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Aliases for MYO18A Gene

Aliases for MYO18A Gene

  • Myosin XVIIIA 2 3 5
  • Molecule Associated With JAK3 N-Terminus 3 4
  • Surfactant Protein Receptor SP-R210 3 4
  • Myosin Containing A PDZ Domain 3 4
  • SP-R210 3 4
  • MYSPDZ 3 4
  • MAJN 3 4
  • SP-A Receptor Subunit SP-R210 AlphaS 3
  • Myosin Containing PDZ Domain 3
  • Unconventional Myosin-XVIIIa 3
  • Myosin 18A 3
  • KIAA0216 4
  • SPR210 3
  • CD245 4

External Ids for MYO18A Gene

Previous GeneCards Identifiers for MYO18A Gene

  • GC17M027547
  • GC17M024425
  • GC17M027400
  • GC17M023608

Summaries for MYO18A Gene

Entrez Gene Summary for MYO18A Gene

  • The protein encoded by this gene can bind GOLPH3, linking the Golgi to the cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. [provided by RefSeq, Oct 2016]

GeneCards Summary for MYO18A Gene

MYO18A (Myosin XVIIIA) is a Protein Coding gene. Diseases associated with MYO18A include 8P11 Myeloproliferative Syndrome. Among its related pathways are HIV Life Cycle and FGFR1 mutant receptor activation. GO annotations related to this gene include poly(A) RNA binding and actin filament binding. An important paralog of this gene is MYO18B.

UniProtKB/Swiss-Prot for MYO18A Gene

  • May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939).

Gene Wiki entry for MYO18A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO18A Gene

Genomics for MYO18A Gene

Regulatory Elements for MYO18A Gene

Enhancers for MYO18A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F029153 0.9 Ensembl ENCODE 40 +23.2 23221 7.6 HDGF PKNOX1 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 ZNF121 GLIS2 MYO18A CRYBA1 TIAF1 PROCA1 LOC105371717
GH17F029146 0.9 FANTOM5 ENCODE 39.8 +30.7 30709 6.7 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 MYO18A ENSG00000265289 NUFIP2 ENSG00000264647 MIR4723 TIAF1 NDUFS5P7 LOC105371715 LOC105371716 ENSG00000266111
GH17F029136 1.3 FANTOM5 ENCODE 39.7 +40.8 40814 5.8 PKNOX1 ARNT FEZF1 ZNF121 GATA2 FOS SP3 JUNB NCOA1 REST MYO18A TIAF1 RAB34 LOC105371717 GC17M029081
GH17F029123 0.7 Ensembl ENCODE 38.5 +54.5 54473 4.5 TBP WRNIP1 ARID4B NFXL1 RAD21 SCRT2 ZNF143 RCOR1 ZNF263 SMARCC1 MYO18A TIAF1 LOC105371717 GC17M029081
GH17F029175 0.9 FANTOM5 ENCODE 31.9 +1.8 1795 5.7 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 YBX1 YY1 SLC30A9 MYO18A IFT20 ENSG00000264044 MIR4723 TIAF1 ENSG00000265474 TLCD1 TRAF4 GIT1 LOC105371717
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MYO18A on UCSC Golden Path with GeneCards custom track

Promoters for MYO18A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001806189 412 1601 HDGF PKNOX1 ARID4B SIN3A DMAP1 YBX1 YY1 SLC30A9 CBX5 ZNF207

Genomic Location for MYO18A Gene

Chromosome:
17
Start:
29,071,124 bp from pter
End:
29,180,412 bp from pter
Size:
109,289 bases
Orientation:
Minus strand

Genomic View for MYO18A Gene

Genes around MYO18A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO18A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO18A Gene

Proteins for MYO18A Gene

  • Protein details for MYO18A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92614-MY18A_HUMAN
    Recommended name:
    Unconventional myosin-XVIIIa
    Protein Accession:
    Q92614
    Secondary Accessions:
    • Q5H9U3
    • Q5QD01
    • Q5W9F9
    • Q5W9G1
    • Q8IXP8

