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Aliases for MYLIP Gene

Aliases for MYLIP Gene

  • Myosin Regulatory Light Chain Interacting Protein 2 3 4 5
  • E3 Ubiquitin Ligase-Inducible Degrader Of The Low Density Lipoprotein Receptor 2 3
  • Inducible Degrader Of The LDL-Receptor 3 4
  • IDOL 3 4
  • MIR 3 4
  • Myosin Regulatory Light Chain-Interacting Protein 3
  • Cellular Modulator Of Immune Recognition (C-MIR) 3
  • Band 4.1 Superfamily Member BZF1 3
  • EC 6.3.2.- 4
  • BZF1 4

External Ids for MYLIP Gene

Previous GeneCards Identifiers for MYLIP Gene

  • GC06P016237
  • GC06P016076

Summaries for MYLIP Gene

Entrez Gene Summary for MYLIP Gene

  • The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYLIP Gene

MYLIP (Myosin Regulatory Light Chain Interacting Protein) is a Protein Coding gene. Diseases associated with MYLIP include Bubonic Plague and Brain Stem Cancer. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is C1orf106.

UniProtKB/Swiss-Prot for MYLIP Gene

  • E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

Gene Wiki entry for MYLIP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYLIP Gene

Genomics for MYLIP Gene

Regulatory Elements for MYLIP Gene

Enhancers for MYLIP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MYLIP on UCSC Golden Path with GeneCards custom track

Promoters for MYLIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MYLIP on UCSC Golden Path with GeneCards custom track

Genomic Location for MYLIP Gene

Chromosome:
6
Start:
16,129,086 bp from pter
End:
16,148,248 bp from pter
Size:
19,163 bases
Orientation:
Plus strand

Genomic View for MYLIP Gene

Genes around MYLIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYLIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYLIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYLIP Gene

Proteins for MYLIP Gene

  • Protein details for MYLIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WY64-MYLIP_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MYLIP
    Protein Accession:
    Q8WY64
    Secondary Accessions:
    • Q5TIA4
    • Q9BU73
    • Q9NRL9
    • Q9UHE7

    Protein attributes for MYLIP Gene

    Size:
    445 amino acids
    Molecular mass:
    49910 Da
    Quaternary structure:
    • Homodimer. Interacts with the E2 ubiquitin-conjugating enzyme, UBE2D1 (via RING-type zinc finger). Interacts with myosin regulatory light chain (MRLC) and TMEM4.

    Three dimensional structures from OCA and Proteopedia for MYLIP Gene

    Alternative splice isoforms for MYLIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYLIP Gene

Proteomics data for MYLIP Gene at MOPED

Post-translational modifications for MYLIP Gene

Other Protein References for MYLIP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYLIP Gene

Domains & Families for MYLIP Gene

Suggested Antigen Peptide Sequences for MYLIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WY64

UniProtKB/Swiss-Prot:

MYLIP_HUMAN :
  • The RING domain mediates ubiquitination and the neurite outgrowth inhibitory activity.
  • Contains 1 RING-type zinc finger.
Domain:
  • The RING domain mediates ubiquitination and the neurite outgrowth inhibitory activity.
  • The FERM domain binds phospholipids and mediates lipoprotein receptors recognition at the plasma membrane through their cytoplasmic tails.
  • The RING-type zinc finger mediates the interaction with UBE2D E2 enzymes.
  • Contains 1 FERM domain.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with MYLIP: view

No data available for Gene Families for MYLIP Gene

Function for MYLIP Gene

Molecular function for MYLIP Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Can bind 1 iron ion per dimer. Iron binding seems to decrease LDLR degradation activity.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
UniProtKB/Swiss-Prot Induction:
Expression is directly activated by NR1H2 and NR1H3. Expression is not dependent of the sterol-response element-binding proteins (SREBPs). Expression is indirectly induced by LDL.

Enzyme Numbers (IUBMB) for MYLIP Gene

Gene Ontology (GO) - Molecular Function for MYLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with MYLIP: view
genes like me logo Genes that share phenotypes with MYLIP: view

Animal Models for MYLIP Gene

MGI Knock Outs for MYLIP:

Animal Model Products

  • Taconic Biosciences Mouse Models for MYLIP

miRNA for MYLIP Gene

miRTarBase miRNAs that target MYLIP

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYLIP Gene

Localization for MYLIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYLIP Gene

Cytoplasm. Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYLIP Gene COMPARTMENTS Subcellular localization image for MYLIP gene
Compartment Confidence
cytosol 3
plasma membrane 3
cytoskeleton 2
extracellular 2
lysosome 2
nucleus 2
vacuole 2
endosome 1

No data available for Gene Ontology (GO) - Cellular Components for MYLIP Gene

Pathways & Interactions for MYLIP Gene

genes like me logo Genes that share pathways with MYLIP: view

UniProtKB/Swiss-Prot Q8WY64-MYLIP_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MYLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IDA 14550572
GO:0031648 protein destabilization IEA --
GO:0032803 regulation of low-density lipoprotein particle receptor catabolic process IEA --
genes like me logo Genes that share ontologies with MYLIP: view

