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MYL6B Gene

protein-coding   GIFtS: 62
GCID: GC12P056546

Myosin, Light Chain 6B, Alkali, Smooth Muscle And Non-Muscle

(Previous names: myosin, light polypeptide 6B, alkali, smooth muscle and...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Myosin, Light Chain 6B, Alkali, Smooth Muscle And Non-Muscle1 2     Myosin Alkali Light Chain 1 Slow A2
MLC1SA2 3 5     Myosin Light Chain 1, Slow-Twitch Muscle A Isoform2
Myosin, Light Polypeptide 6B, Alkali, Smooth Muscle And Non-Muscle1 2     Myosin Light Chain 6B2
Myosin Light Chain 1 Slow A1 2     Smooth Muscle And Non-Muscle Myosin Alkali Light Chain 6B2
Myosin Light Chain 1 Slow-Twitch Muscle A Isoform2 3     MLC1sa3
Smooth Muscle And Nonmuscle Myosin Light Chain Alkali 6B2 3     

External Ids:    HGNC: 298231   Entrez Gene: 1404652   Ensembl: ENSG000001964657   OMIM: 6099305   UniProtKB: P146493   
ORGUL members:         

Export aliases for MYL6B gene to outside databases

Previous GC identifers: GC12P054836 GC12P053585


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYL6B Gene:
Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable
alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light
chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Dec 2010)

GeneCards Summary for MYL6B Gene:
MYL6B (myosin, light chain 6B, alkali, smooth muscle and non-muscle) is a protein-coding gene. GO annotations related to this gene include motor activity and calcium ion binding. An important paralog of this gene is MYL4.

UniProtKB/Swiss-Prot: MYL6B_HUMAN, P14649
Function: Regulatory light chain of myosin. Does not bind calcium

Gene Wiki entry for MYL6B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYL6B gene promoter:
         SRF   SRF (504 AA)   Pax-2   Pax-2a   Nkx2-5   MIF-1   Tal-1beta   YY1   AREB6   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYL6B promoter sequence
   Search Chromatin IP Primers for MYL6B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYL6B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13.2

MYL6B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL6B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P056546:  view genomic region     (about GC identifiers)

Start:
56,546,040 bp from pter      End:
56,553,431 bp from pter
Size:
7,392 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MYL6B_HUMAN, P14649 (See protein sequence)
Recommended Name: Myosin light chain 6B  
Size: 208 amino acids; 22764 Da
Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains
3 PDB 3D structures from and Proteopedia for MYL6B:
1OE9 (3D)        1W7I (3D)        1W7J (3D)    

Explore the universe of human proteins at neXtProt for MYL6B: NX_P14649

Explore proteomics data for MYL6B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys107
  • Modification sites at PhosphoSitePlus

  • See MYL6B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186558.1  NP_002466.1  

    ENSEMBL proteins: 
     ENSP00000450385   ENSP00000446643   ENSP00000448198   ENSP00000446965   ENSP00000207437  
    Reactome Protein details: P14649

    MYL6B Human Recombinant Protein Products:

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    antibodies-online peptides for MYL6B

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing
    MYL: Myosins / Light chain

    2 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom

    Graphical View of Domain Structure for InterPro Entry P14649

    ProtoNet protein and cluster: P14649

    UniProtKB/Swiss-Prot: MYL6B_HUMAN, P14649
    Similarity: Contains 3 EF-hand domains


    Find genes that share domains with MYL6B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYL6B_HUMAN, P14649
    Function: Regulatory light chain of myosin. Does not bind calcium

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity TAS2304459
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI15510214
    GO:0008307structural constituent of muscle TAS2304459
         
    Find genes that share ontologies with MYL6B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MYL6B:
     Increased cilium length after  

    Animal Models:
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    miRNA
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    hsa-miR-3914
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    nucleus2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005859muscle myosin complex TAS2458299
    GO:0016459myosin complex TAS2304459
    GO:0016461unconventional myosin complex TAS2304459

