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Aliases for MYL12A Gene

Aliases for MYL12A Gene

  • Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric 2 3
  • Myosin, Light Polypeptide, Regulatory, Non-Sarcomeric (20kD) 2 3
  • Myosin Regulatory Light Chain 2, Nonsarcomeric 3 4
  • Myosin Regulatory Light Chain MRLC3 3 4
  • Epididymis Secretory Protein Li 24 3 4
  • Myosin Regulatory Light Chain 3 2 3
  • Myosin RLC 3 4
  • HEL-S-24 3 4
  • MLC-2B 3 4
  • MRLC3 3 4
  • MLCB 3 4
  • Myosin Regulatory Light Chain 12A 3
  • MRCL3 3
  • MYL2B 3
  • RLC 4

External Ids for MYL12A Gene

Summaries for MYL12A Gene

Entrez Gene Summary for MYL12A Gene

  • This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014]

GeneCards Summary for MYL12A Gene

MYL12A (Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include calcium ion binding and glutamate receptor binding. An important paralog of this gene is MYLPF.

UniProtKB/Swiss-Prot for MYL12A Gene

  • Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).

Gene Wiki entry for MYL12A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL12A Gene

Genomics for MYL12A Gene

Genomic Location for MYL12A Gene

Start:
3,247,474 bp from pter
End:
3,256,236 bp from pter
Size:
8,763 bases
Orientation:
Plus strand

Genomic View for MYL12A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYL12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL12A Gene

Regulatory Elements for MYL12A Gene

Proteins for MYL12A Gene

  • Protein details for MYL12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19105-ML12A_HUMAN
    Recommended name:
    Myosin regulatory light chain 12A
    Protein Accession:
    P19105
    Secondary Accessions:
    • Q53X45

    Protein attributes for MYL12A Gene

    Size:
    171 amino acids
    Molecular mass:
    19794 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains
    Miscellaneous:
    • This chain binds calcium

neXtProt entry for MYL12A Gene

Proteomics data for MYL12A Gene at MOPED

Post-translational modifications for MYL12A Gene

  • Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge (By similarity).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys50, Lys149, and Lys150

No data available for DME Specific Peptides for MYL12A Gene

Domains for MYL12A Gene

Gene Families for MYL12A Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • MYL :Myosins / Light chain

Protein Domains for MYL12A Gene

UniProtKB/Swiss-Prot:

ML12A_HUMAN
Domain:
  • Contains 3 EF-hand domains.:
    • P19105
genes like me logo Genes that share domains with MYL12A: view

Function for MYL12A Gene

Molecular function for MYL12A Gene

UniProtKB/Swiss-Prot Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).

Gene Ontology (GO) - Molecular Function for MYL12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 21457715
GO:0035254 glutamate receptor binding IEA --
genes like me logo Genes that share ontologies with MYL12A: view

Phenotypes for MYL12A Gene

GenomeRNAi human phenotypes for MYL12A:
genes like me logo Genes that share phenotypes with MYL12A: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MYL12A Gene

Localization for MYL12A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYL12A Gene COMPARTMENTS Subcellular localization image for MYL12A gene
Compartment Confidence
cytoskeleton 3
cytosol 3
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MYL12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IEA --
GO:0005829 cytosol TAS --
GO:0016460 myosin II complex IEA --
GO:0030018 Z disc IEA --
GO:0043234 protein complex --
genes like me logo Genes that share ontologies with MYL12A: view

Pathways for MYL12A Gene

genes like me logo Genes that share pathways with MYL12A: view

Gene Ontology (GO) - Biological Process for MYL12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS --
GO:0007411 axon guidance TAS --
GO:0008360 regulation of cell shape IEA --
GO:0048013 ephrin receptor signaling pathway TAS --
GO:0070527 platelet aggregation IMP 23382103
genes like me logo Genes that share ontologies with MYL12A: view

Compounds for MYL12A Gene

(1) HMDB Compounds for MYL12A Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for MYL12A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID
target
genes like me logo Genes that share compounds with MYL12A: view

