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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MYL4 Gene

protein-coding GIFtS: 63
GCID: GC17P045286

myosin, light chain 4, alkali; atrial, embryonic

(Previous names: myosin, light polypeptide 4, alkali; atrial, embryonic...)

Explore 8 diseases affiliated with
MYL4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Myosin, Light Chain 4, Alkali; Atrial, Embryonic¹ ²		Myosin Light Chain Alkali GT-1 Isoform² ³
ALC1¹ ²		PRO1957¹
AMLC¹ ²		Myosin Light Chain 4²
GT1¹ ²		Myosin, Atrial/Fetal Muscle, Light Chain²
Myosin, Light Polypeptide 4, Alkali; Atrial, Embryonic¹ ²		MLC1³
Myosin Light Chain 1, Embryonic Muscle/Atrial Isoform² ³

External Ids:	HGNC: 7585¹	Entrez Gene: 4635²	Ensembl: ENSG00000198336⁷	OMIM: 160770⁵	UniProtKB: P12829³

Export aliases for MYL4 gene to outside databases

Previous GC identifers: GC17P044784 GC17P047685 GC17P045619 GC17P045761 GC17P042641 GC17P040664

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYL4:

Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable

myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali

light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding

the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MYL4_HUMAN, P12829

Function: Regulatory light chain of myosin. Does not bind calcium

summary for MYL4:

Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding

and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),

almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain

that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts

with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory

myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.

Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is

involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a

contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by

intracellular Ca2+ concentrations.

Gene Wiki entry for MYL4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MYL4 gene promoter:
GATA-3 NF-kappaB2 Zic1 RelA NF-kappaB1 NF-kappaB Zic3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MYL4 promoter sequence

Search SABiosciences Chromatin IP Primers for MYL4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYL4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21-qter Ensembl cytogenetic band: 17q21.32 HGNC cytogenetic band: 17q21-qter

MYL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL4 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P045286: view genomic region (about GC identifiers)

Start:	45,277,812 bp from pter	End:	45,301,045 bp from pter
Size:	23,234 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MYL4_HUMAN, P12829 (See protein sequence)

Recommended Name: Myosin light chain 4

Size: 197 amino acids; 21565 Da

Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains

Secondary accessions: D3DXJ7 P11783

Explore the universe of human proteins at neXtProt for MYL4: NX_P12829

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P12829

MYL4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001002841.1 NP_002467.1

ENSEMBL proteins:

ENSP00000459035 ENSP00000461570 ENSP00000458194 ENSP00000458907 ENSP00000442375

ENSP00000460734 ENSP00000377096 ENSP00000461747 ENSP00000461121 ENSP00000347055

Reactome Protein details: P12829
Human Recombinant Protein Products:

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	Novus Biologicals MYL4 Proteins Novus Biologicals MYL4 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for MYL4
	Uscn Proteins for MYL4

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0005859	muscle myosin complex	NAS	--
GO:0031672	A band	IMP	14985854

MYL4 for ontologies About GeneDecksing

MYL4 Antibody Products:

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Assay Products for MYL4:

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	Uscn ELISAs and CLIAs for MYL4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MYL4 for domains About GeneDecksing

2 InterPro domains/families:

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

Graphical View of Domain Structure for InterPro Entry P12829

ProtoNet protein and cluster: P12829

UniProtKB/Swiss-Prot: MYL4_HUMAN, P12829

Similarity: Contains 3 EF-hand domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MYL4_HUMAN, P12829

Function: Regulatory light chain of myosin. Does not bind calcium

Genatlas biochemistry entry for MYL4:

myosin,light polypeptide 4,alkali,atrial,skeletal,embryonic,same as MLC1-A & MLC1-EMB

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MYL4 Browse MicroRNA Expression Plasmids
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYL4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MYL4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL4

