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MYL2 Gene

protein-coding GIFtS: 71

GC12M109811

myosin, light chain 2, regulatory, cardiac, slow
(Previous names: myosin, light polypeptide 2, regulatory, cardiac, slow )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CMH10 ^¹, ², ⁵
DKFZp779C0562 ^²
MLC-2 ^³
MLC-2v ^³
MLC2 ^²

Descriptions
RLC of myosin ^²
cardiac ventricular myosin light chain 2 ^²
myosin light chain 2 ^²
myosin regulatory light chain 2, ventricular/cardiac muscle isoform ^²
myosin, light chain 2, regulatory, cardiac, slow ^²
myosin, light polypeptide 2, regulatory, cardiac, slow ^¹, ²
regulatory light chain of myosin ^²
slow cardiac myosin regulatory light chain 2 ^²

External Ids
HGNC: 7583¹
Entrez Gene: 4633²
UniProtKB: P10916³
Ensembl: ENSG00000111245⁷

Search outside databases for aliases for MYL2 gene

Previous GC identifers: GC12M110251 GC12M111026 GC12M111131 GC12M109760

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MYL2:

Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy

chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers

contraction. Mutations in this gene are associated with mid-left ventricular chamber type

hypertrophic cardiomyopathy. [provided by RefSeq]

Gene Wiki entry for MYL2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MYL2 gene

Entrez Gene cytogenetic band: 12q24.11 Ensembl cytogenetic band: 12q24.11 HGNC cytogenetic band: 12q24.11

MYL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M109811: (about GC identifiers)

Start:	109,833,009 bp from pter
End:	109,842,766 bp from pter
Size:	9,758 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_009775.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MLRV_HUMAN, P10916 (See protein sequence)

Recommended Name: Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

Size: 166 amino acids; 18789 Da

Subunit: Myosin is an hexamer of 2 heavy chains and 4 light chains

Miscellaneous: This chain binds calcium

Secondary accessions: Q16123

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000423.2

ENSEMBL proteins:

ENSP00000228841

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Myosin Light Chain 2, Myosin light chain hHS-M21 phosphatase)
	Human Recombinant Proteins from Abnova (MYL2)

OriGene Purified Recombinant Human Protein: MYL2

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016459	myosin complex	IEA	--
GO:0030017	sarcomere	TAS	16754800

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Antibodies for MYL2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for MYL2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Myosin Light Chain 2, Myosin light chain hHS-M21 phosphatase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MYL2)
	Novus Biologicals Antibodies for MYL2

Assays for MYL2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P10916

ProtoNet protein and cluster: P10916

UniProtKB/Swiss-Prot: MLRV_HUMAN, P10916

Similarity: Contains 3 EF-hand domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MYL2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MYL2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC015821

Applied Biosystems Silencer® siRNAs for MYL2

Sigma-Aldrich siRNA for MYL2

Sigma-Aldrich shRNA for MYL2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MYL2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000432
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000432
untagged cDNA clones in CMV expression vector (see all 2): BC015821

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000432

Genatlas biochemistry entry for MYL2:

myosin,light polypeptide 2,regulatory,cardiac,slow

11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Myl2):

	embryogenesis	growth/size	homeostasis/metabolism	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system	muscle	normal
respiratory system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003774	motor activity	IEA	--
GO:0003785	actin monomer binding	IDA	9180271
GO:0005509	calcium ion binding	IDA	11102452
GO:0005515	protein binding	IPI	16555005
GO:0008307	structural constituent of muscle	TAS	8673105

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/15 Sigma-Aldrich "Your Favorite Gene" Pathways for MYL2 (Your Favorite Gene powered by Ingenuity) (see all 15 )

Axonal Guidance Signaling
Hepatic Fibrosis / Hepatic Stellate Cell Activation
CXCR4 Signaling
IL-8 Signaling
Regulation of Actin-based Motility by Rho

