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MYL7 Gene

protein-coding   GIFtS: 59
GCID: GC07M044178

Myosin, Light Chain 7, Regulatory

(Previous names: myosin, light polypeptide 7, regulatory)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin, Light Chain 7, Regulatory1 2     Myosin Regulatory Light Chain 72 3
MYL2A2 3 5     MLC-2a2 3
MYLC2A2 3 5     MLC2a2 3
Myosin, Light Polypeptide 7, Regulatory1 2     Myosin Regulatory Light Chain 2, Atrial Isoform2
Myosin Light Chain 2a2 3     MLC2A5

External Ids:    HGNC: 217191   Entrez Gene: 584982   Ensembl: ENSG000001066317   OMIM: 6139935   UniProtKB: Q014493   

Export aliases for MYL7 gene to outside databases

Previous GC identifers: GC00U912966 GC07M043919 GC07M043951 GC07M044144 GC07M044063


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYL7 Gene:
MYL7 (myosin, light chain 7, regulatory) is a protein-coding gene. GO annotations related to this gene include ATPase activity, coupled and calcium ion binding. An important paralog of this gene is MYL12A.

summary for MYL7 Gene:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYL7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYL7 gene promoter:
         COUP-TF1   COUP-TF   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYL7 promoter sequence
   Search Chromatin IP Primers for MYL7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYL7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21-p11.2   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p21-p11.2

MYL7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL7 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M044178:  view genomic region     (about GC identifiers)

Start:
44,178,463 bp from pter      End:
44,180,931 bp from pter
Size:
2,469 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 44,217,962-44,220,416     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MLRA_HUMAN, Q01449 (See protein sequence)
Recommended Name: Myosin regulatory light chain 2, atrial isoform  
Size: 175 amino acids; 19448 Da
Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains
Miscellaneous: This chain binds calcium
Secondary accessions: B2R4L3

Explore the universe of human proteins at neXtProt for MYL7: NX_Q01449

Explore proteomics data for MYL7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYL7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067046.1  
    ENSEMBL proteins: 
     ENSP00000416010   ENSP00000223364   ENSP00000403360   ENSP00000389202   ENSP00000403988  
     ENSP00000399398   ENSP00000411340   ENSP00000404918  

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    Cloud-Clone Corp. Proteins for MYL7

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing
    MYL: Myosins / Light chain

    3 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q01449

    ProtoNet protein and cluster: Q01449

    UniProtKB/Swiss-Prot: MLRA_HUMAN, Q01449
    Similarity: Contains 3 EF-hand domains


    Find genes that share domains with MYL7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000146microfilament motor activity ----
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0042623ATPase activity, coupled ----
         
    Find genes that share ontologies with MYL7           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Myl7):
     cardiovascular system  cellular  embryogenesis  growth/size/body  homeostasis/metabolism 
     mortality/aging  muscle 

    Find genes that share phenotypes with MYL7           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYL7
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    mitochondrion2
    nucleus2
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016459myosin complex NAS1429676
    GO:0031672A band IDA15621049
    GO:0043197dendritic spine IEA--

    Find genes that share ontologies with MYL7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYL7 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    3Cell adhesion Integrin mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Development MAG dependent inhibition of neurite outgrowth0.46
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cell adhesion Tight junctions0.33
    4PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    5Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35


    Find genes that share SuperPaths with MYL7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYL7 (see all 16)
        Activation of PKA through GPCR
    RhoA Pathway
    PKA Signaling
    Guidance Cues and Growth Cone Motility
    Antioxidant Action of Vitamin-C

    Selected GeneGo (Thomson Reuters) Pathways for MYL7 (see all 6)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Tight junctions


    4 Kegg Pathways  (Kegg details for MYL7):
        Focal adhesion
    Tight junction
    Leukocyte transendothelial migration
    Regulation of actin cytoskeleton

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYL7
    Interactions:

        Search GeneGlobe Interaction Network for MYL7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for MYL7 (Q014493 ENSP000002233644) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYH6P135333I2D: score=1 
    ACTBENSP000003499604STRING: ENSP00000349960
    ACTG1ENSP000003315144STRING: ENSP00000331514
    CGNENSP000002716364STRING: ENSP00000271636
    MYH10ENSP000002692434STRING: ENSP00000269243
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    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006939smooth muscle contraction ----
    GO:0030048actin filament-based movement ----

    Find genes that share ontologies with MYL7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MYL7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BTSSelective inhibitor of skeletal muscle myosin II ATPase activity[1576-37-0]
    (R)-(+)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)[1177356-70-5]
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)[856925-71-8]
    (+-)-BlebbistatinSelective inhibitor of myosin II ATPase activity[674289-55-5]

    1 HMDB Compound for MYL7    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYL7 gene: 
    NM_021223.2  

    Unigene Cluster for MYL7:

    Myosin, light chain 7, regulatory
    Hs.75636  [show with all ESTs]
    Unigene Representative Sequence: BI836837
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000446581 ENST00000223364(uc003tkg.3) ENST00000458240 ENST00000434895
    ENST00000457314 ENST00000447951 ENST00000476118 ENST00000431289 ENST00000431007
    ENST00000457910
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    Additional mRNA sequence: 

    AK311869.1 BC027915.1 M94547.1 

    20 DOTS entries:

    DT.450936  DT.91660291  DT.95084864  DT.87078096  DT.100754736  DT.100754737  DT.121061744  DT.91660254 
    DT.95371985  DT.95372000  DT.121061729  DT.95371983  DT.40292489  DT.102826012  DT.121061722  DT.121061728 
    DT.91660294  DT.95371995  DT.95371996  DT.121061740 

    Selected AceView cDNA sequences (see all 335):

    AA247462 AJ709502 BQ445851 C05145 N86069 NM_021223 T28710 AA347095 
    AA248626 AA248691 AA346344 AA247791 AJ712021 AI355734 AA247745 AA249277 
    AI333507 BX501516 AJ708771 BC027915 N86275 AJ706807 AI332570 AJ711909 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MYL7 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7
    SP1:                                      -     -                       -           -         
    SP2:                          -           -     -                       -           -         
    SP3:                                      -     -                       -     -     -         
    SP4:                                      -     -                                   -         
    SP5:                          -           -                                                   


    ECgene alternative splicing isoforms for MYL7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYL7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGACGAGAA
    MYL7 Expression
    About this image


    MYL7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 21 entries
             Cardiac Crescent Cells Cardiac Crescent
             Left Atrium
             Cardiac progenitor cells (Sca1+)
             Cardiomyocyte-like progenitor cells
     
     NULL (Uncategorized)    fully expand to see all 8 entries
             Cardiac mesoderm embryoid bodies
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             hIPS1
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
    MYL7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYL7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75636

    UniProtKB/Swiss-Prot: MLRA_HUMAN, Q01449
    Tissue specificity: Predominantly expressed in adult atrial muscle

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MYL7 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myl71 , 5 myosin, light polypeptide 7, regulatory1, 5 88.95(n)1
    95.43(a)1
      11 (3.88 cM)5
    178981  NM_022879.21  NP_075017.21 
     58966375 
    African clawed frog
    (Xenopus laevis)
    Amphibia mylc2a-prov2 myosin light chain, regulatory A 79.41(n)    Z33999.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mylc2a2 myosin light chain, regulatory A 75.19(n)   30592  AY057074.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mlc26
    CG330986
    --
    31(a)
    21(a)
    1 ↔ many
    1 ↔ many
    3R(25997160-26000273)
    3R(8212910-8214517)
    worm
    (Caenorhabditis elegans)
    Secernentea mlc-16
    mlc-26
    Protein MLC-2 (mlc-2) mRNA, complete cds
    42(a)
    42(a)
    1 ↔ many
    1 ↔ many
    X(17459160-17460767) WBGene00003369
    X(17455779-17456586) WBGene00003370


