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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MYL6 Gene

protein-coding GIFtS: 62
GCID: GC12P056552

myosin, light chain 6, alkali, smooth muscle and non-muscle

(Previous names: myosin, light polypeptide 6, alkali, smooth muscle and...)

Explore 9 diseases affiliated with
MYL6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Myosin, Light Chain 6, Alkali, Smooth Muscle And Non-Muscle¹ ²		MLC-3² ³
ESMLC¹ ²		LC17-GI²
MLC1SM¹ ²		LC17-NM²
MLC3NM¹ ²		LC17A²
Myosin, Light Polypeptide 6, Alkali, Smooth Muscle And Non-Muscle¹ ²		LC17B²
Myosin Light Chain A3² ³		MLC3SM²
Myosin Light Chain Alkali 3² ³		Myosin Light Polypeptide 6²
17 KDa Myosin Light Chain² ³		Myosin Light Chain 3³
LC17² ³		Smooth Muscle And Nonmuscle Myosin Light Chain Alkali 6³

External Ids:	HGNC: 7587¹	Entrez Gene: 4637²	Ensembl: ENSG00000092841⁷	OMIM: 609931⁵	UniProtKB: P60660³

Export aliases for MYL6 gene to outside databases

Previous GC identifers: GC12P056485 GC12M056741 GC12P056263 GC12P054832 GC12P054834 GC12P054838 GC12P053591

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYL6:

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali

light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is

expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been

described and two transcript variants encoding different isoforms have been identified for this gene. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MYL6_HUMAN, P60660

Function: Regulatory light chain of myosin. Does not bind calcium

summary for MYL6:

Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding

and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),

almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain

that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts

with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory

myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.

Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is

involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a

contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by

intracellular Ca2+ concentrations.

Gene Wiki entry for MYL6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MYL6 gene promoter:
SRF SRF (504 AA) HSF1 (long) CUTL1 MIF-1 Tal-1beta AREB6 HEN1 HSF1short ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MYL6 promoter sequence

Search SABiosciences Chromatin IP Primers for MYL6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYL6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2 Ensembl cytogenetic band: 12q13.2 HGNC cytogenetic band: 12q13.13

MYL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL6 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P056552: view genomic region (about GC identifiers)

Start:	56,551,945 bp from pter	End:	56,557,280 bp from pter
Size:	5,336 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MYL6_HUMAN, P60660 (See protein sequence)

Recommended Name: Myosin light polypeptide 6

Size: 151 amino acids; 16930 Da

Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains

Secondary accessions: P16475 P24572 P24573 Q12790 Q561V9 Q6IAZ0 Q6IPY5

Alternative splicing: 2 isoforms: P60660-1, P16475-1 P60660-2, P24572-2 (Contains a phosphoserine at position 135)

Explore the universe of human proteins at neXtProt for MYL6: NX_P60660

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P60660

MYL6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_066299.2 NP_524147.2

ENSEMBL proteins:

ENSP00000446955 ENSP00000446640 ENSP00000293422 ENSP00000301540 ENSP00000449086

ENSP00000446709 ENSP00000441750 ENSP00000446714 ENSP00000446721 ENSP00000446687

ENSP00000446627 ENSP00000450116 ENSP00000448859 ENSP00000448101 ENSP00000448457

Reactome Protein details: P60660
Human Recombinant Protein Products:

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	Novus Biologicals MYL6 Proteins Novus Biologicals MYL6 Lysates
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	ProSpec Recombinant Protein for MYL6
	Uscn Proteins for MYL6

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0016459	myosin complex	TAS	2304459
GO:0016461	unconventional myosin complex	TAS	2304459

MYL6 for ontologies About GeneDecksing

MYL6 Antibody Products:

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	Uscn Antibodies for MYL6
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	Uscn ELISAs and CLIAs for MYL6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MYL6 for domains About GeneDecksing

