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Aliases for MYL6B Gene

Aliases for MYL6B Gene

  • Myosin Light Chain 6B 2 3 5
  • Myosin, Light Polypeptide 6B, Alkali, Smooth Muscle And Non-Muscle 2 3
  • Myosin, Light Chain 6B, Alkali, Smooth Muscle And Non-Muscle 2 3
  • Smooth Muscle And Nonmuscle Myosin Light Chain Alkali 6B 3 4
  • Myosin Light Chain 1 Slow A 2 3
  • MLC1SA 3 4
  • Smooth Muscle And Non-Muscle Myosin Alkali Light Chain 6B 3
  • Myosin Light Chain 1, Slow-Twitch Muscle A Isoform 3
  • Myosin Light Chain 1 Slow-Twitch Muscle A Isoform 4
  • Myosin Alkali Light Chain 1 Slow A 3

External Ids for MYL6B Gene

Previous GeneCards Identifiers for MYL6B Gene

  • GC12P054836
  • GC12P056546
  • GC12P053585

Summaries for MYL6B Gene

Entrez Gene Summary for MYL6B Gene

  • Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

GeneCards Summary for MYL6B Gene

MYL6B (Myosin Light Chain 6B) is a Protein Coding gene. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and fMLP Pathway. GO annotations related to this gene include calcium ion binding and structural constituent of muscle. An important paralog of this gene is MYL1.

UniProtKB/Swiss-Prot for MYL6B Gene

  • Regulatory light chain of myosin. Does not bind calcium.

Gene Wiki entry for MYL6B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL6B Gene

Genomics for MYL6B Gene

Regulatory Elements for MYL6B Gene

Enhancers for MYL6B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F056192 0.5 Ensembl ENCODE 18.8 +40.9 40885 1.1 HDGF TBP NFRKB ZNF133 ARID4B ZNF2 RAD21 YY1 SCRT2 ZNF143 ENSG00000258199 NABP2 MYL6B ENSG00000257740 RNF41 SLC39A5 SMARCC2 MYL6 GC12P056195 TRS-CGA4-1
GH12F056124 0.4 ENCODE 13.1 -24.3 -24261 6.2 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SSRP1 NEMP1 BAZ2A MYL6B ENSG00000258199 MYL6 SMARCC2 RN7SL809P NABP2 RNF41 COQ10A
GH12F056501 0.4 Ensembl 10 +349.2 349151 0.6 ZNF121 CTCF RAD51 RBMS2 RNU6-343P SPRYD4 COQ10A ANKRD52 BAZ2A NABP2 RNF41 SLC39A5 MYL6
GH12F056220 0.4 ENCODE 8.7 +70.6 70626 5.7 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 NEMP1 ANKRD52 BAZ2A PHC1P1 ZBTB39 TMEM198B SMARCC2 RN7SL809P ENSG00000258317 STAT2
GH12F056196 0.6 Ensembl ENCODE 8.4 +44.8 44794 1.6 HDGF PKNOX1 TBL1XR1 INSM2 KLF17 FEZF1 RAD21 ZNF2 ZEB1 ZNF366 OR10A7 OR6C74 RNF41 NABP2 SLC39A5 ANKRD52 COQ10A PA2G4 MYL6B RPS26
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MYL6B on UCSC Golden Path with GeneCards custom track

Promoters for MYL6B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000088816 44 1401 CREB3L1 WRNIP1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF207 ZNF143 FOS

Genomic Location for MYL6B Gene

56,152,256 bp from pter
56,159,647 bp from pter
7,392 bases
Plus strand

Genomic View for MYL6B Gene

Genes around MYL6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYL6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYL6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL6B Gene

Proteins for MYL6B Gene

  • Protein details for MYL6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myosin light chain 6B
    Protein Accession:

    Protein attributes for MYL6B Gene

    208 amino acids
    Molecular mass:
    22764 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains.

    Three dimensional structures from OCA and Proteopedia for MYL6B Gene

neXtProt entry for MYL6B Gene

Post-translational modifications for MYL6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYL6B Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for MYL6B
  • Santa Cruz Biotechnology (SCBT) Antibodies for MYL6B

No data available for DME Specific Peptides for MYL6B Gene

Domains & Families for MYL6B Gene

Gene Families for MYL6B Gene

Protein Domains for MYL6B Gene

Suggested Antigen Peptide Sequences for MYL6B Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 EF-hand domains.
  • Contains 3 EF-hand domains.
genes like me logo Genes that share domains with MYL6B: view

Function for MYL6B Gene

Molecular function for MYL6B Gene

UniProtKB/Swiss-Prot Function:
Regulatory light chain of myosin. Does not bind calcium.

