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MYLIP Gene

protein-coding   GIFtS: 55
GCID: GC06P016129

Myosin Regulatory Light Chain Interacting Protein

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin Regulatory Light Chain Interacting Protein1 2 3     Cellular Modulator Of Immune Recognition (C-MIR)2
MIR2 3 5     E3 Ubiquitin-Protein Ligase MYLIP2
E3 Ubiquitin Ligase-Inducible Degrader Of The Low Density Lipoprotein
Receptor1 2
     Myosin Regulatory Light Chain-Interacting Protein2
Inducible Degrader Of The LDL-Receptor2 3     BZF13
IDOL2 3     EC 6.3.2.-3
Band 4.1 Superfamily Member BZF12     Idol3

External Ids:    HGNC: 211551   Entrez Gene: 291162   Ensembl: ENSG000000079447   OMIM: 6100825   UniProtKB: Q8WY643   

Export aliases for MYLIP gene to outside databases

Previous GC identifers: GC06P016237 GC06P016076


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYLIP Gene:
The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to
membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel
ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. (provided by
RefSeq, Jul 2008)

GeneCards Summary for MYLIP Gene:
MYLIP (myosin regulatory light chain interacting protein) is a protein-coding gene. GO annotations related to this gene include cytoskeletal protein binding and ubiquitin-protein ligase activity. An important paralog of this gene is MSN.

UniProtKB/Swiss-Prot: MYLIP_HUMAN, Q8WY64
Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of
myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family.
Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the
stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts
as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent
degradation of LDLR

Gene Wiki entry for MYLIP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYLIP gene promoter:
         Elk-1   Pbx1a   MEF-2   CUTL1   Tal-1beta   Evi-1   E47   MEF-2A   S8   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYLIP promoter sequence
   Search Chromatin IP Primers for MYLIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYLIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p23-p22.3   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p23-p22.3

MYLIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYLIP gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P016129:  view genomic region     (about GC identifiers)

Start:
16,129,317 bp from pter      End:
16,148,479 bp from pter
Size:
19,163 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MYLIP_HUMAN, Q8WY64 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MYLIP  
Size: 445 amino acids; 49910 Da
Subunit: Homodimer. Interacts with the E2 ubiquitin-conjugating enzyme, UBE2D1 (via RING-type zinc finger).
Interacts with myosin regulatory light chain (MRLC) and TMEM4
Developmental stage: Expressed in fetal tissues and higher levels were detected in placenta and fetal lung
2 PDB 3D structures from and Proteopedia for MYLIP:
2YHN (3D)        2YHO (3D)    
Secondary accessions: Q5TIA4 Q9BU73 Q9NRL9 Q9UHE7
Alternative splicing: 2 isoforms:  Q8WY64-1   Q8WY64-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MYLIP: NX_Q8WY64

Explore proteomics data for MYLIP at MOPED

Post-translational modifications: 

  • Autoubiquitinated1
  • Modification sites at neXtProt

  • See MYLIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037394.2  
    ENSEMBL proteins: 
     ENSP00000349298   ENSP00000008686  

    MYLIP Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MYLIP

     
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    antibodies-online proteins for MYLIP (4 products) 

     
    antibodies-online peptides for MYLIP

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    antibodies-online kits for MYLIP (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 10):
     IPR019748 FERM_central
     IPR001841 Znf_RING
     IPR019750 Band_41_fam
     IPR000798 Ez/rad/moesin_like
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q8WY64

    ProtoNet protein and cluster: Q8WY64

    2 Blocks protein domains:
    IPB000299 Band 4.1 domain
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: MYLIP_HUMAN, Q8WY64
    Domain: The RING domain mediates ubiquitination and the neurite outgrowth inhibitory activity
    Domain: The FERM domain binds phospholipids and mediates lipoprotein receptors recognition at the plasma membrane
    through their cytoplasmic tails
    Domain: The RING-type zinc finger mediates the interaction with UBE2D E2 enzymes
    Similarity: Contains 1 FERM domain
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with MYLIP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYLIP_HUMAN, Q8WY64
    Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of
    myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family.
    Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the
    stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts
    as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent
    degradation of LDLR
    Enzyme regulation: Can bind 1 iron ion per dimer. Iron binding seems to decrease LDLR degradation activity
    Induction: Expression is directly activated by NR1H2 and NR1H3. Expression is not dependent of the sterol-response
    element-binding proteins (SREBPs). Expression is indirectly induced by LDL

