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Aliases for MYL10 Gene

Aliases for MYL10 Gene

  • Myosin Light Chain 10 2 3 5
  • Precursor Lymphocyte-Specific Regulatory Light Chain 3 4
  • Myosin Light Chain 2, Lymphocyte-Specific 3 4
  • Myosin, Light Chain 10, Regulatory 2 3
  • MYLC2PL 3 4
  • PLRLC 3 4
  • Myosin Light Chain 2, Precursor Lymphocyte-Specific 3

External Ids for MYL10 Gene

Previous GeneCards Identifiers for MYL10 Gene

  • GC07M101044
  • GC07M101256
  • GC07M095845

Summaries for MYL10 Gene

GeneCards Summary for MYL10 Gene

MYL10 (Myosin Light Chain 10) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Regulation of actin cytoskeleton. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is MYLPF.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL10 Gene

Genomics for MYL10 Gene

Regulatory Elements for MYL10 Gene

Genomic Location for MYL10 Gene

Chromosome:
7
Start:
101,613,325 bp from pter
End:
101,629,296 bp from pter
Size:
15,972 bases
Orientation:
Minus strand

Genomic View for MYL10 Gene

Genes around MYL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL10 Gene

Proteins for MYL10 Gene

  • Protein details for MYL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUA6-MYL10_HUMAN
    Recommended name:
    Myosin regulatory light chain 10
    Protein Accession:
    Q9BUA6

    Protein attributes for MYL10 Gene

    Size:
    226 amino acids
    Molecular mass:
    25308 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains.
    Miscellaneous:
    • This chain binds calcium.

neXtProt entry for MYL10 Gene

Proteomics data for MYL10 Gene at MOPED

Post-translational modifications for MYL10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYL10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYL10 Gene

Domains & Families for MYL10 Gene

Gene Families for MYL10 Gene

Protein Domains for MYL10 Gene

Suggested Antigen Peptide Sequences for MYL10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUA6

UniProtKB/Swiss-Prot:

MYL10_HUMAN :
  • Contains 3 EF-hand domains.
Domain:
  • Contains 3 EF-hand domains.
genes like me logo Genes that share domains with MYL10: view

Function for MYL10 Gene

genes like me logo Genes that share phenotypes with MYL10: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYL10 Gene

Localization for MYL10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYL10 Gene COMPARTMENTS Subcellular localization image for MYL10 gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MYL10 Gene

Pathways & Interactions for MYL10 Gene

genes like me logo Genes that share pathways with MYL10: view

Pathways by source for MYL10 Gene

Interacting Proteins for MYL10 Gene

Gene Ontology (GO) - Biological Process for MYL10 Gene

None

No data available for SIGNOR curated interactions for MYL10 Gene

Drugs & Compounds for MYL10 Gene

(1) Drugs for MYL10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with MYL10: view

Transcripts for MYL10 Gene

mRNA/cDNA for MYL10 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYL10 Gene

Myosin, light chain 10, regulatory:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYL10 Gene

No ASD Table

Relevant External Links for MYL10 Gene

GeneLoc Exon Structure for
MYL10
ECgene alternative splicing isoforms for
MYL10

Expression for MYL10 Gene

mRNA expression in normal human tissues for MYL10 Gene

mRNA differential expression in normal tissues according to GTEx for MYL10 Gene

This gene is overexpressed in Muscle - Skeletal (x22.9) and Pituitary (x14.4).

Protein differential expression in normal tissues from HIPED for MYL10 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYL10 Gene



SOURCE GeneReport for Unigene cluster for MYL10 Gene Hs.247831

genes like me logo Genes that share expression patterns with MYL10: view

Protein tissue co-expression partners for MYL10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MYL10 Gene

Orthologs for MYL10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYL10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYL10 35
  • 90.08 (n)
  • 96.43 (a)
MYL10 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYL10 35
  • 89.76 (n)
  • 98.19 (a)
MYL10 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myl10 35
  • 88.44 (n)
  • 99.32 (a)
Myl10 16
Myl10 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYL10 35
  • 99.26 (n)
  • 100 (a)
MYL10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myl10 35
  • 79.44 (n)
  • 86.83 (a)
oppossum
(Monodelphis domestica)
Mammalia MYL10 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYL10 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYL10 35
  • 77.03 (n)
  • 85.98 (a)
MYL2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYL10 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myl10 35
  • 75.76 (n)
  • 83.03 (a)
zebrafish
(Danio rerio)
Actinopterygii idibd2025 35
myl10 35
  • 75.61 (n)
  • 75 (a)
myl10 36
  • 75 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2633 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10194 36
  • 57 (a)
ManyToMany
CSA.11077 36
  • 59 (a)
ManyToMany
Species with no ortholog for MYL10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYL10 Gene

ENSEMBL:
Gene Tree for MYL10 (if available)
TreeFam:
Gene Tree for MYL10 (if available)

Paralogs for MYL10 Gene

Paralogs for MYL10 Gene

(15) SIMAP similar genes for MYL10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MYL10: view

Variants for MYL10 Gene

Sequence variations from dbSNP and Humsavar for MYL10 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs12216595 - 101,624,206(+) CAAAC(A/G)TGGAG reference, missense
rs848644 -- 101,629,185(+) tgaag(C/T)gaaaa upstream-variant-2KB, utr-variant-5-prime
rs848645 -- 101,629,646(+) tcctc(C/T)gacca upstream-variant-2KB
rs848646 -- 101,630,321(+) TGAGT(C/G)CTCCT upstream-variant-2KB
rs848647 -- 101,630,948(+) GAGAC(A/G)TGAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MYL10 Gene

Variant ID Type Subtype PubMed ID
dgv7411n71 CNV Gain 21882294
nsv831078 CNV Loss 17160897
nsv888825 CNV Gain 21882294
nsv888826 CNV Loss 21882294

Variation tolerance for MYL10 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYL10 Gene

HapMap Linkage Disequilibrium report
MYL10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYL10 Gene

Disorders for MYL10 Gene

Relevant External Links for MYL10

Genetic Association Database (GAD)
MYL10
Human Genome Epidemiology (HuGE) Navigator
MYL10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYL10

No disorders were found for MYL10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYL10 Gene

Publications for MYL10 Gene

  1. A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible. (PMID: 1628631) Oltz E.M. … Alt F.W. (EMBO J. 1992) 2 3 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations. (PMID: 24528284) Ji Y. … Weinshilboum R.M. (Br J Clin Pharmacol 2014) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain endothelial cells. (PMID: 19794400) Zhong Y. … Toborek M. (J. Cereb. Blood Flow Metab. 2010) 3

Products for MYL10 Gene

Sources for MYL10 Gene

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