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MYL5 Gene

protein-coding   GIFtS: 56
GCID: GC04P000661

Myosin, Light Chain 5, Regulatory

(Previous names: myosin, light polypeptide 5, regulatory)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin, Light Chain 5, Regulatory1 2     MYLC22 3
Myosin, Light Polypeptide 5, Regulatory1 2     myLC-22
Myosin Regulatory Light Chain 52 3     Myosin Light Chain 52
Superfast Myosin Regulatory Light Chain 22 3     MyLC-23

External Ids:    HGNC: 75861   Entrez Gene: 46362   Ensembl: ENSG000002153757   OMIM: 1607825   UniProtKB: Q020453   

Export aliases for MYL5 gene to outside databases

Previous GC identifers: GC04P000677 GC04P000658


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYL5 Gene:
This gene encodes one of the myosin light chains, a component of the hexameric ATPase cellular motor protein
myosin. Myosin is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two
phosphorylatable regulatory light chains. This gene product, one of the regulatory light chains, is expressed in
fetal muscle and in adult retina, cerebellum, and basal ganglia. (provided by RefSeq, Jul 2008)

GeneCards Summary for MYL5 Gene:
MYL5 (myosin, light chain 5, regulatory) is a protein-coding gene. GO annotations related to this gene include structural constituent of muscle and calcium ion binding. An important paralog of this gene is MYL12A.

summary for MYL5 Gene:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYL5 gene promoter:
         SRF   NF-1/L   NF-1   AML1a   SRF (504 AA)   ATF-2   YY1   HEN1   POU2F1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYL5 promoter sequence
   Search Chromatin IP Primers for MYL5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16

MYL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P000661:  view genomic region     (about GC identifiers)

Start:
667,369 bp from pter      End:
675,822 bp from pter
Size:
8,454 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MYL5_HUMAN, Q02045 (See protein sequence)
Recommended Name: Myosin light chain 5  
Size: 173 amino acids; 19534 Da
Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains
Miscellaneous: This chain binds calcium (By similarity)
Secondary accessions: Q8IXL8
Alternative splicing: 2 isoforms:  Q02045-1   Q02045-2   

Explore the universe of human proteins at neXtProt for MYL5: NX_Q02045

Explore proteomics data for MYL5 at MOPED


See MYL5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002468.1  
ENSEMBL proteins: 
 ENSP00000427153   ENSP00000423118   ENSP00000424528   ENSP00000425162   ENSP00000383023  
 ENSP00000423053   ENSP00000427317  

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antibodies-online proteins for MYL5 (10 products) 

 
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antibodies-online antibodies for MYL5 (11 products) 

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
EFHAND: EF-hand domain containing
MYL: Myosins / Light chain

3 InterPro protein domains:
 IPR011992 EF-hand-dom_pair
 IPR002048 EF_hand_dom
 IPR018247 EF_Hand_1_Ca_BS

Graphical View of Domain Structure for InterPro Entry Q02045

ProtoNet protein and cluster: Q02045

UniProtKB/Swiss-Prot: MYL5_HUMAN, Q02045
Similarity: Contains 3 EF-hand domains


Find genes that share domains with MYL5           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:
     Genatlas biochemistry entry for MYL5:
myosin,light polypeptide 5,regulatory

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005509calcium ion binding IEA--
GO:0008307structural constituent of muscle TAS1284596
     
Find genes that share ontologies with MYL5           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for MYL5:
 Decreased focal adhesion (FA)   Increased circadian period len 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for MYL5

miRNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytoskeleton4
cytosol3
mitochondrion2
nucleus2

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005859muscle myosin complex TAS1284596

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MYL5 About   (see all 15)  
See pathways by source