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA14550572
    GO:0005515protein binding IPI12826659
    GO:0008092cytoskeletal protein binding IDA10593918
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with MYLIP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MYLIP:
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MYLIP

    miRNA
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    miRTarBase miRNAs that target MYLIP:
    hsa-mir-340-5p (MIRT019627), hsa-mir-20b-5p (MIRT001783), hsa-mir-92a-3p (MIRT004091), hsa-mir-106a-5p (MIRT001838), hsa-mir-19b-3p (MIRT004066), hsa-mir-186-5p (MIRT045155), hsa-mir-93-5p (MIRT028071)

    Block miRNA regulation of human, mouse, rat MYLIP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYLIP (see all 51):
    hsa-miR-323-3p hsa-miR-3146 hsa-miR-875-5p hsa-miR-106a hsa-miR-25 hsa-miR-105 hsa-miR-548l hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidMYLIP 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYLIP_HUMAN, Q8WY64: Cytoplasm (Probable). Cell membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    cytoskeleton2
    nucleus2
    endosome1
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA10593918
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane IEA--
    GO:0019898extrinsic component of membrane IEA--

    Find genes that share ontologies with MYLIP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: MYLIP_HUMAN, Q8WY64
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including MYLIP: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MYLIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for MYLIP (Q8WY642, 3 ENSP000003492984) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTAPQ131262, 3, ENSP000003695194MINT-14705 MINT-14706 I2D: score=2 STRING: ENSP00000369519
    MYL12BO149503, ENSP000002375004I2D: score=2 STRING: ENSP00000237500
    UBE2D1P516683, ENSP000003630194I2D: score=1 STRING: ENSP00000363019
    LDLRP011303, ENSP000002524444I2D: score=1 STRING: ENSP00000252444
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement IMP10593918
    GO:0007399nervous system development IMP10593918
    GO:0010989negative regulation of low-density lipoprotein particle clearance IEA--
    GO:0016567protein ubiquitination IDA14550572
    GO:0031648protein destabilization IEA--

    Find genes that share ontologies with MYLIP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYLIP

    4 HMDB Compounds for MYLIP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYLIP gene: 
    NM_013262.3  

    Unigene Cluster for MYLIP:

    Myosin regulatory light chain interacting protein
    Hs.484738  [show with all ESTs]
    Unigene Representative Sequence: NM_013262
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356840 ENST00000349606(uc003nbq.3 uc003nbr.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MYLIP (see all 51):
    hsa-miR-323-3p hsa-miR-3146 hsa-miR-875-5p hsa-miR-106a hsa-miR-25 hsa-miR-105 hsa-miR-548l hsa-miR-124
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    Additional mRNA sequence: 

    AF006003.1 AF187016.2 AF212221.1 AF258586.1 AJ420601.1 AK026739.1 AK074391.1 AK314648.1 
    BC002860.2 BT007055.1 

    10 DOTS entries:

    DT.316554  DT.416189  DT.91992252  DT.92429453  DT.121339284  DT.95201647  DT.121339282  DT.92429454 
    DT.99987776  DT.40241088 

    Selected AceView cDNA sequences (see all 281):

    AA360102 BT007055 BC002860 NM_013262 BM998138 BQ668520 AI204473 AA855121 
    AA703182 N33087 AI084066 BF515801 AW590494 BE351038 BE672457 BG576686 
    BG403680 BU753916 AI432464 AI014397 Z41402 AI188970 AA487191 AI161170 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MYLIP    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7
    SP1:                    -                             -     -                                 
    SP2:                                                  -                                       
    SP3:              -     -                                                                     
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for MYLIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYLIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGATGTTAAA
    MYLIP Expression
    About this image


    MYLIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Thymus
     
     Kidney (Urinary System)
             Metanephros
     
     Lower Urinary Tract (Urinary System)
             Ureter
    MYLIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYLIP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.484738