Gene Ontology (GO) - Molecular Function for MYL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity TAS 2304459
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 15510214
GO:0008307 structural constituent of muscle TAS 2304459
genes like me logo Genes that share ontologies with MYL6B: view
genes like me logo Genes that share phenotypes with MYL6B: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYL6B Gene

Localization for MYL6B Gene

Subcellular locations from

Jensen Localization Image for MYL6B Gene COMPARTMENTS Subcellular localization image for MYL6B gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MYL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005859 muscle myosin complex TAS 2458299
GO:0016459 myosin complex IEA,TAS 2304459
GO:0016461 unconventional myosin complex TAS 2304459
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with MYL6B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYL6B Gene

Pathways & Interactions for MYL6B Gene

genes like me logo Genes that share pathways with MYL6B: view

Interacting Proteins for MYL6B Gene

SIGNOR curated interactions for MYL6B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MYL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 2304459
GO:0007519 skeletal muscle tissue development TAS 2304459
GO:0030049 muscle filament sliding TAS 2304459
genes like me logo Genes that share ontologies with MYL6B: view

Drugs & Compounds for MYL6B Gene

(2) Drugs for MYL6B Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with MYL6B: view

Transcripts for MYL6B Gene

Unigene Clusters for MYL6B Gene

Myosin, light chain 6B, alkali, smooth muscle and non-muscle:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYL6B Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8
SP1: - - -
SP2: -
SP4: -

Relevant External Links for MYL6B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYL6B Gene

mRNA expression in normal human tissues for MYL6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYL6B Gene

This gene is overexpressed in Muscle - Skeletal (x9.1).

Protein differential expression in normal tissues from HIPED for MYL6B Gene

This gene is overexpressed in Neutrophil (12.6), Nasal epithelium (8.3), Blymphocyte (7.8), Esophagus (6.5), and Cervix (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYL6B Gene

NURSA nuclear receptor signaling pathways regulating expression of MYL6B Gene:


SOURCE GeneReport for Unigene cluster for MYL6B Gene:

genes like me logo Genes that share expression patterns with MYL6B: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MYL6B Gene

Orthologs for MYL6B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYL6B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MYL6B 34 35
  • 99.52 (n)
(Mus musculus)
Mammalia Myl6b 34 16 35
  • 88.57 (n)
(Canis familiaris)
Mammalia MYL6B 34 35
  • 86.22 (n)
(Rattus norvegicus)
Mammalia RGD1560334 34
  • 86.15 (n)
(Bos Taurus)
Mammalia MYL6B 34 35
  • 84.78 (n)
(Anolis carolinensis)
Reptilia MYL6B 35
  • 74 (a)
(Danio rerio)
Actinopterygii myl6 35
  • 66 (a)
zgc:153867 35
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mlc-c 35
  • 52 (a)
(Caenorhabditis elegans)
Secernentea mlc-5 35
  • 47 (a)
mlc-6 35
  • 45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MLC1 35
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.211 35
  • 53 (a)
CSA.4806 35
  • 44 (a)
CSA.6288 35
  • 44 (a)
CSA.6678 35
  • 44 (a)
Species where no ortholog for MYL6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MYL6B Gene

Gene Tree for MYL6B (if available)
Gene Tree for MYL6B (if available)

Paralogs for MYL6B Gene

Paralogs for MYL6B Gene

(11) SIMAP similar genes for MYL6B Gene using alignment to 3 proteins: Pseudogenes for MYL6B Gene

genes like me logo Genes that share paralogs with MYL6B: view

Variants for MYL6B Gene

Sequence variations from dbSNP and Humsavar for MYL6B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs111602323 -- 56,156,806(+) AGCAT(A/T)TTGGG intron-variant, upstream-variant-2KB
rs111759183 -- 56,158,406(+) GATGG(G/T)GGGGC downstream-variant-500B, splice-donor-variant
rs112084821 -- 56,155,137(+) AGGGC(A/C)CTGGG reference, synonymous-codon
rs112353649 -- 56,155,098(+) GATGG(A/C)AAGAT reference, synonymous-codon
rs112387717 -- 56,154,016(+) AGCCA(A/G)GACCA downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MYL6B Gene

Variant ID Type Subtype PubMed ID
dgv2648n54 CNV loss 21841781
nsv1051961 CNV gain 25217958
nsv559013 CNV loss 21841781

Variation tolerance for MYL6B Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYL6B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYL6B Gene

Disorders for MYL6B Gene

Relevant External Links for MYL6B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MYL6B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYL6B Gene

Publications for MYL6B Gene

  1. Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. (PMID: 2304459) Hailstones D.L. … Gunning P.W. (Mol. Cell. Biol. 1990) 2 3 4 22 64
  2. A novel isoform of myosin alkali light chain isolated from human muscle cells. (PMID: 2602161) Zimmermann K. … Starzinski-Powitz A. (Nucleic Acids Res. 1989) 2 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for MYL6B Gene

Sources for MYL6B Gene

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