    Find genes that share ontologies with MYL6B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYL6B About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    2Cell adhesion Integrin mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Development MAG dependent inhibition of neurite outgrowth0.46
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cell adhesion Tight junctions0.33
    3Striated Muscle Contraction
    Muscle contraction0.61
    Smooth Muscle Contraction0.47
    4Oxytocin signaling pathway
    Oxytocin signaling pathway0.32
    Vascular smooth muscle contraction0.32
    5fMLP Pathway
    Signal transduction Activation of PKC via G Protein coupled receptor0.42


    Find genes that share SuperPaths with MYL6B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for MYL6B (see all 8)
        Signal transduction Activation of PKC via G-Protein coupled receptor
    Cell adhesion Integrin-mediated cell adhesion and migration
    Inhibitory action of Lipoxins on neutrophil migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils

    1 Reactome Pathway for MYL6B
        Smooth Muscle Contraction


    2 Kegg Pathways  (Kegg details for MYL6B):
        Vascular smooth muscle contraction
    Oxytocin signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYL6B
    Interactions:

        Search GeneGlobe Interaction Network for MYL6B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYL6B (P146491, 2, 3 ENSP000002074374) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RIPK3Q9Y5722, 3MINT-49117 I2D: score=2 
    USP46P620683, ENSP000004078184I2D: score=1 STRING: ENSP00000407818
    IQGAP1P469403, ENSP000002681824I2D: score=1 STRING: ENSP00000268182
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    MYO5AQ9Y4I13I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction TAS2304459
    GO:0007519skeletal muscle tissue development TAS2304459
    GO:0008152metabolic process TAS2304459
    GO:0030049muscle filament sliding TAS2304459

    Find genes that share ontologies with MYL6B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MYL6B

    1 HMDB Compound for MYL6B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for MYL6B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYL6B gene (2 alternative transcripts): 
    NM_001199629.1  NM_002475.4  

    Unigene Cluster for MYL6B:

    Myosin, light chain 6B, alkali, smooth muscle and non-muscle
    Hs.632731  [show with all ESTs]
    Unigene Representative Sequence: BU587399
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553066(uc001sjs.3) ENST00000550443(uc001sjt.3) ENST00000551834
    ENST00000405661(uc009zoo.3) ENST00000552568 ENST00000550152 ENST00000549178
    ENST00000548548 ENST00000550550 ENST00000548571 ENST00000549380 ENST00000207437

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    hsa-miR-3914
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    Additional mRNA sequence: 

    BC012425.1 BC014400.1 M31211.1 X16434.1 

    14 DOTS entries:

    DT.100817725  DT.92426265  DT.414610  DT.91906551  DT.100817722  DT.414611  DT.95171399  DT.100036945 
    DT.91711075  DT.121141041  DT.102840320  DT.95171406  DT.100799372  DT.91901928 

    Selected AceView cDNA sequences (see all 2991):

    AW573552 CA772264 AI884555 CA866420 BM142648 AA348971 BG697776 BM463741 
    AL047901 CB178526 N20481 CF129404 AA368989 BQ447056 CB109321 BM697438 
    BE908050 BM696683 AL600764 AU107271 BM768924 CA949990 BE796846 BQ631459 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MYL6B (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8
    SP1:        -     -     -                                                                     
    SP2:                                                                          -               
    SP3:                                                                                          
    SP4:        -                                                                                 
    SP5:                                                                                          


    ECgene alternative splicing isoforms for MYL6B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYL6B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTCACCAC
    MYL6B Expression
    About this image


