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Aliases for MYLK4 Gene

Aliases for MYLK4 Gene

  • Myosin Light Chain Kinase Family Member 4 2 3 5
  • Sugen Kinase 85 3 4
  • CaMLCK Like 2 3
  • EC 2.7.11.1 4 61
  • SgK085 3 4
  • Myosin Light Chain Kinase Family, Member 4 2
  • EC 2.7.11 61

External Ids for MYLK4 Gene

Previous GeneCards Identifiers for MYLK4 Gene

  • GC06M002613

Summaries for MYLK4 Gene

GeneCards Summary for MYLK4 Gene

MYLK4 (Myosin Light Chain Kinase Family Member 4) is a Protein Coding gene. Among its related pathways are Oxytocin signaling pathway and Salivary secretion. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MYLK3.

Tocris Summary for MYLK4 Gene

  • Myosin Light Chain Kinases (MLCKs) are a group of protein serine/threonine kinases that are currently divided into two subtypes. MLCK1 is found in smooth muscle and phosphorylates myosin II regulatory light chains at Ser19. MLCK2 is located in the striated muscle.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYLK4 Gene

Genomics for MYLK4 Gene

Regulatory Elements for MYLK4 Gene

Enhancers for MYLK4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F002688 1.2 Ensembl ENCODE 25.4 +81.5 81484 1.2 SMARCC1 JUN CEBPB EP300 FOSL1 CTBP1 JUND ATF3 FOS MYC MYLK4 LINC01600 LOC105374885 LOC105379664 GC06M002670
GH06F002732 1.8 FANTOM5 Ensembl ENCODE 19 +36.3 36323 2.8 TBP HDAC1 ATF1 TBL1XR1 CREB3L1 ZNF766 CREM CBFB ZBTB11 USF2 MYLK4 SERPINB9 WRNIP1 ENSG00000272277 PSMG4 SERPINB1 NQO2 RIPK1 GC06P002732 GC06P002738
GH06F002725 0.8 FANTOM5 Ensembl ENCODE 18.3 +43.5 43529 1.7 YBX3 TBP NFRKB ZNF766 GATA2 ZNF366 SIRT6 SMARCA5 ZEB2 ELF1 MYLK4 WRNIP1 RIPK1 SERPINB9 SERPINB1 NQO2 GC06P002732 GC06P002711
GH06F002713 1.3 Ensembl ENCODE 17.6 +54.4 54353 4.2 CTCF TBP SAP130 JUN BACH1 SIN3A ZNF384 FOSL1 POLR2A HNF4G WRNIP1 MYLK4 GC06P002711 GC06P002732
GH06F002788 1 FANTOM5 Ensembl ENCODE 16.9 -24.7 -24725 12.0 ATF1 PKNOX1 ARID4B DMAP1 ZNF48 GATA2 ZNF143 FOS DEK ZNF263 SERPINB9 SERPINB1 MYLK4 NQO2 WRNIP1 ENSG00000232999 LINC01011 SERPINB6 RIPK1 GC06P002811
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MYLK4 on UCSC Golden Path with GeneCards custom track

Promoters for MYLK4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001877504 1623 601 PKNOX1 ZNF692 ZBTB11 SIN3A ZNF600 ZNF423

Genomic Location for MYLK4 Gene

Chromosome:
6
Start:
2,663,629 bp from pter
End:
2,770,123 bp from pter
Size:
106,495 bases
Orientation:
Minus strand

Genomic View for MYLK4 Gene

Genes around MYLK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYLK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYLK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYLK4 Gene

Proteins for MYLK4 Gene

  • Protein details for MYLK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YV6-MYLK4_HUMAN
    Recommended name:
    Myosin light chain kinase family member 4
    Protein Accession:
    Q86YV6
    Secondary Accessions:
    • A2RUC0
    • Q5TAW2

    Protein attributes for MYLK4 Gene

    Size:
    388 amino acids
    Molecular mass:
    44508 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MYLK4 Gene

    Alternative splice isoforms for MYLK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYLK4 Gene

Selected DME Specific Peptides for MYLK4 Gene

Q86YV6:
  • NLIQLYDAFESK
  • GGELFDRII
  • GGELFDR
  • EKLKVNFGTPEFL
  • IIDFGLA
  • LHLDLKP
  • DMWSVGVI

Post-translational modifications for MYLK4 Gene

No Post-translational modifications

Other Protein References for MYLK4 Gene

Domains & Families for MYLK4 Gene

Gene Families for MYLK4 Gene

Suggested Antigen Peptide Sequences for MYLK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YV6

UniProtKB/Swiss-Prot:

MYLK4_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MYLK4: view

Function for MYLK4 Gene

Molecular function for MYLK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for MYLK4 Gene

Gene Ontology (GO) - Molecular Function for MYLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004687 myosin light chain kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with MYLK4: view
genes like me logo Genes that share phenotypes with MYLK4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MYLK4

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYLK4 Gene

Localization for MYLK4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYLK4 Gene COMPARTMENTS Subcellular localization image for MYLK4 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MYLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MYLK4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYLK4 Gene

