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Aliases for MYL9 Gene

Aliases for MYL9 Gene

  • Myosin, Light Chain 9, Regulatory 2 3
  • MLC2 3 4 6
  • Myosin Regulatory Light Chain 2, Smooth Muscle Isoform 3 4
  • Myosin, Light Polypeptide 9, Regulatory 2 3
  • Myosin Regulatory Light Chain MRLC1 3 4
  • Myosin Regulatory Light Chain 1 2 3
  • Myosin Regulatory Light Chain 9 3 4
  • 20 KDa Myosin Light Chain 3 4
  • Myosin RLC 3 4
  • MLC-2C 3 4
  • MRLC1 3 4
  • MYRL2 3 4
  • LC20 3 4
  • Myosin Regulatory Light Polypeptide 9 3
  • Myosin Regulatory Light Chain 2 2
  • Smooth Muscle Isoform 2

External Ids for MYL9 Gene

Previous GeneCards Identifiers for MYL9 Gene

  • GC20P034898
  • GC20P035808
  • GC20P035855
  • GC20P034603
  • GC20P035169
  • GC20P031906

Summaries for MYL9 Gene

Entrez Gene Summary for MYL9 Gene

  • Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYL9 Gene

MYL9 (Myosin, Light Chain 9, Regulatory) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include calcium ion binding and structural constituent of muscle. An important paralog of this gene is MYL12A.

UniProtKB/Swiss-Prot for MYL9 Gene

  • Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion

Tocris Summary for MYL9 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name), almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II. Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by intracellular Ca2+ concentrations.

Gene Wiki entry for MYL9 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL9 Gene

Genomics for MYL9 Gene

Regulatory Elements for MYL9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MYL9 Gene

Start:
36,541,484 bp from pter
End:
36,551,447 bp from pter
Size:
9,964 bases
Orientation:
Plus strand

Genomic View for MYL9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL9 Gene

Proteins for MYL9 Gene

  • Protein details for MYL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24844-MYL9_HUMAN
    Recommended name:
    Myosin regulatory light polypeptide 9
    Protein Accession:
    P24844
    Secondary Accessions:
    • E1P5T6
    • Q9BQL9
    • Q9BUF9
    • Q9H136

    Protein attributes for MYL9 Gene

    Size:
    172 amino acids
    Molecular mass:
    19827 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains
    Miscellaneous:
    • This chain binds calcium

    Alternative splice isoforms for MYL9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYL9 Gene

Proteomics data for MYL9 Gene at MOPED

Post-translational modifications for MYL9 Gene

  • Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge (By similarity).
  • Ubiquitination at Lys51
  • Modification sites at PhosphoSitePlus

Other Protein References for MYL9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MYL9 (MRLC1)

No data available for DME Specific Peptides for MYL9 Gene

Domains for MYL9 Gene

Gene Families for MYL9 Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • MYL :Myosins / Light chain

Protein Domains for MYL9 Gene

Suggested Antigen Peptide Sequences for MYL9 Gene

Graphical View of Domain Structure for InterPro Entry

P24844

UniProtKB/Swiss-Prot:

MYL9_HUMAN :
  • P24844
Domain:
  • Contains 3 EF-hand domains.
genes like me logo Genes that share domains with MYL9: view

Function for MYL9 Gene

Molecular function for MYL9 Gene

UniProtKB/Swiss-Prot Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion

Gene Ontology (GO) - Molecular Function for MYL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0008307 structural constituent of muscle TAS 2526655
genes like me logo Genes that share ontologies with MYL9: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYL9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MYL9 Gene

Localization for MYL9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYL9 Gene COMPARTMENTS Subcellular localization image for MYL9 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MYL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IEA --
GO:0005829 cytosol TAS --
GO:0005859 muscle myosin complex TAS 2526655
GO:0016460 myosin II complex --
GO:0030018 Z disc IEA --
genes like me logo Genes that share ontologies with MYL9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYL9 Gene

Pathways for MYL9 Gene

genes like me logo Genes that share pathways with MYL9: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MYL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS --
GO:0006937 regulation of muscle contraction TAS 2526655
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007411 axon guidance TAS --
GO:0048013 ephrin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with MYL9: view

Compounds for MYL9 Gene

(4) Tocris Compounds for MYL9 Gene

Compound Action Cas Number
(�)-Blebbistatin Selective inhibitor of myosin II ATPase activity [674289-55-5]
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (�)-blebbistatin (Cat. No. 1760) [1177356-70-5]
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (�)-blebbistatin (Cat. No. 1760) [856925-71-8]
BTS Selective inhibitor of skeletal muscle myosin II ATPase activity [1576-37-0]

(1) HMDB Compounds for MYL9 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(4) Novoseek inferred chemical compound relationships for MYL9 Gene

