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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYL12A Gene

protein-coding   GIFtS: 56
GCID: GC18P003238

Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric

(Previous names: myosin, light polypeptide, regulatory, non-sarcomeric (2...)
  See related diseases
at
MalaCards
 

Aliases
for MYL12A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric1 2     MLCB2 3
Myosin, Light Polypeptide, Regulatory, Non-Sarcomeric (20kD)1 2     MRLC32 3
Myosin Regulatory Light Chain 31 2     MRCL32
Myosin Regulatory Light Chain 2, Nonsarcomeric2 3     MYL2B2
Myosin Regulatory Light Chain MRLC32 3     Myosin Regulatory Light Chain 12A2
Myosin RLC2 3     Myosin Regulatory Light Chain MRCL32
MLC-2B2 3     RLC3

External Ids:    HGNC: 167011   Entrez Gene: 106272   Ensembl: ENSG000001016087   UniProtKB: P191053   

Export aliases for MYL12A gene to outside databases


Summaries
for MYL12A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for MYL12A Gene: 
MYL12A (myosin, light chain 12A, regulatory, non-sarcomeric) is a protein-coding gene. Diseases associated with MYL12A include familial hypertrophic cardiomyopathy, and hypertrophic cardiomyopathy, and among its related super-pathways are Immune response CCR3 signaling in eosinophils and Cell adhesion Integrin-mediated cell adhesion and migration. GO annotations related to this gene include glutamate receptor binding and calcium ion binding. An important paralog of this gene is MYL10.

UniProtKB/Swiss-Prot: ML12A_HUMAN, P19105
Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle
cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell
locomotion (By similarity)

Gene Wiki entry for MYL12A (MRCL3) Gene


Genomic Views
for MYL12A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_010859.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYL12A gene promoter:
         Sox5   C/EBPbeta   HNF-4alpha2   LCR-F1   HNF-4alpha1   FOXO4   FOXO1a   Chx10   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MYL12A promoter sequence
   Search SABiosciences Chromatin IP Primers for MYL12A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYL12A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.31   Ensembl cytogenetic band:  18p11.31   HGNC cytogenetic band: 18p11.31

MYL12A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL12A gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P003238:  view genomic region     (about GC identifiers)

Start:
 3,247,479 bp from pter      End:
 3,256,234 bp from pter
Size:
 8,756 bases      Orientation:
 plus strand

Proteins
for MYL12A gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: ML12A_HUMAN, P19105 (See protein sequence)
Recommended Name: Myosin regulatory light chain 12A  
Size: 171 amino acids; 19794 Da
Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains
Miscellaneous: This chain binds calcium

Explore the universe of human proteins at neXtProt for MYL12A: NX_P19105

Explore proteomics data for MYL12A at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile
    activity. It is required to generate the driving force in the migration of the cells but not necessary for
    localization of myosin-2 at the leading edge (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P19105

    • MYL12A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MYL12A Protein Expression
    REFSEQ proteins: NP_006462.1  
    ENSEMBL proteins: 
     ENSP00000462171   ENSP00000217652   ENSP00000463614   ENSP00000462865   ENSP00000463009  
     ENSP00000464359   ENSP00000441231  

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    ProSpec Recombinant Protein for MYL12A
    Cloud-Clone Corp. Proteins for MYL12A 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IEA--
    GO:0016460myosin II complex IEA--
    GO:0030018Z disc IEA--
    GO:0043234protein complex ----

    MYL12A for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for MYL12A gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    EFHAND: EF-hand domain containing
    MYL: Myosins / Light chain

    3 InterPro protein domains:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P19105

    ProtoNet protein and cluster: P19105

    UniProtKB/Swiss-Prot: ML12A_HUMAN, P19105
    Similarity: Contains 3 EF-hand domains


    MYL12A for domains           About GeneDecksing


    Function
    for MYL12A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ML12A_HUMAN, P19105
    Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle
    cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell
    locomotion (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
    GO:0035254glutamate receptor binding IEA--
         
    MYL12A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MYL12A:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MYL12A 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYL12A 
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    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate MYL12A (see all 13):
    hsa-miR-320a hsa-miR-3607-3p hsa-miR-196a* hsa-miR-561 hsa-miR-622 hsa-miR-320d hsa-miR-146a* hsa-miR-320b
    SwitchGear 3'UTR luciferase reporter plasmid: MYL12A 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Pathways & Interactions
    for MYL12A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MYL12A About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response CCR3 signaling in eosinophils
    		Immune response CCR3 signaling in eosinophils0.51
    		Inhibitory action of Lipoxins on neutrophil migration0.51
    2Cell adhesion Integrin-mediated cell adhesion and migration
    		Cell adhesion Integrin-mediated cell adhesion and migration0.49
    		Cell adhesion Tight junctions0.33
    		Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    3Development MAG-dependent inhibition of neurite outgrowth
    		Development MAG-dependent inhibition of neurite outgrowth0.87
    4Focal Adhesion
    		Focal adhesion0.64
    5Regulation of Actin Cytoskeleton
    		Regulation of actin cytoskeleton0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for MYL12A
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils
    Development MAG-dependent inhibition of neurite outgrowth