GeneDecks MYL2 for the pathways selected above

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5/69 Interacting proteins for MYL2 (ENSP00000228841³ P10916^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 69 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
USP6	P35125-3¹	EBI-725770, EBI-954590
LRSAM1	Q6UWE0²	MINT-64679
MYBPC3	ENSP00000256993³	STRING (score=.985)
TNNT2	ENSP00000356286³	STRING (score=.984)
TPM1	ENSP00000350667³	STRING (score=.984)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006942	regulation of striated muscle contraction	TAS	8673105
GO:0030308	negative regulation of cell growth	IMP	15824735
GO:0055003	cardiac myofibril assembly	ISS	--
GO:0055010	ventricular cardiac muscle morphogenesis	IMP	8673105
GO:0060047	heart contraction	ISS	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for MYL2 available from Tocris Bioscience

Compound	Action	CAS number
(�)-Blebbistatin	Selective inhibitor of myosin II	[674289-55-5]

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2 Novoseek chemical compound relationships for MYL2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
potassium	0.00	1	15753841 (1)
calcium	0.00	1	15753841 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MYL2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MYL2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC015821

Sigma-Aldrich siRNA for MYL2

Sigma-Aldrich shRNA for MYL2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000432

REFSEQ mRNAs for MYL2 gene:

NM_000432.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000432

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000432
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000432
                                 untagged cDNA clones in CMV expression vector (see all 2): BC015821

Additional cDNA sequence:

AF020768.1 AK312013.1 BC015821.1 BC031006.1 BC031008.1 BX538165.1 CR456962.1 CR541957.1

M22815.1 S69022.1 X14332.1 X57542.1 X66141.1

23 DOTS entries:

DT.450585 DT.100798453 DT.100798459 DT.100798457 DT.102837501 DT.102837503 DT.121215659 DT.75100621

DT.100798451 DT.100659582 DT.121215668 DT.95359103 DT.102837506 DT.102837507 DT.97775874 DT.102837504

DT.102837508 DT.121215675 DT.40133503 DT.92445757 DT.95359069 DT.95359075 DT.95359067

24/587 AceView cDNA sequences (see all 587 ):

C05566 AA346121 F35611 F28799 BC031006 AA346120 BM724247 C05576

C05403 AJ709626 F20573 C05506 CR541957 AJ709384 C05402 AJ709126

AJ710158 AJ710550 F26807 C05484 AA180217 AJ709651 AI286234 F36271

highest scoring ESTs for MYL2:

X66141 AA089616 AA112830 AA176729 AA176746 AA180105 AA180760 AA182946 AA192641 AA196659

Unigene Cluster for MYL2:

Myosin, light chain 2, regulatory, cardiac, slow

Hs.75535 [show with all ESTs]

Unigene Representative Sequence: BF673973

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for MYL2

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6	^	7
SP1:					-				-
SP2:					-		-
SP3:

About this scheme

ECgene alternative splicing isoforms for MYL2

1 Ensembl transcript including schematic representation:

ENST00000228841

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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MYL2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MYL2

¹ / ² / ³

3 probe-sets matching MYL2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36640_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X66141	1.00	1.00	1.00	1
209742_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF020768	0.60	1.00	0.82	1
209742_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks MYL2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTCCAATAAA

SOURCE GeneReport for Unigene cluster: Hs.75535
Expression variation in blood from EXPOLDB for MYL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MYL2 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MYL2¹	--	myosin, light chain 2, regulatory, cardiac, slow	92.17(n) 97.59(a)	403614 NM_001003069.1 NP_001003069.1
chimpanzee (Pan troglodytes)	MYL2¹	--	myosin, light chain 2, regulatory, cardiac, slow	91.16(n) 90.36(a)	452243 XM_509371.2 XP_509371.2
cow (Bos taurus)	MYL2¹	--	myosin, light chain 2, regulatory, cardiac, slow	90.16(n) 95.18(a)	505519 NM_001035025.1 NP_001030197.1
rat (Rattus norvegicus)	Myl2¹	--	myosin, light polypeptide 2, regulatory, cardiac, slow	81.82(n) 87.88(a)	363925 NM_001035252.1 NP_001030329.1
mouse (Mus musculus)	Myl2^{1, 5}	5⁵	myosin, light polypeptide 2, regulatory, cardiac, slow^{1, 5}	85.14(n)¹ 95.78(a)¹	17906¹ NM_010861.2¹ NP_034991.2¹ AF302688⁵ AK002367⁵ (see all 8)

