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MYL4 Gene

protein-coding   GIFtS: 65
GCID: GC17P045286

Myosin, Light Chain 4, Alkali; Atrial, Embryonic

(Previous names: myosin, light polypeptide 4, alkali; atrial, embryonic)
  See MYL4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin, Light Chain 4, Alkali; Atrial, Embryonic1 2     ALC12
Myosin, Light Polypeptide 4, Alkali; Atrial, Embryonic1 2     AMLC2
Myosin Light Chain 1, Embryonic Muscle/Atrial Isoform2 3     GT12
Myosin Light Chain Alkali GT-1 Isoform2 3     Myosin Light Chain 42
Atrial/Fetal Muscle1     Myosin, Atrial/Fetal Muscle, Light Chain2
Light Chain1     MLC13
myosin1     

External Ids:    HGNC: 75851   Entrez Gene: 46352   Ensembl: ENSG000001983367   OMIM: 1607705   UniProtKB: P128293   

Export aliases for MYL4 gene to outside databases

Previous GC identifers: GC17P044784 GC17P047685 GC17P045619 GC17P045761 GC17P042641 GC17P040664


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYL4 Gene:
Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two
nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This
gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively
spliced transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for MYL4 Gene:
MYL4 (myosin, light chain 4, alkali; atrial, embryonic) is a protein-coding gene. Diseases associated with MYL4 include herpes gestationis, and aortic valve disease. GO annotations related to this gene include structural constituent of muscle and calcium ion binding. An important paralog of this gene is MYL6B.

UniProtKB/Swiss-Prot: MYL4_HUMAN, P12829
Function: Regulatory light chain of myosin. Does not bind calcium

summary for MYL4 Gene:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYL4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYL4 gene promoter:
         GATA-3   NF-kappaB2   Zic1   RelA   NF-kappaB1   NF-kappaB   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYL4 promoter sequence
   Search Chromatin IP Primers for MYL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

MYL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P045286:  view genomic region     (about GC identifiers)

Start:
45,277,812 bp from pter      End:
45,301,045 bp from pter
Size:
23,234 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MYL4_HUMAN, P12829 (See protein sequence)
Recommended Name: Myosin light chain 4  
Size: 197 amino acids; 21565 Da
Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains
Secondary accessions: D3DXJ7 P11783

Explore the universe of human proteins at neXtProt for MYL4: NX_P12829

Explore proteomics data for MYL4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001002841.1  NP_002467.1  

    ENSEMBL proteins: 
     ENSP00000459035   ENSP00000461570   ENSP00000458194   ENSP00000458907   ENSP00000442375  
     ENSP00000460734   ENSP00000377096   ENSP00000461747   ENSP00000461121   ENSP00000347055  
    Reactome Protein details: P12829

    MYL4 Human Recombinant Protein Products:

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    antibodies-online proteins for MYL4 (9 products) 

     
    antibodies-online peptides for MYL4

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    antibodies-online antibodies for MYL4 (21 products) 

    MYL4 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing
    MYL: Myosins / Light chain

    2 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom

    Graphical View of Domain Structure for InterPro Entry P12829

    ProtoNet protein and cluster: P12829

    UniProtKB/Swiss-Prot: MYL4_HUMAN, P12829
    Similarity: Contains 3 EF-hand domains


    Find genes that share domains with MYL4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYL4_HUMAN, P12829
    Function: Regulatory light chain of myosin. Does not bind calcium

         Genatlas biochemistry entry for MYL4:
    myosin,light polypeptide 4,alkali,atrial,skeletal,embryonic,same as MLC1-A & MLC1-EMB

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003785actin monomer binding IDA9180271
    GO:0005509calcium ion binding IEA--
    GO:0008307structural constituent of muscle ----
    GO:0032038myosin II heavy chain binding NAS16675844
    GO:0051015actin filament binding IMP9738905
         
    Find genes that share ontologies with MYL4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MYL4:
     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MYL4

    miRNA
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    miRTarBase miRNAs that target MYL4:
    hsa-mir-335-5p (MIRT017034)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus2
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005859muscle myosin complex ----
    GO:0016459myosin complex IEA--
    GO:0031672A band IMP14985854

    Find genes that share ontologies with MYL4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYL4 About   (see all 17)  
    See pathways by source

    SuperPathContained pathways About
    1Striated Muscle Contraction
    Striated Muscle Contraction0.82
    Muscle contraction0.61
    Striated Muscle Contraction0.82
    2Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    3Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    4Cell adhesion Integrin mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Development MAG dependent inhibition of neurite outgrowth0.46
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cell adhesion Tight junctions0.33
    5PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56


    Find genes that share SuperPaths with MYL4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYL4 (see all 16)
        Activation of PKA through GPCR
    RhoA Pathway
    PKA Signaling
    Guidance Cues and Growth Cone Motility
    Antioxidant Action of Vitamin-C