    5/6 GeneGo (Thomson Reuters) Pathways for MYL12A (see all 6)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Tight junctions



    4         Kegg Pathways  (Kegg details for MYL12A):
        Focal adhesion
    Tight junction
    Leukocyte transendothelial migration
    Regulation of actin cytoskeleton


    MYL12A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYL12A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/112 Interacting proteins for MYL12A (P191052, 3 ENSP000002176524) via UniProtKB, MINT, STRING, and/or I2D (see all 112)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHUKO151112, 3, ENSP000003594244MINT-48063 I2D: score=2 STRING: ENSP00000359424
    ACTBP607092, 3, ENSP000003499604MINT-7899812 I2D: score=1 STRING: ENSP00000349960
    IKBKEQ141642, 3MINT-48126 I2D: score=3 
    IKBKGQ9Y6K92, 3MINT-48240 I2D: score=2 
    MAP3K3Q997592, 3MINT-48521 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008360regulation of cell shape IEA--
    GO:0072661protein targeting to plasma membrane IEA--

    MYL12A for ontologies           About GeneDecksing



    Drugs & Compounds
    for MYL12A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MYL12A (ML12A)

    1 HMDB Compound for MYL12A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for MYL12A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about MYL12A / ML12A

    Transcripts
    for MYL12A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MYL12A gene: 
    NM_006471.2  

    Unigene Cluster for MYL12A:

    Myosin, light chain 12A, regulatory, non-sarcomeric
    Hs.190086  [show with all ESTs]
    Unigene Representative Sequence: AK057715
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000579226 ENST00000217652(uc002klr.3) ENST00000580353 ENST00000578611
    ENST00000585090 ENST00000583449 ENST00000578562 ENST00000577510 ENST00000580887
    ENST00000578038 ENST00000536605(uc002kls.3)
    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate MYL12A (see all 13):
    hsa-miR-320a hsa-miR-3607-3p hsa-miR-196a* hsa-miR-561 hsa-miR-622 hsa-miR-320d hsa-miR-146a* hsa-miR-320b
    SwitchGear 3'UTR luciferase reporter plasmid: MYL12A 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional mRNA sequence: 

    AK057715.1 AK222569.1 AK291145.1 BC016372.1 BC031972.1 BC032748.1 D82059.1 DQ185044.1 
    X54304.1 

    24/68 DOTS entries (see all 68):

    DT.86995292  DT.92469460  DT.92469476  DT.92059759  DT.100686941  DT.100673841  DT.92469540  DT.95278663 
    DT.97866616  DT.91808621  DT.450689  DT.92410215  DT.121084602  DT.91661473  DT.121084507  DT.92469528 
    DT.95278367  DT.121084548  DT.121084560  DT.121084565  DT.100686933  DT.92469415  DT.100673835  DT.91808025 

    24/2090 AceView cDNA sequences (see all 2090):

    BM761577 CA310150 CR611530 CD366035 BQ632553 BM761951 CD369055 BM764869 
    CA412461 BQ226695 AW166330 BI064200 BM762242 BF820264 BM836152 CB122817 
    F28222 BM836031 BG878185 BG319610 BQ434059 AA377014 CA307916 BU752694 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MYL12A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:        -     -     -                                 
    SP2:                                                      
    SP3:                    -                                 


    ECgene alternative splicing isoforms for MYL12A

    Expression
    for MYL12A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYL12A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTTAGCTT
    MYL12A Expression
    About this image