About this table Species with no ortholog for MYL2

ENSEMBL Gene Tree for MYL2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MYL2 gene

MYL10² MYLPF²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/196 NCBI SNPs in MYL2 are shown (see all 196 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 88)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4766517^1,2	A,C,F,H	109844095(+)	`TTACTC/GAAGAC`	1	--	ng3¹		12		EU EA WA NA	1046
	rs2857717^1,2	C,F,H	109832709(-)	`AGGAAC/AATAGC`	1	--	ng5¹		4		EU EA WA	416
	rs2428140^1,2	C,H	109837902(-)	`CCCTTG/CGTATG`	1	R/G	mis¹ ese³		4		EU EA WA	418
	rs2301358^1,2	F,H	109843237(-)	`TGGTCG/AGGGAG`	1	--	ng3¹		4		EU EA WA	404
	rs14881^1,2	C	109833182(-)	`CNTCTG/TTCCCT`	1	--	ut3¹ ese³		1		MN	184
--	rs12427105^1,2	C	109843924(+)	`agatgC/Tggaaa`	1	--	ng3¹		0	--	--	--	--
	rs2857731^1,2	H	109843563(-)	`GCTGTG/ATTAtt`	1	--	ng3¹ tfbs³		4		EU EA WA	420
	rs2233257^1,2	H	109842951(-)	`AACCTT/GGAATG`	1	--	ng3¹		4		EU EA WA	380
--	rs12302980^1,2	A	109844673(+)	`agagcA/Gagact`	1	--	ng3¹		0	--	--	--	--
	rs2301359^1,2	H	109843217(-)	`AGGAGA/GTGACA`	1	--	ng3¹		4		EU EA WA	414

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HapMap Linkage Disequilibrium images for MYL2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 160781 disorders: 608758 608758

UniProtKB/Swiss-Prot: MLRV_HUMAN, P10916

Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic type 10 (CMH10)

[MIM:608758]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by

ventricular hypertrophy, which is usually asymmetric and often involves the interventricular

septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be

readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from

benign to malignant forms with high risk of cardiac failure and sudden cardiac death

Defects in MYL2 are the cause of cardiomyopathy hypertrophic with mid-left ventricular

chamber type 2 (MVC2) [MIM:608758]. MVC2 is a very rare variant of familial hypertrophic

cardiomyopathy, characterized by mid-left ventricular chamber thickening

3 Novoseek disease relationships for MYL2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cardiomyopathy	48.69	2	17885681 (1), 9769337 (1)
hypertrophy	29.42	1	8576950 (1)
cardiac hypertrophy	26.33	2	7683979 (1), 8576950 (1)

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GeneTests: MYL2

Familial Hypertrophic Cardiomyopathy

Human Gene Mutation Database: MYL2
Genetic Association Database: MYL2
Human Genome Epidemiology Navigator: MYL2 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/70 PubMed articles for MYL2 gene (see all 70 ):