    ENSEMBL Gene Tree for MYL7 (if available)
    TreeFam Gene Tree for MYL7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYL7 gene
    MYL12A2  MYL102  MYL92  MYL52  MYL22  MYLPF2  MYL12B2  
    12 SIMAP similar genes for MYL7 using alignment to 8 protein entries:     MLRA_HUMAN (see all proteins):
    MYL5    MYLPF    MYL12A    MYL9    MYL12B    MYL2
    MYL10    CALM2    CALM1    CALM3    CALML3    CALML4

    Find genes that share paralogs with MYL7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYL7 (see all 173)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1878760421,2
    --44177973(+) AAAGGA/GCCCAT 1 -- int10--------
    rs1113539781,2
    F--44178088(+) GGGCTA/G/TTTGGG 1 -- int12CSA 3
    rs1396689331,2
    --44178343(+) CTGGCA/GAGGGG 1 -- int10--------
    rs799024001,2
    C,F--44178393(+) ATGTGC/TGCACT 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1926758931,2
    --44178402(+) CTGAGA/GCCCTG 1 -- int10--------
    rs1845018801,2
    --44178462(+) CAGCAA/GTTCCA 1 -- spd10--------
    rs750183911,2
    C--44178498(+) GCCCCA/C/GCCGTG 2 -- ut311WA 118
    rs1418526361,2
    F--44178535(+) TTCTCG/ATCTCC 2 /D syn11Minor allele frequency- A:0.00NA 4552
    rs1506229901,2
    C,F--44178576(+) GTCGAT/CGTTCC 2 /I /V mis11Minor allele frequency- C:0.00NA 4552
    rs1387100661,2
    C--44178583(+) TTCCCC/G/TGCCAG 3 A syn11NA 4552

    HapMap Linkage Disequilibrium report for MYL7 (44178463 - 44180931 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MYL7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv887996CNV Loss21882294
    nsv470210CNV Loss18288195
    nsv830983CNV Loss17160897
    nsv428165CNV Gain18775914
    nsv8082CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MYL7
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613993    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for MYL7:
    Endometritis

    Find genes that share disorders with MYL7           About GenesLikeMe


    Export disorders for MYL7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYL7 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with MYL7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis. (PubMed id 8207020)1, 3, 9 Kubalak S.W....Chien K.R. (J. Biol. Chem. 1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development. (PubMed id 1429676)1, 2 Hailstones D.L.... Gunning P.W. (J. Biol. Chem. 1992)
    4. Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain endothelial cells. (PubMed id 19794400)1 Zhong Y....Toborek M. (J. Cereb. Blood Flow Metab. 2010)
    5. [Expression and function of non-muscle myosin-IIA in Fechtner syndrome]. (PubMed id 18718080)1 Yang H.Y....Ruan C.G. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008)
    6. Mutation in myosin heavy chain 6 causes atrial septal defect. (PubMed id 15735645)1 Ching Y.-H.... Brook J.D. (Nat. Genet. 2005)
    7. Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium. (PubMed id 15621049)1 Grimm M....Eschenhagen T. (Cardiovasc. Res. 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Functional divergence of human cytoplasmic myosin II: kinetic characterization of the non-muscle IIA isoform. (PubMed id 12847096)1 KovA!cs M....Sellers J.R. (J. Biol. Chem. 2003)
    10. The human adult cardiomyocyte phenotype. (PubMed id 12757876)1 Bird S.D....Mummery C.L. (Cardiovasc. Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 58498 HGNC: 21719 AceView: MYL7 Ensembl:ENSG00000106631 euGenes: HUgn58498
    ECgene: MYL7 Kegg: 58498 H-InvDB: MYL7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYL7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYL7 gene:
    Search GeneIP for patents involving MYL7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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