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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYL10 Gene

protein-coding   GIFtS: 48
GCID: GC07M101256

Myosin, Light Chain 10, Regulatory

  Search for MYL10
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Myosin, Light Chain 10, Regulatory1 2     PLRLC2 3
Myosin Light Chain 2, Lymphocyte-Specific2 3     Myosin Light Chain 2, Precursor Lymphocyte-Specific2
Precursor Lymphocyte-Specific Regulatory Light Chain2 3     Myosin Regulatory Light Chain 102
MYLC2PL2 3     

External Ids:    HGNC: 298251   Entrez Gene: 934082   Ensembl: ENSG000001064367   UniProtKB: Q9BUA63   

Export aliases for MYL10 gene to outside databases

Previous GC identifers: GC07M101044 GC07M095845


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MYL10 Gene: 
MYL10 (myosin, light chain 10, regulatory) is a protein-coding gene. Among its related super-pathways are Focal Adhesion and Regulation of Actin Cytoskeleton. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is MYL12A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYL10 gene promoter:
         TBP   Spz1   NF-1   AML1a   POU3F2   Cdc5   S8   HSF2   Pax-4a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MYL10 promoter sequence
   Search SABiosciences Chromatin IP Primers for MYL10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYL10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

MYL10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL10 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M101256:  view genomic region     (about GC identifiers)

Start:
101,256,605 bp from pter      End:
101,272,576 bp from pter
Size:
15,972 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 100,614,992-100,630,963     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MYL10_HUMAN, Q9BUA6 (See protein sequence)
Recommended Name: Myosin regulatory light chain 10  
Size: 226 amino acids; 25308 Da
Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains
Miscellaneous: This chain binds calcium (By similarity)

Explore the universe of human proteins at neXtProt for MYL10: NX_Q9BUA6

Explore proteomics data for MYL10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BUA6

  • MYL10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MYL10 Protein Expression
    REFSEQ proteins: NP_612412.2  
    ENSEMBL proteins: 
     ENSP00000223167  

    Human Recombinant Protein Products for MYL10: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for MYL10 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--

    MYL10 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing
    MYL: Myosins / Light chain

    3 InterPro protein domains:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q9BUA6

    ProtoNet protein and cluster: Q9BUA6

    UniProtKB/Swiss-Prot: MYL10_HUMAN, Q9BUA6
    Similarity: Contains 3 EF-hand domains


    MYL10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    MYL10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MYL10:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MYL10 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MYL10 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal adhesion0.64
    2Regulation of Actin Cytoskeleton
    Regulation of actin cytoskeleton0.57
    3Leukocyte transendothelial migration
    Leukocyte transendothelial migration
    4Tight junction
    Tight junction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4         Kegg Pathways  (Kegg details for MYL10):
        Focal adhesion
    Tight junction
    Leukocyte transendothelial migration
    Regulation of actin cytoskeleton


    MYL10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYL10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/18 Interacting proteins for MYL10 (ENSP000002231674) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBENSP000003499604STRING: ENSP00000349960
    ACTG1ENSP000003315144STRING: ENSP00000331514
    CGNENSP000002716364STRING: ENSP00000271636
    MYH10ENSP000002692434STRING: ENSP00000269243
    MYH14ENSP000004078794STRING: ENSP00000407879
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MYL10

    1 HMDB Compound for MYL10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about MYL10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYL10 gene: 
    NM_138403.4  

    Unigene Cluster for MYL10:

    Myosin, light chain 10, regulatory
    Hs.247831
    Unigene Representative Sequence: BC002778
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000223167(uc003uyr.3)
    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYL10
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYL10

    Additional mRNA sequence: BC002778.2 

    1 DOTS entry:

    DT.91845116 

    4 AceView cDNA sequences:

    BX283406 NM_138403 BC002778 BE387257 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYL10 expression in normal human tissues (normalized intensities)      MYL10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGGGGAGA
    MYL10 Expression
    About this image


    MYL10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             umbilical cord reticulocytes   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Umbilical Cord (Extraembryonic Tissues)
             umbilical cord reticulocytes   
     
