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Aliases for MYL12A Gene

Aliases for MYL12A Gene

  • Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric 2 3
  • Myosin, Light Polypeptide, Regulatory, Non-Sarcomeric (20kD) 2 3
  • Myosin Regulatory Light Chain 2, Nonsarcomeric 3 4
  • Myosin Regulatory Light Chain MRLC3 3 4
  • Epididymis Secretory Protein Li 24 3 4
  • Myosin Regulatory Light Chain 3 2 3
  • Myosin RLC 3 4
  • HEL-S-24 3 4
  • MLC-2B 3 4
  • MRLC3 3 4
  • MLCB 3 4
  • MRCL3 3
  • MYL2B 3
  • RLC 4

External Ids for MYL12A Gene

Summaries for MYL12A Gene

Entrez Gene Summary for MYL12A Gene

  • This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014]

GeneCards Summary for MYL12A Gene

MYL12A (Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Developmental Biology. GO annotations related to this gene include calcium ion binding and glutamate receptor binding. An important paralog of this gene is MYLPF.

UniProtKB/Swiss-Prot for MYL12A Gene

  • Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).

Gene Wiki entry for MYL12A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL12A Gene

Genomics for MYL12A Gene

Regulatory Elements for MYL12A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MYL12A Gene

Chromosome:
18
Start:
3,247,481 bp from pter
End:
3,256,237 bp from pter
Size:
8,757 bases
Orientation:
Plus strand

Genomic View for MYL12A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYL12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL12A Gene

Proteins for MYL12A Gene

  • Protein details for MYL12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19105-ML12A_HUMAN
    Recommended name:
    Myosin regulatory light chain 12A
    Protein Accession:
    P19105
    Secondary Accessions:
    • Q53X45

    Protein attributes for MYL12A Gene

    Size:
    171 amino acids
    Molecular mass:
    19794 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains
    Miscellaneous:
    • This chain binds calcium

neXtProt entry for MYL12A Gene

Proteomics data for MYL12A Gene at MOPED

Post-translational modifications for MYL12A Gene

  • Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYL12A Gene

Domains & Families for MYL12A Gene

Gene Families for MYL12A Gene

Protein Domains for MYL12A Gene

Graphical View of Domain Structure for InterPro Entry

P19105

UniProtKB/Swiss-Prot:

ML12A_HUMAN :
  • Contains 3 EF-hand domains.
Domain:
  • Contains 3 EF-hand domains.
genes like me logo Genes that share domains with MYL12A: view

Function for MYL12A Gene

Molecular function for MYL12A Gene

UniProtKB/Swiss-Prot Function:
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).

Gene Ontology (GO) - Molecular Function for MYL12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 21457715
GO:0035254 glutamate receptor binding --
genes like me logo Genes that share ontologies with MYL12A: view

Phenotypes for MYL12A Gene

GenomeRNAi human phenotypes for MYL12A:
genes like me logo Genes that share phenotypes with MYL12A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MYL12A Gene

Localization for MYL12A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYL12A Gene COMPARTMENTS Subcellular localization image for MYL12A gene
Compartment Confidence
extracellular 5
cytosol 4
cytoskeleton 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MYL12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber --
GO:0005829 cytosol TAS --
GO:0016459 myosin complex IEA --
GO:0016460 myosin II complex --
GO:0030018 Z disc --
genes like me logo Genes that share ontologies with MYL12A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYL12A Gene

Pathways & Interactions for MYL12A Gene

genes like me logo Genes that share pathways with MYL12A: view

Gene Ontology (GO) - Biological Process for MYL12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS --
GO:0007411 axon guidance TAS --
GO:0008360 regulation of cell shape --
GO:0048013 ephrin receptor signaling pathway TAS --
GO:0070527 platelet aggregation IMP 23382103
genes like me logo Genes that share ontologies with MYL12A: view

No data available for SIGNOR curated interactions for MYL12A Gene

Drugs & Compounds for MYL12A Gene

(2) Drugs for MYL12A Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID Experimental Pharma Target 0
Calcium Nutra 0
genes like me logo Genes that share compounds with MYL12A: view

