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Aliases for MYL5 Gene

Aliases for MYL5 Gene

  • Myosin, Light Chain 5, Regulatory 2 3
  • Superfast Myosin Regulatory Light Chain 2 3 4
  • Myosin, Light Polypeptide 5, Regulatory 2 3
  • Myosin Regulatory Light Chain 5 3 4
  • MyLC-2 3 4
  • MYLC2 3 4
  • Myosin Light Chain 5 3

External Ids for MYL5 Gene

Previous GeneCards Identifiers for MYL5 Gene

  • GC04P000677
  • GC04P000658
  • GC04P000661

Summaries for MYL5 Gene

Entrez Gene Summary for MYL5 Gene

  • This gene encodes one of the myosin light chains, a component of the hexameric ATPase cellular motor protein myosin. Myosin is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene product, one of the regulatory light chains, is expressed in fetal muscle and in adult retina, cerebellum, and basal ganglia. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYL5 Gene

MYL5 (Myosin, Light Chain 5, Regulatory) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include calcium ion binding and structural constituent of muscle. An important paralog of this gene is MYL12A.

Tocris Summary for MYL5 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name), almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II. Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by intracellular Ca2+ concentrations.

No data available for UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL5 Gene

Genomics for MYL5 Gene

Regulatory Elements for MYL5 Gene

Genomic Location for MYL5 Gene

673,580 bp from pter
682,033 bp from pter
8,454 bases
Plus strand

Genomic View for MYL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL5 Gene

Proteins for MYL5 Gene

  • Protein details for MYL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myosin light chain 5
    Protein Accession:
    Secondary Accessions:
    • Q8IXL8

    Protein attributes for MYL5 Gene

    173 amino acids
    Molecular mass:
    19534 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains
    • This chain binds calcium.

    Alternative splice isoforms for MYL5 Gene


neXtProt entry for MYL5 Gene

Proteomics data for MYL5 Gene at MOPED

Post-translational modifications for MYL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYL5 Gene

No data available for DME Specific Peptides for MYL5 Gene

Domains for MYL5 Gene

Gene Families for MYL5 Gene

  • EFHAND :EF-hand domain containing
  • MYL :Myosins / Light chain

Protein Domains for MYL5 Gene

Suggested Antigen Peptide Sequences for MYL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q02045
  • Contains 3 EF-hand domains.
genes like me logo Genes that share domains with MYL5: view

Function for MYL5 Gene

Molecular function for MYL5 Gene

GENATLAS Biochemistry: myosin,light polypeptide 5,regulatory

Gene Ontology (GO) - Molecular Function for MYL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0008307 structural constituent of muscle TAS 1284596
genes like me logo Genes that share ontologies with MYL5: view

Phenotypes for MYL5 Gene

GenomeRNAi human phenotypes for MYL5:
genes like me logo Genes that share phenotypes with MYL5: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MYL5 Gene

Localization for MYL5 Gene

Subcellular locations from

Jensen Localization Image for MYL5 Gene COMPARTMENTS Subcellular localization image for MYL5 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MYL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005859 muscle myosin complex TAS 1284596
genes like me logo Genes that share ontologies with MYL5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYL5 Gene

Pathways for MYL5 Gene

genes like me logo Genes that share pathways with MYL5: view

Interacting Proteins for MYL5 Gene

Gene Ontology (GO) - Biological Process for MYL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS --
GO:0006937 regulation of muscle contraction TAS 1284596
genes like me logo Genes that share ontologies with MYL5: view

Compounds for MYL5 Gene

(4) Tocris Compounds for MYL5 Gene

Compound Action Cas Number
(�)-Blebbistatin Selective inhibitor of myosin II ATPase activity [674289-55-5]
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (�)-blebbistatin (Cat. No. 1760) [1177356-70-5]
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (�)-blebbistatin (Cat. No. 1760) [856925-71-8]
BTS Selective inhibitor of skeletal muscle myosin II ATPase activity [1576-37-0]

(1) HMDB Compounds for MYL5 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with MYL5: view

Transcripts for MYL5 Gene

Unigene Clusters for MYL5 Gene

Myosin, light chain 5, regulatory:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYL5 Gene

No ASD Table

Relevant External Links for MYL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYL5 Gene

mRNA expression in normal human tissues for MYL5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYL5 Gene

SOURCE GeneReport for Unigene cluster for MYL5 Gene Hs.410970

mRNA Expression by UniProt/SwissProt for MYL5 Gene

Tissue specificity: Expressed in fetal skeletal muscle and retina
genes like me logo Genes that share expressions with MYL5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MYL5 Gene

Orthologs for MYL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MYL5 35
  • 99.29 (n)
  • 100 (a)
MYL5 36
  • 99 (a)
(Canis familiaris)
Mammalia MYL5 35
  • 90.56 (n)
  • 93.64 (a)
MYL5 36
  • 94 (a)
(Monodelphis domestica)
Mammalia MYL5 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia MYL5 36
  • 89 (a)
(Anolis carolinensis)
Reptilia MYL5 36
  • 87 (a)
(Danio rerio)
Actinopterygii CABZ01076669.1 36
  • 66 (a)
(Caenorhabditis elegans)
Secernentea mlc-2 37
  • 51 (a)
mlc-1 37
  • 51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10194 36
  • 61 (a)
CSA.11077 36
  • 62 (a)
Species with no ortholog for MYL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MYL5 Gene

Gene Tree for MYL5 (if available)
Gene Tree for MYL5 (if available)

Paralogs for MYL5 Gene

Paralogs for MYL5 Gene

Selected SIMAP similar genes for MYL5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MYL5: view

Variants for MYL5 Gene

Sequence variations from dbSNP and Humsavar for MYL5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_050459 -

Structural Variations from Database of Genomic Variants (DGV) for MYL5 Gene

Variant ID Type Subtype PubMed ID
nsv878245 CNV Loss 21882294
nsv508986 CNV Insertion 20534489
nsv822425 CNV Loss 20364138
nsv878246 CNV Loss 21882294
dgv1564e1 CNV Complex 17122850
nsv878247 CNV Loss 21882294
dgv5387n71 CNV Loss 21882294
nsv829834 CNV Loss 17160897
nsv10413 CNV Gain 18304495
dgv5388n71 CNV Loss 21882294
esv995514 CNV Insertion 20482838

Relevant External Links for MYL5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYL5 Gene

Disorders for MYL5 Gene

Relevant External Links for MYL5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MYL5: view

No data available for UniProtKB/Swiss-Prot for MYL5 Gene

Publications for MYL5 Gene

  1. The genomic organization of a novel regulatory myosin light chain gene (MYL5) that maps to chromosome 4p16.3 and shows different patterns of expression between primates. (PMID: 1284596) Collins C.C. … Hayden M.R. (Hum. Mol. Genet. 1992) 2 3 4
  2. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3 48
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Isolation and structure of cat superfast myosin light chain-2 cDNA and evidence for the identity of its human homologue. (PMID: 8185576) Qin H. … Hoh J.F. (Biochem. Biophys. Res. Commun. 1994) 23

Products for MYL5 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MYL5
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MYL5
    • Block miRNA regulation of MYL5 using miScript Target Protectors

    Sources for MYL5 Gene

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