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MYO15B Gene

pseudogene   GIFtS: 37
GCID: GC17P073586

Myosin XVB Pseudogene

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin XVB Pseudogene1 2
MYO15BP2 3
Myosin XVB2
KIAA17833
Myosin XVBP3
Unconventional Myosin-15B3

External Ids:    HGNC: 140831   Entrez Gene: 800222   Ensembl: ENSG000002667147   UniProtKB: Q96JP23   

Export aliases for MYO15B gene to outside databases

Previous GC identifers: GC17P073562 GC17P076610 GC17P074048 GC17P074182 GC17P074214 GC17P071096 GC17P069007


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYO15B Gene:
MYO15B (myosin XVB pseudogene) is a pseudogene. An important paralog of this gene is MYO1D.

UniProtKB/Swiss-Prot: MY15B_HUMAN, Q96JP2
Function: Unknown, due to the absence of a functional motor domain




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYO15B gene promoter:
         Max1   TBP   AML1a   MyoD   Lmo2   IRF-1   E47   AREB6   PPAR-gamma1   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MYO15B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYO15B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25

MYO15B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYO15B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P073586:  view genomic region     (about GC identifiers)

Start:
73,584,139 bp from pter      End:
73,622,929 bp from pter
Size:
38,791 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MYO15B

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MY15B_HUMAN, Q96JP2 (See protein sequence)
Recommended Name: Unconventional myosin-XVB  
Size: 1530 amino acids; 167118 Da
Caution: Was thought be the product of a pseudogene due to the substitution or deletion of many conserved amino
acids in the motor domain. However it has been observed with several high-quality proteotypic peptides in several
independent proteomic studies
Caution: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-15
(MYH15)
Sequence caution: Sequence=BAB47412.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for MYO15B:
2DLP (3D)    

Explore the universe of human proteins at neXtProt for MYO15B: NX_Q96JP2

Explore proteomics data for MYO15B at MOPED


See MYO15B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000463072   ENSP00000464561   ENSP00000463645   ENSP00000463464   ENSP00000464669  

MYO15B Human Recombinant Protein Products:

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Search eBioscience for ELISAs for MYO15B 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
MYOXV: Myosins / Myosin superfamily : Class XV

Selected InterPro protein domains (see all 6):
 IPR001452 SH3_domain
 IPR011511 SH3_2
 IPR027417 P-loop_NTPase
 IPR000857 MyTH4_dom
 IPR000048 IQ_motif_EF-hand-BS

Graphical View of Domain Structure for InterPro Entry Q96JP2

ProtoNet protein and cluster: Q96JP2

UniProtKB/Swiss-Prot: MY15B_HUMAN, Q96JP2
Similarity: Contains 1 IQ domain
Similarity: Contains 1 myosin head-like domain
Similarity: Contains 1 MyTH4 domain
Similarity: Contains 1 SH3 domain


Find genes that share domains with MYO15B           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: MY15B_HUMAN, Q96JP2
Function: Unknown, due to the absence of a functional motor domain

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ----
GO:0003774motor activity ----
GO:0005515protein binding ----
GO:0005524ATP binding ----
     
Find genes that share ontologies with MYO15B           About GenesLikeMe


Phenotypes:
     1 MGI phenotypic allele for Myo15b (no phenotypes)

Find genes that share phenotypes with MYO15B           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYO15B
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYO15B

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYO15B
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYO15B

miRNA
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Predesigned siRNA for gene silencing in human, mouse, rat MYO15B

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
MY15B_HUMAN, Q96JP2: Cytoplasm (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
cytoskeleton2
extracellular1
golgi apparatus1
mitochondrion1
nucleus1
peroxisome1
plasma membrane1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ----
GO:0005737cytoplasm ----
GO:0005856cytoskeleton ----
GO:0016459myosin complex ----

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYO15B
Interactions:

    Search GeneGlobe Interaction Network for MYO15B

Selected Interacting proteins for MYO15B (Q96JP22, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 780)
InteractantInteraction Details
GeneCardExternal ID(s)
GFAPP141362, 3MINT-67875 I2D: score=1 
NADSYN1Q6IA692, 3MINT-67535 I2D: score=1 
RAD54BQ9Y6202, 3MINT-67305 I2D: score=1 
SSSCA1O602322, 3MINT-66463 I2D: score=1 
TRIM29Q141342, 3MINT-68382 I2D: score=1 
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008150biological_process ----

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MYO15B (MY15B)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MYO15B gene: 
NM_001080847.1  

Unigene Cluster for MYO15B:

Myosin XVB pseudogene
Hs.390817  [show with all ESTs]
Unigene Representative Sequence: NR_003587
Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32):
ENST00000584516(uc002joo.1) ENST00000578382(uc002jom.1 uc002jon.1 uc010dgh.3 uc010dgj.1)
ENST00000578564 ENST00000582561 ENST00000581612 ENST00000581866 ENST00000580701
ENST00000584762 ENST00000584323(uc002joq.3) ENST00000583560 ENST00000582012
ENST00000580724 ENST00000578462 ENST00000584723 ENST00000580176 ENST00000578005
ENST00000577342 ENST00000578960
miRNA
Products:
     
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Search for qRT-PCR Assays for microRNAs that regulate MYO15B
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for MYO15B
Predesigned siRNA for gene silencing in human, mouse, rat MYO15B
Clone
Products:
     
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for MYO15B
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYO15B
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MYO15B
Primer
Products:
    
Browse OriGene qPCR
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MYO15B
  QuantiTect SYBR Green Assays in human, mouse, rat MYO15B
  QuantiFast Probe-based Assays in human, mouse, rat MYO15B

Additional mRNA sequence: 

