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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYLK Gene

protein-coding   GIFtS: 69
GCID: GC03M123281

myosin light chain kinase

(Previous names: myosin, light polypeptide kinase )
 Explore 26 diseases affiliated with
MYLK via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MYLK    

Aliases
for MYLK gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Myosin Light Chain Kinase1 2     AAT72
MLCK1 2 3 5     MLCK1082
MLCK11 2 3     MLCK2102
MYLK11 2 3     MSTP0832
SmMLCK1     Myosin Light Chain Kinase, Smooth Muscle2
Myosin, Light Polypeptide Kinase1 2     Smooth Muscle Myosin Light Chain Kinase2
Kinase-Related Protein2 3     Telokin3
KRP2 3     Telokin3
EC 2.7.11.183 8     EC 2.7.118

External Ids:    HGNC: 75901   Entrez Gene: 46382   Ensembl: ENSG000000655347   OMIM: 6009225   UniProtKB: Q157463   

Export aliases for MYLK gene to outside databases

Previous GC identifers: GC03M120053 GC03M124614 GC03M124653 GC03M124813 GC03M120704


Summaries
for MYLK gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MYLK:
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a
calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin
interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle
isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein
identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle
and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3.
Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as
well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full
length transcripts. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MYLK_HUMAN, Q15746
Function: Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via
phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity.
Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular
permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities
relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and
asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as
well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it
has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter
release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences
that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for
epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates
RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its
subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis.
PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil
transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in
mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional
actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the
development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction.
Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via
reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and
subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells.
Responsible for high proliferative ability of breast cancer cells through anti-apoptosis

summary for MYLK:
Myosin Light Chain Kinases (MLCKs) are a group of protein serine/threonine kinases that is currently divided
into two subtypes, MLCK1 and MLCK2. MLCK1 is found in smooth muscle and phosphorylates myosin II regulatory
light chains at Ser19, allowing myosin crossbridges to bind to actin filaments and initiate contraction. In
addition to smooth muscle contraction, MLCK1 is involved in a diverse range of biological processes
including control of endothelial and vascular permeability, growth initiation of astrocytes processes,
neurotransmitter release in the sympathetic nervous system and apoptosis of fibroblasts. MLCK2 is found in
striated muscle and co-localizes with phosphorylated MLC filaments to mediate skeletal and cardiac muscle
contraction. MLCK3 and MLCK4 have recently been identified but are yet to be fully characterized. MLCKs are
activated by Ca2+-calmodulin complexes and require Mg2+ or Ca2+ as a co-factor.

Gene Wiki entry for MYLK


Genomic Views
for MYLK gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYLK gene promoter:
         AML1a   p53   STAT5A   CUTL1   GATA-2   FOXJ2 (long isoform)   FOXO1a   FOXJ2   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MYLK promoter sequence
   Search SABiosciences Chromatin IP Primers for MYLK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYLK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21   Ensembl cytogenetic band:  3q21.1   HGNC cytogenetic band: 3q21

MYLK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYLK gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M123281:  view genomic region     (about GC identifiers)

Start:
 123,328,896 bp from pter      End:
 123,603,178 bp from pter
Size:
 274,283 bases      Orientation:
 minus strand

