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Aliases for MYL6B Gene

Aliases for MYL6B Gene

  • Myosin Light Chain 6B 2 3 5
  • Myosin, Light Polypeptide 6B, Alkali, Smooth Muscle And Non-Muscle 2 3
  • Myosin, Light Chain 6B, Alkali, Smooth Muscle And Non-Muscle 2 3
  • Smooth Muscle And Nonmuscle Myosin Light Chain Alkali 6B 3 4
  • Myosin Light Chain 1 Slow A 2 3
  • MLC1SA 3 4
  • Smooth Muscle And Non-Muscle Myosin Alkali Light Chain 6B 3
  • Myosin Light Chain 1, Slow-Twitch Muscle A Isoform 3
  • Myosin Light Chain 1 Slow-Twitch Muscle A Isoform 4
  • Myosin Alkali Light Chain 1 Slow A 3

External Ids for MYL6B Gene

Previous GeneCards Identifiers for MYL6B Gene

  • GC12P054836
  • GC12P056546
  • GC12P053585

Summaries for MYL6B Gene

Entrez Gene Summary for MYL6B Gene

  • Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

GeneCards Summary for MYL6B Gene

MYL6B (Myosin Light Chain 6B) is a Protein Coding gene. Among its related pathways are Aquaporin-mediated transport and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include calcium ion binding and structural constituent of muscle. An important paralog of this gene is MYL1.

UniProtKB/Swiss-Prot for MYL6B Gene

  • Regulatory light chain of myosin. Does not bind calcium.

Gene Wiki entry for MYL6B Gene

Additional gene information for MYL6B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL6B Gene

Genomics for MYL6B Gene

Regulatory Elements for MYL6B Gene

Enhancers for MYL6B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H056192 1.2 Ensembl ENCODE 18.8 +40.9 40885 1 TBP HDGF NFRKB ZNF133 ARID4B ZNF2 RAD21 YY1 ZNF766 SCRT2 MYL6B RNF41 NABP2 SLC39A5 MYL6 TRS-CGA4-1 GC12P056195
GH12H056124 1.4 ENCODE dbSUPER 13.1 -24.3 -24261 6 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 ZNF610 NEMP1 BAZ2A SMARCC2 DNAJC14 MYL6 PYM1 ENSG00000258199 RN7SL809P ZBTB39 ZC3H10
GH12H056220 1.4 ENCODE dbSUPER 8.7 +70.6 70626 5 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NEMP1 BAZ2A PAN2 DNAJC14 ZBTB39 ANKRD52 PHC1P1 TMEM198B ENSG00000258317 ZC3H10
GH12H056358 1.5 FANTOM5 ENCODE 7.8 +207.6 207629 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 ZC3H10 STAT2 BAZ2A ENSG00000257303 ENSG00000258317 IL23A PAN2 NEMP1 DNAJC14 ZBTB39
GH12H056196 1.1 Ensembl ENCODE 8.4 +44.8 44794 1 INSM2 KLF17 FEZF1 ZNF2 ZEB1 ZNF366 ZNF362 TSHZ1 ZEB2 ZNF645 SMARCC2 OR10A7 OR6C74 RNF41 NABP2 SLC39A5 ANKRD52 COQ10A ENSG00000258199 ENSG00000257740
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYL6B on UCSC Golden Path with GeneCards custom track

Promoters for MYL6B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052483 144 1201 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF207 ZNF143 FOS

Genomic Location for MYL6B Gene

Chromosome:
12
Start:
56,152,256 bp from pter
End:
56,159,647 bp from pter
Size:
7,392 bases
Orientation:
Plus strand

Genomic View for MYL6B Gene

Genes around MYL6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYL6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYL6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL6B Gene

Proteins for MYL6B Gene

  • Protein details for MYL6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14649-MYL6B_HUMAN
    Recommended name:
    Myosin light chain 6B
    Protein Accession:
    P14649

    Protein attributes for MYL6B Gene

    Size:
    208 amino acids
    Molecular mass:
    22764 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains.

    Three dimensional structures from OCA and Proteopedia for MYL6B Gene

neXtProt entry for MYL6B Gene

Post-translational modifications for MYL6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYL6B Gene

No data available for DME Specific Peptides for MYL6B Gene

Domains & Families for MYL6B Gene

Gene Families for MYL6B Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MYL6B Gene

Suggested Antigen Peptide Sequences for MYL6B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYL6B: view

No data available for UniProtKB/Swiss-Prot for MYL6B Gene

Function for MYL6B Gene

Molecular function for MYL6B Gene

UniProtKB/Swiss-Prot Function:
Regulatory light chain of myosin. Does not bind calcium.

