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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYL7 Gene

protein-coding   GIFtS: 60
GCID: GC07M044178

Myosin, Light Chain 7, Regulatory

(Previous names: myosin, light polypeptide 7, regulatory)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Myosin, Light Chain 7, Regulatory1 2     MLC2a2 3
Myosin, Light Polypeptide 7, Regulatory1 2     MYL2A2 3
Myosin Light Chain 2a2 3     MYLC2A2 3
Myosin Regulatory Light Chain 72 3     Myosin Regulatory Light Chain 2, Atrial Isoform2
MLC-2a2 3     

External Ids:    HGNC: 217191   Entrez Gene: 584982   Ensembl: ENSG000001066317   OMIM: 6139935   UniProtKB: Q014493   

Export aliases for MYL7 gene to outside databases

Previous GC identifers: GC00U912966 GC07M043919 GC07M043951 GC07M044144 GC07M044063


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MYL7 Gene: 
MYL7 (myosin, light chain 7, regulatory) is a protein-coding gene. Diseases associated with MYL7 include endometritis, and hypertrophic cardiomyopathy, and among its related super-pathways are Immune response CCR3 signaling in eosinophils and Activation of cAMP-Dependent PKA. GO annotations related to this gene include ATPase activity, coupled and calcium ion binding. An important paralog of this gene is MYL12A.

summary for MYL7 Gene:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYL7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYL7 gene promoter:
         COUP-TF1   COUP-TF   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYL7 promoter sequence
   Search SABiosciences Chromatin IP Primers for MYL7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYL7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21-p11.2   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p21-p11.2

MYL7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL7 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M044178:  view genomic region     (about GC identifiers)

Start:
44,178,463 bp from pter      End:
44,180,931 bp from pter
Size:
2,469 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 44,217,962-44,220,416     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MLRA_HUMAN, Q01449 (See protein sequence)
Recommended Name: Myosin regulatory light chain 2, atrial isoform  
Size: 175 amino acids; 19448 Da
Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains
Miscellaneous: This chain binds calcium
Secondary accessions: B2R4L3

Explore the universe of human proteins at neXtProt for MYL7: NX_Q01449

Explore proteomics data for MYL7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q01449

  • MYL7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MYL7 Protein Expression
    REFSEQ proteins: NP_067046.1  
    ENSEMBL proteins: 
     ENSP00000416010   ENSP00000223364   ENSP00000403360   ENSP00000389202   ENSP00000403988  
     ENSP00000399398   ENSP00000411340   ENSP00000404918  

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    Novus Biologicals MYL7 Protein
    Novus Biologicals MYL7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MYL7
    Cloud-Clone Corp. Proteins for MYL7 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016459myosin complex NAS1429676
    GO:0031672A band IDA15621049
    GO:0043197dendritic spine IEA--

    MYL7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing
    MYL: Myosins / Light chain

    3 InterPro protein domains:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q01449

    ProtoNet protein and cluster: Q01449

    UniProtKB/Swiss-Prot: MLRA_HUMAN, Q01449
    Similarity: Contains 3 EF-hand domains


    MYL7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000146microfilament motor activity NAS--
    GO:0005509calcium ion binding NAS--
    GO:0005515protein binding ----
    GO:0042623ATPase activity, coupled NAS--
         
    MYL7 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Myl7):
     cardiovascular system  cellular  embryogenesis  growth/size  homeostasis/metabolism 
     mortality/aging  muscle 

    MYL7 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MYL7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MYL7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYL7 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MYL7 About   (see all 16)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response CCR3 signaling in eosinophils
    Immune response CCR3 signaling in eosinophils0.51
    Inhibitory action of Lipoxins on neutrophil migration0.51
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    3PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    4Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin-mediated cell adhesion and migration0.49
    Cell adhesion Tight junctions0.33
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    5Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for MYL7
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils
    Development MAG-dependent inhibition of neurite outgrowth

    5/16 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYL7 (see all 16)
        Activation of PKA through GPCR
    RhoA Pathway
    PKA Signaling
    Guidance Cues and Growth Cone Motility
    Antioxidant Action of Vitamin-C

