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Aliases for MYO16 Gene

Aliases for MYO16 Gene

  • Myosin XVI 2 3 5
  • Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adaptor 3 2 3
  • Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adapter 3 3 4
  • Protein Phosphatase 1, Regulatory Subunit 107 2 3
  • Unconventional Myosin-16 3 4
  • Myo16b 3 4
  • NYAP3 3 4
  • Unconventional Myosin-XVI 3
  • Myosin Heavy Chain Myr 8 3
  • MYO16 Variant Protein 3
  • PPP1R107 3
  • KIAA0865 4
  • MYAP3 3
  • MYR8 3

External Ids for MYO16 Gene

Previous GeneCards Identifiers for MYO16 Gene

  • GC13P108047
  • GC13P109248
  • GC13P089841
  • GC13P108596

Summaries for MYO16 Gene

Entrez Gene Summary for MYO16 Gene

  • This gene encodes an unconventional myosin protein. The encoded protein has been proposed to act as a serine/threonine phosphatase-1 targeting or regulatory subunit. Studies in a rat cell line suggest that this protein may regulate cell cycle progression. A variant within this gene may be associated with susceptibility to schizophrenia and elevated expression of this gene has been observed in the frontal cortex of human schizophrenia patients. [provided by RefSeq, Mar 2017]

GeneCards Summary for MYO16 Gene

MYO16 (Myosin XVI) is a Protein Coding gene. Diseases associated with MYO16 include Schizophrenia. GO annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is MYO9A.

UniProtKB/Swiss-Prot for MYO16 Gene

  • Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity).

Additional gene information for MYO16 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO16 Gene

Genomics for MYO16 Gene

Regulatory Elements for MYO16 Gene

Enhancers for MYO16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H109153 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.2 +662.4 662376 9 HDGF TBL1XR1 RB1 SIN3A BMI1 RAD21 BATF RFX5 SMARCC2 ZNF207 IRS2 MYO16-AS1 MYO16 LOC105370356
GH13H108914 1.7 FANTOM5 Ensembl ENCODE 4.6 +421.1 421142 4 ATF1 MLX ARID4B DMAP1 BRCA1 YY1 FOS ATF7 REST PPARG MYO16 GC13P108973 GC13M108717
GH13H109145 1.3 Ensembl ENCODE dbSUPER 5.5 +651.6 651645 4 CTCF JUN MAX SIN3A RAD21 RFX5 POLR2A SMC3 ZNF143 FOS IRS2 MYO16 LOC105370356 MYO16-AS2
GH13H108620 0.3 FANTOM5 14.5 +124.9 124874 0 MYO16 GC13M108703
GH13H109150 0.7 ENCODE dbSUPER 6.2 +656.0 656021 1 JUND JUN MYO16 LOC105370356 MYO16-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYO16 on UCSC Golden Path with GeneCards custom track

Genomic Location for MYO16 Gene

Chromosome:
13
Start:
108,495,729 bp from pter
End:
109,208,007 bp from pter
Size:
712,279 bases
Orientation:
Plus strand

Genomic View for MYO16 Gene

Genes around MYO16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO16 Gene

Proteins for MYO16 Gene

  • Protein details for MYO16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6X6-MYO16_HUMAN
    Recommended name:
    Unconventional myosin-XVI
    Protein Accession:
    Q9Y6X6
    Secondary Accessions:
    • A6H8Y0
    • A8MTX3
    • Q5VYX4
    • Q5VYX5
    • Q5VYX6
    • Q6ZS13
    • Q8N3C2
    • Q8N948

    Protein attributes for MYO16 Gene

    Size:
    1858 amino acids
    Molecular mass:
    206129 Da
    Quaternary structure:
    • Binds PPP1CA and/or PPP1CC. Binds F-actin in an ATP-sensitive manner. Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity). Interacts with KIRREL3 (PubMed:25902260).
    SequenceCaution:
    • Sequence=BAA74888.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC04608.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC87143.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MYO16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO16 Gene

Post-translational modifications for MYO16 Gene

  • Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYO16 Gene

No data available for DME Specific Peptides for MYO16 Gene

Domains & Families for MYO16 Gene

Suggested Antigen Peptide Sequences for MYO16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6X6

UniProtKB/Swiss-Prot:

MYO16_HUMAN :
  • In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Family:
  • In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
  • In the C-terminal section; belongs to the NYAP family.
genes like me logo Genes that share domains with MYO16: view

Function for MYO16 Gene

Molecular function for MYO16 Gene

UniProtKB/Swiss-Prot Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity).