No data available for SIGNOR curated interactions for MYLIP Gene

Drugs & Compounds for MYLIP Gene

(4) Drugs for MYLIP Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
atorvastatin Approved Pharma Competitive, Inhibitor 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for MYLIP Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with MYLIP: view

Transcripts for MYLIP Gene

mRNA/cDNA for MYLIP Gene

Unigene Clusters for MYLIP Gene

Myosin regulatory light chain interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYLIP Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7
SP1: - - -
SP2: -
SP3: - -
SP4:
SP5:

Relevant External Links for MYLIP Gene

GeneLoc Exon Structure for
MYLIP
ECgene alternative splicing isoforms for
MYLIP

Expression for MYLIP Gene

mRNA expression in normal human tissues for MYLIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MYLIP Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYLIP Gene



SOURCE GeneReport for Unigene cluster for MYLIP Gene Hs.484738

mRNA Expression by UniProt/SwissProt for MYLIP Gene

Q8WY64-MYLIP_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with MYLIP: view

Protein tissue co-expression partners for MYLIP Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for MYLIP Gene

Orthologs for MYLIP Gene

This gene was present in the common ancestor of animals.

Orthologs for MYLIP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYLIP 35
  • 88.86 (n)
  • 94.47 (a)
MYLIP 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYLIP 35
  • 89.5 (n)
  • 96.15 (a)
MYLIP 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mylip 35
  • 88.76 (n)
  • 96.18 (a)
Mylip 16
Mylip 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYLIP 35
  • 99.78 (n)
  • 99.78 (a)
MYLIP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mylip 35
  • 90.56 (n)
  • 96.4 (a)
oppossum
(Monodelphis domestica)
Mammalia MYLIP 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYLIP 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYLIP 35
  • 80.67 (n)
  • 91.69 (a)
MYLIP 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYLIP 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mylip 35
  • 76.33 (n)
  • 82.47 (a)
Str.8061 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
mylipa 35
  • 69.5 (n)
  • 77.47 (a)
mylipa 36
  • 71 (a)
OneToMany
mylipb 36
  • 62 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001609 35
  • 49.53 (n)
  • 39.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta dnr1 35
  • 47.44 (n)
  • 36.88 (a)
dnr1 36
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nfm-1 36
  • 12 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9403 36
  • 35 (a)
OneToOne
Species with no ortholog for MYLIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYLIP Gene

ENSEMBL:
Gene Tree for MYLIP (if available)
TreeFam:
Gene Tree for MYLIP (if available)

Paralogs for MYLIP Gene

Paralogs for MYLIP Gene

genes like me logo Genes that share paralogs with MYLIP: view

Variants for MYLIP Gene

Sequence variations from dbSNP and Humsavar for MYLIP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs9370867 - 16,145,094(+) AAGAA(A/G)CAACC reference, missense
rs1011616 -- 16,132,178(-) TCCAA(A/G)CTTCT intron-variant
rs1060901 -- 16,145,242(+) TGCTG(C/T)GAGGA reference, synonymous-codon
rs1060913 -- 16,146,509(+) GAGAC(A/G)GCAAA intron-variant
rs1076632 -- 16,129,469(+) TCGCA(A/G)CGACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYLIP Gene

Variant ID Type Subtype PubMed ID
nsv5209 CNV Insertion 18451855

Variation tolerance for MYLIP Gene

Residual Variation Intolerance Score: 31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYLIP Gene

Human Gene Mutation Database (HGMD)
MYLIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYLIP Gene

Disorders for MYLIP Gene

MalaCards: The human disease database

(3) MalaCards diseases for MYLIP Gene - From: DISEASES

Disorder Aliases PubMed IDs
bubonic plague
  • black death
brain stem cancer
  • malignant neoplasm of brain stem
brain stem glioma
  • brainstem neuroglial tumor
- elite association - COSMIC cancer census association via MalaCards
Search MYLIP in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYLIP

Genetic Association Database (GAD)
MYLIP
Human Genome Epidemiology (HuGE) Navigator
MYLIP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYLIP
genes like me logo Genes that share disorders with MYLIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYLIP Gene

Publications for MYLIP Gene

  1. MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. (PMID: 10593918) Olsson P.-A. … Lindholm D. (J. Biol. Chem. 1999) 2 3 4 67
  2. Neuronal expression of the ERM-like protein MIR in rat brain and its localization to human chromosome 6. (PMID: 11162443) Olsson P.A. … Lindholm D. (Biochem. Biophys. Res. Commun. 2000) 2 3 23
  3. Mylip makes an Idol turn into regulation of LDL receptor. (PMID: 19688294) Lindholm D. … Korhonen L. (Cell. Mol. Life Sci. 2009) 2 3
  4. MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. (PMID: 12826659) Bornhauser B.C. … Lindholm D. (J. Biol. Chem. 2003) 3 23
  5. Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR. (PMID: 14550572) Bornhauser B.C. … Lindholm D. (FEBS Lett. 2003) 3 23

Products for MYLIP Gene

Sources for MYLIP Gene

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