Compound -log(P) Hits PubMed IDs
actomyosin 69.4 3
okadaic acid 37.9 1
isoproterenol 21.3 1
calcium 17.3 5
genes like me logo Genes that share compounds with MYL9: view

Transcripts for MYL9 Gene

mRNA/cDNA for MYL9 Gene

Unigene Clusters for MYL9 Gene

Myosin, light chain 9, regulatory:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYL9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYL9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: - -

Relevant External Links for MYL9 Gene

GeneLoc Exon Structure for
MYL9
ECgene alternative splicing isoforms for
MYL9

Expression for MYL9 Gene

mRNA expression in normal human tissues for MYL9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYL9 Gene

This gene is overexpressed in Esophagus - Muscularis (6.1), Artery - Tibial (5.4), Esophagus - Gastroesophageal Junction (5.3), and Colon - Sigmoid (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYL9 Gene

SOURCE GeneReport for Unigene cluster for MYL9 Gene Hs.504687

mRNA Expression by UniProt/SwissProt for MYL9 Gene

P24844-MYL9_HUMAN
Tissue specificity: Smooth muscle tissues and in some, but not all, nonmuscle cells
genes like me logo Genes that share expressions with MYL9: view

In Situ Assay Products

Orthologs for MYL9 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYL9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYL9 35
  • 99.81 (n)
  • 100 (a)
MYL9 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYL9 35
  • 93.02 (n)
  • 99.42 (a)
MYL9 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYL9 35
  • 93.02 (n)
  • 100 (a)
MYL9 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myl9 35
  • 92.05 (n)
  • 99.42 (a)
Myl9 16
Myl9 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYL9 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYL9 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myl9 35
  • 91.03 (n)
  • 98.24 (a)
chicken
(Gallus gallus)
Aves MYL9 35
  • 88.18 (n)
  • 99.42 (a)
MYL9 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYL9 36
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11918 35
tropical clawed frog
(Silurana tropicalis)
Amphibia myl9 35
  • 84.88 (n)
  • 96.51 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8988 35
zebrafish
(Danio rerio)
Actinopterygii myl9a 36
  • 92 (a)
OneToMany
myl9b 35
  • 83.33 (n)
  • 94.77 (a)
myl9b 36
  • 94 (a)
OneToMany
wufa10d12 35
fruit fly
(Drosophila melanogaster)
Insecta sqh 36
  • 80 (a)
OneToMany
sqh 37
  • 81 (a)
worm
(Caenorhabditis elegans)
Secernentea mlc-4 36
  • 71 (a)
OneToMany
mlc-2 37
  • 48 (a)
mlc-1 37
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5139 36
  • 80 (a)
OneToMany
Species with no ortholog for MYL9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYL9 Gene

ENSEMBL:
Gene Tree for MYL9 (if available)
TreeFam:
Gene Tree for MYL9 (if available)

Paralogs for MYL9 Gene

Paralogs for MYL9 Gene

Selected SIMAP similar genes for MYL9 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MYL9 Gene

genes like me logo Genes that share paralogs with MYL9: view

Variants for MYL9 Gene

Structural Variations from Database of Genomic Variants (DGV) for MYL9 Gene

Variant ID Type Subtype PubMed ID
nsv833967 CNV Loss 17160897

Relevant External Links for MYL9 Gene

HapMap Linkage Disequilibrium report
MYL9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MYL9 Gene

Disorders for MYL9 Gene

(1) University of Copenhagen DISEASES for MYL9 Gene

(2) Novoseek inferred disease relationships for MYL9 Gene

Disease -log(P) Hits PubMed IDs
heart failure 18.9 1
tumors 0 1
genes like me logo Genes that share disorders with MYL9: view

No data available for UniProtKB/Swiss-Prot for MYL9 Gene

Publications for MYL9 Gene

  1. Characterization and differential expression of human vascular smooth muscle myosin light chain 2 isoform in nonmuscle cells. (PMID: 2526655) Kumar C.C. … Leibowitz P.J. (Biochemistry 1989) 2 3 4
  2. MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9. (PMID: 19724058) Gilles L. … Raslova H. (Blood 2009) 3 23
  3. The E22K mutation of myosin RLC that causes familial hypertrophic cardiomyopathy increases calcium sensitivity of force and ATPase in transgenic mice. (PMID: 16076902) Szczesna-Cordary D. … Diaz-Perez Z. (J. Cell. Sci. 2005) 3 23
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells. (PMID: 11942626) Iwasaki T. … Hosoya H. (Cell Struct. Funct. 2001) 3 4

Products for MYL9 Gene

  • Addgene plasmids for MYL9

Sources for MYL9 Gene

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