Gene Ontology (GO) - Molecular Function for MYL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity TAS 2304459
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 15510214
GO:0008307 structural constituent of muscle TAS 2304459
genes like me logo Genes that share ontologies with MYL6B: view
genes like me logo Genes that share phenotypes with MYL6B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MYL6B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYL6B Gene

Localization for MYL6B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYL6B gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MYL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005859 muscle myosin complex TAS 2458299
GO:0016459 myosin complex TAS 2304459
GO:0016461 unconventional myosin complex TAS 2304459
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with MYL6B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYL6B Gene

Pathways & Interactions for MYL6B Gene

genes like me logo Genes that share pathways with MYL6B: view

Interacting Proteins for MYL6B Gene

SIGNOR curated interactions for MYL6B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MYL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 2304459
GO:0007519 skeletal muscle tissue development TAS 2304459
GO:0030049 muscle filament sliding TAS 2304459
genes like me logo Genes that share ontologies with MYL6B: view

Drugs & Compounds for MYL6B Gene

(2) Drugs for MYL6B Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID Experimental Pharma Target 0
calcium Nutra 0
genes like me logo Genes that share compounds with MYL6B: view

Transcripts for MYL6B Gene

Unigene Clusters for MYL6B Gene

Myosin, light chain 6B, alkali, smooth muscle and non-muscle:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MYL6B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MYL6B Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8
SP1: - - -
SP2: -
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for MYL6B Gene

GeneLoc Exon Structure for
MYL6B
ECgene alternative splicing isoforms for
MYL6B

Expression for MYL6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYL6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYL6B Gene

This gene is overexpressed in Muscle - Skeletal (x9.1).

Protein differential expression in normal tissues from HIPED for MYL6B Gene

This gene is overexpressed in Neutrophil (12.6), Nasal epithelium (8.3), Blymphocyte (7.8), Esophagus (6.5), and Cervix (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYL6B Gene



NURSA nuclear receptor signaling pathways regulating expression of MYL6B Gene:

MYL6B

SOURCE GeneReport for Unigene cluster for MYL6B Gene:

Hs.632731

Evidence on tissue expression from TISSUES for MYL6B Gene

  • Muscle(4.4)
  • Nervous system(4.4)
  • Blood(2)
genes like me logo Genes that share expression patterns with MYL6B: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYL6B Gene

Orthologs for MYL6B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYL6B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYL6B 33 34
  • 99.52 (n)
mouse
(Mus musculus)
Mammalia Myl6b 33 16 34
  • 88.57 (n)
dog
(Canis familiaris)
Mammalia MYL6B 33 34
  • 86.22 (n)
rat
(Rattus norvegicus)
Mammalia RGD1560334 33
  • 86.15 (n)
cow
(Bos Taurus)
Mammalia MYL6B 33 34
  • 84.78 (n)
lizard
(Anolis carolinensis)
Reptilia MYL6B 34
  • 74 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii myl6 34
  • 66 (a)
ManyToMany
zgc:153867 34
  • 61 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Mlc-c 34
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mlc-5 34
  • 47 (a)
ManyToMany
mlc-6 34
  • 45 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MLC1 34
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.211 34
  • 53 (a)
ManyToMany
CSA.4806 34
  • 44 (a)
ManyToMany
CSA.6288 34
  • 44 (a)
ManyToMany
CSA.6678 34
  • 44 (a)
ManyToMany
Species where no ortholog for MYL6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MYL6B Gene

ENSEMBL:
Gene Tree for MYL6B (if available)
TreeFam:
Gene Tree for MYL6B (if available)

Paralogs for MYL6B Gene

Paralogs for MYL6B Gene

(11) SIMAP similar genes for MYL6B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for MYL6B Gene

genes like me logo Genes that share paralogs with MYL6B: view

Variants for MYL6B Gene

Sequence variations from dbSNP and Humsavar for MYL6B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000265933 -- 56,156,421(+) CCAAC(A/G)TGGTG intron-variant, upstream-variant-2KB
rs1000893926 -- 56,151,448(+) TTTTA(A/C)AGATG upstream-variant-2KB, utr-variant-5-prime
rs1001177739 -- 56,156,252(+) AGTGA(A/G)CCGAG intron-variant
rs1001371958 -- 56,154,167(+) AGGGG(C/G)TATCT intron-variant, downstream-variant-500B
rs1001775884 -- 56,156,048(+) CGCCT(A/G)TAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYL6B Gene

Variant ID Type Subtype PubMed ID
dgv2648n54 CNV loss 21841781
nsv1051961 CNV gain 25217958
nsv559013 CNV loss 21841781

Variation tolerance for MYL6B Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYL6B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYL6B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYL6B Gene

Disorders for MYL6B Gene

Relevant External Links for MYL6B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYL6B

No disorders were found for MYL6B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYL6B Gene

Publications for MYL6B Gene

  1. Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. (PMID: 2304459) Hailstones DL … Gunning PW (Molecular and cellular biology 1990) 2 3 4 22 60
  2. A novel isoform of myosin alkali light chain isolated from human muscle cells. (PMID: 2602161) Zimmermann K … Starzinski-Powitz A (Nucleic acids research 1989) 2 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60

Products for MYL6B Gene

Sources for MYL6B Gene

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