    See MYL12A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYL12A

    SOURCE GeneReport for Unigene cluster: Hs.190086
        SABiosciences Custom PCR Arrays for MYL12A
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    In Situ
    Assay Products:     
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    Orthologs
    for MYL12A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MYL12A gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Myl12a1 , 5 myosin, light chain 12A, regulatory, non-sarcomeric1, 5 85.96(n)1
    98.25(a)1    		   17 (41.87 cM)5
    672681  NM_026064.21  NP_080340.21 
     709936565 
    chicken
    (Gallus gallus)    		 Aves MYL12A1 myosin, light chain 12A, regulatory, non-sarcomeric 85.38(n)
    98.83(a)    		   396284  NM_205341.3  NP_990672.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    MYL12A6
    		 Uncharacterized protein
    myosin, light chain 12A, regulatory, non-sarcomeri...
    		 97(a)
    71(a)
    		 possible ortholog
    1 ↔ 1
    		 4(42479416-42482824)
    GL343470.1(472422-472746)
    zebrafish
    (Danio rerio)    		 Actinopterygii myl12.21 myosin, light chain 12, genome duplicate 2 78.95(n)
    95.32(a)    		   337084  NM_001130589.1  NP_001124061.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta sqh1 spaghetti squash 74.51(n)
    82.35(a)    		   31554  NM_078502.2  NP_511057.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea mlc-41 Protein MLC-4 67.46(n)
    72.78(a)    		   175440  NM_065299.3  NP_497700.1 


    ENSEMBL Gene Tree for MYL12A (if available)
    TreeFam Gene Tree for MYL12A (if available)

    Paralogs
    for MYL12A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYL12A gene
    MYL102  MYL72  MYL92  MYL52  MYL22  MYLPF2  MYL12B2  
    18/21 SIMAP similar genes for MYL12A using alignment to 4 protein entries:     ML12A_HUMAN (see all proteins) (see all similar genes):
    MRLC3    MYL12B    MYL9    MYLPF    MYL2    MYL5
    MYL7    CALM2    CALM1    CALM3    CALML3    MYL10
    TNNC2    CALML4    TNNC1    CABP2    MYL6    CABP5

    MYL12A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MYL12A
    PGOHUM00000249747


    Genomic Variants
    for MYL12A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/272 SNPs in MYL12A are shown (see all 272)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1470290161,2
    		--3245564(+) TTATCA/GAGATG 1 -- us2k10--------
    rs2011020541,2
    		--3245572(+) TGCTA-/TTTTTT 1 -- us2k10--------
    rs359823501,2
    		C--3245577(+) TTTTTC/-CCACA 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs14431301,2
    		C,F,A--3245755(-) ATTCAG/CTGGGG 1 -- us2k17Minor allele frequency- C:0.11NA WA CSA EA 365
    rs38192251,2
    		C,F--3245828(-) CGAAGC/AGTAAA 1 -- us2k1 tfbs36Minor allele frequency- A:0.13NA WA EA 364
    rs1510109221,2
    		--3245921(+) CTCCGC/TATTTT 1 -- us2k10--------
    rs1929082931,2
    		C--3246037(+) TAATAC/TCTGCT 1 -- us2k10--------
    rs99562221,2
    		C,F,A,H--3246064(+) GACAAA/GACAAT 1 -- us2k111Minor allele frequency- G:0.28NS NA WA CSA 1191
    rs1854701151,2
    		--3246117(+) GAGGGA/GAAGAC 1 -- us2k10--------
    rs38192241,2
    		C,F--3246265(-) CTGCGC/TGGATG 1 -- us2k11Minor allele frequency- T:0.10EA 120

    HapMap Linkage Disequilibrium report for MYL12A (3247479 - 3256234 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MYL12A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv275271CNV Loss21479260
    nsv909317CNV Gain21882294

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    Disorders / Diseases
    for MYL12A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 2 diseases for MYL12A:    About MalaCards
    familial hypertrophic cardiomyopathy    hypertrophic cardiomyopathy

    1 disease from the University of Copenhagen DISEASES database for MYL12A:
    Familial hypertrophic cardiomyopathy

    MYL12A for disorders           About GeneDecksing


    Export disorders for MYL12A gene to outside databases

    Publications
    for MYL12A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYL12A gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with MYL12A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human nonsarcomeric 20,000 Da myosin regulatory light chain cDNA. (PubMed id 2216787)1, 2, 3 Grant J.W.... Church S.L. (1990)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    4. A Proteomics Strategy for the Identification of FAT10- Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    7. Sp1 phosphorylation by cyclin-dependent kinase 1/cycli n B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)1 Chuang J.Y....Hung J.J. (2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. Proteomic analysis of a4b1 integrin adhesion complexes reveals a-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (2012)

    External Searches for MYL12A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing MYL12A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10627 HGNC: 16701 AceView: MRCL3andMRLC2 Ensembl:ENSG00000101608 euGenes: HUgn10627
    ECgene: MYL12A Kegg: 10627 H-InvDB: MYL12A

    Other Databases showing MYL12A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MYL12A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYL12A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MYL12A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MYL12A gene:
    Search GeneIP for patents involving MYL12A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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