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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MYO10 Gene

protein-coding GIFtS: 60
GCID: GC05M016718

myosin X

Explore 1 disease affiliated with
MYO10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Myosin X¹ ²
KIAA0799¹ ³
Unconventional Myosin-10² ³
Myosin-X¹
Unconventional Myosin-X²
Unconventionnal Myosin-X²

External Ids:	HGNC: 7593¹	Entrez Gene: 4651²	Ensembl: ENSG00000145555⁷	OMIM: 601481⁵	UniProtKB: Q9HD67³

Export aliases for MYO10 gene to outside databases

Previous GC identifers: GC05M016655 GC05M016944 GC05M016698

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYO10:

This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be

confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of

conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an

actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis.

(provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: MYO10_HUMAN, Q9HD67

Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular

movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain

binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo

transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and

elongation of filopodia. May play a role in neurite outgrowth and axon guidance. Plays a role in formation of the

podosome belt in osteoclasts (By similarity)

Gene Wiki entry for MYO10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006576.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MYO10 gene promoter:
c-Fos AP-1 JunB Fra-1 FosB FOXD1 S8 JunD aMEF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MYO10 promoter sequence

Search SABiosciences Chromatin IP Primers for MYO10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYO10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.1-p14.3 Ensembl cytogenetic band: 5p15.1 HGNC cytogenetic band: 5p15.1-p14.3

MYO10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYO10 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M016718: view genomic region (about GC identifiers)

Start:	16,662,016 bp from pter	End:	16,936,385 bp from pter
Size:	274,370 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MYO10_HUMAN, Q9HD67 (See protein sequence)

Recommended Name: Unconventional myosin-X

Size: 2058 amino acids; 237347 Da

Subunit: Monomer, when in an inactive confomation in the cytosol. Homodimer in its active, membrane-bound conformation.

Interacts with CALM. Interacts with ECM29. Interacts with NEO1. Interacts with ITGB1 and ITGB3 (By similarity).

Interacts with DCC and ITGB5; the presence of DCC inhibits ITGB5 binding. Interacts with tubulin; ITGB5 or DCC binding

inhibits tubulin binding

Subcellular location: Cytoplasm, cytosol. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm,

cytoskeleton. Cell projection, filopodium tip. Cytoplasm, cell cortex. Cell projection, filopodium membrane;

Peripheral membrane protein (By similarity). Note=May be in an inactive, monomeric conformation in the cytosol.

Detected in cytoplasmic punctae and in cell projections. Colocalizes with actin fibers. Undergoes forward and rearward

movements within filopodia. Interacts with microtubules

Caution: Represents a unconventional myosin. This protein should not be confused with the conventional myosin-10

(MYH10)

Sequence caution: Sequence=BAA34519.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

4 PDB 3D structures from and Proteopedia for MYO10:

2LW9 (3D)

3AU4 (3D)

3AU5 (3D)

3PZD (3D)

Secondary accessions: A7E2D1 O94893 Q9NYM7 Q9P110 Q9P111 Q9UHF6

Explore the universe of human proteins at neXtProt for MYO10: NX_Q9HD67

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HD67

MYO10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_036466.2

ENSEMBL proteins:

ENSP00000421280 ENSP00000425051 ENSP00000421170 ENSP00000421309 ENSP00000426783

ENSP00000426664 ENSP00000274203 ENSP00000391106

Reactome Protein details: Q9HD67
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MYO10

Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	IEA	--
GO:0005730	nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	IEA	--
GO:0005886	plasma membrane	IDA	--

MYO10 for ontologies About GeneDecksing

MYO10 Antibody Products:

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Assay Products for MYO10:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MYO10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MYO10 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR019748 FERM_central

IPR000857 MyTH4_dom

IPR000048 IQ_motif_EF-hand-BS

IPR001849 Pleckstrin_homology

IPR019749 Band_41_domain

Graphical View of Domain Structure for InterPro Entry Q9HD67

ProtoNet protein and cluster: Q9HD67

3 Blocks protein families:

IPB000048 IQ calmodulin-binding region

IPB000857 Core domain in kinesin and myosin motor

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: MYO10_HUMAN, Q9HD67

Domain: Interaction between the motor domain and the tail leads to an inactive, monomeric conformation. Phospholipid

binding via the PH domains leads to the formation of the active, dimeric form of the protein and strongly increases

actin-dependent ATPase activity and motor activity (By similarity)

