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Aliases for MYLK4 Gene

Aliases for MYLK4 Gene

  • Myosin Light Chain Kinase Family Member 4 2 3 5
  • Sugen Kinase 85 3 4
  • CaMLCK Like 2 3
  • EC 2.7.11.1 4 61
  • SgK085 3 4
  • Myosin Light Chain Kinase Family, Member 4 2
  • EC 2.7.11 61

External Ids for MYLK4 Gene

Previous GeneCards Identifiers for MYLK4 Gene

  • GC06M002613

Summaries for MYLK4 Gene

GeneCards Summary for MYLK4 Gene

MYLK4 (Myosin Light Chain Kinase Family Member 4) is a Protein Coding gene. Among its related pathways are Focal Adhesion and Salivary secretion. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MYLK3.

Tocris Summary for MYLK4 Gene

  • Myosin Light Chain Kinases (MLCKs) are a group of protein serine/threonine kinases that are currently divided into two subtypes. MLCK1 is found in smooth muscle and phosphorylates myosin II regulatory light chains at Ser19. MLCK2 is located in the striated muscle.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYLK4 Gene

Genomics for MYLK4 Gene

Regulatory Elements for MYLK4 Gene

Enhancers for MYLK4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MYLK4 on UCSC Golden Path with GeneCards custom track

Promoters for MYLK4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MYLK4 on UCSC Golden Path with GeneCards custom track

Genomic Location for MYLK4 Gene

Chromosome:
6
Start:
2,663,629 bp from pter
End:
2,770,123 bp from pter
Size:
106,495 bases
Orientation:
Minus strand

Genomic View for MYLK4 Gene

Genes around MYLK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYLK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYLK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYLK4 Gene

Proteins for MYLK4 Gene

  • Protein details for MYLK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YV6-MYLK4_HUMAN
    Recommended name:
    Myosin light chain kinase family member 4
    Protein Accession:
    Q86YV6
    Secondary Accessions:
    • A2RUC0
    • Q5TAW2

    Protein attributes for MYLK4 Gene

    Size:
    388 amino acids
    Molecular mass:
    44508 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MYLK4 Gene

    Alternative splice isoforms for MYLK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYLK4 Gene

Selected DME Specific Peptides for MYLK4 Gene

Post-translational modifications for MYLK4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYLK4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MYLK4 Gene

Gene Families for MYLK4 Gene

Suggested Antigen Peptide Sequences for MYLK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YV6

UniProtKB/Swiss-Prot:

MYLK4_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MYLK4: view

Function for MYLK4 Gene

Molecular function for MYLK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for MYLK4 Gene

Gene Ontology (GO) - Molecular Function for MYLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYLK4: view
genes like me logo Genes that share phenotypes with MYLK4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MYLK4

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYLK4 Gene

Localization for MYLK4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYLK4 Gene COMPARTMENTS Subcellular localization image for MYLK4 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MYLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MYLK4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYLK4 Gene

Pathways & Interactions for MYLK4 Gene

genes like me logo Genes that share pathways with MYLK4: view

Gene Ontology (GO) - Biological Process for MYLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with MYLK4: view

No data available for SIGNOR curated interactions for MYLK4 Gene

Drugs & Compounds for MYLK4 Gene

(4) Drugs for MYLK4 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
ML 9 hydrochloride Pharma Myosin light chain kinase inhibitor 0
ML-7 hydrochloride Pharma Myosin light chain kinase inhibitor, Selective inhibitor of myosin light chain kinase 0
MLCK inhibitor peptide 18 Pharma Selective inhibitor of myosin light chain kinase 0

(1) Additional Compounds for MYLK4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(3) Tocris Compounds for MYLK4 Gene

Compound Action Cas Number
ML 7 hydrochloride Selective inhibitor of myosin light chain kinase 110448-33-4
ML 9 hydrochloride Myosin light chain kinase inhibitor 105637-50-1
MLCK inhibitor peptide 18 Selective inhibitor of myosin light chain kinase 224579-74-2
genes like me logo Genes that share compounds with MYLK4: view

Transcripts for MYLK4 Gene

mRNA/cDNA for MYLK4 Gene

(6) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYLK4 Gene

Myosin light chain kinase family, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MYLK4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYLK4 Gene

No ASD Table

Relevant External Links for MYLK4 Gene

GeneLoc Exon Structure for
MYLK4
ECgene alternative splicing isoforms for
MYLK4

Expression for MYLK4 Gene

mRNA expression in normal human tissues for MYLK4 Gene

mRNA differential expression in normal tissues according to GTEx for MYLK4 Gene

This gene is overexpressed in Muscle - Skeletal (x13.5).

