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Aliases for MYL6 Gene

Aliases for MYL6 Gene

  • Myosin Light Chain 6 2 3 5
  • Myosin, Light Polypeptide 6, Alkali, Smooth Muscle And Non-Muscle 2 3
  • Myosin, Light Chain 6, Alkali, Smooth Muscle And Non-Muscle 2 3
  • Myosin Light Chain Alkali 3 3 4
  • 17 KDa Myosin Light Chain 3 4
  • Myosin Light Chain A3 3 4
  • MLC-3 3 4
  • LC17 3 4
  • Smooth Muscle And Nonmuscle Myosin Light Chain Alkali 6 4
  • Myosin Light Polypeptide 6 3
  • Myosin Light Chain 3 4
  • LC17-GI 3
  • LC17-NM 3
  • MLC1SM 3
  • MLC3NM 3
  • MLC3SM 3
  • ESMLC 3
  • LC17A 3
  • LC17B 3

External Ids for MYL6 Gene

Previous GeneCards Identifiers for MYL6 Gene

  • GC12P056485
  • GC12M056741
  • GC12P056263
  • GC12P054832
  • GC12P054834
  • GC12P054838
  • GC12P056552
  • GC12P053591
  • GC12P056554

Summaries for MYL6 Gene

Entrez Gene Summary for MYL6 Gene

  • Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYL6 Gene

MYL6 (Myosin Light Chain 6) is a Protein Coding gene. Diseases associated with MYL6 include Fish Allergy. Among its related pathways are Semaphorin interactions and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include calcium ion binding and structural constituent of muscle. An important paralog of this gene is MYL6B.

UniProtKB/Swiss-Prot for MYL6 Gene

  • Regulatory light chain of myosin. Does not bind calcium.

Tocris Summary for MYL6 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.

Gene Wiki entry for MYL6 Gene

Additional gene information for MYL6 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL6 Gene

Genomics for MYL6 Gene

Regulatory Elements for MYL6 Gene

Enhancers for MYL6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H056124 1.4 ENCODE dbSUPER 25.4 -30.2 -30166 6 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 ZNF610 NEMP1 BAZ2A SMARCC2 DNAJC14 MYL6 PYM1 ENSG00000258199 RN7SL809P ZBTB39 ZC3H10
GH12H056156 1.4 ENCODE dbSUPER 13 +1.8 1774 6 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 NFYC ZFP41 MEF2D SSRP1 ZNF610 NEMP1 BAZ2A ZC3H10 DNAJC14 TMEM198B SMARCC2 RN7SL809P ENSG00000257740 ENSG00000258199 PYM1
GH12H057109 1.5 ENCODE dbSUPER 11.8 +953.1 953093 3 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 MCM3 MEF2D SSRP1 NEMP1 BAZ2A EEF1AKMT3 ENSG00000257740 SMARCC2 CDK4 CTDSP2 PAN2 ANKRD52 DTX3
GH12H056298 1.4 ENCODE dbSUPER 12.4 +142.7 142650 4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 BAZ2A ZC3H10 NEMP1 RN7SL809P CDK2 DNAJC14 RPL41 MMP19 ENSG00000257303 TMEM198B
GH12H056114 1.5 ENCODE dbSUPER 11.5 -39.8 -39838 6 MLX ZFP64 DMAP1 YBX1 YY1 ZNF143 SP3 NFYC MEF2D SSRP1 BAZ2A NEMP1 DNAJC14 ZC3H10 RN7SL809P ENSG00000258317 ANKRD52 SMARCC2 RNU6-343P PYM1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYL6 on UCSC Golden Path with GeneCards custom track

Promoters for MYL6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052485 239 2401 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 NFYC ZFP41 MEF2D SSRP1 ZNF610

Genomic Location for MYL6 Gene

Chromosome:
12
Start:
56,158,161 bp from pter
End:
56,163,496 bp from pter
Size:
5,336 bases
Orientation:
Plus strand

Genomic View for MYL6 Gene

Genes around MYL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL6 Gene

Proteins for MYL6 Gene

  • Protein details for MYL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60660-MYL6_HUMAN
    Recommended name:
    Myosin light polypeptide 6
    Protein Accession:
    P60660
    Secondary Accessions:
    • P16475
    • P24572
    • P24573
    • Q12790
    • Q561V9
    • Q6IAZ0
    • Q6IPY5

    Protein attributes for MYL6 Gene

    Size:
    151 amino acids
    Molecular mass:
    16930 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains. Interacts with SPATA6.