Transcripts for MYL12A Gene

Unigene Clusters for MYL12A Gene

Myosin, light chain 12A, regulatory, non-sarcomeric:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYL12A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - - -
SP2:
SP3: -

Relevant External Links for MYL12A Gene

GeneLoc Exon Structure for
MYL12A
ECgene alternative splicing isoforms for
MYL12A

Expression for MYL12A Gene

mRNA expression in normal human tissues for MYL12A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYL12A Gene

This gene is overexpressed in Heart - Left Ventricle (8.4), Whole Blood (6.0), and Muscle - Skeletal (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYL12A Gene

SOURCE GeneReport for Unigene cluster for MYL12A Gene Hs.190086

genes like me logo Genes that share expressions with MYL12A: view

Orthologs for MYL12A Gene

This gene was present in the common ancestor of animals.

Orthologs for MYL12A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYL12A 36
  • 99.42 (n)
  • 100 (a)
MYL12A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYL12B 36
  • 89.47 (n)
  • 97.66 (a)
MYL9 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 91 (a)
OneToMany
-- 37
  • 99 (a)
OneToMany
MYL12B 36
  • 92.87 (n)
  • 98.74 (a)
mouse
(Mus musculus)
Mammalia Myl12a 16
Myl12a 37
  • 98 (a)
OneToOne
Myl12b 36
  • 86.5 (n)
  • 99.37 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 94 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Myl12b 36
  • 84.81 (n)
  • 99.37 (a)
chicken
(Gallus gallus)
Aves MYL12A 37
  • 98 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 71 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii myl12.1 36
  • 80.59 (n)
  • 93.04 (a)
myl12.1 37
  • 92 (a)
ManyToMany
myl12.2 37
  • 95 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta sqh 37
  • 80 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mlc-4 37
  • 72 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5063 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5139 37
  • 81 (a)
OneToMany
Species with no ortholog for MYL12A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MYL12A Gene

ENSEMBL:
Gene Tree for MYL12A (if available)
TreeFam:
Gene Tree for MYL12A (if available)

Paralogs for MYL12A Gene

Paralogs for MYL12A Gene

Selected SIMAP similar genes for MYL12A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for MYL12A Gene

genes like me logo Genes that share paralogs with MYL12A: view

Variants for MYL12A Gene

Sequence variations from dbSNP and Humsavar for MYL12A Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs7811 -- 3,256,114(-) AATTA(C/T)CCTAT utr-variant-3-prime
rs716351 -- 3,253,050(-) ATATA(A/G)CTAAC intron-variant
rs717183 -- 3,252,926(-) AGGGA(C/T)ACTAA intron-variant
rs1056088 -- 3,248,266(+) TGTCC(C/T)CCTGC intron-variant
rs1056089 -- 3,248,376(+) TTTTT(C/T)TTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYL12A Gene

Variant ID Type Subtype PubMed ID
nsv909317 CNV Gain 21882294
esv275271 CNV Loss 21479260

Relevant External Links for MYL12A Gene

HapMap Linkage Disequilibrium report
MYL12A

Disorders for MYL12A Gene

(1) University of Copenhagen DISEASES for MYL12A Gene

genes like me logo Genes that share disorders with MYL12A: view

No data available for UniProtKB/Swiss-Prot for MYL12A Gene

Publications for MYL12A Gene

  1. Human nonsarcomeric 20,000 Da myosin regulatory light chain cDNA. (PMID: 2216787) Grant J.W. … Church S.L. (Nucleic Acids Res. 1990) 2 3 4
  2. Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells. (PMID: 11942626) Iwasaki T. … Hosoya H. (Cell Struct. Funct. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3
  5. Subtractive hybridisation screen identifies genes regulated by glucose deprivation in human neuroblastoma cells. (PMID: 17719568) Kobayashi K. … Russo V.C. (Brain Res. 2007) 3

Products for MYL12A Gene

  • antibodies-online proteins for MYL12A
  • antibodies-online antibodies for MYL12A
  • antibodies-online kits for MYL12A

Sources for MYL12A Gene

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