    MYL6B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord
    MYL6B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYL6B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632731
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL6B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYL6B gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myl6b1 , 5 myosin, light polypeptide 6B1, 5 88.57(n)1
    89.86(a)1
      10 (76.77 cM)5
    2164591  NM_172259.11  NP_758463.11 
     1284941575 
    lizard
    (Anolis carolinensis)
    Reptilia MYL6B6
    myosin, light chain 6B, alkali, smooth muscle and ...
    74(a)
    1 ↔ 1
    2(93830115-93844094)
    zebrafish
    (Danio rerio)
    Actinopterygii myl66
    zgc:1538676
    zgc:153867
    66(a)
    61(a)
    many ↔ many
    many ↔ many
    6(39805041-39824390) ENSDARG00000008494
    23(28617350-28631405) ENSDARG00000033738
    fruit fly
    (Drosophila melanogaster)
    Insecta Mlc-c6
    Myosin light chain cytoplasmic
    52(a)
    1 → many
    X(5513169-5516591)
    worm
    (Caenorhabditis elegans)
    Secernentea mlc-56
    mlc-66
    Protein K04C1.4 (K04C1.4) mRNA, complete cds
    47(a)
    45(a)
    many ↔ many
    many ↔ many
    III(13623293-13624172) WBGene00011734
    X(14245732-14246611) WBGene00010554
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MLC1(YGL106W)4 Essential light chain for Myo1p, light chain for Myo2p; more   --   7(306560-307009) 852772  NP_011409.1 


    ENSEMBL Gene Tree for MYL6B (if available)
    TreeFam Gene Tree for MYL6B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYL6B gene
    MYL42  MYL12  MYL62  MYL32  
    11 SIMAP similar genes for MYL6B using alignment to 3 protein entries:     MYL6B_HUMAN (see all proteins):
    MYL6    MYL1    MYL3    MYL4    CALML3    CALM1
    CALM3    CALM2    TNNC2    TNNC1    CABP2

    Find genes that share paralogs with MYL6B           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for MYL6B
    PGOHUM00000249156 PGOHUM00000240510


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYL6B (see all 120)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1856139701,2
    --56544368(+) TATGCC/TCAGTT 2 -- us2k10--------
    rs762466781,2
    C--56544445(+) TAGCCC/TTCCCA 2 -- us2k10--------
    rs780436251,2
    F--56544469(+) CTTAAC/TGTTTT 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1168097581,2
    C,F--56544587(+) AAGAGC/ACATAT 2 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1900299181,2
    --56544630(+) CCACAC/TAAAGG 2 -- us2k10--------
    rs1478451061,2
    --56544684(+) ATGTAC/TTCCTT 2 -- us2k10--------
    rs1823619621,2
    --56544723(+) TTGATA/CCTTAC 2 -- us2k10--------
    rs1859291791,2
    --56544775(+) CTTGGA/GAAGAT 2 -- us2k10--------
    rs1908611901,2
    --56544894(+) GGCTGA/GAGTGC 2 -- us2k10--------
    rs584767351,2
    C--56544907(+) TGGTGC/GGATCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MYL6B (56546040 - 56553431 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MYL6B: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYL6B
    DNA2.0 Custom Variant and Variant Library Synthesis for MYL6B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609930    OMIM disorders: --


    Find genes that share disorders with MYL6B           About GenesLikeMe


    Export disorders for MYL6B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYL6B gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with MYL6B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. (PubMed id 2304459)1, 2, 3, 9 Hailstones D.L. and Gunning P.W. (Mol. Cell. Biol. 1990)
    2. A novel isoform of myosin alkali light chain isolated from human muscle cells. (PubMed id 2602161)1, 2, 3 Zimmermann K. and Starzinski-Powitz A. (Nucleic Acids Res. 1989)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    5. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)1 Chuang J.Y....Hung J.J. (Oncogene 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47. (PubMed id 22354994)1 Teachenor R....Murre C. (Mol. Cell. Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140465 HGNC: 29823 AceView: MLC1SAandMYL6 Ensembl:ENSG00000196465 euGenes: HUgn140465
    ECgene: MYL6B Kegg: 140465 H-InvDB: MYL6B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYL6B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYL6B gene:
    Search GeneIP for patents involving MYL6B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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