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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYL12A Gene

protein-coding   GIFtS: 55
GCID: GC18P003238

myosin, light chain 12A, regulatory, non-sarcomeric

(Previous names: myosin, light polypeptide, regulatory, non-sarcomeric (2...)
 Explore 1 disease affiliated with
MYL12A via our new
 Human Malady Compendium 
Biological research products
for MYL12A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric1 2     Myosin Regulatory Light Chain MRLC32 3
MLCB1 2 3     Myosin RLC2 3
MRLC31 2 3     MLC-2B2 3
MRCL31 2     Myosin Regulatory Light Chain 12A2
MYL2B1 2     Myosin Regulatory Light Chain 32
Myosin, Light Polypeptide, Regulatory, Non-Sarcomeric (20kD)1 2     Myosin Regulatory Light Chain MRCL32
Myosin Regulatory Light Chain 2, Nonsarcomeric2 3     RLC3

External Ids:    HGNC: 167011   Entrez Gene: 106272   Ensembl: ENSG000001016087   UniProtKB: P191053   

Export aliases for MYL12A gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ML12A_HUMAN, P19105
Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell
contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By
similarity)

Gene Wiki entry for MYL12A (MRCL3)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010859.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYL12A gene promoter:
         Sox5   C/EBPbeta   HNF-4alpha2   LCR-F1   HNF-4alpha1   FOXO4   FOXO1a   Chx10   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYL12A promoter sequence
   Search SABiosciences Chromatin IP Primers for MYL12A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYL12A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.31   Ensembl cytogenetic band:  18p11.31   HGNC cytogenetic band: 18p11.31

MYL12A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL12A gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P003238:  view genomic region     (about GC identifiers)

Start:
3,247,479 bp from pter      End:
3,256,234 bp from pter
Size:
8,756 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ML12A_HUMAN, P19105 (See protein sequence)
Recommended Name: Myosin regulatory light chain 12A  
Size: 171 amino acids; 19794 Da
Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains
Miscellaneous: This chain binds calcium

Explore the universe of human proteins at neXtProt for MYL12A: NX_P19105

Post-translational modifications:

  • Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It
  • is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2
    at the leading edge (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P19105

  • MYL12A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006462.1  
    ENSEMBL proteins: 
     ENSP00000462171   ENSP00000217652   ENSP00000463614   ENSP00000462865   ENSP00000463009  
     ENSP00000464359   ENSP00000441231  

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    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IEA--
    GO:0016459myosin complex ----
    GO:0016460myosin II complex IEA--
    GO:0030018Z disc IEA--
    GO:0043234protein complex ----


    MYL12A for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MYL12A for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018247 EF_Hand_1_Ca_BS
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR018248 EF-hand

    Graphical View of Domain Structure for InterPro Entry P19105

    ProtoNet protein and cluster: P19105

    UniProtKB/Swiss-Prot: ML12A_HUMAN, P19105
    Similarity: Contains 3 EF-hand domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ML12A_HUMAN, P19105
    Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell
    contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By
    similarity)

    miRNA
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    hsa-miR-320a hsa-miR-3607-3p hsa-miR-196a* hsa-miR-561 hsa-miR-622 hsa-miR-320d hsa-miR-146a* hsa-miR-320b
    SwitchGear 3'UTR luciferase reporter plasmidMYL12A 3' UTR sequence
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0035254glutamate receptor binding IEA--


    MYL12A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MYL12A:
     Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_Integrin-mediated cell adhesion and migration
    Cell adhesion_Integrin-mediated cell adhesion and migration1.00
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Cell adhesion Integrin-mediated cell adhesion and migration1.00
    Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases0.49
    2Immune response _CCR3 signaling in eosinophils
    Immune response _CCR3 signaling in eosinophils1.00
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils1.00
    3Cell adhesion Tight junctions
    Cell adhesion Tight junctions1.00
    Cell adhesion_Tight junctions0.99
    4Development MAG-dependent inhibition of neurite outgrowth
    Development MAG-dependent inhibition of neurite outgrowth1.00
    Development_MAG-dependent inhibition of neurite outgrowth0.87
    5Leukocyte transendothelial migration
    Leukocyte transendothelial migration1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 EMD Millipore Pathways for MYL12A
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils
    Development MAG-dependent inhibition of neurite outgrowth


