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Aliases for MYO16 Gene

Aliases for MYO16 Gene

  • Myosin XVI 2 3
  • Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adaptor 3 2 3
  • Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adapter 3 3 4
  • Unconventional Myosin-16 3 4
  • KIAA0865 4 6
  • Myo16b 3 4
  • MYAP3 3 6
  • NYAP3 3 4
  • Protein Phosphatase 1, Regulatory Subunit 107 3
  • Unconventional Myosin-XVI 3
  • Myosin Heavy Chain Myr 8 3
  • Regulatory Subunit 107 2
  • Protein Phosphatase 1 2
  • MYO16 Variant Protein 3
  • Myosin-XVI 3
  • PPP1R107 3
  • MYR8 3

External Ids for MYO16 Gene

Summaries for MYO16 Gene

GeneCards Summary for MYO16 Gene

MYO16 (Myosin XVI) is a Protein Coding gene. GO annotations related to this gene include actin filament binding and motor activity. An important paralog of this gene is MYO7A.

UniProtKB/Swiss-Prot for MYO16 Gene

  • Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO16 Gene

Genomics for MYO16 Gene

Genomic Location for MYO16 Gene

Start:
108,596,152 bp from pter
End:
109,208,007 bp from pter
Size:
611,856 bases
Orientation:
Plus strand

Genomic View for MYO16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYO16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO16 Gene

No data available for Regulatory Elements for MYO16 Gene

Proteins for MYO16 Gene

  • Protein details for MYO16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6X6-MYO16_HUMAN
    Recommended name:
    Unconventional myosin-XVI
    Protein Accession:
    Q9Y6X6
    Secondary Accessions:
    • A6H8Y0
    • A8MTX3
    • Q5VYX4
    • Q5VYX5
    • Q5VYX6
    • Q6ZS13
    • Q8N3C2
    • Q8N948

    Protein attributes for MYO16 Gene

    Size:
    1858 amino acids
    Molecular mass:
    206129 Da
    Quaternary structure:
    • Binds PPP1CA and/or PPP1CC. Binds F-actin in an ATP-sensitive manner. Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity).
    SequenceCaution:
    • Sequence=BAA74888.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC04608.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC87143.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MYO16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO16 Gene

Proteomics data for MYO16 Gene at MOPED

Post-translational modifications for MYO16 Gene

  • Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYO16 Gene

No data available for DME Specific Peptides for MYO16 Gene

Domains for MYO16 Gene

Gene Families for MYO16 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • MYOXVI :Myosins / Myosin superfamily : Class XVI

UniProtKB/Swiss-Prot:

MYO16_HUMAN
Domain:
  • Contains 1 IQ domain.:
    • Q9Y6X6
  • Contains 1 myosin motor domain.:
    • Q9Y6X6
Family:
  • In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.:
    • Q9Y6X6
  • In the C-terminal section; belongs to the NYAP family.:
    • Q9Y6X6
Similarity:
  • Contains 7 ANK repeats.:
    • Q9Y6X6
genes like me logo Genes that share domains with MYO16: view

Function for MYO16 Gene

Molecular function for MYO16 Gene

UniProtKB/Swiss-Prot Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for MYO16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0019903 protein phosphatase binding --
genes like me logo Genes that share ontologies with MYO16: view

Phenotypes for MYO16 Gene

GenomeRNAi human phenotypes for MYO16:
genes like me logo Genes that share phenotypes with MYO16: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MYO16 Gene

Localization for MYO16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO16 Gene

Cytoplasm. Note=Found in puncta in soma and processes of astrocytes and dissociated cerebellar cells with the morphology of migrating granule cells. {ECO:0000250 UniProtKB:Q9ERC1}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO16 Gene COMPARTMENTS Subcellular localization image for MYO16 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MYO16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA 17029291
GO:0005737 cytoplasm ISS 11588169
GO:0005829 cytosol --
GO:0005886 plasma membrane ISS 11588169
GO:0016020 membrane --
genes like me logo Genes that share ontologies with MYO16: view

Pathways for MYO16 Gene

SuperPathways for MYO16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYO16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0008285 negative regulation of cell proliferation ISS 17029291
GO:0014065 phosphatidylinositol 3-kinase signaling --
GO:0021549 cerebellum development ISS 11588169
GO:0048812 neuron projection morphogenesis --
genes like me logo Genes that share ontologies with MYO16: view

No data available for Pathways by source for MYO16 Gene

Transcripts for MYO16 Gene

Unigene Clusters for MYO16 Gene

Myosin XVI:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYO16 Gene

No ASD Table

Relevant External Links for MYO16 Gene

GeneLoc Exon Structure for
MYO16
ECgene alternative splicing isoforms for
MYO16

Expression for MYO16 Gene

mRNA expression in normal human tissues for MYO16 Gene

mRNA differential expression in normal tissues according to GTEx for MYO16 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYO16 Gene

