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MYL3 Gene

protein-coding GIFtS: 69

GC03M046874

myosin, light chain 3, alkali; ventricular, skeletal, slow
(Previous names: myosin, light polypeptide 3, alkali; ventricular, skeletal, slow )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CMH8 ^¹, ², ⁵
CMLC1 ^³
MLC1SB ^¹, ², ³
MLC1V ^¹, ²
OTTHUMP00000165922 ^²
VLC1 ^¹, ²

Descriptions
Cardiac myosin light chain-1 ^³
Myosin light chain 1, slow-twitch muscle B/ventricular isoform ^³
Ventricular/slow twitch myosin alkali light chain ^³
myosin, light chain 3, alkali; ventricular, skeletal, slow ^²
myosin, light polypeptide 3, alkali; ventricular, skeletal, slow ^¹, ²
slow skeletal ventricular myosin alkali light chain 3 ^²

External Ids
HGNC: 7584¹
Entrez Gene: 4634²
UniProtKB: P08590³
Ensembl: ENSG00000160808⁷

Search outside databases for aliases for MYL3 gene

Previous GC identifers: GC03P046253 GC03P046130 GC03M046696 GC03M046859

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for MYL3:

MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both

the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been

identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided

by RefSeq]

UniProtKB/Swiss-Prot: MYL3_HUMAN, P08590

Function: Regulatory light chain of myosin. Does not bind calcium

Gene Wiki entry for MYL3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MYL3 gene

Entrez Gene cytogenetic band: 3p21.3-p21.2 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p

MYL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M046874: (about GC identifiers)

Start:	46,874,361 bp from pter
End:	46,879,977 bp from pter
Size:	5,617 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MYL3_HUMAN, P08590 (See protein sequence)

Recommended Name: Myosin light chain 3

Size: 195 amino acids; 21932 Da

Subunit: Myosin is an hexamer of 2 heavy chains and 4 light chains

Secondary accessions: Q9NRS8

Post-translational modifications:

The N-terminus is blocked¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000249.1

ENSEMBL proteins:

ENSP00000379210 ENSP00000292327

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Myosin light chain 3, Slow skeletal Myosin)
	Human Recombinant Proteins from Abnova (MYL3)

OriGene Purified Recombinant Human Protein: MYL3

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005859	muscle myosin complex	TAS	2789520
GO:0016459	myosin complex	IEA	--
GO:0031672	A band	IDA	16675844
GO:0031674	I band	IDA	16675844

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Antibodies for MYL3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for MYL3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Myosin light chain 3, Slow skeletal Myosin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MYL3)
	Novus Biologicals Antibodies for MYL3

Assays for MYL3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P08590

ProtoNet protein and cluster: P08590

UniProtKB/Swiss-Prot: MYL3_HUMAN, P08590

Similarity: Contains 3 EF-hand domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MYL3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MYL3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000258

Applied Biosystems Silencer® siRNAs for MYL3

Sigma-Aldrich siRNA and siRNA Panels for MYL3

Sigma-Aldrich shRNA for MYL3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MYL3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000258
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000258
untagged cDNA clone in CMV expression vector: NM_000258

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000258

UniProtKB/Swiss-Prot: MYL3_HUMAN, P08590

Function: Regulatory light chain of myosin. Does not bind calcium

Genatlas biochemistry entry for MYL3:

myosin,light polypeptide 3,alkali,essential,ventricular,skeletal,slow,same as MLC1-SB & MLC1-V

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003774	motor activity	IEA	--
GO:0003785	actin monomer binding	IDA	16675844
GO:0005509	calcium ion binding	IEA	--
GO:0008307	structural constituent of muscle	TAS	2789520
GO:0032038	myosin II heavy chain binding	NAS	16675844

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/10 Sigma-Aldrich "Your Favorite Gene" Pathways for MYL3 (Your Favorite Gene powered by Ingenuity) (see all 10 )

