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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYO15B Gene

pseudogene   GIFtS: 38
GCID: GC17P073586

Myosin XVB Pseudogene

  Search for MYO15B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 5

Aliases
Myosin XVB Pseudogene1 2
MYO15BP2 3
Myosin XVB2
KIAA17833
Myosin XVBP3
Unconventional Myosin-15B3

External Ids:    HGNC: 140831   Entrez Gene: 800222   Ensembl: ENSG000002667147   UniProtKB: Q96JP23   
ORGUL members:    fRNAdb10:FR041498      
NCBI13:XR_000222    
NONCODE14:n406154      
RNAdb15:LIT3315    

Export aliases for MYO15B gene to outside databases

Previous GC identifers: GC17P073562 GC17P076610 GC17P074048 GC17P074182 GC17P074214 GC17P071096 GC17P069007


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MYO15B Gene: 
MYO15B (myosin XVB pseudogene) is a pseudogene, and is affiliated with the lncRNA class.

UniProtKB/Swiss-Prot: MY15B_HUMAN, Q96JP2
Function: Unknown, due to the absence of a functional motor domain



fRNAdb sequence ontology for MYO15B:
mature_transcript - A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYO15B gene promoter:
         Max1   TBP   AML1a   MyoD   Lmo2   IRF-1   E47   AREB6   PPAR-gamma1   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MYO15B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYO15B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25

MYO15B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYO15B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P073586:  view genomic region     (about GC identifiers)

Start:
73,584,139 bp from pter      End:
73,622,929 bp from pter
Size:
38,791 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MYO15B

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MY15B_HUMAN, Q96JP2 (See protein sequence)
Recommended Name: Unconventional myosin-XVB  
Size: 1530 amino acids; 167118 Da
Subcellular location: Cytoplasm (Potential)
Caution: Was thought be the product of a pseudogene due to the substitution or deletion of many conserved
amino-acids in the motor domain. However it has been observed with several high-quality proteotypic peptides in
several independent proteomic studies
Caution: Represents a unconventional myosin. This protein should not be confused with the conventional myosin-15
(MYH15)
Sequence caution: Sequence=BAB47412.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for MYO15B:
2DLP (3D)    

Explore the universe of human proteins at neXtProt for MYO15B: NX_Q96JP2

Explore proteomics data for MYO15B at MOPED 

MYO15B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

MYO15B Protein Expression

ENSEMBL proteins: 
 ENSP00000463072   ENSP00000464561   ENSP00000463645   ENSP00000463464   ENSP00000464669  

Human Recombinant Protein Products for MYO15B: 
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Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ----
GO:0005737cytoplasm ----
GO:0005856cytoskeleton ----
GO:0016459myosin complex ----

MYO15B for ontologies           About GeneDecksing



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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
MYOXV: Myosins / Myosin superfamily : Class XV

5/6 InterPro protein domains (see all 6):
 IPR001452 SH3_domain
 IPR011511 SH3_2
 IPR027417 P-loop_NTPase
 IPR000857 MyTH4_dom
 IPR000048 IQ_motif_EF-hand-BS

Graphical View of Domain Structure for InterPro Entry Q96JP2

ProtoNet protein and cluster: Q96JP2

UniProtKB/Swiss-Prot: MY15B_HUMAN, Q96JP2
Similarity: Contains 1 IQ domain
Similarity: Contains 1 myosin head-like domain
Similarity: Contains 1 MyTH4 domain
Similarity: Contains 1 SH3 domain


MYO15B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: MY15B_HUMAN, Q96JP2
Function: Unknown, due to the absence of a functional motor domain

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ----
GO:0003774motor activity ----
GO:0005515protein binding ----
GO:0005524ATP binding ----
     
MYO15B for ontologies           About GeneDecksing


Animal Models:
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miRNA
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYO15B

5/781 Interacting proteins for MYO15B (Q96JP22, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 781)
InteractantInteraction Details
GeneCardExternal ID(s)
GFAPP141362, 3MINT-67875 I2D: score=1 
NADSYN1Q6IA692, 3MINT-67535 I2D: score=1 
RAD54BQ9Y6202, 3MINT-67305 I2D: score=1 
SSSCA1O602322, 3MINT-66463 I2D: score=1 
TRIM29Q141342, 3MINT-68382 I2D: score=1 
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008150biological_process ----

MYO15B for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MYO15B (MY15B)

Search CenterWatch for drugs/clinical trials and news about MYO15B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MYO15B gene: 
NM_001080847.1  

Unigene Cluster for MYO15B:

Myosin XVB pseudogene
Hs.390817  [show with all ESTs]
Unigene Representative Sequence: NR_003587
18/32 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32):
ENST00000584516(uc002joo.1) ENST00000578382(uc002jom.1 uc002jon.1 uc010dgh.3 uc010dgj.1)
ENST00000578564 ENST00000582561 ENST00000581612 ENST00000581866 ENST00000580701
ENST00000584762 ENST00000584323(uc002joq.3) ENST00000583560 ENST00000582012
ENST00000580724 ENST00000578462 ENST00000584723 ENST00000580176 ENST00000578005
ENST00000577342 ENST00000578960
miRNA
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Inhib. RNA
Products:
     
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Products:
     
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Additional mRNA sequence: 

AB058686.1 AF418286.1 AF418287.1 AF418288.1 AF418289.1 AF418290.1 AF418291.1 AF418292.1 
AF418293.1 AK021565.1 AK025259.1 AK026339.1 AK074680.1 AK096869.1 AK097896.1 AK126458.1 
AL713730.1 BC027875.1 BC033247.1 BC128044.1 NR_003587.2 

24/25 DOTS entries (see all 25):

