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Aliases for MYL6 Gene

Aliases for MYL6 Gene

  • Myosin Light Chain 6 2 3 5
  • Myosin, Light Polypeptide 6, Alkali, Smooth Muscle And Non-Muscle 2 3
  • Myosin, Light Chain 6, Alkali, Smooth Muscle And Non-Muscle 2 3
  • Myosin Light Chain Alkali 3 3 4
  • 17 KDa Myosin Light Chain 3 4
  • Myosin Light Chain A3 3 4
  • MLC-3 3 4
  • LC17 3 4
  • Smooth Muscle And Nonmuscle Myosin Light Chain Alkali 6 4
  • Myosin Light Chain 3 4
  • LC17-GI 3
  • LC17-NM 3
  • MLC1SM 3
  • MLC3NM 3
  • MLC3SM 3
  • ESMLC 3
  • LC17A 3
  • LC17B 3

External Ids for MYL6 Gene

Previous GeneCards Identifiers for MYL6 Gene

  • GC12P056485
  • GC12M056741
  • GC12P056263
  • GC12P054832
  • GC12P054834
  • GC12P054838
  • GC12P056552
  • GC12P053591
  • GC12P056554

Summaries for MYL6 Gene

Entrez Gene Summary for MYL6 Gene

  • Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYL6 Gene

MYL6 (Myosin Light Chain 6) is a Protein Coding gene. Diseases associated with MYL6 include Lynch Syndrome. Among its related pathways are ERK Signaling and Semaphorin interactions. GO annotations related to this gene include calcium ion binding and structural constituent of muscle. An important paralog of this gene is MYL3.

UniProtKB/Swiss-Prot for MYL6 Gene

  • Regulatory light chain of myosin. Does not bind calcium.

Tocris Summary for MYL6 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.

Gene Wiki entry for MYL6 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL6 Gene

Genomics for MYL6 Gene

Regulatory Elements for MYL6 Gene

Enhancers for MYL6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MYL6 on UCSC Golden Path with GeneCards custom track

Promoters for MYL6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MYL6 on UCSC Golden Path with GeneCards custom track

Genomic Location for MYL6 Gene

Chromosome:
12
Start:
56,158,161 bp from pter
End:
56,163,496 bp from pter
Size:
5,336 bases
Orientation:
Plus strand

Genomic View for MYL6 Gene

Genes around MYL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL6 Gene

Proteins for MYL6 Gene

  • Protein details for MYL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60660-MYL6_HUMAN
    Recommended name:
    Myosin light polypeptide 6
    Protein Accession:
    P60660
    Secondary Accessions:
    • P16475
    • P24572
    • P24573
    • Q12790
    • Q561V9
    • Q6IAZ0
    • Q6IPY5

    Protein attributes for MYL6 Gene

    Size:
    151 amino acids
    Molecular mass:
    16930 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains. Interacts with SPATA6.

    Alternative splice isoforms for MYL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYL6 Gene

Proteomics data for MYL6 Gene at MOPED

Post-translational modifications for MYL6 Gene

  • Ubiquitination at Lys 63
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for MYL6 Gene

Domains & Families for MYL6 Gene

Protein Domains for MYL6 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P60660

UniProtKB/Swiss-Prot:

MYL6_HUMAN :
  • Contains 3 EF-hand domains.
Domain:
  • Contains 3 EF-hand domains.
genes like me logo Genes that share domains with MYL6: view

Function for MYL6 Gene

Molecular function for MYL6 Gene

UniProtKB/Swiss-Prot Function:
Regulatory light chain of myosin. Does not bind calcium.
genes like me logo Genes that share phenotypes with MYL6: view

Animal Model Products

miRNA for MYL6 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYL6 Gene

Localization for MYL6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYL6 Gene COMPARTMENTS Subcellular localization image for MYL6 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for MYL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with MYL6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYL6 Gene

Pathways & Interactions for MYL6 Gene

genes like me logo Genes that share pathways with MYL6: view

Gene Ontology (GO) - Biological Process for MYL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 2304459
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with MYL6: view

No data available for SIGNOR curated interactions for MYL6 Gene

Drugs & Compounds for MYL6 Gene

(1) Drugs for MYL6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(5) Additional Compounds for MYL6 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-Blebbistatin
674289-55-5
(R)-(+)-Blebbistatin
1177356-70-5
(S)-(-)-Blebbistatin
856925-71-8
ML 9 hydrochloride
105637-50-1
W-7 hydrochloride
61714-27-0

(5) Tocris Compounds for MYL6 Gene

Compound Action Cas Number
(+-)-Blebbistatin Selective inhibitor of myosin II ATPase activity 674289-55-5
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 1177356-70-5
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760) 856925-71-8
ML 9 hydrochloride Myosin light chain kinase inhibitor 105637-50-1
W-7 hydrochloride Calmodulin antagonist. Inhibits myosin light chain kinase 61714-27-0
genes like me logo Genes that share compounds with MYL6: view

