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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MYL9 Gene

protein-coding GIFtS: 61
GCID: GC20P035169

myosin, light chain 9, regulatory

(Previous names: myosin, light polypeptide 9, regulatory )

Explore 4 diseases affiliated with
MYL9 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Myosin, Light Chain 9, Regulatory¹ ²		Myosin Regulatory Light Chain 9² ³
MLC2¹ ² ³ ⁵		Myosin Regulatory Light Chain MRLC1² ³
LC20¹ ² ³		Myosin RLC² ³
MRLC1¹ ² ³		20 KDa Myosin Light Chain² ³
MYRL2¹ ² ³		MLC-2C² ³
Myosin, Light Polypeptide 9, Regulatory¹ ²		Myosin Regulatory Light Chain 1²
Myosin Regulatory Light Chain 2, Smooth Muscle Isoform² ³		Myosin Regulatory Light Polypeptide 9²

External Ids:	HGNC: 15754¹	Entrez Gene: 10398²	Ensembl: ENSG00000101335⁷	OMIM: 609905⁵	UniProtKB: P24844³

Export aliases for MYL9 gene to outside databases

Previous GC identifers: GC20P034898 GC20P035808 GC20P035855 GC20P034603 GC20P031906

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYL9:

Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by

this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin

heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants

encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MYL9_HUMAN, P24844

Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell

contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion

summary for MYL9:

Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding

and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),

almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain

that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts

with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory

myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.

Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is

involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a

contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by

intracellular Ca2+ concentrations.

Gene Wiki entry for MYL9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MYL9 gene promoter:
p53 MyoD Pax-2 Olf-1 XBP-1 Pax-2a Tal-1beta Gfi-1 GATA-1 E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MYL9 promoter sequence

Search SABiosciences Chromatin IP Primers for MYL9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYL9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23 Ensembl cytogenetic band: 20q11.23 HGNC cytogenetic band: 20q11.23

MYL9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL9 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P035169: view genomic region (about GC identifiers)

Start:	35,169,887 bp from pter	End:	35,178,228 bp from pter
Size:	8,342 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MYL9_HUMAN, P24844 (See protein sequence)

Recommended Name: Myosin regulatory light polypeptide 9

Size: 172 amino acids; 19827 Da

Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains

Miscellaneous: This chain binds calcium

Secondary accessions: E1P5T6 Q9BQL9 Q9BUF9 Q9H136

Alternative splicing: 2 isoforms: P24844-1 P24844-2

Explore the universe of human proteins at neXtProt for MYL9: NX_P24844

Post-translational modifications:

Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It

is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2

at the leading edge (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P24844

MYL9 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_006088.2 NP_852667.1

ENSEMBL proteins:

ENSP00000279022 ENSP00000217313

Reactome Protein details: P24844
Human Recombinant Protein Products:

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	Novus Biologicals MYL9 Proteins Novus Biologicals MYL9 Lysates
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	ProSpec Recombinant Protein for MYL9
	Uscn Proteins for MYL9

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001725	stress fiber	IEA	--
GO:0005829	cytosol	TAS	--
GO:0005859	muscle myosin complex	TAS	2526655
GO:0016460	myosin II complex	--	--
GO:0030018	Z disc	IEA	--

MYL9 for ontologies About GeneDecksing

MYL9 Antibody Products:

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	Uscn ELISAs and CLIAs for MYL9

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MYL9 for domains About GeneDecksing

3 InterPro domains/families:

IPR018247 EF_Hand_1_Ca_BS

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

Graphical View of Domain Structure for InterPro Entry P24844

ProtoNet protein and cluster: P24844

UniProtKB/Swiss-Prot: MYL9_HUMAN, P24844

Similarity: Contains 3 EF-hand domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MYL9_HUMAN, P24844

Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell

contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion

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		hsa-miR-663 hsa-miR-491-5p hsa-miR-1908
		SwitchGear 3'UTR luciferase reporter plasmid: MYL9 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL9

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0008307	structural constituent of muscle	TAS	2526655

