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Aliases for MYLPF Gene

Aliases for MYLPF Gene

  • Myosin Light Chain, Phosphorylatable, Fast Skeletal Muscle 2 3 5
  • Fast Skeletal Myosin Light Chain 2 3 4
  • MLC2B 3 4
  • Myosin, Light Chain 11, Regulatory 3
  • Myosin Regulatory Light Chain 2 2
  • Myosin Light Chain 2 3
  • Light Chain 11 2
  • Regulatory 2
  • HUMMLC2B 3
  • Myosin 2
  • MRLC2 3
  • MYL11 3

External Ids for MYLPF Gene

Previous GeneCards Identifiers for MYLPF Gene

  • GC16P030294
  • GC16P030297
  • GC16P030387
  • GC16P027947

Summaries for MYLPF Gene

GeneCards Summary for MYLPF Gene

MYLPF (Myosin Light Chain, Phosphorylatable, Fast Skeletal Muscle) is a Protein Coding gene. Among its related pathways are Cardiac conduction and ErbB1 downstream signaling. GO annotations related to this gene include calcium ion binding and structural constituent of muscle. An important paralog of this gene is MYL2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYLPF Gene

Genomics for MYLPF Gene

Regulatory Elements for MYLPF Gene

Promoters for MYLPF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MYLPF on UCSC Golden Path with GeneCards custom track

Genomic Location for MYLPF Gene

Chromosome:
16
Start:
30,370,934 bp from pter
End:
30,377,991 bp from pter
Size:
7,058 bases
Orientation:
Plus strand

Genomic View for MYLPF Gene

Genes around MYLPF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYLPF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYLPF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYLPF Gene

Proteins for MYLPF Gene

  • Protein details for MYLPF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A32-MLRS_HUMAN
    Recommended name:
    Myosin regulatory light chain 2, skeletal muscle isoform
    Protein Accession:
    Q96A32
    Secondary Accessions:
    • B2RA83
    • Q14843
    • Q6IB41

    Protein attributes for MYLPF Gene

    Size:
    169 amino acids
    Molecular mass:
    19015 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains.
    Miscellaneous:
    • This chain binds calcium.

neXtProt entry for MYLPF Gene

Proteomics data for MYLPF Gene at MOPED

Post-translational modifications for MYLPF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYLPF Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MYLPF

No data available for DME Specific Peptides for MYLPF Gene

Domains & Families for MYLPF Gene

Gene Families for MYLPF Gene

Protein Domains for MYLPF Gene

Suggested Antigen Peptide Sequences for MYLPF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A32

UniProtKB/Swiss-Prot:

MLRS_HUMAN :
  • Contains 3 EF-hand domains.
Domain:
  • Contains 3 EF-hand domains.
genes like me logo Genes that share domains with MYLPF: view

Function for MYLPF Gene

genes like me logo Genes that share phenotypes with MYLPF: view

Animal Models for MYLPF Gene

MGI Knock Outs for MYLPF:

Animal Model Products

miRNA for MYLPF Gene

miRTarBase miRNAs that target MYLPF

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYLPF Gene

Localization for MYLPF Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYLPF Gene COMPARTMENTS Subcellular localization image for MYLPF gene
Compartment Confidence
cytoskeleton 5
cytosol 5
lysosome 5
vacuole 5
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for MYLPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
genes like me logo Genes that share ontologies with MYLPF: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYLPF Gene

Pathways & Interactions for MYLPF Gene

genes like me logo Genes that share pathways with MYLPF: view

Gene Ontology (GO) - Biological Process for MYLPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
GO:0007519 skeletal muscle tissue development IEA,ISS --
genes like me logo Genes that share ontologies with MYLPF: view

No data available for SIGNOR curated interactions for MYLPF Gene

Drugs & Compounds for MYLPF Gene

(1) Drugs for MYLPF Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with MYLPF: view

Transcripts for MYLPF Gene

mRNA/cDNA for MYLPF Gene

Unigene Clusters for MYLPF Gene

Myosin light chain, phosphorylatable, fast skeletal muscle:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYLPF Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1:
SP2: -
SP3: -
SP4:

Relevant External Links for MYLPF Gene

GeneLoc Exon Structure for
MYLPF
ECgene alternative splicing isoforms for
MYLPF

Expression for MYLPF Gene

mRNA expression in normal human tissues for MYLPF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYLPF Gene

This gene is overexpressed in Muscle - Skeletal (x51.8).

