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Aliases for MYL9 Gene

Aliases for MYL9 Gene

  • Myosin Light Chain 9 2 3 5
  • Myosin Regulatory Light Chain 2, Smooth Muscle Isoform 2 3 4
  • Myosin, Light Polypeptide 9, Regulatory 2 3
  • Myosin Regulatory Light Chain MRLC1 3 4
  • Myosin, Light Chain 9, Regulatory 2 3
  • Myosin Regulatory Light Chain 1 2 3
  • Myosin Regulatory Light Chain 9 3 4
  • 20 KDa Myosin Light Chain 3 4
  • Myosin RLC 3 4
  • MLC-2C 3 4
  • MRLC1 3 4
  • MYRL2 3 4
  • MLC2 3 4
  • LC20 3 4
  • Myosin Regulatory Light Polypeptide 9 3

External Ids for MYL9 Gene

Previous GeneCards Identifiers for MYL9 Gene

  • GC20P034898
  • GC20P035808
  • GC20P035855
  • GC20P034603
  • GC20P035169
  • GC20P031906

Summaries for MYL9 Gene

Entrez Gene Summary for MYL9 Gene

  • Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYL9 Gene

MYL9 (Myosin Light Chain 9) is a Protein Coding gene. Diseases associated with MYL9 include Amyloidosis, Primary Localized Cutaneous, 1 and Cardiomyopathy, Familial Hypertrophic. Among its related pathways are Activation of cAMP-Dependent PKA and Semaphorin interactions. GO annotations related to this gene include calcium ion binding and structural constituent of muscle. An important paralog of this gene is MYL12B.

UniProtKB/Swiss-Prot for MYL9 Gene

  • Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.

Tocris Summary for MYL9 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.

Gene Wiki entry for MYL9 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL9 Gene

Genomics for MYL9 Gene

Regulatory Elements for MYL9 Gene

Enhancers for MYL9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F036459 0.6 ENCODE 22 -74.7 -74721 13.6 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 RBM12 AAR2 CPNE1 TGIF2 RBL1 RPL36P4 MYL9 TLDC2 DLGAP4-AS1 MANBAL
GH20F037539 0.5 ENCODE 20 +999.9 999904 2.9 MLX DMAP1 ZNF48 SLC30A9 ELK1 GATA2 MIER2 ZNF592 CREB3 MEF2D MYL9 SAMHD1 GHRH MROH8 RPN2 BLCAP PPIAP3 LINC01746
GH20F036082 0.7 Ensembl ENCODE 20 -456.4 -456415 5.0 PKNOX1 ATF1 ZNF133 SIN3A ELK1 FOS KLF13 DEK NFYC JUNB EPB41L1 MYL9 AAR2 SAMHD1 CPNE1 CNBD2 ENSG00000237063 HMGB3P2
GH20F036540 0.5 FANTOM5 ENCODE 14.4 +1.5 1483 5.3 HDGF SIN3A YY1 ZNF121 GLIS2 GATA2 ELK1 ZNF263 SP3 GLIS1 RBM12 CPNE1 MYL9 RPL36P4 TLDC2 AAR2 TGIF2 RBL1 DLGAP4 GC20P036550
GH20F036516 0.4 ENCODE 12.8 -25.3 -25322 0.1 MYL9 GC20P036530 GC20P036472
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MYL9 on UCSC Golden Path with GeneCards custom track

Promoters for MYL9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001837098 216 2201 SRF CTCF NRF1 RAD21 ZBTB7A ZNF121 ZFHX2 POLR2A IKZF1 MXD3
ENSR00000009260 1816 201 NFXL1 GLIS2 ZNF366 SCRT2 ZNF263 SP3 NR2F2 IKZF1 ZNF341 HNF4A

Genomic Location for MYL9 Gene

Chromosome:
20
Start:
36,541,484 bp from pter
End:
36,551,447 bp from pter
Size:
9,964 bases
Orientation:
Plus strand

Genomic View for MYL9 Gene

Genes around MYL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL9 Gene

Proteins for MYL9 Gene

  • Protein details for MYL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24844-MYL9_HUMAN
    Recommended name:
    Myosin regulatory light polypeptide 9
    Protein Accession:
    P24844
    Secondary Accessions:
    • E1P5T6
    • Q9BQL9
    • Q9BUF9
    • Q9H136

    Protein attributes for MYL9 Gene

    Size:
    172 amino acids
    Molecular mass:
    19827 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains.
    Miscellaneous:
    • This chain binds calcium.

