Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MYL6 Gene

protein-coding   GIFtS: 64
GCID: GC12P056554

Myosin, Light Chain 6, Alkali, Smooth Muscle And Non-Muscle

(Previous names: myosin, light polypeptide 6, alkali, smooth muscle and non-muscle)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Myosin, Light Chain 6, Alkali, Smooth Muscle And Non-Muscle1 2     LC17-NM2
Myosin, Light Polypeptide 6, Alkali, Smooth Muscle And Non-Muscle1 2     LC17A2
Myosin Light Chain A32 3     LC17B2
Myosin Light Chain Alkali 32 3     MLC1SM2
17 KDa Myosin Light Chain2 3     MLC3NM2
LC172 3     MLC3SM2
MLC-32 3     Myosin Light Polypeptide 62
ESMLC2     Myosin Light Chain 33
LC17-GI2     Smooth Muscle And Nonmuscle Myosin Light Chain Alkali 63

External Ids:    HGNC: 75871   Entrez Gene: 46372   Ensembl: ENSG000000928417   OMIM: 6099315   UniProtKB: P606603   

Export aliases for MYL6 gene to outside databases

Previous GC identifers: GC12P056485 GC12M056741 GC12P056263 GC12P054832 GC12P054834 GC12P054838 GC12P056552 GC12P053591


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MYL6 Gene:
Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable
alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light
chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several
pseudogenes have been described and two transcript variants encoding different isoforms have been identified for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MYL6 Gene:
MYL6 (myosin, light chain 6, alkali, smooth muscle and non-muscle) is a protein-coding gene. GO annotations related to this gene include motor activity and calcium ion binding. An important paralog of this gene is MYL4.

UniProtKB/Swiss-Prot: MYL6_HUMAN, P60660
Function: Regulatory light chain of myosin. Does not bind calcium

summary for MYL6 Gene:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYL6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYL6 gene promoter:
         SRF   SRF (504 AA)   HSF1 (long)   CUTL1   MIF-1   Tal-1beta   AREB6   HEN1   HSF1short   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYL6 promoter sequence
   Search Chromatin IP Primers for MYL6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13.13

MYL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P056554:  view genomic region     (about GC identifiers)

Start:
56,551,945 bp from pter      End:
56,557,280 bp from pter
Size:
5,336 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MYL6_HUMAN, P60660 (See protein sequence)
Recommended Name: Myosin light polypeptide 6  
Size: 151 amino acids; 16930 Da
Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains
Secondary accessions: P16475 P24572 P24573 Q12790 Q561V9 Q6IAZ0 Q6IPY5
Alternative splicing: 2 isoforms:  P60660-1, P16475-1   P60660-2, P24572-2   (Contains a phosphoserine at position 135)

Explore the universe of human proteins at neXtProt for MYL6: NX_P60660

Explore proteomics data for MYL6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys26, Lys50, Lys56, Lys63, Lys81
  • Modification sites at PhosphoSitePlus

  • See MYL6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_066299.2  NP_524147.2  

    ENSEMBL proteins: 
     ENSP00000446955   ENSP00000446640   ENSP00000293422   ENSP00000301540   ENSP00000449086  
     ENSP00000446709   ENSP00000441750   ENSP00000446714   ENSP00000446721   ENSP00000446687  
     ENSP00000450116   ENSP00000448859   ENSP00000448101   ENSP00000448457  
    Reactome Protein details: P60660

    MYL6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for MYL6
    OriGene Protein Over-expression Lysate for MYL6
    OriGene MassSpec for MYL6
    OriGene Custom Protein Services for MYL6
    GenScript Custom Purified and Recombinant Proteins Services for MYL6
    Novus Biologicals MYL6 Proteins
    Novus Biologicals MYL6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MYL6
    Cloud-Clone Corp. Proteins for MYL6

     
    Search eBioscience for Proteins for MYL6 

    MYL6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MYL6
    OriGene Custom Antibody Services for MYL6
    Novus Biologicals MYL6 Antibodies
    Abcam antibodies for MYL6 (Q9Y623, P11055, P05976, P12882, P60660)
    Cloud-Clone Corp. Antibodies for MYL6
    Search ThermoFisher Antibodies for MYL6
    LSBio Antibodies in human, mouse, rat for MYL6

    MYL6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MYL6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MYL6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MYL6
    Cloud-Clone Corp. CLIAs for MYL6
    Search eBioscience for ELISAs for MYL6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    EFHAND: EF-hand domain containing
    MYL: Myosins / Light chain

    2 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom

    Graphical View of Domain Structure for InterPro Entry P60660

    ProtoNet protein and cluster: P60660

    UniProtKB/Swiss-Prot: MYL6_HUMAN, P60660
    Similarity: Contains 3 EF-hand domains


