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Aliases for MYO10 Gene

Aliases for MYO10 Gene

  • Myosin X 2 3 5
  • Unconventional Myosin-10 3 4
  • Unconventionnal Myosin-X 3
  • Myosin-X 3
  • KIAA0799 4

External Ids for MYO10 Gene

Previous GeneCards Identifiers for MYO10 Gene

  • GC05M016655
  • GC05M016944
  • GC05M016698
  • GC05M016718

Summaries for MYO10 Gene

Entrez Gene Summary for MYO10 Gene

  • This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]

GeneCards Summary for MYO10 Gene

MYO10 (Myosin X) is a Protein Coding gene. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and ERK Signaling. GO annotations related to this gene include calmodulin binding and motor activity. An important paralog of this gene is MYO7B.

UniProtKB/Swiss-Prot for MYO10 Gene

  • Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts.

  • Isoform Headless: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity).

Gene Wiki entry for MYO10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO10 Gene

Genomics for MYO10 Gene

Regulatory Elements for MYO10 Gene

Enhancers for MYO10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MYO10 on UCSC Golden Path with GeneCards custom track

Promoters for MYO10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MYO10 on UCSC Golden Path with GeneCards custom track

Genomic Location for MYO10 Gene

Chromosome:
5
Start:
16,661,907 bp from pter
End:
16,936,276 bp from pter
Size:
274,370 bases
Orientation:
Minus strand

Genomic View for MYO10 Gene

Genes around MYO10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO10 Gene

Proteins for MYO10 Gene

  • Protein details for MYO10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD67-MYO10_HUMAN
    Recommended name:
    Unconventional myosin-X
    Protein Accession:
    Q9HD67
    Secondary Accessions:
    • A7E2D1
    • O94893
    • Q8IVX5
    • Q9NYM7
    • Q9P110
    • Q9P111
    • Q9UHF6

    Protein attributes for MYO10 Gene

    Size:
    2058 amino acids
    Molecular mass:
    237347 Da
    Quaternary structure:
    • Monomer, when in an inactive confomation in the cytosol. Homodimer in its active, membrane-bound conformation; antiparallel coiled coil-mediated dimer formation. Interacts strongly with CALM3 and weakly with CALM, the CALM3 interaction is essential for function in filopodial extension and motility. Interacts with ECM29. Interacts with NEO1. Interacts with ITGB1 and ITGB3. Interacts with VASP (By similarity). Interacts with DCC and ITGB5; the presence of DCC inhibits ITGB5 binding. Interacts with tubulin; ITGB5 or DCC binding inhibits tubulin binding.
    SequenceCaution:
    • Sequence=BAA34519.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MYO10 Gene

    Alternative splice isoforms for MYO10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO10 Gene

Proteomics data for MYO10 Gene at MOPED

Post-translational modifications for MYO10 Gene

Other Protein References for MYO10 Gene

No data available for DME Specific Peptides for MYO10 Gene

Domains & Families for MYO10 Gene

Suggested Antigen Peptide Sequences for MYO10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HD67

UniProtKB/Swiss-Prot:

MYO10_HUMAN :
  • Interaction between the motor domain and the tail leads to an inactive, monomeric conformation. Phospholipid binding via the PH domains leads to the formation of the active, dimeric form of the protein and strongly increases actin-dependent ATPase activity and motor activity (By similarity).
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • Interaction between the motor domain and the tail leads to an inactive, monomeric conformation. Phospholipid binding via the PH domains leads to the formation of the active, dimeric form of the protein and strongly increases actin-dependent ATPase activity and motor activity (By similarity).
  • Interacts with membranes containing phosphatidylinositol-3,4,5-trisphosphate via the PH domains.
  • IQ 3 domain mediates high-affinity calcium-dependent binding to CALM3/CLP.
  • The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha-helical structure by ionic bonds. It can refold after extension suggesting an in vivo force-dependent function. The isolated SAH domain is monomeric; however, in its distal part seems to form a semirigid helical structure which overlaps with a region shown to mediate antiparallel coiled coil-mediated dimerization.
  • Contains 1 FERM domain.
  • Contains 3 IQ domains.
  • Contains 1 myosin motor domain.
  • Contains 1 MyTH4 domain.
  • Contains 2 PH domains.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO10: view

Function for MYO10 Gene

Molecular function for MYO10 Gene

GENATLAS Biochemistry:
myosin X,unconventional,apparently non filamentous,homologous to mouse Myo10,and porcine myosin VIIB
UniProtKB/Swiss-Prot Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts.
UniProtKB/Swiss-Prot Function:
Isoform Headless: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity).

Gene Ontology (GO) - Molecular Function for MYO10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding ISS --
GO:0051015 actin filament binding ISS --
genes like me logo Genes that share ontologies with MYO10: view
genes like me logo Genes that share phenotypes with MYO10: view

Animal Models for MYO10 Gene

MGI Knock Outs for MYO10:

Animal Model Products

miRNA for MYO10 Gene

miRTarBase miRNAs that target MYO10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYO10 Gene

Localization for MYO10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO10 Gene

Cytoplasm, cytosol. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Cell projection, filopodium tip. Cytoplasm, cell cortex. Cell projection, filopodium membrane; Peripheral membrane protein. Note=May be in an inactive, monomeric conformation in the cytosol. Detected in cytoplasmic punctae and in cell projections. Colocalizes with actin fibers. Undergoes forward and rearward movements within filopodia. Interacts with microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO10 Gene COMPARTMENTS Subcellular localization image for MYO10 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
cytoskeleton 4

