Aliases for MYLIP Gene
External Ids for MYLIP Gene
Previous GeneCards Identifiers for MYLIP Gene
The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. [provided by RefSeq, Jul 2008]
GeneCards Summary for MYLIP Gene
MYLIP (Myosin Regulatory Light Chain Interacting Protein) is a Protein Coding gene. Diseases associated with MYLIP include bubonic plague and brain stem cancer. GO annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is C1orf106.
UniProtKB/Swiss-Prot for MYLIP Gene
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.