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MYLK Gene

protein-coding   GIFtS: 72
GCID: GC03M123281

Myosin Light Chain Kinase

(Previous names: myosin, light polypeptide kinase)
  See MYLK-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin Light Chain Kinase1 2     EC 2.7.11.183 8
MLCK2 3 5     AAT72 5
Myosin, Light Polypeptide Kinase1 2     MLCK1082
Smooth Muscle Myosin Light Chain Kinase1 2     MLCK2102
Kinase-Related Protein2 3     MSTP0832
KRP2 3     Myosin Light Chain Kinase, Smooth Muscle2
MLCK12 3     telokin2
MYLK12 3     Telokin3
smMLCK2 3     EC 2.7.118

External Ids:    HGNC: 75901   Entrez Gene: 46382   Ensembl: ENSG000000655347   OMIM: 6009225   UniProtKB: Q157463   

Export aliases for MYLK gene to outside databases

Previous GC identifers: GC03M120053 GC03M124614 GC03M124653 GC03M124813 GC03M120704


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYLK Gene:
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a
calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate
myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and
nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a
small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently
expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located
on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin
dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional
variants have been identified but lack full length transcripts. (provided by RefSeq, Jul 2008)

GeneCards Summary for MYLK Gene:
MYLK (myosin light chain kinase) is a protein-coding gene. Diseases associated with MYLK include aortic aneurysm, familial thoracic 7, and mylk-related thoracic aortic aneurysms and aortic dissections. GO annotations related to this gene include actin binding and myosin light chain kinase activity. An important paralog of this gene is STK17B.

UniProtKB/Swiss-Prot: MYLK_HUMAN, Q15746
Function: Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via
phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase
activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g.
apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and
other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for
physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the
regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal
rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes
in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion
cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the
regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring
contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel
activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane.
Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation
mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury
(ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation.
Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates
burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular
hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia
spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of
cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent
activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for
high proliferative ability of breast cancer cells through anti-apoptosis

summary for MYLK Gene:
Myosin Light Chain Kinases (MLCKs) are a group of protein serine/threonine kinases that is currently divided
into two subtypes, MLCK1 and MLCK2. MLCK1 is found in smooth muscle and phosphorylates myosin II regulatory
light chains at Ser19, allowing myosin crossbridges to bind to actin filaments and initiate contraction. In
addition to smooth muscle contraction, MLCK1 is involved in a diverse range of biological processes
including control of endothelial and vascular permeability, growth initiation of astrocytes processes,
neurotransmitter release in the sympathetic nervous system and apoptosis of fibroblasts. MLCK2 is found in
striated muscle and co-localizes with phosphorylated MLC filaments to mediate skeletal and cardiac muscle
contraction. MLCK3 and MLCK4 have recently been identified but are yet to be fully characterized. MLCKs are
activated by Ca2+-calmodulin complexes and require Mg2+ or Ca2+ as a co-factor.

Gene Wiki entry for MYLK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYLK gene promoter:
         AML1a   p53   STAT5A   CUTL1   GATA-2   FOXJ2 (long isoform)   FOXO1a   FOXJ2   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MYLK promoter sequence
   Search Chromatin IP Primers for MYLK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYLK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21   Ensembl cytogenetic band:  3q21.1   HGNC cytogenetic band: 3q21

MYLK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYLK gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M123281:  view genomic region     (about GC identifiers)

