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MYO18A Gene

protein-coding   GIFtS: 55
GCID: GC17M027400

Myosin XVIIIA

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin XVIIIA1 2     Myosin 18A2
Molecule Associated With JAK3 N-Terminus2 3     Myosin Containing PDZ Domain2
Myosin Containing A PDZ Domain2 3     myosin-XVIIIa2
MAJN2 3     SP-A Receptor Subunit SP-R210 AlphaS2
MYSPDZ2 3     Unconventional Myosin-XVIIIa2
SPR2102 5     KIAA02163

External Ids:    HGNC: 311041   Entrez Gene: 3996872   Ensembl: ENSG000001965357   OMIM: 6100675   UniProtKB: Q926143   

Export aliases for MYO18A gene to outside databases

Previous GC identifers: GC17M027547 GC17M024425 GC17M023608


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYO18A Gene:
MYO18A (myosin XVIIIA) is a protein-coding gene. Diseases associated with MYO18A include 8p11 myeloproliferative syndrome, and vesicoureteral reflux. GO annotations related to this gene include motor activity and ATPase activity. An important paralog of this gene is MYO18B.

UniProtKB/Swiss-Prot: MY18A_HUMAN, Q92614
Function: May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle
budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its
flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been
involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May
be involved in the maintenance of the stromal cell architectures required for cell to cell contact

Gene Wiki entry for MYO18A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYO18A gene promoter:
         Spz1   Pax-5   Sp1   SREBP-1c   MyoD   Nkx5-1   SREBP-1b   FAC1   SREBP-1a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): MYO18A promoter sequence
   Search Chromatin IP Primers for MYO18A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYO18A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

MYO18A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYO18A gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M027400:  view genomic region     (about GC identifiers)

Start:
27,400,528 bp from pter      End:
27,507,430 bp from pter
Size:
106,903 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MY18A_HUMAN, Q92614 (See protein sequence)
Recommended Name: Unconventional myosin-XVIIIa  
Size: 2054 amino acids; 233115 Da
Subunit: Homodimer. Forms a tripartite complex with CDC42BPA/CDC42BPB and LURAP1 with the latter acting as an
adapter connecting CDC42BPA/CDC42BPB and MYO18A. Binds F-actin; regulated by ADP and GOLPH3. Interacts with
GOLPH3; the interaction is direct and may link Golgi membranes to the actin cytoskeleton. Interacts with JAK3
Caution: The TIAF1 protein is coded in the 3'-UTR region of MYO18A
Sequence caution: Sequence=BAA13206.2; Type=Erroneous initiation; Sequence=BAD66838.1; Type=Erroneous initiation;
Secondary accessions: Q5H9U3 Q5W9F9 Q5W9G1 Q8IXP8
Alternative splicing: 5 isoforms:  Q92614-1   Q92614-2   Q92614-3   Q92614-4   Q92614-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MYO18A: NX_Q92614

Explore proteomics data for MYO18A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYO18A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_510880.2  NP_976063.1  

    ENSEMBL proteins: 
     ENSP00000435932   ENSP00000434228   ENSP00000437073   ENSP00000434817   ENSP00000465542  
     ENSP00000436660   ENSP00000346291  
    Reactome Protein details: Q92614

    MYO18A Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYO18A

    MYO18A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MYO18A
    Novus Biologicals MYO18A Antibodies
    Abcam antibodies for MYO18A
    Cloud-Clone Corp. Antibodies for MYO18A
    Search ThermoFisher Antibodies for MYO18A
    Search LSBio for Antibodies for MYO18A

    MYO18A Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MYO18A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MYO18A
    Cloud-Clone Corp. CLIAs for MYO18A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MYOXVIII: Myosins / Myosin superfamily : Class XVIII

    Selected InterPro protein domains (see all 8):
     IPR027401 Myosin-like_IQ_dom
     IPR020587 RecA_monomer-monomer_interface
     IPR027417 P-loop_NTPase
     IPR001478 PDZ
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry Q92614

    ProtoNet protein and cluster: Q92614

    2 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB003345 M protein repeat


    UniProtKB/Swiss-Prot: MY18A_HUMAN, Q92614
    Domain: The myosin head-like domain binds ADP and ATP but has no intrinsic ATPase activity. Mediates ADP-dependent
    binding to actin (PubMed:23990465)
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 myosin head-like domain
    Similarity: Contains 1 PDZ (DHR) domain