Proteins
for MYLK gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MYLK_HUMAN, Q15746 (See protein sequence)
Recommended Name: Myosin light chain kinase, smooth muscle  
Size: 1914 amino acids; 210715 Da
Cofactor: Magnesium
Cofactor: Calcium
Subunit: All isoforms including Telokin bind calmodulin. Interacts with SVIL (By similarity). Interacts with CTTN; this
interaction is reduced during thrombin-induced endothelial cell (EC) contraction but is promoted by the
barrier-protective agonist sphingosine 1-phosphate (S1P) within lamellipodia. A complex made of ABL1, CTTN and MYLK
regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated
endothelial cell (EC) barrier enhancement. Binds to NAA10/ARD1 and PTK2B/PYK2
Subcellular location: Cytoplasm. Cell projection, lamellipodium. Cleavage furrow. Cytoplasm, cytoskeleton.
Note=Localized to stress fibers during interphase and to the cleavage furrow during mitosis
Miscellaneous: In asthmatic patients, overexpression promotes actin filament propulsion, thus contributing to airway
hyperresponsiveness. Some MYLK variants may contribute to acute lung injury (ALI) susceptibility. Potential
therapeutic target in the treatment of burn edema
Sequence caution: Sequence=AAD15922.1; Type=Frameshift; Positions=1433; Sequence=AAD15923.1; Type=Frameshift;
Positions=1433; Sequence=AAD15924.1; Type=Frameshift; Positions=1433;
3 PDB 3D structures from and Proteopedia for MYLK:
2CQV (3D)        2K0F (3D)        2YR3 (3D)    
Secondary accessions: O95796 O95797 O95798 O95799 Q14844 Q16794 Q3ZCP9 Q5MY99 Q5MYA0 Q7Z4J0 Q9C0L5
Q9UBG5 Q9UBY6 Q9UIT9
Alternative splicing, Alternative initiation: 8 isoforms:  Q15746-1   Q15746-2   Q15746-3   Q15746-4   Q15746-5   Q15746-6   Q15746-7   Q15746-8   
(Produced by alternative initiation at Met-1761 of isoform 1. Has no catalytic activity)

Explore the universe of human proteins at neXtProt for MYLK: NX_Q15746

Post-translational modifications:

  • Can probably be down-regulated by phosphorylation. Tyrosine phosphorylation by ABL1 increases kinase activity, reverses
    • MLCK-mediated inhibition of Arp2/3-mediated actin polymerization, and enhances CTTN-binding. Phosphorylation by SRC at
    Tyr-464 and Tyr-471 promotes CTTN binding1
  • The C-terminus is deglutamylated by AGTPBP1/ CCP1, AGBL1/CCP4 and AGBL4/CCP6, leading to the formation of Myosin light
    • chain kinase, smooth muscle, deglutamylated form. The consequences of C-terminal deglutamylation are unknown (By
    similarity)1
  • Acetylated at Lys-608 by NAA10/ARD1 via a calcium-dependent signaling; this acetylation represses kinase activity and
    • reduces tumor cell migration1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15746

    • 4/18 DME Specific Peptides for MYLK (Q15746) (see all 18)
     SCQVTVD  SEEDVSQ  GKYTCEA  YTCKAVN 

    MYLK Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_444253.3  NP_444254.3  NP_444255.3  NP_444256.3  NP_444259.1  NP_444260.1  

    ENSEMBL proteins: 
     ENSP00000354004   ENSP00000428967   ENSP00000463691   ENSP00000417798   ENSP00000320622  
     ENSP00000462118   ENSP00000418335   ENSP00000422984   ENSP00000353452   ENSP00000352088  
     ENSP00000346846  
    Reactome Protein details: Q15746
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant MYLK Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MYLK
    OriGene Protein Over-expression Lysate: MYLK
    OriGene Custom Protein Services for MYLK 
    GenScript Custom Purified and Recombinant Proteins Services for MYLK
    Novus Biologicals MYLK Proteins
    Novus Biologicals MYLK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MYLK

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IDA15020676
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--
    GO:0030027lamellipodium IDA--


    MYLK for ontologies           About GeneDecksing



    MYLK Antibody Products: 
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    ThermoFisher Antibodies for MYLK

    Assay Products for MYLK: 
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    Uscn ELISAs and CLIAs for MYLK

    Protein Domains /
    Families
    for MYLK gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MYLK for domains           About GeneDecksing

    5/12 InterPro domains/families (see all 12):
     IPR003598 Ig_sub2
     IPR020675 Myosin_light_ch_kinase-rel
     IPR007110 Ig-like_dom
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q15746

    ProtoNet protein and cluster: Q15746

    1 Blocks protein family: IPB003962 Fibronectin type III repeat signature

    UniProtKB/Swiss-Prot: MYLK_HUMAN, Q15746
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 9 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 protein kinase domain