Domain: Interacts with membranes containing phosphatidylinositol-3,4,5-trisphosphate via the PH domains (By similarity)

Similarity: Contains 1 FERM domain

Similarity: Contains 3 IQ domains

Similarity: Contains 1 myosin head-like domain

Similarity: Contains 1 MyTH4 domain

Similarity: Contains 2 PH domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MYO10_HUMAN, Q9HD67

Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular

movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain

binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo

transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and

elongation of filopodia. May play a role in neurite outgrowth and axon guidance. Plays a role in formation of the

podosome belt in osteoclasts (By similarity)

Genatlas biochemistry entry for MYO10:

myosin X,unconventional,apparently non filamentous,homologous to mouse Myo10,and porcine myosin VIIB

miRNA Products:		miRTarBase miRNAs that target MYO10: hsa-mir-155 (MIRT001532), hsa-mir-30a (MIRT005212)

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		hsa-miR-140-5p hsa-miR-548j hsa-miR-199a-3p hsa-miR-218-1* hsa-miR-374a hsa-miR-29a* hsa-miR-548a-5p hsa-miR-130b

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO10

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003774	motor activity	--	--
GO:0005516	calmodulin binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0005543	phospholipid binding	--	--
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	ISS	--

MYO10 for ontologies About GeneDecksing

Animal Models:
1 MGI phenotypic allele

for Myo10 (no phenotypes)

MYO10 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PAK Pathway

	PAK Pathway	1.00			Epithelial Adherens Junctions	0.36
	Antioxidant Action of Vitamin-C	0.56

Immune System

Immune System

1.00

Innate Immune System

0.46

Regulation of actin dynamics for phagocytic cup formation

Regulation of actin dynamics for phagocytic cup formation

1.00

Fcgamma receptor (FCGR) dependent phagocytosis

0.80

Axon guidance

Axon guidance

1.00

Developmental Biology

0.69

Fc-GammaR-Mediated Phagocytosis in Macrophages

Fc-GammaR-Mediated Phagocytosis in Macrophages

1.00

RhoGDI Pathway

0.33

Pathway sources
See GeneCards unified pathways
Show all pathways

5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYO10 (see all 11)

	RhoA Pathway
	Antioxidant Action of Vitamin-C
	Transendothelial Migration of Leukocytes
	Actin Nucleation by ARP-WASP Complex
	Epithelial Adherens Junctions

5/7 Reactome Pathways for MYO10 (see all 7)

	Developmental Biology
	Netrin-1 signaling
	Regulation of actin dynamics for phagocytic cup formation
	Fcgamma receptor (FCGR) dependent phagocytosis
	Axon guidance

1 Kegg Pathway (Kegg details for MYO10):

Fc gamma R-mediated phagocytosis

MYO10 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MYO10

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/25 Interacting proteins for MYO10 (Q9HD67^{2, 3} ENSP00000391106⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 25)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DCC	P43146²^,³, ENSP00000389140⁴	MINT-8199123 MINT-8199598 MINT-8199637 MINT-8199109 MINT-8199139 MINT-8199557 MINT-8199615 MINT-8199775 I2D: score=1 STRING: ENSP00000389140
CALM2	P62158²^,³	MINT-6595938 MINT-6596013 I2D: score=3
ITGB5	P18084²^,³, ENSP00000296181⁴	MINT-8199775 MINT-8199748 I2D: score=3 STRING: ENSP00000296181
CALML3	P27482²^,³, ENSP00000315299⁴	MINT-6595901 MINT-6596000 I2D: score=2 STRING: ENSP00000315299
TUBB2B	Q9BVA1²^,³, ENSP00000259818⁴	MINT-8199713 I2D: score=1 STRING: ENSP00000259818