SuperPathContained pathways About
1Immune response CCR3 signaling in eosinophils
Inhibitory action of Lipoxins on neutrophil migration0.51
Immune response CCR3 signaling in eosinophils0.51
2Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA0.77
Activation of PKA through GPCR0.71
cAMP Pathway0.77
PKA Signaling0.56
3Cell adhesion Integrin mediated cell adhesion and migration
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
Development MAG dependent inhibition of neurite outgrowth0.46
Cell adhesion Integrin mediated cell adhesion and migration0.49
Cell adhesion Tight junctions0.33
4PAK Pathway
PAK Pathway0.56
Epithelial Adherens Junctions0.36
Antioxidant Action of Vitamin-C0.56
5Actin Nucleation by ARP-WASP Complex
Actin Nucleation by ARP-WASP Complex0.66
RhoA Pathway0.35


Find genes that share SuperPaths with MYL5           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYL5 (see all 16)
    Activation of PKA through GPCR
RhoA Pathway
PKA Signaling
Guidance Cues and Growth Cone Motility
Antioxidant Action of Vitamin-C

Selected GeneGo (Thomson Reuters) Pathways for MYL5 (see all 6)
    Cell adhesion Integrin-mediated cell adhesion and migration
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
Inhibitory action of Lipoxins on neutrophil migration
Immune response CCR3 signaling in eosinophils
Cell adhesion Tight junctions


4 Kegg Pathways  (Kegg details for MYL5):
    Focal adhesion
Tight junction
Leukocyte transendothelial migration
Regulation of actin cytoskeleton

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYL5
Interactions:

    Search GeneGlobe Interaction Network for MYL5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for MYL5 (Q020453 ENSP000003830234) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
InteractantInteraction Details
GeneCardExternal ID(s)
IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
ACTBENSP000003499604STRING: ENSP00000349960
ACTG1ENSP000003315144STRING: ENSP00000331514
CGNENSP000002716364STRING: ENSP00000271636
MYH10ENSP000002692434STRING: ENSP00000269243
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006937regulation of muscle contraction TAS1284596

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for MYL5 available from Tocris Bioscience    About this table
CompoundAction CAS #
BTSSelective inhibitor of skeletal muscle myosin II ATPase activity[1576-37-0]
(R)-(+)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)[1177356-70-5]
(S)-(-)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)[856925-71-8]
(+-)-BlebbistatinSelective inhibitor of myosin II ATPase activity[674289-55-5]

1 HMDB Compound for MYL5    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MYL5 gene: 
NM_002477.1  

Unigene Cluster for MYL5:

Myosin, light chain 5, regulatory
Hs.410970  [show with all ESTs]
Unigene Representative Sequence: AK123974
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000506838(uc003gat.3) ENST00000505477 ENST00000503300(uc003gau.3)
ENST00000502720 ENST00000511290 ENST00000400159(uc003gav.3) ENST00000513662
ENST00000507804 ENST00000503612
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Primer
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  QuantiFast Probe-based Assays in human, mouse, rat MYL5

Additional mRNA sequence: 

AK123974.1 AK125529.1 BC040050.1 L03785.1 

8 DOTS entries:

DT.75154829  DT.101981561  DT.91696345  DT.99974924  DT.97858529  DT.86993190  DT.91961188  DT.99965324 

Selected AceView cDNA sequences (see all 50):

CD673591 AK125529 BF342982 NM_002477 L03785 BU838213 BM709371 AI874355 
BM907026 BM681727 AA987886 BQ430792 F15890 BC040050 BU169299 AK123974 
BE904227 BQ051107 CD673590 AI971042 BF718525 AI985293 BF884203 BU732750 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MYL5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTCTGAACC
MYL5 Expression
About this image

MYL5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MYL5 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.410970

UniProtKB/Swiss-Prot: MYL5_HUMAN, Q02045
Tissue specificity: Expressed in fetal skeletal muscle and retina

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MYL5 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia MYL51 myosin, light chain 5, regulatory 90.56(n)
93.64(a)
  479135  XM_005618715.1  XP_005618772.1 
lizard
(Anolis carolinensis)
Reptilia MYL56
myosin, light chain 5, regulatory
87(a)
1 ↔ 1
GL343201.1(690964-699524)
zebrafish
(Danio rerio)
Actinopterygii CABZ01076669.16
Uncharacterized protein
66(a)
many ↔ many
5(689947-710415) ENSDARG00000043349


