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Aliases for MYNN Gene

Aliases for MYNN Gene

  • Myoneurin 2 3 3 5
  • Zinc Finger And BTB Domain-Containing Protein 31 3 4
  • ZBTB31 3 4
  • OSZF 3 4
  • Zinc Finger Protein With BTB/POZ Domain 3
  • SBBIZ1 3
  • ZNF902 3

External Ids for MYNN Gene

Previous GeneCards Identifiers for MYNN Gene

  • GC03P166758
  • GC03P170539
  • GC03P170892
  • GC03P170812
  • GC03P170973
  • GC03P169490
  • GC03P166860

Summaries for MYNN Gene

Entrez Gene Summary for MYNN Gene

  • This gene encodes a member of the BTB/POZ and zinc finger domain-containing protein family that are involved in the control of gene expression. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 14. [provided by RefSeq, Jun 2010]

GeneCards Summary for MYNN Gene

MYNN (Myoneurin) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZBTB49.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYNN Gene

Genomics for MYNN Gene

Regulatory Elements for MYNN Gene

Enhancers for MYNN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F169240 2.6 VISTA Ensembl ENCODE 4.2 -526.8 -526799 4.6 PKNOX1 INSM2 FEZF1 ZNF2 ZNF366 SCRT2 ZNF263 CEBPB OVOL3 ZEB2 SEC62-AS1 ENSG00000270096 MYNN LOC105374206 GC03M169131
GH03F170221 1.5 FANTOM5 ENCODE 3.5 +453.4 453375 2.8 HDGF PKNOX1 ARNT CREB3L1 SIN3A ZNF2 YY1 SLC30A9 CBX5 ZNF143 ENSG00000239628 ENSG00000270096 PRKCI SEC62-AS1 RPL22P1 GPR160 ENSG00000270135 MYNN PHC3 LRRIQ4
GH03F169768 1 ENCODE 0.8 -0.1 -135 1.4 PKNOX1 SIN3A GLI4 DMAP1 ZNF48 BRCA1 ZNF2 YY1 GTF3C2 GLIS2 SEC62-AS1 LRRC34 ENSG00000269889 GC03M169768 MYNN
GH03F169784 0.3 FANTOM5 1.6 +15.3 15349 0.2 LRRC34 LRRIQ4 MYNN GPR160 ENSG00000269984 ENSG00000270135
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYNN on UCSC Golden Path with GeneCards custom track

Promoters for MYNN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001378965 51 1000 PKNOX1 SIN3A GLI4 DMAP1 ZNF48 BRCA1 ZNF2 YY1 GTF3C2 GLIS2

Genomic Location for MYNN Gene

Chromosome:
3
Start:
169,769,649 bp from pter
End:
169,789,716 bp from pter
Size:
20,068 bases
Orientation:
Plus strand

Genomic View for MYNN Gene

Genes around MYNN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYNN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYNN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYNN Gene

Proteins for MYNN Gene

  • Protein details for MYNN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPC7-MYNN_HUMAN
    Recommended name:
    Myoneurin
    Protein Accession:
    Q9NPC7
    Secondary Accessions:
    • B2R6C9
    • Q6QHA6
    • Q6QHA7
    • Q6R3G1
    • Q6R3G2
    • Q6R4A0
    • Q7Z716
    • Q7Z717
    • Q86Z11
    • Q86Z12
    • Q9NS01
    • Q9UIW8

    Protein attributes for MYNN Gene

    Size:
    610 amino acids
    Molecular mass:
    68682 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MYNN Gene

    Alternative splice isoforms for MYNN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYNN Gene

Post-translational modifications for MYNN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYNN Gene

Domains & Families for MYNN Gene

Gene Families for MYNN Gene

Graphical View of Domain Structure for InterPro Entry

Q9NPC7

UniProtKB/Swiss-Prot:

MYNN_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with MYNN: view

Function for MYNN Gene

Gene Ontology (GO) - Molecular Function for MYNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 10873615
GO:0008270 zinc ion binding TAS 10873615
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MYNN: view
genes like me logo Genes that share phenotypes with MYNN: view

