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Aliases for MYO18A Gene

Aliases for MYO18A Gene

  • Myosin XVIIIA 2 3 5
  • Molecule Associated With JAK3 N-Terminus 3 4
  • Myosin Containing A PDZ Domain 3 4
  • MYSPDZ 3 4
  • MAJN 3 4
  • SP-A Receptor Subunit SP-R210 AlphaS 3
  • Myosin Containing PDZ Domain 3
  • Myosin-XVIIIa 3
  • Myosin 18A 3
  • KIAA0216 4
  • SPR210 3

External Ids for MYO18A Gene

Previous GeneCards Identifiers for MYO18A Gene

  • GC17M027547
  • GC17M024425
  • GC17M027400
  • GC17M023608

Summaries for MYO18A Gene

GeneCards Summary for MYO18A Gene

MYO18A (Myosin XVIIIA) is a Protein Coding gene. Diseases associated with MYO18A include 8P11 Myeloproliferative Syndrome. Among its related pathways are FGFR1 mutant receptor activation and Infectious disease. GO annotations related to this gene include poly(A) RNA binding and actin filament binding. An important paralog of this gene is MYO18B.

UniProtKB/Swiss-Prot for MYO18A Gene

  • May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact.

Gene Wiki entry for MYO18A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO18A Gene

Genomics for MYO18A Gene

Regulatory Elements for MYO18A Gene

Enhancers for MYO18A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MYO18A on UCSC Golden Path with GeneCards custom track

Promoters for MYO18A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MYO18A on UCSC Golden Path with GeneCards custom track

Genomic Location for MYO18A Gene

Chromosome:
17
Start:
29,073,510 bp from pter
End:
29,180,412 bp from pter
Size:
106,903 bases
Orientation:
Minus strand

Genomic View for MYO18A Gene

Genes around MYO18A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO18A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO18A Gene

Proteins for MYO18A Gene

  • Protein details for MYO18A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92614-MY18A_HUMAN
    Recommended name:
    Unconventional myosin-XVIIIa
    Protein Accession:
    Q92614
    Secondary Accessions:
    • Q5H9U3
    • Q5W9F9
    • Q5W9G1
    • Q8IXP8

    Protein attributes for MYO18A Gene

    Size:
    2054 amino acids
    Molecular mass:
    233115 Da
    Quaternary structure:
    • Homodimer. Forms a tripartite complex with CDC42BPA/CDC42BPB and LURAP1 with the latter acting as an adapter connecting CDC42BPA/CDC42BPB and MYO18A. Binds F-actin; regulated by ADP and GOLPH3. Interacts with GOLPH3; the interaction is direct and may link Golgi membranes to the actin cytoskeleton. Interacts with JAK3.
    SequenceCaution:
    • Sequence=BAA13206.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD66838.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MYO18A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO18A Gene

Proteomics data for MYO18A Gene at MOPED

Post-translational modifications for MYO18A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYO18A Gene

No data available for DME Specific Peptides for MYO18A Gene

Domains & Families for MYO18A Gene

Gene Families for MYO18A Gene

Graphical View of Domain Structure for InterPro Entry

Q92614

UniProtKB/Swiss-Prot:

MY18A_HUMAN :
  • The myosin motor domain binds ADP and ATP but has no intrinsic ATPase activity. Mediates ADP-dependent binding to actin (PubMed:23990465).
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • The myosin motor domain binds ADP and ATP but has no intrinsic ATPase activity. Mediates ADP-dependent binding to actin (PubMed:23990465).
  • Contains 1 IQ domain.
  • Contains 1 myosin motor domain.
  • Contains 1 PDZ (DHR) domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO18A: view

Function for MYO18A Gene

Molecular function for MYO18A Gene

UniProtKB/Swiss-Prot Function:
May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact.

Gene Ontology (GO) - Molecular Function for MYO18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008094 DNA-dependent ATPase activity IEA --
GO:0051015 actin filament binding IEA,IDA 23990465
genes like me logo Genes that share ontologies with MYO18A: view
genes like me logo Genes that share phenotypes with MYO18A: view

Animal Models for MYO18A Gene

MGI Knock Outs for MYO18A:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYO18A Gene

Localization for MYO18A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO18A Gene

Isoform 1: Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasm, cytoskeleton. Note=Colocalizes with actin.
Isoform 2: Cytoplasm. Note=Lacks the PDZ domain. Diffusely localized in the cytoplasm.
Golgi apparatus. Golgi apparatus, trans-Golgi network. Note=Recruited to the Golgi apparatus by GOLPH3.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO18A Gene COMPARTMENTS Subcellular localization image for MYO18A gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MYO18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IMP 19837035
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
GO:0016459 myosin complex IEA --
genes like me logo Genes that share ontologies with MYO18A: view

