Aliases for MYLK2 Gene
External Ids for MYLK2 Gene
Previous GeneCards Identifiers for MYLK2 Gene
This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle. [provided by RefSeq, Jul 2008]
GeneCards Summary for MYLK2 Gene
MYLK2 (Myosin Light Chain Kinase 2) is a Protein Coding gene. Diseases associated with MYLK2 include cardiomyopathy, familial hypertrophic, 1 and caveolinopathies. Among its related pathways are Regulation of actin cytoskeleton and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include calmodulin binding and myosin light chain kinase activity. An important paralog of this gene is MYLK4.
UniProtKB/Swiss-Prot for MYLK2 Gene
Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.
Myosin Light Chain Kinases (MLCKs) are a group of protein serine/threonine kinases that is currently divided into two subtypes, MLCK1 and MLCK2. MLCK1 is found in smooth muscle and phosphorylates myosin II regulatory light chains at Ser19, allowing myosin crossbridges to bind to actin filaments and initiate contraction. In addition to smooth muscle contraction, MLCK1 is involved in a diverse range of biological processes including control of endothelial and vascular permeability, growth initiation of astrocytes processes, neurotransmitter release in the sympathetic nervous system and apoptosis of fibroblasts. MLCK2 is found in striated muscle and co-localizes with phosphorylated MLC filaments to mediate skeletal and cardiac muscle contraction. MLCK3 and MLCK4 have recently been identified but are yet to be fully characterized. MLCKs are activated by Ca2+-calmodulin complexes and require Mg2+ or Ca2+ as a co-factor.