    Find genes that share domains with MYL6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYL6_HUMAN, P60660
    Function: Regulatory light chain of myosin. Does not bind calcium

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity TAS2304459
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
    GO:0008307structural constituent of muscle IDA16953301
    GO:0030898actin-dependent ATPase activity ISS--
         
    Find genes that share ontologies with MYL6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MYL6:
     Decreased focal adhesion (FA)  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYL6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYL6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYL6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYL6

    miRNA
    Products:
        
    miRTarBase miRNAs that target MYL6:
    hsa-mir-106b-5p (MIRT044318), hsa-mir-92a-3p (MIRT049263), hsa-mir-1910-5p (MIRT035801)

    Block miRNA regulation of human, mouse, rat MYL6 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MYL6
    SwitchGear 3'UTR luciferase reporter plasmidMYL6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MYL6
    Predesigned siRNA for gene silencing in human, mouse, rat MYL6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MYL6

    Clone
    Products:
         
    OriGene clones in human, mouse for MYL6 (see all 14)
    OriGene ORF clones in mouse, rat for MYL6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MYL6 (NM_021019)
    Sino Biological Human cDNA Clone for MYL6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYL6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MYL6
    Browse ESI BIO Cell Lines and PureStem Progenitors for MYL6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    nucleus2
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0016459myosin complex TAS2304459
    GO:0016461unconventional myosin complex TAS2304459
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with MYL6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MYL6 About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    3Cell adhesion Integrin mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Development MAG dependent inhibition of neurite outgrowth0.46
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cell adhesion Tight junctions0.33
    4PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    5Semaphorin interactions
    Sema4D in semaphorin signaling0.90
    Semaphorin interactions0.43
    Sema4D induced cell migration and growth-cone collapse0.90


    Find genes that share SuperPaths with MYL6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYL6 (see all 16)
        Activation of PKA through GPCR
    RhoA Pathway
    PKA Signaling
    Guidance Cues and Growth Cone Motility
    Antioxidant Action of Vitamin-C

    Selected GeneGo (Thomson Reuters) Pathways for MYL6 (see all 8)
        Signal transduction Activation of PKC via G-Protein coupled receptor
    Cell adhesion Integrin-mediated cell adhesion and migration
    Inhibitory action of Lipoxins on neutrophil migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils

    1 BioSystems Pathway for MYL6
        Focal Adhesion


    2 Reactome Pathways for MYL6
        Smooth Muscle Contraction
    Sema4D induced cell migration and growth-cone collapse


    2 Kegg Pathways  (Kegg details for MYL6):
        Vascular smooth muscle contraction
    Oxytocin signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYL6
    Interactions:

        Search GeneGlobe Interaction Network for MYL6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYL6 (P606601, 2, 3 ENSP000002934224) via UniProtKB, MINT, STRING, and/or I2D (see all 119)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHUKO151112, 3, ENSP000003594244MINT-48059 I2D: score=2 STRING: ENSP00000359424
    IKBKEQ141642, 3MINT-48122 I2D: score=3 
    IKBKGQ9Y6K92, 3MINT-48230 I2D: score=2 
    MAP3K3Q997592, 3MINT-48505 I2D: score=2 
    RIPK3Q9Y5722, 3MINT-49150 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process ISS--
    GO:0006936muscle contraction TAS2304459
    GO:0007411axon guidance TAS--
    GO:0007519skeletal muscle tissue development TAS2304459
    GO:0008152metabolic process TAS2304459

    Find genes that share ontologies with MYL6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MYL6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BTSSelective inhibitor of skeletal muscle myosin II ATPase activity[1576-37-0]
    (R)-(+)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)[1177356-70-5]
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)[856925-71-8]
    (+-)-BlebbistatinSelective inhibitor of myosin II ATPase activity[674289-55-5]

    1 HMDB Compound for MYL6    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MYL6 gene (3 alternative transcripts): 
    NM_021019.4  NM_079423.3  NM_079425.1  

    Unigene Cluster for MYL6:

    Myosin, light chain 6, alkali, smooth muscle and non-muscle
    Hs.632717  [show with all ESTs]
    Unigene Representative Sequence: BM546656
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000550697(uc001sjw.2 uc001sjx.2 uc010sqe.2) ENST00000548580
    ENST00000550184 ENST00000552297 ENST00000293422 ENST00000348108 ENST00000549017
    ENST00000547703 ENST00000549566 ENST00000536128(uc010sqd.2) ENST00000547649
    ENST00000548725 ENST00000547408 ENST00000551589 ENST00000550639 ENST00000546630
    ENST00000549392 ENST00000548400
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MYL6 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MYL6
    SwitchGear 3'UTR luciferase reporter plasmidMYL6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MYL6
    Predesigned siRNA for gene silencing in human, mouse, rat MYL6
    Clone
    Products:
         
