Aliases for MYO16 Gene
External Ids for MYO16 Gene
Previous GeneCards Identifiers for MYO16 Gene
This gene encodes an unconventional myosin protein. The encoded protein has been proposed to act as a serine/threonine phosphatase-1 targeting or regulatory subunit. Studies in a rat cell line suggest that this protein may regulate cell cycle progression. A variant within this gene may be associated with susceptibility to schizophrenia and elevated expression of this gene has been observed in the frontal cortex of human schizophrenia patients. [provided by RefSeq, Mar 2017]
GeneCards Summary for MYO16 Gene
MYO16 (Myosin XVI) is a Protein Coding gene. GO annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is NYAP2.
UniProtKB/Swiss-Prot for MYO16 Gene
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity).