Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYL4 Gene

protein-coding   GIFtS: 64
GCID: GC17P045286

Myosin, Light Chain 4, Alkali; Atrial, Embryonic

(Previous names: myosin, light polypeptide 4, alkali; atrial, embryonic)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Myosin, Light Chain 4, Alkali; Atrial, Embryonic1 2     ALC12
Myosin, Light Polypeptide 4, Alkali; Atrial, Embryonic1 2     AMLC2
Myosin Light Chain 1, Embryonic Muscle/Atrial Isoform2 3     GT12
Myosin Light Chain Alkali GT-1 Isoform2 3     Myosin Light Chain 42
Atrial/Fetal Muscle1     Myosin, Atrial/Fetal Muscle, Light Chain2
Light Chain1     MLC13
myosin1     

External Ids:    HGNC: 75851   Entrez Gene: 46352   Ensembl: ENSG000001983367   OMIM: 1607705   UniProtKB: P128293   

Export aliases for MYL4 gene to outside databases

Previous GC identifers: GC17P044784 GC17P047685 GC17P045619 GC17P045761 GC17P042641 GC17P040664


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYL4 Gene:
Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two
nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This
gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively
spliced transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for MYL4 Gene: 
MYL4 (myosin, light chain 4, alkali; atrial, embryonic) is a protein-coding gene. Diseases associated with MYL4 include herpes gestationis, and scrapie, and among its related super-pathways are Striated Muscle Contraction and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include structural constituent of muscle and calcium ion binding. An important paralog of this gene is MYL6B.

UniProtKB/Swiss-Prot: MYL4_HUMAN, P12829
Function: Regulatory light chain of myosin. Does not bind calcium

summary for MYL4 Gene:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYL4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYL4 gene promoter:
         GATA-3   NF-kappaB2   Zic1   RelA   NF-kappaB1   NF-kappaB   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYL4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MYL4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

MYL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P045286:  view genomic region     (about GC identifiers)

Start:
45,277,812 bp from pter      End:
45,301,045 bp from pter
Size:
23,234 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MYL4_HUMAN, P12829 (See protein sequence)
Recommended Name: Myosin light chain 4  
Size: 197 amino acids; 21565 Da
Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains
Secondary accessions: D3DXJ7 P11783

Explore the universe of human proteins at neXtProt for MYL4: NX_P12829

Explore proteomics data for MYL4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P12829

  • MYL4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MYL4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001002841.1  NP_002467.1  

    ENSEMBL proteins: 
     ENSP00000459035   ENSP00000461570   ENSP00000458194   ENSP00000458907   ENSP00000442375  
     ENSP00000460734   ENSP00000377096   ENSP00000461747   ENSP00000461121   ENSP00000347055  
    Reactome Protein details: P12829
    Human Recombinant Protein Products for MYL4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for MYL4
    OriGene Protein Over-expression Lysate for MYL4
    OriGene MassSpec for MYL4 
    OriGene Custom Protein Services for MYL4
    GenScript Custom Purified and Recombinant Proteins Services for MYL4
    Novus Biologicals MYL4 Proteins
    Novus Biologicals MYL4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MYL4
    Cloud-Clone Corp. Proteins for MYL4 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005859muscle myosin complex NAS--
    GO:0031672A band IMP14985854

    MYL4 for ontologies           About GeneDecksing



    MYL4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MYL4
    OriGene Custom Antibody Services for MYL4
    GenScript Custom Superior Antibodies Services for MYL4
    Novus Biologicals MYL4 Antibodies
    Abcam antibodies for MYL4
    Cloud-Clone Corp. Antibodies for MYL4 
    Search ThermoFisher Antibodies for MYL4
    LSBio Antibodies in human, mouse, rat for MYL4 

    Assay Products for MYL4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MYL4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MYL4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MYL4 
    Cloud-Clone Corp. CLIAs for MYL4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing
    MYL: Myosins / Light chain

    2 InterPro protein domains:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom

    Graphical View of Domain Structure for InterPro Entry P12829

    ProtoNet protein and cluster: P12829

    UniProtKB/Swiss-Prot: MYL4_HUMAN, P12829
    Similarity: Contains 3 EF-hand domains


    MYL4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYL4_HUMAN, P12829
    Function: Regulatory light chain of myosin. Does not bind calcium

         Genatlas biochemistry entry for MYL4:
    myosin,light polypeptide 4,alkali,atrial,skeletal,embryonic,same as MLC1-A & MLC1-EMB

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003785actin monomer binding IDA9180271
    GO:0005509calcium ion binding IEA--
    GO:0008307structural constituent of muscle NAS--
    GO:0032038myosin II heavy chain binding NAS16675844
    GO:0051015actin filament binding IMP9738905
         