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003785	actin monomer binding	IDA	9180271
GO:0005509	calcium ion binding	IEA	--
GO:0008307	structural constituent of muscle	NAS	--
GO:0032038	myosin II heavy chain binding	NAS	16675844
GO:0051015	actin filament binding	IMP	9738905

MYL4 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MYL4:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_Integrin-mediated cell adhesion and migration

	Cell adhesion_Integrin-mediated cell adhesion and migration	1.00			Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases	0.49
	Cell adhesion Integrin-mediated cell adhesion and migration	1.00			Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases	0.49

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

Immune response _CCR3 signaling in eosinophils

	Immune response _CCR3 signaling in eosinophils	1.00			Inhibitory action of Lipoxins on neutrophil migration	0.51
	Immune response CCR3 signaling in eosinophils	1.00

PAK Pathway

	PAK Pathway	1.00			Epithelial Adherens Junctions	0.36
	Antioxidant Action of Vitamin-C	0.56

Striated Muscle Contraction

	Striated Muscle Contraction	1.00			Muscle contraction	0.65
	Striated Muscle Contraction	0.87

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 EMD Millipore Pathways for MYL4 (see all 7)

	Cell adhesion Integrin-mediated cell adhesion and migration
	Cell adhesion Tight junctions
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
	Immune response CCR3 signaling in eosinophils

5/16 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYL4 (see all 16)

	Activation of PKA through GPCR
	RhoA Pathway
	PKA Signaling
	Guidance Cues and Growth Cone Motility
	Antioxidant Action of Vitamin-C

5/8 GeneGo (Thomson Reuters) Pathways for MYL4 (see all 8)

	Signal transduction Activation of PKC via G-Protein coupled receptor
	Cell adhesion Integrin-mediated cell adhesion and migration
	Inhibitory action of Lipoxins on neutrophil migration
	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
	Immune response CCR3 signaling in eosinophils

2 BioSystems Pathways for MYL4

	Myometrial Relaxation and Contraction Pathways
	Striated Muscle Contraction

2 Reactome Pathways for MYL4

	Muscle contraction
	Striated Muscle Contraction

MYL4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MYL4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/49 Interacting proteins for MYL4 (P12829³ ENSP00000347055⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 49)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALB	P02768³, ENSP00000295897⁴	I2D: score=1 STRING: ENSP00000295897
SLC2A4	P14672³	I2D: score=1
ACTN2	ENSP00000355537⁴	STRING: ENSP00000355537
DES	ENSP00000363071⁴	STRING: ENSP00000363071
DMD	ENSP00000354923⁴	STRING: ENSP00000354923

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002026	regulation of the force of heart contraction	IMP	16675844
GO:0007517	muscle organ development	NAS	--
GO:0030049	muscle filament sliding	TAS	--
GO:0032781	positive regulation of ATPase activity	IMP	9738905
GO:0060048	cardiac muscle contraction	IMP	14985854

MYL4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MYL4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for MYL4 available from Tocris Bioscience About this table

Compound	Action	CAS #
(R)-(+)-Blebbistatin	Selective inhibitor of myosin II. Inactive enantiomer of (�)-blebbistatin (Cat. No. 1760)	--
(S)-(-)-Blebbistatin	Selective inhibitor of myosin II. Active enantiomer of (�)-blebbistatin (Cat. No. 1760)	[856925-71-8]
(�)-Blebbistatin	Selective inhibitor of myosin II	[674289-55-5]

1 HMDB Compound for MYL4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

1 Novoseek chemical compound relationship for MYL4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
creatinine	11.1	4	8164150 (1), 8002273 (1), 8803720 (1)

Search CenterWatch for drugs/clinical trials and news about MYL4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MYL4 gene (2 alternative transcripts):

NM_001002841.1 NM_002476.2

Unigene Cluster for MYL4:

Myosin, light chain 4, alkali; atrial, embryonic

Hs.463300 [show with all ESTs]

Unigene Representative Sequence: BM919855

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000571981 ENST00000572316 ENST00000570772 ENST00000576874 ENST00000536623