MYL9 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/29 super-pathways (see all 29) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_Integrin-mediated cell adhesion and migration

	Cell adhesion_Integrin-mediated cell adhesion and migration	1.00			Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases	0.49
	Cell adhesion Integrin-mediated cell adhesion and migration	1.00			Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases	0.49

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

Immune response _CCR3 signaling in eosinophils

	Immune response _CCR3 signaling in eosinophils	1.00			Inhibitory action of Lipoxins on neutrophil migration	0.51
	Immune response CCR3 signaling in eosinophils	1.00

Striated Muscle Contraction

	Striated Muscle Contraction	1.00			Smooth Muscle Contraction	0.11
	Muscle contraction	0.65

Actin Nucleation by ARP-WASP Complex

	Actin Nucleation by ARP-WASP Complex	1.00			CDC42 Pathway	0.34
	RhoA Pathway	0.35

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for MYL9

	Cell adhesion Integrin-mediated cell adhesion and migration
	Cell adhesion Tight junctions
	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
	Immune response CCR3 signaling in eosinophils
	Development MAG-dependent inhibition of neurite outgrowth

5/25 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYL9 (see all 25)

	RhoA Pathway
	PKA Signaling
	Actin-Based Motility by Rho Family GTPases
	Guidance Cues and Growth Cone Motility
	Antioxidant Action of Vitamin-C

1 Cell Signaling Technology (CST) Pathway for MYL9

Cytoskeletal Signaling

5/6 GeneGo (Thomson Reuters) Pathways for MYL9 (see all 6)

	Cell adhesion Integrin-mediated cell adhesion and migration
	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
	Inhibitory action of Lipoxins on neutrophil migration
	Immune response CCR3 signaling in eosinophils
	Cell adhesion Tight junctions

1 BioSystems Pathway for MYL9

Striated Muscle Contraction

5/7 Reactome Pathways for MYL9 (see all 7)

	Developmental Biology
	Sema4D induced cell migration and growth-cone collapse
	Semaphorin interactions
	Smooth Muscle Contraction
	Muscle contraction

5 Kegg Pathways (Kegg details for MYL9):

	Vascular smooth muscle contraction
	Focal adhesion
	Tight junction
	Leukocyte transendothelial migration
	Regulation of actin cytoskeleton

MYL9 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MYL9

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/44 Interacting proteins for MYL9 (P24844³ ENSP00000279022⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 44)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDC42BPA	Q5VT25³, ENSP00000355731⁴	I2D: score=1 STRING: ENSP00000355731
TP53	P04637³, ENSP00000269305⁴	I2D: score=1 STRING: ENSP00000269305
TP63	Q9H3D4³, ENSP00000264731⁴	I2D: score=1 STRING: ENSP00000264731
TP73	O15350³, ENSP00000367545⁴	I2D: score=1 STRING: ENSP00000367545
MYH9	P35579³, ENSP00000216181⁴	I2D: score=3 STRING: ENSP00000216181

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006936	muscle contraction	TAS	--
GO:0006937	regulation of muscle contraction	TAS	2526655
GO:0007411	axon guidance	TAS	--

MYL9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MYL9 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for MYL9 available from Tocris Bioscience About this table

Compound	Action	CAS #
(R)-(+)-Blebbistatin	Selective inhibitor of myosin II. Inactive enantiomer of (�)-blebbistatin (Cat. No. 1760)	--
(S)-(-)-Blebbistatin	Selective inhibitor of myosin II. Active enantiomer of (�)-blebbistatin (Cat. No. 1760)	[856925-71-8]
(�)-Blebbistatin	Selective inhibitor of myosin II	[674289-55-5]

1 HMDB Compound for MYL9 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

4 Novoseek chemical compound relationships for MYL9 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
actomyosin	69.4	4	7611441 (1), 20089714 (1), 7767885 (1)
okadaic acid	37.9	1	1421576 (1)
isoproterenol	21.3	1	1512034 (1)
calcium	17.3	9	2244912 (2), 9217870 (1), 16076902 (1), 17200564 (1)

Search CenterWatch for drugs/clinical trials and news about MYL9

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MYL9 gene (2 alternative transcripts):

