Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MYL3 Gene

Aliases for MYL3 Gene

  • Myosin, Light Chain 3, Alkali; Ventricular, Skeletal, Slow 2 3
  • Myosin, Light Polypeptide 3, Alkali; Ventricular, Skeletal, Slow 2 3
  • Myosin Light Chain 1, Slow-Twitch Muscle B/Ventricular Isoform 3 4
  • Ventricular/Slow Twitch Myosin Alkali Light Chain 3 4
  • Cardiac Myosin Light Chain 1 3 4
  • MLC1SB 3 4
  • CMLC1 3 4
  • Myosin Light Chain 3 3
  • Ventricular 6
  • Skeletal 6
  • MLC1V 3
  • VLC1 3
  • CMH8 3
  • Slow 6

External Ids for MYL3 Gene

Previous GeneCards Identifiers for MYL3 Gene

  • GC03P046253
  • GC03P046130
  • GC03M046696
  • GC03M046859
  • GC03M046874

Summaries for MYL3 Gene

Entrez Gene Summary for MYL3 Gene

  • MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYL3 Gene

MYL3 (Myosin, Light Chain 3, Alkali; Ventricular, Skeletal, Slow) is a Protein Coding gene. Diseases associated with MYL3 include cardiomyopathy, familial hypertrophic, 8 and myl3-related familial hypertrophic cardiomyopathy. Among its related pathways are RhoGDI Pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include calcium ion binding and motor activity. An important paralog of this gene is MYL1.

UniProtKB/Swiss-Prot for MYL3 Gene

  • Regulatory light chain of myosin. Does not bind calcium

Tocris Summary for MYL3 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name), almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II. Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by intracellular Ca2+ concentrations.

Gene Wiki entry for MYL3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL3 Gene

Genomics for MYL3 Gene

Regulatory Elements for MYL3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MYL3 Gene

Start:
46,857,867 bp from pter
End:
46,882,169 bp from pter
Size:
24,303 bases
Orientation:
Minus strand

Genomic View for MYL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL3 Gene

Proteins for MYL3 Gene

  • Protein details for MYL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08590-MYL3_HUMAN
    Recommended name:
    Myosin light chain 3
    Protein Accession:
    P08590
    Secondary Accessions:
    • B2R534
    • Q9NRS8

    Protein attributes for MYL3 Gene

    Size:
    195 amino acids
    Molecular mass:
    21932 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains

neXtProt entry for MYL3 Gene

Proteomics data for MYL3 Gene at MOPED

Post-translational modifications for MYL3 Gene

Other Protein References for MYL3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MYL3 Gene

Domains for MYL3 Gene

Gene Families for MYL3 Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • MYL :Myosins / Light chain

Protein Domains for MYL3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYL3 Gene

Graphical View of Domain Structure for InterPro Entry

P08590

UniProtKB/Swiss-Prot:

MYL3_HUMAN :
  • P08590
Domain:
  • Contains 3 EF-hand domains.
genes like me logo Genes that share domains with MYL3: view

Function for MYL3 Gene

Molecular function for MYL3 Gene

GENATLAS Biochemistry:
myosin,light polypeptide 3,alkali,essential,ventricular,skeletal,slow,same as MLC1-SB & MLC1-V
UniProtKB/Swiss-Prot Function:
Regulatory light chain of myosin. Does not bind calcium

Gene Ontology (GO) - Molecular Function for MYL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003785 actin monomer binding IDA 16675844
GO:0005509 calcium ion binding IEA --
GO:0008307 structural constituent of muscle TAS 2789520
GO:0032038 myosin II heavy chain binding NAS 16675844
genes like me logo Genes that share ontologies with MYL3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYL3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MYL3 Gene

Localization for MYL3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYL3 Gene COMPARTMENTS Subcellular localization image for MYL3 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MYL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005859 muscle myosin complex TAS 2789520
GO:0016459 myosin complex --
GO:0030017 sarcomere TAS 16754800
GO:0031672 A band IDA 16675844
genes like me logo Genes that share ontologies with MYL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYL3 Gene

Pathways for MYL3 Gene

genes like me logo Genes that share pathways with MYL3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MYL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002026 regulation of the force of heart contraction IMP 16675844
GO:0006942 regulation of striated muscle contraction IMP 16675844
GO:0007519 skeletal muscle tissue development IEA --
GO:0008152 metabolic process IEA --
GO:0030049 muscle filament sliding TAS --
genes like me logo Genes that share ontologies with MYL3: view

Compounds for MYL3 Gene

(4) Tocris Compounds for MYL3 Gene

Compound Action Cas Number
(�)-Blebbistatin Selective inhibitor of myosin II ATPase activity [674289-55-5]
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (�)-blebbistatin (Cat. No. 1760) [1177356-70-5]
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (�)-blebbistatin (Cat. No. 1760) [856925-71-8]
BTS Selective inhibitor of skeletal muscle myosin II ATPase activity [1576-37-0]

(1) HMDB Compounds for MYL3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Novoseek inferred chemical compound relationships for MYL3 Gene

Compound -log(P) Hits PubMed IDs
creatinine 31.8 3
genes like me logo Genes that share compounds with MYL3: view

Transcripts for MYL3 Gene

mRNA/cDNA for MYL3 Gene

(425) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYL3 Gene

Myosin, light chain 3, alkali; ventricular, skeletal, slow:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYL3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYL3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1:
SP2:
SP3:

Relevant External Links for MYL3 Gene

GeneLoc Exon Structure for
MYL3
ECgene alternative splicing isoforms for
MYL3

Expression for MYL3 Gene

mRNA expression in normal human tissues for MYL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYL3 Gene

This gene is overexpressed in Heart - Left Ventricle (41.9) and Muscle - Skeletal (8.1).