    UniProtKB/Swiss-Prot: MYLIP_HUMAN, Q8WY64
    Tissue specificity: Ubiquitously expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including MYLIP: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYLIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MYLIP gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mylip1 , 5 myosin regulatory light chain interacting protein1, 5 88.76(n)1
    96.18(a)1
      13 (21.88 cM)5
    2182031  NM_153789.31  NP_722484.21 
     453897425 
    chicken
    (Gallus gallus)
    Aves MYLIP1 myosin regulatory light chain interacting protein 80.67(n)
    91.69(a)
      420841  NM_001012561.1  NP_001012579.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYLIP6
    myosin regulatory light chain interacting protein
    90(a)
    1 ↔ 1
    4(58372670-58385955)
    African clawed frog
    (Xenopus laevis)
    Amphibia CB207912.12   -- 77.72(n)    CB207912.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY423020.12   -- 77.74(n)   335888  AY423020.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dnr11 defense repressor 1 47.44(n)
    36.88(a)
      37575  NM_137836.2  NP_611680.2 
    worm
    (Caenorhabditis elegans)
    Secernentea nfm-16
    Protein NFM-1, isoform a
    12(a)
    1 ↔ 1
    III(6159842-6164573) WBGene00003593


    ENSEMBL Gene Tree for MYLIP (if available)
    TreeFam Gene Tree for MYLIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYLIP gene
    MSN2  FRMD4A2  FRMD4B2  NF22  RDX2  EZR2  C1orf1062  

    Find genes that share paralogs with MYLIP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYLIP (see all 414)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30712391,2
    C--16075770(+) ttttt-/T/TTTT
            
    gagac
    1 -- us2k1 trp31NA 2
    rs1510714561,2
    C--16127350(+) GATCCC/TTCCTT 1 -- us2k10--------
    rs1424051731,2
    --16127357(+) CCTTTC/TTTTTT 1 -- us2k10--------
    rs37573541,2
    C,F,A,H--16127407(-) TAGTGG/ACCTTT 1 -- us2k127Minor allele frequency- A:0.37EA NS NA WA CSA 3923
    rs1446307451,2
    --16127430(+) GACTCA/GTGAAG 1 -- us2k10--------
    rs1478652301,2
    --16127629(+) GACAGA/GTGAAG 1 -- us2k10--------
    rs1884709051,2
    --16127633(+) GATGAA/CGTAAG 1 -- us2k10--------
    rs1928514091,2
    --16127714(+) CTGTCA/GCCTAG 1 -- us2k10--------
    rs1418594711,2
    C--16127759(+) AGCCTC/TGAACT 1 -- us2k10--------
    rs1840291551,2
    --16127760(+) GCCTCA/GAACTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MYLIP (16129317 - 16148479 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MYLIP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5209CNV Insertion18451855

    Human Gene Mutation Database (HGMD): MYLIP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYLIP
    DNA2.0 Custom Variant and Variant Library Synthesis for MYLIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610082    OMIM disorders: --


    Find genes that share disorders with MYLIP           About GenesLikeMe

    Genetic Association Database (GAD): MYLIP
    Human Genome Epidemiology (HuGE) Navigator: MYLIP (5 documents)

    Export disorders for MYLIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYLIP gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with MYLIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. (PubMed id 10593918)1, 2, 3 Olsson P.-A.... Lindholm D. (J. Biol. Chem. 1999)
    2. Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR. (PubMed id 14550572)1, 2, 9 Bornhauser B.C.... Lindholm D. (FEBS Lett. 2003)
    3. Neuronal expression of the ERM-like protein MIR in rat brain and its localization to human chromosome 6. (PubMed id 11162443)1, 3, 9 Olsson P.A....Lindholm D. (Biochem. Biophys. Res. Commun. 2000)
    4. MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. (PubMed id 12826659)1, 2, 9 Bornhauser B.C.... Lindholm D. (J. Biol. Chem. 2003)
    5. Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. (PubMed id 22331829)1, 4 Chasman D.I....Ridker P.M. (Circ Cardiovasc Genet 2012)
    6. FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors. (PubMed id 22109552)1, 2 Calkin A.C....Tontonoz P. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    7. The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. (PubMed id 21685362)1, 2 Zhang L.... Schwabe J.W. (Genes Dev. 2011)
    8. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. (PubMed id 20864672)1, 4 Waterworth D.M....Sandhu M.S. (Arterioscler. Thromb. Vasc. Biol. 2010)
    9. Biological, clinical and population relevance of 95 loci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (Nature 2010)
    10. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PubMed id 20347265)1, 4 Xu Y....Liu P. (Schizophr. Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29116 HGNC: 21155 AceView: MYLIP Ensembl:ENSG00000007944 euGenes: HUgn29116
    ECgene: MYLIP H-InvDB: MYLIP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYLIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYLIP gene:
    Search GeneIP for patents involving MYLIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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