NM_006097.4 NM_181526.2

Unigene Cluster for MYL9:

Myosin, light chain 9, regulatory

Hs.504687 [show with all ESTs]

Unigene Representative Sequence: BM473095

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000279022(uc002xfl.1 uc002xfm.1) ENST00000346786

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYL9
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		hsa-miR-663 hsa-miR-491-5p hsa-miR-1908
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Additional cDNA sequence:

AF176042.1 AF176043.1 AK130879.1 BC002648.2 CR456843.1 D82057.1 J02854.1

24/27 DOTS entries (see all 27):

DT.95286486 DT.455515 DT.100773731 DT.120811100 DT.95373669 DT.100813209 DT.100813208 DT.102839074

DT.91724841 DT.100813210 DT.95373678 DT.92454181 DT.95069319 DT.95373679 DT.120811007 DT.95365419

DT.120811033 DT.40107721 DT.75186726 DT.92454202 DT.100813205 DT.100813206 DT.100813211 DT.455851

24/752 AceView cDNA sequences (see all 752):

BQ006710 BF724751 CN482084 AI304521 BF725870 CR603972 AA295810 AW069352

BF725072 CF127834 AI804673 BQ277629 CB143006 BU542452 C05623 BP373370

CR622560 AI804694 BF725585 CA396705 CB138440 BC002648 BM669129 AA652190

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MYL9 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b
SP1:							-						-
SP2:							-		-				-
SP3:							-		-				-		-
SP4:							-		-				-		-		-
SP5:									-				-

ECgene alternative splicing isoforms for MYL9

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MYL9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAGTGTGCT

About this image

MYL9 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Gut Tube

Kidney

Kidney

Lower Urinary Tract

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

Definitive endoderm-like cells (Generation of mesend...)

Epiblast-like cells (Reconstitution of mo...)

Primordial germ cell-like cells (Reconstitution of mo...)

See MYL9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MYL9

SOURCE GeneReport for Unigene cluster: Hs.504687

UniProtKB/Swiss-Prot: MYL9_HUMAN, P24844

Tissue specificity: Smooth muscle tissues and in some, but not all, nonmuscle cells

SABiosciences Expression via Pathway-Focused PCR Array including MYL9:

Cell Motility in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYL9

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL9

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MYL9 gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MYL9¹	myosin, light chain 9, regulatory	88.18(n) 99.42(a)		396215 NM_205278.1 NP_990609.1
lizard (Anolis carolinensis)	Reptilia	MYL9⁶ --	--	99(a) 65(a)	1 ↔ 1 possible ortholog	4(138601701-138609376) GL343470.1(472422-472746)
African clawed frog (Xenopus laevis)	Amphibia	Xl.11918²	Xenopus laevis transcribed sequence with strong similarity more	85.79(n)		BJ067417.1
zebrafish (Danio rerio)	Actinopterygii	wufa10d12²	Danio rerio cDNA clone IMAGE5605247, partial cds	83.05(n)		BC052106.1
fruit fly (Drosophila melanogaster)	Insecta	sqh³	cytokinesis myosin ATPase	81(a)		1 5E1 --
worm (Caenorhabditis elegans)	Secernentea	mlc-2³	--	48(a) (best of 2)		X(17486697-17487363) --
rice (Oryza sativa)	Liliopsida	--	OsCML9 - Calmodulin-related calcium sensor protein...	28(a)	possible ortholog	5(24067532-24068539)

ENSEMBL Gene Tree for MYL9 (if available)
TreeFam Gene Tree for MYL9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MYL9 gene

MYL12A² MYL7² MYL10² MYL5² MYL2² MYLPF² MYL12B²

18/22 SIMAP similar genes for MYL9 using alignment to 2 protein entries: MYL9_HUMAN (see all proteins) (see all similar genes):

MYL12A MRLC3 MYL12B MYLPF MYL2 MYL5

MYL7 CALM2 CALM1 CALM3 CALML3 MYL10

TNNC2 CABP5 TNNC1 CABP2 CALML4 CALML6

MYL9 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for MYL9
PGOHUM00000258653 PGOHUM00000237441 PGOHUM00000249306