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007411	axon guidance	TAS	--
GO:0008360	regulation of cell shape	IMP	16894163
GO:0022409	positive regulation of cell-cell adhesion	IEA	--
GO:0030705	cytoskeleton-dependent intracellular transport	ISS	--
GO:0051489	regulation of filopodium assembly	IMP	16894163

MYO10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MYO10
Search CenterWatch for drugs/clinical trials and news about MYO10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MYO10 gene:

NM_012334.2

Unigene Cluster for MYO10:

Myosin X

Hs.481720 [show with all ESTs]

Unigene Representative Sequence: NM_012334

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000513610(uc011cnb.2 uc011cnc.2 uc011cnd.2 uc011cne.2 uc010itx.3 uc003jft.4 uc003jfu.2)

ENST00000515803 ENST00000505695 ENST00000513882 ENST00000506343 ENST00000512061

ENST00000510401 ENST00000508318 ENST00000511972 ENST00000502436 ENST00000507288(uc003jfv.2)

ENST00000274203 ENST00000427430

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		8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate MYO10 (see all 86):
		hsa-miR-140-5p hsa-miR-548j hsa-miR-199a-3p hsa-miR-218-1* hsa-miR-374a hsa-miR-29a* hsa-miR-548a-5p hsa-miR-130b

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Additional cDNA sequence:

AB018342.2 AF132021.1 AF132022.1 AF184153.1 AF234532.1 AF247457.2 AK001501.1 AK024719.1

AK025921.1 AK027764.1 AK074717.1 AK125246.1 AK295630.1 AK295736.1 AK303459.1 AK316138.1

AL832428.1 BC014956.1 BC032669.1 BC041694.1 BC050682.1 BC071965.1 BC094838.1 BC108736.1

BC137168.1 BC150285.1

24/25 DOTS entries (see all 25):

DT.453025 DT.120804177 DT.440413 DT.100042155 DT.100034484 DT.91901575 DT.105454 DT.439717

DT.95108967 DT.120804155 DT.120804227 DT.75146192 DT.97797041 DT.100042154 DT.120804152 DT.91770913

DT.100789920 DT.120804192 DT.91792263 DT.95108966 DT.100641566 DT.120833566 DT.424542 DT.95108971

24/319 AceView cDNA sequences (see all 319):

AI201299 AW069458 CD558889 T35509 BU684756 AI539831 T16435 AA486510

AI274926 AK024719 H98978 BQ711166 T33166 AL832428 BI522546 BU196588

BU624897 BQ897591 CD657170 BQ921359 AW118975 AW069392 N59341 BF223407

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MYO10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAAACTGTT

About this image

MYO10 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Spinal Dorsal Columns

Dorsal Spinal Cord Progenitor Cells

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Medulla Oblongata

Brain

Neural Tube

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Telencephalon

Neural Tube

Spinal Cord

Presumptive Spinal Cord

Spinal Cord

Spinal Dorsal Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

See MYO10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MYO10

SOURCE GeneReport for Unigene cluster: Hs.481720

UniProtKB/Swiss-Prot: MYO10_HUMAN, Q9HD67

Tissue specificity: Ubiquitous

SABiosciences Custom PCR Arrays for MYO10

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYO10

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYO10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MYO10 gene from 5/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Myo10^{1 , 5}	myosin X^{1, 5}	87.56(n)¹ 94.75(a)¹		15 (9.36 cM)⁵ 17909¹ NM_019472.2¹ NP_062345.2¹ 25622525⁵
chicken (Gallus gallus)	Aves	MYO10¹	myosin X	78.27(n) 87.74(a)		420913 XM_419000.3 XP_419000.3
lizard (Anolis carolinensis)	Reptilia	MYO10⁶	--	85(a)	1 ↔ 1	4(60009165-60141054)
African clawed frog (Xenopus laevis)	Amphibia	Xl.24147²	Xenopus laevis transcribed sequence with moderate similarity more	77.62(n)		BJ072146.1
zebrafish (Danio rerio)	Actinopterygii	wufc04d08²	Transcribed sequence with moderate similarity to protein more	74.54(n)		57045444

ENSEMBL Gene Tree for MYO10 (if available)
TreeFam Gene Tree for MYO10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MYO10 gene