Start:
123,328,896 bp from pter      End:
123,603,178 bp from pter
Size:
274,283 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MYLK_HUMAN, Q15746 (See protein sequence)
Recommended Name: Myosin light chain kinase, smooth muscle  
Size: 1914 amino acids; 210715 Da
Cofactor: Magnesium
Cofactor: Calcium
Subunit: All isoforms including Telokin bind calmodulin. Interacts with SVIL (By similarity). Interacts with CTTN;
this interaction is reduced during thrombin-induced endothelial cell (EC) contraction but is promoted by the
barrier-protective agonist sphingosine 1-phosphate (S1P) within lamellipodia. A complex made of ABL1, CTTN and
MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated
endothelial cell (EC) barrier enhancement. Binds to NAA10/ARD1 and PTK2B/PYK2
Miscellaneous: In asthmatic patients, overexpression promotes actin filament propulsion, thus contributing to
airway hyperresponsiveness. Some MYLK variants may contribute to acute lung injury (ALI) susceptibility.
Potential therapeutic target in the treatment of burn edema
Sequence caution: Sequence=AAD15922.1; Type=Frameshift; Positions=1433; Sequence=AAD15923.1; Type=Frameshift;
Positions=1433; Sequence=AAD15924.1; Type=Frameshift; Positions=1433;
3 PDB 3D structures from and Proteopedia for MYLK:
2CQV (3D)        2K0F (3D)        2YR3 (3D)    
Secondary accessions: B4DUE3 D3DN97 O95796 O95797 O95798 O95799 Q14844 Q16794 Q17S15 Q3ZCP9
Q5MY99 Q5MYA0 Q6P2N0 Q7Z4J0 Q9C0L5 Q9UBG5 Q9UBY6 Q9UIT9
Alternative splicing, Alternative initiation: 11 isoforms:  Q15746-1   Q15746-2   Q15746-3   Q15746-4   Q15746-5   Q15746-6   Q15746-7   Q15746-8   
Q15746-9   Q15746-10   Q15746-11   (Produced by alternative initiation at Met-923 of isoform 1)

Explore the universe of human proteins at neXtProt for MYLK: NX_Q15746

Explore proteomics data for MYLK at MOPED

Post-translational modifications: 

  • Can probably be down-regulated by phosphorylation. Tyrosine phosphorylation by ABL1 increases kinase activity,
    reverses MLCK-mediated inhibition of Arp2/3-mediated actin polymerization, and enhances CTTN-binding.
    Phosphorylation by SRC at Tyr-464 and Tyr-471 promotes CTTN binding1
  • The C-terminus is deglutamylated by AGTPBP1/CCP1, AGBL1/CCP4 and AGBL4/CCP6, leading to the formation of Myosin
    light chain kinase, smooth muscle, deglutamylated form. The consequences of C-terminal deglutamylation are
    unknown (By similarity)1
  • Acetylated at Lys-608 by NAA10/ARD1 via a calcium-dependent signaling; this acetylation represses kinase activity
    and reduces tumor cell migration1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MYLK (Q15746) (see all 18)
     SCQVTVD  SEEDVSQ  GKYTCEA  YTCKAVN 


    See MYLK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_444253.3  NP_444254.3  NP_444255.3  NP_444256.3  NP_444259.1  NP_444260.1  

    ENSEMBL proteins: 
     ENSP00000354004   ENSP00000428967   ENSP00000463691   ENSP00000417798   ENSP00000320622  
     ENSP00000462118   ENSP00000418335   ENSP00000422984   ENSP00000353452   ENSP00000352088  
     ENSP00000346846  
    Reactome Protein details: Q15746

    MYLK Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MYLK Protein
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    OriGene Protein Over-expression Lysate for MYLK
    OriGene MassSpec for MYLK
    OriGene Custom Protein Services for MYLK
    GenScript Custom Purified and Recombinant Proteins Services for MYLK
    Novus Biologicals MYLK Proteins
    Novus Biologicals MYLK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYLK

     
    Search eBioscience for Proteins for MYLK 

     
    antibodies-online proteins for MYLK (11 products) 

     
    Search antibodies-online for peptides for MYLK

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    antibodies-online antibodies for MYLK (36 products) 

    MYLK Assay Products:

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    GenScript Custom Assay Services for MYLK
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    Cloud-Clone Corp. ELISAs for MYLK
    Cloud-Clone Corp. CLIAs for MYLK
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    antibodies-online kits for MYLK (22 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: myosin light chain kinase
    Selected non-AGC protein kinase activities
    Myosin Light Chain Kinase (MLCK) family

    Selected InterPro protein domains (see all 13):
     IPR003598 Ig_sub2
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set

