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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYLIP Gene

protein-coding   GIFtS: 57
GCID: GC06P016129

Myosin Regulatory Light Chain Interacting Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Myosin Regulatory Light Chain Interacting Protein1 2 3     Cellular Modulator Of Immune Recognition (C-MIR)2
MIR2 3 5     E3 Ubiquitin-Protein Ligase MYLIP2
E3 Ubiquitin Ligase-Inducible Degrader Of The Low Density Lipoprotein
Receptor1 2
     Myosin Regulatory Light Chain-Interacting Protein2
Inducible Degrader Of The LDL-Receptor2 3     BZF13
IDOL2 3     EC 6.3.2.-3
Band 4.1 Superfamily Member BZF12     Idol3

External Ids:    HGNC: 211551   Entrez Gene: 291162   Ensembl: ENSG000000079447   OMIM: 6100825   UniProtKB: Q8WY643   

Export aliases for MYLIP gene to outside databases

Previous GC identifers: GC06P016237 GC06P016076


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYLIP Gene:
The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to
membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel
ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. (provided by
RefSeq, Jul 2008)

GeneCards Summary for MYLIP Gene: 
MYLIP (myosin regulatory light chain interacting protein) is a protein-coding gene. Diseases associated with MYLIP include brain stem glioma, and bubonic plague. GO annotations related to this gene include cytoskeletal protein binding and ubiquitin-protein ligase activity. An important paralog of this gene is MSN.

UniProtKB/Swiss-Prot: MYLIP_HUMAN, Q8WY64
Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of
myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family.
Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the
stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts
as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent
degradation of LDLR

Gene Wiki entry for MYLIP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYLIP gene promoter:
         Elk-1   Pbx1a   MEF-2   CUTL1   Tal-1beta   Evi-1   E47   MEF-2A   S8   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYLIP promoter sequence
   Search SABiosciences Chromatin IP Primers for MYLIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYLIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p23-p22.3   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p23-p22.3

MYLIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYLIP gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P016129:  view genomic region     (about GC identifiers)

Start:
16,129,317 bp from pter      End:
16,148,479 bp from pter
Size:
19,163 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MYLIP_HUMAN, Q8WY64 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MYLIP  
Size: 445 amino acids; 49910 Da
Subunit: Homodimer. Interacts with the E2 ubiquitin-conjugating enzyme, UBE2D1 (via RING-type zinc finger).
Interacts with myosin regulatory light chain (MRLC) and TMEM4
Subcellular location: Cytoplasm (Probable). Cell membrane; Peripheral membrane protein
Developmental stage: Expressed in fetal tissues and higher levels were detected in placenta and fetal lung
2 PDB 3D structures from and Proteopedia for MYLIP:
2YHN (3D)        2YHO (3D)    
Secondary accessions: Q5TIA4 Q9BU73 Q9NRL9 Q9UHE7
Alternative splicing: 2 isoforms:  Q8WY64-1   Q8WY64-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MYLIP: NX_Q8WY64

Explore proteomics data for MYLIP at MOPED 

Post-translational modifications:

  • UniProtKB: Autoubiquitinated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WY64

  • MYLIP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MYLIP Protein Expression
    REFSEQ proteins: NP_037394.2  
    ENSEMBL proteins: 
     ENSP00000349298   ENSP00000008686  

    Human Recombinant Protein Products for MYLIP: 
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    Cloud-Clone Corp. Proteins for MYLIP 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA10593918
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane IEA--
    GO:0019898extrinsic to membrane IEA--

    MYLIP for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/10 InterPro protein domains (see all 10):
     IPR019748 FERM_central
     IPR001841 Znf_RING
     IPR019750 Band_41_fam
     IPR000798 Ez/rad/moesin_like
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q8WY64

    ProtoNet protein and cluster: Q8WY64

    2 Blocks protein domains:
    IPB000299 Band 4.1 domain
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: MYLIP_HUMAN, Q8WY64
    Domain: The RING domain mediates ubiquitination and the neurite outgrowth inhibitory activity
    Domain: The FERM domain binds phospholipids and mediates lipoprotein receptors recognition at the plasma membrane
    through their cytoplasmic tails
    Domain: The RING-type zinc finger mediates the interaction with UBE2D E2 enzymes
    Similarity: Contains 1 FERM domain
    Similarity: Contains 1 RING-type zinc finger