ENST00000573747 ENST00000393450(uc002ilh.3) ENST00000572303 ENST00000570671

ENST00000354968(uc002ilg.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MYL4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYL4
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYL4

Additional cDNA sequence:

BC030228.1 M20641.1 M24121.1 M36172.1 X13955.1

8 DOTS entries:

DT.100775232 DT.40121324 DT.95371904 DT.100775236 DT.95371903 DT.91970157 DT.95351169 DT.95371898

24/127 AceView cDNA sequences (see all 127):

BQ636631 W25367 BI832777 NM_001002841 BU738574 BU736020 BC030228 NM_002476

AI630404 AI355715 N70584 N45243 BI835446 N75417 H64136 BU658814

AI038953 AA424610 M36172 AI160293 BU658678 H83944 AI140093 N80733

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MYL4 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	^	9
SP1:											-				-										-
SP2:															-										-
SP3:															-
SP4:											-				-
SP5:

ECgene alternative splicing isoforms for MYL4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MYL4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAGGGTGAA

About this image

MYL4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/15 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 15)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Myocardium

Myocardium

Myocardium

Primitive Heart Tube Cells

Myocardium

Myocardium

Myocardium

Skeletal Muscle

Foregut Endoderm Cells

Endoderm

Heart

Cardiac Crescent

Cardiac Crescent Cells

Myocardium

Heart

Myocardium

Cardiac Fibroblasts

Epicardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10 LifeMap Cells

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Endoderm progenitor-like cells (Generation and expan...)

Definitive endoderm-like cells (Generation of mesend...)

Posterior foregut-like cells (A scalable, suspensi...)

DKK1-induced cells (Derivation of cardio...)

Cardiomyocyte-like progenitor cells (Derivation of cardio...)

See MYL4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MYL4

SOURCE GeneReport for Unigene cluster: Hs.463300

SABiosciences Custom PCR Arrays for MYL4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYL4 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYL4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MYL4 gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MYL4¹	myosin, light chain 4, alkali; atrial, embryonic	79.46(n) 84.86(a)		396472 XM_003642780.1 XP_003642828.1
African clawed frog (Xenopus laevis)	Amphibia	BX850142.1²	--	78.57(n)		BX850142.1
zebrafish (Danio rerio)	Actinopterygii	cmlc1¹	cardiac myosin light chain-1	70.07(n) 75.51(a)		64671 NM_131692.1 NP_571767.1
fruit fly (Drosophila melanogaster)	Insecta	Mlc-c³	myosin ATPase	53(a)		5A8 --
worm (Caenorhabditis elegans)	Secernentea	T12D8.6³	EF hand	46(a)		III(13694513-13695376) --
rice (Oryza sativa)	Liliopsida	--	OsCML9 - Calmodulin-related calcium sensor protein...	28(a)	possible ortholog	5(24067532-24068539)

ENSEMBL Gene Tree for MYL4 (if available)
TreeFam Gene Tree for MYL4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MYL4 gene

