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Aliases for MYLK4 Gene

Aliases for MYLK4 Gene

  • Myosin Light Chain Kinase Family, Member 4 2 3
  • Sugen Kinase 85 3 4
  • CaMLCK Like 2 3
  • EC 4 63
  • SgK085 3 4
  • Myosin Light Chain Kinase Family Member 4 3
  • EC 2.7.11 63

External Ids for MYLK4 Gene

Previous GeneCards Identifiers for MYLK4 Gene

  • GC06M002613

Summaries for MYLK4 Gene

GeneCards Summary for MYLK4 Gene

MYLK4 (Myosin Light Chain Kinase Family, Member 4) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Oxytocin signaling pathway. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is MYLK3.

Tocris Summary for MYLK4 Gene

  • Myosin Light Chain Kinases (MLCKs) are a group of protein serine/threonine kinases that is currently divided into two subtypes, MLCK1 and MLCK2. MLCK1 is found in smooth muscle and phosphorylates myosin II regulatory light chains at Ser19, allowing myosin crossbridges to bind to actin filaments and initiate contraction. In addition to smooth muscle contraction, MLCK1 is involved in a diverse range of biological processes including control of endothelial and vascular permeability, growth initiation of astrocytes processes, neurotransmitter release in the sympathetic nervous system and apoptosis of fibroblasts. MLCK2 is found in striated muscle and co-localizes with phosphorylated MLC filaments to mediate skeletal and cardiac muscle contraction. MLCK3 and MLCK4 have recently been identified but are yet to be fully characterized. MLCKs are activated by Ca2+-calmodulin complexes and require Mg2+ or Ca2+ as a co-factor.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYLK4 Gene

Genomics for MYLK4 Gene

Regulatory Elements for MYLK4 Gene

Genomic Location for MYLK4 Gene

2,663,629 bp from pter
2,765,381 bp from pter
101,753 bases
Minus strand

Genomic View for MYLK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYLK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYLK4 Gene

Proteins for MYLK4 Gene

  • Protein details for MYLK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myosin light chain kinase family member 4
    Protein Accession:
    Secondary Accessions:
    • A2RUC0
    • Q5TAW2

    Protein attributes for MYLK4 Gene

    388 amino acids
    Molecular mass:
    44508 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MYLK4 Gene

    Alternative splice isoforms for MYLK4 Gene


neXtProt entry for MYLK4 Gene

Proteomics data for MYLK4 Gene at MOPED

Selected DME Specific Peptides for MYLK4 Gene

Post-translational modifications for MYLK4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYLK4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MYLK4

Domains for MYLK4 Gene

Suggested Antigen Peptide Sequences for MYLK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q86YV6
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MYLK4: view

Function for MYLK4 Gene

Molecular function for MYLK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for MYLK4 Gene

Gene Ontology (GO) - Molecular Function for MYLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with MYLK4: view
genes like me logo Genes that share phenotypes with MYLK4: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYLK4

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MYLK4 Gene

Localization for MYLK4 Gene

Subcellular locations from

Jensen Localization Image for MYLK4 Gene COMPARTMENTS Subcellular localization image for MYLK4 gene
Compartment Confidence
cytosol 3
nucleus 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MYLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MYLK4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYLK4 Gene

Pathways for MYLK4 Gene

genes like me logo Genes that share pathways with MYLK4: view

Interacting Proteins for MYLK4 Gene

Gene Ontology (GO) - Biological Process for MYLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0009103 lipopolysaccharide biosynthetic process --
genes like me logo Genes that share ontologies with MYLK4: view

Compounds for MYLK4 Gene

(2) Tocris Compounds for MYLK4 Gene

Compound Action Cas Number
ML 7 hydrochloride Selective inhibitor of myosin light chain kinase [110448-33-4]
ML 9 hydrochloride Myosin light chain kinase inhibitor [105637-50-1]

(2) HMDB Compounds for MYLK4 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
genes like me logo Genes that share compounds with MYLK4: view

Transcripts for MYLK4 Gene

mRNA/cDNA for MYLK4 Gene

(17) Selected AceView cDNA sequences:
(6) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYLK4 Gene

Myosin light chain kinase family, member 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYLK4

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYLK4 Gene

No ASD Table

Relevant External Links for MYLK4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYLK4 Gene

mRNA expression in normal human tissues for MYLK4 Gene

mRNA differential expression in normal tissues according to GTEx for MYLK4 Gene

This gene is overexpressed in Muscle - Skeletal (13.5).