ENSEMBL Gene Tree for MYL5 (if available)
TreeFam Gene Tree for MYL5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MYL5 gene
MYL12A2  MYL102  MYL72  MYL92  MYL22  MYLPF2  MYL12B2  
15 SIMAP similar genes for MYL5 using alignment to 4 protein entries:     MYL5_HUMAN (see all proteins):
MYLPF    MYL7    MYL2    MYL12A    MYL9    MYL12B
CALM2    CALM1    CALM3    CALML3    MYL10    CETN1
CETN2    CETN3    CALML4

Find genes that share paralogs with MYL5           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MYL5 (see all 155)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1480508841,2
--670216(+) CAATGG/TAGACT 1 -- us2k10--------
rs1876207631,2
--670232(+) TTGCTC/TAAGGC 1 -- us2k10--------
rs1165947341,2
C,F--670263(+) TGGGAC/TGGGTC 1 -- us2k12Minor allele frequency- T:0.02WA NA 238
rs1140816321,2
C,F--670287(+) CACACC/TGCCCG 1 -- us2k11Minor allele frequency- T:0.02WA 118
rs1925422291,2
--670337(+) AAGCCA/GATACT 1 -- us2k10--------
rs1181638521,2
F--670479(+) CCCCTC/TGGTGT 1 -- us2k11Minor allele frequency- T:0.01EA 120
rs1172113111,2
C,F--670671(+) ACCTCA/GGGAGT 1 -- us2k11Minor allele frequency- G:0.02EA 120
rs1144507501,2
C,F--670830(+) TGGCGC/TCCCCA 1 -- us2k12Minor allele frequency- T:0.10WA NA 238
rs1841876111,2
C--670895(+) AGCACC/TGAGGG 1 -- us2k10--------
rs1901850251,2
C--671044(+) AACCAA/GGGCAT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for MYL5 (667369 - 675822 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for MYL5 (see all 11):    About this table    
Variant IDTypeSubtypePubMed ID
nsv508986CNV Insertion20534489
esv995514CNV Insertion20482838
dgv5388n71CNV Loss21882294
nsv822425CNV Loss20364138
nsv878245CNV Loss21882294
nsv878247CNV Loss21882294
nsv878246CNV Loss21882294
dgv5387n71CNV Loss21882294
nsv829834CNV Loss17160897
nsv10413CNV Gain18304495

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MYL5
DNA2.0 Custom Variant and Variant Library Synthesis for MYL5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 160782    OMIM disorders: --


Find genes that share disorders with MYL5           About GenesLikeMe

Genetic Association Database (GAD): MYL5
Human Genome Epidemiology (HuGE) Navigator: MYL5 (1 document)

Export disorders for MYL5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MYL5 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MYL5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The genomic organization of a novel regulatory myosin light chain gene (MYL5) that maps to chromosome 4p16.3 and shows different patterns of expression between primates. (PubMed id 1284596)1, 2, 3 Collins C.C.... Hayden M.R. (Hum. Mol. Genet. 1992)
  2. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  4. Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain endothelial cells. (PubMed id 19794400)1 Zhong Y....Toborek M. (J. Cereb. Blood Flow Metab. 2010)
  5. Expanding the substantial interactome of NEMO using protein microarrays. (PubMed id 20098747)1 Fenner B.J....Prehn J.H. (PLoS ONE 2010)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  9. Myosins: a diverse superfamily. (PubMed id 10722873)1 Sellers J.R. (Biochim. Biophys. Acta 2000)
  10. Isolation and structure of cat superfast myosin light chain-2 cDNA and evidence for the identity of its human homologue. (PubMed id 8185576)9 Qin H....Hoh J.F. (Biochem. Biophys. Res. Commun. 1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4636 HGNC: 7586 AceView: MYL5 Ensembl:ENSG00000215375 euGenes: HUgn4636
ECgene: MYL5 Kegg: 4636 H-InvDB: MYL5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MYL5 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MYL5 gene:
Search GeneIP for patents involving MYL5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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