DT.91698295  DT.95219972  DT.95128851  DT.100839076  DT.97762728  DT.92016722  DT.446323  DT.100788332 
DT.91877344  DT.120933939  DT.91938197  DT.120933718  DT.120933861  DT.305713  DT.91677389  DT.95219967 
DT.95219969  DT.97786836  DT.120933767  DT.91824797  DT.91839463  DT.95248710  DT.75101229  DT.91988960 

24/186 AceView cDNA sequences (see all 186):

BM666647 BU150940 BQ709421 CA412202 AV649878 BM977966 BF476683 CD244282 
BI766913 BE501985 BU615924 AI344135 AI283270 AB058686 AA292802 AI569620 
BM791149 AL713730 AI825877 BX504202 BF899041 AI537992 BM996595 CB155174 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MYO15B expression in normal human tissues (normalized intensities)      MYO15B embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGAGAAACAG
MYO15B Expression
About this image


MYO15B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/8 selected tissues (see all 8) fully expand
 
 Kidney (Urinary System)    fully expand to see all 10 entries
         Loop of Henle Cells Loop of Henle
         Proximal Tubule
         visceral organ/metanephros/renal medulla   
 
 Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
         visceral organ   
 
 Colon (Gastrointestinal Tract)
         colonic mucosal (ibs)   
 
 Heart (Cardiovascular System)
         heart muscle ; myocytes   
 
 Intestine (Gastrointestinal Tract)
         small intestine   

See MYO15B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MYO15B

SOURCE GeneReport for Unigene cluster: Hs.390817

UniProtKB/Swiss-Prot: MY15B_HUMAN, Q96JP2
Tissue specificity: Detected in brain, stomach and kidney

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYO15B gene from 6/12 species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Myo15b5 myosin XVB   --   11 (80.91 cM) 115861612 
chicken
(Gallus gallus)
Aves MYO196
Uncharacterized protein
4(a)
possible ortholog
19(8126102-8142183)
lizard
(Anolis carolinensis)
Reptilia MYO196
myosin XIX
6(a)
possible ortholog
GL344386.1(1643-31217)
zebrafish
(Danio rerio)
Actinopterygii MYO19 (1 of 2)6
MYO19 (2 of 2)6
myosin XIX

13(a)
possible ortholog
possible ortholog
5(3985485-3990678)
5(3960643-3978914)
fruit fly
(Drosophila melanogaster)
Insecta d6
dachs
3(a)
possible ortholog
2L(8466830-8488671)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO56
One of two type I myosins; contains proline-rich t...
4(a)
1 → many
XIII(486587-490246)


ENSEMBL Gene Tree for MYO15B (if available)
TreeFam Gene Tree for MYO15B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MYO15B gene
17 SIMAP similar genes for MYO15B using alignment to 8 protein entries:     MY15B_HUMAN (see all proteins):
DKFZp667C0210    NUSAP1    ZNF738    IPO7    COX7A2    MTA3
DKFZp686N18198    MYO1D    MYO1G    MYO1C    MYO1B    MYH2
MYO5C    MYO9A    MYO15A    MYO1A    MYO10

MYO15B for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/986 SNPs in MYO15B are shown (see all 986)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1472900361,2
--73582314(+) TAAATC/TGGCAC 1 -- us2k10--------
rs13780281,2
C--73582457(-) CTCATC/TTTTTG 1 -- us2k15Minor allele frequency- T:0.04NA WA EA 362
rs18994111,2
C,F--73582462(+) GATGAG/AAGGAA 1 -- us2k14Minor allele frequency- A:0.13WA CSA NA 242
rs1929960161,2
--73582467(+) GAGGAA/TGGAAG 1 -- us2k10--------
rs348618461,2
C--73582481(+) TTTTT-/TAAGAG 1 -- us2k11Minor allele frequency- T:0.00NA 2
rs1398921431,2
C--73582544(+) GTAGGC/GTGGAA 1 -- us2k10--------
rs1492592731,2
--73582547(+) GGGTGA/GAACAA 1 -- us2k10--------
rs1444947831,2
--73582589(+) TTCAAG/TCGATT 1 -- us2k10--------
rs1484378981,2
--73582630(+) TTACAA/GGCATG 1 -- us2k10--------
rs1830023771,2
C--73582707(+) GATCTC/TGAACT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for MYO15B (73584139 - 73622929 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/19 variations for MYO15B (see all 19):    About this table     
Variant IDTypeSubtypePubMed ID
dgv3263n71CNV Loss21882294
nsv516133CNV Loss19592680
nsv908790CNV Loss21882294
dgv3259n71CNV Loss21882294
dgv3262n71CNV Loss21882294
dgv3260n71CNV Loss21882294
nsv833543CNV Loss17160897
nsv908794CNV Loss21882294
nsv470603CNV Loss18288195
nsv908777CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MYO15B gene integrated from 9 sources:
(articles sorted by number of sources associating them with MYO15B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A millennial myosin census. (PubMed id 11294886)1, 2, 3 Berg J.S.... Cheney R.E. (2001)
  2. Human myosin XVBP is a transcribed pseudogene. (PubMed id 11964073)1, 2, 9 Boger E.T.... Friedman T.B. (2001)
  3. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
  4. Exploration of human ORFeome: high-throughput prepara tion of ORF clones and efficient characterization of their protein products. (PubMed id 18316326)1 Nagase T....Ohara O. (2008)
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  8. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)
  9. (PubMed id 15608161)10 

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 80022 HGNC: 14083 AceView: MYO15B Ensembl:ENSG00000266714 euGenes: HUgn80022
ECgene: MYO15B H-InvDB: MYO15B

(According to HUGE)
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HUGE: KIAA1783

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MYO15B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MYO15B gene:
Search GeneIP for patents involving MYO15B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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