Gene Ontology (GO) - Cellular Components for MYO10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0030175 filopodium IEA --
GO:0031527 filopodium membrane IEA --
GO:0032433 filopodium tip ISS --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with MYO10: view

Pathways & Interactions for MYO10 Gene

genes like me logo Genes that share pathways with MYO10: view

Gene Ontology (GO) - Biological Process for MYO10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007411 axon guidance TAS --
GO:0045087 innate immune response TAS --
GO:0051489 regulation of filopodium assembly IMP 16894163
genes like me logo Genes that share ontologies with MYO10: view

No data available for SIGNOR curated interactions for MYO10 Gene

Drugs & Compounds for MYO10 Gene

No Compound Related Data Available

Transcripts for MYO10 Gene

Unigene Clusters for MYO10 Gene

Myosin X:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYO10 Gene

No ASD Table

Relevant External Links for MYO10 Gene

GeneLoc Exon Structure for
MYO10
ECgene alternative splicing isoforms for
MYO10

Expression for MYO10 Gene

mRNA expression in normal human tissues for MYO10 Gene

Protein differential expression in normal tissues from HIPED for MYO10 Gene

This gene is overexpressed in Plasma (39.2), Pancreas (16.1), and Heart (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYO10 Gene



SOURCE GeneReport for Unigene cluster for MYO10 Gene Hs.481720

mRNA Expression by UniProt/SwissProt for MYO10 Gene

Q9HD67-MYO10_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with MYO10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for MYO10 Gene

Orthologs for MYO10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYO10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYO10 35
  • 88.12 (n)
  • 93.48 (a)
MYO10 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYO10 35
  • 86.9 (n)
  • 92.23 (a)
MYO10 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myo10 35
  • 87.28 (n)
  • 94.31 (a)
Myo10 16
Myo10 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYO10 35
  • 99.45 (n)
  • 99.76 (a)
MYO10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myo10 35
  • 87.32 (n)
  • 94.9 (a)
oppossum
(Monodelphis domestica)
Mammalia MYO10 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYO10 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYO10 35
  • 78.26 (n)
  • 87.49 (a)
MYO10 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYO10 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20076 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24147 35
zebrafish
(Danio rerio)
Actinopterygii myo10 35
  • 66.48 (n)
  • 69.06 (a)
wufc04d08 35
myo10 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta d 37
  • 30 (a)
Myo10A 36
  • 18 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO2 36
  • 24 (a)
ManyToMany
MYO4 36
  • 24 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.601 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for MYO10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO10 Gene

ENSEMBL:
Gene Tree for MYO10 (if available)
TreeFam:
Gene Tree for MYO10 (if available)

Paralogs for MYO10 Gene

Paralogs for MYO10 Gene

genes like me logo Genes that share paralogs with MYO10: view

Variants for MYO10 Gene

Sequence variations from dbSNP and Humsavar for MYO10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs17707947 - 16,877,635(+) GACGA(C/T)GATGC reference, missense
rs6870170 - 16,780,531(+) CTTTC(G/T)TCATG reference, missense
rs11750538 - 16,769,164(+) TTCCC(A/G)AACTT reference, missense
rs26740 - 16,710,978(+) TCCCT(C/T)GGACG reference, missense
rs25901 - 16,673,866(+) TCTCG(A/C/G)TTCCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MYO10 Gene

Variant ID Type Subtype PubMed ID
nsv522062 CNV Loss 19592680
nsv516145 CNV Loss 19592680
nsv4737 CNV Loss 18451855
esv2673450 CNV Deletion 23128226
nsv880373 CNV Gain 21882294
esv268284 CNV Insertion 20981092
esv274094 CNV Insertion 20981092
esv1009519 CNV Insertion 20482838
esv1329295 CNV Insertion 17803354
nsv520128 CNV Loss 19592680
nsv880277 CNV Gain 21882294
nsv461987 CNV Loss 19166990
dgv1014e199 CNV Deletion 23128226
esv2729841 CNV Deletion 23290073
esv29770 CNV Loss 19812545
esv2667787 CNV Deletion 23128226
nsv471739 CNV Loss 16327809
esv2676823 CNV Deletion 23128226
esv22694 CNV Loss 19812545
esv2729842 CNV Deletion 23290073

Variation tolerance for MYO10 Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.39; 98.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MYO10 Gene

Disorders for MYO10 Gene

Relevant External Links for MYO10

Genetic Association Database (GAD)
MYO10
Human Genome Epidemiology (HuGE) Navigator
MYO10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO10

No disorders were found for MYO10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYO10 Gene

Publications for MYO10 Gene

  1. Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin. (PMID: 10984435) Berg J.S. … Cheney R.E. (J. Cell Sci. 2000) 3 4 23 67
  2. The motor protein myosin-X transports VE-cadherin along filopodia to allow the formation of early endothelial cell-cell contacts. (PMID: 20123970) Almagro S. … Gulino-Debrac D. (Mol. Cell. Biol. 2010) 3 23
  3. Calmodulin-like protein upregulates myosin-10 in human keratinocytes and is regulated during epidermal wound healing in vivo. (PMID: 18818677) Bennett R.D. … Strehler E.E. (J. Invest. Dermatol. 2009) 3 23
  4. Calmodulin-like protein enhances myosin-10 translation. (PMID: 18295593) Bennett R.D. … Strehler E.E. (Biochem. Biophys. Res. Commun. 2008) 3 23
  5. Interaction with the IQ3 motif of myosin-10 is required for calmodulin-like protein-dependent filopodial extension. (PMID: 18570893) Bennett R.D. … Strehler E.E. (FEBS Lett. 2008) 3 23

Products for MYO10 Gene

Sources for MYO10 Gene

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