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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYL12B Gene

protein-coding   GIFtS: 54
GCID: GC18P003254

myosin, light chain 12B, regulatory
 Explore 4 diseases affiliated with
MYL12B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MYL12B    

Aliases
for MYL12B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Myosin, Light Chain 12B, Regulatory1 2     MLC202 3
MRLC21 2 3 5     SHUJUN-12 3
Myosin Regulatory Light Chain 2-B, Smooth Muscle Isoform2 3     MLC-B2
Myosin Regulatory Light Chain 20 KDa2 3     Myosin Regulatory Light Chain 12B2
Myosin Regulatory Light Chain MRLC22 3     Myosin Regulatory Light Chain 22
MLC-22 3     MYLC2B3
MLC-2A2 3     

External Ids:    HGNC: 298271   Entrez Gene: 1039102   Ensembl: ENSG000001186807   OMIM: 6092115   UniProtKB: O149503   

Export aliases for MYL12B gene to outside databases


Summaries
for MYL12B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MYL12B:
The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain,
such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments
(Iwasaki et al., 2001 (PubMed 11942626)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: ML12B_HUMAN, O14950
Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell
contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle.
Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity)




Genomic Views
for MYL12B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010859.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYL12B gene promoter:
         Sox5   C/EBPbeta   LCR-F1   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MYL12B promoter sequence
   Search SABiosciences Chromatin IP Primers for MYL12B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYL12B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.31   Ensembl cytogenetic band:  18p11.31   HGNC cytogenetic band: 18p11.31

MYL12B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL12B gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P003254:  view genomic region     (about GC identifiers)

Start:
 3,261,907 bp from pter      End:
 3,278,282 bp from pter
Size:
 16,376 bases      Orientation:
 plus strand

Proteins
for MYL12B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ML12B_HUMAN, O14950 (See protein sequence)
Recommended Name: Myosin regulatory light chain 12B  
Size: 172 amino acids; 19779 Da
Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains
Miscellaneous: This chain binds calcium (By similarity)
Sequence caution: Sequence=AAP73808.1; Type=Frameshift; Positions=4;
Secondary accessions: D3DUH6 Q13182 Q7Z5Z4

Explore the universe of human proteins at neXtProt for MYL12B: NX_O14950

Post-translational modifications:

  • Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It
    • is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2
    at the leading edge. Phosphorylation is reduced following epigallocatechin-3-O-gallate treatment1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14950

    • MYL12B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138416.1  NP_001138417.1  NP_291024.1  

    ENSEMBL proteins: 
     ENSP00000237500   ENSP00000463559   ENSP00000383037   ENSP00000464464  
    Reactome Protein details: O14950
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 4): MYL12B
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    Novus Biologicals MYL12B Proteins
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    ProSpec Recombinant Protein for MYL12B
    Uscn Proteins for MYL12B

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IEA--
    GO:0005829cytosol TAS--
    GO:0016460myosin II complex IEA--
    GO:0030018Z disc IEA--
    GO:0043234protein complex ----


    MYL12B for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MYL12B

    Protein Domains /
    Families
    for MYL12B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MYL12B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR018247 EF_Hand_1_Ca_BS
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd

    Graphical View of Domain Structure for InterPro Entry O14950

    ProtoNet protein and cluster: O14950

    UniProtKB/Swiss-Prot: ML12B_HUMAN, O14950
    Similarity: Contains 3 EF-hand domains


    Function
    for MYL12B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ML12B_HUMAN, O14950
    Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell
    contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle.
    Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYL12B
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate MYL12B:
    hsa-miR-23b hsa-miR-130a* hsa-miR-3920 hsa-miR-23a hsa-miR-23c hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: MYL12B 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYL12B (see all 6)
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    Cell Line
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    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MYL12B

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI19328794


    MYL12B for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MYL12B:
     Synthetic lethal with Ras 

    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Myl12b):
     hematopoietic system  homeostasis/metabolism  immune system 

    MYL12B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MYL12B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_Integrin-mediated cell adhesion and migration
    		Cell adhesion_Integrin-mediated cell adhesion and migration1.00
    		Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    		Cell adhesion Integrin-mediated cell adhesion and migration1.00
    		Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases0.49
    2Immune response _CCR3 signaling in eosinophils
    		Immune response _CCR3 signaling in eosinophils1.00
    		Inhibitory action of Lipoxins on neutrophil migration0.51
    		Immune response CCR3 signaling in eosinophils1.00
    3Sema4D in semaphorin signaling
    		Sema4D in semaphorin signaling1.00
    		Semaphorin interactions0.44
    		Sema4D induced cell migration and growth-cone collapse0.83
    4Axon guidance
    		Axon guidance1.00
    		Developmental Biology0.69
    5Cell adhesion Tight junctions
    		Cell adhesion Tight junctions1.00
    		Cell adhesion_Tight junctions0.99