    Alternative splice isoforms for MYL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYL6 Gene

Post-translational modifications for MYL6 Gene

  • Ubiquitination at Lys63
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MYL6 Gene

Domains & Families for MYL6 Gene

Gene Families for MYL6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MYL6 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYL6: view

No data available for UniProtKB/Swiss-Prot for MYL6 Gene

Function for MYL6 Gene

Molecular function for MYL6 Gene

UniProtKB/Swiss-Prot Function:
Regulatory light chain of myosin. Does not bind calcium.

Phenotypes From GWAS Catalog for MYL6 Gene

Gene Ontology (GO) - Molecular Function for MYL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity TAS 2304459
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 14743216
GO:0008307 structural constituent of muscle IDA 16953301
GO:0030898 actin-dependent ATPase activity ISS --
genes like me logo Genes that share ontologies with MYL6: view
genes like me logo Genes that share phenotypes with MYL6: view

Animal Model Products

CRISPR Products

miRNA for MYL6 Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MYL6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYL6 Gene

Localization for MYL6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYL6 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for MYL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005903 brush border IDA 22114352
GO:0016020 membrane IDA 19946888
GO:0016459 myosin complex TAS 2304459
GO:0016461 unconventional myosin complex TAS 2304459
genes like me logo Genes that share ontologies with MYL6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MYL6 Gene

Pathways & Interactions for MYL6 Gene

genes like me logo Genes that share pathways with MYL6: view

Gene Ontology (GO) - Biological Process for MYL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 2304459
GO:0007519 skeletal muscle tissue development TAS 2304459
GO:0030049 muscle filament sliding TAS 2304459
genes like me logo Genes that share ontologies with MYL6: view

No data available for SIGNOR curated interactions for MYL6 Gene

Drugs & Compounds for MYL6 Gene

(3) Drugs for MYL6 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
(R)-(+)-Blebbistatin Pharma non-muscle myosin II ATPases inhibitor, cell-permeable, Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 0
BTS Pharma Selective inhibitor of skeletal muscle myosin II ATPase activity 0

(2) Additional Compounds for MYL6 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-Blebbistatin
674289-55-5
(S)-(-)-Blebbistatin
856925-71-8

(4) Tocris Compounds for MYL6 Gene

Compound Action Cas Number
(+-)-Blebbistatin Selective inhibitor of myosin II ATPase activity 674289-55-5
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 1177356-70-5
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760) 856925-71-8
BTS Selective inhibitor of skeletal muscle myosin II ATPase activity 1576-37-0
genes like me logo Genes that share compounds with MYL6: view

Transcripts for MYL6 Gene

Unigene Clusters for MYL6 Gene

Myosin, light chain 6, alkali, smooth muscle and non-muscle:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MYL6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MYL6 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c
SP1: - -
SP2: - - - - - - - -
SP3: - -
SP4: - - - - -
SP5: - - - - - -
SP6: -
SP7: - - - -
SP8:
SP9: -
SP10: -

Relevant External Links for MYL6 Gene

GeneLoc Exon Structure for
MYL6
ECgene alternative splicing isoforms for
MYL6

Expression for MYL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MYL6 Gene

This gene is overexpressed in Colon muscle (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYL6 Gene



Protein tissue co-expression partners for MYL6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MYL6 Gene:

MYL6

SOURCE GeneReport for Unigene cluster for MYL6 Gene:

