Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MYL7 Gene

Aliases for MYL7 Gene

  • Myosin Light Chain 7 2 3 5
  • Myosin, Light Polypeptide 7, Regulatory 2 3
  • Myosin, Light Chain 7, Regulatory 2 3
  • Myosin Regulatory Light Chain 7 3 4
  • Myosin Light Chain 2a 3 4
  • MLC-2A 3 4
  • MYLC2A 3 4
  • MLC2A 3 4
  • MYL2A 3 4

External Ids for MYL7 Gene

Previous GeneCards Identifiers for MYL7 Gene

  • GC00U912966
  • GC07M043919
  • GC07M043951
  • GC07M044144
  • GC07M044178
  • GC07M044063

Summaries for MYL7 Gene

GeneCards Summary for MYL7 Gene

MYL7 (Myosin Light Chain 7) is a Protein Coding gene. Diseases associated with MYL7 include Fechtner Syndrome and Familial Atrial Fibrillation. Among its related pathways are ERK Signaling and Activation of cAMP-Dependent PKA. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is MYLPF.

Tocris Summary for MYL7 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.

Gene Wiki entry for MYL7 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL7 Gene

Genomics for MYL7 Gene

Regulatory Elements for MYL7 Gene

Enhancers for MYL7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MYL7 on UCSC Golden Path with GeneCards custom track

Genomic Location for MYL7 Gene

44,138,864 bp from pter
44,141,388 bp from pter
2,525 bases
Minus strand

Genomic View for MYL7 Gene

Genes around MYL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL7 Gene

Proteins for MYL7 Gene

  • Protein details for MYL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myosin regulatory light chain 2, atrial isoform
    Protein Accession:
    Secondary Accessions:
    • B2R4L3

    Protein attributes for MYL7 Gene

    175 amino acids
    Molecular mass:
    19448 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains.
    • This chain binds calcium.

neXtProt entry for MYL7 Gene

Proteomics data for MYL7 Gene at MOPED

Post-translational modifications for MYL7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYL7 Gene

Domains & Families for MYL7 Gene

Protein Domains for MYL7 Gene

Suggested Antigen Peptide Sequences for MYL7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 EF-hand domains.
  • Contains 3 EF-hand domains.
genes like me logo Genes that share domains with MYL7: view

Function for MYL7 Gene

genes like me logo Genes that share phenotypes with MYL7: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYL7 Gene

Localization for MYL7 Gene

Subcellular locations from

Jensen Localization Image for MYL7 Gene COMPARTMENTS Subcellular localization image for MYL7 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
mitochondrion 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MYL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016459 myosin complex NAS 1429676
genes like me logo Genes that share ontologies with MYL7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYL7 Gene

Pathways & Interactions for MYL7 Gene

genes like me logo Genes that share pathways with MYL7: view

Gene Ontology (GO) - Biological Process for MYL7 Gene


No data available for SIGNOR curated interactions for MYL7 Gene

Drugs & Compounds for MYL7 Gene

(1) Drugs for MYL7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(5) Additional Compounds for MYL7 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ML 9 hydrochloride
W-7 hydrochloride

(5) Tocris Compounds for MYL7 Gene

Compound Action Cas Number
(+-)-Blebbistatin Selective inhibitor of myosin II ATPase activity 674289-55-5
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 1177356-70-5
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760) 856925-71-8
ML 9 hydrochloride Myosin light chain kinase inhibitor 105637-50-1
W-7 hydrochloride Calmodulin antagonist. Inhibits myosin light chain kinase 61714-27-0
genes like me logo Genes that share compounds with MYL7: view

Transcripts for MYL7 Gene

Unigene Clusters for MYL7 Gene

Myosin, light chain 7, regulatory:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYL7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: - - - -
SP7: -
SP8: -

Relevant External Links for MYL7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYL7 Gene

mRNA expression in normal human tissues for MYL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYL7 Gene

This gene is overexpressed in Heart - Atrial Appendage (x47.1) and Heart - Left Ventricle (x5.5).