    Function
    for MYLK gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MYLK_HUMAN, Q15746
    Function: Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via
    phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity.
    Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular
    permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities
    relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and
    asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as
    well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it
    has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter
    release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences
    that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for
    epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates
    RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its
    subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis.
    PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil
    transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in
    mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional
    actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the
    development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction.
    Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via
    reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and
    subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells.
    Responsible for high proliferative ability of breast cancer cells through anti-apoptosis
    Catalytic activity: ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate
    Enzyme regulation: Isoform 1 is activated by phosphorylation on Tyr-464 and Tyr-471. Isoforms which lack these tyrosine
    residues are not regulated in this way. All catalytically active isoforms require binding to calcium and calmodulin
    for activation. Repressed by organometallic pyridylnaphthalimide complexes, wortmannin, ML-7 (a synthetic
    naphthalenesulphonyl derivative that inhibits the binding of ATP to MLCK) and ML-9
    Biophysicochemical properties: Kinetic parameters: KM=6.5 uM for MLC (isoform 1 at 22 degrees Celsius); KM=7.2 uM for
    MLC (isoform 2 at 22 degrees Celsius); Vmax=11.9 umol/min/mg enzyme (isoform 1 at 22 degrees Celsius); Vmax=10.9
    umol/min/mg enzyme (isoform 1 at 22 degrees Celsius);
    Induction: Accumulates in individuals with asthma (at protein levels). Induced by tumor necrosis factor (TNF).
    Repressed by androgens (e.g. R1881)

         Genatlas biochemistry entry for MYLK:
    myosin,light chain kinase,Ca2+/calmodulin dependent,expressed in smooth muscle and four non muscle isoforms,including a
    short isoform named telokin (KRP-kinase related protein),expressed noteworthy in neurons and glia,in liver,lung and
    kidney and endothelial cells (hippocampus,entorhinal and frontal cortex),stimulating myosin ATPase activity without
    phosphorylating myosin light chain

    Enzyme Numbers (IUBMB): EC 2.7.11.181 2 EC 2.7.112

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 6): MYLK
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYLK
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate MYLK (see all 57):
    hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-15a hsa-miR-503 hsa-miR-374a hsa-miR-519a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: MYLK 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYLK (see all 7)
    OriGene shRNA RFP: MYLK
    OriGene siRNA: MYLK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYLK

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MYLK

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYLK (see all 8)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYLK (see all 10)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): MYLK (NM_053026)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYLK
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MYLK 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MYLK
    LifeMap BioReagents: cell line associated with MYLK: PureStem Z11, Meso Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYLK

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004687myosin light chain kinase activity IDA16284075
    GO:0005515protein binding IPI17474147
    GO:0005516calmodulin binding IEA--


    MYLK for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for MYLK:
     Decreased substrate adherent c  Increased cell death in breast  Stronger migration  Upregulation of Wnt/beta-caten 
     Wnt reporter downregulated 

    Animal Models:
         Mouse knock-outs for MYLK: Mylktm1Avs Mylktm1Dmw
         11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Mylk):
     behavior/neurological  cardiovascular system  digestive/alimentary  growth/size  homeostasis/metabolism 
     immune system  mortality/aging  muscle  normal  renal/urinary system 
     skeleton 

    MYLK for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MYLK gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/24 super-pathways (see all 24) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_Integrin-mediated cell adhesion and migration
    		Cell adhesion_Integrin-mediated cell adhesion and migration1.00
    		Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    		Cell adhesion Integrin-mediated cell adhesion and migration1.00
    		Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases0.49
    2Immune response _CCR3 signaling in eosinophils
    		Immune response _CCR3 signaling in eosinophils1.00
    		Inhibitory action of Lipoxins on neutrophil migration0.51
    		Immune response CCR3 signaling in eosinophils1.00
    3Signal transduction_Activation of PKC via G-Protein coupled receptor
    		Signal transduction_Activation of PKC via G-Protein coupled receptor1.00
    		Signal transduction Activation of PKC via G-Protein coupled receptor0.98
    4Rho Family GTPases
    		Rho Family GTPases1.00
    		ERK Signaling0.61
    5Integrin Pathway
    		Integrin Pathway1.00
    		Transendothelial Migration of Leukocytes0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 EMD Millipore Pathways for MYLK
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils
    Signal transduction Activation of PKC via G-Protein coupled receptor

