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MYO10 Gene

protein-coding   GIFtS: 62
GCID: GC05M016662

Myosin X

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin X1 2
Unconventional Myosin-102 3
myosin-X2
Unconventional Myosin-X2
Unconventionnal Myosin-X2
KIAA07993

External Ids:    HGNC: 75931   Entrez Gene: 46512   Ensembl: ENSG000001455557   OMIM: 6014815   UniProtKB: Q9HD673   

Export aliases for MYO10 gene to outside databases

Previous GC identifers: GC05M016655 GC05M016944 GC05M016698 GC05M016718


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYO10 Gene:
This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should
not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic
domains of conventional myosins and are further distinguished from class members by their tail domains. This gene
functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule
cytoskeletons during meiosis. (provided by RefSeq, Dec 2011)

GeneCards Summary for MYO10 Gene:
MYO10 (myosin X) is a protein-coding gene. GO annotations related to this gene include calmodulin binding and phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is MYO3A.

UniProtKB/Swiss-Prot: MYO10_HUMAN, Q9HD67
Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in
intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed
motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or
integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell
adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon
guidance. Plays a role in formation of the podosome belt in osteoclasts (By similarity)

Gene Wiki entry for MYO10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYO10 gene promoter:
         c-Fos   AP-1   JunB   Fra-1   FosB   FOXD1   S8   JunD   aMEF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYO10 promoter sequence
   Search Chromatin IP Primers for MYO10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYO10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.1-p14.3   Ensembl cytogenetic band:  5p15.1   HGNC cytogenetic band: 5p15.1-p14.3

MYO10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYO10 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M016662:  view genomic region     (about GC identifiers)

Start:
16,662,016 bp from pter      End:
16,936,385 bp from pter
Size:
274,370 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MYO10_HUMAN, Q9HD67 (See protein sequence)
Recommended Name: Unconventional myosin-X  
Size: 2058 amino acids; 237347 Da
Subunit: Monomer, when in an inactive confomation in the cytosol. Homodimer in its active, membrane-bound
conformation. Interacts with CALM. Interacts with ECM29. Interacts with NEO1. Interacts with ITGB1 and ITGB3 (By
similarity). Interacts with DCC and ITGB5; the presence of DCC inhibits ITGB5 binding. Interacts with tubulin;
ITGB5 or DCC binding inhibits tubulin binding
Caution: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-10
(MYH10)
Sequence caution: Sequence=BAA34519.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from and Proteopedia for MYO10:
2LW9 (3D)        3AU4 (3D)        3AU5 (3D)        3PZD (3D)    
Secondary accessions: A7E2D1 O94893 Q9NYM7 Q9P110 Q9P111 Q9UHF6

Explore the universe of human proteins at neXtProt for MYO10: NX_Q9HD67

Explore proteomics data for MYO10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYO10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036466.2  
    ENSEMBL proteins: 
     ENSP00000421280   ENSP00000425051   ENSP00000421170   ENSP00000421309   ENSP00000426783  
     ENSP00000426664   ENSP00000274203   ENSP00000391106  
    Reactome Protein details: Q9HD67

    MYO10 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for MYO10
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    Search eBioscience for ELISAs for MYO10 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    MYOX: Myosins / Myosin superfamily : Class X

    Selected InterPro protein domains (see all 10):
     IPR019748 FERM_central
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR014352 FERM/acyl-CoA-bd_prot_3-hlx
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9HD67

    ProtoNet protein and cluster: Q9HD67

    3 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB000857 Core domain in kinesin and myosin motor
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: MYO10_HUMAN, Q9HD67
    Domain: Interaction between the motor domain and the tail leads to an inactive, monomeric conformation.
    Phospholipid binding via the PH domains leads to the formation of the active, dimeric form of the protein and
    strongly increases actin-dependent ATPase activity and motor activity (By similarity)
    Domain: Interacts with membranes containing phosphatidylinositol-3,4,5-trisphosphate via the PH domains (By
    similarity)
    Similarity: Contains 1 FERM domain
    Similarity: Contains 3 IQ domains
    Similarity: Contains 1 myosin head-like domain
    Similarity: Contains 1 MyTH4 domain
    Similarity: Contains 2 PH domains