    OriGene clones in human, mouse for MYL6 (see all 14)
    OriGene ORF clones in mouse, rat for MYL6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MYL6 (NM_021019)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYL6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MYL6
    OriGene qSTAR qPCR primer pairs in human, mouse for MYL6
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MYL6
      QuantiTect SYBR Green Assays in human, mouse, rat MYL6
      QuantiFast Probe-based Assays in human, mouse, rat MYL6

    Additional mRNA sequence: 

    AB046613.1 AK301198.1 BC006781.2 BC017455.1 BC071661.1 BC093066.1 CR456839.1 CR457014.1 
    M22918.1 M22920.1 M31212.1 U02629.1 

    Selected DOTS entries (see all 108):

    DT.95347289  DT.100864340  DT.91913654  DT.91959871  DT.100695392  DT.100869803  DT.95137345  DT.95137558 
    DT.92472009  DT.100060351  DT.95137407  DT.95137429  DT.100695397  DT.455782  DT.92472124  DT.95116117 
    DT.100695414  DT.100695407  DT.120745  DT.100060350  DT.95135830  DT.100695403  DT.121141248  DT.121141294 

    Selected AceView cDNA sequences (see all 2991):

    AL600764 BI713122 BG490283 BM696683 BQ931674 BU783781 CF129205 CA942552 
    CA841248 AI313116 CD107880 AA393811 AW573552 BM311313 AV745652 CA867947 
    N20481 AA688199 BU507825 CB111250 AA075398 AA064903 CF528376 BU626129 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MYL6 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c
    SP1:                                                              -                 -                     
    SP2:                    -     -     -     -                       -     -     -     -                     
    SP3:                                      -                       -                                       
    SP4:                                      -                       -     -     -     -                     
    SP5:                                      -     -                 -     -     -     -                     


    ECgene alternative splicing isoforms for MYL6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MYL6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCTGAATG
    MYL6 Expression
    About this image


    MYL6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    MYL6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYL6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632717
        Custom PCR Arrays for MYL6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MYL6
    OriGene qSTAR qPCR primer pairs in human, mouse for MYL6
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MYL6
    QuantiTect SYBR Green Assays in human, mouse, rat MYL6
    QuantiFast Probe-based Assays in human, mouse, rat MYL6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYL6 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myl61 , 5 myosin, light polypeptide 6, alkali, smooth muscle more1, 5 95.58(n)1
    100(a)1
      10 (76.75 cM)5
    179041  NM_010860.31  NP_034990.11 
     1284908615 
    lizard
    (Anolis carolinensis)
    Reptilia MYL66
    myosin, light chain 6, alkali, smooth muscle and n...
    93(a)
    1 ↔ 1
    2(93814860-93823920)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.55162 Xenopus laevis transcribed sequence with moderate similarity more 78.21(n)    48052435 
    zebrafish
    (Danio rerio)
    Actinopterygii CB356795.12   -- 80.92(n)    CB356795.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mlc-c1 , 3 myosin ATPase3
    Myosin light chain cytoplasmic1
    53(a)3
    59.64(n)1
    55.78(a)1
      5A83
    314741  NM_078494.31  NP_511049.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T12D8.63
    mlc-51
    EF hand3
    mlc-51
    47(a)3
    54.61(n)1
    48.94(a)1
      III(13694513-13695376)3
    1767961  NM_067412.61  NP_499813.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MLC16
    Essential light chain for Myo1p, light chain for M...
    34(a)
    1 → many
    VII(306560-307009) YGL106W


    ENSEMBL Gene Tree for MYL6 (if available)
    TreeFam Gene Tree for MYL6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MYL6 gene
    MYL42  MYL6B2  MYL12  MYL32  
    Selected SIMAP similar genes for MYL6 using alignment to 13 protein entries:     MYL6_HUMAN (see all proteins) (see all similar genes):
    MYL1    MYL4    MYL3    MYL6B    CALM2    CALM1
    CALML3    CALM3    TNNC2    CABP5    CALML5    CETN1
    CETN2    CABP1    TNNC1    MYL2    CABP2    MYL10

    Find genes that share paralogs with MYL6           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for MYL6
    PGOHUM00000238506 PGOHUM00000237502 PGOHUM00000239089 PGOHUM00000261329 PGOHUM00000261513


