MYO15B Gene
pseudogene GIFtS : 40
GCID: GC17 P073586
myosin XVB pseudogene
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Aliasesfor MYO15B gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section This gene clusters with an RNA geneSubcategory (RNA class): lncRNAQuality score for the ORGUL clustered with this gene is 5 Aliases Myosin XVB Pseudogene 1 2 MYO15BP1 2 3 Myosin XVB2 KIAA17833 Myosin XVBP3 Unconventional Myosin-15B3
External Ids: HGNC: 14083 1 Entrez Gene: 80022 2 Ensembl: ENSG00000188126 7 UniProtKB: Q96JP2 3 Export aliases for MYO15B gene to outside databases Previous GC identifers: GC17P073562 GC17P076610 GC17P074048 GC17P074182 GC17P074214 GC17P071096 GC17P069007
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Summariesfor MYO15B gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: MY15B_HUMAN, Q96JP2 Function : Unknown, due to the absence of a functional motor domainfRNAdb sequence ontology for MYO15B: mature_transcript - A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.
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Genomic Viewsfor MYO15B gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000017.10 NC_018928.1 NT_010783.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MYO15B gene promoter: Max1 TBP AML1a MyoD Lmo2 IRF-1 E47 AREB6 PPAR-gamma1 c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for MYO15B Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYO15B
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25 MYO15B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17P073586: view genomic region
(about GC identifiers )
Start:
73,584,139 bp from pter
End:
73,622,929 bp from pter
Size:
38,791 bases
Orientation:
plus strand
ORGUL member locations:Legend (see complete legend)
73584138 73603533 73622927 chr17
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Proteinsfor MYO15B gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MY15B_HUMAN, Q96JP2 (See
protein sequence )Recommended Name: Putative unconventional myosin-XVB Size : 1530 amino acids; 167118 Da
Subcellular location : Cytoplasm (Potential)
Caution : Could be the product of a pseudogene
Caution : Represents a unconventional myosin. This protein should not be confused with the conventional myosin-15(MYH15)
Sequence caution : Sequence=BAB47412.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for MYO15B :2DLP (3D)
 Explore the universe of human proteins at neXtProt for MYO15B: NX_Q96JP2 MYO15B Protein expression data from MOPED and PaxDb : About this image
ENSEMBL proteins: ENSP00000293201 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005856 cytoskeleton
-- --
MYO15B for ontologies About GeneDecksing MYO15B Antibody Products: Assay Products for MYO15B:
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Protein
Domains / Familiesfor MYO15B gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MYO15B for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q96JP2 ProtoNet protein and cluster: Q96JP2
UniProtKB/Swiss-Prot: MY15B_HUMAN, Q96JP2 Similarity : Contains 1 IQ domainSimilarity : Contains 1 myosin head-like domainSimilarity : Contains 1 MyTH4 domainSimilarity : Contains 1 SH3 domain
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Functionfor MYO15B gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: MY15B_HUMAN, Q96JP2 Function : Unknown, due to the absence of a functional motor domain
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO15B
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Pathways & Interactionsfor MYO15B gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYO15B STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)5/745 Interacting proteins for MYO15B (Q96JP2 2 , 3 ENSP00000293201 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 745 )Interactant Interaction Details GeneCard External ID(s) SSSCA1 O60232 2 , 3 , ENSP00000312318 4 MINT-66463 I2D:
score=1 STRING: ENSP00000312318 TRIM29 Q14134 2 , 3 , ENSP00000343129 4 MINT-68382 I2D:
score=1 STRING: ENSP00000343129 ZBTB8A Q96BR9 2 , 3 , ENSP00000362609 4 MINT-66590 I2D:
score=1 STRING: ENSP00000362609 NADSYN1 Q6IA69 2 , 3 , ENSP00000326424 4 MINT-67535 I2D:
score=1 STRING: ENSP00000326424 RAD54B Q9Y620 2 , 3 , ENSP00000336606 4 MINT-67305 I2D:
score=1 STRING: ENSP00000336606
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Drugs & Compoundsfor MYO15B gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for MYO15B Search CenterWatch for drugs/clinical trials and news about MYO15B
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Transcriptsfor MYO15B gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MYO15B gene: NM_001080847.1 Unigene Cluster for MYO15B:
Myosin XVB pseudogene Hs.390817 [show with all ESTs ] Unigene Representative Sequence: NR_003587 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000293201 (uc010wse.2 uc010dgi.1 uc002jor.1 uc002jos.4 )Additional cDNA sequence: AB058686.1 AF418286.1 AF418287.1 AF418288.1 AF418289.1 AF418290.1 AF418291.1 AF418292.1 AF418293.1 AK021565.1 AK025259.1 AK026339.1 AK074680.1 AK096869.1 AK097896.1 AK126458.1 AL713730.1 BC027875.1 BC033247.1 BC128044.1 NR_003587.2
24/25 DOTS entries (see all 25 ): DT.91698295 DT.95219972
DT.95128851 DT.100839076 DT.97762728 DT.92016722 DT.446323 DT.100788332 DT.91877344 DT.120933939 DT.91938197 DT.120933718 DT.120933861 DT.305713 DT.91677389 DT.95219967 DT.95219969 DT.97786836 DT.120933767 DT.91824797 DT.91839463 DT.95248710 DT.75101229 DT.91988960 24/186 AceView cDNA sequences (see all 186 ):