    Selected GeneGo (Thomson Reuters) Pathways for MYL4 (see all 8)
        Signal transduction Activation of PKC via G-Protein coupled receptor
    Cell adhesion Integrin-mediated cell adhesion and migration
    Inhibitory action of Lipoxins on neutrophil migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils

    2 BioSystems Pathways for MYL4
        Myometrial Relaxation and Contraction Pathways
    Striated Muscle Contraction

    1 Reactome Pathway for MYL4
        Striated Muscle Contraction


    2 Kegg Pathways  (Kegg details for MYL4):
        Cardiac muscle contraction
    Adrenergic signaling in cardiomyocytes

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYL4
    Interactions:

        Search GeneGlobe Interaction Network for MYL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYL4 (P128293 ENSP000003470554) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    SLC2A4P146723I2D: score=1 
    ACTN2ENSP000003555374STRING: ENSP00000355537
    DESENSP000003630714STRING: ENSP00000363071
    DMDENSP000003549234STRING: ENSP00000354923
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002026regulation of the force of heart contraction IMP16675844
    GO:0007517muscle organ development ----
    GO:0030049muscle filament sliding TAS--
    GO:0032781positive regulation of ATPase activity IMP9738905
    GO:0060048cardiac muscle contraction IMP14985854

    Find genes that share ontologies with MYL4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MYL4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BTSSelective inhibitor of skeletal muscle myosin II ATPase activity[1576-37-0]
    (R)-(+)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)[1177356-70-5]
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)[856925-71-8]
    (+-)-BlebbistatinSelective inhibitor of myosin II ATPase activity[674289-55-5]

    1 HMDB Compound for MYL4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for MYL4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatinine 11.1 4 8164150 (1), 8002273 (1), 8803720 (1)



    Find genes that share compounds with MYL4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYL4 gene (2 alternative transcripts): 
    NM_001002841.1  NM_002476.2  

    Unigene Cluster for MYL4:

    Myosin, light chain 4, alkali; atrial, embryonic
    Hs.463300  [show with all ESTs]
    Unigene Representative Sequence: BM919855
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000571981 ENST00000572316 ENST00000570772 ENST00000576874 ENST00000536623
    ENST00000573747 ENST00000393450(uc002ilh.3) ENST00000572303 ENST00000570671
    ENST00000354968(uc002ilg.3)
    miRNA
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    Additional mRNA sequence: 

    BC030228.1 M20641.1 M24121.1 M36172.1 X13955.1 

    8 DOTS entries:

    DT.100775232  DT.40121324  DT.95371904  DT.100775236  DT.95371903  DT.91970157  DT.95351169  DT.95371898 

    Selected AceView cDNA sequences (see all 127):

    W25367 BI835446 N75417 NM_002476 BU738574 N45243 H64136 AI630404 
    N70584 BU736020 NM_001002841 BQ636631 BC030228 AI355715 BI832777 AI160293 
    N75003 BU658678 T28197 BQ058045 AI038953 BM697749 N80733 AI140093 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MYL4 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9
    SP1:                                -           -                             -         
    SP2:                                            -                             -         
    SP3:                                            -                                       
    SP4:                                -           -                                       
    SP5:                                                                                    


    ECgene alternative splicing isoforms for MYL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGGGTGAA
    MYL4 Expression
    About this image


    MYL4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 11 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
             Cardiomyocyte-like cells
     
     Skeletal Muscle (Muscoskeletal System)
             Multinuclear Myocyte Extraocular Muscles
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod
     
     NULL (Uncategorized)    fully expand to see all 3 entries
             Definitive endoderm-like cells
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Long Bone
    MYL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYL4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.463300
        Custom PCR Arrays for MYL4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYL4 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myl41 , 5 myosin, light polypeptide 41, 5 89.94(n)1
    95.6(a)1
      11 (67.79 cM)5
    178961  NM_010858.41  NP_034988.21 
     1045506635 
    chicken
    (Gallus gallus)
    Aves MYL41 myosin, light chain 4, alkali; atrial, embryonic 80.92(n)
    88.05(a)
      396472  XM_003642780.2  XP_003642828.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYL46
    myosin, light chain 4, alkali; atrial, embryonic
    85(a)
    1 ↔ 1
    6(67285088-67297824)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX850142.12   -- 78.57(n)    BX850142.1 
    zebrafish
    (Danio rerio)
    Actinopterygii myl41 myosin, light chain 4, alkali; atrial, embryonic 73.17(n)
    83.02(a)
      574004  NM_001025183.1  NP_001020354.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mlc-c3 myosin ATPase 53(a)   5A8   --
    worm
    (Caenorhabditis elegans)
    Secernentea T12D8.63 EF hand 46(a)   III(13694513-13695376)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MLC16
    Essential light chain for Myo1p, light chain for M...
    36(a)
    1 → many
    VII(306560-307009) YGL106W