Regulation of Actin-based Motility by Rho
Calcium Signaling
CXCR4 Signaling
Thrombin Signaling
Cardiac Hypertrophy Signaling

GeneDecks MYL3 for the pathways selected above

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5/44 Interacting proteins for MYL3 (P08590² ENSP00000292327³) via UniProtKB, MINT, and/or STRING (see all 44 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MYBPC3	ENSP00000256993³	STRING (score=.983)
TNNT2	ENSP00000356286³	STRING (score=.981)
TNNI3	ENSP00000341838³	STRING (score=.98)
TPM1	ENSP00000350667³	STRING (score=.979)
MYBPC1	ENSP00000354849³	STRING (score=.96)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002026	regulation of the force of heart contraction	IMP	16675844
GO:0006942	regulation of striated muscle contraction	IMP	16675844
GO:0032781	positive regulation of ATPase activity	ISS	16675844
GO:0055010	ventricular cardiac muscle morphogenesis	IMP	8673105 16754800
GO:0060048	cardiac muscle contraction	IMP	16675844

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for MYL3 available from Tocris Bioscience

Compound	Action	CAS number
(�)-Blebbistatin	Selective inhibitor of myosin II	[674289-55-5]

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MYL3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MYL3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000258

Sigma-Aldrich siRNA and siRNA Panels for MYL3

Sigma-Aldrich shRNA for MYL3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000258

REFSEQ mRNAs for MYL3 gene:

NM_000258.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000258

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000258
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000258
                                 untagged cDNA clone in CMV expression vector: NM_000258

Additional cDNA sequence:

AF174483.1 AK312044.1 BC009790.1 M24122.1 X07373.1

9 DOTS entries:

DT.319748 DT.101985513 DT.101985514 DT.92422207 DT.100814176 DT.92422204 DT.95338064 DT.100814172

DT.92422209

24/425 AceView cDNA sequences (see all 425 ):

C05510 BX500406 AJ573065 AI370949 C05582 AJ573201 AJ708945 F31045

C05498 C05446 F30807 AJ572719 AJ706808 C05527 F36131 F23440

AI313433 AA346021 F25471 F25146 F26941 BC009790 AA176823 C05486

highest scoring ESTs for MYL3:

M24122 AA092797 AA093113 AA247261 AA248238 AA248641 AA248731 AA249211 AA314109 AA346021

Unigene Cluster for MYL3:

Myosin, light chain 3, alkali; ventricular, skeletal, slow

Hs.517939 [show with all ESTs]

Unigene Representative Sequence: BC009790

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for MYL3

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c
SP1:
SP2:
SP3:

About this scheme

ECgene alternative splicing isoforms for MYL3

2 Ensembl transcripts including schematic representations:

ENST00000395869 ENST00000292327

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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MYL3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MYL3

¹ / ² / ³

5 probe-sets matching MYL3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41730_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.85	M24122	1.00	1.00	1.00	1
41731_g_at²^{, 3}	U95-A	2	1.00	0.97	1.00	0.96	M24122	1.00	1.00	1.00	1
55609_at²^{, 3}	U95-C	2	1.00	0.97	1.00	1.20	F22666	0.80	1.00	0.91	1
205589_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000258	0.60	1.00	0.82	1
205589_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks MYL3 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.517939
Expression variation in blood from EXPOLDB for MYL3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MYL3 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MYL3¹	--	myosin, light chain 3, alkali; ventricular, skeletal, more	88.72(n) 94.87(a)	476644 XM_533849.2 XP_533849.1
cow (Bos taurus)	MYL3¹	--	myosin, light chain 3, alkali; ventricular, skeletal, more	87.06(n) 87.65(a)	618352 NM_001076501.1 NP_001069969.1
rat (Rattus norvegicus)	Myl3¹	--	myosin, light chain 3, alkali; ventricular, skeletal, more	89.23(n) 95.9(a)	24585 NM_012606.1 NP_036738.1
mouse (Mus musculus)	Myl3^{1, 5}	9 (61.00 cM)⁵	myosin, light polypeptide 3^{1, 5}	90.94(n)¹ 95.9(a)¹	17897¹ NM_010859.2¹ NP_034989.1¹ AI449858⁵ AK002312⁵ (see all 11)
chicken (Gallus gallus)	MYL3¹	--	myosin, light chain 3, alkali; ventricular, skeletal, more	75.52(n) 82.81(a)	396067 NM_205159.1 NP_990490.1