Protein differential expression in normal tissues from HIPED for MYLPF Gene

This gene is overexpressed in Esophagus (20.4), Kidney (16.8), Tonsil (16.3), and Stomach (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYLPF Gene



SOURCE GeneReport for Unigene cluster for MYLPF Gene Hs.50889

mRNA Expression by UniProt/SwissProt for MYLPF Gene

Q96A32-MLRS_HUMAN
Tissue specificity: Expressed in fetal and adult skeletal muscle.
genes like me logo Genes that share expression patterns with MYLPF: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for MYLPF Gene

Orthologs for MYLPF Gene

This gene was present in the common ancestor of animals.

Orthologs for MYLPF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYLPF 35
  • 91.52 (n)
  • 97.63 (a)
MYLPF 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYLPF 35
  • 92.5 (n)
  • 95.86 (a)
MYLPF 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mylpf 35
  • 88.76 (n)
  • 95.86 (a)
Mylpf 16
Mylpf 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mylpf 35
  • 87.77 (n)
  • 95.86 (a)
oppossum
(Monodelphis domestica)
Mammalia MYLPF 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYLPF 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYLPF 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYLPF 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75669 35
mylpf 35
  • 81.26 (n)
  • 89.35 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6263 35
zebrafish
(Danio rerio)
Actinopterygii mylpfb 35
  • 75.74 (n)
  • 81.66 (a)
mylz2 35
mylpfa 36
  • 81 (a)
OneToMany
mylpfb 36
  • 81 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9038 35
worm
(Caenorhabditis elegans)
Secernentea mlc-2 35
  • 58.7 (n)
  • 50.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10194 36
  • 53 (a)
ManyToMany
CSA.11077 36
  • 54 (a)
ManyToMany
Species with no ortholog for MYLPF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYLPF Gene

ENSEMBL:
Gene Tree for MYLPF (if available)
TreeFam:
Gene Tree for MYLPF (if available)

Paralogs for MYLPF Gene

Paralogs for MYLPF Gene

(11) SIMAP similar genes for MYLPF Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MYLPF: view

Variants for MYLPF Gene

Sequence variations from dbSNP and Humsavar for MYLPF Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs8046445 -- 30,374,941(+) TGGTT(C/T)CCAGT intron-variant
rs8050812 -- 30,374,516(+) CAGAA(C/T)GATGC upstream-variant-2KB
rs11863150 -- 30,374,182(+) GCTTC(A/G)TGGCA upstream-variant-2KB
rs28365888 -- 30,374,632(+) CTCCC(C/T)CCTTC upstream-variant-2KB
rs34837744 -- 30,374,249(-) AACCT(-/C)CCACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MYLPF Gene

Variant ID Type Subtype PubMed ID
nsv905724 CNV Loss 21882294
nsv827612 CNV Gain 20364138
nsv905725 CNV Loss 21882294

Variation tolerance for MYLPF Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYLPF Gene

HapMap Linkage Disequilibrium report
MYLPF
Human Gene Mutation Database (HGMD)
MYLPF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYLPF Gene

Disorders for MYLPF Gene

Relevant External Links for MYLPF

Genetic Association Database (GAD)
MYLPF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYLPF

No disorders were found for MYLPF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYLPF Gene

Publications for MYLPF Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Cloning and characterization of cDNA sequences corresponding to myosin light chains 1, 2, and 3, troponin-C, troponin-T, alpha-tropomyosin, and alpha-actin. (PMID: 6179945) Garfinkel L.I. … Nadal-Ginard B. (J. Biol. Chem. 1982) 2 3
  3. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  4. Identification of DeltaNp63alpha protein interactions by mass spectrometry. (PMID: 20085233) Amoresano A. … CalabrA^ V. (J. Proteome Res. 2010) 3
  5. An integrated workflow for charting the human interaction proteome: insights into the PP2A system. (PMID: 19156129) Glatter T. … Gstaiger M. (Mol. Syst. Biol. 2009) 3

Products for MYLPF Gene

Sources for MYLPF Gene

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