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 EMD Millipore Pathways for MYL12B
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils
    Development MAG-dependent inhibition of neurite outgrowth


    5/6 GeneGo (Thomson Reuters) Pathways for MYL12B (see all 6)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Tight junctions

    1 BioSystems Pathway for MYL12B 
        TSH signaling pathway

    5/7        Reactome Pathways for MYL12B (see all 7)
        Developmental Biology
    Sema4D induced cell migration and growth-cone collapse
    Semaphorin interactions
    Smooth Muscle Contraction
    Muscle contraction


    4         Kegg Pathways  (Kegg details for MYL12B):
        Focal adhesion
    Tight junction
    Leukocyte transendothelial migration
    Regulation of actin cytoskeleton


    MYL12B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYL12B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/61 Interacting proteins for MYL12B (O149501, 3 ENSP000002375004) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYLIPQ8WY643, ENSP000003492984I2D: score=2 STRING: ENSP00000349298
    USP45Q70EL23, ENSP000003333764I2D: score=2 STRING: ENSP00000333376
    PNKDQ8N4903, ENSP000002730774I2D: score=1 STRING: ENSP00000273077
    BECN1Q144573, ENSP000003552314I2D: score=1 STRING: ENSP00000355231
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction TAS--
    GO:0007411axon guidance TAS--
    GO:0008360regulation of cell shape IEA--


    MYL12B for ontologies           About GeneDecksing



    Drugs & Compounds
    for MYL12B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MYL12B

    1 HMDB Compound for MYL12B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about MYL12B / ML12B 

    Transcripts
    for MYL12B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MYL12B gene (4 alternative transcripts): 
    NM_001144946.1  NM_001144944.1  NM_001144945.1  NM_033546.3  

    Unigene Cluster for MYL12B:

    Myosin, light chain 12B, regulatory
    Hs.464472  [show with all ESTs]
    Unigene Representative Sequence: BG029205
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000237500(uc002klt.4) ENST00000581193(uc010wyv.2) ENST00000400175(uc010dkl.3)
    ENST00000584539

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYL12B
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate MYL12B:
    hsa-miR-23b hsa-miR-130a* hsa-miR-3920 hsa-miR-23a hsa-miR-23c hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: MYL12B 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYL12B
    OriGene shRNA RFP: MYL12B
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYL12B
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK291726.1 AY320408.1 BC004994.1 D50372.1 D82058.1 U26162.1 

    24/26 DOTS entries (see all 26):

    DT.100686941  DT.92469540  DT.92410215  DT.91808621  DT.450689  DT.100686934  DT.100686930  DT.95278456 
    DT.100686926  DT.121084514  DT.95278489  DT.100686939  DT.121406633  DT.97846737  DT.100686931  DT.100686938 
    DT.40304309  DT.95278548  DT.121084534  DT.121084582  DT.121266965  DT.91926088  DT.92469421  DT.95278678 

    24/2090 AceView cDNA sequences (see all 2090):

    AA099444 D82058 CA431749 BQ019435 AA079802 BI064200 CN482800 CD369227 
    BM762242 BG576288 AA314746 BM311266 BM769892 CA412461 AI697424 CN484718 
    AI886199 CF128542 BE858261 CA867845 BU788073 BQ272022 BQ380034 BM768363 

    GeneLoc Exon Structure


    Expression
    for MYL12B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYL12B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAACTTAGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MYL12B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYL12B

    SOURCE GeneReport for Unigene cluster: Hs.464472

    UniProtKB/Swiss-Prot: ML12B_HUMAN, O14950
    Tissue specificity: Ubiquitously expressed in various hematopoietic cells

        SABiosciences Custom PCR Arrays for MYL12B
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MYL12B

    Orthologs
    for MYL12B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MYL12B gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves --
    MLRN_CHICK6
    		 Uncharacterized protein
    Myosin regulatory light chain 2, smooth muscle min...
    		 99(a)
    96(a)
    		 possible ortholog
    1 ↔ many
    		 2(103978239-103978757)
    2(103992047-103999180)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 97(a)
    		 possible ortholog
    		 4(42480830-42482809)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia 1420325682   -- 82.86(n)    142032568 
    zebrafish
    (Danio rerio)    		 Actinopterygii myl12.11 myosin, light chain 12, genome duplicate 1 80.23(n)
    91.86(a)    		   326719  NM_214699.1  NP_999864.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta sqh6
    Mlc26
    (see all 4)    		 Myosin light chain 2
    (see all 4)    		 81(a)
    30(a)
    (see all 4)    		 1 ↔ many
    possible ortholog
    (see all 4)    		 X(6117094-6119196)
    3R(25997160-26000273)
    worm
    (Caenorhabditis elegans)    		 Secernentea mlc-46
    		 Probable myosin regulatory light chain
    		 72(a)
    		 1 → many
    		 III(3392002-3393783)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 OsCML9 - Calmodulin-related calcium sensor protein...
    		 27(a)
    		 possible ortholog
    		 5(24067532-24068539)