    Graphical View of Domain Structure for InterPro Entry Q15746

    ProtoNet protein and cluster: Q15746

    1 Blocks protein domain: IPB003962 Fibronectin type III repeat signature

    UniProtKB/Swiss-Prot: MYLK_HUMAN, Q15746
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 9 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with MYLK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYLK_HUMAN, Q15746
    Function: Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via
    phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase
    activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g.
    apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and
    other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for
    physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the
    regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal
    rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes
    in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion
    cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the
    regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring
    contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel
    activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane.
    Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation
    mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury
    (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation.
    Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates
    burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular
    hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia
    spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of
    cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent
    activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for
    high proliferative ability of breast cancer cells through anti-apoptosis
    Catalytic activity: ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate
    Enzyme regulation: Isoform 1 is activated by phosphorylation on Tyr-464 and Tyr-471. Isoforms which lack these
    tyrosine residues are not regulated in this way. All catalytically active isoforms require binding to calcium and
    calmodulin for activation. Repressed by organometallic pyridylnaphthalimide complexes, wortmannin, ML-7 (a
    synthetic naphthalenesulphonyl derivative that inhibits the binding of ATP to MLCK) and ML-9
    Biophysicochemical properties: Kinetic parameters: KM=6.5 uM for MLC (isoform 1 at 22 degrees Celsius); KM=7.2 uM
    for MLC (isoform 2 at 22 degrees Celsius); Vmax=11.9 umol/min/mg enzyme (isoform 1 at 22 degrees Celsius);
    Vmax=10.9 umol/min/mg enzyme (isoform 1 at 22 degrees Celsius);
    Induction: Accumulates in individuals with asthma (at protein levels). Induced by tumor necrosis factor (TNF).
    Repressed by androgens (e.g. R1881)

         Genatlas biochemistry entry for MYLK:
    myosin,light chain kinase,Ca2+/calmodulin dependent,expressed in smooth muscle and four non muscle
    isoforms,including a short isoform named telokin (KRP-kinase related protein),expressed noteworthy in neurons and
    glia,in liver,lung and kidney and endothelial cells (hippocampus,entorhinal and frontal cortex),stimulating
    myosin ATPase activity without phosphorylating myosin light chain

         Enzyme Numbers (IUBMB): EC 2.7.11.181 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004683calmodulin-dependent protein kinase activity IBA--
    GO:0004687myosin light chain kinase activity IDA16284075
         
    Find genes that share ontologies with MYLK           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for MYLK:
     Decreased substrate adherent c  Increased cell death in breast  Stronger migration  Upregulation of Wnt/beta-caten 
     Wnt reporter downregulated 

         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mylk):
     behavior/neurological  cardiovascular system  digestive/alimentary  growth/size/body  homeostasis/metabolism 
     immune system  mortality/aging  muscle  normal  renal/urinary system 
     skeleton 

    Find genes that share phenotypes with MYLK           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MYLK: Mylktm1Avs Mylktm1Dmw

       genOway: Develop your customized and physiologically relevant rodent model for MYLK

    miRNA
    Products:
        
    miRTarBase miRNAs that target MYLK:
    hsa-mir-193b-3p (MIRT016318), hsa-mir-9-5p (MIRT021378)

    Block miRNA regulation of human, mouse, rat MYLK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYLK (see all 57):
    hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-15a hsa-miR-503 hsa-miR-374a hsa-miR-519a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidMYLK 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat MYLK

    Gene Editing
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    Products:
         
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    GenScript: all cDNA clones in your preferred vector (see all 6): MYLK (NM_053026)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYLK
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    Addgene plasmids for MYLK 

    Cell Line
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    ESI BIO PureStem Progenitor for MYLK: 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYLK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYLK_HUMAN, Q15746: Cytoplasm. Cell projection, lamellipodium. Cleavage furrow. Cytoplasm, cytoskeleton.
    Note=Localized to stress fibers during interphase and to the cleavage furrow during mitosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    plasma membrane4
    endoplasmic reticulum2
    extracellular2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IDA15020676
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane ----
    GO:0030027lamellipodium IDA--

