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Aliases for MYO10 Gene

Aliases for MYO10 Gene

  • Myosin X 2 3 5
  • Unconventional Myosin-10 4
  • KIAA0799 4

External Ids for MYO10 Gene

Previous GeneCards Identifiers for MYO10 Gene

  • GC05M016655
  • GC05M016944
  • GC05M016698
  • GC05M016718

Summaries for MYO10 Gene

Entrez Gene Summary for MYO10 Gene

  • This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]

GeneCards Summary for MYO10 Gene

MYO10 (Myosin X) is a Protein Coding gene. Diseases associated with MYO10 include Chondrocalcinosis. Among its related pathways are Immune System and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include calmodulin binding and motor activity. An important paralog of this gene is MYO15A.

UniProtKB/Swiss-Prot for MYO10 Gene

  • Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts.

  • Isoform Headless: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity).

Gene Wiki entry for MYO10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYO10 Gene

Genomics for MYO10 Gene

Regulatory Elements for MYO10 Gene

Enhancers for MYO10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F016957 0.4 ENCODE 12 -21.7 -21675 1.6 JUND NFYB JUN BHLHE40 SMC3 FOS MYO10 GC05M016942 RNU6-660P GC05P017050
GH05F017189 0.7 Ensembl ENCODE 11.7 -254.6 -254615 3.2 SREBF2 KLF17 SIN3A ZNF2 RAD21 ZEB1 RFX5 GTF3C2 ZNF335 ZNF143 MYO10 LOC285696 BASP1 DCAF13P2 LOC105374664
GH05F017184 1.2 FANTOM5 Ensembl ENCODE 11.7 -250.1 -250074 3.9 CTCF ZNF121 ZNF366 BHLHE40 FOS PRDM1 NFE2L2 MYO10 BASP1 DCAF13P2 LOC105374664
GH05F016930 1 ENCODE 9.9 +2.1 2058 6.9 PKNOX1 SIN3A FEZF1 GLI4 BRCA1 ZNF2 ZNF121 GLIS2 ZNF143 KLF7 LINC02111 ENSG00000248223 ENSG00000249199 H3.X LOC391744 ENSG00000250667 NACAP6 MYO10 GC05P016917 GC05P016918
GH05F016912 1 Ensembl ENCODE 9.3 +22.5 22542 3.1 ZSCAN18 FEZF1 ZNF2 ZNF324 HIC1 ZFHX2 ZBTB48 ZNF19 SCRT2 KLF7 MYO10 GC05P016917 GC05P016918 RPS26P28
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MYO10 on UCSC Golden Path with GeneCards custom track

Promoters for MYO10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001276237 976 3401 SIN3A FEZF1 GLI4 ZNF2 ZNF121 GLIS2 ZNF143 KLF7 DEK ZNF263

Genomic Location for MYO10 Gene

Chromosome:
5
Start:
16,661,907 bp from pter
End:
16,936,276 bp from pter
Size:
274,370 bases
Orientation:
Minus strand

Genomic View for MYO10 Gene

Genes around MYO10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO10 Gene

Proteins for MYO10 Gene

  • Protein details for MYO10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD67-MYO10_HUMAN
    Recommended name:
    Unconventional myosin-X
    Protein Accession:
    Q9HD67
    Secondary Accessions:
    • A7E2D1
    • O94893
    • Q8IVX5
    • Q9NYM7
    • Q9P110
    • Q9P111
    • Q9UHF6

    Protein attributes for MYO10 Gene

    Size:
    2058 amino acids
    Molecular mass:
    237347 Da
    Quaternary structure:
    • Monomer, when in an inactive confomation in the cytosol. Homodimer in its active, membrane-bound conformation; antiparallel coiled coil-mediated dimer formation. Interacts strongly with CALM3 and weakly with CALM, the CALM3 interaction is essential for function in filopodial extension and motility. Interacts with ECM29. Interacts with NEO1. Interacts with ITGB1 and ITGB3. Interacts with VASP (By similarity). Interacts with DCC and ITGB5; the presence of DCC inhibits ITGB5 binding. Interacts with tubulin; ITGB5 or DCC binding inhibits tubulin binding.
    SequenceCaution:
    • Sequence=BAA34519.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MYO10 Gene

    Alternative splice isoforms for MYO10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYO10 Gene

Post-translational modifications for MYO10 Gene

No data available for DME Specific Peptides for MYO10 Gene

Domains & Families for MYO10 Gene

Suggested Antigen Peptide Sequences for MYO10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HD67