    Find genes that share domains with MYO10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYO10_HUMAN, Q9HD67
    Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in
    intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed
    motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or
    integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell
    adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon
    guidance. Plays a role in formation of the podosome belt in osteoclasts (By similarity)

         Genatlas biochemistry entry for MYO10:
    myosin X,unconventional,apparently non filamentous,homologous to mouse Myo10,and porcine myosin VIIB

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity ----
    GO:0005515protein binding IPI18570893
    GO:0005516calmodulin binding IEA--
    GO:0005524ATP binding IEA--
    GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding ISS--
         
    Find genes that share ontologies with MYO10           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Myo10 (no phenotypes)

    Find genes that share phenotypes with MYO10           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYO10
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    miRNA
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    hsa-mir-484 (MIRT041895), hsa-mir-26a-5p (MIRT050130), hsa-mir-183-5p (MIRT047146), hsa-mir-155-5p (MIRT001532), hsa-mir-30a-5p (MIRT005212)

    Block miRNA regulation of human, mouse, rat MYO10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYO10 (see all 86):
    hsa-miR-140-5p hsa-miR-548j hsa-miR-199a-3p hsa-miR-218-1* hsa-miR-374a hsa-miR-29a* hsa-miR-548a-5p hsa-miR-130b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYO10_HUMAN, Q9HD67: Cytoplasm, cytosol. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm,
    cytoskeleton. Cell projection, filopodium tip. Cytoplasm, cell cortex. Cell projection, filopodium membrane;
    Peripheral membrane protein (By similarity). Note=May be in an inactive, monomeric conformation in the cytosol.
    Detected in cytoplasmic punctae and in cell projections. Colocalizes with actin fibers. Undergoes forward and
    rearward movements within filopodia. Interacts with microtubules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    plasma membrane5
    nucleus4

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ----

    Find genes that share ontologies with MYO10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYO10 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    2Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    3Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35
    4L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    5RhoGDI Pathway
    Fc-GammaR-Mediated Phagocytosis in Macrophages0.33
    RhoGDI Pathway0.33


    Find genes that share SuperPaths with MYO10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYO10 (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions

    2 Reactome Pathways for MYO10
        Netrin-1 signaling
    Regulation of actin dynamics for phagocytic cup formation


    1 Kegg Pathway  (Kegg details for MYO10):
        Fc gamma R-mediated phagocytosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYO10
    Interactions:

        GeneGlobe Interaction Network for MYO10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYO10 (Q9HD671, 2, 3 ENSP000003911064) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCCP431461, 2, 3, ENSP000003891404EBI-307061,EBI-1222919 MINT-8199123 MINT-8199598 MINT-8199637 MINT-8199109 MINT-8199139 MINT-8199557 MINT-8199615 MINT-8199775 I2D: score=1 STRING: ENSP00000389140
    CALM2P621581, 2, 3EBI-307061,EBI-397435 MINT-6595938 MINT-6596013 I2D: score=3 
    ITGB5P180841, 2, 3, ENSP000002961814EBI-307061,EBI-1223434 MINT-8199775 MINT-8199748 I2D: score=3 STRING: ENSP00000296181
    CALML3P274821, 2, 3, ENSP000003152994EBI-307061,EBI-747537 MINT-6595901 MINT-6596000 I2D: score=2 STRING: ENSP00000315299
    TUBB2BQ9BVA12, 3, ENSP000002598184MINT-8199713 I2D: score=1 STRING: ENSP00000259818
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    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process ISS--
    GO:0007165signal transduction ----
    GO:0007411axon guidance TAS--
    GO:0008152metabolic process ISS--
    GO:0008360regulation of cell shape IMP16894163

    Find genes that share ontologies with MYO10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYO10



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYO10 gene: 
    NM_012334.2  

    Unigene Cluster for MYO10:

    Myosin X
    Hs.481720  [show with all ESTs]
    Unigene Representative Sequence: NM_012334
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513610(uc011cnb.2 uc011cnc.2 uc011cnd.2 uc011cne.2 uc010itx.3 uc003jft.4 uc003jfu.2)
    ENST00000515803 ENST00000505695 ENST00000513882 ENST00000506343 ENST00000512061
    ENST00000510401 ENST00000508318 ENST00000511972 ENST00000502436 ENST00000507288(uc003jfv.2)
    ENST00000274203 ENST00000427430
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    hsa-miR-140-5p hsa-miR-548j hsa-miR-199a-3p hsa-miR-218-1* hsa-miR-374a hsa-miR-29a* hsa-miR-548a-5p hsa-miR-130b
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      QuantiFast Probe-based Assays in human, mouse, rat MYO10

    Additional mRNA sequence: 

    AB018342.2 AF132021.1 AF132022.1 AF184153.1 AF234532.1 AF247457.2 AK001501.1 AK024719.1 
    AK025921.1 AK027764.1 AK074717.1 AK125246.1 AK295630.1 AK295736.1 AK303459.1 AK316138.1 
    AL832428.1 BC014956.1 BC032669.1 BC041694.1 BC050682.1 BC071965.1 BC094838.1 BC108736.1 
    BC137168.1 BC150285.1 

    Selected DOTS entries (see all 25):

    DT.453025  DT.120804177  DT.440413  DT.100042155  DT.100034484  DT.91901575  DT.105454  DT.439717 
    DT.95108967  DT.120804155  DT.120804227  DT.75146192  DT.97797041  DT.100042154  DT.120804152  DT.91770913 
    DT.100789920  DT.120804192  DT.91792263  DT.95108966  DT.100641566  DT.120833566  DT.424542  DT.95108971 

    Selected AceView cDNA sequences (see all 319):

    AK074717 BU161243 AA620722 AL832428 N59341 AW118975 AI539831 AK024719 
    AW069458 H98978 T35509 T16435 NM_012334 BI522546 AU132394 N35986 
    BE502366 BU685713 CD517708 BM932276 CA488271 AI376620 N50260 T33166 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYO10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAAACTGTT
    MYO10 Expression
    About this image


    MYO10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 8 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    MYO10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYO10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.481720

    UniProtKB/Swiss-Prot: MYO10_HUMAN, Q9HD67
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for MYO10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYO10 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myo101 , 5 myosin X1, 5 87.28(n)1
    94.31(a)1
      15 (9.36 cM)5
    179091  NM_019472.21  NP_062345.21 
     256225255 
    chicken
    (Gallus gallus)
    Aves MYO101 myosin X 78.26(n)
    87.49(a)
      420913  XM_419000.4  XP_419000.4 
    lizard
    (Anolis carolinensis)
    Reptilia MYO106
    myosin X
    85(a)
    1 ↔ 1
    4(60009096-60144194)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.241472 Xenopus laevis transcribed sequence with moderate similarity more 77.62(n)    BJ072146.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc04d082 Transcribed sequence with moderate similarity to protein more 74.54(n)    57045444 
    fruit fly
    (Drosophila melanogaster)
    Insecta d3 myosin ATPase 30(a)   2 29D1   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MYO46
    MYO26
    One of two type V myosin motors (along with MYO2) ...
    One of two type V myosin motors (along with MYO4) ...
    24(a)
    24(a)
    many ↔ many
    many ↔ many
    I(87855-92270) YAL029C
    XV(925721-930445) YOR326W


    ENSEMBL Gene Tree for MYO10 (if available)
    TreeFam Gene Tree for MYO10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYO10 gene
    MYO3A2  MYO9A2  MYO5C2  MYO7A2  MYO162  MYO9B2  MYO5A2  MYO7B2  
    PLEKHH32  MYO5B2  MYO62  MYO3B2  
    Selected SIMAP similar genes for MYO10 using alignment to 7 protein entries:     MYO10_HUMAN (see all proteins) (see all similar genes):
    DKFZp762A083    MYO15A    MYO9B variant protein    MYO1G    MYH13    MYH3
    MYO3A    MYO5C    MYH6    MYO1B    MYO9A    MYO9B
    MYO1C    MYO6    MYO1E    MYO5A    MYH10    MYH7B