    5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYLK (see all 14)
        RhoA Pathway
    PKA Signaling
    Actin-Based Motility by Rho Family GTPases
    CDC42 Pathway
    Signaling Involved in Cardiac Hypertrophy

    5/6 GeneGo (Thomson Reuters) Pathways for MYLK (see all 6)
        Signal transduction Activation of PKC via G-Protein coupled receptor
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils

    5 BioSystems Pathways for MYLK 
        Focal Adhesion
    MicroRNAs in cardiomyocyte hypertrophy
    Endothelin
    Regulation of Actin Cytoskeleton
    Aurora B signaling

    2        Reactome Pathways for MYLK
        Smooth Muscle Contraction
    Muscle contraction


    5         Kegg Pathways  (Kegg details for MYLK):
        Calcium signaling pathway
    Vascular smooth muscle contraction
    Focal adhesion
    Regulation of actin cytoskeleton
    Gastric acid secretion


    MYLK for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MYLK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/71 Interacting proteins for MYLK (Q157461, 2, 3 ENSP000003534524) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-8112111 I2D: score=3 STRING: ENSP00000274335
    MYL12AP191052, 3, ENSP000002176524MINT-8150278 I2D: score=1 STRING: ENSP00000217652
    CALM1P621583, ENSP000003494674I2D: score=3 STRING: ENSP00000349467
    CALM2P621583I2D: score=3 
    CALM3P621583I2D: score=3 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS8575746
    GO:0006936muscle contraction TAS--
    GO:0006939smooth muscle contraction ISS--
    GO:0014820tonic smooth muscle contraction ISS--
    GO:0030335positive regulation of cell migration IDA19826488


    MYLK for ontologies           About GeneDecksing



    Drugs & Compounds
    for MYLK gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MYLK for compounds           About GeneDecksing

    EMD Millipore small molecules for MYLK:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for MYLK

    Compounds for MYLK available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ML 7 hydrochlorideSelective inhibitor of myosin light chain kinase[110448-33-4]
    ML 9 hydrochlorideMyosin light chain kinase inhibitor[105637-50-1]
    W-7 hydrochlorideCalmodulin antagonist. Inhibits myosin light chain kinase[61714-27-0]
    MLCK inhibitor peptideMyosin light chain kinase inhibitor[198694-74-5]
    MLCK inhibitor peptide 18Selective inhibitor of myosin light chain kinase[224579-74-2]

    4 HMDB Compounds for MYLK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    10/36 Novoseek chemical compound relationships for MYLK gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    blebbistatin 84 3 17925381 (1), 17412815 (1), 16672772 (1)
    kt 5926 80.1 9 10640419 (1), 8388002 (1), 1313815 (1), 9240372 (1) (see all 5)
    actomyosin 74.3 9 11606635 (2), 7611441 (1), 8409758 (1), 11062269 (1) (see all 6)
    calyculin a 65.7 3 9806741 (1)
    wortmannin 44.3 7 17093082 (2), 8555484 (1), 19160680 (1), 11304465 (1) (see all 5)
    fasudil 40.2 1 16299551 (1)
    threonine 40.1 3 10493949 (1), 11529681 (1), 10047984 (1)
    calcium 39.7 53 11976941 (5), 9506478 (4), 11346659 (4), 16051224 (3) (see all 24)
    2,3-butanedione monoxime 37.3 2 16672772 (1), 11807939 (1)
    serine 32.8 5 10493949 (1), 11529681 (1), 15953420 (1), 10047984 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about MYLK 