     Oral Cavity (Gastrointestinal Tract)
             parotid gland   

    See MYL10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYL10

    SOURCE GeneReport for Unigene cluster: Hs.247831
        SABiosciences Custom PCR Arrays for MYL10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MYL10 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myl101 , 5 myosin, light chain 10, regulatory1, 5 88.44(n)1
    99.32(a)1
      5 (76.03 cM)5
    593101  NM_021611.21  NP_067624.21 
     1366931465 
    chicken
    (Gallus gallus)
    Aves MYL101 myosin, light chain 10, regulatory 77.03(n)
    85.98(a)
      417506  NM_001097526.1  NP_001090995.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    80(a)
    possible ortholog
    GL343613.1(241139-257530)
    zebrafish
    (Danio rerio)
    Actinopterygii idibd20252 idibd2025 79.77(n)   338131  AL924281.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mlc26
    CG330986
    --
    29(a)
    20(a)
    many ↔ many
    many ↔ many
    3R(25997160-26000273)
    3R(8212910-8214517)
    worm
    (Caenorhabditis elegans)
    Secernentea mlc-26
    mlc-16
    Myosin regulatory light chain 1
    45(a)
    45(a)
    many ↔ many
    many ↔ many
    X(17455779-17456594)
    X(17459160-17460767)


    ENSEMBL Gene Tree for MYL10 (if available)
    TreeFam Gene Tree for MYL10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYL10 gene
    MYL12A2  MYL72  MYL92  MYL52  MYL22  MYLPF2  MYL12B2  
    16 SIMAP similar genes for MYL10 using alignment to 1 protein entry:     MYL10_HUMAN:
    SNRPF    MYL2    MST132    MYL7    MYLPF    CALM1
    CALM2    CALM3    MYL5    CALML3    MRLC3    MYL12A
    MYL9    MYL12B    COQ5    MYL6

    MYL10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/431 SNPs in MYL10 are shown (see all 431)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1871189501,2
    --101256137(+) TATGAC/TCACAG 1 -- int10--------
    rs102154021,2
    C,A--101256140(+) gatcaC/Gagtta 1 -- int13Minor allele frequency- G:0.06WA NA 240
    rs1443369261,2
    --101256168(+) AAATCA/CTTGCC 1 -- int10--------
    rs1915455151,2
    --101256188(+) AACATC/TCCTTG 1 -- int10--------
    rs1487714971,2
    C--101256256(+) TCTCCC/TGTGCT 1 -- int10--------
    rs1450890571,2
    --101256447(+) TATCCC/TGTGGC 1 -- int10--------
    rs1820325891,2
    --101256648(+) CAACCA/GTAGGA 1 -- ut310--------
    rs1996381861,2
    --101256734(+) TGAATA/GTCGGG 1 -- ut310--------
    rs734134971,2
    C,F--101256736(+) AATGTC/TGGGGA 1 -- ut314Minor allele frequency- T:0.17WA CSA 126
    rs1860750371,2
    C--101256744(+) GGAGAC/TTTGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MYL10 (101256605 - 101272576 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MYL10:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831078CNV Loss17160897
    nsv888826CNV Loss21882294
    dgv7411n71CNV Gain21882294
    nsv888825CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MYL10 for disorders           About MalaCards

    MYL10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MYL10
    Human Genome Epidemiology (HuGE) Navigator: MYL10 (1 document)

    Export disorders for MYL10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYL10 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with MYL10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible. (PubMed id 1628631)1, 3, 9 Oltz E.M....Alt F.W. (1992)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    4. Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain en dothelial cells. (PubMed id 19794400)1 Zhong Y....Toborek M. (2010)
    5. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    10. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 93408 HGNC: 29825 AceView: MYLC2PL Ensembl:ENSG00000106436 euGenes: HUgn93408
    ECgene: MYL10 Kegg: 93408 H-InvDB: MYL10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYL10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYL10 gene:
    Search GeneIP for patents involving MYL10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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