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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYLK3 Gene

protein-coding   GIFtS: 58
GCID: GC16M046736

Myosin Light Chain Kinase 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Myosin Light Chain Kinase 31 2     cardiac-MLCK2
MLCK2 3 5     Cardiac-MyBP-C Associated Ca/CaM Kinase2
MLC Kinase1 2     Putative Myosin Light Chain Kinase 32
Cardiac-MyBP-C-Associated Ca/CaM Kinase2 3     Cardiac-MLCK3
MLCK22     EC 2.7.11.183
caMLCK2     EC 2.7.118

External Ids:    HGNC: 298261   Entrez Gene: 918072   Ensembl: ENSG000001407957   OMIM: 6121475   UniProtKB: Q32MK03   

Export aliases for MYLK3 gene to outside databases

Previous GC identifers: GC16M045293 GC16M032625


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYLK3 Gene:
Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by
a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et
al., 2008 (PubMed 18202317)).(supplied by OMIM, Jul 2008)

GeneCards Summary for MYLK3 Gene: 
MYLK3 (myosin light chain kinase 3) is a protein-coding gene. Diseases associated with MYLK3 include anthrax disease, and diarrhea, and among its related super-pathways are Immune response CCR3 signaling in eosinophils and Cell adhesion Integrin-mediated cell adhesion and migration. GO annotations related to this gene include calmodulin-dependent protein kinase activity and myosin light chain kinase activity. An important paralog of this gene is STK17B.

UniProtKB/Swiss-Prot: MYLK3_HUMAN, Q32MK0
Function: Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases
cardiomyocyte contractility (By similarity)

summary for MYLK3 Gene:
Myosin Light Chain Kinases (MLCKs) are a group of protein serine/threonine kinases that is currently divided
into two subtypes, MLCK1 and MLCK2. MLCK1 is found in smooth muscle and phosphorylates myosin II regulatory
light chains at Ser19, allowing myosin crossbridges to bind to actin filaments and initiate contraction. In
addition to smooth muscle contraction, MLCK1 is involved in a diverse range of biological processes
including control of endothelial and vascular permeability, growth initiation of astrocytes processes,
neurotransmitter release in the sympathetic nervous system and apoptosis of fibroblasts. MLCK2 is found in
striated muscle and co-localizes with phosphorylated MLC filaments to mediate skeletal and cardiac muscle
contraction. MLCK3 and MLCK4 have recently been identified but are yet to be fully characterized. MLCKs are
activated by Ca2+-calmodulin complexes and require Mg2+ or Ca2+ as a co-factor.

Gene Wiki entry for MYLK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYLK3 gene promoter:
         Egr-3   GATA-3   SREBP-1c   RREB-1   GATA-2   GATA-1   Roaz   SREBP-1b   SREBP-1a   GATA-6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYLK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MYLK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYLK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q11.2   Ensembl cytogenetic band:  16q11.2   HGNC cytogenetic band: 16q11.2

MYLK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYLK3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M046736:  view genomic region     (about GC identifiers)

Start:
46,736,194 bp from pter      End:
46,824,319 bp from pter
Size:
88,126 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MYLK3_HUMAN, Q32MK0 (See protein sequence)
Recommended Name: Myosin light chain kinase 3  
Size: 819 amino acids; 88393 Da
Cofactor: Magnesium (By similarity)
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAI09098.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAC42766.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B5BUL9 B7Z5U8 Q32MK1 Q96DV1
Alternative splicing: 2 isoforms:  Q32MK0-3   Q32MK0-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MYLK3: NX_Q32MK0

Explore proteomics data for MYLK3 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on serine residues (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q32MK0

  • 4/6 DME Specific Peptides for MYLK3 (Q32MK0) (see all 6)
     GGELFDR  IIDFGLA  LHLDLKP  DMWSVGVI 

    MYLK3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MYLK3 Protein Expression
    REFSEQ proteins: NP_872299.2  
    ENSEMBL proteins: 
     ENSP00000378288   ENSP00000439297  

    Human Recombinant Protein Products for MYLK3: 
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    Cloud-Clone Corp. Proteins for MYLK3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol ISS--
    GO:0015629actin cytoskeleton IEA--

    MYLK3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: myosin light chain kinase 3 
    Myosin Light Chain Kinase (MLCK) family

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q32MK0

    ProtoNet protein and cluster: Q32MK0

    UniProtKB/Swiss-Prot: MYLK3_HUMAN, Q32MK0
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    MYLK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYLK3_HUMAN, Q32MK0
    Function: Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases
    cardiomyocyte contractility (By similarity)
    Catalytic activity: ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.181