2 InterPro domains/families:

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

Graphical View of Domain Structure for InterPro Entry P60660

ProtoNet protein and cluster: P60660

UniProtKB/Swiss-Prot: MYL6_HUMAN, P60660

Similarity: Contains 3 EF-hand domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MYL6_HUMAN, P60660

Function: Regulatory light chain of myosin. Does not bind calcium

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MYL6 Browse MicroRNA Expression Plasmids
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL6

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003774	motor activity	TAS	2304459
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	--
GO:0008307	structural constituent of muscle	IDA	16953301
GO:0030898	actin-dependent ATPase activity	ISS	--

MYL6 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MYL6:

Decreased focal adhesion (FA)

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_Integrin-mediated cell adhesion and migration

	Cell adhesion_Integrin-mediated cell adhesion and migration	1.00			Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases	0.49
	Cell adhesion Integrin-mediated cell adhesion and migration	1.00			Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases	0.49

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

Immune response _CCR3 signaling in eosinophils

	Immune response _CCR3 signaling in eosinophils	1.00			Inhibitory action of Lipoxins on neutrophil migration	0.51
	Immune response CCR3 signaling in eosinophils	1.00

PAK Pathway

	PAK Pathway	1.00			Epithelial Adherens Junctions	0.36
	Antioxidant Action of Vitamin-C	0.56

Sema4D in semaphorin signaling

	Sema4D in semaphorin signaling	1.00			Semaphorin interactions	0.44
	Sema4D induced cell migration and growth-cone collapse	0.83

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 EMD Millipore Pathways for MYL6 (see all 7)

	Cell adhesion Integrin-mediated cell adhesion and migration
	Cell adhesion Tight junctions
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
	Immune response CCR3 signaling in eosinophils

5/16 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYL6 (see all 16)

	Activation of PKA through GPCR
	RhoA Pathway
	PKA Signaling
	Guidance Cues and Growth Cone Motility
	Antioxidant Action of Vitamin-C

5/8 GeneGo (Thomson Reuters) Pathways for MYL6 (see all 8)

	Signal transduction Activation of PKC via G-Protein coupled receptor
	Cell adhesion Integrin-mediated cell adhesion and migration
	Inhibitory action of Lipoxins on neutrophil migration
	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
	Immune response CCR3 signaling in eosinophils

1 BioSystems Pathway for MYL6

Focal Adhesion

5/7 Reactome Pathways for MYL6 (see all 7)

	Developmental Biology
	Sema4D induced cell migration and growth-cone collapse
	Semaphorin interactions
	Smooth Muscle Contraction
	Muscle contraction

1 Kegg Pathway (Kegg details for MYL6):

Vascular smooth muscle contraction

MYL6 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MYL6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/85 Interacting proteins for MYL6 (P60660^{1, 2, 3} ENSP00000293422⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 85)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CHUK	O15111²^,³, ENSP00000359424⁴	MINT-48059 I2D: score=2 STRING: ENSP00000359424
IKBKE	Q14164²^,³	MINT-48122 I2D: score=3
IKBKG	Q9Y6K9²^,³	MINT-48230 I2D: score=2
MAP3K3	Q99759²^,³	MINT-48505 I2D: score=2
RIPK3	Q9Y572²^,³	MINT-49150 I2D: score=2

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006936	muscle contraction	TAS	--
GO:0007411	axon guidance	TAS	--
GO:0007519	skeletal muscle tissue development	TAS	2304459
GO:0030049	muscle filament sliding	TAS	2304459

MYL6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for MYL6 available from Tocris Bioscience About this table

Compound	Action	CAS #
(R)-(+)-Blebbistatin	Selective inhibitor of myosin II. Inactive enantiomer of (�)-blebbistatin (Cat. No. 1760)	--
(S)-(-)-Blebbistatin	Selective inhibitor of myosin II. Active enantiomer of (�)-blebbistatin (Cat. No. 1760)	[856925-71-8]
(�)-Blebbistatin	Selective inhibitor of myosin II	[674289-55-5]