MYO3A² MYO9A² MYO5C² MYO15A² MYO7A² MYO9B² MYO16² MYO5A²

MYO7B² MYO5B² MYO6² MYO3B²

18/40 SIMAP similar genes for MYO10 using alignment to 7 protein entries: MYO10_HUMAN (see all proteins) (see all similar genes):

DKFZp762A083 MYO15A MYO9B variant protein MYO1G MYH13 MYH3

MYO3A MYO5C MYH6 MYO1B MYO9A MYO6

MYO1C MYO1E MYO5A MYO7A MYH10 MYO1H

MYO10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11292604^1,2	C	--	16641308(+)	`TTTTC-/TTTTTT`	1	--	int¹ trp³		2		NA CSA	4
rs153202^1,2	C,F,O,A,H,	--	16661569(-)	`CTGGGC/TGCTCA`	1	--	ds500¹		24		EA NA NS WA	2972
rs142522811^1,2		--	16661738(+)	`AGATTA/CATGCA`	1	--	ds500¹		0	--	--	--	--
rs17501044^1,2	C,F,H,	--	16661843(+)	`TGCTTC/GTAAAG`	1	--	ds500¹		14		NA NS EA	1096
rs73755106^1,2	C,	--	16661862(+)	`CTTCCA/GTAATT`	1	--	ds500¹		2		WA	120
rs151111385^1,2		--	16661897(+)	`CTTTCC/TATGAA`	1	--	ds500¹		0	--	--	--	--
rs74958553^1,2	C,	--	16662019(+)	`GATCTG/ATTTCA`	1	--	ut3¹		1		NA	120
rs190785209^1,2		--	16662296(+)	`TAAAGC/GGCTTA`	1	--	ut3¹		0	--	--	--	--
rs13537^1,2	C,F,A,H,	--	16662297(-)	`ATAAGC/TGCTTT`	1	--	ut3¹		27		MN NS EA NA WA CSA	2859
rs153201^1,2	F,	--	16662303(-)	`ATAAAA/CATAAG`	1	--	ut3¹		1		EA	120

HapMap Linkage Disequilibrium report for MYO10 (16662016 - 16912016 bp, first 250kb of MYO10)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for MYO10
3 CNVs: 64134 51614 51616
4 Indels: 92903 80840 10899 64133

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MYO10 for disorders           About GeneDecksing

OMIM gene information: 601481    OMIM disorders: --

1 disease for MYO10:    About MalaCards

neuronitis

Human Genome Epidemiology (HuGE) Navigator: MYO10 (2 documents)

Export disorders for MYO10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MYO10 gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with MYO10)

Utopia: connect your pdf to the dynamic
world of online information

Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin. (PubMed id 10984435)^{1, 2, 9} Berg J.S.... Cheney R.E. (2000)
Myosin-X is a molecular motor that functions in filopodia formation. (PubMed id 16894163)^{1, 2, 9} Bohil A.B....Cheney R.E. (2006)
Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain. (PubMed id 21642953)^{1, 2} Hirano Y....Hakoshima T. (2011)
Cargo recognition mechanism of myosin X revealed by t he structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain. (PubMed id 21321230)^{1, 2} Wei Z....Zhang M. (2011)
A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PubMed id 20682791)^{1, 2} Gorbea C.... Rechsteiner M. (2010)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Physical map and characterization of transcripts in the candidate interval for familial chondrocalcinosis at chromosome 5p15.1. (PubMed id 10610710)^{1, 2} Rojas K.... Williams C.J. (1999)
Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)^{1, 2} Nagase T.... Ohara O. (1998)
Mapping of unconventional myosins in mouse and human. (PubMed id 8884266)^{1, 3} Hasson T.... Jenkins N.A. (1996)
Calmodulin-like protein enhances myosin-10 translation. (PubMed id 18295593)^{1, 9} Bennett R.D. and Strehler E.E. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4651	HGNC: 7593	AceView: MYO10	Ensembl:ENSG00000145555	euGenes: HUgn4651
ECgene: MYO10	Kegg: 4651	H-InvDB: MYO10

(According to HUGE)
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HUGE: KIAA0799

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MYO10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MYO10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MYO10 gene:
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GeneCards and IP:
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