UniProtKB/Swiss-Prot:

MYO10_HUMAN :
  • Interaction between the motor domain and the tail leads to an inactive, monomeric conformation. Phospholipid binding via the PH domains leads to the formation of the active, dimeric form of the protein and strongly increases actin-dependent ATPase activity and motor activity (By similarity).
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • Interaction between the motor domain and the tail leads to an inactive, monomeric conformation. Phospholipid binding via the PH domains leads to the formation of the active, dimeric form of the protein and strongly increases actin-dependent ATPase activity and motor activity (By similarity).
  • Interacts with membranes containing phosphatidylinositol-3,4,5-trisphosphate via the PH domains.
  • IQ 3 domain mediates high-affinity calcium-dependent binding to CALM3/CLP.
  • The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha-helical structure by ionic bonds. It can refold after extension suggesting an in vivo force-dependent function. The isolated SAH domain is monomeric; however, in its distal part seems to form a semirigid helical structure which overlaps with a region shown to mediate antiparallel coiled coil-mediated dimerization.
  • Contains 1 FERM domain.
  • Contains 3 IQ domains.
  • Contains 1 myosin motor domain.
  • Contains 1 MyTH4 domain.
  • Contains 2 PH domains.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO10: view

Function for MYO10 Gene

Molecular function for MYO10 Gene

GENATLAS Biochemistry:
myosin X,unconventional,apparently non filamentous,homologous to mouse Myo10,and porcine myosin VIIB
UniProtKB/Swiss-Prot Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts.
UniProtKB/Swiss-Prot Function:
Isoform Headless: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity).

Gene Ontology (GO) - Molecular Function for MYO10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity EXP,IEA 12055636
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 18570893
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYO10: view
genes like me logo Genes that share phenotypes with MYO10: view

Animal Models for MYO10 Gene

MGI Knock Outs for MYO10:

Animal Model Products

miRNA for MYO10 Gene

miRTarBase miRNAs that target MYO10

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYO10 Gene

Localization for MYO10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO10 Gene

Cytoplasm, cytosol. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Cell projection, filopodium tip. Cytoplasm, cell cortex. Cell projection, filopodium membrane; Peripheral membrane protein. Note=May be in an inactive, monomeric conformation in the cytosol. Detected in cytoplasmic punctae and in cell projections. Colocalizes with actin fibers. Undergoes forward and rearward movements within filopodia. Interacts with microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYO10 Gene COMPARTMENTS Subcellular localization image for MYO10 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
cytoskeleton 4

Gene Ontology (GO) - Cellular Components for MYO10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with MYO10: view

Pathways & Interactions for MYO10 Gene

genes like me logo Genes that share pathways with MYO10: view

Gene Ontology (GO) - Biological Process for MYO10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007165 signal transduction IEA --
GO:0008360 regulation of cell shape IMP 16894163
GO:0022409 positive regulation of cell-cell adhesion IEA --
GO:0030705 cytoskeleton-dependent intracellular transport ISS --
genes like me logo Genes that share ontologies with MYO10: view

No data available for SIGNOR curated interactions for MYO10 Gene

Transcripts for MYO10 Gene

Unigene Clusters for MYO10 Gene

Myosin X:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYO10 Gene

No ASD Table

Relevant External Links for MYO10 Gene

GeneLoc Exon Structure for
MYO10
ECgene alternative splicing isoforms for
MYO10

Expression for MYO10 Gene

mRNA expression in normal human tissues for MYO10 Gene

Protein differential expression in normal tissues from HIPED for MYO10 Gene

This gene is overexpressed in Plasma (39.2), Pancreas (16.1), and Heart (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYO10 Gene



NURSA nuclear receptor signaling pathways regulating expression of MYO10 Gene:

MYO10

SOURCE GeneReport for Unigene cluster for MYO10 Gene:

Hs.481720

mRNA Expression by UniProt/SwissProt for MYO10 Gene:

Q9HD67-MYO10_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with MYO10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for MYO10 Gene

