MYLK2 Gene
protein-coding GIFtS: 63
GCID: GC20P030407
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|
myosin light chain kinase 2(Previous names: myosin light chain kinase 2, skeletal muscle )
| |
Aliases
for MYLK2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Myosin Light Chain Kinase 21 2 | | EC 2.7.11.183 8 | | MLCK21 2 3 | | MLCK2 5 | | KMLC1 2 | | Myosin Light Chain Kinase 2, Skeletal/Cardiac Muscle2 | | Myosin Light Chain Kinase 2, Skeletal Muscle1 2 | | EC 2.7.118 | | SkMLCK1 | | |
Export aliases for MYLK2 gene to outside databasesPrevious GC identifers: GC20P030195 GC20P031105 GC20P031152 GC20P029870 GC20P027196 |
Summaries
for MYLK2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MYLK2:
This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed inadult skeletal muscle. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MYLK2_HUMAN, Q9H1R3Function: Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serinein the N-terminus of a myosin light chain
 summary
for MYLK2: Myosin Light Chain Kinases (MLCKs) are a group of protein serine/threonine kinases that is currently divided
into two subtypes, MLCK1 and MLCK2. MLCK1 is found in smooth muscle and phosphorylates myosin II regulatory
light chains at Ser19, allowing myosin crossbridges to bind to actin filaments and initiate contraction. In
addition to smooth muscle contraction, MLCK1 is involved in a diverse range of biological processes
including control of endothelial and vascular permeability, growth initiation of astrocytes processes,
neurotransmitter release in the sympathetic nervous system and apoptosis of fibroblasts. MLCK2 is found in
striated muscle and co-localizes with phosphorylated MLC filaments to mediate skeletal and cardiac muscle
contraction. MLCK3 and MLCK4 have recently been identified but are yet to be fully characterized. MLCKs are
activated by Ca2+-calmodulin complexes and require Mg2+ or Ca2+ as a co-factor.
Gene Wiki entry for MYLK2
|
Genomic Views
for MYLK2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MYLK2 gene promoter:
SRF SRF (504 AA) YY1 C/EBPalpha E47 CHOP-10 AREB6 Hand1 ZID Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for MYLK2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYLK2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.31 Ensembl cytogenetic band: 20q11.21 HGNC cytogenetic band: 20q13.31MYLK2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P030407: view genomic region
(about GC identifiers)
Start:
|
30,407,111 bp from pter |
End:
|
30,422,500 bp from pter |
Size:
|
15,390 bases |
Orientation:
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plus strand |
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Proteins
for MYLK2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MYLK2_HUMAN, Q9H1R3 (See
protein sequence)Recommended Name: Myosin light chain kinase 2, skeletal/cardiac muscle Size: 596 amino acids; 64685 Da
Subunit: May interact with centrin
Subcellular location: Cytoplasm. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of themyofibrils
1 PDB 3D structure from  and Proteopedia  for MYLK2:3KF9 (3D)
Secondary accessions: Q569L1 Q96I84Explore the universe of human proteins at neXtProt for MYLK2: NX_Q9H1R3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H1R3
4/9 DME Specific Peptides for MYLK2 (Q9H1R3) (see all 9)
MYLK2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_149109.1
ENSEMBL proteins: ENSP00000365162 ENSP00000365152
Human Recombinant Protein Products:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
MYLK2 for ontologies About GeneDecksing
MYLK2 Antibody Products:
Assay Products for MYLK2: |
Protein
Domains /
Families
for MYLK2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MYLK2 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9H1R3ProtoNet protein and cluster: Q9H1R3 UniProtKB/Swiss-Prot: MYLK2_HUMAN, Q9H1R3Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase familySimilarity: Contains 1 protein kinase domain |
Function
for MYLK2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MYLK2_HUMAN, Q9H1R3Function: Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serinein the N-terminus of a myosin light chainCatalytic activity: ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphateEnzyme Numbers (IUBMB): EC 2.7.11.181 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYLK2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYLK2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MYLK2 (NM_033118) | |  | Sino Biological Human cDNA Clone for MYLK2 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYLK2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYLK2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYLK2 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
MYLK2 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for MYLK2:
Animal Models:
Mouse knock-out Mylk2tm1Jtst for MYLK2
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Mylk2):
MYLK2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MYLK2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell adhesion_Integrin-mediated cell adhesion and migration | | | 2 | Immune response _CCR3 signaling in eosinophils | | | 3 | Focal Adhesion | | | 4 | Signal transduction_Activation of PKC via G-Protein coupled receptor | | | 5 | Regulation of Water Balance by Renal Aquaporins | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 EMD Millipore Pathways for MYLK2
5/6  GeneGo (Thomson Reuters) Pathways for MYLK2 (see all 6)
3  BioSystems Pathways for MYLK2
5 
Kegg Pathways (Kegg details for MYLK2):
MYLK2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MYLK2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/118 Interacting proteins for MYLK2 (Q9H1R32, 3 ENSP000003651524) via UniProtKB, MINT, STRING, and/or I2D (see all 118)About this table
Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21): About this table
MYLK2 for ontologies About GeneDecksing
|
Drugs & Compounds
for MYLK2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MYLK2 for compounds About GeneDecksing
Compounds for MYLK2 available from Tocris Bioscience About this table
3 HMDB Compounds for MYLK2 About this table
10/16 Novoseek chemical compound relationships for MYLK2 gene (see all 16) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| actomyosin |
56.3 |
3 |
9047304 (1), 2369131 (1), 1710106 (1) |
| norleucine |
54.5 |
1 |
10210190 (1) |
| ethionine |
54.1 |
1 |
10210190 (1) |
| selenomethionine |
47.2 |
1 |
9485473 (1) |
| calcium |
45.7 |
46 |
8144585 (6), 8063799 (4), 9922147 (4), 9848178 (3) (see all 19) |
| amp-pnp |
35.6 |
1 |
9760234 (1) |
| atp |
32.6 |
11 |
8250857 (3), 8060530 (2), 7575484 (1), 7767880 (1) (see all 6) |
| threonine |
25.8 |
2 |
12297722 (1), 16448786 (1) |
| adp |
25.3 |
1 |
15598663 (1) |
| wortmannin |
22.7 |
10 |
7492304 (4), 11294240 (1), 9716716 (1) |
Search CenterWatch for drugs/clinical trials and news about MYLK2
|
Transcripts
for MYLK2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MYLK2 gene: NM_033118.3 Unigene Cluster for MYLK2: Myosin light chain kinase 2 Hs.86092 [show with all ESTs]Unigene Representative Sequence: BX6476353 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000375994 ENST00000375985(uc002wwq.2) ENST00000468730(uc002wws.2 uc010gdw.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYLK2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYLK2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MYLK2 (NM_033118) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYLK2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYLK2 |
Additional cDNA sequence: AF325549.1 AJ272502.1 BC007753.1 BC069627.1 BC092413.1 BC127622.1 BX647635.1 3 DOTS entries: DT.95365694 DT.102824532 DT.101982260 24/34 AceView cDNA sequences (see all 34): CF552239 BC007753 AF325549 BC069627 NM_033118 AJ572379 BX647635 F31270 BG825412 F22840 AJ272502 CF455472 CD634744 CD634733 AW444680 CD634737 CD634749 AJ346142 CD634747 F37398 CD634739 AA196011 CD634750 BF204753
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for MYLK2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MYLK2
|
Expression
for MYLK2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MYLK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGCAGCCTC
About this image
See MYLK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MYLK2
SOURCE GeneReport for Unigene cluster: Hs.86092
UniProtKB/Swiss-Prot: MYLK2_HUMAN, Q9H1R3Tissue specificity: Heart and skeletal muscles. Increased expression in the apical tissue compared to theinterventricular septal tissue
SABiosciences Expression via Pathway-Focused PCR Arrays including MYLK2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYLK2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MYLK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYLK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYLK2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYLK2 |
Orthologs
for MYLK2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MYLK2 gene from 5/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MYLK21 |
myosin light chain kinase 2 |
65.6(n)
61.61(a) |
|
396356 NM_205392.1 NP_990723.1 |
lizard
(Anolis carolinensis) |
Reptilia |
MYLK26 |
-- |
81(a) |
1 ↔ 1 |
GL343768.1(721-11828) |
zebrafish
(Danio rerio) |
Actinopterygii |
mylk26 |
myosin light chain kinase 2 |
31(a) |
1 ↔ 1 |
23(32277965-32299462) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG17763
CG423471 |
protein amino acid phosphorylation protein
serine/threonine more3
CG423471 |
48(a)3
56.74(n)1
49.65(a)1 |
|
46B23
360021 NM_136670.21 NP_610514.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
ZC373.43 |
