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MYO15A Gene

protein-coding   GIFtS: 49
GCID: GC17P018012

Myosin XVA


(Previous symbols: DFNB3, MYO15)
  See MYO15A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin XVA1 2
MYO151 2 3
DFNB31 2 5
Unconventional Myosin-152 3
myosin-XV2
Unconventional Myosin-XV2

External Ids:    HGNC: 75941   Entrez Gene: 511682   Ensembl: ENSG000000915367   OMIM: 6026665   UniProtKB: Q9UKN73   

Export aliases for MYO15A gene to outside databases

Previous GC identifers: GC17P018257 GC17P019384 GC17P017955 GC17P018212 GC17P017952 GC17P017765


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYO15A Gene:
This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long
N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary
for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with
profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome
region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified,
but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been
described, but their full length sequences have not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for MYO15A Gene:
MYO15A (myosin XVA) is a protein-coding gene. Diseases associated with MYO15A include dfnb 3 nonsyndromic hearing loss and deafness, and deafness, autosomal recessive 3. GO annotations related to this gene include motor activity and actin binding. An important paralog of this gene is MYO1D.

UniProtKB/Swiss-Prot: MYO15_HUMAN, Q9UKN7
Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in
intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which
would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles
(By similarity)

Gene Wiki entry for MYO15A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYO15A gene promoter:
         SRF   Egr-3   Bach1   POU6F1 (c2)   HNF-3beta   POU2F1   POU2F1a   ARP-1   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYO15A promoter sequence
   Search Chromatin IP Primers for MYO15A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYO15A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

MYO15A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYO15A gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P018012:  view genomic region     (about GC identifiers)

Start:
18,012,020 bp from pter      End:
18,083,116 bp from pter
Size:
71,097 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MYO15_HUMAN, Q9UKN7 (See protein sequence)
Recommended Name: Unconventional myosin-XV  
Size: 3530 amino acids; 395293 Da
Subunit: Interacts with the third PDZ domain of WHRN which is necessary for localization of WHRN to stereocilium
tips. Interacts with EPS8 (By similarity). Interacts with FASLG
Caution: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-15
(MYH15)

Explore the universe of human proteins at neXtProt for MYO15A: NX_Q9UKN7

Explore proteomics data for MYO15A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYO15A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057323.3  
    ENSEMBL proteins: 
     ENSP00000205890   ENSP00000408800   ENSP00000464462   ENSP00000451782   ENSP00000451925  
     ENSP00000467989   ENSP00000465910   ENSP00000466630   ENSP00000409098  

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for MYO15A (2 products) 

     
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    antibodies-online kits for MYO15A (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MYOXV: Myosins / Myosin superfamily : Class XV

    Selected InterPro protein domains (see all 9):
     IPR019748 FERM_central
     IPR001452 SH3_domain
     IPR011511 SH3_2
     IPR027417 P-loop_NTPase
     IPR000857 MyTH4_dom

    Graphical View of Domain Structure for InterPro Entry Q9UKN7

    ProtoNet protein and cluster: Q9UKN7

    4 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB000857 Core domain in kinesin and myosin motor
    IPB001452 SH3 domain signature
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: MYO15_HUMAN, Q9UKN7
    Similarity: Contains 1 FERM domain
    Similarity: Contains 3 IQ domains
    Similarity: Contains 1 myosin head-like domain
    Similarity: Contains 2 MyTH4 domains
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with MYO15A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYO15_HUMAN, Q9UKN7
    Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in
    intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which
    would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles
    (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
    GO:0005516calmodulin binding IEA--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with MYO15A           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Myo15):
     behavior/neurological  growth/size/body  hearing/vestibular/ear  nervous system 

    Find genes that share phenotypes with MYO15A           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYO15A
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    7 qRT-PCR Assays for microRNAs that regulate MYO15A:
    hsa-miR-3673 hsa-miR-206 hsa-miR-637 hsa-miR-491-5p hsa-miR-3151 hsa-miR-1 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidMYO15A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MYO15A

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYO15_HUMAN, Q9UKN7: Cell projection, stereocilium (By similarity). Cytoplasm, cytoskeleton (By similarity).
    Note=Localizes to stereocilium tips in cochlear and vestibular hair cells (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton ----
    GO:0016459myosin complex IEA--
    GO:0032420stereocilium IEA--
    GO:0032421stereocilium bundle ----

    Find genes that share ontologies with MYO15A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYO15A About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    2Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35
    3RhoGDI Pathway
    Fc-GammaR-Mediated Phagocytosis in Macrophages0.33
    RhoGDI Pathway0.33
    4ERK Signaling
    ILK Signaling0.49
    5Sweet Taste Signaling
    Cellular Effects of Sildenafil0.46

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYO15A (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYO15A
    Interactions:

        Search GeneGlobe Interaction Network for MYO15A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for MYO15A (Q9UKN73 ENSP000002058904) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DFNB31Q9P2023, ENSP000003546234I2D: score=6 STRING: ENSP00000354623
    EPS8Q129293, ENSP000002811724I2D: score=4 STRING: ENSP00000281172
    FASLGP480233, ENSP000003566944I2D: score=1 STRING: ENSP00000356694
    USP13Q929953I2D: score=4 
    GBE1ENSP000004108334STRING: ENSP00000410833
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007605sensory perception of sound IEA--
    GO:0007626locomotory behavior IEA--
    GO:0042472inner ear morphogenesis IEA--

    Find genes that share ontologies with MYO15A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYO15A (MYO15)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYO15A gene: 
    NM_016239.3  

    Unigene Cluster for MYO15A:

    Myosin XVA
    Hs.462390  [show with all ESTs]
    Unigene Representative Sequence: NM_016239
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000205890(uc021trl.1 uc021trm.1) ENST00000583079 ENST00000412324
    ENST00000578999 ENST00000418233(uc010vxi.2 uc010vxl.1 uc010vxm.2 uc010cpv.3)
    ENST00000536811(uc010vxj.1) ENST00000445289(uc010vxk.1) ENST00000585180
    ENST00000556535 ENST00000557190 ENST00000557655 ENST00000578472 ENST00000433411(uc002gsl.3)
    ENST00000579848 ENST00000473013(uc002gsm.1) ENST00000578575 ENST00000451725

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    hsa-miR-3673 hsa-miR-206 hsa-miR-637 hsa-miR-491-5p hsa-miR-3151 hsa-miR-1 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidMYO15A 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF144094.1 AK294036.1 AK297179.1 AK297641.1 AK298825.1 AK300529.1 AK310232.1 

    4 DOTS entries:

    DT.40126983  DT.99988249  DT.415782  DT.95097409 

    Selected AceView cDNA sequences (see all 309):

    BF223206 CK823441 BG250562 AL713794 BI768080 CR602137 BM709212 AA405448 
    BI255896 BI909797 BM848313 NM_001388 CB153546 CR620496 BQ706376 BE550595 
    AW016504 BI752795 BM547604 CA495284 CR591061 AW594545 CR619498 AU141267 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYO15A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTATTCCCT
    MYO15A Expression
    About this image

    MYO15A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYO15A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.462390

    UniProtKB/Swiss-Prot: MYO15_HUMAN, Q9UKN7
    Tissue specificity: Highly expressed in pituitary. Also expressed at lower levels in adult brain, kidney, liver,
    lung, pancreas, placenta and skeletal muscle. Not expressed in brain. In the pituitary, highly expressed in
    anterior gland cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MYO15A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myo151 , 5 myosin XV1, 5 82.06(n)1
    83.41(a)1
      11 (37.81 cM)5
    179101  NM_010862.21  NP_034992.21 
     604693395 
    chicken
    (Gallus gallus)
    Aves MYO15A1 myosin XVA 67.68(n)
    63(a)
      101750031  XM_004945363.1  XP_004945420.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYO15A6
    myosin XVA
    65(a)
    1 ↔ 1
    GL344450.1(4471-32852)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia myo15a1 myosin XVA 61.43(n)
    58.48(a)
      100488159  XM_002935856.2  XP_002935902.2 
    zebrafish
    (Danio rerio)
    Actinopterygii myo15aa1 myosin XVAa 65.06(n)
    63.31(a)
      560592  XM_001924016.3  XP_001924051.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Myo10A3 myosin ATPase 42(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea hum-43 myosin like 26(a)   X(11455973-11472842)   --


    ENSEMBL Gene Tree for MYO15A (if available)
    TreeFam Gene Tree for MYO15A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYO15A gene
    MYO1D2  MYO1C2  MYO1A2  MYO1F2  MYO1G2  MYO1B2  MYO15B2  MYO1E2  
    MYO1H2  MYO192  
    Selected SIMAP similar genes for MYO15A using alignment to 9 protein entries:     MYO15_HUMAN (see all proteins) (see all similar genes):
    DKFZp686N18198    DKFZp434O1119    MYO10    MYH11    MYH9    MYO1B
    MYO1D    MYO5B    MYO5C    MYO1A    MYO1E    DKFZp667C0210
    FLJ00395    MYO1F variant protein    MYH1    MYO1C    DKFZp686A01173    MYH2

