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MYL12A Gene

protein-coding GIFtS: 57
GCID: GC18P003238

Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric

(Previous names: myosin, light polypeptide, regulatory, non-sarcomeric (2...)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric¹ ²		MLC-2B² ³
Myosin, Light Polypeptide, Regulatory, Non-Sarcomeric (20kD)¹ ²		MLCB² ³
Myosin Regulatory Light Chain 3¹ ²		MRLC3² ³
Epididymis Secretory Protein Li 24² ³		MRCL3²
Myosin Regulatory Light Chain 2, Nonsarcomeric² ³		MYL2B²
Myosin Regulatory Light Chain MRLC3² ³		Myosin Regulatory Light Chain 12A²
Myosin RLC² ³		Myosin Regulatory Light Chain MRCL3²
HEL-S-24² ³		RLC³

External Ids:	HGNC: 16701¹	Entrez Gene: 10627²	Ensembl: ENSG00000101608⁷	UniProtKB: P19105³

Export aliases for MYL12A gene to outside databases

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYL12A Gene:

MYL12A (myosin, light chain 12A, regulatory, non-sarcomeric) is a protein-coding gene. GO annotations related to this gene include glutamate receptor binding and calcium ion binding. An important paralog of this gene is MYL10.

UniProtKB/Swiss-Prot: ML12A_HUMAN, P19105

Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle

cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell

locomotion (By similarity)

Gene Wiki entry for MYL12A (MRCL3) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000018.9 NT_010859.15 NC_018929.2

Regulatory elements:

Regulatory transcription factor binding sites in the MYL12A gene promoter:
Sox5 C/EBPbeta HNF-4alpha2 LCR-F1 HNF-4alpha1 FOXO4 FOXO1a Chx10 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MYL12A promoter sequence

Search Chromatin IP Primers for MYL12A

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYL12A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.31 Ensembl cytogenetic band: 18p11.31 HGNC cytogenetic band: 18p11.31

MYL12A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL12A gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P003238: view genomic region (about GC identifiers)

Start:	3,247,479 bp from pter	End:	3,256,234 bp from pter
Size:	8,756 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ML12A_HUMAN, P19105 (See protein sequence)

Recommended Name: Myosin regulatory light chain 12A

Size: 171 amino acids; 19794 Da

Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains

Miscellaneous: This chain binds calcium

Secondary accessions: Q53X45

Explore the universe of human proteins at neXtProt for MYL12A: NX_P19105

Explore proteomics data for MYL12A at MOPED

Post-translational modifications:

Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile

activity. It is required to generate the driving force in the migration of the cells but not necessary for

localization of myosin-2 at the leading edge (By similarity)¹

Ubiquitination² at Lys50, Lys149, Lys150

Modification sites at PhosphoSitePlus

See MYL12A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_006462.1

ENSEMBL proteins:

ENSP00000462171 ENSP00000217652 ENSP00000463614 ENSP00000462865 ENSP00000463009

ENSP00000464359 ENSP00000441231

MYL12A Human Recombinant Protein Products:

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	antibodies-online proteins for MYL12A (4 products)
	Search antibodies-online for peptides for MYL12A

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

EFHAND: EF-hand domain containing

MYL: Myosins / Light chain

3 InterPro protein domains:

IPR011992 EF-hand-dom_pair

IPR002048 EF_hand_dom

IPR018247 EF_Hand_1_Ca_BS

Graphical View of Domain Structure for InterPro Entry P19105

ProtoNet protein and cluster: P19105

UniProtKB/Swiss-Prot: ML12A_HUMAN, P19105

Similarity: Contains 3 EF-hand domains

Find genes that share domains with MYL12A About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: ML12A_HUMAN, P19105

Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle

cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell

locomotion (By similarity)

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	--
GO:0035254	glutamate receptor binding	IEA	--

Find genes that share ontologies with MYL12A About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for MYL12A:

Increased gamma-H2AX phosphory

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for MYL12A

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		Selected qRT-PCR Assays for microRNAs that regulate MYL12A (see all 13):
		hsa-miR-320a hsa-miR-3607-3p hsa-miR-196a* hsa-miR-561 hsa-miR-622 hsa-miR-320d hsa-miR-146a* hsa-miR-320b

		SwitchGear 3'UTR luciferase reporter plasmid: MYL12A 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MYL12A
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL12A

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	3
cytosol	3
mitochondrion	2
nucleus	2

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Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001725	stress fiber	IEA	--
GO:0016460	myosin II complex	IEA	--
GO:0030018	Z disc	IEA	--
GO:0043234	protein complex	--	--
GO:0070062	extracellular vesicular exosome	IDA	--

Find genes that share ontologies with MYL12A About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MYL12A About (see all 6)

