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Aliases for MYL6 Gene

Aliases for MYL6 Gene

  • Myosin, Light Chain 6, Alkali, Smooth Muscle And Non-Muscle 2 3
  • Myosin, Light Polypeptide 6, Alkali, Smooth Muscle And Non-Muscle 2 3
  • Myosin Light Chain Alkali 3 3 4
  • 17 KDa Myosin Light Chain 3 4
  • Myosin Light Chain A3 3 4
  • MLC-3 3 4
  • LC17 3 4
  • Smooth Muscle And Nonmuscle Myosin Light Chain Alkali 6 4
  • Myosin Light Polypeptide 6 3
  • Myosin Light Chain 3 4
  • LC17-GI 3
  • LC17-NM 3
  • MLC1SM 3
  • MLC3NM 3
  • MLC3SM 3
  • ESMLC 3
  • LC17A 3
  • LC17B 3

External Ids for MYL6 Gene

Previous GeneCards Identifiers for MYL6 Gene

  • GC12P056485
  • GC12M056741
  • GC12P056263
  • GC12P054832
  • GC12P054834
  • GC12P054838
  • GC12P056552
  • GC12P053591
  • GC12P056554

Summaries for MYL6 Gene

Entrez Gene Summary for MYL6 Gene

  • Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYL6 Gene

MYL6 (Myosin, Light Chain 6, Alkali, Smooth Muscle And Non-Muscle) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and L1CAM interactions. GO annotations related to this gene include calcium ion binding and motor activity. An important paralog of this gene is MYL1.

UniProtKB/Swiss-Prot for MYL6 Gene

  • Regulatory light chain of myosin. Does not bind calcium

Tocris Summary for MYL6 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name), almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II. Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by intracellular Ca2+ concentrations.

Gene Wiki entry for MYL6 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL6 Gene

Genomics for MYL6 Gene

Regulatory Elements for MYL6 Gene

Genomic Location for MYL6 Gene

Start:
56,158,161 bp from pter
End:
56,163,496 bp from pter
Size:
5,336 bases
Orientation:
Plus strand

Genomic View for MYL6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL6 Gene

Proteins for MYL6 Gene

  • Protein details for MYL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60660-MYL6_HUMAN
    Recommended name:
    Myosin light polypeptide 6
    Protein Accession:
    P60660
    Secondary Accessions:
    • P16475
    • P24572
    • P24573
    • Q12790
    • Q561V9
    • Q6IAZ0
    • Q6IPY5

    Protein attributes for MYL6 Gene

    Size:
    151 amino acids
    Molecular mass:
    16930 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains. Interacts with SPATA6.

    Alternative splice isoforms for MYL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYL6 Gene

Proteomics data for MYL6 Gene at MOPED

Post-translational modifications for MYL6 Gene

  • Ubiquitination at Lys26, Lys50, Lys56, Lys63, and Lys81
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MYL6 Gene

Domains for MYL6 Gene

Gene Families for MYL6 Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • MYL :Myosins / Light chain

Protein Domains for MYL6 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P60660

UniProtKB/Swiss-Prot:

MYL6_HUMAN :
  • P60660
Domain:
  • Contains 3 EF-hand domains.
genes like me logo Genes that share domains with MYL6: view

Function for MYL6 Gene

Molecular function for MYL6 Gene

UniProtKB/Swiss-Prot Function: Regulatory light chain of myosin. Does not bind calcium

Gene Ontology (GO) - Molecular Function for MYL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity TAS 2304459
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 21182205
GO:0008307 structural constituent of muscle IDA 16953301
GO:0030898 actin-dependent ATPase activity ISS --
genes like me logo Genes that share ontologies with MYL6: view

Phenotypes for MYL6 Gene

GenomeRNAi human phenotypes for MYL6:
genes like me logo Genes that share phenotypes with MYL6: view

Animal Model Products

CRISPR Products

miRNA for MYL6 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYL6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MYL6 Gene

Localization for MYL6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYL6 Gene COMPARTMENTS Subcellular localization image for MYL6 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MYL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005903 brush border IDA 22114352
GO:0016020 membrane IDA 19946888
GO:0016459 myosin complex TAS 2304459
GO:0016461 unconventional myosin complex TAS 2304459
genes like me logo Genes that share ontologies with MYL6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYL6 Gene

Pathways for MYL6 Gene

genes like me logo Genes that share pathways with MYL6: view

Gene Ontology (GO) - Biological Process for MYL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006936 muscle contraction TAS 2304459
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007411 axon guidance TAS --
GO:0007519 skeletal muscle tissue development TAS 2304459
genes like me logo Genes that share ontologies with MYL6: view