Phenotypes From GWAS Catalog for MYO16 Gene

Gene Ontology (GO) - Molecular Function for MYO16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005524 ATP binding IEA --
GO:0032403 protein complex binding IEA --
GO:0051015 actin filament binding ISS 11588169
genes like me logo Genes that share ontologies with MYO16: view

Phenotypes for MYO16 Gene

genes like me logo Genes that share phenotypes with MYO16: view

Animal Model Products

CRISPR Products

miRNA for MYO16 Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MYO16
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYO16 Gene

Localization for MYO16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO16 Gene

Cytoplasm. Note=Found in puncta in soma and processes of astrocytes and dissociated cerebellar cells with the morphology of migrating granule cells. {ECO:0000250 UniProtKB:Q9ERC1}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYO16 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
plasma membrane 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MYO16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA 17029291
GO:0005737 cytoplasm ISS 11588169
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane ISS 11588169
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MYO16: view

Pathways & Interactions for MYO16 Gene

SuperPathways for MYO16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYO16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation ISS 17029291
GO:0014065 phosphatidylinositol 3-kinase signaling IEA --
GO:0021549 cerebellum development ISS 11588169
GO:0048812 neuron projection morphogenesis IEA --
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle ISS 17029291
genes like me logo Genes that share ontologies with MYO16: view

No data available for Pathways by source and SIGNOR curated interactions for MYO16 Gene

Drugs & Compounds for MYO16 Gene

No Compound Related Data Available

Transcripts for MYO16 Gene

Unigene Clusters for MYO16 Gene

Myosin XVI:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MYO16
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MYO16 Gene

No ASD Table

Relevant External Links for MYO16 Gene

GeneLoc Exon Structure for
MYO16
ECgene alternative splicing isoforms for
MYO16

Expression for MYO16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYO16 Gene

mRNA differential expression in normal tissues according to GTEx for MYO16 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x4.6).

Protein differential expression in normal tissues from HIPED for MYO16 Gene

This gene is overexpressed in Lung (25.8), Heart (18.2), Ovary (9.3), Islet of Langerhans (7.9), and Fetal Liver (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYO16 Gene



NURSA nuclear receptor signaling pathways regulating expression of MYO16 Gene:

MYO16

SOURCE GeneReport for Unigene cluster for MYO16 Gene:

Hs.656587

Evidence on tissue expression from TISSUES for MYO16 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with MYO16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYO16 Gene

Orthologs for MYO16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYO16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO16 33 34
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia MYO16 33 34
  • 85.57 (n)
mouse
(Mus musculus)
Mammalia Myo16 33 16 34
  • 77.72 (n)
oppossum
(Monodelphis domestica)
Mammalia MYO16 34
  • 77 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYO16 33 34
  • 75.42 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MYO16 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYO16 33 34
  • 73.04 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia myo16 33
  • 64.16 (n)
zebrafish
(Danio rerio)
Actinopterygii myo16 33 34
  • 61.14 (n)
Species where no ortholog for MYO16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO16 Gene

ENSEMBL:
Gene Tree for MYO16 (if available)
TreeFam:
Gene Tree for MYO16 (if available)

Paralogs for MYO16 Gene

Paralogs for MYO16 Gene

(7) SIMAP similar genes for MYO16 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MYO16: view

Variants for MYO16 Gene

Sequence variations from dbSNP and Humsavar for MYO16 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs193921058 Uncertain significance 109,120,425(+) TGATT(G/T)GTGCC reference, missense
rs1000000332 -- 108,604,465(+) AATCA(C/T)AGTGA intron-variant
rs1000000632 -- 108,826,547(+) TAAAA(A/G)CAAAA intron-variant
rs1000001477 -- 108,955,352(+) CATAT(A/T)CCAAA intron-variant
rs1000005809 -- 108,920,063(+) AGAAG(C/T)TTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYO16 Gene