    Find genes that share ontologies with MYLK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYLK About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    4fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    5Integrin Pathway
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38


    Find genes that share SuperPaths with MYLK           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYLK (see all 14)
        RhoA Pathway
    PKA Signaling
    Actin-Based Motility by Rho Family GTPases
    CDC42 Pathway
    Signaling Involved in Cardiac Hypertrophy

    Selected GeneGo (Thomson Reuters) Pathways for MYLK (see all 6)
        Signal transduction Activation of PKC via G-Protein coupled receptor
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils

    5 BioSystems Pathways for MYLK
        MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    Regulation of Actin Cytoskeleton
    Endothelin
    Aurora B signaling

    1 Reactome Pathway for MYLK
        Smooth Muscle Contraction


    Selected Kegg Pathways  (Kegg details for MYLK) (see all 6):
        Calcium signaling pathway
    Vascular smooth muscle contraction
    Focal adhesion
    Regulation of actin cytoskeleton
    Oxytocin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MYLK: 
              Hypertension in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MYLK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYLK (Q157461, 2, 3 ENSP000003534524) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-8112111 I2D: score=3 STRING: ENSP00000274335
    MYL12AP191052, 3, ENSP000002176524MINT-8150278 I2D: score=1 STRING: ENSP00000217652
    CALM1P621583, ENSP000003494674I2D: score=3 STRING: ENSP00000349467
    CALM2P621583I2D: score=3 
    CALM3P621583I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS8575746
    GO:0006936muscle contraction TAS--
    GO:0006939smooth muscle contraction ISS--
    GO:0007015actin filament organization IBA--
    GO:0014820tonic smooth muscle contraction ISS--

    Find genes that share ontologies with MYLK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MYLK
      Browse compounds at ApexBio 

    Compounds for MYLK available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MLCK inhibitor peptideMyosin light chain kinase inhibitor[198694-74-5]
    ML 9 hydrochlorideMyosin light chain kinase inhibitor[105637-50-1]
    ML 7 hydrochlorideSelective inhibitor of myosin light chain kinase[110448-33-4]

    4 HMDB Compounds for MYLK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 IUPHAR Ligand for MYLK (myosin light chain kinase)    About this table
    LigandTypeActionAffinityPubmed IDs
    calmodulin
    ActivatorNone156362

    Selected Novoseek inferred chemical compound relationships for MYLK gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    blebbistatin 84 3 17925381 (1), 17412815 (1), 16672772 (1)
    kt 5926 80.1 9 10640419 (1), 8388002 (1), 1313815 (1), 9240372 (1) (see all 5)
    actomyosin 74.3 9 11606635 (2), 7611441 (1), 8409758 (1), 11062269 (1) (see all 6)
    calyculin a 65.7 3 9806741 (1)
    wortmannin 44.3 7 17093082 (2), 8555484 (1), 19160680 (1), 11304465 (1) (see all 5)
    fasudil 40.2 1 16299551 (1)
    threonine 40.1 3 10493949 (1), 11529681 (1), 10047984 (1)
    calcium 39.7 53 11976941 (5), 9506478 (4), 11346659 (4), 16051224 (3) (see all 24)
    2,3-butanedione monoxime 37.3 2 16672772 (1), 11807939 (1)
    serine 32.8 5 10493949 (1), 11529681 (1), 15953420 (1), 10047984 (1) (see all 5)



    Find genes that share compounds with MYLK           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for MYLK gene (9 alternative transcripts): 
    NM_053025.3  NM_053026.3  NM_053027.3  NM_053028.3  NM_053031.2  NM_053032.2  NM_005965.3  NM_053029.2  
    NM_053030.2  

    Unigene Cluster for MYLK:

    Myosin light chain kinase
    Hs.477375  [show with all ESTs]
    Unigene Representative Sequence: NM_053025
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000360772(uc003egq.3 uc003egr.3) ENST00000418370(uc003egl.3 uc003egm.3)
    ENST00000578202 ENST00000464489 ENST00000346322 ENST00000583087 ENST00000475616
    ENST00000515434 ENST00000514895 ENST00000513111 ENST00000508240 ENST00000510775
    ENST00000511058 ENST00000504946(uc003egt.3) ENST00000503644 ENST00000514623
    ENST00000506361(uc010hrs.1) ENST00000510571(uc003egu.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MYLK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYLK (see all 57):
    hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-15a hsa-miR-503 hsa-miR-374a hsa-miR-519a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidMYLK 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MYLK
    Clone
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    OriGene clones in human, mouse for MYLK (see all 33)
    OriGene ORF clones in mouse, rat for MYLK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): MYLK (NM_053026)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYLK
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MYLK
    Addgene plasmids for MYLK 
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    OriGene qSTAR qPCR primer pairs in human, mouse for MYLK
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      QuantiTect SYBR Green Assays in human, mouse, rat MYLK
      QuantiFast Probe-based Assays in human, mouse, rat MYLK

    Additional mRNA sequence: 

    AB037663.1 AF069601.2 AF069602.1 AF069603.1 AF069604.1 AF096773.1 AF096774.1 AF096775.1 
    AF172084.1 AK025953.1 AK300610.1 AK311053.1 AK314412.1 AK314443.1 AY339601.1 AY424269.1 
    AY424270.1 BC015838.1 BC017811.1 BC034911.1 BC040115.1 BC062755.1 BC064420.1 BC064695.1 
    BC100761.2 BC100762.1 BC100763.1 BC107783.1 BC113456.1 BC113458.1 CR749364.1 DQ642691.1 
    DQ642692.1 U48959.2 X85337.1 X90870.1 Y09530.1 

    Selected DOTS entries (see all 36):

    DT.100828113  DT.75156952  DT.95207535  DT.95091526  DT.95219720  DT.92443576  DT.97783104  DT.91913964 
    DT.101985188  DT.95133686  DT.100828115  DT.91885779  DT.95177069  DT.95240559  DT.100044858  DT.101978684 
    DT.95091536  DT.97857523  DT.120894430  DT.120894445  DT.91906984  DT.100043607  DT.120894339  DT.120894342 

    Selected AceView cDNA sequences (see all 579):

    CD677637 BQ574143 AA099391 AI061263 NM_053029 R36785 AA374747 NM_053032 
    BU678146 AF096773 AI095622 BU680947 BM142220 NM_053026 AI769684 AA374700 
    CA412064 AA099392 NM_053028 BQ009110 BU683234 N80937 AA376021 AY339601 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MYLK (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c · 18d · 18e ^ 19 ^ 20a ·
    SP1:                                            -                                   -                                   -     -     -     -           -     -   
    SP2:                                                                                                                    -     -     -     -           -     -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                  -     -   

    ExUns: 20b · 20c · 20d ^ 21a · 21b · 21c ^ 22
    SP1:  -           -                           
    SP2:  -           -                           
    SP3:                                          
    SP4:                                          
    SP5:  -           -                           


    ECgene alternative splicing isoforms for MYLK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYLK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGGCGTAT
    MYLK Expression
    About this image


    MYLK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 24) fully expand
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Vascular Smooth Muscle Cells Aortic Arch Arteries
             Paraxial mesoderm-derived smooth muscle cells
     
     Endothelium (Cardiovascular System)
             Vascular Smooth Muscle Cells Veins
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Vascular Smooth Muscle Cells Splanchnic Mesoderm
     
     Heart (Cardiovascular System)
             Vascular Smooth Muscle Cells Aortic Arch Arteries
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
             Retina
    MYLK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYLK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.477375