    5/6 GeneGo (Thomson Reuters) Pathways for MYL7 (see all 6)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Tight junctions


    4         Kegg Pathways  (Kegg details for MYL7):
        Focal adhesion
    Tight junction
    Leukocyte transendothelial migration
    Regulation of actin cytoskeleton


    MYL7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYL7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/17 Interacting proteins for MYL7 (Q014493 ENSP000002233644) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYH6P135333I2D: score=1 
    ACTBENSP000003499604STRING: ENSP00000349960
    ACTG1ENSP000003315144STRING: ENSP00000331514
    CGNENSP000002716364STRING: ENSP00000271636
    MYH10ENSP000002692434STRING: ENSP00000269243
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006939smooth muscle contraction NAS--
    GO:0030048actin filament-based movement NAS--

    MYL7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MYL7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BTSSelective inhibitor of skeletal muscle myosin II ATPase activity[1576-37-0]
    (R)-(+)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)[1177356-70-5]
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)[856925-71-8]
    (+-)-BlebbistatinSelective inhibitor of myosin II ATPase activity[674289-55-5]

    1 HMDB Compound for MYL7    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about MYL7 / MLRA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYL7 gene: 
    NM_021223.2  

    Unigene Cluster for MYL7:

    Myosin, light chain 7, regulatory
    Hs.75636  [show with all ESTs]
    Unigene Representative Sequence: BI836837
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000446581 ENST00000223364(uc003tkg.3) ENST00000458240 ENST00000434895
    ENST00000457314 ENST00000447951 ENST00000476118 ENST00000431289 ENST00000431007
    ENST00000457910
    miRNA
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    Additional mRNA sequence: 

    AK311869.1 BC027915.1 M94547.1 

    20 DOTS entries:

    DT.450936  DT.91660291  DT.95084864  DT.87078096  DT.100754736  DT.100754737  DT.121061744  DT.91660254 
    DT.95371985  DT.95372000  DT.121061729  DT.95371983  DT.40292489  DT.102826012  DT.121061722  DT.121061728 
    DT.91660294  DT.95371995  DT.95371996  DT.121061740 

    24/335 AceView cDNA sequences (see all 335):

    AJ710773 AI332570 AJ711909 AA248691 BX501516 AA346344 AA247791 AA249277 
    C05145 NM_021223 BQ445851 N86069 T28710 AA248626 AJ708771 AJ709502 
    AI333507 BC027915 AA347095 N86275 AJ706807 AA247462 AJ712021 AI355734 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MYL7 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7
    SP1:                                      -     -                       -           -         
    SP2:                          -           -     -                       -           -         
    SP3:                                      -     -                       -     -     -         
    SP4:                                      -     -                                   -         
    SP5:                          -           -                                                   


    ECgene alternative splicing isoforms for MYL7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYL7 expression in normal human tissues (normalized intensities)      MYL7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGACGAGAA
    MYL7 Expression
    About this image


    MYL7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 21 entries
             Cardiomyocytes Right Atrium
             Left Atrium
             Cardiac progenitor cells (Sca1+)
             Cardiomyocyte-like progenitor cells ( Derivation of cardiomyocytes from pluripotent...
             left ventricular apex samples   
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
             Endothelial progenitor cells ( Derivation and purification of endothelial precursor...
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             hIPS1
     
     Blood Brain Barrier (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles

    See MYL7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYL7

    SOURCE GeneReport for Unigene cluster: Hs.75636

    UniProtKB/Swiss-Prot: MLRA_HUMAN, Q01449
    Tissue specificity: Predominantly expressed in adult atrial muscle

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MYL7 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myl71 , 5 myosin, light polypeptide 7, regulatory1, 5 88.95(n)1
    95.43(a)1
      11 (3.88 cM)5
    178981  NM_022879.21  NP_075017.21 
     58966375 
    African clawed frog
    (Xenopus laevis)
    Amphibia mylc2a-prov2 myosin light chain, regulatory A 79.41(n)    Z33999.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mylc2a2 myosin light chain, regulatory A 75.19(n)   30592  AY057074.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mlc26
    CG330986
    --
    31(a)
    21(a)
    many ↔ many
    many ↔ many
    3R(25997160-26000273)
    3R(8212910-8214517)
    worm
    (Caenorhabditis elegans)
    Secernentea mlc-26
    mlc-16
    Myosin regulatory light chain 1
    42(a)
    42(a)
    many ↔ many
    many ↔ many
    X(17455779-17456594)
    X(17459160-17460767)