Protein differential expression in normal tissues for MYL3 Gene

This gene is overexpressed in Heart (31.1), Esophagus (26.6), and Fetal heart (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYL3 Gene

SOURCE GeneReport for Unigene cluster for MYL3 Gene Hs.517939

genes like me logo Genes that share expressions with MYL3: view

Expression partners for MYL3 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MYL3 Gene

Orthologs for MYL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYL3 35
  • 91.82 (n)
  • 94.97 (a)
MYL3 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYL3 35
  • 89.06 (n)
  • 93.85 (a)
MYL3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myl3 35
  • 91.3 (n)
  • 96.27 (a)
Myl3 16
Myl3 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC460327 35
  • 98.4 (n)
  • 97.95 (a)
MYL3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myl3 35
  • 85.47 (n)
  • 89.23 (a)
oppossum
(Monodelphis domestica)
Mammalia MYL3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYL3 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYL3 35
  • 77.64 (n)
  • 85.71 (a)
MYL3 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYL3 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myl3 35
  • 71.49 (n)
  • 78.62 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc66286 35
zgc:66286 35
  • 74.79 (n)
  • 76.25 (a)
MYL3 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mlc-c 37
  • 48 (a)
Mlc-c 36
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T12D8.6 37
  • 46 (a)
mlc-3 36
  • 45 (a)
ManyToMany
mlc-5 36
  • 47 (a)
ManyToMany
mlc-6 36
  • 47 (a)
ManyToMany
mlc-7 36
  • 28 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MLC1 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.211 36
  • 57 (a)
ManyToMany
CSA.4806 36
  • 46 (a)
ManyToMany
CSA.6288 36
  • 47 (a)
ManyToMany
CSA.6678 36
  • 45 (a)
ManyToMany
Species with no ortholog for MYL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYL3 Gene

ENSEMBL:
Gene Tree for MYL3 (if available)
TreeFam:
Gene Tree for MYL3 (if available)

Paralogs for MYL3 Gene

Paralogs for MYL3 Gene

Selected SIMAP similar genes for MYL3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MYL3: view

Variants for MYL3 Gene

Sequence variations from dbSNP and Humsavar for MYL3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs880154 -- 46,864,095(-) agata(C/T)ggagc upstream-variant-2KB
rs880155 -- 46,863,928(-) GACTT(A/C)CGCCT upstream-variant-2KB
rs936175 -- 46,863,218(+) CCACT(A/C)ACTTG intron-variant
rs936176 -- 46,864,201(+) GTCTG(A/C/G/T)GGGTG upstream-variant-2KB
rs1042407 -- 46,863,414(-) CACAT(C/G)CCTCT utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MYL3 Gene

Variant ID Type Subtype PubMed ID
dgv1455e1 CNV Complex 17122850
nsv428417 CNV Loss 18775914
essv8614 CNV CNV 17122850
nsv508915 CNV Insertion 20534489
dgv5130n71 CNV Loss 21882294
nsv876754 CNV Gain 21882294
nsv876755 CNV Loss 21882294

Relevant External Links for MYL3 Gene

HapMap Linkage Disequilibrium report
MYL3
Human Gene Mutation Database (HGMD)
MYL3
Locus Specific Mutation Databases (LSDB)
MYL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYL3 Gene

Disorders for MYL3 Gene

(1) OMIM Diseases for MYL3 Gene (160790)

UniProtKB/Swiss-Prot

MYL3_HUMAN
  • Cardiomyopathy, familial hypertrophic 8 (CMH8) [MIM:608751]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Rarely, patients present a variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening. {ECO:0000269 PubMed:12021217, ECO:0000269 PubMed:12707239, ECO:0000269 PubMed:8673105}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for MYL3 Gene

(3) Novoseek inferred disease relationships for MYL3 Gene

Disease -log(P) Hits PubMed IDs
acute myocardial infarction 47.6 3
myocardial infarction 24.9 1
renal failure 14.9 1

Relevant External Links for MYL3

GeneTests
MYL3
GeneReviews
MYL3
Genetic Association Database (GAD)
MYL3
Human Genome Epidemiology (HuGE) Navigator
MYL3
genes like me logo Genes that share disorders with MYL3: view

No data available for Genatlas for MYL3 Gene

Publications for MYL3 Gene

  1. Systematic analysis of the regulatory and essential myosin light chain genes: genetic variants and mutations in hypertrophic cardiomyopathy. (PMID: 12404107) Kabaeva Z.T. … Osterziel K.J. (Eur. J. Hum. Genet. 2002) 3 23 48
  2. The role of sarcomere gene mutations in patients with idiopathic dilated cardiomyopathy. (PMID: 19293840) MA … ber L. (Eur. J. Hum. Genet. 2009) 3 23 48
  3. Minigenes encoding N-terminal domains of human cardiac myosin light chain-1 improve heart function of transgenic rats. (PMID: 16675844) Haase H. … Morano I. (FASEB J. 2006) 3 23
  4. Chromosomal assignment of two myosin alkali light-chain genes encoding the ventricular/slow skeletal muscle isoform and the atrial/fetal muscle isoform (MYL3, MYL4). (PMID: 2784124) Cohen-Haguenauer O. … FrAczal J. (Hum. Genet. 1989) 2 3
  5. Human ventricular/slow twitch myosin alkali light chain gene characterization, sequence, and chromosomal location. (PMID: 2789520) Fodor W.L. … Vanin E.F. (J. Biol. Chem. 1989) 3 4

Products for MYL3 Gene

Sources for MYL3 Gene

Back to Top

Content