See pathways by source

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SuperPath

Contained pathways About

Cell adhesion Integrin-mediated cell adhesion and migration

	Cell adhesion Integrin-mediated cell adhesion and migration	0.49			Development MAG-dependent inhibition of neurite outgrowth	0.42
	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases	0.49			Cell adhesion Tight junctions	0.32

Immune response CCR3 signaling in eosinophils

Inhibitory action of Lipoxins on neutrophil migration

0.51

Immune response CCR3 signaling in eosinophils

0.51

Focal adhesion

Focal adhesion

0.65

Regulation of actin cytoskeleton

Regulation of actin cytoskeleton

0.57

Tight junction

Tight junction

Find genes that share SuperPaths with MYL12A About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYL12A (see all 16)

	Activation of PKA through GPCR
	RhoA Pathway
	PKA Signaling
	Guidance Cues and Growth Cone Motility
	Antioxidant Action of Vitamin-C

Selected GeneGo (Thomson Reuters) Pathways for MYL12A (see all 6)

	Cell adhesion Integrin-mediated cell adhesion and migration
	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
	Inhibitory action of Lipoxins on neutrophil migration
	Immune response CCR3 signaling in eosinophils
	Cell adhesion Tight junctions

4 Kegg Pathways (Kegg details for MYL12A):

	Focal adhesion
	Tight junction
	Leukocyte transendothelial migration
	Regulation of actin cytoskeleton

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for MYL12A
Interactions:

Search GeneGlobe Interaction Network for MYL12A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for MYL12A (P19105^{1, 2, 3} ENSP00000217652⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 142)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CHUK	O15111²^,³, ENSP00000359424⁴	MINT-48063 I2D: score=2 STRING: ENSP00000359424
ACTB	P60709²^,³, ENSP00000349960⁴	MINT-7899812 I2D: score=1 STRING: ENSP00000349960
IKBKE	Q14164²^,³	MINT-48126 I2D: score=3
IKBKG	Q9Y6K9²^,³	MINT-48240 I2D: score=2
MAP3K3	Q99759²^,³	MINT-48521 I2D: score=2

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Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008360	regulation of cell shape	IEA	--
GO:0072661	protein targeting to plasma membrane	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for MYL12A (ML12A)

1 HMDB Compound for MYL12A About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

1 DrugBank Compound for MYL12A About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID	--	--	target	--	10592235

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MYL12A gene:

NM_006471.2

Unigene Cluster for MYL12A:

Myosin, light chain 12A, regulatory, non-sarcomeric

Hs.190086 [show with all ESTs]

Unigene Representative Sequence: AK057715

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000579226 ENST00000217652(uc002klr.3) ENST00000580353 ENST00000578611

ENST00000585090 ENST00000583449 ENST00000608786 ENST00000578562 ENST00000577510

ENST00000580887 ENST00000578038 ENST00000536605(uc002kls.3)

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		Selected qRT-PCR Assays for microRNAs that regulate MYL12A (see all 13):
		hsa-miR-320a hsa-miR-3607-3p hsa-miR-196a* hsa-miR-561 hsa-miR-622 hsa-miR-320d hsa-miR-146a* hsa-miR-320b

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		QuantiFast Probe-based Assays in human, mouse, rat MYL12A

Additional mRNA sequence:

AK057715.1 AK222569.1 AK291145.1 BC016372.1 BC031972.1 BC032748.1 D82059.1 DQ185044.1

X54304.1

Selected DOTS entries (see all 68):

DT.86995292 DT.92469460 DT.92469476 DT.92059759 DT.100686941 DT.100673841 DT.92469540 DT.95278663

DT.97866616 DT.91808621 DT.450689 DT.92410215 DT.121084602 DT.91661473 DT.121084507 DT.92469528

DT.95278367 DT.121084548 DT.121084560 DT.121084565 DT.100686933 DT.92469415 DT.100673835 DT.91808025

Selected AceView cDNA sequences (see all 2090):

BQ010305 AW002027 BQ772839 CB157507 CA417972 BI086527 BU902799 BX345631

CD369769 BI057174 BM842441 BM975089 CA307555 BI064082 AV714198 BQ775475

CF127911 BF742858 BQ582241 CD368287 BQ935838 BG028879 BQ073698 CB068622

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for MYL12A About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b
SP1:			-		-		-
SP2:
SP3:							-

ECgene alternative splicing isoforms for MYL12A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MYL12A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCCTTAGCTT

About this image

MYL12A expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 18) fully expand


Bone (Muscoskeletal System)
Bone Marrow

Colon (Gastrointestinal Tract)

Uterus (Reproductive System)

Thyroid (Endocrine System)

Testis (Reproductive System)

MYL12A Protein expression data from MOPED¹, PaxDb² and MaxQB³:

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MYL12A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.190086