Orthologs for MYO10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYO10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYO10 34 35
  • 99.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MYO10 35
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYO10 34 35
  • 88.12 (n)
rat
(Rattus norvegicus)
Mammalia Myo10 34
  • 87.32 (n)
mouse
(Mus musculus)
Mammalia Myo10 34 16 35
  • 87.28 (n)
oppossum
(Monodelphis domestica)
Mammalia MYO10 35
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYO10 34 35
  • 86.9 (n)
chicken
(Gallus gallus)
Aves MYO10 34 35
  • 78.26 (n)
lizard
(Anolis carolinensis)
Reptilia MYO10 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20076 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24147 34
zebrafish
(Danio rerio)
Actinopterygii myo10 34 35
  • 66.48 (n)
wufc04d08 34
fruit fly
(Drosophila melanogaster)
Insecta d 36
  • 30 (a)
Myo10A 35
  • 18 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO2 35
  • 24 (a)
ManyToMany
MYO4 35
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.601 34
Species where no ortholog for MYO10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYO10 Gene

ENSEMBL:
Gene Tree for MYO10 (if available)
TreeFam:
Gene Tree for MYO10 (if available)

Paralogs for MYO10 Gene

Variants for MYO10 Gene

Sequence variations from dbSNP and Humsavar for MYO10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10035649 -- 16,889,092(+) ggctt(A/G)agccc intron-variant
rs10036312 -- 16,896,733(+) GCCCC(A/C)CCAGG intron-variant
rs10036590 -- 16,877,374(+) CATGC(C/T)CTTCT intron-variant
rs10037139 -- 16,793,484(+) GCGCC(C/T)GGCTG intron-variant
rs10037291 -- 16,742,933(+) CTGGA(C/G)AGCAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MYO10 Gene

Variant ID Type Subtype PubMed ID
dgv1014e199 CNV deletion 23128226
esv1009519 CNV insertion 20482838
esv1329295 CNV insertion 17803354
esv22694 CNV loss 19812545
esv2667787 CNV deletion 23128226
esv2673450 CNV deletion 23128226
esv2676823 CNV deletion 23128226
esv2729841 CNV deletion 23290073
esv2729842 CNV deletion 23290073
esv2762500 CNV gain 21179565
esv2763439 CNV loss 21179565
esv29770 CNV loss 19812545
esv3565584 CNV deletion 23714750
esv3570010 CNV loss 25503493
esv3604136 CNV loss 21293372
esv3604138 CNV loss 21293372
esv3604140 CNV loss 21293372
esv3604141 CNV loss 21293372
nsv1026773 CNV loss 25217958
nsv1034844 CNV loss 25217958
nsv1114655 CNV deletion 24896259
nsv1123916 CNV deletion 24896259
nsv1128145 CNV deletion 24896259
nsv461987 CNV loss 19166990
nsv471739 CNV loss 16327809
nsv472246 CNV novel sequence insertion 20440878
nsv4737 CNV deletion 18451855
nsv516145 CNV loss 19592680
nsv520128 CNV loss 19592680
nsv522062 CNV loss 19592680
nsv597309 CNV loss 21841781
nsv597310 CNV loss 21841781
nsv968877 CNV duplication 23825009

Variation tolerance for MYO10 Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.39; 98.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYO10 Gene

Human Gene Mutation Database (HGMD)
MYO10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYO10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO10 Gene

Disorders for MYO10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYO10 Gene - From: GeneCards

Disorder Aliases PubMed IDs
chondrocalcinosis
  • calcium pyrophosphate deposition disease
- elite association - COSMIC cancer census association via MalaCards
Search MYO10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYO10

Genetic Association Database (GAD)
MYO10
Human Genome Epidemiology (HuGE) Navigator
MYO10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYO10
genes like me logo Genes that share disorders with MYO10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYO10 Gene

Publications for MYO10 Gene

  1. Interaction with the IQ3 motif of myosin-10 is required for calmodulin-like protein-dependent filopodial extension. (PMID: 18570893) Bennett R.D. … Strehler E.E. (FEBS Lett. 2008) 3 4 22 64
  2. Myosin-X is a molecular motor that functions in filopodia formation. (PMID: 16894163) Bohil A.B. … Cheney R.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 22 64
  3. The tumor-sensitive calmodulin-like protein is a specific light chain of human unconventional myosin X. (PMID: 11278607) Rogers M.S. … Strehler E.E. (J. Biol. Chem. 2001) 3 4 22 64
  4. Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin. (PMID: 10984435) Berg J.S. … Cheney R.E. (J. Cell Sci. 2000) 3 4 22 64
  5. Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain. (PMID: 21321230) Wei Z. … Zhang M. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3 4 64

Products for MYO10 Gene

Sources for MYO10 Gene

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