    5/6 GeneGo (Thomson Reuters) Pathways for MYL12A (see all 6)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Tight junctions


    4         Kegg Pathways  (Kegg details for MYL12A):
        Focal adhesion
    Tight junction
    Leukocyte transendothelial migration
    Regulation of actin cytoskeleton


    MYL12A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYL12A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/112 Interacting proteins for MYL12A (P191052, 3 ENSP000002176524) via UniProtKB, MINT, STRING, and/or I2D (see all 112)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHUKO151112, 3, ENSP000003594244MINT-48063 I2D: score=2 STRING: ENSP00000359424
    ACTBP607092, 3, ENSP000003499604MINT-7899812 I2D: score=1 STRING: ENSP00000349960
    IKBKEQ141642, 3MINT-48126 I2D: score=3 
    IKBKGQ9Y6K92, 3MINT-48240 I2D: score=2 
    MAP3K3Q997592, 3MINT-48521 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008360regulation of cell shape IEA--
    GO:0072661protein targeting to plasma membrane IEA--


    MYL12A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MYL12A

    1 HMDB Compound for MYL12A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for MYL12A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about MYL12A / ML12A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYL12A gene: 
    NM_006471.2  

    Unigene Cluster for MYL12A:

    Myosin, light chain 12A, regulatory, non-sarcomeric
    Hs.190086  [show with all ESTs]
    Unigene Representative Sequence: AK057715
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000579226 ENST00000217652(uc002klr.3) ENST00000580353 ENST00000578611
    ENST00000585090 ENST00000583449 ENST00000578562 ENST00000577510 ENST00000580887
    ENST00000578038 ENST00000536605(uc002kls.3)

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    hsa-miR-320a hsa-miR-3607-3p hsa-miR-196a* hsa-miR-561 hsa-miR-622 hsa-miR-320d hsa-miR-146a* hsa-miR-320b
    SwitchGear 3'UTR luciferase reporter plasmidMYL12A 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK057715.1 AK222569.1 AK291145.1 BC016372.1 BC031972.1 BC032748.1 D82059.1 DQ185044.1 
    X54304.1 

    24/68 DOTS entries (see all 68):

    DT.86995292  DT.92469460  DT.92469476  DT.92059759  DT.100686941  DT.100673841  DT.92469540  DT.95278663 
    DT.97866616  DT.91808621  DT.450689  DT.92410215  DT.121084602  DT.91661473  DT.121084507  DT.92469528 
    DT.95278367  DT.121084548  DT.121084560  DT.121084565  DT.100686933  DT.92469415  DT.100673835  DT.91808025 

    24/2090 AceView cDNA sequences (see all 2090):

    BM764449 BM677646 D57686 BU619252 W74358 W42613 BE222598 CD367389 
    CA442040 BQ225863 CA417598 BM920173 BM741004 BI064190 BM785763 CF131034 
    CA412578 AI207827 BM977743 BM453343 CR590117 BM314890 CD368078 BU624100 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MYL12A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:        -     -     -                                 
    SP2:                                                      
    SP3:                    -                                 


    ECgene alternative splicing isoforms for MYL12A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYL12A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCTTAGCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MYL12A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYL12A