    Alternative splice isoforms for MYL9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYL9 Gene

Post-translational modifications for MYL9 Gene

  • Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYL9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MYL9 (MRLC1)
  • Abcam antibodies for MYL9

No data available for DME Specific Peptides for MYL9 Gene

Domains & Families for MYL9 Gene

Protein Domains for MYL9 Gene

Suggested Antigen Peptide Sequences for MYL9 Gene

Graphical View of Domain Structure for InterPro Entry

P24844

UniProtKB/Swiss-Prot:

MYL9_HUMAN :
  • Contains 3 EF-hand domains.
Domain:
  • Contains 3 EF-hand domains.
genes like me logo Genes that share domains with MYL9: view

Function for MYL9 Gene

Molecular function for MYL9 Gene

UniProtKB/Swiss-Prot Function:
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.

Gene Ontology (GO) - Molecular Function for MYL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0008307 structural constituent of muscle TAS 2526655
GO:0032036 myosin heavy chain binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MYL9: view
genes like me logo Genes that share phenotypes with MYL9: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MYL9

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYL9 Gene

Localization for MYL9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYL9 Gene COMPARTMENTS Subcellular localization image for MYL9 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
mitochondrion 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MYL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IEA --
GO:0005829 cytosol TAS --
GO:0005859 muscle myosin complex TAS 2526655
GO:0016459 myosin complex IEA --
GO:0016460 myosin II complex IEA --
genes like me logo Genes that share ontologies with MYL9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYL9 Gene

Pathways & Interactions for MYL9 Gene

genes like me logo Genes that share pathways with MYL9: view

SIGNOR curated interactions for MYL9 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MYL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS --
GO:0006937 regulation of muscle contraction TAS 2526655
GO:0070527 platelet aggregation IMP 23382103
genes like me logo Genes that share ontologies with MYL9: view

Drugs & Compounds for MYL9 Gene

(5) Drugs for MYL9 Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
(R)-(+)-Blebbistatin Pharma non-muscle myosin II ATPases inhibitor, cell-permeable, Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 0
BTS Pharma Selective inhibitor of skeletal muscle myosin II ATPase activity 0

(3) Additional Compounds for MYL9 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-Blebbistatin
674289-55-5
(S)-(-)-Blebbistatin
856925-71-8

(4) Tocris Compounds for MYL9 Gene

Compound Action Cas Number
(+-)-Blebbistatin Selective inhibitor of myosin II ATPase activity 674289-55-5
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 1177356-70-5
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760) 856925-71-8
BTS Selective inhibitor of skeletal muscle myosin II ATPase activity 1576-37-0
genes like me logo Genes that share compounds with MYL9: view

Transcripts for MYL9 Gene

mRNA/cDNA for MYL9 Gene

Unigene Clusters for MYL9 Gene

Myosin, light chain 9, regulatory:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MYL9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYL9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: - -

Relevant External Links for MYL9 Gene

GeneLoc Exon Structure for
MYL9
ECgene alternative splicing isoforms for
MYL9

Expression for MYL9 Gene

mRNA expression in normal human tissues for MYL9 Gene

mRNA differential expression in normal tissues according to GTEx for MYL9 Gene

This gene is overexpressed in Esophagus - Muscularis (x6.1), Artery - Tibial (x5.4), Esophagus - Gastroesophageal Junction (x5.3), and Colon - Sigmoid (x5.3).