Pathways & Interactions for MYO18A Gene

genes like me logo Genes that share pathways with MYO18A: view

Gene Ontology (GO) - Biological Process for MYO18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IMP 19837035
GO:0031032 actomyosin structure organization IMP 18854160
GO:0048194 Golgi vesicle budding IMP 19837035
GO:0050714 positive regulation of protein secretion IMP 23345592
genes like me logo Genes that share ontologies with MYO18A: view

No data available for SIGNOR curated interactions for MYO18A Gene

Drugs & Compounds for MYO18A Gene

(1) Drugs for MYO18A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MYO18A: view

Transcripts for MYO18A Gene

Unigene Clusters for MYO18A Gene

Myosin XVIIIA:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYO18A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c · 16d ^ 17a ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - -
SP4:
SP5: - - - - - - - - - - -
SP6: - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

ExUns: 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37a ·
SP1: - - -
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

ExUns: 37b ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45a · 45b ^ 46 ^ 47 ^ 48a · 48b ^ 49a · 49b ^ 50a · 50b · 50c · 50d ^ 51 ^ 52 ^ 53a · 53b · 53c
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - -
SP13: -
SP14: - -
SP15: - - - - -
SP16:
SP17: -
SP18:

Relevant External Links for MYO18A Gene

GeneLoc Exon Structure for
MYO18A
ECgene alternative splicing isoforms for
MYO18A

Expression for MYO18A Gene

mRNA expression in normal human tissues for MYO18A Gene

mRNA differential expression in normal tissues according to GTEx for MYO18A Gene

This gene is overexpressed in Muscle - Skeletal (x7.7).

Protein differential expression in normal tissues from HIPED for MYO18A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.8), Cervix (7.4), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYO18A Gene



SOURCE GeneReport for Unigene cluster for MYO18A Gene Hs.462590

genes like me logo Genes that share expression patterns with MYO18A: view

Protein tissue co-expression partners for MYO18A Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MYO18A Gene

Orthologs for MYO18A Gene

This gene was present in the common ancestor of animals.

Orthologs for MYO18A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYO18A 35
  • 90.91 (n)
  • 95.24 (a)
MYO18A 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYO18A 35
  • 91.53 (n)
  • 96.33 (a)
MYO18A 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo18a 35
  • 88.71 (n)
  • 94.69 (a)
Myo18a 16
Myo18a 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myo18a 35
  • 89 (n)
  • 94.7 (a)
oppossum
(Monodelphis domestica)
Mammalia MYO18A 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYO18A 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYO18A 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYO18A 35
  • 80.87 (n)
  • 85.13 (a)
MYO18A 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYO18A 36
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii myo18ab 35
  • 74.51 (n)
  • 79.37 (a)
myo18aa 36
  • 58 (a)
OneToMany
myo18ab 36
  • 63 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011138 35
  • 51.84 (n)
  • 41.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mhcl 35
  • 51.82 (n)
  • 42.72 (a)
Mhcl 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
ManyToMany
Species with no ortholog for MYO18A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO18A Gene

ENSEMBL:
Gene Tree for MYO18A (if available)
TreeFam:
Gene Tree for MYO18A (if available)

Paralogs for MYO18A Gene

Paralogs for MYO18A Gene

(13) SIMAP similar genes for MYO18A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MYO18A: view

Variants for MYO18A Gene

Sequence variations from dbSNP and Humsavar for MYO18A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs8076604 - 29,111,451(+) GGGGG(A/G)CATTC reference, missense
rs168377 -- 29,100,285(+) GTGCA(C/G)AGGAA intron-variant
rs180965 -- 29,135,709(+) ACACA(C/G)ATGTG intron-variant
rs180967 -- 29,085,847(+) CTCCC(C/G)TGCCC intron-variant
rs180968 -- 29,079,465(+) TGAAG(C/G)ACAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO18A Gene

Variant ID Type Subtype PubMed ID
nsv833408 CNV Loss 17160897
nsv908029 CNV Loss 21882294
nsv908030 CNV Loss 21882294
nsv2020 CNV Loss 18451855

Variation tolerance for MYO18A Gene

Residual Variation Intolerance Score: 24.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.77; 66.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYO18A Gene

Human Gene Mutation Database (HGMD)
MYO18A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO18A Gene

Disorders for MYO18A Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYO18A Gene - From: GeneCards

Disorder Aliases PubMed IDs
8p11 myeloproliferative syndrome
  • chromosome 8p11 myeloproliferative syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MYO18A

Genetic Association Database (GAD)
MYO18A
Human Genome Epidemiology (HuGE) Navigator
MYO18A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO18A
genes like me logo Genes that share disorders with MYO18A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYO18A Gene

Publications for MYO18A Gene

  1. Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A). (PMID: 12761286) Mori K. … Obinata M. (J. Biochem. 2003) 2 3 4 67
  2. The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site. (PMID: 15835906) Isogawa Y. … Sutoh K. (Biochemistry 2005) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3

Products for MYO18A Gene

Sources for MYO18A Gene

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