About this table Species with no ortholog for MYL3

ENSEMBL Gene Tree for MYL3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MYL3 gene

MYL4² MYL1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/40 NCBI SNPs in MYL3 are shown (see all 40 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 37)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs7633581^1,2	A,C,F,H	46881597(+)	`TGGCAC/TGCCCT`	1	--	ng3¹		4	EU EA WA	414
	rs1042973^1,2	C,F,H	46874520(-)	`CGTGGG/AAAGGA`	1	--	ut3¹ trp³		6	EA MN EU WA	2098
	rs880154^1,2	C,F,O	46880589(-)	`agataC/Tggagc`	1	--	ng3¹		3	NA	142
	rs880155^1,2	F,H	46880422(-)	`GACTTC/ACGCCT`	1	--	ng3¹		4	EU EA WA	414
	rs2233263^1,2	F,H	46880261(-)	`CTTACG/AGACCT`	1	--	ng3¹		4	EU EA WA	420
	rs2233264^1,2	C	46879816(-)	`GCTCCC/TGCACC`	1	P/P	syn¹ ese³		4	EA MN NA	2784
	rs3792558^1,2	A,C,F,H	46878098(+)	`CTGTCC/TGTAGG`	1	--	int¹		17	EA NA EU WA	2956
	rs2227294^1,2	A,C,F,H	46877133(-)	`TTAGTA/CCCGGG`	1	--	int¹		13	EA NA EU WA	2308
	rs1531136^1,2	A,C,F,H	46876658(+)	`tgttaC/Tgtcac`	1	--	int¹		7	EU EA WA NA	562
	rs936175^1,2	A,C,F,H	46879712(+)	`CCACTC/AACTTG`	1	--	int¹		11	EU EA WA MN NA	1080

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HapMap Linkage Disequilibrium images for MYL3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 160790 disorders: 608751

UniProtKB/Swiss-Prot: MYL3_HUMAN, P08590

Defects in MYL3 are the cause of cardiomyopathy familial hypertrophic type 8 (CMH8)

[MIM:608751]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by

ventricular hypertrophy, which is usually asymmetric and often involves the interventricular

septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be

readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from

benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8

inheritance can be autosomal dominant or recessive

Defects in MYL3 are the cause of cardiomyopathy hypertrophic with mid-left ventricular

chamber type 1 (MVC1) [MIM:608751]. MVC1 is a very rare variant of familial hypertrophic

cardiomyopathy, characterized by mid-left ventricular chamber thickening

3 Novoseek disease relationships for MYL3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
acute myocardial infarction	50.54	3	8254402 (1), 7988046 (1), 7704948 (1)
myocardial infarction	28.58	1	8254402 (1)
renal failure	18.40	1	1507479 (1)

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GeneTests: MYL3

Familial Hypertrophic Cardiomyopathy

Human Gene Mutation Database: MYL3
Genetic Association Database: MYL3
Human Genome Epidemiology Navigator: MYL3 (7 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/42 PubMed articles for MYL3 gene (see all 42 ):

