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Aliases for MYO15B Gene

Aliases for MYO15B Gene

  • Myosin XVB 2 3 5
  • Myosin XVB Pseudogene 2 3
  • MYO15BP 3 4
  • Unconventional Myosin XVBP Pseudogene 3
  • Unconventional Myosin-15B 4
  • Myosin XVBP 4
  • KIAA1783 4

External Ids for MYO15B Gene

Previous GeneCards Identifiers for MYO15B Gene

  • GC17P073562
  • GC17P076610
  • GC17P074048
  • GC17P074182
  • GC17P074214
  • GC17P071096
  • GC17P069007
  • GC17P073586

Summaries for MYO15B Gene

GeneCards Summary for MYO15B Gene

MYO15B (Myosin XVB) is a Protein Coding gene. An important paralog of this gene is MYO7B.

UniProtKB/Swiss-Prot for MYO15B Gene

  • Unknown, due to the absence of a functional motor domain.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO15B Gene

Genomics for MYO15B Gene

Regulatory Elements for MYO15B Gene

Enhancers for MYO15B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MYO15B on UCSC Golden Path with GeneCards custom track

Promoters for MYO15B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MYO15B on UCSC Golden Path with GeneCards custom track

Genomic Location for MYO15B Gene

Chromosome:
17
Start:
75,588,058 bp from pter
End:
75,626,849 bp from pter
Size:
38,792 bases
Orientation:
Plus strand

Genomic View for MYO15B Gene

Genes around MYO15B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO15B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO15B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO15B Gene

Proteins for MYO15B Gene

  • Protein details for MYO15B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JP2-MY15B_HUMAN
    Recommended name:
    Unconventional myosin-XVB
    Protein Accession:
    Q96JP2

    Protein attributes for MYO15B Gene

    Size:
    1530 amino acids
    Molecular mass:
    167118 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47412.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MYO15B Gene

neXtProt entry for MYO15B Gene

Proteomics data for MYO15B Gene at MOPED

Post-translational modifications for MYO15B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MYO15B Gene

Domains & Families for MYO15B Gene

Gene Families for MYO15B Gene

Protein Domains for MYO15B Gene

Suggested Antigen Peptide Sequences for MYO15B Gene

Graphical View of Domain Structure for InterPro Entry

Q96JP2

UniProtKB/Swiss-Prot:

MY15B_HUMAN :
  • Contains 1 IQ domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • Contains 1 IQ domain.
  • Contains 1 myosin motor domain.
  • Contains 1 MyTH4 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO15B: view

Function for MYO15B Gene

Molecular function for MYO15B Gene

UniProtKB/Swiss-Prot Function:
Unknown, due to the absence of a functional motor domain.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYO15B Gene

Localization for MYO15B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO15B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO15B Gene COMPARTMENTS Subcellular localization image for MYO15B gene
Compartment Confidence
cytosol 3
cytoskeleton 2
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MYO15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005903 brush border IEA --
genes like me logo Genes that share ontologies with MYO15B: view

Pathways & Interactions for MYO15B Gene

SuperPathways for MYO15B Gene

No Data Available

Interacting Proteins for MYO15B Gene

Gene Ontology (GO) - Biological Process for MYO15B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MYO15B Gene

Drugs & Compounds for MYO15B Gene

No Compound Related Data Available

Transcripts for MYO15B Gene

Unigene Clusters for MYO15B Gene

Myosin XVB pseudogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYO15B Gene

No ASD Table

Relevant External Links for MYO15B Gene

GeneLoc Exon Structure for
MYO15B
ECgene alternative splicing isoforms for
MYO15B

Expression for MYO15B Gene

mRNA expression in normal human tissues for MYO15B Gene

Protein differential expression in normal tissues from HIPED for MYO15B Gene

This gene is overexpressed in Fetal gut (58.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MYO15B Gene



SOURCE GeneReport for Unigene cluster for MYO15B Gene Hs.390817

mRNA Expression by UniProt/SwissProt for MYO15B Gene

Q96JP2-MY15B_HUMAN
Tissue specificity: Detected in brain, stomach and kidney.
genes like me logo Genes that share expression patterns with MYO15B: view

Protein tissue co-expression partners for MYO15B Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MYO15B Gene

Orthologs for MYO15B Gene

This gene was present in the common ancestor of animals.

Orthologs for MYO15B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MYO15B 36
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYO15B 36
OneToOne
mouse
(Mus musculus)
Mammalia Myo15b 36
  • 8 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYO15B 36
  • 7 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 5 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta d 36
  • 4 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hum-4 36
  • 2 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2003 36
  • 4 (a)
OneToMany
Species with no ortholog for MYO15B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MYO15B Gene

ENSEMBL:
Gene Tree for MYO15B (if available)
TreeFam:
Gene Tree for MYO15B (if available)

Paralogs for MYO15B Gene

Paralogs for MYO15B Gene

genes like me logo Genes that share paralogs with MYO15B: view

Variants for MYO15B Gene

Sequence variations from dbSNP and Humsavar for MYO15B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10808 -- 75,620,773(+) TGCCC(C/G)CTCCT intron-variant
rs10814 -- 75,620,840(+) GCTGG(A/G)TGCTG intron-variant
rs11470 -- 75,620,784(+) GATGG(A/C)TCGCC intron-variant
rs936054 -- 75,605,674(-) ATGCA(C/T)CTCTC intron-variant
rs936056 -- 75,591,703(-) CACTC(C/T)CGGTT nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MYO15B Gene

Variant ID Type Subtype PubMed ID
nsv516133 CNV Loss 19592680
dgv3256n71 CNV Loss 21882294
nsv470603 CNV Loss 18288195
dgv3257n71 CNV Loss 21882294
nsv833543 CNV Loss 17160897
nsv908777 CNV Loss 21882294
dgv3259n71 CNV Loss 21882294
dgv3260n71 CNV Loss 21882294
dgv3261n71 CNV Loss 21882294
dgv3262n71 CNV Loss 21882294
dgv3263n71 CNV Loss 21882294
nsv908790 CNV Loss 21882294
nsv908794 CNV Loss 21882294
dgv3264n71 CNV Loss 21882294
dgv373n27 CNV Gain 19166990
nsv470604 CNV Gain 18288195
dgv3265n71 CNV Loss 21882294
nsv833544 CNV Loss 17160897
nsv908800 CNV Loss 21882294

Variation tolerance for MYO15B Gene

Gene Damage Index Score: 12.73; 94.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MYO15B Gene

Disorders for MYO15B Gene

Relevant External Links for MYO15B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO15B

No disorders were found for MYO15B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYO15B Gene

Publications for MYO15B Gene

  1. A millennial myosin census. (PMID: 11294886) Berg J.S. … Cheney R.E. (Mol. Biol. Cell 2001) 2 3 4 67
  2. Human myosin XVBP is a transcribed pseudogene. (PMID: 11964073) Boger E.T. … Friedman T.B. (J. Muscle Res. Cell Motil. 2001) 3 23
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for MYO15B Gene

Sources for MYO15B Gene

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