calcium/calmodulin dependent protein kinase |
41(a) |
|
X(10098022-10105019) -- |
ENSEMBL Gene Tree for MYLK2 (if available)
TreeFam Gene Tree for MYLK2 (if available) |
Paralogs
for MYLK2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MYLK2 gene
- STK17B2 DAPK22 TTN2 MYLK32 STK17A2 OBSCN2 DAPK32 SPEG2
- MYLK42 DAPK12 MYLK2 OBSL12
8 SIMAP similar genes for MYLK2 using alignment to 1 protein entry: MYLK2_HUMAN:MYLK4 STK17A PRKAA1 MYLK3 PSKH2 CAMK1
PSKH1 MYLK
MYLK2 for paralogs About GeneDecksing
|
Genomic Variants
for MYLK2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MYLK2 (30407111 - 30422500 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MYLK2: --
Human Gene Mutation Database (HGMD): MYLK2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYLK2 |
|
Disorders
/ Diseases
for MYLK2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MYLK2 for disorders About GeneDecksing
OMIM gene information: 606566
OMIM disorders: 192600
UniProtKB/Swiss-Prot: MYLK2_HUMAN, Q9H1R3
Defects in MYLK2 are a cause of familial hypertrophic cardiomyopathy (CMH) [MIM:192600]; also designated FHCor HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy,which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope,collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- andintrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiacdeath
8  diseases for MYLK2: About MalaCardsmegakaryoblastic leukemia breast cancer pancreatic cancer ischemia
pancreatitis leukemia esophagitis neuronitis
1 Novoseek disease relationship for MYLK2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| breast cancer |
0 |
6 |
20453870 (2), 18710790 (2) |
Human Genome Epidemiology (HuGE) Navigator: MYLK2 (9 documents)
Export disorders for MYLK2 gene to outside databases
|
Publications
for MYLK2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MYLK2 gene, integrated from 9 sources (see all 148):
(articles sorted by number of sources associating them with MYLK2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The overall pattern of cardiac contraction depends on a spatial gradient of myosin regulatory light chain phosphorylation. (PubMed id 11733062)1, 2 Davis J.S.... Epstein N.D. (2001)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Single-molecule force spectroscopy distinguishes targ et binding modes of calmodulin. (PubMed id 19667195)1, 9 Junker J.P. and Rief M. (2009)
- Mutational analysis of the kinase domain of MYLK2 gene in common human cancers. (PubMed id 16448786)1, 9 Soung Y.H....Lee S.H. (2006)
- Acetylation regulates gluconeogenesis by promoting PE PCK1 degradation via recruiting the UBR5 ubiquitin ligase. (PubMed id 21726808)1 Jiang W....Zhao S. (2011)
- Identification of proteins associated with ligand-acti vated estrogen receptor a in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PubMed id 21182205)1 Tarallo R....Weisz A. (2011)
- Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. (PubMed id 20618440)1 Pozuelo-Rubio M. (2010)
- System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
- Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma. (PubMed id 18828194)1 Christie J.D....Garcia J.G. (2008)
|
External Searches for MYLK2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MYLK2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MYLK2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MYLK2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MYLK2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MYLK2 gene:
Search GeneIP for patents involving MYLK2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MYLK2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MYLK2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYLK2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYLK2 | | | OriGene Protein Over-expression Lysate for MYLK2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MYLK2 | | OriGene 3'-UTR Clone for MYLK2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYLK2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYLK2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MYLK2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MYLK2 | | OriGene Custom Protein Services for MYLK2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MYLK2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYLK2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYLK2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYLK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYLK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYLK2 |
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 | | | MYLK2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYLK2 |
|  |  |  | | | | ThermoFisher Antibodies for MYLK2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYLK2 |
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