Protein differential expression in normal tissues for MYLK4 Gene

This gene is overexpressed in Heart (68.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYLK4 Gene

SOURCE GeneReport for Unigene cluster for MYLK4 Gene Hs.127830

genes like me logo Genes that share expressions with MYLK4: view

Expression partners for MYLK4 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MYLK4 Gene

Orthologs for MYLK4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYLK4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MYLK4 35
  • 84.48 (n)
  • 84.85 (a)
MYLK4 36
  • 91 (a)
(Canis familiaris)
Mammalia MYLK4 35
  • 88.54 (n)
  • 88.89 (a)
MYLK4 36
  • 50 (a)
(Mus musculus)
Mammalia Mylk4 35
  • 84.08 (n)
  • 86.81 (a)
Mylk4 16
Mylk4 36
  • 86 (a)
(Pan troglodytes)
Mammalia MYLK4 35
  • 99.4 (n)
  • 99.23 (a)
MYLK4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mylk4 35
  • 84.89 (n)
  • 88.75 (a)
(Monodelphis domestica)
Mammalia MYLK4 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia MYLK4 36
  • 85 (a)
(Gallus gallus)
Aves MYLK4 35
  • 77.26 (n)
  • 82.78 (a)
MYLK4 36
  • 81 (a)
(Anolis carolinensis)
Reptilia MYLK4 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497991 35
  • 70.78 (n)
  • 76.71 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2372 35
(Danio rerio)
Actinopterygii LOC566845 35
  • 70.92 (n)
  • 71.81 (a)
mylk4a 36
  • 30 (a)
mylk4b 36
  • 32 (a)
fruit fly
(Drosophila melanogaster)
Insecta sqa 36
  • 16 (a)
(Caenorhabditis elegans)
Secernentea ZC373.4 36
  • 12 (a)
Species with no ortholog for MYLK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYLK4 Gene

Gene Tree for MYLK4 (if available)
Gene Tree for MYLK4 (if available)

Paralogs for MYLK4 Gene

Paralogs for MYLK4 Gene

genes like me logo Genes that share paralogs with MYLK4: view

Variants for MYLK4 Gene

Sequence variations from dbSNP and Humsavar for MYLK4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs733985 -- 2,666,698(+) ACACA(C/T)TCATT utr-variant-3-prime
rs745216 -- 2,711,983(-) CCTGC(A/G)TAATG intron-variant
rs745217 -- 2,711,961(-) TTTTC(A/G)TGATT intron-variant
rs898770 -- 2,711,269(+) AATTG(C/T)AGAAA intron-variant
rs898771 -- 2,711,456(+) TTCTT(A/T)GATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYLK4 Gene

Variant ID Type Subtype PubMed ID
nsv883389 CNV Gain 21882294
nsv830574 CNV Gain 17160897
nsv883393 CNV Gain 21882294
nsv521426 CNV Loss 19592680
nsv883394 CNV Loss 21882294
esv2731465 CNV Deletion 23290073
esv2434989 CNV Insertion 19546169
esv2731466 CNV Deletion 23290073
esv1778065 CNV Insertion 17803354
nsv883395 CNV Gain 21882294
esv274995 CNV Loss 21479260

Relevant External Links for MYLK4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYLK4 Gene

Disorders for MYLK4 Gene

Relevant External Links for MYLK4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MYLK4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MYLK4 Gene

Publications for MYLK4 Gene

  1. The protein kinase complement of the human genome. (PMID: 12471243) Manning G. … Sudarsanam S. (Science 2002) 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for MYLK4 Gene

  • Addgene plasmids for MYLK4

Sources for MYLK4 Gene

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