Compounds for MYL6 Gene

(4) Tocris Compounds for MYL6 Gene

Compound Action Cas Number
(�)-Blebbistatin Selective inhibitor of myosin II ATPase activity [674289-55-5]
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (�)-blebbistatin (Cat. No. 1760) [1177356-70-5]
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (�)-blebbistatin (Cat. No. 1760) [856925-71-8]
BTS Selective inhibitor of skeletal muscle myosin II ATPase activity [1576-37-0]

(1) HMDB Compounds for MYL6 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with MYL6: view

Transcripts for MYL6 Gene

Unigene Clusters for MYL6 Gene

Myosin, light chain 6, alkali, smooth muscle and non-muscle:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYL6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYL6 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c
SP1: - -
SP2: - - - - - - - -
SP3: - -
SP4: - - - - -
SP5: - - - - - -
SP6: -
SP7: - - - -
SP8:
SP9: -
SP10: -

Relevant External Links for MYL6 Gene

GeneLoc Exon Structure for
MYL6
ECgene alternative splicing isoforms for
MYL6

Expression for MYL6 Gene

mRNA expression in normal human tissues for MYL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYL6 Gene

SOURCE GeneReport for Unigene cluster for MYL6 Gene Hs.632717

genes like me logo Genes that share expressions with MYL6: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MYL6 Gene

Orthologs for MYL6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYL6 35
  • 96.69 (n)
  • 96.69 (a)
MYL6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYL6 35
  • 91.61 (n)
  • 96.69 (a)
MYL6 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYL6 35
  • 95.14 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Myl6 35
  • 95.58 (n)
  • 100 (a)
Myl6 16
Myl6 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myl6 35
  • 93.6 (n)
  • 100 (a)
lizard
(Anolis carolinensis)
Reptilia MYL6 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5516 35
tropical clawed frog
(Silurana tropicalis)
Amphibia myl6 35
  • 72.19 (n)
  • 74.83 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.55 35
zebrafish
(Danio rerio)
Actinopterygii myl6 36
  • 73 (a)
ManyToMany
zgc:153867 35
  • 77.48 (n)
  • 84.11 (a)
zgc:153867 36
  • 55 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007806 35
  • 57.53 (n)
  • 52.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mlc-c 35
  • 59.64 (n)
  • 55.78 (a)
Mlc-c 36
  • 49 (a)
OneToMany
Mlc-c 37
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea mlc-5 35
  • 54.61 (n)
  • 48.94 (a)
mlc-5 36
  • 48 (a)
ManyToMany
mlc-6 36
  • 44 (a)
ManyToMany
T12D8.6 37
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MLC1 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.211 36
  • 54 (a)
ManyToMany
CSA.4806 36
  • 46 (a)
ManyToMany
CSA.6288 36
  • 46 (a)
ManyToMany
CSA.6678 36
  • 45 (a)
ManyToMany
Species with no ortholog for MYL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYL6 Gene

ENSEMBL:
Gene Tree for MYL6 (if available)
TreeFam:
Gene Tree for MYL6 (if available)

Paralogs for MYL6 Gene

Paralogs for MYL6 Gene

genes like me logo Genes that share paralogs with MYL6: view

Variants for MYL6 Gene

Sequence variations from dbSNP and Humsavar for MYL6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs13997 -- 56,161,334(-) GGTAC(C/G)CCAAG intron-variant
rs1050470 - 56,160,106(+) ATGGC(A/C)CCGTC reference, missense
rs1050699 -- 56,160,269(+) AAGTA(A/G)AGATG missense, reference
rs1131229 -- 56,160,144(+) GTCAC(A/C)CTGGG reference, synonymous-codon
rs1131230 -- 56,160,145(+) TCACA(A/C)TGGGT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for MYL6 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV Complex 15286789

Relevant External Links for MYL6 Gene

HapMap Linkage Disequilibrium report
MYL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYL6 Gene

Disorders for MYL6 Gene

(1) Novoseek inferred disease relationships for MYL6 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2
genes like me logo Genes that share disorders with MYL6: view

No data available for UniProtKB/Swiss-Prot for MYL6 Gene

Publications for MYL6 Gene

  1. Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. (PMID: 2304459) Hailstones D.L. … Gunning P.W. (Mol. Cell. Biol. 1990) 2 3 4
  2. The alkali light chains of human smooth and nonmuscle myosins are encoded by a single gene. Tissue-specific expression by alternative splicing pathways. (PMID: 2722814) Lenz S. … Arnold H.H. (J. Biol. Chem. 1989) 2 3 4
  3. Molecular cloning, sequencing, and characterization of smooth muscle myosin alkali light chain from human eye cDNA: homology with myocardial fatty acid ethyl ester synthase-III cDNA. (PMID: 8188229) Bora P.S. … Lange L.G. (Genomics 1994) 2 3 4
  4. Molecular cloning and sequencing of myosin light chains in human megakaryoblastic leukemia cells. (PMID: 11436981) Watanabe M. … Higashihara M. (J. Smooth Muscle Res. 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MYL6 Gene

Sources for MYL6 Gene

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