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MYLK4 Gene

protein-coding   GIFtS: 51
GCID: GC06M002663

Myosin Light Chain Kinase Family, Member 4

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin Light Chain Kinase Family, Member 41 2     EC 2.7.11.13 8
CaMLCK Like1 2     Myosin Light Chain Kinase Family Member 42
Sugen Kinase 852 3     SGK0853
SgK0852 3     EC 2.7.118

External Ids:    HGNC: 279721   Entrez Gene: 3401562   Ensembl: ENSG000001459497   UniProtKB: Q86YV63   

Export aliases for MYLK4 gene to outside databases

Previous GC identifer: GC06M002613


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYLK4 Gene:
MYLK4 (myosin light chain kinase family, member 4) is a protein-coding gene. Diseases associated with MYLK4 include endotheliitis. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is STK17B.

summary for MYLK4 Gene:
Myosin Light Chain Kinases (MLCKs) are a group of protein serine/threonine kinases that is currently divided
into two subtypes, MLCK1 and MLCK2. MLCK1 is found in smooth muscle and phosphorylates myosin II regulatory
light chains at Ser19, allowing myosin crossbridges to bind to actin filaments and initiate contraction. In
addition to smooth muscle contraction, MLCK1 is involved in a diverse range of biological processes
including control of endothelial and vascular permeability, growth initiation of astrocytes processes,
neurotransmitter release in the sympathetic nervous system and apoptosis of fibroblasts. MLCK2 is found in
striated muscle and co-localizes with phosphorylated MLC filaments to mediate skeletal and cardiac muscle
contraction. MLCK3 and MLCK4 have recently been identified but are yet to be fully characterized. MLCKs are
activated by Ca2+-calmodulin complexes and require Mg2+ or Ca2+ as a co-factor.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYLK4 gene promoter:
         c-Fos   AP-1   Fra-1   FosB   HNF-4alpha2   HNF-4alpha1   MEF-2A   aMEF-2   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MYLK4 promoter sequence
   Search Chromatin IP Primers for MYLK4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYLK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25.2   Ensembl cytogenetic band:  6p25.2   HGNC cytogenetic band: 6p25.2

MYLK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYLK4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M002663:  view genomic region     (about GC identifiers)

Start:
2,663,863 bp from pter      End:
2,751,200 bp from pter
Size:
87,338 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MYLK4_HUMAN, Q86YV6 (See protein sequence)
Recommended Name: Myosin light chain kinase family member 4  
Size: 388 amino acids; 44508 Da
1 PDB 3D structure from and Proteopedia for MYLK4:
2X4F (3D)    
Secondary accessions: A2RUC0 Q5TAW2
Alternative splicing: 2 isoforms:  Q86YV6-1   Q86YV6-2   (Sequence incomplete. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MYLK4: NX_Q86YV6

Explore proteomics data for MYLK4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MYLK4 (Q86YV6) (see all 7)
     GGELFDR  IIDFGLA  LHLDLKP  DMWSVGVI 


    See MYLK4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001012418.2  
    ENSEMBL proteins: 
     ENSP00000274643   ENSP00000268446  

    MYLK4 Human Recombinant Protein Products:

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    Novus Biologicals MYLK4 Protein
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    Cloud-Clone Corp. Proteins for MYLK4

    MYLK4 Antibody Products:

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    MYLK4 Assay Products:

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    Cloud-Clone Corp. CLIAs for MYLK4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: myosin light chain kinase family, member 4
    Myosin Light Chain Kinase (MLCK) family

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q86YV6

    ProtoNet protein and cluster: Q86YV6

    UniProtKB/Swiss-Prot: MYLK4_HUMAN, Q86YV6
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    MYLK4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYLK4_HUMAN, Q86YV6
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    MYLK4 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MYLK4:
     Decreased Salmonella enterica   Decreased focal adhesion (FA)   Increased colony dispersion (i 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYLK4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYLK4
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    miRNA
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    Block miRNA regulation of human, mouse, rat MYLK4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYLK4 (see all 46):
    hsa-miR-136 hsa-miR-607 hsa-miR-4328 hsa-miR-15a hsa-miR-765 hsa-miR-374a hsa-miR-374c hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidMYLK4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MYLK4
    Predesigned siRNA for gene silencing in human, mouse, rat MYLK4