    Transcripts
    for MYLK gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MYLK gene (9 alternative transcripts): 
    NM_053025.3  NM_053026.3  NM_053027.3  NM_053028.3  NM_053031.2  NM_053032.2  NM_005965.3  NM_053029.2  
    NM_053030.2  

    Unigene Cluster for MYLK:

    Myosin light chain kinase
    Hs.477375  [show with all ESTs]
    Unigene Representative Sequence: NM_053025
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000360772(uc003egq.3 uc003egr.3) ENST00000418370(uc003egl.3 uc003egm.3)
    ENST00000578202 ENST00000464489 ENST00000346322 ENST00000583087 ENST00000475616
    ENST00000515434 ENST00000514895 ENST00000513111 ENST00000508240 ENST00000510775
    ENST00000511058 ENST00000504946(uc003egt.3) ENST00000503644 ENST00000514623
    ENST00000506361(uc010hrs.1) ENST00000510571(uc003egu.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 6): MYLK
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYLK
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate MYLK (see all 57):
    hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-15a hsa-miR-503 hsa-miR-374a hsa-miR-519a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: MYLK 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYLK (see all 7)
    OriGene shRNA RFP: MYLK
    OriGene siRNA: MYLK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYLK
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYLK (see all 10)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): MYLK (NM_053026)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYLK
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MYLK 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYLK

    Additional cDNA sequence: 

    AB037663.1 AF069601.2 AF069602.1 AF069603.1 AF069604.1 AF096773.1 AF096774.1 AF096775.1 
    AF172084.1 AK025953.1 AK300610.1 AK311053.1 AK314412.1 AK314443.1 AY339601.1 AY424269.1 
    AY424270.1 BC015838.1 BC017811.1 BC034911.1 BC040115.1 BC062755.1 BC064420.1 BC064695.1 
    BC100761.2 BC100762.1 BC100763.1 BC107783.1 BC113456.1 BC113458.1 CR749364.1 DQ642691.1 
    DQ642692.1 U48959.2 X85337.1 X90870.1 Y09530.1 

    24/35 DOTS entries (see all 35):

    DT.100828113  DT.75156952  DT.95207535  DT.95091526  DT.95219720  DT.92443576  DT.97783104  DT.91913964 
    DT.101985188  DT.95133686  DT.100828115  DT.91885779  DT.95177069  DT.100044858  DT.101978684  DT.95091536 
    DT.97857523  DT.120894430  DT.120894445  DT.91906984  DT.95240559  DT.100043607  DT.120894339  DT.120894342 

    24/579 AceView cDNA sequences (see all 579):

    AV708937 AI445644 CA391484 NM_053031 AA992497 CA775864 AI126911 BE856016 
    NM_005965 AI268755 AI659720 BQ006428 BX096726 CA443403 AF096775 BM510826 
    AV726977 CA432076 BU855752 BM985408 CA395228 BQ371152 CA406295 BQ128177 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for MYLK (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c · 18d · 18e ^ 19 ^ 20a ·
    SP1:                                            -                                   -                                   -     -     -     -           -     -   
    SP2:                                                                                                                    -     -     -     -           -     -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                  -     -   

    ExUns: 20b · 20c · 20d ^ 21a · 21b · 21c ^ 22
    SP1:  -           -                           
    SP2:  -           -                           
    SP3:                                          
    SP4:                                          
    SP5:  -           -                           


    ECgene alternative splicing isoforms for MYLK

    Expression
    for MYLK gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYLK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTGGCGTAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MYLK expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EndotheliumVeinsVascular Smooth Muscle CellsSmooth Muscle
    HeartAortic Arch ArteriesVascular Smooth Muscle CellsMyocardium, Neural Crest, Smooth Muscle
    HeartEndocardiumVascular Smooth Muscle CellsSmooth Muscle
    EyeInner Nuclear LayerType1 Off Cone Bipolar CellsBipolar, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Paraxial mesoderm-derived smooth muscle cells (Generation of human ...)