AB058686.1 AF418286.1 AF418287.1 AF418288.1 AF418289.1 AF418290.1 AF418291.1 AF418292.1 
AF418293.1 AK021565.1 AK025259.1 AK026339.1 AK074680.1 AK096869.1 AK097896.1 AK126458.1 
AL713730.1 BC027875.1 BC033247.1 BC128044.1 NR_003587.2 

Selected DOTS entries (see all 25):

DT.91698295  DT.95219972  DT.95128851  DT.100839076  DT.97762728  DT.92016722  DT.446323  DT.100788332 
DT.91877344  DT.120933939  DT.91938197  DT.120933718  DT.120933861  DT.305713  DT.91677389  DT.95219967 
DT.95219969  DT.97786836  DT.120933767  DT.91824797  DT.91839463  DT.95248710  DT.75101229  DT.91988960 

Selected AceView cDNA sequences (see all 186):

BX504202 BF476683 BQ709421 AI537992 AA292802 AW339946 CB155174 BM666647 
BC027875 BM791149 BM996595 AI344135 BU615924 AL713730 BM977966 BU150940 
AI283270 CA412202 AI825877 AI569620 BI766913 AB058686 BF899041 CD244282 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MYO15B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGAGAAACAG
MYO15B Expression
About this image


MYO15B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Kidney (Urinary System)    fully expand to see all 8 entries
         Loop of Henle Cells Loop of Henle
         Metanephros
 
 Epithelial Cells
         Loop of Henle Cells Loop of Henle
 
 Intermediate Mesoderm (Gastrulation Derivatives)
         Mesonephros
 
 Bone (Muscoskeletal System)
         Chondrocyte-like cells
 
 Cartilage (Muscoskeletal System)
         Chondrocyte-like cells
MYO15B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MYO15B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.390817

UniProtKB/Swiss-Prot: MY15B_HUMAN, Q96JP2
Tissue specificity: Detected in brain, stomach and kidney

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO15B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for MYO15B gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Myo15b5 myosin XVB   --   11 (80.91 cM) 115861612 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
5(a)
many ↔ many
GL344263.1(38260-69855)
fruit fly
(Drosophila melanogaster)
Insecta d6
dachs
4(a)
1 → many
2L(8466830-8488671)
worm
(Caenorhabditis elegans)
Secernentea hum-46
Protein HUM-4, isoform a
2(a)
1 → many
X(11420471-11433524) WBGene00002037


ENSEMBL Gene Tree for MYO15B (if available)
TreeFam Gene Tree for MYO15B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MYO15B gene
MYO1D2  MYO15A2  MYO1C2  MYO1A2  MYO1F2  MYO1G2  MYO1B2  MYO1E2  
MYO1H2  MYO192  
16 SIMAP similar genes for MYO15B using alignment to 7 protein entries:     MY15B_HUMAN (see all proteins):
DKFZp667C0210    NUSAP1    ZNF738    IPO7    COX7A2    MTA3
MYO1D    MYO1G    MYO1C    MYO1B    MYH2    MYO5C
MYO9A    MYO1A    MYO15A    MYO10

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MYO15B (see all 986)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1472900361,2
--73582314(+) TAAATC/TGGCAC 1 -- us2k10--------
rs13780281,2
C--73582457(-) CTCATC/TTTTTG 1 -- us2k15Minor allele frequency- T:0.04NA WA EA 362
rs18994111,2
C,F--73582462(+) GATGAG/AAGGAA 1 -- us2k14Minor allele frequency- A:0.13WA CSA NA 242
rs1929960161,2
--73582467(+) GAGGAA/TGGAAG 1 -- us2k10--------
rs348618461,2
C--73582481(+) TTTTT-/TAAGAG 1 -- us2k11Minor allele frequency- T:0.00NA 2
rs1398921431,2
C--73582544(+) GTAGGC/GTGGAA 1 -- us2k10--------
rs1492592731,2
--73582547(+) GGGTGA/GAACAA 1 -- us2k10--------
rs1444947831,2
--73582589(+) TTCAAG/TCGATT 1 -- us2k10--------
rs1484378981,2
--73582630(+) TTACAA/GGCATG 1 -- us2k10--------
rs1830023771,2
C--73582707(+) GATCTC/TGAACT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for MYO15B (73584139 - 73622929 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for MYO15B (see all 19):    About this table    
Variant IDTypeSubtypePubMed ID
dgv3263n71CNV Loss21882294
nsv516133CNV Loss19592680
nsv908790CNV Loss21882294
dgv3259n71CNV Loss21882294
dgv3262n71CNV Loss21882294
dgv3260n71CNV Loss21882294
nsv833543CNV Loss17160897
nsv908794CNV Loss21882294
nsv470603CNV Loss18288195
nsv908777CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing MYO15B
DNA2.0 Custom Variant and Variant Library Synthesis for MYO15B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MYO15B gene integrated from 10 sources:
(articles sorted by number of sources associating them with MYO15B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A millennial myosin census. (PubMed id 11294886)1, 2, 3 Berg J.S.... Cheney R.E. (Mol. Biol. Cell 2001)
  2. Human myosin XVBP is a transcribed pseudogene. (PubMed id 11964073)1, 2, 9 Boger E.T.... Friedman T.B. (J. Muscle Res. Cell Motil. 2001)
  3. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
  4. Exploration of human ORFeome: high-throughput preparation of ORF clones and efficient characterization of their protein products. (PubMed id 18316326)1 Nagase T....Ohara O. (DNA Res. 2008)
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  8. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 80022 HGNC: 14083 AceView: MYO15B Ensembl:ENSG00000266714 euGenes: HUgn80022
ECgene: MYO15B H-InvDB: MYO15B

(According to HUGE)
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HUGE: KIAA1783

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MYO15B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MYO15B gene:
Search GeneIP for patents involving MYO15B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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