Transcripts for MYL12A Gene

Unigene Clusters for MYL12A Gene

Myosin, light chain 12A, regulatory, non-sarcomeric:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYL12A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYL12A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - - -
SP2:
SP3: -

Relevant External Links for MYL12A Gene

GeneLoc Exon Structure for
MYL12A
ECgene alternative splicing isoforms for
MYL12A

Expression for MYL12A Gene

mRNA expression in normal human tissues for MYL12A Gene

mRNA differential expression in normal tissues according to GTEx for MYL12A Gene

This gene is overexpressed in Heart - Left Ventricle (x8.4), Whole Blood (x6.0), and Muscle - Skeletal (x5.5).

Protein differential expression in normal tissues from HIPED for MYL12A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.7), Ovary (11.3), and Monocytes (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYL12A Gene



SOURCE GeneReport for Unigene cluster for MYL12A Gene Hs.190086

genes like me logo Genes that share expression patterns with MYL12A: view

Protein tissue co-expression partners for MYL12A Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MYL12A Gene

Orthologs for MYL12A Gene

This gene was present in the common ancestor of animals.

Orthologs for MYL12A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYL12B 35
  • 89.47 (n)
  • 97.66 (a)
MYL9 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYL12B 35
  • 92.87 (n)
  • 98.74 (a)
-- 36
  • 91 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Myl12b 35
  • 86.5 (n)
  • 99.37 (a)
Myl12a 16
Myl12a 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYL12A 35
  • 99.42 (n)
  • 100 (a)
MYL12A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myl12b 35
  • 84.81 (n)
  • 99.37 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 94 (a)
OneToMany
chicken
(Gallus gallus)
Aves MYL12A 36
  • 98 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 71 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii myl12.1 35
  • 80.59 (n)
  • 93.04 (a)
myl12.1 36
  • 92 (a)
ManyToMany
myl12.2 36
  • 95 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta sqh 36
  • 80 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mlc-4 36
  • 72 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5063 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5139 36
  • 81 (a)
OneToMany
Species with no ortholog for MYL12A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MYL12A Gene

ENSEMBL:
Gene Tree for MYL12A (if available)
TreeFam:
Gene Tree for MYL12A (if available)

Paralogs for MYL12A Gene

Paralogs for MYL12A Gene

Pseudogenes.org Pseudogenes for MYL12A Gene

genes like me logo Genes that share paralogs with MYL12A: view

Variants for MYL12A Gene

Sequence variations from dbSNP and Humsavar for MYL12A Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs716351 -- 3,253,050(-) ATATA(A/G)CTAAC intron-variant
rs717183 -- 3,252,926(-) AGGGA(C/T)ACTAA intron-variant
rs1056088 -- 3,248,266(+) TGTCC(C/T)CCTGC intron-variant
rs1056089 -- 3,248,376(+) TTTTT(C/T)TTTAA intron-variant
rs1373001 -- 3,252,901(-) GTCCC(C/T)GCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYL12A Gene

Variant ID Type Subtype PubMed ID
nsv909317 CNV Gain 21882294
esv275271 CNV Loss 21479260

Variation tolerance for MYL12A Gene

Residual Variation Intolerance Score: 43.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYL12A Gene

HapMap Linkage Disequilibrium report
MYL12A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYL12A Gene

Disorders for MYL12A Gene

Relevant External Links for MYL12A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYL12A
genes like me logo Genes that share disorders with MYL12A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYL12A Gene

Publications for MYL12A Gene

  1. Human nonsarcomeric 20,000 Da myosin regulatory light chain cDNA. (PMID: 2216787) Grant J.W. … Church S.L. (Nucleic Acids Res. 1990) 2 67
  2. hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. (PMID: 25324306) Roy R. … Pardo O.E. (Nucleic Acids Res. 2014) 67
  3. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 67

Products for MYL12A Gene

Sources for MYL12A Gene

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