Animal Model Products

miRNA for MYNN Gene

miRTarBase miRNAs that target MYNN

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYNN Gene

Localization for MYNN Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYNN Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYNN gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MYNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with MYNN: view

Pathways & Interactions for MYNN Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA,TAS --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MYNN: view

No data available for Pathways by source and SIGNOR curated interactions for MYNN Gene

Transcripts for MYNN Gene

Unigene Clusters for MYNN Gene

Myoneurin:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYNN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d ·
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5:
SP6: - - -
SP7: - - -
SP8: - - -
SP9: - -
SP10:
SP11: - - - - -
SP12: - -

ExUns: 12e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for MYNN Gene

GeneLoc Exon Structure for
MYNN
ECgene alternative splicing isoforms for
MYNN

Expression for MYNN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYNN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYNN Gene



Protein tissue co-expression partners for MYNN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MYNN Gene:

MYNN

SOURCE GeneReport for Unigene cluster for MYNN Gene:

Hs.507025

mRNA Expression by UniProt/SwissProt for MYNN Gene:

Q9NPC7-MYNN_HUMAN
Tissue specificity: Mainly expressed in the neuromuscular system. Located in and around synaptic myonuclei in adult muscle. Expression is dysregulated after nerve injury. Also found in the testis, ovary and placenta.
genes like me logo Genes that share expression patterns with MYNN: view

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for MYNN Gene

Orthologs for MYNN Gene

This gene was present in the common ancestor of animals.

Orthologs for MYNN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYNN 34 35
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia MYNN 34 35
  • 94.37 (n)
cow
(Bos Taurus)
Mammalia MYNN 34 35
  • 92.25 (n)
mouse
(Mus musculus)
Mammalia Mynn 34 16 35
  • 87.92 (n)
rat
(Rattus norvegicus)
Mammalia Mynn 34
  • 86.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MYNN 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYNN 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYNN 34 35
  • 77.21 (n)
lizard
(Anolis carolinensis)
Reptilia MYNN 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492148 34
  • 66.33 (n)
zebrafish
(Danio rerio)
Actinopterygii mynn 35
  • 29 (a)
OneToOne
-- 34
fruit fly
(Drosophila melanogaster)
Insecta CG1602 36
  • 36 (a)
rgr 36
  • 35 (a)
Species where no ortholog for MYNN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYNN Gene

ENSEMBL:
Gene Tree for MYNN (if available)
TreeFam:
Gene Tree for MYNN (if available)

Paralogs for MYNN Gene

Paralogs for MYNN Gene

(378) SIMAP similar genes for MYNN Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for MYNN Gene

genes like me logo Genes that share paralogs with MYNN: view

Variants for MYNN Gene

Sequence variations from dbSNP and Humsavar for MYNN Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10576565 -- 169,775,366(+) AAAGC(-/AA)AGAGA intron-variant
rs10681957 -- 169,776,695(+) TTTTT(-/TTT)TTGAG intron-variant
rs10936599 -- 169,774,313(+) CACCA(C/T)TGTGA nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime
rs111215366 -- 169,770,637(+) ATATA(A/G)AAATT upstream-variant-2KB
rs111215425 -- 169,770,696(+) AAAAT(A/T)TATAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MYNN Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER inversion 18451855
esv2422204 CNV deletion 17116639

Variation tolerance for MYNN Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYNN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYNN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYNN Gene

Disorders for MYNN Gene

Relevant External Links for MYNN

Genetic Association Database (GAD)
MYNN
Human Genome Epidemiology (HuGE) Navigator
MYNN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYNN

No disorders were found for MYNN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYNN Gene

Publications for MYNN Gene

  1. Myoneurin, a novel member of the BTB/POZ-zinc finger family highly expressed in human muscle. (PMID: 10873615) Alliel P.M. … Perin J.-P. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 22 64
  2. Neuromuscular expression of the BTB/POZ and zinc finger protein myoneurin. (PMID: 14694499) Cifuentes-Diaz C. … Alliel P.M. (Muscle Nerve 2004) 3 4 22 64
  3. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3 46 64
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  5. Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois P.C. … van Heel D.A. (Nat. Genet. 2010) 3 46 64

Products for MYNN Gene

Sources for MYNN Gene

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