    MYO18A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MY18A_HUMAN, Q92614
    Function: May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle
    budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its
    flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been
    involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May
    be involved in the maintenance of the stromal cell architectures required for cell to cell contact

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003774motor activity IEA--
    GO:0005515protein binding IPI19837035
    GO:0005524ATP binding IDA--
    GO:0008094DNA-dependent ATPase activity ----
         
    MYO18A for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Myo18a (no phenotypes)

    MYO18A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYO18A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYO18A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYO18A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYO18A

    miRNA
    Products:
        
    miRTarBase miRNAs that target MYO18A:
    hsa-mir-193b-3p (MIRT041599), hsa-mir-1 (MIRT023968), hsa-mir-335-5p (MIRT018699)

    Block miRNA regulation of human, mouse, rat MYO18A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYO18A (see all 24):
    hsa-miR-125a-5p hsa-miR-331-3p hsa-miR-3154 hsa-miR-125b hsa-miR-3649 hsa-miR-3174 hsa-miR-761 hsa-miR-635
    SwitchGear 3'UTR luciferase reporter plasmidMYO18A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MYO18A
    Predesigned siRNA for gene silencing in human, mouse, rat MYO18A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MYO18A

    Clone
    Products:
         
    OriGene clones in human, mouse for MYO18A (see all 9)
    OriGene ORF clones in mouse, rat for MYO18A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MYO18A (NM_078471)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYO18A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYO18A

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MYO18A
    Browse ESI BIO Cell Lines and PureStem Progenitors for MYO18A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO18A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MY18A_HUMAN, Q92614: Isoform 1: Endoplasmic reticulum-Golgi intermediate compartment (By similarity). Cytoplasm,
    cytoskeleton. Note=Colocalizes with actin
    MY18A_HUMAN, Q92614: Isoform 2: Cytoplasm. Note=Lacks the PDZ domain. Diffusely localized in the cytoplasm
    MY18A_HUMAN, Q92614: Golgi apparatus. Golgi apparatus, trans-Golgi network. Note=Recruited to the Golgi apparatus
    by GOLPH3
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus3
    cytosol2
    golgi apparatus2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IMP19837035
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IEA--
    GO:0005794Golgi apparatus ----
    GO:0005802trans-Golgi network IDA19837035
    GO:0005856cytoskeleton ----

    MYO18A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYO18A About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR1 mutants
    Signaling by FGFR1 mutants0.67
    Signaling by FGFR1 fusion mutants0.00
    Signaling by FGFR mutants0.67
    2Signaling by FGFR
    Signaling by FGFR in disease0.91
    3Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for MYO18A
        Signaling by FGFR1 fusion mutants



    MYO18A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MYO18A: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MYO18A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYO18A (Q926141, 3 ENSP000003462914) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOLPH3Q9H4A61, 3, ENSP000002650704EBI-949059,EBI-2465479 I2D: score=1 STRING: ENSP00000265070
    ATXN1P542533, ENSP000002447694I2D: score=2 STRING: ENSP00000244769
    MARK4Q96L343, ENSP000003008434I2D: score=2 STRING: ENSP00000300843
    CDC42BPAQ5VT253, ENSP000003557314I2D: score=1 STRING: ENSP00000355731
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006259DNA metabolic process IEA--
    GO:0007030Golgi organization IMP19837035
    GO:0016477cell migration IMP18854160
    GO:0031032actomyosin structure organization IMP18854160
    GO:0038032termination of G-protein coupled receptor signaling pathway ----

    MYO18A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYO18A (MY18A)

    1 Novoseek inferred chemical compound relationship for MYO18A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 25.1 4 14969583 (2)



    MYO18A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MYO18A gene (2 alternative transcripts): 
    NM_078471.3  NM_203318.1  

    Unigene Cluster for MYO18A:

