Aliases for MYL12B Gene
External Ids for MYL12B Gene
Previous GeneCards Identifiers for MYL12B Gene
The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008]
GeneCards Summary for MYL12B Gene
MYL12B (Myosin, Light Chain 12B, Regulatory) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is MYL12A.
UniProtKB/Swiss-Prot for MYL12B Gene
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).