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Aliases for MYO15B Gene

Aliases for MYO15B Gene

  • Myosin XVB 2 3 5
  • Myosin XVB Pseudogene 2 3
  • MYO15BP 3 4
  • Unconventional Myosin XVBP Pseudogene 3
  • Unconventional Myosin-15B 4
  • Myosin XVBP 4
  • KIAA1783 4

External Ids for MYO15B Gene

Previous GeneCards Identifiers for MYO15B Gene

  • GC17P073562
  • GC17P076610
  • GC17P074048
  • GC17P074182
  • GC17P074214
  • GC17P071096
  • GC17P069007
  • GC17P073586

Summaries for MYO15B Gene

GeneCards Summary for MYO15B Gene

MYO15B (Myosin XVB) is a Protein Coding gene. An important paralog of this gene is MYO15A.

UniProtKB/Swiss-Prot for MYO15B Gene

  • Unknown, due to the absence of a functional motor domain.

Additional gene information for MYO15B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO15B Gene

Genomics for MYO15B Gene

Regulatory Elements for MYO15B Gene

Enhancers for MYO15B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H075575 1.4 Ensembl ENCODE dbSUPER 35.5 -10.5 -10514 4 PKNOX1 MLX ARID4B SLC30A9 SP3 SP5 PPARG KAT8 NFIL3 SSRP1 MYO15B SRP68 NUP85 UNK NAT9 EXOC7 ENSG00000267342 MRPL38 LLGL2 MRPS7
GH17H075632 1.9 FANTOM5 Ensembl ENCODE dbSUPER 24.2 +47.2 47244 5 HDGF PKNOX1 MLX ARID4B SIN3A ZNF2 GLIS2 ZNF207 ZNF143 ATF7 MYO15B RECQL5 NT5C NUP85 UNK SMIM5 ENSG00000266980 SAP30BP TRIM65 GGA3
GH17H075587 1 ENCODE 36.9 +0.5 490 2 HDGF ARNT ARID4B SIN3A ZBTB7B ETS1 ZNF121 ZNF766 GLIS2 ELK1 MYO15B ENSG00000267342 NAT9 UNK EXOC7 NUP85 ENSG00000267543 ENSG00000267546 RN7SL573P SAP30BP
GH17H075580 0.8 Ensembl ENCODE 36.5 -6.8 -6768 1 SP1 NFYB ZNF207 NFYC ZNF600 ZBTB33 FOS MYO15B GC17M075573
GH17H075530 1.2 Ensembl ENCODE dbSUPER 19.7 -56.4 -56378 2 TBP SCRT1 HDGF USF2 ZIC2 OSR2 MTA3 POLR2A ZBTB33 CHD2 TMEM94 MYO15B LLGL2 TSEN54 GC17P075560
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYO15B on UCSC Golden Path with GeneCards custom track

Promoters for MYO15B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098410 742 2001 HDGF ARNT ARID4B SIN3A ZBTB7B ETS1 ZNF121 ZNF766 GLIS2 ELK1

Genomic Location for MYO15B Gene

Chromosome:
17
Start:
75,588,058 bp from pter
End:
75,626,849 bp from pter
Size:
38,792 bases
Orientation:
Plus strand

Genomic View for MYO15B Gene

Genes around MYO15B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO15B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO15B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO15B Gene

Proteins for MYO15B Gene

  • Protein details for MYO15B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JP2-MY15B_HUMAN
    Recommended name:
    Unconventional myosin-XVB
    Protein Accession:
    Q96JP2

    Protein attributes for MYO15B Gene

    Size:
    1530 amino acids
    Molecular mass:
    167118 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47412.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MYO15B Gene

neXtProt entry for MYO15B Gene

Post-translational modifications for MYO15B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MYO15B Gene

Domains & Families for MYO15B Gene

Gene Families for MYO15B Gene

Suggested Antigen Peptide Sequences for MYO15B Gene

Graphical View of Domain Structure for InterPro Entry

Q96JP2

UniProtKB/Swiss-Prot:

MY15B_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO15B: view

Function for MYO15B Gene

Molecular function for MYO15B Gene

UniProtKB/Swiss-Prot Function:
Unknown, due to the absence of a functional motor domain.