Protein differential expression in normal tissues from HIPED for MYL7 Gene

This gene is overexpressed in Fetal heart (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYL7 Gene

SOURCE GeneReport for Unigene cluster for MYL7 Gene Hs.75636

mRNA Expression by UniProt/SwissProt for MYL7 Gene

Tissue specificity: Predominantly expressed in adult atrial muscle.
genes like me logo Genes that share expression patterns with MYL7: view

Protein tissue co-expression partners for MYL7 Gene

- Elite partner

Primer Products

Orthologs for MYL7 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYL7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MYL7 35
  • 91.05 (n)
  • 97.14 (a)
MYL7 36
  • 97 (a)
(Mus musculus)
Mammalia Myl7 35
  • 88.95 (n)
  • 95.43 (a)
Myl7 16
Myl7 36
  • 95 (a)
(Pan troglodytes)
Mammalia MYL7 35
  • 99.43 (n)
  • 100 (a)
MYL7 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Myl7 35
  • 89.64 (n)
  • 94.59 (a)
(Canis familiaris)
Mammalia MYL7 36
  • 98 (a)
(Monodelphis domestica)
Mammalia MYL7 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia MYL7 36
  • 88 (a)
African clawed frog
(Xenopus laevis)
Amphibia mylc2a-prov 35
(Danio rerio)
Actinopterygii myl7 35
  • 72.94 (n)
  • 78.82 (a)
mylc2a 35
myl7 36
  • 77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9036 35
fruit fly
(Drosophila melanogaster)
Insecta CG33098 36
  • 21 (a)
Mlc2 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea mlc-1 36
  • 42 (a)
mlc-2 36
  • 42 (a)
Species with no ortholog for MYL7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MYL7 Gene

Gene Tree for MYL7 (if available)
Gene Tree for MYL7 (if available)

Paralogs for MYL7 Gene

Paralogs for MYL7 Gene

genes like me logo Genes that share paralogs with MYL7: view

Variants for MYL7 Gene

Sequence variations from dbSNP and Humsavar for MYL7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs882019 -- 44,139,230(-) TTGCC(C/T)CTTGG intron-variant
rs882020 -- 44,139,144(-) GGGTT(A/G)AAAAG intron-variant
rs1008384 -- 44,139,027(-) TCCCC(C/G/T)GCAGG intron-variant
rs6953355 -- 44,139,624(+) CAGGG(A/T)AGGTG intron-variant, reference, missense
rs12669054 -- 44,139,949(+) CCTCC(C/T)ACATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYL7 Gene

Variant ID Type Subtype PubMed ID
nsv428165 CNV Gain 18775914
nsv8082 CNV Gain 18304495
nsv887996 CNV Loss 21882294
nsv470210 CNV Loss 18288195
nsv830983 CNV Loss 17160897

Variation tolerance for MYL7 Gene

Residual Variation Intolerance Score: 54.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MYL7 Gene

Disorders for MYL7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MYL7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
fechtner syndrome
  • alport syndrome with leukocyte inclusions and macrothrombocytopenia
familial atrial fibrillation
  • atrial fibrillation, familial, 1
- elite association - COSMIC cancer census association via MalaCards
Search MYL7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYL7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MYL7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYL7 Gene

Publications for MYL7 Gene

  1. Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis. (PMID: 8207020) Kubalak S.W. … Chien K.R. (J. Biol. Chem. 1994) 2 3 23 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain endothelial cells. (PMID: 19794400) Zhong Y. … Toborek M. (J. Cereb. Blood Flow Metab. 2010) 3
  4. The microwell control of embryoid body size in order to regulate cardiac differentiation of human embryonic stem cells. (PMID: 19945747) Mohr J.C. … Kamp T.J. (Biomaterials 2010) 23
  5. Migration and differentiation of human umbilical cord stem cells after heart injury in chicken embryos. (PMID: 18393637) Torre-PAcrez N. … HurlAc J.M. (Stem Cells Dev. 2009) 23

Products for MYL7 Gene

Sources for MYL7 Gene