    SOURCE GeneReport for Unigene cluster: Hs.190086
        SABiosciences Custom PCR Arrays for MYL12A
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL12A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MYL12A gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves MYL12A1 myosin, light chain 12A, regulatory, non-sarcomeric 85.38(n)
    98.83(a)
      396284  NM_205341.3  NP_990672.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    97(a)
    possible ortholog
    4(42480830-42482809)
    zebrafish
    (Danio rerio)
    Actinopterygii myl12.21 myosin, light chain 12, genome duplicate 2 78.95(n)
    95.32(a)
      337084  NM_001130589.1  NP_001124061.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sqh1 spaghetti squash 74.51(n)
    82.35(a)
      31554  NM_078502.2  NP_511057.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mlc-41 Protein MLC-4 67.46(n)
    72.78(a)
      175440  NM_065299.3  NP_497700.1 
    rice
    (Oryza sativa)
    Liliopsida --
    OsCML9 - Calmodulin-related calcium sensor protein...
    26(a)
    possible ortholog
    5(24067532-24068539)


    ENSEMBL Gene Tree for MYL12A (if available)
    TreeFam Gene Tree for MYL12A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYL12A gene
    MYL72  MYL102  MYL92  MYL52  MYL22  MYLPF2  MYL12B2  
    18/21 SIMAP similar genes for MYL12A using alignment to 4 protein entries:     ML12A_HUMAN (see all proteins) (see all similar genes):
    MRLC3    MYL12B    MYL9    MYLPF    MYL2    MYL5
    MYL7    CALM2    CALM3    CALM1    CALML3    MYL10
    TNNC2    CALML4    TNNC1    CABP2    MYL6    CABP5

    MYL12A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MYL12A
    PGOHUM00000249747


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/230 NCBI SNPs in MYL12A are shown (see all 230    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1470290161,2
    --3245564(+) TTATCA/GAGATG 1 -- us2k10--------
    rs2011020541,2
    --3245572(+) TGCTA-/TTTTTT 1 -- us2k10--------
    rs713666491,2
    C,--3245577(+) TTTTTC/-CCACA 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs14431301,2
    C,F,A,--3245755(-) ATTCAG/CTGGGG 1 -- us2k17Minor allele frequency- C:0.11NA WA CSA EA 365
    rs38192251,2
    C,F,--3245828(-) CGAAGC/AGTAAA 1 -- us2k1 tfbs36Minor allele frequency- A:0.13NA WA EA 364
    rs1510109221,2
    --3245921(+) CTCCGC/TATTTT 1 -- us2k10--------
    rs1929082931,2
    --3246037(+) TAATAC/TCTGCT 1 -- us2k10--------
    rs99562221,2
    C,F,A,H,--3246064(+) GACAAA/GACAAT 1 -- us2k111Minor allele frequency- G:0.28NS NA WA CSA 1191
    rs1854701151,2
    --3246117(+) GAGGGA/GAAGAC 1 -- us2k10--------
    rs38192241,2
    C,F,--3246265(-) CTGCGC/TGGATG 1 -- us2k11Minor allele frequency- T:0.10EA 120

    HapMap Linkage Disequilibrium report for MYL12A (3247479 - 3256234 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MYL12A: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MYL12A for disorders           About GeneDecksing

    1 disease for MYL12A:    About MalaCards
    neuroblastoma

    1 disease from the University of Copenhagen DISEASES database for MYL12A:
    Familial hypertrophic cardiomyopathy

    Export disorders for MYL12A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYL12A gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with MYL12A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human nonsarcomeric 20,000 Da myosin regulatory light chain cDNA. (PubMed id 2216787)1, 2, 3 Grant J.W.... Church S.L. (1990)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    5. Sp1 phosphorylation by cyclin-dependent kinase 1/cycli n B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)1 Chuang J.Y....Hung J.J. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10627 HGNC: 16701 AceView: MRCL3andMRLC2 Ensembl:ENSG00000101608 euGenes: HUgn10627
    ECgene: MYL12A Kegg: 10627 H-InvDB: MYL12A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYL12A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYL12A gene:
    Search GeneIP for patents involving MYL12A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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