Systematic analysis of the regulatory and essential myosin light chain genes: genetic variants and mutations in hypertrophic cardiomyopathy. (PubMed id 12404107)^{3, 4, 6} Kabaeva Z.T.... Osterziel K.J. (2002)
Interaction of a conserved peptide domain in recombinant human ventricular myosin light chain-2 with myosin heavy chain. (PubMed id 8287067)^{1, 3, 4} Wadgaonkar R.... Siddiqui M.A. (1993)
Identification of two novel mutations in the ventricular regulatory myosin light chain gene (MYL2) associated with familial and classical forms of hypertrophic cardiomyopathy. (PubMed id 9535554)^{1, 3, 4} Flavigny J....Hainque B. (1998)
Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling. (PubMed id 16199542)^{3, 6} Ingles J.... Semsarian C. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy. (PubMed id 12707239)^{3, 4} Richard P....Komajda M. (2003)
Identification of the genotypes causing hypertrophic cardiomyopathy in northern Sweden. (PubMed id 12818575)^{3, 4} Moerner S.... Waldenstroem A. (2003)
Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle. (PubMed id 8673105)^{3, 4} Poetter K.... Epstein N.D. (1996)
The major protein expression profile and two-dimensional protein database of human heart. (PubMed id 7498159)^{3, 4} Kovalyov L.I.... Musalyamov A.K. (1995)
Localization of the gene coding for ventricular myosin regulatory light chain (MYL2) to human chromosome 12q23-q24.3. (PubMed id 1386340)^{2, 3} Macera M.J....Verma R.S. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4633	HGNC: 7583	AceView: MYL2	Ensembl:ENSG00000111245	euGenes: HUgn4633
ECgene: MYL2	H-InvDB: MYL2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MYL2	Genetics and Cytogenetics in Oncology and Haematology
Familial hypertrophic cardiomyopathy mutation database	http://www.angis.org.au/Databases/Heart/heartbreak.html
GeneReviews	http://www.genetests.org/query?gene=MYL2

Licensable Technologies for MYL2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MYL2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MYL2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MYL2		Antibodies for MYL2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MYL2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MYL2)
	Antibodies (MYL2)
	Chimera RNAi (MYL2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Myosin Light Chain 2, Myosin light chain hHS-M21 phosphatase)
	Antibodies (Myosin Light Chain 2, Myosin light chain hHS-M21 phosphatase)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for MYL2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MYL2

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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MYL2 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for MYL2

Summaries
for MYL2

Genomic Location
for MYL2

Proteins
for MYL2

Protein Domains/
Families
for MYL2

Gene Function
for MYL2

Pathways & Interactions
for MYL2

Drugs & Compounds
for MYL2

Transcripts
for MYL2

Expression
for MYL2

Orthologs
for MYL2

Paralogs
for MYL2

SNPs/Variants
for MYL2

Disorders & Mutations
for MYL2

Medical News
for MYL2

Publications
for MYL2

Search for MYL2

Genome Databases showing MYL2

Other Databases showing MYL2

Specialized Databases showing MYL2

Licensable Technologies
for MYL2

Services
for MYL2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MYL2 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor MYL2

Summariesfor MYL2

Genomic Locationfor MYL2

Proteinsfor MYL2

Protein Domains/Familiesfor MYL2

Gene Functionfor MYL2

Pathways & Interactionsfor MYL2

Drugs & Compoundsfor MYL2

Transcriptsfor MYL2

Expression for MYL2

Orthologsfor MYL2

Paralogsfor MYL2

SNPs/Variantsfor MYL2

Disorders & Mutationsfor MYL2

Medical Newsfor MYL2

Publicationsfor MYL2

Search for MYL2

Genome Databases showing MYL2

Other Databases showing MYL2

Specialized Databases showing MYL2

Licensable Technologiesfor MYL2

Servicesfor MYL2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MYL2

Summaries
for MYL2

Genomic Location
for MYL2

Proteins
for MYL2

Protein Domains/
Families
for MYL2

Gene Function
for MYL2

Pathways & Interactions
for MYL2

Drugs & Compounds
for MYL2

Transcripts
for MYL2

Expression
for MYL2

Orthologs
for MYL2

Paralogs
for MYL2

SNPs/Variants
for MYL2

Disorders & Mutations
for MYL2

Medical News
for MYL2

Publications
for MYL2

Licensable Technologies
for MYL2

Services
for MYL2