18A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MYO18A   OriGene Custom Protein Services for MYO18A  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MYO18A
     QIAGEN SeqTarget long-range PCR primers for resequencing MYO18A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYO18A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYO18A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYO18A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYO18A
     GenScript Custom Purified and Recombinant Proteins Services for MYO18A GenScript cDNA clones with any tag delivered in your preferred vector for MYO18A
     GenScript Custom Assay Services for MYO18A GenScript Custom Superior Antibodies Services for MYO18A
     GenScript Custom overexpressing Cell Line Services for MYO18A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MYO18A promoter
     Search Chromatin IP Primers for MYO18A
     RT2 qPCR Primer Assay in human, mouse, rat MYO18A
     Search GNC Networks for MYO18A
     SABiosciences PCR Arrays including human, mouse, rat MYO18A
     Search Tocris compounds for MYO18A (MY18A)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MYO18A antibodies
     Antibodies for MYO18A
     See all of Abcam's Antibodies, Kits and Proteins for MYO18A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MYO18A
     Antibodies for MYO18A
     ELISAs for MYO18A
     CLIAs for MYO18A
     Search LifeMap BioReagents cell lines for MYO18A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO18A
     SwitchGear 3'UTR luciferase reporter plasmids for MYO18A
     SwitchGear Promoter luciferase reporter plasmids for MYO18A
     Search ThermoFisher Antibodies for MYO18A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYO18A
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MYO18A
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MYO18A
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression of MYO18A
     Search LSBio for Antibodies for MYO18A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MYO18A gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4