    ENSEMBL Gene Tree for MYL7 (if available)
    TreeFam Gene Tree for MYL7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYL7 gene
    MYL12A2  MYL102  MYL92  MYL52  MYL22  MYLPF2  MYL12B2  
    13 SIMAP similar genes for MYL7 using alignment to 8 protein entries:     MLRA_HUMAN (see all proteins):
    MYL5    MYLPF    MYL12A    MYL2    MYL9    MRLC3
    MYL12B    MYL10    CALM2    CALM1    CALM3    CALML3
    CALML4

    MYL7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/173 SNPs in MYL7 are shown (see all 173)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1878760421,2
    --44177973(+) AAAGGA/GCCCAT 1 -- int10--------
    rs1113539781,2
    F--44178088(+) GGGCTA/G/TTTGGG 1 -- int12CSA 3
    rs1396689331,2
    --44178343(+) CTGGCA/GAGGGG 1 -- int10--------
    rs799024001,2
    C,F--44178393(+) ATGTGC/TGCACT 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1926758931,2
    --44178402(+) CTGAGA/GCCCTG 1 -- int10--------
    rs1845018801,2
    --44178462(+) CAGCAA/GTTCCA 1 -- spd10--------
    rs750183911,2
    C--44178498(+) GCCCCA/C/GCCGTG 2 -- ut311WA 118
    rs1418526361,2
    F--44178535(+) TTCTCG/ATCTCC 2 /D syn11Minor allele frequency- A:0.00NA 4552
    rs1506229901,2
    C,F--44178576(+) GTCGAT/CGTTCC 2 /I /V mis11Minor allele frequency- C:0.00NA 4552
    rs1387100661,2
    C--44178583(+) TTCCCC/G/TGCCAG 3 A syn11NA 4552

    HapMap Linkage Disequilibrium report for MYL7 (44178463 - 44180931 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MYL7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv887996CNV Loss21882294
    nsv470210CNV Loss18288195
    nsv830983CNV Loss17160897
    nsv428165CNV Gain18775914
    nsv8082CNV Gain18304495

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613993    OMIM disorders: --

    3 diseases for MYL7:    About MalaCards
    endometritis    hypertrophic cardiomyopathy    down syndrome

    1 disease from the University of Copenhagen DISEASES database for MYL7:
    Endometritis

    MYL7 for disorders           About GeneDecksing


    Export disorders for MYL7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYL7 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with MYL7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis. (PubMed id 8207020)1, 3, 9 Kubalak S.W....Chien K.R. (1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development. (PubMed id 1429676)1, 2 Hailstones D.L.... Gunning P.W. (1992)
    4. Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain en dothelial cells. (PubMed id 19794400)1 Zhong Y....Toborek M. (2010)
    5. [Expression and function of non-muscle myosin-IIA in Fechtner syndrome] (PubMed id 18718080)1 Yang H.Y....Ruan C.G. (2008)
    6. Mutation in myosin heavy chain 6 causes atrial septal defect. (PubMed id 15735645)1 Ching Y.-H.... Brook J.D. (2005)
    7. Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium. (PubMed id 15621049)1 Grimm M....Eschenhagen T. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    9. Functional divergence of human cytoplasmic myosin II: kinetic characterization of the non-muscle IIA isoform. (PubMed id 12847096)1 Kovacs M....Sellers J.R. (2003)
    10. The human adult cardiomyocyte phenotype. (PubMed id 12757876)1 Bird S.D....Mummery C.L. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58498 HGNC: 21719 AceView: MYL7 Ensembl:ENSG00000106631 euGenes: HUgn58498
    ECgene: MYL7 Kegg: 58498 H-InvDB: MYL7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYL7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYL7 gene:
    Search GeneIP for patents involving MYL7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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