Custom PCR Arrays for MYL12A

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL12A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for MYL12A gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Myl12a⁵ Myl12b¹	myosin, light chain 12A, regulatory, non-sarcomeric⁵ myosin, light chain 12B, regulatory¹	86.5(n)¹ 99.37(a)¹		17 (41.87 cM)⁵ 67938¹ NM_023402.2¹ NP_075891.1¹ 70993656⁵
chicken (Gallus gallus)	Aves	MYL12A⁶	Gallus gallus myosin, light chain 12A, regulatory,...	98(a)	many ↔ many	2(100543631-100550803)
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	71(a)	1 → many	GL343470.1(472422-472746)
zebrafish (Danio rerio)	Actinopterygii	myl12.1¹	myosin, light chain 12, genome duplicate 1	80.59(n) 93.04(a)		326719 NM_214699.1 NP_999864.1
fruit fly (Drosophila melanogaster)	Insecta	sqh⁶	spaghetti squash	80(a)	1 → many	X(6117094-6119196)
worm (Caenorhabditis elegans)	Secernentea	mlc-4⁶	Protein MLC-4 (mlc-4) mRNA, complete cds	72(a)	1 → many	III(3392013-3393787) WBGene00003372

ENSEMBL Gene Tree for MYL12A (if available)
TreeFam Gene Tree for MYL12A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for MYL12A gene

MYL10² MYL7² MYL9² MYL5² MYL2² MYLPF² MYL12B²

Selected SIMAP similar genes for MYL12A using alignment to 4 protein entries: ML12A_HUMAN (see all proteins) (see all similar genes):

MYL12B MYL9 MYLPF MYL5 MYL2 MYL7

CALM2 CALM1 CALM3 CALML3 MYL10 TNNC2

CALML4 TNNC1 CABP2 MYL6 CABP5 CALML5

Find genes that share paralogs with MYL12A About GenesLikeMe

1 Pseudogenes.org Pseudogene for MYL12A
PGOHUM00000249747

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147029016^1,2		--	3245564(+)	`TTATCA/GAGATG`	1	--	us2k¹		0	--	--	--	--
rs201102054^1,2		--	3245572(+)	`TGCTA-/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs35982350^1,2	C	--	3245577(+)	`TTTTTC/-CCACA`	1	--	us2k¹		1		NA	2
rs1443130^1,2	C,F,A	--	3245755(-)	`ATTCAG/CTGGGG`	1	--	us2k¹		7		NA WA CSA EA	365
rs3819225^1,2	C,F	--	3245828(-)	`CGAAGC/AGTAAA`	1	--	us2k¹ tfbs³		6		NA WA EA	364
rs151010922^1,2		--	3245921(+)	`CTCCGC/TATTTT`	1	--	us2k¹		0	--	--	--	--
rs192908293^1,2	C	--	3246037(+)	`TAATAC/TCTGCT`	1	--	us2k¹		0	--	--	--	--
rs9956222^1,2	C,F,A,H	--	3246064(+)	`GACAAA/GACAAT`	1	--	us2k¹		11		NS NA WA CSA	1191
rs185470115^1,2		--	3246117(+)	`GAGGGA/GAAGAC`	1	--	us2k¹		0	--	--	--	--
rs3819224^1,2	C,F	--	3246265(-)	`CTGCGC/TGGATG`	1	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for MYL12A (3247479 - 3256234 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for MYL12A: About this table

Variant ID	Type	Subtype	PubMed ID
esv275271	CNV	Loss	21479260
nsv909317	CNV	Gain	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 inferred disease relationship from the University of Copenhagen DISEASES database for MYL12A:

Familial hypertrophic cardiomyopathy

Find genes that share disorders with MYL12A About GenesLikeMe

Export disorders for MYL12A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MYL12A gene, integrated from 10 sources (see all 30):
(articles sorted by number of sources associating them with MYL12A)

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Human nonsarcomeric 20,000 Da myosin regulatory light chain cDNA. (PubMed id 2216787)^{1, 2, 3} Grant J.W.... Church S.L. (Nucleic Acids Res. 1990)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells. (PubMed id 11942626)^{1, 2} Iwasaki T.... Hosoya H. (Cell Struct. Funct. 2001)
A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)¹ Leng L....Wang J. (J. Proteome Res. 2014)
A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)¹ Weimann M.... Stelzl U. (Nat. Methods 2013)
Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)¹ Zanon A....Pichler I. (PLoS ONE 2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (Sci Signal 2012)
Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)¹ Chuang J.Y....Hung J.J. (Oncogene 2012)
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10627	HGNC: 16701	AceView: MRCL3andMRLC2	Ensembl:ENSG00000101608	euGenes: HUgn10627
ECgene: MYL12A	Kegg: 10627	H-InvDB: MYL12A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MYL12A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MYL12A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MYL12A gene:
Search GeneIP for patents involving MYL12A

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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MYL12A Gene

Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric

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MYL12A Gene

Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric

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