Systematic analysis of the regulatory and essential myosin light chain genes: genetic variants and mutations in hypertrophic cardiomyopathy. (PubMed id 12404107)^{1, 3, 6} Kabaeva Z.T.... Osterziel K.J. (2002)
Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling. (PubMed id 16199542)^{3, 6} Ingles J.... Semsarian C. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy. (PubMed id 12707239)^{3, 4} Richard P....Komajda M. (2003)
Myosin light chain mutation causes autosomal recessive cardiomyopathy with mid-cavitary hypertrophy and restrictive physiology. (PubMed id 12021217)^{3, 4} Olson T.M.... Driscoll D.J. (2002)
Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle. (PubMed id 8673105)^{3, 4} Poetter K.... Epstein N.D. (1996)
The major protein expression profile and two-dimensional protein database of human heart. (PubMed id 7498159)^{3, 4} Kovalyov L.I.... Musalyamov A.K. (1995)
Analysis of the upstream regulatory region of human ventricular myosin light chain 1 gene. (PubMed id 1479618)^{2, 3} Shi Q.... Jackowski G. (1992)
Chromosomal assignment of two myosin alkali light-chain genes encoding the ventricular/slow skeletal muscle isoform and the atrial/fetal muscle isoform (MYL3, MYL4). (PubMed id 2784124)^{2, 3} Cohen-Haguenauer O....Frezal J. (1989)
Human ventricular/slow twitch myosin alkali light chain gene characterization, sequence, and chromosomal location. (PubMed id 2789520)^{3, 4} Fodor W.L....Vanin E.F. (1989)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4634	HGNC: 7584	AceView: MYL3	Ensembl:ENSG00000160808	euGenes: HUgn4634
ECgene: MYL3	H-InvDB: MYL3

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MYL3	Genetics and Cytogenetics in Oncology and Haematology
Familial hypertrophic cardiomyopathy mutation database	http://www.angis.org.au/Databases/Heart/heartbreak.html
GeneReviews	http://www.genetests.org/query?gene=MYL3

Licensable Technologies for MYL3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for MYL3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MYL3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MYL3		Antibodies for MYL3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MYL3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MYL3)
	Antibodies (MYL3)
	Chimera RNAi (MYL3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Myosin light chain 3, Slow skeletal Myosin)
	Antibodies (Myosin light chain 3, Slow skeletal Myosin)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for MYL3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MYL3

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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MYL3 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for MYL3

Summaries
for MYL3

Genomic Location
for MYL3

Proteins
for MYL3

Protein Domains/
Families
for MYL3

Gene Function
for MYL3

Pathways & Interactions
for MYL3

Drugs & Compounds
for MYL3

Transcripts
for MYL3

Expression
for MYL3

Orthologs
for MYL3

Paralogs
for MYL3

SNPs/Variants
for MYL3

Disorders & Mutations
for MYL3

Medical News
for MYL3

Publications
for MYL3

Search for MYL3

Genome Databases showing MYL3

Other Databases showing MYL3

Specialized Databases showing MYL3

Licensable Technologies
for MYL3

Services
for MYL3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MYL3 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor MYL3

Summariesfor MYL3

Genomic Locationfor MYL3

Proteinsfor MYL3

Protein Domains/Familiesfor MYL3

Gene Functionfor MYL3

Pathways & Interactionsfor MYL3

Drugs & Compoundsfor MYL3

Transcriptsfor MYL3

Expression for MYL3

Orthologsfor MYL3

Paralogsfor MYL3

SNPs/Variantsfor MYL3

Disorders & Mutationsfor MYL3

Medical Newsfor MYL3

Publicationsfor MYL3

Search for MYL3

Genome Databases showing MYL3

Other Databases showing MYL3

Specialized Databases showing MYL3

Licensable Technologiesfor MYL3

Servicesfor MYL3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MYL3

Summaries
for MYL3

Genomic Location
for MYL3

Proteins
for MYL3

Protein Domains/
Families
for MYL3

Gene Function
for MYL3

Pathways & Interactions
for MYL3

Drugs & Compounds
for MYL3

Transcripts
for MYL3

Expression
for MYL3

Orthologs
for MYL3

Paralogs
for MYL3

SNPs/Variants
for MYL3

Disorders & Mutations
for MYL3

Medical News
for MYL3

Publications
for MYL3

Licensable Technologies
for MYL3

Services
for MYL3