Protein differential expression in normal tissues from HIPED for MYL9 Gene

This gene is overexpressed in Colon muscle (24.1) and Colon (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYL9 Gene



Protein tissue co-expression partners for MYL9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MYL9 Gene:

MYL9

SOURCE GeneReport for Unigene cluster for MYL9 Gene:

Hs.504687

mRNA Expression by UniProt/SwissProt for MYL9 Gene:

P24844-MYL9_HUMAN
Tissue specificity: Smooth muscle tissues and in some, but not all, nonmuscle cells.
genes like me logo Genes that share expression patterns with MYL9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MYL9 Gene

Orthologs for MYL9 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYL9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYL9 34 35
  • 99.81 (n)
cow
(Bos Taurus)
Mammalia MYL9 34 35
  • 93.02 (n)
dog
(Canis familiaris)
Mammalia MYL9 34 35
  • 93.02 (n)
mouse
(Mus musculus)
Mammalia Myl9 34 16 35
  • 92.05 (n)
oppossum
(Monodelphis domestica)
Mammalia MYL9 35
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myl9 34
  • 91.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MYL9 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYL9 34 35
  • 88.18 (n)
lizard
(Anolis carolinensis)
Reptilia MYL9 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myl9 34
  • 84.88 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11918 34
zebrafish
(Danio rerio)
Actinopterygii myl9a 35
  • 92 (a)
OneToMany
myl9b 34 35
  • 83.33 (n)
wufa10d12 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8988 34
fruit fly
(Drosophila melanogaster)
Insecta sqh 36 35
  • 81 (a)
worm
(Caenorhabditis elegans)
Secernentea mlc-4 35
  • 71 (a)
OneToMany
mlc-1 36
  • 48 (a)
mlc-2 36
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5139 35
  • 80 (a)
OneToMany
Species where no ortholog for MYL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYL9 Gene

ENSEMBL:
Gene Tree for MYL9 (if available)
TreeFam:
Gene Tree for MYL9 (if available)

Paralogs for MYL9 Gene

Paralogs for MYL9 Gene

(21) SIMAP similar genes for MYL9 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MYL9 Gene

genes like me logo Genes that share paralogs with MYL9: view

Variants for MYL9 Gene

Sequence variations from dbSNP and Humsavar for MYL9 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1045348 -- 36,549,674(+) CCCCT(C/T)TCAGT intron-variant, utr-variant-3-prime
rs1045566 -- 36,549,699(+) CCTGA(A/C)CGGCC intron-variant, utr-variant-3-prime
rs111320207 -- 36,546,992(+) CCTGG(C/T)GTCAC intron-variant
rs111721872 -- 36,547,960(+) GGGGA(C/T)GGGGG intron-variant
rs111789587 -- 36,540,726(+) ACCCT(A/C)CGACA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MYL9 Gene

Variant ID Type Subtype PubMed ID
esv3645738 CNV loss 21293372
nsv1057192 CNV loss 25217958
nsv833967 CNV loss 17160897

Variation tolerance for MYL9 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYL9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYL9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYL9 Gene

Disorders for MYL9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MYL9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amyloidosis, primary localized cutaneous, 1
  • primary cutaneous amyloidosis
cardiomyopathy, familial hypertrophic
  • cardiomyopathy, hypertrophic, 1
- elite association - COSMIC cancer census association via MalaCards
Search MYL9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYL9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYL9
genes like me logo Genes that share disorders with MYL9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYL9 Gene

Publications for MYL9 Gene

  1. Characterization and differential expression of human vascular smooth muscle myosin light chain 2 isoform in nonmuscle cells. (PMID: 2526655) Kumar C.C. … Leibowitz P.J. (Biochemistry 1989) 2 3 4 64
  2. MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9. (PMID: 19724058) Gilles L. … Raslova H. (Blood 2009) 3 22 64
  3. The E22K mutation of myosin RLC that causes familial hypertrophic cardiomyopathy increases calcium sensitivity of force and ATPase in transgenic mice. (PMID: 16076902) Szczesna-Cordary D. … Diaz-Perez Z. (J. Cell. Sci. 2005) 3 22 64
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  5. Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells. (PMID: 11942626) Iwasaki T. … Hosoya H. (Cell Struct. Funct. 2001) 3 4 64

Products for MYL9 Gene

Sources for MYL9 Gene

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