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6015414^1,2	H	--	31909525(+)	`CAATCC/ATAAGT`	1	--	int¹		4		NS EA	408
rs7270524^1,2	C,F,H,	--	31910128(+)	`TGCCAA/GTCATT`	1	--	int¹		10		NS EA NA WA	1204
rs12624517^1,2	H	--	31910371(+)	`gtggcA/Gggcgc`	1	--	int¹		0	--	--	--	--
rs7267743^1,2	C,	--	31910374(+)	`gcgggC/Tgcctg`	1	--	int¹		0	--	--	--	--
rs11906682^1,2	C,H,	--	31910418(+)	`aatggC/Tgtgaa`	1	--	int¹		0	--	--	--	--
rs115422879^1,2	C,F,	--	31910654(+)	`CAGCTG/AGCCAG`	1	--	int¹		1		WA	118
rs116988349^1,2	C,F,	--	31910662(+)	`CAGGCG/ACTGTG`	1	--	int¹		1		NA	120
rs61627664^1,2		--	31910668(+)	`CTGTGA/GCTCAC`	1	--	int¹		0	--	--	--	--
rs73905363^1,2	C,	--	31911024(+)	`GGGGCG/AGCCAG`	1	--	int¹		1		WA	2
rs7274366^1,2	C,F,A,H,	--	31911061(+)	`CCATCT/CCAGGC`	1	--	int¹		5		NS EA WA	536

HapMap Linkage Disequilibrium report for MYL9 (35169887 - 35178228 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MYL9: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MYL9 for disorders           About GeneDecksing

OMIM gene information: 609905    OMIM disorders: --

4 diseases for MYL9:    About MalaCards

myotonic dystrophy familial hypertrophic cardiomyopathy hypertrophic cardiomyopathy cardiomyopathy

1 disease from the University of Copenhagen DISEASES database for MYL9:

Familial hypertrophic cardiomyopathy

2 Novoseek disease relationships for MYL9 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
heart failure	18.9	1	12566123 (1)
tumors	0	1	17190792 (1)

Export disorders for MYL9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MYL9 gene, integrated from 9 sources (see all 55):
(articles sorted by number of sources associating them with MYL9)

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Characterization and differential expression of human vascular smooth muscle myosin light chain 2 isoform in nonmuscle cells. (PubMed id 2526655)^{1, 2, 3} Kumar C.C.... Leibowitz P.J. (1989)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells. (PubMed id 11942626)^{1, 2} Iwasaki T.... Hosoya H. (2001)
MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9. (PubMed id 19724058)^{1, 9} Gilles L....Raslova H. (2009)
The E22K mutation of myosin RLC that causes familial hypertrophic cardiomyopathy increases calcium sensitivity of force and ATPase in transgenic mice. (PubMed id 16076902)^{1, 9} Szczesna-Cordary D....Diaz-Perez Z. (2005)
Sp1 phosphorylation by cyclin-dependent kinase 1/cycli n B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)¹ Chuang J.Y....Hung J.J. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Nogo-B regulates migration and contraction of airway smooth muscle cells by decreasing ARPC 2/3 and increasing MYL-9 expression. (PubMed id 21251247)¹ Xu W....Li Q. (2011)
Caspase-activated ROCK-1 allows erythroblast terminal maturation independently of cytokine-induced Rho signaling. (PubMed id 21072057)² Gabet A.S.... Courtois G. (2011)
New modularity of DAP-kinases: alternative splicing o f the DRP-1 gene produces a ZIPk-like isoform. (PubMed id 21408167)² Shoval Y....Pietrokovski S. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10398	HGNC: 15754	AceView: MYL9	Ensembl:ENSG00000101335	euGenes: HUgn10398
ECgene: MYL9	Kegg: 10398	H-InvDB: MYL9

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MYL9	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MYL9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MYL9 gene:
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GeneCards and IP:
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myosin, light chain 9, regulatory

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MYL9 Gene

myosin, light chain 9, regulatory

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