Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MYL5 Gene

Aliases for MYL5 Gene

  • Myosin Light Chain 5 2 3 5
  • Superfast Myosin Regulatory Light Chain 2 3 4
  • Myosin, Light Polypeptide 5, Regulatory 2 3
  • Myosin, Light Chain 5, Regulatory 2 3
  • Myosin Regulatory Light Chain 5 3 4
  • MyLC-2 3 4
  • MYLC2 3 4

External Ids for MYL5 Gene

Previous GeneCards Identifiers for MYL5 Gene

  • GC04P000677
  • GC04P000658
  • GC04P000661

Summaries for MYL5 Gene

Entrez Gene Summary for MYL5 Gene

  • This gene encodes one of the myosin light chains, a component of the hexameric ATPase cellular motor protein myosin. Myosin is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene product, one of the regulatory light chains, is expressed in fetal muscle and in adult retina, cerebellum, and basal ganglia. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYL5 Gene

MYL5 (Myosin Light Chain 5) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Tight junction. GO annotations related to this gene include calcium ion binding and structural constituent of muscle. An important paralog of this gene is MYL10.

Tocris Summary for MYL5 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.

No data available for UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL5 Gene

Genomics for MYL5 Gene

Regulatory Elements for MYL5 Gene

Enhancers for MYL5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F000741 0.4 ENCODE 11.6 +67.5 67528 0.2 MAFK PCGF3 MFSD7 MYL5 ATP5I GC04P000749 ENSG00000248416
GH04F000617 0.2 ENCODE 10.9 -55.8 -55754 0.1 CTBP1 TEAD4 DPF2 FOS MLLT1 FOSL2 TBX21 MYL5 ATP5I GC04M000604 GC04P000592
GH04F000698 1.2 FANTOM5 Ensembl ENCODE 7.9 +26.2 26201 2.0 HDGF PKNOX1 MLX ARID4B ZNF48 SP5 TBX21 KAT8 NFIL3 MIER3 MYL5 LOC101928521 PCGF3 GAK MFSD7
GH04F000946 1 Ensembl 5.6 +273.4 273421 0.4 DGKQ IDUA SLC26A1 MAEA MYL5 GC04M000939 GC04M000940 PIR57975
GH04F000686 0.6 FANTOM5 ENCODE 1.5 +14.9 14920 3.5 HDGF PKNOX1 CREB3L1 SIN3A ARID4B ZNF2 ZNF143 KLF13 SP3 SP5 MFSD7 LOC101928521 PCGF3 GAK MYL5 GC04M000682 GC04M000683
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MYL5 on UCSC Golden Path with GeneCards custom track

Promoters for MYL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001234297 920 1801 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 FOS ZNF263 SP3

Genomic Location for MYL5 Gene

Chromosome:
4
Start:
673,580 bp from pter
End:
682,033 bp from pter
Size:
8,454 bases
Orientation:
Plus strand

Genomic View for MYL5 Gene

Genes around MYL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL5 Gene

Proteins for MYL5 Gene

  • Protein details for MYL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02045-MYL5_HUMAN
    Recommended name:
    Myosin light chain 5
    Protein Accession:
    Q02045
    Secondary Accessions:
    • Q8IXL8

    Protein attributes for MYL5 Gene

    Size:
    173 amino acids
    Molecular mass:
    19534 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains.
    Miscellaneous:
    • This chain binds calcium.

    Alternative splice isoforms for MYL5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYL5 Gene

Post-translational modifications for MYL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYL5 Gene

Domains & Families for MYL5 Gene

Protein Domains for MYL5 Gene

Suggested Antigen Peptide Sequences for MYL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q02045

UniProtKB/Swiss-Prot:

MYL5_HUMAN :
  • Contains 3 EF-hand domains.
Domain:
  • Contains 3 EF-hand domains.
genes like me logo Genes that share domains with MYL5: view

Function for MYL5 Gene

Molecular function for MYL5 Gene

GENATLAS Biochemistry:
myosin,light polypeptide 5,regulatory

Gene Ontology (GO) - Molecular Function for MYL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0008307 structural constituent of muscle TAS 1284596
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MYL5: view
genes like me logo Genes that share phenotypes with MYL5: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYL5 Gene

Localization for MYL5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYL5 Gene COMPARTMENTS Subcellular localization image for MYL5 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MYL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005859 muscle myosin complex TAS 1284596
GO:0016459 myosin complex IEA --
genes like me logo Genes that share ontologies with MYL5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYL5 Gene

Pathways & Interactions for MYL5 Gene

genes like me logo Genes that share pathways with MYL5: view

Gene Ontology (GO) - Biological Process for MYL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS --
GO:0006937 regulation of muscle contraction TAS 1284596
genes like me logo Genes that share ontologies with MYL5: view