    Protein attributes for MYO18A Gene

    Size:
    2054 amino acids
    Molecular mass:
    233115 Da
    Quaternary structure:
    • Homodimer. Forms a tripartite complex with CDC42BPA/CDC42BPB and LURAP1 with the latter acting as an adapter connecting CDC42BPA/CDC42BPB and MYO18A. Binds F-actin; regulated by ADP and GOLPH3. Interacts with GOLPH3; the interaction is direct and may link Golgi membranes to the actin cytoskeleton. Interacts with JAK3. Interacts with MSR1 and CD14 (PubMed:25965346). Isoform 5 interacts with CD11B (PubMed:25965346).
    SequenceCaution:
    • Sequence=BAA13206.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD66838.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MYO18A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO18A Gene

Post-translational modifications for MYO18A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYO18A Gene

Domains & Families for MYO18A Gene

Gene Families for MYO18A Gene

Graphical View of Domain Structure for InterPro Entry

Q92614

UniProtKB/Swiss-Prot:

MY18A_HUMAN :
  • The myosin motor domain binds ADP and ATP but has no intrinsic ATPase activity. Mediates ADP-dependent binding to actin (PubMed:23990465).
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • The myosin motor domain binds ADP and ATP but has no intrinsic ATPase activity. Mediates ADP-dependent binding to actin (PubMed:23990465).
  • Contains 1 IQ domain.
  • Contains 1 myosin motor domain.
  • Contains 1 PDZ (DHR) domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO18A: view

Function for MYO18A Gene

Molecular function for MYO18A Gene

UniProtKB/Swiss-Prot Function:
May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939).

Gene Ontology (GO) - Molecular Function for MYO18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003677 DNA binding IEA --
GO:0003774 motor activity IEA --
GO:0005515 protein binding IPI 19837035
GO:0005524 ATP binding IEA,IDA 23990465
genes like me logo Genes that share ontologies with MYO18A: view
genes like me logo Genes that share phenotypes with MYO18A: view

Animal Models for MYO18A Gene

MGI Knock Outs for MYO18A:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYO18A Gene

Localization for MYO18A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO18A Gene

Isoform 1: Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasm, cytoskeleton. Note=Colocalizes with actin.
Isoform 2: Cytoplasm. Note=Lacks the PDZ domain. Diffusely localized in the cytoplasm.
Golgi apparatus. Golgi apparatus, trans-Golgi network. Note=Recruited to the Golgi apparatus by GOLPH3.
Isoform 5: Cell surface.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO18A Gene COMPARTMENTS Subcellular localization image for MYO18A gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MYO18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
GO:0005794 Golgi apparatus IEA,IDA --
genes like me logo Genes that share ontologies with MYO18A: view

Pathways & Interactions for MYO18A Gene

genes like me logo Genes that share pathways with MYO18A: view

Gene Ontology (GO) - Biological Process for MYO18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006259 DNA metabolic process IEA --
GO:0007030 Golgi organization IMP 19837035
GO:0016477 cell migration IMP 18854160
GO:0031032 actomyosin structure organization IMP 18854160
GO:0043030 regulation of macrophage activation IMP 25965346
genes like me logo Genes that share ontologies with MYO18A: view

No data available for SIGNOR curated interactions for MYO18A Gene

Drugs & Compounds for MYO18A Gene

(1) Drugs for MYO18A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MYO18A: view

Transcripts for MYO18A Gene

Unigene Clusters for MYO18A Gene

Myosin XVIIIA:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYO18A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c · 16d ^ 17a ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - -
SP4:
SP5: - - - - - - - - - - -
SP6: - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

ExUns: 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37a ·
SP1: - - -
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

ExUns: 37b ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45a · 45b ^ 46 ^ 47 ^ 48a · 48b ^ 49a · 49b ^ 50a · 50b · 50c · 50d ^ 51 ^ 52 ^ 53a · 53b · 53c
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - -
SP13: -
SP14: - -
SP15: - - - - -
SP16:
SP17: -
SP18:

Relevant External Links for MYO18A Gene

GeneLoc Exon Structure for
MYO18A
ECgene alternative splicing isoforms for
MYO18A

Expression for MYO18A Gene

mRNA expression in normal human tissues for MYO18A Gene

mRNA differential expression in normal tissues according to GTEx for MYO18A Gene

This gene is overexpressed in Muscle - Skeletal (x7.7).