Transcripts for MYL6 Gene

Unigene Clusters for MYL6 Gene

Myosin, light chain 6, alkali, smooth muscle and non-muscle:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYL6 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c
SP1: - -
SP2: - - - - - - - -
SP3: - -
SP4: - - - - -
SP5: - - - - - -
SP6: -
SP7: - - - -
SP8:
SP9: -
SP10: -

Relevant External Links for MYL6 Gene

GeneLoc Exon Structure for
MYL6
ECgene alternative splicing isoforms for
MYL6

Expression for MYL6 Gene

mRNA expression in normal human tissues for MYL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MYL6 Gene

This gene is overexpressed in Colon muscle (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYL6 Gene



SOURCE GeneReport for Unigene cluster for MYL6 Gene Hs.632717

genes like me logo Genes that share expression patterns with MYL6: view

Protein tissue co-expression partners for MYL6 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MYL6 Gene

Orthologs for MYL6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYL6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYL6 35
  • 91.61 (n)
  • 96.69 (a)
MYL6 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYL6 35
  • 95.14 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Myl6 35
  • 95.58 (n)
  • 100 (a)
Myl6 16
Myl6 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYL6 35
  • 96.69 (n)
  • 96.69 (a)
MYL6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myl6 35
  • 93.6 (n)
  • 100 (a)
lizard
(Anolis carolinensis)
Reptilia MYL6 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myl6 35
  • 72.19 (n)
  • 74.83 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5516 35
zebrafish
(Danio rerio)
Actinopterygii zgc:153867 35
  • 77.48 (n)
  • 84.11 (a)
myl6 36
  • 73 (a)
ManyToMany
zgc:153867 36
  • 55 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.55 35
fruit fly
(Drosophila melanogaster)
Insecta Mlc-c 37
  • 53 (a)
Mlc-c 35
  • 59.64 (n)
  • 55.78 (a)
Mlc-c 36
  • 49 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007806 35
  • 57.53 (n)
  • 52.74 (a)
worm
(Caenorhabditis elegans)
Secernentea T12D8.6 37
  • 47 (a)
mlc-5 35
  • 54.61 (n)
  • 48.94 (a)
mlc-5 36
  • 48 (a)
ManyToMany
mlc-6 36
  • 44 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MLC1 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.211 36
  • 54 (a)
ManyToMany
CSA.4806 36
  • 46 (a)
ManyToMany
CSA.6288 36
  • 46 (a)
ManyToMany
CSA.6678 36
  • 45 (a)
ManyToMany
Species with no ortholog for MYL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYL6 Gene

ENSEMBL:
Gene Tree for MYL6 (if available)
TreeFam:
Gene Tree for MYL6 (if available)

Paralogs for MYL6 Gene

Paralogs for MYL6 Gene

genes like me logo Genes that share paralogs with MYL6: view

Variants for MYL6 Gene

Sequence variations from dbSNP and Humsavar for MYL6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1050470 - 56,160,106(+) ATGGC(A/C)CCGTC reference, missense
rs11553509 - 56,160,053(+) GGGCA(C/T)CTATG reference, missense
rs13997 -- 56,161,334(-) GGTAC(C/G)CCAAG intron-variant
rs17097849 -- 56,158,583(+) ACAGG(-/AGTTTGTGGGTCA)GAGTT intron-variant
rs17118333 -- 56,159,042(+) CTTCT(G/T)CCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYL6 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV Complex 15286789

Variation tolerance for MYL6 Gene

Residual Variation Intolerance Score: 55.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MYL6 Gene

Disorders for MYL6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYL6 Gene - From: GeneCards

Disorder Aliases PubMed IDs
lynch syndrome
  • colorectal cancer, hereditary nonpolyposis, type 1
- elite association - COSMIC cancer census association via MalaCards
Search MYL6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYL6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYL6
genes like me logo Genes that share disorders with MYL6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYL6 Gene

Publications for MYL6 Gene

  1. Molecular cloning, sequencing, and characterization of smooth muscle myosin alkali light chain from human eye cDNA: homology with myocardial fatty acid ethyl ester synthase-III cDNA. (PMID: 8188229) Bora P.S. … Lange L.G. (Genomics 1994) 2 3 4 67
  2. Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. (PMID: 2304459) Hailstones D.L. … Gunning P.W. (Mol. Cell. Biol. 1990) 2 3
  3. The alkali light chains of human smooth and nonmuscle myosins are encoded by a single gene. Tissue-specific expression by alternative splicing pathways. (PMID: 2722814) Lenz S. … Arnold H.H. (J. Biol. Chem. 1989) 2 3
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for MYL6 Gene

Sources for MYL6 Gene

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