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004683calmodulin-dependent protein kinase activity ISS--
    GO:0004687myosin light chain kinase activity ISS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    MYLK3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MYLK3:
     Decreased focal adhesion (FA)   Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mylk3):
     cardiovascular system  muscle 

    MYLK3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mylk3tm1Jtst for MYLK3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MYLK3 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYLK3 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MYLK3 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response CCR3 signaling in eosinophils
    Immune response CCR3 signaling in eosinophils0.51
    Inhibitory action of Lipoxins on neutrophil migration0.51
    2Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin-mediated cell adhesion and migration0.49
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    3Focal Adhesion
    Focal adhesion0.64
    4Regulation of Actin Cytoskeleton
    Regulation of actin cytoskeleton0.57
    5fMLP Pathway
    Signal transduction Activation of PKC via G-Protein coupled receptor0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for MYLK3
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils
    Signal transduction Activation of PKC via G-Protein coupled receptor


    5/6 GeneGo (Thomson Reuters) Pathways for MYLK3 (see all 6)
        Signal transduction Activation of PKC via G-Protein coupled receptor
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils

    2 BioSystems Pathways for MYLK3
        MicroRNAs in cardiomyocyte hypertrophy
    Cardiac Progenitor Differentiation


    5         Kegg Pathways  (Kegg details for MYLK3):
        Calcium signaling pathway
    Vascular smooth muscle contraction
    Focal adhesion
    Regulation of actin cytoskeleton
    Gastric acid secretion


    MYLK3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MYLK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/26 Interacting proteins for MYLK3 (Q32MK03 ENSP000003782884) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    CALM1ENSP000003494674STRING: ENSP00000349467
    CALML3ENSP000003152994STRING: ENSP00000315299
    CALML5ENSP000003696894STRING: ENSP00000369689
    CALML6ENSP000003046434STRING: ENSP00000304643
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002528regulation of vascular permeability involved in acute inflammatory response IMP18390750
    GO:0006468protein phosphorylation ISS--
    GO:0045214sarcomere organization ISS--
    GO:0048769sarcomerogenesis ISS--
    GO:0055003cardiac myofibril assembly ISS--

    MYLK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MYLK3 for compounds           About GeneDecksing

    EMD Millipore small molecules for MYLK3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MYLK3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MLCK inhibitor peptideMyosin light chain kinase inhibitor[198694-74-5]
    ML 9 hydrochlorideMyosin light chain kinase inhibitor[105637-50-1]
    ML 7 hydrochlorideSelective inhibitor of myosin light chain kinase[110448-33-4]

    4 HMDB Compounds for MYLK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--

    8 Novoseek inferred chemical compound relationships for MYLK3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kt 5926 83.4 2 1371921 (1), 10930508 (1)
    actomyosin 65.1 2 7767891 (1), 15825080 (1)
    wortmannin 42.5 9 1371921 (2), 7996204 (2), 16284075 (1)
    pd 98,059 34.3 2 12532105 (1), 16034127 (1)
    cytochalasin b 33.5 2 11052983 (2)
    calcium 11.3 5 14687859 (2), 7767891 (1), 17241155 (1)
    phosphatidylinositol 4.17 1 10930508 (1)
    ethanol 0 10 17241155 (3), 10198341 (3)

    Search CenterWatch for drugs/clinical trials and news about MYLK3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYLK3 gene: 
    NM_182493.2  

    Unigene Cluster for MYLK3:

    Myosin light chain kinase 3
    Hs.130465  [show with all ESTs]
    Unigene Representative Sequence: NM_182493
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394809(uc002eei.4 uc010vge.2) ENST00000536476 ENST00000565182
    ENST00000562104 ENST00000564731(uc002eej.1) ENST00000569844 ENST00000569810

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    Additional mRNA sequence: 

    AB451455.1 AJ247087.1 AK299443.1 BC039103.1 BC109096.1 BC109097.1 

    6 DOTS entries:

    DT.40313888  DT.101961731  DT.99982217  DT.120721626  DT.100656008  DT.40237473 

    6 AceView cDNA sequences:

    Z36720 NM_182493 AJ247087 BC039103 BG719152 BF059578 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYLK3 expression in normal human tissues (normalized intensities)      MYLK3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCCAGGA
    MYLK3 Expression
    About this image


    MYLK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Heart (Cardiovascular System)

    See MYLK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYLK3

    SOURCE GeneReport for Unigene cluster: Hs.130465

    UniProtKB/Swiss-Prot: MYLK3_HUMAN, Q32MK0
    Tissue specificity: Restricted to heart