Pathways & Interactions for MYLK4 Gene

genes like me logo Genes that share pathways with MYLK4: view

Gene Ontology (GO) - Biological Process for MYLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA --
GO:0018107 peptidyl-threonine phosphorylation IBA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with MYLK4: view

No data available for SIGNOR curated interactions for MYLK4 Gene

Drugs & Compounds for MYLK4 Gene

(4) Drugs for MYLK4 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
ML 9 hydrochloride Pharma Myosin light chain kinase inhibitor 0
ML-7 hydrochloride Pharma Myosin light chain kinase inhibitor, Selective inhibitor of myosin light chain kinase 0
MLCK inhibitor peptide 18 Pharma Selective inhibitor of myosin light chain kinase 0

(1) Additional Compounds for MYLK4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(3) Tocris Compounds for MYLK4 Gene

Compound Action Cas Number
ML 7 hydrochloride Selective inhibitor of myosin light chain kinase 110448-33-4
ML 9 hydrochloride Myosin light chain kinase inhibitor 105637-50-1
MLCK inhibitor peptide 18 Selective inhibitor of myosin light chain kinase 224579-74-2
genes like me logo Genes that share compounds with MYLK4: view

Transcripts for MYLK4 Gene

mRNA/cDNA for MYLK4 Gene

(7) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYLK4 Gene

Myosin light chain kinase family, member 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MYLK4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYLK4 Gene

No ASD Table

Relevant External Links for MYLK4 Gene

GeneLoc Exon Structure for
MYLK4
ECgene alternative splicing isoforms for
MYLK4

Expression for MYLK4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYLK4 Gene

mRNA differential expression in normal tissues according to GTEx for MYLK4 Gene

This gene is overexpressed in Muscle - Skeletal (x13.5).

Protein differential expression in normal tissues from HIPED for MYLK4 Gene

This gene is overexpressed in Heart (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYLK4 Gene



Protein tissue co-expression partners for MYLK4 Gene

NURSA nuclear receptor signaling pathways regulating expression of MYLK4 Gene:

MYLK4

SOURCE GeneReport for Unigene cluster for MYLK4 Gene:

Hs.127830
genes like me logo Genes that share expression patterns with MYLK4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MYLK4 Gene

Orthologs for MYLK4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYLK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYLK4 34 35
  • 99.4 (n)
dog
(Canis familiaris)
Mammalia MYLK4 34 35
  • 88.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MYLK4 35
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mylk4 34
  • 84.89 (n)
cow
(Bos Taurus)
Mammalia MYLK4 34 35
  • 84.48 (n)
mouse
(Mus musculus)
Mammalia Mylk4 34 16 35
  • 84.08 (n)
oppossum
(Monodelphis domestica)
Mammalia MYLK4 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYLK4 34 35
  • 77.26 (n)
lizard
(Anolis carolinensis)
Reptilia MYLK4 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497991 34
  • 70.78 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2372 34
zebrafish
(Danio rerio)
Actinopterygii LOC566845 34
  • 70.92 (n)
mylk4b 35
  • 32 (a)
OneToMany
mylk4a 35
  • 30 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sqa 35
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZC373.4 35
  • 12 (a)
OneToMany
Species where no ortholog for MYLK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYLK4 Gene

ENSEMBL:
Gene Tree for MYLK4 (if available)
TreeFam:
Gene Tree for MYLK4 (if available)

Paralogs for MYLK4 Gene

Variants for MYLK4 Gene

Sequence variations from dbSNP and Humsavar for MYLK4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs762093504 A breast infiltrating ductal carcinoma sample 2,692,787(+) ACCTG(A/C/T)GAGGG nc-transcript-variant, reference, missense
VAR_040864 A breast infiltrating ductal carcinoma sample
VAR_040868 A lung squamous cell carcinoma sample
rs796052168 Likely benign 2,685,390(-) AGAAC(A/G)AGATC nc-transcript-variant, reference, missense
rs1002910 -- 2,721,574(+) GCATG(C/T)ATCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYLK4 Gene

Variant ID Type Subtype PubMed ID
esv1778065 CNV insertion 17803354
esv2434989 CNV insertion 19546169
esv2731465 CNV deletion 23290073
esv2731466 CNV deletion 23290073
esv274995 CNV loss 21479260
esv3570726 CNV loss 25503493
esv3570727 CNV loss 25503493
esv3570728 CNV loss 25503493
esv3570729 CNV loss 25503493
esv3607900 CNV gain 21293372
esv3607912 CNV gain 21293372
nsv1131934 CNV deletion 24896259
nsv474757 CNV novel sequence insertion 20440878
nsv521426 CNV loss 19592680
nsv830574 CNV gain 17160897

Variation tolerance for MYLK4 Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.17; 87.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYLK4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYLK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYLK4 Gene

Disorders for MYLK4 Gene

Relevant External Links for MYLK4

Genetic Association Database (GAD)
MYLK4
Human Genome Epidemiology (HuGE) Navigator
MYLK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYLK4

No disorders were found for MYLK4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYLK4 Gene

Publications for MYLK4 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  3. The protein kinase complement of the human genome. (PMID: 12471243) Manning G. … Sudarsanam S. (Science 2002) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3 64

Products for MYLK4 Gene

Sources for MYLK4 Gene

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