    MYLIP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYLIP_HUMAN, Q8WY64
    Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of
    myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family.
    Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the
    stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts
    as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent
    degradation of LDLR
    Enzyme regulation: Can bind 1 iron ion per dimer. Iron binding seems to decrease LDLR degradation activity
    Induction: Expression is directly activated by NR1H2 and NR1H3. Expression is not dependent of the sterol-response
    element-binding proteins (SREBPs). Expression is indirectly induced by LDL

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA14550572
    GO:0005515protein binding IPI12826659
    GO:0008092cytoskeletal protein binding IDA10593918
    GO:0008270zinc ion binding IEA--
         
    MYLIP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MYLIP:
     Synthetic lethal with Ras 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidMYLIP 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: MYLIP_HUMAN, Q8WY64
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYLIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for MYLIP (Q8WY642, 3 ENSP000003492984) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTAPQ131262, 3, ENSP000003695194MINT-14705 MINT-14706 I2D: score=2 STRING: ENSP00000369519
    MYL12BO149503, ENSP000002375004I2D: score=2 STRING: ENSP00000237500
    UBE2D1P516683, ENSP000003630194I2D: score=1 STRING: ENSP00000363019
    LDLRP011303, ENSP000002524444I2D: score=1 STRING: ENSP00000252444
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement IMP10593918
    GO:0007399nervous system development IMP10593918
    GO:0010989negative regulation of low-density lipoprotein particle clearance IEA--
    GO:0016567protein ubiquitination IDA14550572
    GO:0031648protein destabilization IEA--

    MYLIP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MYLIP

    4 HMDB Compounds for MYLIP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about MYLIP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYLIP gene: 
    NM_013262.3  

    Unigene Cluster for MYLIP:

    Myosin regulatory light chain interacting protein
    Hs.484738  [show with all ESTs]
    Unigene Representative Sequence: NM_013262
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356840 ENST00000349606(uc003nbq.3 uc003nbr.3)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidMYLIP 3' UTR sequence
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    Additional mRNA sequence: 

    AF006003.1 AF187016.2 AF212221.1 AF258586.1 AJ420601.1 AK026739.1 AK074391.1 AK314648.1 
    BC002860.2 BT007055.1 

    10 DOTS entries:

    DT.316554  DT.416189  DT.91992252  DT.92429453  DT.121339284  DT.95201647  DT.121339282  DT.92429454 
    DT.99987776  DT.40241088 

    24/281 AceView cDNA sequences (see all 281):

    N33087 AI203613 AA732971 AI273479 AA991762 AW590494 BE464694 AI075029 
    AA173408 BT007055 BX103166 Z41402 AA843192 R68255 AA855121 BQ632435 
    BM783953 CB215581 BQ894070 AI188970 AI014397 BU753916 AW006705 AA703182 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MYLIP    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7
    SP1:                    -                             -     -                                 
    SP2:                                                  -                                       
    SP3:              -     -                                                                     
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for MYLIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYLIP expression in normal human tissues (normalized intensities)      MYLIP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGATGTTAAA
    MYLIP Expression
    About this image


    MYLIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Midbrain tegmentum
             brain/midbrain   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             cd8+ t cell   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             Ureter
             visceral organ   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   

    See MYLIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYLIP

    SOURCE GeneReport for Unigene cluster: Hs.484738

    UniProtKB/Swiss-Prot: MYLIP_HUMAN, Q8WY64
    Tissue specificity: Ubiquitously expressed

        SABiosciences Expression via Pathway-Focused PCR Array including MYLIP: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYLIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MYLIP gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mylip1 , 5 myosin regulatory light chain interacting protein1, 5 88.76(n)1
    96.18(a)1
      13 (21.88 cM)5
    2182031  NM_153789.31  NP_722484.21 
     453897425 
    chicken
    (Gallus gallus)
    Aves MYLIP1 myosin regulatory light chain interacting protein 80.67(n)
    91.69(a)
      420841  NM_001012561.1  NP_001012579.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYLIP6
    Uncharacterized protein
    90(a)
    1 ↔ 1
    4(58372670-58385955)
    African clawed frog
    (Xenopus laevis)
    Amphibia CB207912.12   -- 77.72(n)    CB207912.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY423020.12   -- 77.74(n)   335888  AY423020.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dnr11 defense repressor 1 46.58(n)
    36.34(a)
      37575  NM_137836.1  NP_611680.2 