1 HMDB Compound for MYL6 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about MYL6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MYL6 gene (3 alternative transcripts):

NM_021019.4 NM_079423.3 NM_079425.1

Unigene Cluster for MYL6:

Myosin, light chain 6, alkali, smooth muscle and non-muscle

Hs.632717 [show with all ESTs]

Unigene Representative Sequence: BM546656

18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):

ENST00000550697(uc001sjw.2 uc001sjx.2 uc010sqe.2) ENST00000548580

ENST00000550184 ENST00000552297 ENST00000293422 ENST00000348108 ENST00000549017

ENST00000547703 ENST00000549566 ENST00000536128(uc010sqd.2) ENST00000547649

ENST00000548725 ENST00000547408 ENST00000551589 ENST00000550639 ENST00000546630

ENST00000553056 ENST00000549392

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MYL6 Browse OriGene MicroRNA Expression Plasmids
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Additional cDNA sequence:

AB046613.1 AK301198.1 BC006781.2 BC017455.1 BC071661.1 BC093066.1 CR456839.1 CR457014.1

M22918.1 M22920.1 M31212.1 U02629.1

24/108 DOTS entries (see all 108):

DT.95347289 DT.100864340 DT.91913654 DT.91959871 DT.100695392 DT.100869803 DT.95137345 DT.95137558

DT.92472009 DT.100060351 DT.95137407 DT.95137429 DT.100695397 DT.455782 DT.92472124 DT.95116117

DT.100695414 DT.100695407 DT.120745 DT.100060350 DT.95135830 DT.100695403 DT.121141248 DT.121141294

24/2991 AceView cDNA sequences (see all 2991):

BQ573922 NM_021019 CR621220 BM314372 BM798927 CA434701 AA348972 AA083851

AA331065 BM310666 BQ954593 CB112536 BG530048 CR592135 BM460660 BM769086

AV745462 BU952293 CD677912 AA384383 BQ049202 BQ417140 BE711148 BQ962498

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for MYL6 (see all 10) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	·	7c
SP1:																					-						-
SP2:							-		-		-		-								-		-		-		-
SP3:													-								-
SP4:													-								-		-		-		-
SP5:													-		-						-		-		-		-

ECgene alternative splicing isoforms for MYL6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MYL6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCTGAATG

About this image

MYL6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Endoderm-like cells (Generation of hepato...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MYL6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MYL6

SOURCE GeneReport for Unigene cluster: Hs.632717

SABiosciences Custom PCR Arrays for MYL6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYL6 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYL6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MYL6 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	MYL6⁶	--	92(a)	1 ↔ 1	2(93814871-93816568)
African clawed frog (Xenopus laevis)	Amphibia	Xl.5516²	Xenopus laevis transcribed sequence with moderate similarity more	78.21(n)		48052435
zebrafish (Danio rerio)	Actinopterygii	CB356795.1²	--	80.92(n)		CB356795.1
fruit fly (Drosophila melanogaster)	Insecta	Mlc-c^{1 , 3}	myosin ATPase³ Myosin light chain cytoplasmic¹	53(a)³ 59.64(n)¹ 55.78(a)¹		5A8³ 31474¹ NM_078494.3¹ NP_511049.1¹
worm (Caenorhabditis elegans)	Secernentea	T12D8.6³ mlc-5¹	EF hand³ Protein MLC-5¹	47(a)³ 54.76(n)¹ 49.29(a)¹		III(13694513-13695376)³ 176796¹ NM_067412.5¹ NP_499813.1¹
rice (Oryza sativa)	Liliopsida	--	OsCML9 - Calmodulin-related calcium sensor protein...	27(a)	possible ortholog	5(24067532-24068539)

ENSEMBL Gene Tree for MYL6 (if available)
TreeFam Gene Tree for MYL6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MYL6 gene