    MYL4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MYL4:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MYL4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MYL4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYL4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYL4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYL4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MYL4
    SwitchGear 3'UTR luciferase reporter plasmidMYL4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MYL4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYL4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MYL4
    Sirion Biotech Customized adenovirus for overexpression of MYL4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MYL4 (see all 13)
    OriGene ORF clones in mouse, rat for MYL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MYL4 (NM_001002841)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYL4
    Sirion Biotech Customized lentivirus for stable overexpression of MYL4 
                         Customized lentivirus expression plasmids for stable overexpression of MYL4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MYL4
    LifeMap BioReagents: cell line associated with MYL4: PureStem Z11, Meso Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MYL4 About   (see all 16)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Striated Muscle Contraction
    Striated Muscle Contraction0.87
    Muscle contraction0.65
    Striated Muscle Contraction0.87
    2Immune response CCR3 signaling in eosinophils
    Immune response CCR3 signaling in eosinophils0.51
    Inhibitory action of Lipoxins on neutrophil migration0.51
    3Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    4PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    5Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin-mediated cell adhesion and migration0.49
    Cell adhesion Tight junctions0.33
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 EMD Millipore Pathways for MYL4 (see all 7)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils

    5/16 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYL4 (see all 16)
        Activation of PKA through GPCR
    RhoA Pathway
    PKA Signaling
    Guidance Cues and Growth Cone Motility
    Antioxidant Action of Vitamin-C

    5/8 GeneGo (Thomson Reuters) Pathways for MYL4 (see all 8)
        Signal transduction Activation of PKC via G-Protein coupled receptor
    Cell adhesion Integrin-mediated cell adhesion and migration
    Inhibitory action of Lipoxins on neutrophil migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils

    2 BioSystems Pathways for MYL4
        Myometrial Relaxation and Contraction Pathways
    Striated Muscle Contraction

    2        Reactome Pathways for MYL4
        Muscle contraction
    Striated Muscle Contraction



    MYL4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for MYL4 (P128293 ENSP000003470554) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    SLC2A4P146723I2D: score=1 
    ACTN2ENSP000003555374STRING: ENSP00000355537
    DESENSP000003630714STRING: ENSP00000363071
    DMDENSP000003549234STRING: ENSP00000354923
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002026regulation of the force of heart contraction IMP16675844
    GO:0007517muscle organ development NAS--
    GO:0030049muscle filament sliding TAS--
    GO:0032781positive regulation of ATPase activity IMP9738905
    GO:0060048cardiac muscle contraction IMP14985854

    MYL4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MYL4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MYL4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BTSSelective inhibitor of skeletal muscle myosin II ATPase activity[1576-37-0]
    (R)-(+)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)[1177356-70-5]
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)[856925-71-8]
    (+-)-BlebbistatinSelective inhibitor of myosin II ATPase activity[674289-55-5]

    1 HMDB Compound for MYL4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for MYL4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatinine 11.1 4 8164150 (1), 8002273 (1), 8803720 (1)

    Search CenterWatch for drugs/clinical trials and news about MYL4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYL4 gene (2 alternative transcripts): 
    NM_001002841.1  NM_002476.2  

    Unigene Cluster for MYL4:

    Myosin, light chain 4, alkali; atrial, embryonic
    Hs.463300  [show with all ESTs]
    Unigene Representative Sequence: BM919855
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000571981 ENST00000572316 ENST00000570772 ENST00000576874 ENST00000536623
    ENST00000573747 ENST00000393450(uc002ilh.3) ENST00000572303 ENST00000570671
    ENST00000354968(uc002ilg.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYL4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MYL4
    SwitchGear 3'UTR luciferase reporter plasmidMYL4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MYL4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYL4
    Clone
    Products:
         
    OriGene clones in human, mouse for MYL4 (see all 13)
    OriGene ORF clones in mouse, rat for MYL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MYL4 (NM_001002841)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYL4
    Sirion Biotech Customized lentivirus for stable overexpression of MYL4 
                         Customized lentivirus expression plasmids for stable overexpression of MYL4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MYL4
    OriGene qSTAR qPCR primer pairs in human, mouse for MYL4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MYL4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYL4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYL4

    Additional mRNA sequence: 

    BC030228.1 M20641.1 M24121.1 M36172.1 X13955.1 

    8 DOTS entries:

    DT.100775232  DT.40121324  DT.95371904  DT.100775236  DT.95371903  DT.91970157  DT.95351169  DT.95371898 

    24/127 AceView cDNA sequences (see all 127):

    BQ636631 AI630404 N75417 W25367 H64136 BI832777 N45243 BC030228 
    BU736020 BU738574 AI355715 NM_001002841 NM_002476 BI835446 N70584 M36172 
    T28197 BU658814 X13955 BX102443 BU656102 H83944 BQ058045 AI131112 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MYL4 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9
    SP1:                                -           -                             -         
    SP2:                                            -                             -         
    SP3:                                            -                                       
    SP4:                                -           -                                       
    SP5:                                                                                    