Hs.632717

Evidence on tissue expression from TISSUES for MYL6 Gene

  • Lung(5)
  • Eye(4.9)
  • Intestine(4.9)
  • Liver(4.9)
  • Pancreas(4.9)
  • Nervous system(4.9)
  • Blood(4.1)
  • Skin(4)
  • Bone(3.7)
  • Muscle(3.6)
  • Heart(3)
  • Kidney(2.8)
  • Adrenal gland(2.7)
  • Bone marrow(2.7)
  • Gall bladder(2.7)
  • Lymph node(2.6)
  • Spleen(2.6)
  • Stomach(2.6)
  • Thyroid gland(2.6)
genes like me logo Genes that share expression patterns with MYL6: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYL6 Gene

Orthologs for MYL6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYL6 33 34
  • 96.69 (n)
mouse
(Mus musculus)
Mammalia Myl6 16 34 33
  • 95.58 (n)
dog
(Canis familiaris)
Mammalia MYL6 33
  • 95.14 (n)
rat
(Rattus norvegicus)
Mammalia Myl6 33
  • 93.6 (n)
cow
(Bos Taurus)
Mammalia MYL6 34 33
  • 91.61 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYL6 34
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myl6 33
  • 72.19 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5516 33
zebrafish
(Danio rerio)
Actinopterygii zgc:153867 34 33
  • 77.48 (n)
ManyToMany
myl6 34
  • 73 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.55 33
fruit fly
(Drosophila melanogaster)
Insecta Mlc-c 35 33 34
  • 59.64 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007806 33
  • 57.53 (n)
worm
(Caenorhabditis elegans)
Secernentea mlc-5 33 34
  • 54.61 (n)
T12D8.6 35
  • 47 (a)
mlc-6 34
  • 44 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MLC1 34
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.211 34
  • 54 (a)
ManyToMany
CSA.4806 34
  • 46 (a)
ManyToMany
CSA.6288 34
  • 46 (a)
ManyToMany
CSA.6678 34
  • 45 (a)
ManyToMany
Species where no ortholog for MYL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYL6 Gene

ENSEMBL:
Gene Tree for MYL6 (if available)
TreeFam:
Gene Tree for MYL6 (if available)

Paralogs for MYL6 Gene

Variants for MYL6 Gene

Sequence variations from dbSNP and Humsavar for MYL6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000074946 -- 56,159,333(+) GGAGA(C/T)TGGCA intron-variant
rs1000265933 -- 56,156,421(+) CCAAC(A/G)TGGTG intron-variant, upstream-variant-2KB
rs1001165798 -- 56,160,690(+) AGCCT(C/T)TCCTC intron-variant
rs1001492387 -- 56,160,547(+) AATGG(A/C)ATGTC intron-variant
rs1001728908 -- 56,161,631(+) GATGG(C/T)GATGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MYL6 Gene

Variant ID Type Subtype PubMed ID
dgv2648n54 CNV loss 21841781
nsv1051961 CNV gain 25217958
nsv559013 CNV loss 21841781

Variation tolerance for MYL6 Gene

Residual Variation Intolerance Score: 55.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYL6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYL6 Gene

Disorders for MYL6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYL6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fish allergy
  • allergy to fish
- elite association - COSMIC cancer census association via MalaCards
Search MYL6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYL6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYL6
genes like me logo Genes that share disorders with MYL6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYL6 Gene

Publications for MYL6 Gene

  1. Molecular cloning, sequencing, and characterization of smooth muscle myosin alkali light chain from human eye cDNA: homology with myocardial fatty acid ethyl ester synthase-III cDNA. (PMID: 8188229) Bora PS … Lange LG (Genomics 1994) 2 3 4 60
  2. Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. (PMID: 2304459) Hailstones DL … Gunning PW (Molecular and cellular biology 1990) 2 3 4 60
  3. The alkali light chains of human smooth and nonmuscle myosins are encoded by a single gene. Tissue-specific expression by alternative splicing pathways. (PMID: 2722814) Lenz S … Arnold HH (The Journal of biological chemistry 1989) 2 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Molecular cloning and sequencing of myosin light chains in human megakaryoblastic leukemia cells. (PMID: 11436981) Watanabe M … Higashihara M (Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 2001) 3 4 60

Products for MYL6 Gene

Sources for MYL6 Gene

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