    Myosin XVIIIA
    Hs.462590  [show with all ESTs]
    Unigene Representative Sequence: D86970
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000529578 ENST00000533112(uc010csa.1) ENST00000531253(uc010wbc.1)
    ENST00000527372(uc002hdt.1 uc002hdu.1) ENST00000530254(uc002hds.2 uc010wbd.1)
    ENST00000546105 ENST00000532867 ENST00000527312 ENST00000531438 ENST00000531892
    ENST00000529889 ENST00000530557 ENST00000533652 ENST00000532143 ENST00000533399
    ENST00000588791 ENST00000590242 ENST00000528564
    miRNA
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    Block miRNA regulation of human, mouse, rat MYO18A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYO18A (see all 24):
    hsa-miR-125a-5p hsa-miR-331-3p hsa-miR-3154 hsa-miR-125b hsa-miR-3649 hsa-miR-3174 hsa-miR-761 hsa-miR-635
    SwitchGear 3'UTR luciferase reporter plasmidMYO18A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MYO18A
    Predesigned siRNA for gene silencing in human, mouse, rat MYO18A
    Clone
    Products:
         
    OriGene clones in human, mouse for MYO18A (see all 9)
    OriGene ORF clones in mouse, rat for MYO18A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MYO18A (NM_078471)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYO18A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYO18A
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYO18A
      QuantiTect SYBR Green Assays in human, mouse, rat MYO18A
      QuantiFast Probe-based Assays in human, mouse, rat MYO18A

    Additional mRNA sequence: 

    AB177858.1 AB177860.1 AF105277.1 AF252258.1 AK294180.1 AK302505.1 AK302725.1 AK303522.1 
    AY703984.1 BC039612.1 BC047669.1 BC058075.1 BC131561.1 BC131586.1 CR933614.1 D86970.2 

    Selected DOTS entries (see all 25):

    DT.102833620  DT.100029510  DT.100818688  DT.447608  DT.100818687  DT.95225182  DT.100029511  DT.100801802 
    DT.91676723  DT.120988031  DT.86854815  DT.100818685  DT.100818691  DT.75146885  DT.120987899  DT.120987943 
    DT.120988018  DT.91846798  DT.92442605  DT.92442606  DT.92442610  DT.95225183  DT.97846576  DT.91980304 

    Selected AceView cDNA sequences (see all 311):

    BQ005000 BF197743 BQ549619 CD674438 BQ430532 AW148893 BM856397 AI270683 
    CA309726 BQ718431 BQ058479 BQ227330 AI801086 CA446539 D86970 BU849656 
    BC039612 BU543540 NM_203318 BU839435 NM_078471 AJ133824 F31497 BU191933 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MYO18A (see all 18)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c · 16d ^ 17a ·
    SP1:        -           -     -     -     -     -     -     -     -     -     -     -     -                                                                     
    SP2:                                                  -     -     -     -     -     -     -                                                                     
    SP3:                    -     -     -     -     -     -     -     -     -     -     -     -                                                                     
    SP4:                                                                                                                                                            
    SP5:                                      -     -     -     -     -     -     -     -     -                 -     -                                             

    ExUns: 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37a ·
    SP1:                                                  -                                         -                                                           -   
    SP2:                                                  -                                         -                                                           -   
    SP3:                                                  -                                         -                                                           -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 37b ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45a · 45b ^ 46 ^ 47 ^ 48a · 48b ^ 49a · 49b ^ 50a · 50b · 50c · 50d ^ 51 ^ 52 ^ 53a · 53b · 53c
    SP1:                                            -     -     -                 -                       -     -                                             
    SP2:                                            -     -     -                 -                       -     -                 -                           
    SP3:                    -                       -     -     -                 -                       -     -                 -                           
    SP4:                                                                          -                       -     -                 -                           
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for MYO18A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYO18A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MYO18A Expression
    About this image

    MYO18A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYO18A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.462590
        Pathway & Disease-focused RT2 Profiler PCR Array including MYO18A: 
              Apoptosis 384HT in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MYO18A gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myo18a1 , 5 myosin XVIIIA1, 5 88.71(n)1
    94.69(a)1
      11 (46.74 cM)5
    3600131  NM_011586.21  NP_035716.11 
     777632465 
    chicken
    (Gallus gallus)
    Aves MYO18A1 myosin XVIIIA 80.87(n)
    85.13(a)
      417581  XM_004946612.1  XP_004946669.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYO18A6
    myosin XVIIIA
    81(a)
    1 ↔ 1
    GL343462.1(126090-277251)
    zebrafish
    (Danio rerio)
    Actinopterygii myo18ab1 myosin XVIIIAb 74.51(n)
    79.37(a)
      559005  XM_005157613.1  XP_005157670.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mhcl1 Myosin heavy chain-like 51.82(n)
    42.72(a)
      41955  NM_001043250.2  NP_001036715.1 