    ENSEMBL Gene Tree for MYLIP (if available)
    TreeFam Gene Tree for MYLIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYLIP gene
    MSN2  FRMD4A2  FRMD4B2  NF22  RDX2  EZR2  

    MYLIP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/414 SNPs in MYLIP are shown (see all 414)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30712391,2
    C--16075770(+) ttttt-/T/TTTT
            
    gagac
    1 -- us2k1 trp31NA 2
    rs1510714561,2
    C--16127350(+) GATCCC/TTCCTT 1 -- us2k10--------
    rs1424051731,2
    --16127357(+) CCTTTC/TTTTTT 1 -- us2k10--------
    rs37573541,2
    C,F,A,H--16127407(-) TAGTGG/ACCTTT 1 -- us2k127Minor allele frequency- A:0.37EA NS NA WA CSA 3923
    rs1446307451,2
    --16127430(+) GACTCA/GTGAAG 1 -- us2k10--------
    rs1478652301,2
    --16127629(+) GACAGA/GTGAAG 1 -- us2k10--------
    rs1884709051,2
    --16127633(+) GATGAA/CGTAAG 1 -- us2k10--------
    rs1928514091,2
    --16127714(+) CTGTCA/GCCTAG 1 -- us2k10--------
    rs1418594711,2
    C--16127759(+) AGCCTC/TGAACT 1 -- us2k10--------
    rs1840291551,2
    --16127760(+) GCCTCA/GAACTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MYLIP (16129317 - 16148479 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MYLIP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv5209CNV Insertion18451855


    Human Gene Mutation Database (HGMD): MYLIP
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MYLIP
    DNA2.0 Custom Variant and Variant Library Synthesis for MYLIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610082    OMIM disorders: --

    6 diseases for MYLIP:    About MalaCards
    brain stem glioma    bubonic plague    plague    schizophrenia
    hepatitis    neuronitis


    MYLIP for disorders           About GeneDecksing

    Genetic Association Database (GAD): MYLIP
    Human Genome Epidemiology (HuGE) Navigator: MYLIP (5 documents)

    Export disorders for MYLIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYLIP gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with MYLIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. (PubMed id 10593918)1, 2, 3 Olsson P.-A.... Lindholm D. (1999)
    2. Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR. (PubMed id 14550572)1, 2, 9 Bornhauser B.C.... Lindholm D. (2003)
    3. Neuronal expression of the ERM-like protein MIR in rat brain and its localization to human chromosome 6. (PubMed id 11162443)1, 3, 9 Olsson P.A....Lindholm D. (2000)
    4. MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. (PubMed id 12826659)1, 2, 9 Bornhauser B.C.... Lindholm D. (2003)
    5. Genetic determinants of statin-induced low-density lip oprotein cholesterol reduction: the Justification for the Use of Statins in Prev ention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. (PubMed id 22331829)1, 4 Chasman D.I....Ridker P.M. (2012)
    6. FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors. (PubMed id 22109552)1, 2 Calkin A.C....Tontonoz P. (2011)
    7. The IDOL-UBE2D complex mediates sterol-dependent degr adation of the LDL receptor. (PubMed id 21685362)1, 2 Zhang L....Schwabe J.W. (2011)
    8. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. (PubMed id 20864672)1, 4 Waterworth D.M....Sandhu M.S. (2010)
    9. Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (2010)
    10. MicroRNAs and target site screening reveals a pre-mic roRNA-30e variant associated with schizophrenia. (PubMed id 20347265)1, 4 Xu Y....Liu P. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29116 HGNC: 21155 AceView: MYLIP Ensembl:ENSG00000007944 euGenes: HUgn29116
    ECgene: MYLIP H-InvDB: MYLIP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYLIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYLIP gene:
    Search GeneIP for patents involving MYLIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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