Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

MYL12A Gene

protein-coding GIFtS: 57
GCID: GC18P003238

Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric

(Previous names: myosin, light polypeptide, regulatory, non-sarcomeric (2...)

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric¹ ²		MLC-2B² ³
Myosin, Light Polypeptide, Regulatory, Non-Sarcomeric (20kD)¹ ²		MLCB² ³
Myosin Regulatory Light Chain 3¹ ²		MRLC3² ³
Epididymis Secretory Protein Li 24² ³		MRCL3²
Myosin Regulatory Light Chain 2, Nonsarcomeric² ³		MYL2B²
Myosin Regulatory Light Chain MRLC3² ³		Myosin Regulatory Light Chain 12A²
Myosin RLC² ³		Myosin Regulatory Light Chain MRCL3²
HEL-S-24² ³		RLC³

External Ids:	HGNC: 16701¹	Entrez Gene: 10627²	Ensembl: ENSG00000101608⁷	UniProtKB: P19105³

Export aliases for MYL12A gene to outside databases

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for MYL12A Gene:

MYL12A (myosin, light chain 12A, regulatory, non-sarcomeric) is a protein-coding gene. Diseases associated with MYL12A include familial hypertrophic cardiomyopathy, and hypertrophic cardiomyopathy. GO annotations related to this gene include glutamate receptor binding and calcium ion binding. An important paralog of this gene is MYL10.

UniProtKB/Swiss-Prot: ML12A_HUMAN, P19105

Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle

cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell

locomotion (By similarity)

Gene Wiki entry for MYL12A (MRCL3) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence:

NC_000018.10 NT_010859.15 NC_018929.2

Regulatory elements:

Regulatory transcription factor binding sites in the MYL12A gene promoter:
Sox5 C/EBPbeta HNF-4alpha2 LCR-F1 HNF-4alpha1 FOXO4 FOXO1a Chx10 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MYL12A promoter sequence

Search Chromatin IP Primers for MYL12A

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYL12A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.31 Ensembl cytogenetic band: 18p11.31 HGNC cytogenetic band: 18p11.31

MYL12A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL12A gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P003238: view genomic region (about GC identifiers)

Start:	3,247,479 bp from pter	End:	3,256,234 bp from pter
Size:	8,756 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ML12A_HUMAN, P19105 (See protein sequence)

Recommended Name: Myosin regulatory light chain 12A

Size: 171 amino acids; 19794 Da

Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains

Miscellaneous: This chain binds calcium

Secondary accessions: Q53X45

Explore the universe of human proteins at neXtProt for MYL12A: NX_P19105

Explore proteomics data for MYL12A at MOPED

Post-translational modifications:

Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile

activity. It is required to generate the driving force in the migration of the cells but not necessary for

localization of myosin-2 at the leading edge (By similarity)¹

Ubiquitination² at Lys50, Lys149, Lys150

Modification sites at PhosphoSitePlus

See MYL12A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_006462.1

ENSEMBL proteins:

ENSP00000462171 ENSP00000217652 ENSP00000463614 ENSP00000462865 ENSP00000463009

ENSP00000464359 ENSP00000441231

MYL12A Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for MYL12A OriGene Protein Over-expression Lysate for MYL12A OriGene MassSpec for MYL12A OriGene Custom Protein Services for MYL12A
	GenScript Custom Purified and Recombinant Proteins Services for MYL12A
	Novus Biologicals MYL12A Proteins Novus Biologicals MYL12A Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for MYL12A
	Cloud-Clone Corp. Proteins for MYL12A

MYL12A Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for MYL12A OriGene Custom Antibody Services for MYL12A
	Novus Biologicals MYL12A Antibodies
	Abcam antibodies for MYL12A
	Cloud-Clone Corp. Antibodies for MYL12A
	Search ThermoFisher Antibodies for MYL12A
	LSBio Antibodies in human, mouse, rat for MYL12A

MYL12A Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for MYL12A
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MYL12A
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for MYL12A Cloud-Clone Corp. CLIAs for MYL12A

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

HGNC Gene Families:

EFHAND: EF-hand domain containing

MYL: Myosins / Light chain

3 InterPro protein domains:

IPR011992 EF-hand-dom_pair

IPR002048 EF_hand_dom

IPR018247 EF_Hand_1_Ca_BS

Graphical View of Domain Structure for InterPro Entry P19105

ProtoNet protein and cluster: P19105

UniProtKB/Swiss-Prot: ML12A_HUMAN, P19105

Similarity: Contains 3 EF-hand domains

MYL12A for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: ML12A_HUMAN, P19105

Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle

cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell

locomotion (By similarity)

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	--
GO:0035254	glutamate receptor binding	IEA	--

MYL12A for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for MYL12A:

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYL12A

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYL12A

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYL12A

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYL12A

miRNA Products:		Block miRNA regulation of human, mouse, rat MYL12A using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MYL12A (see all 13):
		hsa-miR-320a hsa-miR-3607-3p hsa-miR-196a* hsa-miR-561 hsa-miR-622 hsa-miR-320d hsa-miR-146a* hsa-miR-320b

		SwitchGear 3'UTR luciferase reporter plasmid: MYL12A 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MYL12A
		Predesigned siRNA for gene silencing in human, mouse, rat MYL12A

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MYL12A

Clone Products:		OriGene clones in human, mouse for MYL12A (see all 6) OriGene ORF clones in mouse, rat for MYL12A OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MYL12A (NM_006471)
		Sino Biological Human cDNA Clone for MYL12A
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYL12A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYL12A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MYL12A
		Browse ESI BIO Cell Lines and PureStem Progenitors for MYL12A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL12A

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	3
cytosol	3
mitochondrion	2
nucleus	2

About this image

Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001725	stress fiber	IEA	--
GO:0016460	myosin II complex	IEA	--
GO:0030018	Z disc	IEA	--
GO:0043234	protein complex	--	--
GO:0070062	extracellular vesicular exosome	IDA	--

MYL12A for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for MYL12A About (see all 6)

See pathways by source

SuperPath

Contained pathways About

Immune response CCR3 signaling in eosinophils

Inhibitory action of Lipoxins on neutrophil migration

0.51

Immune response CCR3 signaling in eosinophils

0.51

Cell adhesion Integrin mediated cell adhesion and migration

	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases	0.49			Development MAG dependent inhibition of neurite outgrowth	0.46
	Cell adhesion Integrin mediated cell adhesion and migration	0.49			Cell adhesion Tight junctions	0.33

Focal adhesion

Focal adhesion

0.65

Regulation of actin cytoskeleton

Regulation of actin cytoskeleton

0.57

Tight junction

Tight junction

Pathways by source See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYL12A (see all 16)

	Activation of PKA through GPCR
	RhoA Pathway
	PKA Signaling
	Guidance Cues and Growth Cone Motility
	Antioxidant Action of Vitamin-C

Selected GeneGo (Thomson Reuters) Pathways for MYL12A (see all 6)

	Cell adhesion Integrin-mediated cell adhesion and migration
	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
	Inhibitory action of Lipoxins on neutrophil migration
	Immune response CCR3 signaling in eosinophils
	Cell adhesion Tight junctions

4 Kegg Pathways (Kegg details for MYL12A):

	Focal adhesion
	Tight junction
	Leukocyte transendothelial migration
	Regulation of actin cytoskeleton

MYL12A for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for MYL12A
Interactions:

Search GeneGlobe Interaction Network for MYL12A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for MYL12A (P19105^{1, 2, 3} ENSP00000217652⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 142)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CHUK	O15111²^,³, ENSP00000359424⁴	MINT-48063 I2D: score=2 STRING: ENSP00000359424
ACTB	P60709²^,³, ENSP00000349960⁴	MINT-7899812 I2D: score=1 STRING: ENSP00000349960
IKBKE	Q14164²^,³	MINT-48126 I2D: score=3
IKBKG	Q9Y6K9²^,³	MINT-48240 I2D: score=2
MAP3K3	Q99759²^,³	MINT-48521 I2D: score=2

About this table

Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008360	regulation of cell shape	IEA	--
GO:0072661	protein targeting to plasma membrane	IEA	--

MYL12A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for MYL12A (ML12A)

1 HMDB Compound for MYL12A About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

1 DrugBank Compound for MYL12A About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID	--	--	target	--	10592235

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for MYL12A gene:

NM_006471.2

Unigene Cluster for MYL12A:

Myosin, light chain 12A, regulatory, non-sarcomeric

Hs.190086 [show with all ESTs]