Phenotypes From GWAS Catalog for MYO15B Gene

Gene Ontology (GO) - Molecular Function for MYO15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYO15B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MYO15B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYO15B Gene

Localization for MYO15B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO15B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYO15B gene
Compartment Confidence
cytosol 3
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MYO15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IEA --
GO:0005903 brush border IEA --
GO:0016459 myosin complex IEA --
genes like me logo Genes that share ontologies with MYO15B: view

Pathways & Interactions for MYO15B Gene

SuperPathways for MYO15B Gene

No Data Available

Interacting Proteins for MYO15B Gene

Gene Ontology (GO) - Biological Process for MYO15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007605 sensory perception of sound IEA --
genes like me logo Genes that share ontologies with MYO15B: view

No data available for Pathways by source and SIGNOR curated interactions for MYO15B Gene

Drugs & Compounds for MYO15B Gene

No Compound Related Data Available

Transcripts for MYO15B Gene

Unigene Clusters for MYO15B Gene

Myosin XVB pseudogene:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MYO15B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MYO15B Gene

No ASD Table

Relevant External Links for MYO15B Gene

GeneLoc Exon Structure for
MYO15B
ECgene alternative splicing isoforms for
MYO15B

Expression for MYO15B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYO15B Gene

Protein differential expression in normal tissues from HIPED for MYO15B Gene

This gene is overexpressed in Fetal gut (58.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYO15B Gene



Protein tissue co-expression partners for MYO15B Gene

NURSA nuclear receptor signaling pathways regulating expression of MYO15B Gene:

MYO15B

SOURCE GeneReport for Unigene cluster for MYO15B Gene:

Hs.390817

mRNA Expression by UniProt/SwissProt for MYO15B Gene:

Q96JP2-MY15B_HUMAN
Tissue specificity: Detected in brain, stomach and kidney.

Evidence on tissue expression from TISSUES for MYO15B Gene

  • Nervous system(4.5)
  • Kidney(4.1)
  • Stomach(4)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with MYO15B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYO15B Gene

Orthologs for MYO15B Gene

This gene was present in the common ancestor of animals.

Orthologs for MYO15B Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Myo15b 34
  • 8 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYO15B 34
  • 7 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYO15B 34
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYO15B 34
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 5 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta d 34
  • 4 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hum-4 34
  • 2 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2003 34
  • 4 (a)
OneToMany
Species where no ortholog for MYO15B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MYO15B Gene

ENSEMBL:
Gene Tree for MYO15B (if available)
TreeFam:
Gene Tree for MYO15B (if available)

Paralogs for MYO15B Gene

Paralogs for MYO15B Gene

genes like me logo Genes that share paralogs with MYO15B: view

Variants for MYO15B Gene

Sequence variations from dbSNP and Humsavar for MYO15B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000125398 -- 75,603,966(+) GGCTG(A/G)TGGCT intron-variant, upstream-variant-2KB
rs1000126605 -- 75,602,745(+) GCCGA(A/G)GGCTG intron-variant
rs1000285813 -- 75,597,416(+) CTATT(A/C)ATTCA intron-variant
rs1000355611 -- 75,626,120(+) AGCCT(A/G)CAGCG nc-transcript-variant, reference, synonymous-codon
rs1000436977 -- 75,592,485(+) ACTCC(A/G)TAGAG intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MYO15B Gene

Variant ID Type Subtype PubMed ID
dgv373n27 CNV gain 19166990
nsv470603 CNV loss 18288195
nsv470604 CNV gain 18288195
nsv516133 CNV loss 19592680
nsv576027 CNV gain 21841781
nsv576030 CNV gain 21841781
nsv576031 CNV loss 21841781
nsv576032 CNV gain 21841781
nsv576033 CNV loss 21841781
nsv833543 CNV loss 17160897
nsv833544 CNV loss 17160897

Variation tolerance for MYO15B Gene

Gene Damage Index Score: 12.73; 94.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYO15B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYO15B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO15B Gene

Disorders for MYO15B Gene

Relevant External Links for MYO15B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO15B

No disorders were found for MYO15B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYO15B Gene

Publications for MYO15B Gene

  1. A millennial myosin census. (PMID: 11294886) Berg JS … Cheney RE (Molecular biology of the cell 2001) 2 3 4 60
  2. Human myosin XVBP is a transcribed pseudogene. (PMID: 11964073) Boger ET … Friedman TB (Journal of muscle research and cell motility 2001) 3 4 22 60
  3. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron ML … Lange BM (Nature communications 2013) 3 60

Products for MYO15B Gene

Sources for MYO15B Gene

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