No data available for SIGNOR curated interactions for MYL5 Gene

Drugs & Compounds for MYL5 Gene

(3) Drugs for MYL5 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
(R)-(+)-Blebbistatin Pharma non-muscle myosin II ATPases inhibitor, cell-permeable, Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 0
BTS Pharma Selective inhibitor of skeletal muscle myosin II ATPase activity 0

(2) Additional Compounds for MYL5 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-Blebbistatin
674289-55-5
(S)-(-)-Blebbistatin
856925-71-8

(4) Tocris Compounds for MYL5 Gene

Compound Action Cas Number
(+-)-Blebbistatin Selective inhibitor of myosin II ATPase activity 674289-55-5
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 1177356-70-5
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760) 856925-71-8
BTS Selective inhibitor of skeletal muscle myosin II ATPase activity 1576-37-0
genes like me logo Genes that share compounds with MYL5: view

Transcripts for MYL5 Gene

Unigene Clusters for MYL5 Gene

Myosin, light chain 5, regulatory:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYL5 Gene

No ASD Table

Relevant External Links for MYL5 Gene

GeneLoc Exon Structure for
MYL5
ECgene alternative splicing isoforms for
MYL5

Expression for MYL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYL5 Gene

Protein differential expression in normal tissues from HIPED for MYL5 Gene

This gene is overexpressed in Heart (48.4) and Fetal heart (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYL5 Gene



Protein tissue co-expression partners for MYL5 Gene

NURSA nuclear receptor signaling pathways regulating expression of MYL5 Gene:

MYL5

SOURCE GeneReport for Unigene cluster for MYL5 Gene:

Hs.410970

mRNA Expression by UniProt/SwissProt for MYL5 Gene:

Q02045-MYL5_HUMAN
Tissue specificity: Expressed in fetal skeletal muscle and retina.
genes like me logo Genes that share expression patterns with MYL5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MYL5 Gene

Orthologs for MYL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYL5 34 35
  • 99.29 (n)
oppossum
(Monodelphis domestica)
Mammalia MYL5 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYL5 34 35
  • 90.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MYL5 35
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYL5 35
  • 87 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01076669.1 35
  • 66 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea mlc-1 36
  • 51 (a)
mlc-2 36
  • 51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11077 35
  • 62 (a)
ManyToMany
CSA.10194 35
  • 61 (a)
ManyToMany
Species where no ortholog for MYL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MYL5 Gene

ENSEMBL:
Gene Tree for MYL5 (if available)
TreeFam:
Gene Tree for MYL5 (if available)

Paralogs for MYL5 Gene

Paralogs for MYL5 Gene

(15) SIMAP similar genes for MYL5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MYL5: view

Variants for MYL5 Gene

Sequence variations from dbSNP and Humsavar for MYL5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10023220 -- 680,478(+) CCTGA(C/T)GGCCC intron-variant
rs10716 -- 682,005(+) AGCCG(A/G)GTCAA intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs111286981 -- 674,864(+) GCGGC(C/G)CGCGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs111561980 -- 676,786(+) CCTTG(C/T)TCCCA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs111690748 -- 675,994(+) TGATC(C/T)TTTCT intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MYL5 Gene

Variant ID Type Subtype PubMed ID
esv2759217 CNV loss 17122850
esv995514 CNV insertion 20482838
nsv10413 CNV gain 18304495
nsv1110773 CNV insertion 24896259
nsv1143073 CNV tandem duplication 24896259
nsv508986 CNV insertion 20534489
nsv593206 CNV loss 21841781
nsv593208 CNV loss 21841781
nsv822425 CNV loss 20364138
nsv829834 CNV loss 17160897
nsv950325 CNV deletion 24416366

Variation tolerance for MYL5 Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.46; 71.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYL5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYL5 Gene

Disorders for MYL5 Gene

Relevant External Links for MYL5

Genetic Association Database (GAD)
MYL5
Human Genome Epidemiology (HuGE) Navigator
MYL5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYL5

No disorders were found for MYL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYL5 Gene

Publications for MYL5 Gene

  1. The genomic organization of a novel regulatory myosin light chain gene (MYL5) that maps to chromosome 4p16.3 and shows different patterns of expression between primates. (PMID: 1284596) Collins C.C. … Hayden M.R. (Hum. Mol. Genet. 1992) 2 3 4 64
  2. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3 46 64
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  4. Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain endothelial cells. (PMID: 19794400) Zhong Y. … Toborek M. (J. Cereb. Blood Flow Metab. 2010) 3 64
  5. Expanding the substantial interactome of NEMO using protein microarrays. (PMID: 20098747) Fenner B.J. … Prehn J.H. (PLoS ONE 2010) 3 64

Products for MYL5 Gene

Sources for MYL5 Gene

Content
Loading form....