    Find genes that share paralogs with MYO10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYO10 (see all 7070)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1532021,2
    C,F,O,A,H--16661569(-) CTGGGC/TGCTCA 1 -- ds500124Minor allele frequency- T:0.14EA NA NS WA 2972
    rs1425228111,2
    --16661738(+) AGATTA/CATGCA 1 -- ds50010--------
    rs175010441,2
    C,F,H--16661843(+) TGCTTC/GTAAAG 1 -- ds500114Minor allele frequency- G:0.04NA NS EA 1096
    rs737551061,2
    C,F--16661862(+) CTTCCA/GTAATT 1 -- ds50012Minor allele frequency- G:0.07WA 120
    rs1511113851,2
    --16661897(+) CTTTCC/TATGAA 1 -- ds50010--------
    rs749585531,2
    C--16662019(+) GATCTG/ATTTCA 1 -- ut311Minor allele frequency- A:0.01NA 120
    rs1907852091,2
    --16662296(+) TAAAGC/GGCTTA 1 -- ut310--------
    rs135371,2
    C,F,A,H--16662297(-) ATAAGC/TGCTTT 1 -- ut3127Minor allele frequency- T:0.46MN NS EA NA WA CSA 2859
    rs1532011,2
    C,F--16662303(-) ATAAAA/CATAAG 1 -- ut311Minor allele frequency- C:0.02EA 120
    rs587758761,2
    C--16662449(+) TTTTT-/TTTTT 
    /TTTTTTT
    GGAGA
    3 -- ut31 cds11NA 2

    HapMap Linkage Disequilibrium report for MYO10 (16662016 - 16912016 bp, first 250kb of MYO10)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MYO10 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2729841CNV Deletion23290073
    esv2676823CNV Deletion23128226
    esv2667787CNV Deletion23128226
    esv2673450CNV Deletion23128226
    dgv1014e199CNV Deletion23128226
    esv2729842CNV Deletion23290073
    esv1329295CNV Insertion17803354
    esv274094CNV Insertion20981092
    esv1009519CNV Insertion20482838
    esv268284CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYO10
    DNA2.0 Custom Variant and Variant Library Synthesis for MYO10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601481    OMIM disorders: --


    Find genes that share disorders with MYO10           About GenesLikeMe

    Genetic Association Database (GAD): MYO10
    Human Genome Epidemiology (HuGE) Navigator: MYO10 (2 documents)

    Export disorders for MYO10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYO10 gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with MYO10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin. (PubMed id 10984435)1, 2, 9 Berg J.S.... Cheney R.E. (J. Cell Sci. 2000)
    2. Myosin-X is a molecular motor that functions in filopodia formation. (PubMed id 16894163)1, 2, 9 Bohil A.B.... Cheney R.E. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    3. Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain. (PubMed id 21642953)1, 2 Hirano Y....Hakoshima T. (EMBO J. 2011)
    4. Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain. (PubMed id 21321230)1, 2 Wei Z.... Zhang M. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    5. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PubMed id 20682791)1, 2 Gorbea C.... Rechsteiner M. (J. Biol. Chem. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1, 4 Chapuis J....Lambert J.C. (Mol. Psychiatry 2009)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. Physical map and characterization of transcripts in the candidate interval for familial chondrocalcinosis at chromosome 5p15.1. (PubMed id 10610710)1, 2 Rojas K.... Williams C.J. (Genomics 1999)
    10. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4651 HGNC: 7593 AceView: MYO10 Ensembl:ENSG00000145555 euGenes: HUgn4651
    ECgene: MYO10 Kegg: 4651 H-InvDB: MYO10

    (According to HUGE)
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    HUGE: KIAA0799

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYO10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYO10 gene:
    Search GeneIP for patents involving MYO10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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