Protein differential expression in normal tissues from HIPED for MYO18A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.8), Cervix (7.4), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYO18A Gene



Protein tissue co-expression partners for MYO18A Gene

NURSA nuclear receptor signaling pathways regulating expression of MYO18A Gene:

MYO18A

SOURCE GeneReport for Unigene cluster for MYO18A Gene:

Hs.462590
genes like me logo Genes that share expression patterns with MYO18A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MYO18A Gene

Orthologs for MYO18A Gene

This gene was present in the common ancestor of animals.

Orthologs for MYO18A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO18A 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYO18A 34 35
  • 91.53 (n)
cow
(Bos Taurus)
Mammalia MYO18A 34 35
  • 90.91 (n)
rat
(Rattus norvegicus)
Mammalia Myo18a 34
  • 89 (n)
mouse
(Mus musculus)
Mammalia Myo18a 34 16 35
  • 88.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MYO18A 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYO18A 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYO18A 34 35
  • 80.87 (n)
lizard
(Anolis carolinensis)
Reptilia MYO18A 35
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii myo18ab 34 35
  • 74.51 (n)
myo18aa 35
  • 58 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011138 34
  • 51.84 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mhcl 34 35
  • 51.82 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
ManyToMany
Species where no ortholog for MYO18A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO18A Gene

ENSEMBL:
Gene Tree for MYO18A (if available)
TreeFam:
Gene Tree for MYO18A (if available)

Paralogs for MYO18A Gene

Paralogs for MYO18A Gene

(13) SIMAP similar genes for MYO18A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MYO18A: view

Variants for MYO18A Gene

Sequence variations from dbSNP and Humsavar for MYO18A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs755153578 Uncertain significance 29,166,901(+) CCGCC(C/T)GCCAT reference, missense
rs10153246 -- 29,133,643(+) ACCAG(C/T)CCCCG intron-variant
rs10438791 -- 29,144,759(+) ACATA(C/T)GGTTC intron-variant
rs10438797 -- 29,164,844(+) CTCCT(G/T)CTGCT intron-variant
rs10459959 -- 29,109,222(+) gcctg(C/G)ctggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO18A Gene

Variant ID Type Subtype PubMed ID
esv3554290 CNV deletion 23714750
esv3640320 CNV loss 21293372
nsv2020 CNV deletion 18451855
nsv833408 CNV loss 17160897
nsv953872 CNV deletion 24416366

Variation tolerance for MYO18A Gene

Residual Variation Intolerance Score: 24.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.77; 66.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYO18A Gene

Human Gene Mutation Database (HGMD)
MYO18A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYO18A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO18A Gene

Disorders for MYO18A Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYO18A Gene - From: GeneCards

Disorder Aliases PubMed IDs
8p11 myeloproliferative syndrome
  • chromosome 8p11 myeloproliferative syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MYO18A

Genetic Association Database (GAD)
MYO18A
Human Genome Epidemiology (HuGE) Navigator
MYO18A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO18A
genes like me logo Genes that share disorders with MYO18A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYO18A Gene

Publications for MYO18A Gene

  1. The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site. (PMID: 15835906) Isogawa Y. … Sutoh K. (Biochemistry 2005) 3 4 22 64
  2. Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A). (PMID: 12761286) Mori K. … Obinata M. (J. Biochem. 2003) 2 3 4 64
  3. SP-R210 (Myo18A) isoforms as intrinsic modulators of macrophage priming and activation. (PMID: 25965346) Yang L. … Chroneos Z.C. (PLoS ONE 2015) 3 4 64
  4. GOLPH3L antagonizes GOLPH3 to determine Golgi morphology. (PMID: 23345592) Ng M.M. … Field S.J. (Mol. Biol. Cell 2013) 3 4 64
  5. Functional Characterization of Human Myosin-18A and its Interaction with F-actin and GOLPH3. (PMID: 23990465) Taft M.H. … Manstein D.J. (J. Biol. Chem. 2013) 3 4 64

Products for MYO18A Gene

Sources for MYO18A Gene

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