    See MYLK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYLK

    SOURCE GeneReport for Unigene cluster: Hs.477375

    UniProtKB/Swiss-Prot: MYLK_HUMAN, Q15746
    Tissue specificity: Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues
    and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific.
    Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. Telokin has been found in a wide
    variety of adult and fetal tissues. Accumulates in well differentiated enterocytes of the intestinal epithelium in
    response to tumor necrosis factor (TNF)

        SABiosciences Expression via Pathway-Focused PCR Arrays including MYLK: 
              Hypertension in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Cell Motility in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for MYLK gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MYLK gene from 4/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MYLK1 myosin light chain kinase 68.76(n)
    71.44(a)    		   396445  NM_205459.2  NP_990790.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MYLK6
    		 --
    		 64(a)
    		 1 ↔ 1
    		 1(79086324-79250647)
    zebrafish
    (Danio rerio)    		 Actinopterygii CK029765.12   -- 73.09(n)    CK029765.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG17763 protein amino acid phosphorylation protein
    serine/threonine more    		 48(a)
    (best of 2)    		   46B2   --


    ENSEMBL Gene Tree for MYLK (if available)
    TreeFam Gene Tree for MYLK (if available) 

    Paralogs
    for MYLK gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYLK gene
    STK17B2  DAPK22  MYLK22  TTN2  MYLK32  STK17A2  OBSCN2  DAPK32  
    SPEG2  MYLK42  DAPK12  OBSL12  
    18/47 SIMAP similar genes for MYLK using alignment to 11 protein entries:     MYLK_HUMAN (see all proteins) (see all similar genes):
    DKFZp686I10125    MYLK4    DAPK3    DAPK2    STK17A    RPS6KA1
    STK17B    STK32A    CAMK1G    CAMK1    CAMK1D    MARK4
    MYOM1    DKFZp564L2416    TTN    NEK6    CAMK2B    NUAK1

    MYLK for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for MYLK
    PGOHUM00000250243 PGOHUM00000238157 PGOHUM00000238160


    Genomic Variants
    for MYLK gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4699 NCBI SNPs in MYLK are shown (see all 4699)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs89831,2
    		C--120704217(+) AAGAAG/AGCATT 6 -- ut313Minor allele frequency- A:0.00MN NA 188
    rs789747571,2
    		F,--120704243(+) TATACG/ACCACA 6 -- ut311Minor allele frequency- A:0.02EA 120
    rs1167093531,2
    		C,F,--120704362(+) AACTGT/CGGCAA 6 -- ut311Minor allele frequency- C:0.09WA 118
    rs1130468891,2
    		--120704598(+) CTTACG/AAACAG 6 -- ut311Minor allele frequency- A:0.50CSA 2
    rs1120952731,2
    		--120704954(+) TTCTCC/TAGCTC 6 -- ut312Minor allele frequency- T:0.02CSA WA 120
    rs1159321051,2
    		C,F,--120705481(+) GGGTGG/AGGAGA 6 -- ut311Minor allele frequency- A:0.05WA 118
    rs1117298051,2
    		C--120705839(+) TTTTTC/G/TAGTTT 12 -- ut311CSA 1
    rs746255491,2
    		C,--120705841(+) TTTGAG/TTTTTA 6 -- ut310--------
    rs26975271,2
    		C,--120706376(-) CAACAT/GGTGTG 6 -- int12Minor allele frequency- G:0.03NA 122
    rs1133326841,2
    		C,--120706503(+) CTGTTG/TCTCAA 6 -- int10--------

    HapMap Linkage Disequilibrium report for MYLK (123328896 - 123578896 bp, first 250kb of MYLK)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MYLK: --
    Human Gene Mutation Database (HGMD): MYLK

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYLK
    DNA2.0 Custom Variant and Variant Library Synthesis for MYLK

    Disorders / Diseases
    for MYLK gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MYLK for disorders           About GeneDecksing

    OMIM gene information: 600922    OMIM disorders: --

    UniProtKB/Swiss-Prot: MYLK_HUMAN, Q15746
  • Defects in MYLK are the cause of familial aortic aneurysm thoracic type 7 (AAT7) [MIM:613780]. AAT7 is a
    • disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic
    wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim
    cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle
    cells, and an accumulation of basophilic ground substance