Unigene Representative Sequence: AK057715

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000579226 ENST00000217652(uc002klr.3) ENST00000580353 ENST00000578611

ENST00000585090 ENST00000583449 ENST00000608786 ENST00000578562 ENST00000577510

ENST00000580887 ENST00000578038 ENST00000536605(uc002kls.3)

miRNA Products:		Block miRNA regulation of human, mouse, rat MYL12A using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MYL12A (see all 13):
		hsa-miR-320a hsa-miR-3607-3p hsa-miR-196a* hsa-miR-561 hsa-miR-622 hsa-miR-320d hsa-miR-146a* hsa-miR-320b

		SwitchGear 3'UTR luciferase reporter plasmid: MYL12A 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MYL12A
		Predesigned siRNA for gene silencing in human, mouse, rat MYL12A

Clone Products:		OriGene clones in human, mouse for MYL12A (see all 6) OriGene ORF clones in mouse, rat for MYL12A OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MYL12A (NM_006471)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYL12A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYL12A

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for MYL12A
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat MYL12A
		QuantiTect SYBR Green Assays in human, mouse, rat MYL12A
		QuantiFast Probe-based Assays in human, mouse, rat MYL12A

Additional mRNA sequence:

AK057715.1 AK222569.1 AK291145.1 BC016372.1 BC031972.1 BC032748.1 D82059.1 DQ185044.1

X54304.1

Selected DOTS entries (see all 68):

DT.86995292 DT.92469460 DT.92469476 DT.92059759 DT.100686941 DT.100673841 DT.92469540 DT.95278663

DT.97866616 DT.91808621 DT.450689 DT.92410215 DT.121084602 DT.91661473 DT.121084507 DT.92469528

DT.95278367 DT.121084548 DT.121084560 DT.121084565 DT.100686933 DT.92469415 DT.100673835 DT.91808025

Selected AceView cDNA sequences (see all 2090):

BQ010305 AW002027 BQ772839 CB157507 CA417972 BI086527 BU902799 BX345631

CD369769 BI057174 BM842441 BM975089 CA307555 BI064082 AV714198 BQ775475

CF127911 BF742858 BQ582241 CD368287 BQ935838 BG028879 BQ073698 CB068622

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for MYL12A About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b
SP1:			-		-		-
SP2:
SP3:							-

ECgene alternative splicing isoforms for MYL12A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

MYL12A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCCTTAGCTT

About this image

MYL12A expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 18) fully expand


Bone (Muscoskeletal System)
Bone Marrow

Colon (Gastrointestinal Tract)

Uterus (Reproductive System)

Thyroid (Endocrine System)

Testis (Reproductive System)

MYL12A Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

MYL12A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.190086

Custom PCR Arrays for MYL12A

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for MYL12A
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat MYL12A
		QuantiTect SYBR Green Assays in human, mouse, rat MYL12A
		QuantiFast Probe-based Assays in human, mouse, rat MYL12A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL12A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for MYL12A gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Myl12a⁵ Myl12b¹	myosin, light chain 12A, regulatory, non-sarcomeric⁵ myosin, light chain 12B, regulatory¹	86.5(n)¹ 99.37(a)¹		17 (41.87 cM)⁵ 67938¹ NM_023402.2¹ NP_075891.1¹ 70993656⁵
chicken (Gallus gallus)	Aves	MYL12A⁶	Gallus gallus myosin, light chain 12A, regulatory,...	98(a)	many ↔ many	2(100543631-100550803)
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	71(a)	1 → many	GL343470.1(472422-472746)
zebrafish (Danio rerio)	Actinopterygii	myl12.1¹	myosin, light chain 12, genome duplicate 1	80.59(n) 93.04(a)		326719 NM_214699.1 NP_999864.1
fruit fly (Drosophila melanogaster)	Insecta	sqh⁶	spaghetti squash	80(a)	1 → many	X(6117094-6119196)
worm (Caenorhabditis elegans)	Secernentea	mlc-4⁶	Protein MLC-4 (mlc-4) mRNA, complete cds	72(a)	1 → many	III(3392013-3393787) WBGene00003372

ENSEMBL Gene Tree for MYL12A (if available)
TreeFam Gene Tree for MYL12A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for MYL12A gene

MYL10² MYL7² MYL9² MYL5² MYL2² MYLPF² MYL12B²

Selected SIMAP similar genes for MYL12A using alignment to 4 protein entries: ML12A_HUMAN (see all proteins) (see all similar genes):