    Find genes that share paralogs with MYO15A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYO15A (see all 1834)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0103034
    Deafness, autosomal recessive, 3 (DFNB3)4--see VAR_0103032 N Y mis40--------
    VAR_0103044
    Deafness, autosomal recessive, 3 (DFNB3)4--see VAR_0103042 I F mis40--------
    VAR_0379644
    Deafness, autosomal recessive, 3 (DFNB3)4--see VAR_0379642 Q H mis40--------
    rs1219089701,2,,4
    C,Fpathogenic118039425(+) CCGCAC/TCTTAC 2 T I mis11Minor allele frequency- T:0.01EU 1323
    rs75026811,2
    C--17768040(+) aaaaaA/Gaaaaa 1 -- int1 trp30--------
    rs670241941,2
    C--17773600(+) AAAAA-/A/GAAAGA 1 -- int10--------
    rs673668751,2
    C--17773603(+) AAAAAA/GAAAGA 1 -- int10--------
    rs665391611,2
    C--17782208(+) AATAC-/AAAAAA 1 -- int12Minor allele frequency- A:0.25NA CSA 4
    rs2013826031,2
    C--17806652(-) CCTTTC/TTTTTT 1 -- int10--------
    rs341834421,2
    C--17998017(+) TTTTT-/T/TT  
            
    GAGAC
    1 -- us2k11NA 2

    HapMap Linkage Disequilibrium report for MYO15A (18012020 - 18083116 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MYO15A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510702CNV Loss20534489
    dgv3077n71CNV Loss21882294
    nsv470580CNV Loss18288195
    nsv457697CNV Loss19166990
    nsv907769CNV Loss21882294
    nsv827912CNV Gain20364138
    nsv155OTHER Inversion15895083
    nsv499114OTHER Inversion21111241

    Human Gene Mutation Database (HGMD): MYO15A
    Locus Specific Mutation Databases (LSDB): MYO15A

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602666   
    OMIM disorders: 600316  
    UniProtKB/Swiss-Prot: MYO15_HUMAN, Q9UKN7
  • Deafness, autosomal recessive, 3 (DFNB3) [MIM:600316]: A form of non-syndromic sensorineural hearing
    loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to
    the brain, or the area of the brain that receives sound information. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 5 diseases for MYO15A:    
    About MalaCards
    dfnb 3 nonsyndromic hearing loss and deafness    deafness, autosomal recessive 3    mitochondrial complex v deficiency, mitochondrial 1    mitochondrial complex v deficiency
    deafness, autosomal recessive 76

    1 disease from the University of Copenhagen DISEASES database for MYO15A:
    Nonsyndromic deafness

    Find genes that share disorders with MYO15A           About GenesLikeMe

    3 Novoseek inferred disease relationships for MYO15A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dfnb3 99.1 12 19274735 (2), 17851452 (1), 11735029 (1), 17853461 (1) (see all 8)
    dfnb2 90.3 1 11101839 (1)
    congenital deafness 79.7 1 10704189 (1)


    Export disorders for MYO15A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for MYO15A gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with MYO15A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of unconventional myosin MYO15 mutations with human nonsyndromic deafness DFNB3. (PubMed id 9603736)1, 2, 3, 9 Wang A....Friedman T.B. (Science 1998)
    2. Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2. (PubMed id 10552926)1, 2, 9 Liang Y....Fridell R.A. (Genomics 1999)
    3. Novel mutations of MYO15A associated with profound deafness in consanguineous families and moderately severe hearing loss in a patient with Smith-Magenis syndrome. (PubMed id 11735029)1, 2, 9 Liburd N.... Friedman T.B. (Hum. Genet. 2001)
    4. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M.... Janssen O. (BMC Immunol. 2009)
    5. MYO15A (DFNB3) mutations in Turkish hearing loss families and functional modeling of a novel motor domain mutation. (PubMed id 17853461)1, 9 Kalay E....Kremer H. (Am. J. Med. Genet. A 2007)
    6. Myosin XVA expression in the pituitary and in other neuroendocrine tissues and tumors. (PubMed id 11583965)1, 9 Lloyd R.V....Friedman T.B. (Am. J. Pathol. 2001)
    7. Mutations in the first MyTH4 domain of MYO15A are a common cause of DFNB3 hearing loss. (PubMed id 19274735)1, 9 Shearer A.E....Najmabadi H. (Laryngoscope 2009)
    8. Mutational spectrum of MYO15A: the large N-terminal extension of myosin XVA is required for hearing. (PubMed id 17546645)1, 9 Nal N....Friedman T.B. (Hum. Mutat. 2007)
    9. Whole-exome sequencing identifies MYO15A mutations as a cause of autosomal recessive nonsyndromic hearing loss in Korean families. (PubMed id 23865914)1 Woo H.M....Koo S.K. (BMC Med. Genet. 2013)
    10. Screening for MYO15A gene mutations in autosomal recessive nonsyndromic, GJB2 negative Iranian deaf population. (PubMed id 22736430)1 Fattahi Z....Najmabadi H. (Am. J. Med. Genet. A 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 51168 HGNC: 7594 AceView: DRG2andMYO15A Ensembl:ENSG00000091536 euGenes: HUgn51168
    ECgene: MYO15A H-InvDB: MYO15A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MYO15A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MYO15A gene:
    Search GeneIP for patents involving MYO15A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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