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MYL6 (see all 206)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1487731011,2
    --56384382(+) GGTTGC/TGGTGA 2 -- us2k10--------
    rs2019531271,2
    C--56384440(+) AGTTT-/AAAAAA 2 -- us2k10--------
    rs1843882281,2
    --56384563(+) GGCAAC/TGTAGT 2 -- us2k10--------
    rs2003054281,2
    --56384584(+) CTCTA-/TTTAAA 2 -- us2k10--------
    rs2006215711,2
    --56384585(+) CTATT-/AATAAAA 2 -- us2k10--------
    rs566858631,2
    C--56384586(+) CTATTT/AAAAAA 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1879507261,2
    C--56384761(+) GTGCAC/TGCTTG 2 -- us2k10--------
    rs1130932921,2
    C--56384885(+) ATCTC-/AAAAAA 2 -- us2k11Minor allele frequency- A:0.00CSA 2
    rs1512807611,2
    --56385152(+) GGAGGC/TGGAGG 2 -- us2k10--------
    rs1400107861,2
    C--56385272(+) GGGAAA/GGGAGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MYL6 (56551945 - 56557280 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MYL6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv482992CNV Complex15286789

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYL6
    DNA2.0 Custom Variant and Variant Library Synthesis for MYL6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609931    OMIM disorders: --


    Find genes that share disorders with MYL6           About GenesLikeMe

    1 Novoseek inferred disease relationship for MYL6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 17131471 (1), 20416286 (1)


    Export disorders for MYL6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MYL6 gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with MYL6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, sequencing, and characterization of smooth muscle myosin alkali light chain from human eye cDNA: homology with myocardial fatty acid ethyl ester synthase-III cDNA. (PubMed id 8188229)1, 2, 3 Bora P.S.... Lange L.G. (Genomics 1994)
    2. Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. (PubMed id 2304459)1, 2, 3 Hailstones D.L. and Gunning P.W. (Mol. Cell. Biol. 1990)
    3. The alkali light chains of human smooth and nonmuscle myosins are encoded by a single gene. Tissue-specific expression by alternative splicing pathways. (PubMed id 2722814)1, 2, 3 Lenz S.... Arnold H.H. (J. Biol. Chem. 1989)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Molecular cloning and sequencing of myosin light chains in human megakaryoblastic leukemia cells. (PubMed id 11436981)1, 2 Watanabe M.... Higashihara M. (J. Smooth Muscle Res. 2001)
    6. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. (PubMed id 23864651)1 Huang X....Wheeler M.B. (Mol. Endocrinol. 2013)
    9. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4637 HGNC: 7587 AceView: MLC1SAandMYL6 Ensembl:ENSG00000092841 euGenes: HUgn4637
    ECgene: MYL6 Kegg: 4637 H-InvDB: MYL6

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MYL6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MYL6 gene:
    Search GeneIP for patents involving MYL6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MYL6   OriGene RNAi products in human, mouse, rat for MYL6  
     OriGene qPCR primer pairs and template standards for MYL6   OriGene Protein Over-expression Lysate for MYL6  
     OriGene MassSpec something-or-other for MYL6   OriGene clones in human, mouse for MYL6  
     OriGene qSTAR qPCR primer pairs in human, mouse for MYL6   OriGene Purified Protein for MYL6  
     OriGene ORF clones in mouse, rat for MYL6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MYL6   OriGene Custom Protein Services for MYL6  

     
     
     Block miRNA regulation of human, mouse, rat MYL6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MYL6
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYL6 Predesigned siRNA for gene silencing in human, mouse, rat MYL6
     QuantiFast Probe-based Assays in human, mouse, rat MYL6 QuantiTect SYBR Green Assays in human, mouse, rat MYL6
     Custom PCR Arrays for MYL6 Search Chromatin IP Primers for MYL6
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MYL6  Search GeneGlobe Interaction Network for MYL6
     Regulatory tfbs in MYL6 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MYL6 GenScript cDNA clones with any tag delivered in your preferred vector for MYL6
     GenScript Custom Assay Services for MYL6 GenScript Custom overexpressing Cell Line Services for MYL6
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for MYL6
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for MYL6
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MYL6 antibodies
     MYL6 proteins
     MYL6 lysates
     Antibodies for MYL6
     See all of Abcam's Antibodies, Kits and Proteins for MYL6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for MYL6
     Proteins for MYL6
     Antibodies for MYL6
     ELISAs for MYL6
     CLIAs for MYL6



     Browse ESI BIO Cell Lines and PureStem Progenitors for MYL6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL6
     SwitchGear 3'UTR luciferase reporter plasmids for MYL6
     SwitchGear Promoter luciferase reporter plasmids for MYL6
     Search ThermoFisher Antibodies for MYL6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYL6
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYL6
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYL6
     LSBio Antibodies in human, mouse, rat for MYL6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for MYL6
      Search eBioscience for proteins for MYL6
      Search eBioscience for elisas for MYL6
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MYL6 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4