Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MYO18A Gene

Aliases for MYO18A Gene

  • Myosin XVIIIA 2 3
  • Molecule Associated With JAK3 N-Terminus 3 4
  • Myosin Containing A PDZ Domain 3 4
  • SPR210 3 6
  • MYSPDZ 3 4
  • MAJN 3 4
  • SP-A Receptor Subunit SP-R210 AlphaS 3
  • Myosin Containing PDZ Domain 3
  • Unconventional Myosin-XVIIIa 3
  • Myosin-XVIIIa 3
  • Myosin 18A 3
  • KIAA0216 4

External Ids for MYO18A Gene

Previous GeneCards Identifiers for MYO18A Gene

  • GC17M027547
  • GC17M024425
  • GC17M027400
  • GC17M023608

Summaries for MYO18A Gene

GeneCards Summary for MYO18A Gene

MYO18A (Myosin XVIIIA) is a Protein Coding gene. Diseases associated with MYO18A include 8p11 myeloproliferative syndrome. Among its related pathways are Signaling by FGFR and Signaling by FGFR1 mutants. GO annotations related to this gene include ATPase activity and motor activity. An important paralog of this gene is MYO18B.

UniProtKB/Swiss-Prot for MYO18A Gene

  • May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact.

Gene Wiki entry for MYO18A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO18A Gene

Genomics for MYO18A Gene

Regulatory Elements for MYO18A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MYO18A Gene

Start:
29,073,510 bp from pter
End:
29,180,412 bp from pter
Size:
106,903 bases
Orientation:
Minus strand

Genomic View for MYO18A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYO18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO18A Gene

Proteins for MYO18A Gene

  • Protein details for MYO18A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92614-MY18A_HUMAN
    Recommended name:
    Unconventional myosin-XVIIIa
    Protein Accession:
    Q92614
    Secondary Accessions:
    • Q5H9U3
    • Q5W9F9
    • Q5W9G1
    • Q8IXP8

    Protein attributes for MYO18A Gene

    Size:
    2054 amino acids
    Molecular mass:
    233115 Da
    Quaternary structure:
    • Homodimer. Forms a tripartite complex with CDC42BPA/CDC42BPB and LURAP1 with the latter acting as an adapter connecting CDC42BPA/CDC42BPB and MYO18A. Binds F-actin; regulated by ADP and GOLPH3. Interacts with GOLPH3; the interaction is direct and may link Golgi membranes to the actin cytoskeleton. Interacts with JAK3.
    SequenceCaution:
    • Sequence=BAA13206.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD66838.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MYO18A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO18A Gene

Proteomics data for MYO18A Gene at MOPED

Post-translational modifications for MYO18A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYO18A Gene

No data available for DME Specific Peptides for MYO18A Gene

Domains for MYO18A Gene

Gene Families for MYO18A Gene

HGNC:
  • MYOXVIII :Myosins / Myosin superfamily : Class XVIII

Graphical View of Domain Structure for InterPro Entry

Q92614

UniProtKB/Swiss-Prot:

MY18A_HUMAN :
  • Q92614
Domain:
  • The myosin motor domain binds ADP and ATP but has no intrinsic ATPase activity. Mediates ADP-dependent binding to actin (PubMed:23990465).
  • Contains 1 IQ domain.
  • Contains 1 myosin motor domain.
  • Contains 1 PDZ (DHR) domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO18A: view

Function for MYO18A Gene

Molecular function for MYO18A Gene

UniProtKB/Swiss-Prot Function: May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact.

Gene Ontology (GO) - Molecular Function for MYO18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003774 motor activity IEA --
GO:0005515 protein binding IPI 19837035
GO:0005524 ATP binding IDA 23990465
GO:0008094 DNA-dependent ATPase activity --
genes like me logo Genes that share ontologies with MYO18A: view

Animal Model Products

miRNA for MYO18A Gene

miRTarBase miRNAs that target MYO18A

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYO18A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MYO18A Gene

Localization for MYO18A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO18A Gene

Isoform 1: Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasm, cytoskeleton. Note=Colocalizes with actin.
Isoform 2: Cytoplasm. Note=Lacks the PDZ domain. Diffusely localized in the cytoplasm.
Golgi apparatus. Golgi apparatus, trans-Golgi network. Note=Recruited to the Golgi apparatus by GOLPH3.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO18A Gene COMPARTMENTS Subcellular localization image for MYO18A gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for MYO18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IMP 19837035
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
GO:0005802 trans-Golgi network IDA 19837035
GO:0005856 cytoskeleton --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with MYO18A: view

Pathways for MYO18A Gene

genes like me logo Genes that share pathways with MYO18A: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MYO18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006259 DNA metabolic process IEA --
GO:0007030 Golgi organization IMP 19837035
GO:0016477 cell migration IMP 18854160
GO:0031032 actomyosin structure organization IMP 18854160
GO:0038032 termination of G-protein coupled receptor signaling pathway --
genes like me logo Genes that share ontologies with MYO18A: view