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: MYLK4 (NM_001012418)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYLK4

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYLK4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----

    MYLK4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYLK4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Oxytocin signaling pathway
    Oxytocin signaling pathway0.32
    Vascular smooth muscle contraction0.32
    2Focal adhesion
    Focal adhesion0.65
    3Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    4Salivary secretion
    Gastric acid secretion0.34
    5Calcium signaling pathway
    Calcium signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    Selected Kegg Pathways  (Kegg details for MYLK4) (see all 6):
        Calcium signaling pathway
    Vascular smooth muscle contraction
    Focal adhesion
    Regulation of actin cytoskeleton
    Oxytocin signaling pathway


    MYLK4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYLK4
    Interactions:

        Search GeneGlobe Interaction Network for MYLK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for MYLK4 (ENSP000002746434) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ULK1ENSP000003245604STRING: ENSP00000324560
    ULK2ENSP000003548774STRING: ENSP00000354877
    RAD1ENSP000003408794STRING: ENSP00000340879
    MYL1ENSP000003072804STRING: ENSP00000307280
    MYL6ENSP000002934224STRING: ENSP00000293422
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0009103lipopolysaccharide biosynthetic process ----

    MYLK4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MYLK4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MLCK inhibitor peptideMyosin light chain kinase inhibitor[198694-74-5]
    ML 9 hydrochlorideMyosin light chain kinase inhibitor[105637-50-1]
    ML 7 hydrochlorideSelective inhibitor of myosin light chain kinase[110448-33-4]

    2 HMDB Compounds for MYLK4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MYLK4 gene: 
    NM_001012418.3  

    Unigene Cluster for MYLK4:

    Myosin light chain kinase family, member 4
    Hs.127830  [show with all ESTs]
    Unigene Representative Sequence: BX647582
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274643(uc003mty.4) ENST00000268446(uc003mtx.4)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MYLK4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYLK4 (see all 46):
    hsa-miR-136 hsa-miR-607 hsa-miR-4328 hsa-miR-15a hsa-miR-765 hsa-miR-374a hsa-miR-374c hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidMYLK4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MYLK4
    Predesigned siRNA for gene silencing in human, mouse, rat MYLK4
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYLK4 (NM_001012418)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYLK4
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MYLK4
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MYLK4
      QuantiTect SYBR Green Assays in human, mouse, rat MYLK4
      QuantiFast Probe-based Assays in human, mouse, rat MYLK4

    Additional mRNA sequence: 

    AK090753.1 AK096893.1 AK122581.1 AK127360.1 BC132831.1 BC132833.1 BX647582.1 

    3 DOTS entries:

    DT.205328  DT.91806915  DT.75172229 

    17 AceView cDNA sequences:

    AA862971 AK122581 BU662434 BU675945 AW005603 AK096893 BQ029866 AK127360 
    BX647582 AK090753 AI683999 BI899555 AW451640 H89078 BF736629 H88988 
    C04755 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYLK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MYLK4 Expression
    About this image

    MYLK4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYLK4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.127830
        Custom PCR Arrays for MYLK4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYLK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MYLK4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mylk41 , 5 myosin light chain kinase family, member 41, 5 84.08(n)1
    86.81(a)1
      13 (13.72 cM)5
    2385641  NM_001166030.11  NP_001159502.11 
     327046805 
    chicken
    (Gallus gallus)
    Aves MYLK41 myosin light chain kinase family, member 4 77.26(n)
    82.78(a)
      420893  XM_418978.4  XP_418978.4 
    lizard
    (Anolis carolinensis)
    Reptilia MYLK46
    myosin light chain kinase family, member 4
    51(a)
    1 ↔ 1
    GL343311.1(805954-985209)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.23722 Xenopus laevis transcribed sequence with weak similarity more 70.78(n)    BG407476.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5668451 myosin light chain kinase 3-like 70.92(n)
    71.81(a)
      566845  XM_690132.6  XP_695224.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta sqa6
    spaghetti-squash activator
    16(a)
    1 → many
    2R(5603981-5635623)
    worm
    (Caenorhabditis elegans)
    Secernentea ZC373.46
    Protein ZC373.4 (ZC373.4) mRNA, complete cds
    12(a)
    1 → many
    X(10062437-10069783) WBGene00013869