    UniProtKB/Swiss-Prot: MYLK_HUMAN, Q15746
    Tissue specificity: Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal
    tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor
    development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. Telokin
    has been found in a wide variety of adult and fetal tissues. Accumulates in well differentiated enterocytes of
    the intestinal epithelium in response to tumor necrosis factor (TNF)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MYLK: 
              Hypertension in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Cell Motility in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYLK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MYLK gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mylk1 , 5 myosin, light polypeptide kinase1, 5 85.47(n)1
    85.54(a)1
      16 (24.49 cM)5
    1075891  NM_139300.31  NP_647461.31 
     347452105 
    chicken
    (Gallus gallus)
    Aves MYLK1 myosin light chain kinase 68.72(n)
    71.35(a)
      396445  NM_205459.2  NP_990790.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYLK6
    myosin light chain kinase
    63(a)
    1 ↔ 1
    1(78988152-79253423)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004896781 myosin light chain kinase, smooth muscle-like 54.69(n)
    48.44(a)
      100489678  XM_002935552.2  XP_002935598.2 
    zebrafish
    (Danio rerio)
    Actinopterygii CK029765.12   -- 73.09(n)    CK029765.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG17763 protein amino acid phosphorylation
    protein serine/threonine more
    48(a)
    (best of 2)
      46B2   --
    worm
    (Caenorhabditis elegans)
    Secernentea ZC373.43 calcium/calmodulin dependent protein
    kinase
    43(a)   X(10098022-10105019)   --


    ENSEMBL Gene Tree for MYLK (if available)
    TreeFam Gene Tree for MYLK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYLK gene
    STK17B2  DAPK22  MYLK22  TTN2  STK17A2  MYLK32  OBSCN2  DAPK32  
    SPEG2  MYLK42  DAPK12  
    Selected SIMAP similar genes for MYLK using alignment to 8 protein entries:     MYLK_HUMAN (see all proteins) (see all similar genes):
    DKFZp686I10125    MYLK4    DAPK2    DAPK3    STK17A    RPS6KA1
    STK17B    CAMK1G    CAMK1    CAMK1D    MARK4    MYOM1
    TTN    DKFZp564L2416    NEK6    CAMK2B    NUAK1    PRKY

    Find genes that share paralogs with MYLK           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for MYLK
    PGOHUM00000250243 PGOHUM00000238157 PGOHUM00000238160


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYLK (see all 5645)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0655774
    Aortic aneurysm, familial thoracic 7 (AAT7)4--see VAR_0655772 S P mis40--------
    VAR_0408594
    An ovarian mucinous carcinoma sample4--see VAR_0408592 P L mis40--------
    rs2000370581,2
    C--120724156(-) TCTCTC/TTTTTT 4 -- int10--------
    rs1448343661,2
    C--120726574(+) CTTTC-/TGTG  
            
    TGTGT
    4 -- int10--------
    rs2003718961,2
    C--120741932(+) GCTCT-/GGGGGG 4 -- spa10--------
    rs414419441,2
    C--120757231(-) CATCC-/ATCC  
            
    TGCCC
    4 -- int11Minor allele frequency- ATCC:0.00CSA 2
    rs1411565671,2
    C--120757232(+) GGGCA-/GGAT  
            
    GGATG
    4 -- int10--------
    rs670954231,2
    C--120764942(+) GGGAG-/GAGAGAG 4 -- int10--------
    rs2018389711,2
    C--120836776(+) ATTAAA/CTGATA 4 -- int10--------
    rs718552921,2
    C--120898754(+) TTTAT-/TTTTA 
            
    TTTTA
    4 -- int10--------

    HapMap Linkage Disequilibrium report for MYLK (123328896 - 123578896 bp, first 250kb of MYLK)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for MYLK:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2281404CNV Deletion18987734
    esv998431CNV Deletion20482838
    nsv3979CNV Insertion18451855
    nsv508946CNV Insertion20534489
    nsv460838CNV Loss19166990
    nsv829709CNV Loss17160897
    nsv829708CNV Gain17160897
    nsv829710CNV Gain17160897
    nsv460837CNV Gain19166990
    nsv518633CNV Gain19592680