BU150940 BM666647 BQ709421 AA292802 AL713730 CA412202 BF476683 AI825877 BI766913 BQ574071 BE501985 BF899041 AV649878 AI283270 BC027875 BM996595 AI344135 BX504202 AB058686 BU615924 AI569620 CD244282 CB155174 BM977966 GeneLoc Exon Structure 5/22 Alternative Splicing Database (ASD) splice patterns (SP) for MYO15B (see all 22 ) About this scheme ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ SP1 :   -   -       -               -   -           -   -               SP2 :                                                     SP3 :                                                     SP4 :                                                     SP5 :                                                    
ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c ^ 29a · 29b · 29c · 29d ^ 30a · 30b ^ 31a · 31b · 31c ^ 32 ^ 33a · 33b ^ 34 ^ SP1 :                                                     SP2 :                                                     SP3 :           -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   SP4 :                                   -           -         SP5 :                                             -        
ExUns: 35a · 35b · 35c ^ 36a · 36b · 36c ^ 37a · 37b ^ 38a · 38b ^ 39a · 39b ^ 40 ^ 41 ^ 42a · 42b · 42c ^ 43 ^ 44a · 44b · 44c ^ 45a · 45b ^ 46 ^ 47 ^ 48a · SP1 :                                                     SP2 :                                       -   -             SP3 : -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -     SP4 : -                                                     SP5 : -                                                    
ExUns: 48b ^ 49 ^ 50 ^ 51 ^ 52 ^ 53 ^ 54 ^ 55 ^ SP1 :                 SP2 :                 SP3 :                 SP4 :                 SP5 :                
ECgene alternative splicing isoforms for MYO15B
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Expression for MYO15B gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MYO15B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGAGAAACAG
About this image MYO15B expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See MYO15B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MYO15B SOURCE GeneReport for Unigene cluster: Hs.390817 UniProtKB/Swiss-Prot: MY15B_HUMAN, Q96JP2 Tissue specificity : Detected in brain, stomach and kidney SABiosciences Custom PCR Arrays for MYO15B Primer Products: Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat MYO15B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MYO15B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MYO15B In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO15B
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Orthologsfor MYO15B gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for MYO15B gene from 6/10 species (see all 10 ) About this table
ENSEMBL Gene Tree for MYO15B (if available)TreeFam Gene Tree for MYO15B (if available)
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Paralogsfor MYO15B gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor MYO15B gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 17 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MYO15B (73584139 - 73622929 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 7 variations for MYO15B 7 CNVs : 53444 5031 49926 30025 30024 49928 29672
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor MYO15B gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Publicationsfor MYO15B gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MYO15B gene integrated from 9 sources : (articles sorted by number of sources associating them with MYO15B) Utopia : connect your pdf to the dynamic world of online information
A millennial myosin census. (PubMed id 11294886) 1 , 2 , 3 Berg J.S.... Cheney R.E. (2001) Human myosin XVBP is a transcribed pseudogene. (PubMed id 11964073) 1 , 2 , 9 Boger E.T.... Friedman T.B. (2001) Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906) 1 , 2 Nagase T.... Ohara O. (2001) Exploration of human ORFeome: high-throughput prepara tion of ORF clones and efficient characterization of their protein products. (PubMed id 18316326) 1 Nagase T....Ohara O. (2008) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 1 Rual J.F....Vidal M. (2005) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800) 1 Dias Neto E....Simpson A.J.G. (2000) (PubMed id 15608161) 10
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External Searches for MYO15B gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MYO15B gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MYO15B gene
(According to HUGE )
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Specialized Databases showing MYO15B gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for MYO15B Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MYO15B gene: Search GeneIP for patents involving MYO15B GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MYO15B gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MYO15B Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYO15B QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYO15B QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MYO15B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MYO15B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MYO15B
Search Tocris compounds for MYO15B
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO15B
Search ThermoFisher Antibodies for MYO15B
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MYO15B
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