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Aliases for MYL7 Gene

Aliases for MYL7 Gene

  • Myosin, Light Chain 7, Regulatory 2 3
  • MYLC2A 3 4 6
  • MYL2A 3 4 6
  • MLC2a 3 4 6
  • Myosin, Light Polypeptide 7, Regulatory 2 3
  • Myosin Regulatory Light Chain 7 3 4
  • Myosin Light Chain 2a 3 4
  • MLC-2a 3 4
  • Myosin Regulatory Light Chain 2, Atrial Isoform 3

External Ids for MYL7 Gene

Summaries for MYL7 Gene

GeneCards Summary for MYL7 Gene

MYL7 (Myosin, Light Chain 7, Regulatory) is a Protein Coding gene. Diseases associated with MYL7 include fechtner syndrome. Among its related pathways are RhoGDI Pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include calcium ion binding and ATPase activity, coupled. An important paralog of this gene is MYL12A.

Tocris Summary for MYL7 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name), almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II. Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by intracellular Ca2+ concentrations.

Gene Wiki entry for MYL7 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL7 Gene

Genomics for MYL7 Gene

Genomic Location for MYL7 Gene

Start:
44,138,864 bp from pter
End:
44,141,332 bp from pter
Size:
2,469 bases
Orientation:
Minus strand

Genomic View for MYL7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL7 Gene

Regulatory Elements for MYL7 Gene

Proteins for MYL7 Gene

  • Protein details for MYL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01449-MLRA_HUMAN
    Recommended name:
    Myosin regulatory light chain 2, atrial isoform
    Protein Accession:
    Q01449
    Secondary Accessions:
    • B2R4L3

    Protein attributes for MYL7 Gene

    Size:
    175 amino acids
    Molecular mass:
    19448 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains
    Miscellaneous:
    • This chain binds calcium

neXtProt entry for MYL7 Gene

Proteomics data for MYL7 Gene at MOPED

Post-translational modifications for MYL7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYL7 Gene

Domains for MYL7 Gene

Gene Families for MYL7 Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • MYL :Myosins / Light chain

Protein Domains for MYL7 Gene

UniProtKB/Swiss-Prot:

MLRA_HUMAN
Domain:
  • Contains 3 EF-hand domains.:
    • Q01449
genes like me logo Genes that share domains with MYL7: view

Function for MYL7 Gene

Gene Ontology (GO) - Molecular Function for MYL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MYL7: view
genes like me logo Genes that share phenotypes with MYL7: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MYL7 Gene

Localization for MYL7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYL7 Gene COMPARTMENTS Subcellular localization image for MYL7 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
mitochondrion 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MYL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016459 myosin complex NAS 1429676
GO:0031672 A band IDA 15621049
GO:0043197 dendritic spine IEA --
genes like me logo Genes that share ontologies with MYL7: view

Pathways for MYL7 Gene

genes like me logo Genes that share pathways with MYL7: view

Gene Ontology (GO) - Biological Process for MYL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS --
genes like me logo Genes that share ontologies with MYL7: view

Compounds for MYL7 Gene

(4) Tocris Compounds for MYL7 Gene

Compound Action Cas Number
(+-)-Blebbistatin Selective inhibitor of myosin II ATPase activity [674289-55-5]
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) [1177356-70-5]
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760) [856925-71-8]
BTS Selective inhibitor of skeletal muscle myosin II ATPase activity [1576-37-0]

(1) HMDB Compounds for MYL7 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with MYL7: view

Transcripts for MYL7 Gene

Unigene Clusters for MYL7 Gene

Myosin, light chain 7, regulatory:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYL7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: - - - -
SP7: -
SP8: -

Relevant External Links for MYL7 Gene

GeneLoc Exon Structure for
MYL7
ECgene alternative splicing isoforms for
MYL7

Expression for MYL7 Gene

mRNA expression in normal human tissues for MYL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYL7 Gene

This gene is overexpressed in Heart - Atrial Appendage (47.1) and Heart - Left Ventricle (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYL7 Gene

SOURCE GeneReport for Unigene cluster for MYL7 Gene Hs.75636

mRNA Expression by UniProt/SwissProt for MYL7 Gene

Q01449-MLRA_HUMAN
Tissue specificity: Predominantly expressed in adult atrial muscle.
genes like me logo Genes that share expressions with MYL7: view

Orthologs for MYL7 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYL7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYL7 36
  • 99.43 (n)
  • 100 (a)
MYL7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYL7 36
  • 91.05 (n)
  • 97.14 (a)
MYL7 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYL7 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myl7 36
  • 88.95 (n)
  • 95.43 (a)
Myl7 16
Myl7 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYL7 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYL7 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myl7 36
  • 89.64 (n)
  • 94.59 (a)
African clawed frog
(Xenopus laevis)
Amphibia mylc2a-prov 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9036 36
zebrafish
(Danio rerio)
Actinopterygii myl7 36
  • 72.94 (n)
  • 78.82 (a)
myl7 37
  • 77 (a)
OneToOne
mylc2a 36
fruit fly
(Drosophila melanogaster)
Insecta CG33098 37
  • 21 (a)
OneToMany
Mlc2 37
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mlc-1 37
  • 42 (a)
OneToMany
mlc-2 37
  • 42 (a)
OneToMany
Species with no ortholog for MYL7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MYL7 Gene

ENSEMBL:
Gene Tree for MYL7 (if available)
TreeFam:
Gene Tree for MYL7 (if available)

Paralogs for MYL7 Gene

Paralogs for MYL7 Gene

genes like me logo Genes that share paralogs with MYL7: view

Variants for MYL7 Gene

Sequence variations from dbSNP and Humsavar for MYL7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs737525 -- 44,139,630(-) CGTAC(C/T)CACCT intron-variant
rs741033 -- 44,140,166(-) TCCTG(C/G)CCATG intron-variant
rs882019 -- 44,139,230(-) TTGCC(C/T)CTTGG intron-variant
rs882020 -- 44,139,144(-) GGGTT(A/G)AAAAG intron-variant
rs1008384 -- 44,139,027(-) TCCCC(C/T)GCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYL7 Gene

Variant ID Type Subtype PubMed ID
nsv428165 CNV Gain 18775914
nsv8082 CNV Gain 18304495
nsv887996 CNV Loss 21882294
nsv470210 CNV Loss 18288195
nsv830983 CNV Loss 17160897

Relevant External Links for MYL7 Gene

HapMap Linkage Disequilibrium report
MYL7

Disorders for MYL7 Gene

(1) MalaCards Diseases for MYL7 Gene

Search for MYL7 Gene in MalaCards »

(1) University of Copenhagen DISEASES for MYL7 Gene

genes like me logo Genes that share disorders with MYL7: view

No data available for UniProtKB/Swiss-Prot for MYL7 Gene

Publications for MYL7 Gene

  1. Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis. (PMID: 8207020) Kubalak S.W. … Chien K.R. (J. Biol. Chem. 1994) 2 3 23
  2. Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development. (PMID: 1429676) Hailstones D.L. … Gunning P.W. (J. Biol. Chem. 1992) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium. (PMID: 15621049) Grimm M. … Eschenhagen T. (Cardiovasc. Res. 2005) 3
  5. Mutation in myosin heavy chain 6 causes atrial septal defect. (PMID: 15735645) Ching Y.-H. … Brook J.D. (Nat. Genet. 2005) 3

Products for MYL7 Gene

Sources for MYL7 Gene

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