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Aliases for MYL6B Gene

Aliases for MYL6B Gene

  • Myosin, Light Chain 6B, Alkali, Smooth Muscle And Non-Muscle 2 3
  • MLC1SA 3 4 6
  • Myosin, Light Polypeptide 6B, Alkali, Smooth Muscle And Non-Muscle 2 3
  • Smooth Muscle And Nonmuscle Myosin Light Chain Alkali 6B 3 4
  • Myosin Light Chain 1 Slow-Twitch Muscle A Isoform 3 4
  • Myosin Light Chain 1 Slow A 2 3
  • Smooth Muscle And Non-Muscle Myosin Alkali Light Chain 6B 3
  • Myosin Light Chain 1, Slow-Twitch Muscle A Isoform 3
  • Myosin Alkali Light Chain 1 Slow A 3
  • Myosin Light Chain 6B 3

External Ids for MYL6B Gene

Summaries for MYL6B Gene

Entrez Gene Summary for MYL6B Gene

  • Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

GeneCards Summary for MYL6B Gene

MYL6B (Myosin, Light Chain 6B, Alkali, Smooth Muscle And Non-Muscle) is a Protein Coding gene. Among its related pathways are Immune response CCR3 signaling in eosinophils and Oxytocin signaling pathway. GO annotations related to this gene include calcium ion binding and motor activity. An important paralog of this gene is MYL1.

UniProtKB/Swiss-Prot for MYL6B Gene

  • Regulatory light chain of myosin. Does not bind calcium

Gene Wiki entry for MYL6B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL6B Gene

Genomics for MYL6B Gene

Genomic Location for MYL6B Gene

56,152,256 bp from pter
56,159,647 bp from pter
7,392 bases
Plus strand

Genomic View for MYL6B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYL6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL6B Gene

Regulatory Elements for MYL6B Gene

Proteins for MYL6B Gene

  • Protein details for MYL6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myosin light chain 6B
    Protein Accession:
    Secondary Accessions:

    Protein attributes for MYL6B Gene

    208 amino acids
    Molecular mass:
    22764 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains

    Three dimensional structures from OCA and Proteopedia for MYL6B Gene

neXtProt entry for MYL6B Gene

Proteomics data for MYL6B Gene at MOPED

Post-translational modifications for MYL6B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys107

Other Protein References for MYL6B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MYL6B Gene

Domains for MYL6B Gene

Gene Families for MYL6B Gene

  • EFHAND :EF-hand domain containing
  • MYL :Myosins / Light chain

Protein Domains for MYL6B Gene



  • Contains 3 EF-hand domains.:
    • P14649
genes like me logo Genes that share domains with MYL6B: view

Function for MYL6B Gene

Molecular function for MYL6B Gene

UniProtKB/Swiss-Prot Function: Regulatory light chain of myosin. Does not bind calcium

Gene Ontology (GO) - Molecular Function for MYL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity TAS 2304459
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 15510214
GO:0008307 structural constituent of muscle TAS 2304459
genes like me logo Genes that share ontologies with MYL6B: view

Phenotypes for MYL6B Gene

GenomeRNAi human phenotypes for MYL6B:
genes like me logo Genes that share phenotypes with MYL6B: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MYL6B Gene

Localization for MYL6B Gene

Subcellular locations from

Jensen Localization Image for MYL6B Gene COMPARTMENTS Subcellular localization image for MYL6B gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MYL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005859 muscle myosin complex TAS 2458299
GO:0016459 myosin complex TAS 2304459
GO:0016461 unconventional myosin complex TAS 2304459
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with MYL6B: view

Pathways for MYL6B Gene

genes like me logo Genes that share pathways with MYL6B: view

Interacting Proteins for MYL6B Gene

Gene Ontology (GO) - Biological Process for MYL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 2304459
GO:0007519 skeletal muscle tissue development TAS 2304459
GO:0008152 metabolic process TAS 2304459
GO:0030049 muscle filament sliding TAS 2304459
genes like me logo Genes that share ontologies with MYL6B: view

Compounds for MYL6B Gene

(1) HMDB Compounds for MYL6B Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(1) Drugbank Compounds for MYL6B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
genes like me logo Genes that share compounds with MYL6B: view