    20/26 diseases for MYLK (see all 26):    About MalaCards
    inclusion body myositis    intracranial vasospasm    ataxia telangiectasia    giardiasis
    myositis    essential hypertension    cholera    ataxia
    hypertension    sepsis    rabies    asthma
    esophageal carcinoma    cervical cancer    gingivitis    choroiditis
    esophagitis    cervicitis    lung cancer    prostate cancer

    10/12 Novoseek disease relationships for MYLK gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia telangiectasia 22.9 2 15941674 (1), 11016625 (1)
    carcinosarcoma 21.4 2 1457347 (1), 15950966 (1)
    asthma 12.2 9 18521921 (3), 17266121 (2)
    edema 11.5 7 19374788 (1)
    cholera 0 2 9572834 (1)
    sepsis 0 2 16399953 (2)
    necrosis 0 1 11384975 (1)
    shock 0 1 14968112 (1)
    metastasis 0 4 15970650 (3), 16606541 (1)
    tumors 0 6 15970650 (2), 16606541 (1), 20067998 (1), 11384975 (1) (see all 5)

    Genetic Association Database (GAD): MYLK
    Human Genome Epidemiology (HuGE) Navigator: MYLK (19 documents)

    Export disorders for MYLK gene to outside databases

    Publications
    for MYLK gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYLK gene, integrated from 9 sources (see all 265):
    (articles sorted by number of sources associating them with MYLK)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21. (PubMed id 8575746)1, 2, 3, 9 Potier M.-C....Turnell W.G. (1995)
    2. A single human myosin light chain kinase gene (MLCK; MYLK). (PubMed id 10198165)1, 2, 9 Lazar V.L. and Garcia J.G.N. (1999)
    3. Myosin light chain kinase in endothelium: molecular cloning and regulation. (PubMed id 9160829)1, 2, 9 Garcia J.G.N....Verin A.D. (1997)
    4. Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury. (PubMed id 16399953)1, 4, 9 Gao L....Garcia J.G. (2006)
    5. Myosin light chain kinase modulates hypotonicity-induced Ca2+ entry and Cl- channel activity in human cervical cancer cells. (PubMed id 11976941)1, 2, 9 Shen M.R....Ellory J.C. (2002)
    6. Analysis of the kinase-related protein gene found at human chromosome 3q21 in a multi-gene cluster: organization, expression, alternative splicing and polymorphic marker. (PubMed id 10536370)1, 2, 9 Watterson D.M.... Haiech J. (1999)
    7. Novel interaction of cortactin with endothelial cell myosin light chain kinase. (PubMed id 12408982)1, 2, 9 Dudek S.M....Garcia J.G. (2002)
    8. Differential regulation of alternatively spliced endothelial cell myosin light chain kinase isoforms by p60(Src). (PubMed id 11113114)1, 2, 9 Birukov K.G.... Garcia J.G.N. (2001)
    9. The angiotensin II type 1 receptor induces membrane b lebbing by coupling to Rho A, Rho kinase, and myosin light chain kinase. (PubMed id 20181817)1, 2 Godin C.M. and Ferguson S.S. (2010)
    10. Myosin light chain kinase is responsible for high pro liferative ability of breast cancer cells via anti-apoptosis involving p38 path way. (PubMed id 20453870)1, 2 Cui W.J....Ye L.H. (2010)

    External Searches for MYLK gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MYLK gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4638 HGNC: 7590 AceView: MYLK Ensembl:ENSG00000065534 euGenes: HUgn4638
    ECgene: MYLK Kegg: 4638 H-InvDB: MYLK

    Other Databases showing MYLK gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MYLK gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYLK Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Myosin_light-chain_kinase

    Intellectual Property
    for MYLK gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MYLK gene:
    Search GeneIP for patents involving MYLK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MYLK gene

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    About This Section

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     MYLK Proteins, Antibodies, CLIAs, and ELISAs
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    von Willebrand factor
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