    ENSEMBL Gene Tree for MYL12B (if available)
    TreeFam Gene Tree for MYL12B (if available) 

    Paralogs
    for MYL12B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYL12B gene
    MYL12A2  MYL72  MYL102  MYL92  MYL52  MYL22  MYLPF2  
    18/21 SIMAP similar genes for MYL12B using alignment to 1 protein entry:     ML12B_HUMAN(see all similar genes):
    MRLC3    MYL12A    MYL9    MYLPF    MYL2    MYL5
    CALM2    CALM1    MYL7    CALM3    CALML3    MYL10
    TNNC2    TNNC1    MYL6    CABP2    CABP5    CALML4

    MYL12B for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for MYL12B (see all 7)
    PGOHUM00000247098 PGOHUM00000245783 PGOHUM00000243594 PGOHUM00000245416 PGOHUM00000236897


    Genomic Variants
    for MYL12B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/387 NCBI SNPs in MYL12B are shown (see all 387)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs759908611,2
    		--3225222(+) TAAGAG/ATAAAT 1 -- us2k12Minor allele frequency- A:0.02CSA WA 120
    rs16623371,2
    		C,F,H,--3225348(-) ACACAT/CGATGC 1 -- us2k111Minor allele frequency- C:0.03EA NA NS CSA WA 958
    rs2018261261,2
    		C--3225875(+) ATCAAA/CCAGCC 1 -- us2k10--------
    rs739370411,2
    		C,--3225918(+) AACCTT/CATGAG 1 -- us2k12Minor allele frequency- C:0.04WA 120
    rs1114458521,2
    		--3226021(+) CAGGCG/ACCGCC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1128582951,2
    		C--3226631(+) CGGTTC/G/TTGGTG 1 -- us2k11CSA 1
    rs562964811,2
    		C,--3227245(+) TCGCTC/TAGTGT 1 -- int12Minor allele frequency- T:0.05WA 120
    rs359219181,2
    		C,--3227484(+) GCGGG-/TATGGA 1 -- int10--------
    rs743492411,2
    		F,--3228012(+) AACAGG/CATTTA 1 -- int12Minor allele frequency- C:0.10WA NA 238
    rs800820421,2
    		C,--3228032(+) CATGGG/AGCTAG 1 -- int14Minor allele frequency- A:0.09CSA WA NA EA 360

    HapMap Linkage Disequilibrium report for MYL12B (3261907 - 3278282 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MYL12B: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for MYL12B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MYL12B for disorders           About GeneDecksing

    OMIM gene information: 609211    OMIM disorders: --

    4 diseases for MYL12B:    About MalaCards
    double outlet right ventricle    megakaryoblastic leukemia    leukemia    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for MYL12B:
    Double outlet right ventricle

    Export disorders for MYL12B gene to outside databases

    Publications
    for MYL12B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYL12B gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with MYL12B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells. (PubMed id 11942626)1, 2, 3 Iwasaki T.... Hosoya H. (2001)
    2. Epigallocatechin-3-O-gallate disrupts stress fibers and the contractile ring by reducing myosin regulatory light chain phosphorylation mediated through the target molecule 67 kDa laminin receptor. (PubMed id 15946647)1, 2 Umeda D.... Yamada K. (2005)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. Phosphorylation of myosin II regulatory light chain co ntrols its accumulation, not that of actin, at the contractile ring in HeLa cell s. (PubMed id 22374324)1 Kondo T....Hosoya H. (2012)
    5. Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (2012)
    6. Diphosphorylated but not monophosphorylated myosin II regulatory light chain localizes to the midzone without its heavy chain during c ytokinesis. (PubMed id 22166199)1 Kondo T....Hosoya H. (2012)
    7. Genetically distinct subsets within ANCA-associated va sculitis. (PubMed id 22808956)1 Lyons P.A....Smith K.G. (2012)
    8. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
    9. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
    10. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)

    External Searches for MYL12B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing MYL12B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 103910 HGNC: 29827 AceView: MRCL3andMRLC2 Ensembl:ENSG00000118680 euGenes: HUgn103910
    ECgene: MYL12B Kegg: 103910 H-InvDB: MYL12B

    Other Databases showing MYL12B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MYL12B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYL12B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MYL12B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MYL12B gene:
    Search GeneIP for patents involving MYL12B

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