        SABiosciences Expression via Pathway-Focused PCR Array including MYLK3: 
              Hypertension in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYLK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MYLK3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mylk31 , 5 myosin light chain kinase 31, 5 77.36(n)1
    71.48(a)1
      8 (41.61 cM)5
    2134351  NM_175441.51  NP_780650.21 
     853243035 
    chicken
    (Gallus gallus)
    Aves MYLK31 myosin light chain kinase 3 56.95(n)
    53.16(a)
      415748  XM_414113.3  XP_414113.3 
    lizard
    (Anolis carolinensis)
    Reptilia MYLK36
    myosin light chain kinase 3
    65(a)
    1 ↔ 1
    LGc(3560250-3586928)
    zebrafish
    (Danio rerio)
    Actinopterygii mylk36
    myosin light chain kinase 3
    39(a)
    1 ↔ 1
    7(44551781-44587973)
    fruit fly
    (Drosophila melanogaster)
    Insecta sqa6
    spaghetti-squash activator
    17(a)
    1 → many
    2R(5603981-5635623)
    worm
    (Caenorhabditis elegans)
    Secernentea ZC373.46
    Protein ZC373.4
    12(a)
    possible ortholog
    X(10062437-10069783)


    ENSEMBL Gene Tree for MYLK3 (if available)
    TreeFam Gene Tree for MYLK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYLK3 gene
    STK17B2  DAPK22  MYLK22  TTN2  STK17A2  DAPK32  SPEG2  MYLK42  
    DAPK12  MYLK2  
    18/29 SIMAP similar genes for MYLK3 using alignment to 2 protein entries:     MYLK3_HUMAN (see all proteins) (see all similar genes):
    MYLK4    DAPK3    STK17A    DAPK2    PRKY    STK17B
    CAMK2B    CAMK1D    CAMK4    MYLK2    NUAK1    PRKAA1
    STK11    DKFZp564L2416    RPS6KA2    CAMK1    CAMK2D    KIN27

    MYLK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/856 SNPs in MYLK3 are shown (see all 856)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356304
    A colorectal cancer sample4--see VAR_0356302 G R mis40--------
    rs1453903501,2
    --46735900(+) AACGTC/TGGACT 1 -- ds50010--------
    rs1426539041,2
    C--46736075(+) ATTACA/GTATAT 1 -- ds50010--------
    rs1906184251,2
    --46736149(+) GAATTC/TGTGTG 1 -- ds50010--------
    rs1152471371,2
    C,F--46736150(+) AATTCG/ATGTGT 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1467137341,2
    --46736204(+) TAACCA/GTTCTT 1 -- ut310--------
    rs3701591,2
    C,F,A,H--46736263(-) TGTATA/GTATTT 1 -- ut31102Minor allele frequency- G:0.09NS EA PA EU CA WA NA CSA 6187
    rs1479388231,2
    C--46736275(+) CAGTAA/GAGAGG 1 -- ut310--------
    rs1416366251,2
    --46736559(+) CCAGGC/TGCAGT 1 -- ut310--------
    rs1828672961,2
    --46736804(+) CTCCAG/TCCTGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MYLK3 (46736194 - 46824319 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MYLK3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv526656CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612147    OMIM disorders: --

    9 diseases for MYLK3:    About MalaCards
    anthrax disease    diarrhea    endotheliitis    fibrosarcoma
    inflammatory bowel disease    crohn's disease    hypoxia    alcoholism
    hypertension


    MYLK3 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for MYLK3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bowel disease 60.4 1 15906163 (1)
    necrosis 17.9 2 20177070 (1), 19027740 (1)
    tumors 0 7 19826488 (3), 20177070 (1), 19027740 (1)


    Export disorders for MYLK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYLK3 gene, integrated from 9 sources (see all 86):
    (articles sorted by number of sources associating them with MYLK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart. (PubMed id 17885681)1, 2, 3 Seguchi O....Kitakaze M. (2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability. (PubMed id 18390750)1, 9 Al-Sadi R....Ma T.Y. (2008)
    4. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    5. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)1 Toyoshima M....Grandori C. (2012)
    6. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    7. Identification of cardiac-specific myosin light chain kinase. (PubMed id 18202317)1 Chan J.Y....Kasahara H. (2008)
    8. Human protein factory for converting the transcriptome into an in vitro-expressed proteome. (PubMed id 19054851)2 Goshima N.... Nomura N. (2008)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91807 HGNC: 29826 AceView: LOC91807 Ensembl:ENSG00000140795 euGenes: HUgn91807
    ECgene: MYLK3 Kegg: 91807 H-InvDB: MYLK3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYLK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYLK3 gene:
    Search GeneIP for patents involving MYLK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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