MYL12B MYL9 MYLPF MYL5 MYL2 MYL7

CALM2 CALM1 CALM3 CALML3 MYL10 TNNC2

CALML4 TNNC1 CABP2 MYL6 CABP5 CALML5

MYL12A for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for MYL12A
PGOHUM00000249747

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147029016^1,2		--	3245564(+)	`TTATCA/GAGATG`	1	--	us2k¹		0	--	--	--	--
rs201102054^1,2		--	3245572(+)	`TGCTA-/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs35982350^1,2	C	--	3245577(+)	`TTTTTC/-CCACA`	1	--	us2k¹		1		NA	2
rs1443130^1,2	C,F,A	--	3245755(-)	`ATTCAG/CTGGGG`	1	--	us2k¹		7		NA WA CSA EA	365
rs3819225^1,2	C,F	--	3245828(-)	`CGAAGC/AGTAAA`	1	--	us2k¹ tfbs³		6		NA WA EA	364
rs151010922^1,2		--	3245921(+)	`CTCCGC/TATTTT`	1	--	us2k¹		0	--	--	--	--
rs192908293^1,2	C	--	3246037(+)	`TAATAC/TCTGCT`	1	--	us2k¹		0	--	--	--	--
rs9956222^1,2	C,F,A,H	--	3246064(+)	`GACAAA/GACAAT`	1	--	us2k¹		11		NS NA WA CSA	1191
rs185470115^1,2		--	3246117(+)	`GAGGGA/GAAGAC`	1	--	us2k¹		0	--	--	--	--
rs3819224^1,2	C,F	--	3246265(-)	`CTGCGC/TGGATG`	1	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for MYL12A (3247479 - 3256234 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for MYL12A: About this table

Variant ID	Type	Subtype	PubMed ID
esv275271	CNV	Loss	21479260
nsv909317	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MYL12A

DNA2.0 Custom Variant and Variant Library Synthesis for MYL12A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

6 diseases for MYL12A:
About MalaCards

familial hypertrophic cardiomyopathy hypertrophic cardiomyopathy neuroblastoma hiv-1

malaria endotheliitis

1 disease from the University of Copenhagen DISEASES database for MYL12A:

Familial hypertrophic cardiomyopathy

MYL12A for disorders About GeneDecksing

Export disorders for MYL12A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for MYL12A gene, integrated from 10 sources (see all 30):
(articles sorted by number of sources associating them with MYL12A)

Utopia: connect your pdf to the dynamic
world of online information

Human nonsarcomeric 20,000 Da myosin regulatory light chain cDNA. (PubMed id 2216787)^{1, 2, 3} Grant J.W.... Church S.L. (Nucleic Acids Res. 1990)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells. (PubMed id 11942626)^{1, 2} Iwasaki T.... Hosoya H. (Cell Struct. Funct. 2001)
A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)¹ Leng L....Wang J. (J. Proteome Res. 2014)
A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)¹ Weimann M.... Stelzl U. (Nat. Methods 2013)
Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)¹ Zanon A....Pichler I. (PLoS ONE 2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (Sci Signal 2012)
Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)¹ Chuang J.Y....Hung J.J. (Oncogene 2012)
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 10627	HGNC: 16701	AceView: MRCL3andMRLC2	Ensembl:ENSG00000101608	euGenes: HUgn10627
ECgene: MYL12A	Kegg: 10627	H-InvDB: MYL12A

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for MYL12A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MYL12A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for MYL12A gene:
Search GeneIP for patents involving MYL12A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for MYL12A		OriGene RNAi products in human, mouse, rat for MYL12A
	Browse OriGene qPCR primer pairs and template standards		OriGene Protein Over-expression Lysate for MYL12A
	OriGene MassSpec something-or-other for MYL12A		OriGene clones in human, mouse for MYL12A
	OriGene qSTAR qPCR primer pairs in human, mouse for MYL12A		OriGene Purified Protein for MYL12A
	OriGene ORF clones in mouse, rat for MYL12A		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MYL12A		OriGene Custom Protein Services for MYL12A