MYL6B² MYL1² MYL6² MYL3²

11 SIMAP similar genes for MYL4 using alignment to 6 protein entries: MYL4_HUMAN (see all proteins):

MYL6 MYL3 MYL1 CALM3 MYL6B CALM1

CALML3 CALM2 CALML4 TNNC2 TNNC1

MYL4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73327187^1,2	C,	--	45284489(+)	`CAAAGG/TAGCCA`	1	--	us2k¹		2		WA	120
rs143691626^1,2		--	45284643(+)	`AGGAGA/GAGCAG`	1	--	us2k¹		0	--	--	--	--
rs184614355^1,2		--	45284648(+)	`GAGCAA/GTGAAG`	1	--	us2k¹		0	--	--	--	--
rs73327190^1,2	C,	--	45284684(+)	`ACCCCA/GGGAAA`	1	--	us2k¹		2		WA	120
rs73327192^1,2	C,	--	45284745(+)	`AACTTC/AAACGT`	2	--	us2k¹		2		WA	120
rs9894365^1,2	C,F,A,H,	--	45284787(+)	`ACAGCA/GTGGGG`	2	--	us2k¹		22		NS EA NA WA CSA	2334
rs188686099^1,2		--	45284875(+)	`AATGGA/GCAGAT`	2	--	us2k¹		0	--	--	--	--
rs180764004^1,2		--	45284908(+)	`TTGCAC/GGCTTA`	2	--	us2k¹		0	--	--	--	--
rs116168810^1,2		--	45284963(+)	`TACAGG/ATGAGG`	2	--	us2k¹		1		WA	118
rs114619251^1,2	C,F,	--	45284993(+)	`GAAGTG/TATTTT`	2	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for MYL4 (45277812 - 45301045 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MYL4: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MYL4 for disorders           About GeneDecksing

OMIM gene information: 160770    OMIM disorders: --

8 diseases for MYL4:    About MalaCards

myocardial infarction acute myocardial infarction herpes gestationis scrapie

myopathy toxoplasmosis rhabdomyosarcoma myeloma

1 disease from the University of Copenhagen DISEASES database for MYL4:

Herpes gestationis

6 Novoseek disease relationships for MYL4 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ventricular aneurysm	77.9	3	7857308 (2)
aortic stenosis	48	2	1533180 (2)
congenital heart disease	40.4	3	8755658 (1), 16106982 (1), 14985854 (1)
acute myocardial infarction	23.3	2	8164150 (1)
myocardial infarction	10.8	4	8164150 (1), 1451244 (1), 7602751 (1)
infarct	5.44	4	7602751 (2), 8164150 (1)

Export disorders for MYL4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MYL4 gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with MYL4)

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world of online information

Molecular cloning and characterization of human atrial and ventricular myosin alkali light chain cDNA clones. (PubMed id 3417683)^{1, 2, 3} Kurabayashi M.... Yazaki Y. (1988)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The human embryonic myosin alkali light chain gene: use of alternative promoters and 3' non-coding regions. (PubMed id 2027757)^{1, 2} Rotter M.... Starzinski-Powitz A. (1991)
Heterogenic mRNAs with an identical protein-coding region of the human embryonic myosin alkali light chain in skeletal muscle cells. (PubMed id 2308163)^{1, 2} Zimmermann K....Starzinski-Powitz A. (1990)
Human embryonic/atrial myosin alkali light chain gene: characterization, sequence, and chromosomal location. (PubMed id 2129532)^{1, 2} Seharaseyon J.... Vanin E.F. (1990)
Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms. (PubMed id 2458299)^{1, 2} Seidel U.... Arnold H.H. (1988)
A novel human myosin alkali light chain is developmentally regulated. Expression in fetal cardiac and skeletal muscle and in adult atria. (PubMed id 2849544)^{1, 2} Arnold H.H.... Bober E. (1988)
Proteomic analysis of pharmacologically preconditioned cardiomyocytes reveals novel phosphorylation of myosin light chain 1. (PubMed id 11557734)^{1, 9} Arrell D.K....Van Eyk J.E. (2001)
Human atrial myosin light chain 1 expression attenuates heart failure. (PubMed id 16106982)^{1, 9} Abdelaziz A.I....Morano I. (2005)
Functional characterization of the human atrial essential myosin light chain (hALC-1) in a transgenic rat model. (PubMed id 14985854)^{1, 9} Abdelaziz A.I....Morano I. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4635	HGNC: 7585	AceView: MYL4	Ensembl:ENSG00000198336	euGenes: HUgn4635
ECgene: MYL4	H-InvDB: MYL4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MYL4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MYL4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MYL4 gene:
Search GeneIP for patents involving MYL4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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myosin, light chain 4, alkali; atrial, embryonic

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MYL4 Gene

myosin, light chain 4, alkali; atrial, embryonic

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