SOURCE GeneReport for Unigene cluster for MYO16 Gene Hs.656587

genes like me logo Genes that share expressions with MYO16: view

Orthologs for MYO16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYO16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO16 36
  • 99.24 (n)
  • 98.99 (a)
MYO16 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYO16 36
  • 75.42 (n)
  • 72.56 (a)
MYO16 37
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYO16 36
  • 85.57 (n)
  • 85.54 (a)
MYO16 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo16 36
  • 77.72 (n)
  • 77.77 (a)
Myo16 16
Myo16 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYO16 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYO16 37
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYO16 36
  • 73.04 (n)
  • 74.76 (a)
MYO16 37
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myo16 36
  • 64.16 (n)
  • 62.97 (a)
zebrafish
(Danio rerio)
Actinopterygii myo16 36
  • 61.14 (n)
  • 58.19 (a)
myo16 37
  • 54 (a)
OneToOne
Species with no ortholog for MYO16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO16 Gene

ENSEMBL:
Gene Tree for MYO16 (if available)
TreeFam:
Gene Tree for MYO16 (if available)

Paralogs for MYO16 Gene

Paralogs for MYO16 Gene

Selected SIMAP similar genes for MYO16 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MYO16: view

Variants for MYO16 Gene

Sequence variations from dbSNP and Humsavar for MYO16 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs17517 -- 109,138,074(-) ATATG(C/T)ATTCA intron-variant
rs149726 -- 108,739,542(-) aggtc(A/G)ggtta intron-variant
rs149727 -- 108,751,662(-) gagac(C/T)tgact intron-variant
rs149728 -- 108,749,441(-) tctta(A/T)ttggg intron-variant
rs149729 -- 108,748,351(-) ttgat(G/T)ttgct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO16 Gene

Variant ID Type Subtype PubMed ID
esv2747975 CNV Deletion 23290073
nsv1178 CNV Insertion 18451855
esv2747977 CNV Deletion 23290073
esv2747978 CNV Deletion 23290073
nsv509515 CNV Insertion 20534489
nsv1179 CNV Insertion 18451855
esv994778 CNV Insertion 20482838
esv2632168 CNV Deletion 19546169
esv2395984 CNV Deletion 18987734
nsv512336 CNV Loss 21212237
esv5193 CNV Deletion 18987735
esv2747979 CNV Deletion 23290073
esv9706 CNV Loss 19470904
esv26162 CNV Gain+Loss 19812545
nsv821014 CNV Deletion 20802225
nsv826784 CNV Loss 20364138
esv997483 CNV Gain 20482838
nsv826785 CNV Gain+Loss 20364138
nsv826787 CNV Gain 20364138
esv23749 CNV Gain 19812545
esv2589356 CNV Deletion 19546169
esv2747980 CNV Deletion 23290073
esv3381 CNV Deletion 18987735
nsv9105 CNV Loss 18304495
nsv9106 CNV Loss 18304495
nsv832717 CNV Loss 17160897
esv990061 CNV Insertion 20482838
esv1152422 CNV Insertion 17803354
esv2367242 CNV Deletion 18987734
esv2747981 CNV Deletion 23290073
esv1656960 CNV Deletion 17803354
esv2747982 CNV Deletion 23290073
esv998130 CNV Deletion 20482838
nsv64924 CNV Loss 16902084
nsv525337 CNV Loss 19592680
nsv901002 CNV Loss 21882294
esv1695062 CNV Insertion 17803354
esv1038256 CNV Insertion 17803354
esv28586 CNV Loss 19812545
nsv901003 CNV Loss 21882294
nsv819031 CNV Gain 19587683
nsv832718 CNV Gain 17160897
esv2657985 CNV Deletion 23128226
nsv510366 CNV Loss 20534489
esv267654 CNV Insertion 20981092

Relevant External Links for MYO16 Gene

HapMap Linkage Disequilibrium report
MYO16

Disorders for MYO16 Gene

Relevant External Links for MYO16

Genetic Association Database (GAD)
MYO16
Human Genome Epidemiology (HuGE) Navigator
MYO16
genes like me logo Genes that share disorders with MYO16: view

No data available for UniProtKB/Swiss-Prot for MYO16 Gene

Publications for MYO16 Gene

  1. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3 49
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  4. NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. (PMID: 21946561) Yokoyama K. … Yamamoto T. (EMBO J. 2011) 2 3
  5. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4

Products for MYO16 Gene

Sources for MYO16 Gene

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