	Block miRNA regulation of human, mouse, rat MYL12A using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing MYL12A
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYL12A		Predesigned siRNA for gene silencing in human, mouse, rat MYL12A
	QuantiFast Probe-based Assays in human, mouse, rat MYL12A		QuantiTect SYBR Green Assays in human, mouse, rat MYL12A
	Custom PCR Arrays for MYL12A		Search Chromatin IP Primers for MYL12A
	Pre-validated RT² qPCR Primer Assay in human, mouse / rat MYL12A		Search GeneGlobe Interaction Network for MYL12A
	Regulatory tfbs in MYL12A promoter

	GenScript Custom Purified and Recombinant Proteins Services for MYL12A		GenScript cDNA clones with any tag delivered in your preferred vector for MYL12A
	GenScript Custom Assay Services for MYL12A		GenScript Custom overexpressing Cell Line Services for MYL12A
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for MYL12A (ML12A)

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	cDNA Clones for MYL12A
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	MYL12A antibodies
	MYL12A proteins
	MYL12A lysates

	Antibodies for MYL12A
	See all of Abcam's Antibodies, Kits and Proteins for MYL12A
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for MYL12A

	Proteins for MYL12A
	Antibodies for MYL12A
	ELISAs for MYL12A
	CLIAs for MYL12A

Browse ESI BIO Cell Lines and PureStem Progenitors for MYL12A

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL12A

	SwitchGear 3'UTR luciferase reporter plasmids for MYL12A
	SwitchGear Promoter luciferase reporter plasmids for MYL12A

Search ThermoFisher Antibodies for MYL12A

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYL12A

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYL12A
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYL12A

LSBio Antibodies in human, mouse, rat for MYL12A

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

Browse compounds at ApexBio

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MYL12A gene at Home site.

Version: 3.12.142 28 July 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

MYL12A Gene

Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric

Aliases
for MYL12A gene

Summaries
for MYL12A gene

Genomic Views
for MYL12A gene

Proteins
for MYL12A gene

MYL12A Human Recombinant Protein Products:

MYL12A Antibody Products:

MYL12A Assay Products:

Domains /
Families
for MYL12A gene

Function
for MYL12A gene

Localization
for MYL12A gene

Pathways & Interactions
for MYL12A gene

Drugs & Compounds
for MYL12A gene

Transcripts
for MYL12A gene

Expression
for MYL12A gene

Orthologs
for MYL12A gene

Paralogs
for MYL12A gene

Genomic Variants
for MYL12A gene

Disorders / Diseases
for MYL12A gene

Publications
for MYL12A gene

External Searches for MYL12A gene

Genome Databases showing MYL12A gene

Other Databases showing MYL12A gene

Specialized Databases showing MYL12A gene

Intellectual Property
for MYL12A gene

Products
for MYL12A gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

MYL12A Gene

Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric

Aliasesfor MYL12A gene

Summariesfor MYL12A gene

Genomic Viewsfor MYL12A gene

Proteinsfor MYL12A gene

MYL12A Human Recombinant Protein Products:

MYL12A Antibody Products:

MYL12A Assay Products:

Domains /Familiesfor MYL12A gene

Functionfor MYL12A gene

Localizationfor MYL12A gene

Pathways & Interactionsfor MYL12A gene

Drugs & Compoundsfor MYL12A gene

Transcriptsfor MYL12A gene

Expression for MYL12A gene

Orthologsfor MYL12A gene

Paralogsfor MYL12A gene

Genomic Variantsfor MYL12A gene

Disorders / Diseasesfor MYL12A gene

Publicationsfor MYL12A gene

External Searches for MYL12A gene

Genome Databases showing MYL12A gene

Other Databases showing MYL12A gene

Specialized Databases showing MYL12A gene

Intellectual Propertyfor MYL12A gene

Productsfor MYL12A gene

View Random Gene

Aliases
for MYL12A gene

Summaries
for MYL12A gene

Genomic Views
for MYL12A gene

Proteins
for MYL12A gene

Domains /
Families
for MYL12A gene

Function
for MYL12A gene

Localization
for MYL12A gene

Pathways & Interactions
for MYL12A gene

Drugs & Compounds
for MYL12A gene

Transcripts
for MYL12A gene

Expression
for MYL12A gene

Orthologs
for MYL12A gene

Paralogs
for MYL12A gene

Genomic Variants
for MYL12A gene

Disorders / Diseases
for MYL12A gene

Publications
for MYL12A gene

Intellectual Property
for MYL12A gene

Products
for MYL12A gene