    ENSEMBL Gene Tree for MYL4 (if available)
    TreeFam Gene Tree for MYL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYL4 gene
    MYL6B2  MYL12  MYL62  MYL32  
    11 SIMAP similar genes for MYL4 using alignment to 6 protein entries:     MYL4_HUMAN (see all proteins):
    MYL6    MYL3    MYL1    CALM2    CALM3    CALM1
    MYL6B    CALML3    CALML4    TNNC2    TNNC1

    Find genes that share paralogs with MYL4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYL4 (see all 393)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs733271871,2
    C,F--45284489(+) CAAAGG/TAGCCA 1 -- us2k12Minor allele frequency- T:0.10WA 120
    rs1436916261,2
    --45284643(+) AGGAGA/GAGCAG 1 -- us2k10--------
    rs1846143551,2
    --45284648(+) GAGCAA/GTGAAG 1 -- us2k10--------
    rs733271901,2
    C,F--45284684(+) ACCCCA/GGGAAA 1 -- us2k12Minor allele frequency- G:0.10WA 120
    rs733271921,2
    C,F--45284745(+) AACTTC/AAACGT 2 -- us2k12Minor allele frequency- A:0.10WA 120
    rs98943651,2
    C,F,A,H--45284787(+) ACAGCA/GTGGGG 2 -- us2k122Minor allele frequency- G:0.48NS EA NA WA CSA 2334
    rs1886860991,2
    --45284875(+) AATGGA/GCAGAT 2 -- us2k10--------
    rs1807640041,2
    --45284908(+) TTGCAC/GGCTTA 2 -- us2k10--------
    rs1161688101,2
    F--45284963(+) TACAGG/ATGAGG 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1146192511,2
    C,F--45284993(+) GAAGTG/TATTTT 2 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for MYL4 (45277812 - 45301045 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MYL4: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYL4
    DNA2.0 Custom Variant and Variant Library Synthesis for MYL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 160770    OMIM disorders: --

    3 diseases for MYL4:    
    About MalaCards
    herpes gestationis    aortic valve disease    myocardial infarction

    1 disease from the University of Copenhagen DISEASES database for MYL4:
    Herpes gestationis

    Find genes that share disorders with MYL4           About GenesLikeMe

    6 Novoseek inferred disease relationships for MYL4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ventricular aneurysm 77.9 3 7857308 (2)
    aortic stenosis 48 2 1533180 (2)
    congenital heart disease 40.4 3 8755658 (1), 16106982 (1), 14985854 (1)
    acute myocardial infarction 23.3 2 8164150 (1)
    myocardial infarction 10.8 4 8164150 (1), 1451244 (1), 7602751 (1)
    infarct 5.44 4 7602751 (2), 8164150 (1)

    Genetic Association Database (GAD): MYL4

    Export disorders for MYL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYL4 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with MYL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human atrial and ventricular myosin alkali light chain cDNA clones. (PubMed id 3417683)1, 2, 3 Kurabayashi M.... Yazaki Y. (J. Biol. Chem. 1988)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The human embryonic myosin alkali light chain gene: use of alternative promoters and 3' non-coding regions. (PubMed id 2027757)1, 2 Rotter M.... Starzinski-Powitz A. (Nucleic Acids Res. 1991)
    4. Heterogenic mRNAs with an identical protein-coding region of the human embryonic myosin alkali light chain in skeletal muscle cells. (PubMed id 2308163)1, 2 Zimmermann K....Starzinski-Powitz A. (J. Mol. Biol. 1990)
    5. Human embryonic/atrial myosin alkali light chain gene: characterization, sequence, and chromosomal location. (PubMed id 2129532)1, 2 Seharaseyon J.... Vanin E.F. (Genomics 1990)
    6. Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms. (PubMed id 2458299)1, 2 Seidel U.... Arnold H.H. (Gene 1988)
    7. A novel human myosin alkali light chain is developmentally regulated. Expression in fetal cardiac and skeletal muscle and in adult atria. (PubMed id 2849544)1, 2 Arnold H.H.... Bober E. (Eur. J. Biochem. 1988)
    8. Proteomic analysis of pharmacologically preconditioned cardiomyocytes reveals novel phosphorylation of myosin light chain 1. (PubMed id 11557734)1, 9 Arrell D.K....Van Eyk J.E. (Circ. Res. 2001)
    9. Human atrial myosin light chain 1 expression attenuates heart failure. (PubMed id 16106982)1, 9 Abdelaziz A.I....Morano I. (Adv. Exp. Med. Biol. 2005)
    10. Functional characterization of the human atrial essential myosin light chain (hALC-1) in a transgenic rat model. (PubMed id 14985854)1, 9 Abdelaziz A.I....Morano I. (J. Mol. Med. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4635 HGNC: 7585 AceView: MYL4 Ensembl:ENSG00000198336 euGenes: HUgn4635
    ECgene: MYL4 Kegg: 4635 H-InvDB: MYL4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYL4 gene:
    Search GeneIP for patents involving MYL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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