    ECgene alternative splicing isoforms for MYL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYL4 expression in normal human tissues (normalized intensities)      MYL4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGGGTGAA
    MYL4 Expression
    About this image


    MYL4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 14 entries
             Cardiomyocytes Right Atrium
             Heart Tube
             Cardiomyocyte-like progenitor cells ( Derivation of cardiomyocytes from pluripotent...
             heart/atrium   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 7 entries
             Multinuclear Myocyte Extraocular Muscles
             Human Skeletal Muscle Satellite Cells (HSkMSC)   
             cavities and their linings/intraembryonic coelom/diaphragm   
     
     Blood (Hematopoietic System)    fully expand to see all 6 entries
             Fetal Liver CD36+ Cells   
             reticulocytes   
     
     Limb (Muscoskeletal System)    fully expand to see all 6 entries
             Mesenchymal Condensate Cells Zeugopod
             Autopod
             limb/hindlimb/hind-paw   
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Long Bone
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
             bone marrow   

    See MYL4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYL4

    SOURCE GeneReport for Unigene cluster: Hs.463300
        SABiosciences Custom PCR Arrays for MYL4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MYL4
    OriGene qSTAR qPCR primer pairs in human, mouse for MYL4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MYL4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYL4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYL4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYL4 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myl41 , 5 myosin, light polypeptide 41, 5 87.39(n)1
    91.19(a)1
      11 (67.79 cM)5
    178961  NM_010858.41  NP_034988.21 
     1045506635 
    chicken
    (Gallus gallus)
    Aves MYL41 myosin, light chain 4, alkali; atrial, embryonic 79.46(n)
    84.86(a)
      396472  XM_003642780.1  XP_003642828.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYL46
    myosin, light chain 4, alkali; atrial, embryonic
    85(a)
    1 ↔ 1
    6(67285088-67297824)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX850142.12   -- 78.57(n)    BX850142.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cmlc11 cardiac myosin light chain-1 70.07(n)
    75.51(a)
      64671  NM_131692.1  NP_571767.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mlc-c3 myosin ATPase 53(a)   5A8   --
    worm
    (Caenorhabditis elegans)
    Secernentea T12D8.63 EF hand 46(a)   III(13694513-13695376)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MLC16
    Essential light chain for Myo1p, light chain for M...
    36(a)
    1 → many
    VII(306560-307009)


    ENSEMBL Gene Tree for MYL4 (if available)
    TreeFam Gene Tree for MYL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYL4 gene
    MYL6B2  MYL12  MYL62  MYL32  
    11 SIMAP similar genes for MYL4 using alignment to 6 protein entries:     MYL4_HUMAN (see all proteins):
    MYL6    MYL3    MYL1    CALM3    CALM2    MYL6B
    CALM1    CALML3    CALML4    TNNC2    TNNC1

    MYL4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/393 SNPs in MYL4 are shown (see all 393)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs733271871,2
    C,F--45284489(+) CAAAGG/TAGCCA 1 -- us2k12Minor allele frequency- T:0.10WA 120
    rs1436916261,2
    --45284643(+) AGGAGA/GAGCAG 1 -- us2k10--------
    rs1846143551,2
    --45284648(+) GAGCAA/GTGAAG 1 -- us2k10--------
    rs733271901,2
    C,F--45284684(+) ACCCCA/GGGAAA 1 -- us2k12Minor allele frequency- G:0.10WA 120
    rs733271921,2
    C,F--45284745(+) AACTTC/AAACGT 2 -- us2k12Minor allele frequency- A:0.10WA 120
    rs98943651,2
    C,F,A,H--45284787(+) ACAGCA/GTGGGG 2 -- us2k122Minor allele frequency- G:0.48NS EA NA WA CSA 2334
    rs1886860991,2
    --45284875(+) AATGGA/GCAGAT 2 -- us2k10--------
    rs1807640041,2
    --45284908(+) TTGCAC/GGCTTA 2 -- us2k10--------
    rs1161688101,2
    F--45284963(+) TACAGG/ATGAGG 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1146192511,2
    C,F--45284993(+) GAAGTG/TATTTT 2 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for MYL4 (45277812 - 45301045 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MYL4: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MYL4
    DNA2.0 Custom Variant and Variant Library Synthesis for MYL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 160770    OMIM disorders: --

    7 diseases for MYL4:    About MalaCards
    herpes gestationis    scrapie    acute myocardial infarction    toxoplasmosis
    myocardial infarction    rhabdomyosarcoma    myopathy

    1 disease from the University of Copenhagen DISEASES database for MYL4:
    Herpes gestationis