MYL4² MYL6B² MYL1² MYL3²

18/27 SIMAP similar genes for MYL6 using alignment to 14 protein entries: MYL6_HUMAN (see all proteins) (see all similar genes):

MYL1 MYL4 MYL3 MYL6B CALM2 CALM3

CALML3 CALM1 CABP5 TNNC2 CETN1 CALML5

CABP1 CETN2 TNNC1 MYL2 CALML4 MYL10

MYL6 for paralogs About GeneDecksing

5 Pseudogenes.org Pseudogenes for MYL6
PGOHUM00000238506 PGOHUM00000237502 PGOHUM00000239089 PGOHUM00000261329 PGOHUM00000261513

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs56685863^1,2	C	--	53589589(+)	`CTATTT/AAAAAA`	2	--	us2k¹		1		WA	2
rs111602323^1,2	C,	--	53589646(+)	`AGCATT/ATTGGG`	2	--	us2k¹		1		WA	2
rs113437778^1,2	C	--	53590539(+)	`TCTGCA/G/TGCCTT`	2	--	us2k¹		1		CSA	1
rs17850911^1,2	C	--	53590566(+)	`AGCGTC/TTGAGT`	2	--	us2k¹		2		NA	4
rs78564374^1,2	C,F,	--	53591318(+)	`NNNNGG/AAGAAG`	2	--	int¹		1		NA	120
rs17118333^1,2	C,F,H,	--	53591885(+)	`CTTCTG/TCCTCT`	2	--	int¹		7		MN EA NS	1006
rs74456266^1,2	F,	--	53591900(+)	`TCCTCT/CTGTGA`	2	--	int¹		1		WA	118
rs12810816^1,2	C,F,H,	--	53592019(+)	`AGCTAT/GACCCT`	2	--	int¹		20		NS EA NA WA CSA	2138
rs35436573^1,2	C,F,H,	--	53592068(+)	`AGGTTG/AGGATG`	2	--	int¹		19		NS EA NA WA CSA	2058
rs76490231^1,2		--	53592107(+)	`TCCTTA/TTAAGG`	2	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MYL6 (56551945 - 56557280 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MYL6
1 CNV: 0164

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MYL6 for disorders           About GeneDecksing

OMIM gene information: 609931    OMIM disorders: --

9 diseases for MYL6:    About MalaCards

megakaryoblastic leukemia squamous cell carcinoma rhabdomyosarcoma esophageal cancer

breast cancer esophagitis neuroblastoma leukemia

carcinoma

1 Novoseek disease relationship for MYL6 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	2	17131471 (1), 20416286 (1)

Export disorders for MYL6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MYL6 gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with MYL6)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning, sequencing, and characterization of smooth muscle myosin alkali light chain from human eye cDNA: homology with myocardial fatty acid ethyl ester synthase-III cDNA. (PubMed id 8188229)^{1, 2, 3} Bora P.S.... Lange L.G. (1994)
Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. (PubMed id 2304459)^{1, 2, 3} Hailstones D.L. and Gunning P.W. (1990)
The alkali light chains of human smooth and nonmuscle myosins are encoded by a single gene. Tissue-specific expression by alternative splicing pathways. (PubMed id 2722814)^{1, 2, 3} Lenz S....Arnold H.H. (1989)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Molecular cloning and sequencing of myosin light chains in human megakaryoblastic leukemia cells. (PubMed id 11436981)^{1, 2} Watanabe M.... Higashihara M. (2001)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)¹ Zhou J....Liang S. (2012)
An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)¹ Neganova I....Lako M. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4637	HGNC: 7587	AceView: MLC1SAandMYL6	Ensembl:ENSG00000092841	euGenes: HUgn4637
ECgene: MYL6	Kegg: 4637	H-InvDB: MYL6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MYL6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MYL6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MYL6 gene:
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GeneCards and IP:
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MYL6 Gene

myosin, light chain 6, alkali, smooth muscle and non-muscle

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MYL6 Gene

myosin, light chain 6, alkali, smooth muscle and non-muscle

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