Compounds for MYO18A Gene

(1) Novoseek inferred chemical compound relationships for MYO18A Gene

Compound -log(P) Hits PubMed IDs
tyrosine 25.1 2
genes like me logo Genes that share compounds with MYO18A: view

Transcripts for MYO18A Gene

Unigene Clusters for MYO18A Gene

Myosin XVIIIA:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYO18A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MYO18A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYO18A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c · 16d ^ 17a ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - -
SP4:
SP5: - - - - - - - - - - -
SP6: - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

ExUns: 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37a ·
SP1: - - -
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

ExUns: 37b ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45a · 45b ^ 46 ^ 47 ^ 48a · 48b ^ 49a · 49b ^ 50a · 50b · 50c · 50d ^ 51 ^ 52 ^ 53a · 53b · 53c
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - -
SP13: -
SP14: - -
SP15: - - - - -
SP16:
SP17: -
SP18:

Relevant External Links for MYO18A Gene

GeneLoc Exon Structure for
MYO18A
ECgene alternative splicing isoforms for
MYO18A

Expression for MYO18A Gene

mRNA expression in normal human tissues for MYO18A Gene

mRNA differential expression in normal tissues according to GTEx for MYO18A Gene

This gene is overexpressed in Muscle - Skeletal (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYO18A Gene

SOURCE GeneReport for Unigene cluster for MYO18A Gene Hs.462590

genes like me logo Genes that share expressions with MYO18A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MYO18A Gene

Orthologs for MYO18A Gene

This gene was present in the common ancestor of animals.

Orthologs for MYO18A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO18A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYO18A 35
  • 90.91 (n)
  • 95.24 (a)
MYO18A 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYO18A 35
  • 91.53 (n)
  • 96.33 (a)
MYO18A 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo18a 35
  • 88.71 (n)
  • 94.69 (a)
Myo18a 16
Myo18a 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYO18A 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYO18A 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myo18a 35
  • 89 (n)
  • 94.7 (a)
chicken
(Gallus gallus)
Aves MYO18A 35
  • 80.87 (n)
  • 85.13 (a)
MYO18A 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYO18A 36
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii myo18aa 36
  • 58 (a)
OneToMany
myo18ab 35
  • 74.51 (n)
  • 79.37 (a)
myo18ab 36
  • 63 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011138 35
  • 51.84 (n)
  • 41.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mhcl 35
  • 51.82 (n)
  • 42.72 (a)
Mhcl 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
ManyToMany
Species with no ortholog for MYO18A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO18A Gene

ENSEMBL:
Gene Tree for MYO18A (if available)
TreeFam:
Gene Tree for MYO18A (if available)

Paralogs for MYO18A Gene

Paralogs for MYO18A Gene

Selected SIMAP similar genes for MYO18A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MYO18A: view

Variants for MYO18A Gene

Sequence variations from dbSNP and Humsavar for MYO18A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs168377 -- 29,100,285(+) GTGCA(C/G)AGGAA intron-variant
rs168378 -- 29,147,779(+) gtagt(C/T)ttagc intron-variant
rs173247 -- 29,162,355(-) CACTA(G/T)GAGGC intron-variant
rs180965 -- 29,135,709(+) ACACA(C/G)ATGTG intron-variant
rs180966 -- 29,154,642(-) GCACA(C/G)GCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO18A Gene

Variant ID Type Subtype PubMed ID
nsv833408 CNV Loss 17160897
nsv908029 CNV Loss 21882294
nsv908030 CNV Loss 21882294
nsv2020 CNV Loss 18451855

Relevant External Links for MYO18A Gene

HapMap Linkage Disequilibrium report
MYO18A
Human Gene Mutation Database (HGMD)
MYO18A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO18A Gene

Disorders for MYO18A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MYO18A Gene including...

Search for MYO18A Gene in MalaCards »

Relevant External Links for MYO18A

Genetic Association Database (GAD)
MYO18A
Human Genome Epidemiology (HuGE) Navigator
MYO18A
genes like me logo Genes that share disorders with MYO18A: view

No data available for UniProtKB/Swiss-Prot for MYO18A Gene

Publications for MYO18A Gene

  1. The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site. (PMID: 15835906) Isogawa Y. … Sutoh K. (Biochemistry 2005) 3 4 23
  2. Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A). (PMID: 12761286) Mori K. … Obinata M. (J. Biochem. 2003) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Alternative splice variants encoding unstable protein domains exist in the human brain. (PMID: 15491607) Homma K. … Nishikawa K. (J. Mol. Biol. 2004) 3 4
  5. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4

Products for MYO18A Gene

Sources for MYO18A Gene

Back to Top

Content