Variant ID Type Subtype PubMed ID
dgv1038n106 CNV deletion 24896259
dgv3384n54 CNV loss 21841781
dgv55n73 CNV deletion 24416366
esv1038256 CNV insertion 17803354
esv1152422 CNV insertion 17803354
esv1656960 CNV deletion 17803354
esv1695062 CNV insertion 17803354
esv2367242 CNV deletion 18987734
esv23749 CNV gain 19812545
esv2395984 CNV deletion 18987734
esv2589356 CNV deletion 19546169
esv26162 CNV gain+loss 19812545
esv2632168 CNV deletion 19546169
esv2657985 CNV deletion 23128226
esv2747975 CNV deletion 23290073
esv2747977 CNV deletion 23290073
esv2747978 CNV deletion 23290073
esv2747979 CNV deletion 23290073
esv2747980 CNV deletion 23290073
esv2747981 CNV deletion 23290073
esv2747982 CNV deletion 23290073
esv28586 CNV loss 19812545
esv3303375 CNV mobile element insertion 20981092
esv3381 CNV loss 18987735
esv3385914 CNV insertion 20981092
esv3397426 CNV insertion 20981092
esv3551059 CNV deletion 23714750
esv3551062 CNV deletion 23714750
esv3580888 CNV loss 25503493
esv3580889 CNV loss 25503493
esv3580890 CNV loss 25503493
esv3633509 CNV loss 21293372
esv3633510 CNV loss 21293372
esv3633511 CNV loss 21293372
esv3633513 CNV loss 21293372
esv3633514 CNV loss 21293372
esv3633515 CNV loss 21293372
esv3633516 CNV loss 21293372
esv3633518 CNV loss 21293372
esv3633519 CNV loss 21293372
esv5193 CNV loss 18987735
esv9706 CNV loss 19470904
esv990061 CNV insertion 20482838
esv994778 CNV insertion 20482838
esv997483 CNV gain 20482838
esv998130 CNV deletion 20482838
nsv1037215 CNV gain 25217958
nsv1050169 CNV gain 25217958
nsv1069771 CNV deletion 25765185
nsv1133202 CNV tandem duplication 24896259
nsv1134349 CNV deletion 24896259
nsv1139838 CNV deletion 24896259
nsv1144698 CNV deletion 24896259
nsv1147448 CNV duplication 26484159
nsv1152714 CNV deletion 26484159
nsv1160148 CNV deletion 26073780
nsv1178 CNV insertion 18451855
nsv1179 CNV insertion 18451855
nsv473125 CNV novel sequence insertion 20440878
nsv474020 CNV novel sequence insertion 20440878
nsv477510 CNV novel sequence insertion 20440878
nsv479772 CNV novel sequence insertion 20440878
nsv481611 CNV novel sequence insertion 20440878
nsv509515 CNV insertion 20534489
nsv510366 OTHER sequence alteration 20534489
nsv512336 CNV loss 21212237
nsv525337 CNV loss 19592680
nsv563067 CNV loss 21841781
nsv563068 CNV loss 21841781
nsv563071 CNV gain 21841781
nsv64924 CNV deletion 16902084
nsv819031 CNV gain 19587683
nsv821014 CNV deletion 20802225
nsv826784 CNV loss 20364138
nsv826785 CNV gain+loss 20364138
nsv826787 CNV gain 20364138
nsv832717 CNV loss 17160897
nsv832718 CNV gain 17160897
nsv9105 CNV loss 18304495
nsv9106 CNV loss 18304495
nsv957457 CNV deletion 24416366

Variation tolerance for MYO16 Gene

Residual Variation Intolerance Score: 12.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.25; 97.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYO16 Gene

Human Gene Mutation Database (HGMD)
MYO16
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYO16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO16 Gene

Disorders for MYO16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYO16 Gene - From: GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search MYO16 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYO16

Genetic Association Database (GAD)
MYO16
Human Genome Epidemiology (HuGE) Navigator
MYO16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO16
genes like me logo Genes that share disorders with MYO16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYO16 Gene

Publications for MYO16 Gene

  1. Autism and Intellectual Disability-Associated KIRREL3 Interacts with Neuronal Proteins MAP1B and MYO16 with Potential Roles in Neurodevelopment. (PMID: 25902260) Liu YF … Srivastava AK (PloS one 2015) 3 4 60
  2. NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. (PMID: 21946561) Yokoyama K … Yamamoto T (The EMBO journal 2011) 2 3 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 45 60
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60

Products for MYO16 Gene

Sources for MYO16 Gene

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