Protein differential expression in normal tissues from HIPED for MYLK4 Gene

This gene is overexpressed in Heart (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYLK4 Gene



Protein tissue co-expression partners for MYLK4 Gene

NURSA nuclear receptor signaling pathways regulating expression of MYLK4 Gene:

MYLK4

SOURCE GeneReport for Unigene cluster for MYLK4 Gene:

Hs.127830
genes like me logo Genes that share expression patterns with MYLK4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MYLK4 Gene

Orthologs for MYLK4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYLK4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYLK4 34
  • 84.48 (n)
  • 84.85 (a)
MYLK4 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYLK4 34
  • 88.54 (n)
  • 88.89 (a)
MYLK4 35
  • 50 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mylk4 34
  • 84.08 (n)
  • 86.81 (a)
Mylk4 16
Mylk4 35
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYLK4 34
  • 99.4 (n)
  • 99.23 (a)
MYLK4 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mylk4 34
  • 84.89 (n)
  • 88.75 (a)
oppossum
(Monodelphis domestica)
Mammalia MYLK4 35
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYLK4 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYLK4 34
  • 77.26 (n)
  • 82.78 (a)
MYLK4 35
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYLK4 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497991 34
  • 70.78 (n)
  • 76.71 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2372 34
zebrafish
(Danio rerio)
Actinopterygii LOC566845 34
  • 70.92 (n)
  • 71.81 (a)
mylk4a 35
  • 30 (a)
OneToMany
mylk4b 35
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sqa 35
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZC373.4 35
  • 12 (a)
OneToMany
Species where no ortholog for MYLK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYLK4 Gene

ENSEMBL:
Gene Tree for MYLK4 (if available)
TreeFam:
Gene Tree for MYLK4 (if available)

Paralogs for MYLK4 Gene

Paralogs for MYLK4 Gene

genes like me logo Genes that share paralogs with MYLK4: view

Variants for MYLK4 Gene

Sequence variations from dbSNP and Humsavar for MYLK4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_040864 A breast infiltrating ductal carcinoma sample
rs2296356 - 2,749,147(-) GATCT(A/G)GACAT nc-transcript-variant, reference, missense
rs762093504 A breast infiltrating ductal carcinoma sample 2,692,787(+) ACCTG(A/C/T)GAGGG nc-transcript-variant, reference, missense
rs34953021 - 2,685,541(+) TGGCC(A/C/G)TCTCC nc-transcript-variant, reference, missense
VAR_040868 A lung squamous cell carcinoma sample

Structural Variations from Database of Genomic Variants (DGV) for MYLK4 Gene

Variant ID Type Subtype PubMed ID
esv1778065 CNV insertion 17803354
esv2434989 CNV insertion 19546169
esv2731465 CNV deletion 23290073
esv2731466 CNV deletion 23290073
esv274995 CNV loss 21479260
esv3570726 CNV loss 25503493
esv3570727 CNV loss 25503493
esv3570728 CNV loss 25503493
esv3570729 CNV loss 25503493
esv3607900 CNV gain 21293372
esv3607912 CNV gain 21293372
nsv1131934 CNV deletion 24896259
nsv474757 CNV novel sequence insertion 20440878
nsv521426 CNV loss 19592680
nsv830574 CNV gain 17160897

Variation tolerance for MYLK4 Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.17; 87.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYLK4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYLK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYLK4 Gene

Disorders for MYLK4 Gene

Relevant External Links for MYLK4

Genetic Association Database (GAD)
MYLK4
Human Genome Epidemiology (HuGE) Navigator
MYLK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYLK4

No disorders were found for MYLK4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYLK4 Gene

Publications for MYLK4 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 65
  3. The protein kinase complement of the human genome. (PMID: 12471243) Manning G. … Sudarsanam S. (Science 2002) 3 4 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3 65

Products for MYLK4 Gene

Sources for MYLK4 Gene

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