    Human Gene Mutation Database (HGMD): MYLK
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYLK
    DNA2.0 Custom Variant and Variant Library Synthesis for MYLK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600922   
    OMIM disorders: 613780  
    UniProtKB/Swiss-Prot: MYLK_HUMAN, Q15746
  • Aortic aneurysm, familial thoracic 7 (AAT7) [MIM:613780]: A disease characterized by permanent dilation
    of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a
    characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which
    there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of
    basophilic ground substance. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 7 diseases for MYLK:    
    About MalaCards
    aortic aneurysm, familial thoracic 7    mylk-related thoracic aortic aneurysms and aortic dissections    intracranial vasospasm    aortic aneurysm, familial thoracic 4
    giardiasis    thoracic aortic aneurysms and aortic dissections    aortic aneurysm

    2 diseases from the University of Copenhagen DISEASES database for MYLK:
    Intracranial vasospasm     Asthma

    Find genes that share disorders with MYLK           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MYLK gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia telangiectasia 22.9 2 15941674 (1), 11016625 (1)
    carcinosarcoma 21.4 2 1457347 (1), 15950966 (1)
    asthma 12.2 9 18521921 (3), 17266121 (2)
    edema 11.5 7 19374788 (1)
    cholera 0 2 9572834 (1)
    sepsis 0 2 16399953 (2)
    necrosis 0 1 11384975 (1)
    shock 0 1 14968112 (1)
    metastasis 0 4 15970650 (3), 16606541 (1)
    tumors 0 6 15970650 (2), 16606541 (1), 20067998 (1), 11384975 (1) (see all 5)

    Genetic Association Database (GAD): MYLK
    Human Genome Epidemiology (HuGE) Navigator: MYLK (19 documents)

    Export disorders for MYLK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYLK gene, integrated from 10 sources (see all 272):
    (articles sorted by number of sources associating them with MYLK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21. (PubMed id 8575746)1, 2, 3, 9 Potier M.-C....Turnell W.G. (Genomics 1995)
    2. A single human myosin light chain kinase gene (MLCK; MYLK). (PubMed id 10198165)1, 2, 9 Lazar V.L. and Garcia J.G.N. (Genomics 1999)
    3. Myosin light chain kinase in endothelium: molecular cloning and regulation. (PubMed id 9160829)1, 2, 9 Garcia J.G.N....Verin A.D. (Am. J. Respir. Cell Mol. Biol. 1997)
    4. Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury. (PubMed id 16399953)1, 4, 9 Gao L....Garcia J.G. (Am. J. Respir. Cell Mol. Biol. 2006)
    5. Myosin light chain kinase modulates hypotonicity-induced Ca2+ entry and Cl- channel activity in human cervical cancer cells. (PubMed id 11976941)1, 2, 9 Shen M.-R.... Ellory J.C. (Pflugers Arch. 2002)
    6. Analysis of the kinase-related protein gene found at human chromosome 3q21 in a multi-gene cluster: organization, expression, alternative splicing and polymorphic marker. (PubMed id 10536370)1, 2, 9 Watterson D.M.... Haiech J. (J. Cell. Biochem. 1999)
    7. A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans. (PubMed id 17266121)1, 4, 9 Flores C....Garcia J.G. (Genet. Epidemiol. 2007)
    8. A common cortactin gene variation confers differential susceptibility to severe asthma. (PubMed id 18521921)1, 4, 9 Ma S.F....Garcia J.G. (Genet. Epidemiol. 2008)
    9. Novel interaction of cortactin with endothelial cell myosin light chain kinase. (PubMed id 12408982)1, 2, 9 Dudek S.M.... Garcia J.G.N. (Biochem. Biophys. Res. Commun. 2002)
    10. Differential regulation of alternatively spliced endothelial cell myosin light chain kinase isoforms by p60(Src). (PubMed id 11113114)1, 2, 9 Birukov K.G.... Garcia J.G.N. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4638 HGNC: 7590 AceView: MYLK Ensembl:ENSG00000065534 euGenes: HUgn4638
    ECgene: MYLK Kegg: 4638 H-InvDB: MYLK

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYLK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYLK Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Myosin_light-chain_kinase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYLK gene:
    Search GeneIP for patents involving MYLK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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