    ENSEMBL Gene Tree for MYLK4 (if available)
    TreeFam Gene Tree for MYLK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYLK4 gene
    STK17B2  DAPK22  MYLK22  TTN2  STK17A2  MYLK32  OBSCN2  DAPK32  
    SPEG2  DAPK12  MYLK2  
    Selected SIMAP similar genes for MYLK4 using alignment to 2 protein entries:     MYLK4_HUMAN (see all proteins) (see all similar genes):
    MYLK3    MYLK2    TTN    MYLK    DAPK2    DAPK3
    DAPK1    MARK2    RPS6KA1    STK36    STK17A    RPS6KA2
    BRSK2    STK17B    CAMK4    KALRN    CAMK1    CAMK1D

    MYLK4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYLK4 (see all 2176)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0408664
    A breast infiltrating ductal carcinoma sample4--see VAR_0408662 A S mis40--------
    VAR_0408684
    A lung squamous cell carcinoma sample4--see VAR_0408682 H L mis40--------
    VAR_0408644
    A breast infiltrating ductal carcinoma sample4--see VAR_0408642 E Q mis40--------
    rs673598491,2
    C--2556109(-) TCAAA-/AC/CA 
            
    ACACA
    1 -- int11NA 2
    rs126617431,2
    C,F,H--2663434(+) gggagG/Atgact 1 -- ds50011Minor allele frequency- A:0.04EA 120
    rs733485641,2
    C,F--2663484(+) TGAGTG/CAGTTC 1 -- ds50013Minor allele frequency- C:0.08WA CSA 122
    rs1123814221,2
    C,F--2663509(+) GGTTTC/GAAAGT 1 -- ds50013Minor allele frequency- G:0.07WA CSA 121
    rs1135196271,2
    F--2663519(+) TGTGTC/AATGAG 1 -- ds50012Minor allele frequency- A:0.04CSA WA 119
    rs1811257341,2
    C--2663535(+) TCTCAC/TGAGAT 1 -- ds50010--------
    rs1157340421,2
    C,F--2663536(+) CTCACG/AAGATC 1 -- ds50011Minor allele frequency- A:0.05WA 118

    HapMap Linkage Disequilibrium report for MYLK4 (2663863 - 2751200 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MYLK4 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731466CNV Deletion23290073
    esv2731465CNV Deletion23290073
    esv2434989CNV Insertion19546169
    esv1778065CNV Insertion17803354
    esv274995CNV Loss21479260
    nsv521426CNV Loss19592680
    nsv883394CNV Loss21882294
    nsv883393CNV Gain21882294
    nsv830574CNV Gain17160897
    nsv883395CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYLK4
    DNA2.0 Custom Variant and Variant Library Synthesis for MYLK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for MYLK4:    About MalaCards
    endotheliitis


    MYLK4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MYLK4
    Human Genome Epidemiology (HuGE) Navigator: MYLK4 (1 document)

    Export disorders for MYLK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYLK4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MYLK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    3. The protein kinase complement of the human genome. (PubMed id 12471243)1, 2 Manning G.... Sudarsanam S. (Science 2002)
    4. Genome-wide association study of orthostatic hypotension and supine-standing blood pressure changes in two korean populations. (PubMed id 24124408)1 Hong K.W....Kim Y. (amp 2013)
    5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    6. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    7. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 340156 HGNC: 27972 AceView: LOC340156 Ensembl:ENSG00000145949 euGenes: HUgn340156
    ECgene: MYLK4 Kegg: 340156 H-InvDB: MYLK4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYLK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYLK4 gene:
    Search GeneIP for patents involving MYLK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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