    ENSEMBL Gene Tree for MYO18A (if available)
    TreeFam Gene Tree for MYO18A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYO18A gene
    MYO18B2  
    13 SIMAP similar genes for MYO18A using alignment to 6 protein entries:     MY18A_HUMAN (see all proteins):
    MAJN    MYH7    MYO18B    MYH10    MYH11    MYH14
    MYO1E    MYH9    MYO1B    MYH2    MYO10    MYO1A
    MYO5C

    MYO18A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYO18A (see all 2076)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs612925241,2
    C--23642881(+) AAAAA-/A/AA  
            
    GACAC
    2 -- int11NA 2
    rs718408151,2
    C--23652618(+) AGGAA-/GATAC 
            
    GGAGC
    2 -- int10--------
    rs1894087461,2
    --27404658(+) CCAATC/TCTCCT 2 -- int10--------
    rs732683131,2
    C,F--27404670(+) GGAGCG/AGGTGG 2 -- int12Minor allele frequency- A:0.08WA 120
    rs1418411151,2
    C--27404704(+) CAGCTC/TTCCTG 2 -- int10--------
    rs803263521,2
    C,F--27404749(+) AGAAAC/TAGGCT 2 -- int11Minor allele frequency- T:0.10WA 118
    rs1455841741,2
    --27404939(+) TCTCCA/CAGGTC 2 -- int10--------
    rs80751341,2
    C,F,A,H--27404953(+) CAGCTA/GACTTC 2 -- int121Minor allele frequency- G:0.46NS EA NA WA CSA 2344
    rs80804531,2
    C,F,A,H--27405044(+) TATATT/ATTTTT 2 -- int14Minor allele frequency- A:0.50WA NA CSA 8
    rs2012110341,2
    --27405044(+) TATAT-/ATTTTT 2 -- int10--------

    HapMap Linkage Disequilibrium report for MYO18A (27400528 - 27507430 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MYO18A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833408CNV Loss17160897
    nsv2020CNV Loss18451855
    nsv908030CNV Loss21882294
    nsv908029CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYO18A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610067    OMIM disorders: --

    10 diseases for MYO18A:    
    About MalaCards
    8p11 myeloproliferative syndrome    vesicoureteral reflux    eosinophilia    colon adenocarcinoma
    t-cell leukemia    tuberculosis    ataxia    adenocarcinoma
    leukemia    malaria


    MYO18A for disorders           About GeneDecksing

    Genetic Association Database (GAD): MYO18A
    Human Genome Epidemiology (HuGE) Navigator: MYO18A (1 document)

    Export disorders for MYO18A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYO18A gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with MYO18A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A). (PubMed id 12761286)1, 2, 3 Mori K.... Obinata M. (J. Biochem. 2003)
    2. The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site. (PubMed id 15835906)1, 2, 9 Isogawa Y....Sutoh K. (Biochemistry 2005)
    3. GOLPH3L antagonizes GOLPH3 to determine Golgi morphology. (PubMed id 23345592)1, 2 Ng M.M....Field S.J. (Mol. Biol. Cell 2013)
    4. Functional Characterization of Human Myosin-18A and its Interaction with F-actin and GOLPH3. (PubMed id 23990465)1, 2 Taft M.H....Manstein D.J. (J. Biol. Chem. 2013)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding. (PubMed id 19837035)1, 2 Dippold H.C....Field S.J. (Cell 2009)
    7. A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow. (PubMed id 18854160)1, 2 Tan I.... Leung T. (Cell 2008)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. Alternative splice variants encoding unstable protein domains exist in the human brain. (PubMed id 15491607)1, 2 Homma K.... Nishikawa K. (J. Mol. Biol. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 399687 HGNC: 31104 AceView: TIAF1 Ensembl:ENSG00000196535 euGenes: HUgn399687
    ECgene: MYO18A H-InvDB: MYO18A

    (According to HUGE)
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    HUGE: KIAA0216

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYO18A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYO18A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYO18A gene:
    Search GeneIP for patents involving MYO18A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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