    MYL4 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for MYL4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ventricular aneurysm 77.9 3 7857308 (2)
    aortic stenosis 48 2 1533180 (2)
    congenital heart disease 40.4 3 8755658 (1), 16106982 (1), 14985854 (1)
    acute myocardial infarction 23.3 2 8164150 (1)
    myocardial infarction 10.8 4 8164150 (1), 1451244 (1), 7602751 (1)
    infarct 5.44 4 7602751 (2), 8164150 (1)

    Genetic Association Database (GAD): MYL4

    Export disorders for MYL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYL4 gene, integrated from 9 sources (see all 51):
    (articles sorted by number of sources associating them with MYL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human atrial and ventricular myosin alkali light chain cDNA clones. (PubMed id 3417683)1, 2, 3 Kurabayashi M.... Yazaki Y. (1988)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The human embryonic myosin alkali light chain gene: use of alternative promoters and 3' non-coding regions. (PubMed id 2027757)1, 2 Rotter M.... Starzinski-Powitz A. (1991)
    4. Heterogenic mRNAs with an identical protein-coding region of the human embryonic myosin alkali light chain in skeletal muscle cells. (PubMed id 2308163)1, 2 Zimmermann K....Starzinski-Powitz A. (1990)
    5. Human embryonic/atrial myosin alkali light chain gene: characterization, sequence, and chromosomal location. (PubMed id 2129532)1, 2 Seharaseyon J.... Vanin E.F. (1990)
    6. Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms. (PubMed id 2458299)1, 2 Seidel U.... Arnold H.H. (1988)
    7. A novel human myosin alkali light chain is developmentally regulated. Expression in fetal cardiac and skeletal muscle and in adult atria. (PubMed id 2849544)1, 2 Arnold H.H.... Bober E. (1988)
    8. Proteomic analysis of pharmacologically preconditioned cardiomyocytes reveals novel phosphorylation of myosin light chain 1. (PubMed id 11557734)1, 9 Arrell D.K....Van Eyk J.E. (2001)
    9. Human atrial myosin light chain 1 expression attenuates heart failure. (PubMed id 16106982)1, 9 Abdelaziz A.I....Morano I. (2005)
    10. Functional characterization of the human atrial essential myosin light chain (hALC-1) in a transgenic rat model. (PubMed id 14985854)1, 9 Abdelaziz A.I....Morano I. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4635 HGNC: 7585 AceView: MYL4 Ensembl:ENSG00000198336 euGenes: HUgn4635
    ECgene: MYL4 H-InvDB: MYL4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYL4 gene:
    Search GeneIP for patents involving MYL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MYL4   OriGene RNAi products in human, mouse, rat for MYL4  
     OriGene qPCR primer pairs and template standards for MYL4   OriGene Protein Over-expression Lysate for MYL4  
     OriGene MassSpec something-or-other for MYL4   OriGene clones in human, mouse for MYL4  
     OriGene qSTAR qPCR primer pairs in human, mouse for MYL4   OriGene Purified Protein for MYL4  
     OriGene ORF clones in mouse, rat for MYL4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MYL4   OriGene Custom Protein Services for MYL4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MYL4
     QIAGEN SeqTarget long-range PCR primers for resequencing MYL4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYL4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYL4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYL4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYL4
     GenScript Custom Purified and Recombinant Proteins Services for MYL4 GenScript cDNA clones with any tag delivered in your preferred vector for MYL4
     GenScript Custom Assay Services for MYL4 GenScript Custom Superior Antibodies Services for MYL4
     GenScript Custom overexpressing Cell Line Services for MYL4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MYL4 promoter
     Search Chromatin IP Primers for MYL4
     RT2 qPCR Primer Assay in human, mouse, rat MYL4
     Search GNC Networks for MYL4
     SABiosciences PCR Arrays including human, mouse, rat MYL4
     Tocris compounds for MYL4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MYL4 antibodies
     MYL4 proteins
     MYL4 lysates
     Antibodies for MYL4
     See all of Abcam's Antibodies, Kits and Proteins for MYL4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for MYL4




     Proteins for MYL4
     Antibodies for MYL4
     ELISAs for MYL4
     CLIAs for MYL4
     Cell Line associated with MYL4: PureStem Z11, Meso Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL4
     SwitchGear 3'UTR luciferase reporter plasmids for MYL4
     SwitchGear Promoter luciferase reporter plasmids for MYL4
     Search ThermoFisher Antibodies for MYL4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYL4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MYL4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MYL4
    Customized:
     lentivirus for stable overexpression of MYL4
     lentivirus expression plasmids for stable overexpression of MYL4
     adenovirus for overexpression of MYL4
     LSBio Antibodies in human, mouse, rat for MYL4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MYL4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4