Transcripts for MYL6B Gene

Unigene Clusters for MYL6B Gene

Myosin, light chain 6B, alkali, smooth muscle and non-muscle:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYL6B Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8
SP1: - - -
SP2: -
SP4: -

Relevant External Links for MYL6B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYL6B Gene

mRNA expression in normal human tissues for MYL6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYL6B Gene

This gene is overexpressed in Muscle - Skeletal (9.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MYL6B Gene

SOURCE GeneReport for Unigene cluster for MYL6B Gene Hs.632731

genes like me logo Genes that share expressions with MYL6B: view

Orthologs for MYL6B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYL6B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MYL6B 36
  • 99.52 (n)
  • 99.52 (a)
MYL6B 37
  • 100 (a)
(Bos Taurus)
Mammalia MYL6B 36
  • 84.78 (n)
  • 79.81 (a)
MYL6B 37
  • 81 (a)
(Canis familiaris)
Mammalia MYL6B 36
  • 86.22 (n)
  • 87.5 (a)
MYL6B 37
  • 94 (a)
(Mus musculus)
Mammalia Myl6b 36
  • 88.57 (n)
  • 89.86 (a)
Myl6b 16
Myl6b 37
  • 92 (a)
(Rattus norvegicus)
Mammalia RGD1560334 36
  • 86.15 (n)
  • 85.02 (a)
(Anolis carolinensis)
Reptilia MYL6B 37
  • 74 (a)
(Danio rerio)
Actinopterygii myl6 37
  • 66 (a)
zgc:153867 37
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mlc-c 37
  • 52 (a)
(Caenorhabditis elegans)
Secernentea mlc-5 37
  • 47 (a)
mlc-6 37
  • 45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MLC1 37
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.211 37
  • 53 (a)
CSA.4806 37
  • 44 (a)
CSA.6288 37
  • 44 (a)
CSA.6678 37
  • 44 (a)
Species with no ortholog for MYL6B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MYL6B Gene

Gene Tree for MYL6B (if available)
Gene Tree for MYL6B (if available)

Paralogs for MYL6B Gene

Paralogs for MYL6B Gene

Selected SIMAP similar genes for MYL6B Gene using alignment to 3 proteins: Pseudogenes for MYL6B Gene

genes like me logo Genes that share paralogs with MYL6B: view

Variants for MYL6B Gene

Sequence variations from dbSNP and Humsavar for MYL6B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs3070174 -- 56,152,711(+) TGTGT(-/GTGT/GTGTGT/GTGTGTGT)CGTGT intron-variant
rs3759096 -- 56,153,026(-) TGGGC(C/G)CTCCT intron-variant
rs3809134 -- 56,152,227(+) GCTGC(A/G)GCCTC upstream-variant-2KB
rs7957318 -- 56,151,255(+) ttttg(G/T)atttt upstream-variant-2KB
rs11556402 -- 56,155,439(+) GTGTG(A/G)ACTTT missense, reference

Relevant External Links for MYL6B Gene

HapMap Linkage Disequilibrium report

No data available for Structural Variations from Database of Genomic Variants (DGV) for MYL6B Gene

Disorders for MYL6B Gene

No disorders were found for MYL6B Gene.

No data available for UniProtKB/Swiss-Prot for MYL6B Gene

Publications for MYL6B Gene

  1. Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. (PMID: 2304459) Hailstones D.L. … Gunning P.W. (Mol. Cell. Biol. 1990) 2 3 4 23
  2. A novel isoform of myosin alkali light chain isolated from human muscle cells. (PMID: 2602161) Zimmermann K. … Starzinski-Powitz A. (Nucleic Acids Res. 1989) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Three myosin V structures delineate essential features of chemo-mechanical transduction. (PMID: 15510214) Coureux P.D. … Houdusse A. (EMBO J. 2004) 3
  5. IQ motif selectivity in human IQGAP1: binding of myosin essential light chain and S100B. (PMID: 18587628) Pathmanathan S. … Timson D.J. (Mol. Cell. Biochem. 2008) 3

Products for MYL6B Gene

Sources for MYL6B Gene

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