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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYL10 Gene

protein-coding   GIFtS: 50
GCID: GC07M101256

myosin, light chain 10, regulatory

 Explore 2 diseases affiliated with
MYL10 via our new
 Human Malady Compendium 
Biological research products
for MYL10
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Myosin, Light Chain 10, Regulatory1 2     Precursor Lymphocyte-Specific Regulatory Light Chain2 3
MYLC2PL1 2 3     MGC34791
PLRLC1 2 3     Myosin Light Chain 2, Precursor Lymphocyte-Specific2
Myosin Light Chain 2, Lymphocyte-Specific2 3     Myosin Regulatory Light Chain 102

External Ids:    HGNC: 298251   Entrez Gene: 934082   Ensembl: ENSG000001064367   UniProtKB: Q9BUA63   

Export aliases for MYL10 gene to outside databases

Previous GC identifers: GC07M101044 GC07M095845


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYL10 gene promoter:
         TBP   Spz1   NF-1   AML1a   POU3F2   Cdc5   S8   HSF2   Pax-4a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MYL10 promoter sequence
   Search SABiosciences Chromatin IP Primers for MYL10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYL10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

MYL10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL10 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M101256:  view genomic region     (about GC identifiers)

Start:
101,256,605 bp from pter      End:
101,272,576 bp from pter
Size:
15,972 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 100,614,992-100,630,963     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MYL10_HUMAN, Q9BUA6 (See protein sequence)
Recommended Name: Myosin regulatory light chain 10  
Size: 226 amino acids; 25308 Da
Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains
Miscellaneous: This chain binds calcium (By similarity)

Explore the universe of human proteins at neXtProt for MYL10: NX_Q9BUA6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BUA6

  • MYL10 Protein expression data from MOPED and PaxDb:    About this image 
    MYL10 Protein Expression
    REFSEQ proteins: NP_612412.2  
    ENSEMBL proteins: 
     ENSP00000223167  

    Human Recombinant Protein Products for MYL10: 
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    Novus Biologicals MYL10 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MYL10

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--

    MYL10 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MYL10


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MYL10 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR018247 EF_Hand_1_Ca_BS
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd

    Graphical View of Domain Structure for InterPro Entry Q9BUA6

    ProtoNet protein and cluster: Q9BUA6

    UniProtKB/Swiss-Prot: MYL10_HUMAN, Q9BUA6
    Similarity: Contains 3 EF-hand domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    MYL10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MYL10:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MYL10 

    miRNA
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Leukocyte transendothelial migration
    Leukocyte transendothelial migration1.00
    2Tight junction
    Tight junction1.00
    3Focal Adhesion
    Focal adhesion0.66
    4Regulation of Actin Cytoskeleton
    Regulation of actin cytoskeleton0.58

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    4         Kegg Pathways  (Kegg details for MYL10):
        Focal adhesion
    Tight junction
    Leukocyte transendothelial migration
    Regulation of actin cytoskeleton


    MYL10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYL10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/18 Interacting proteins for MYL10 (ENSP000002231674) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBENSP000003499604STRING: ENSP00000349960
    ACTG1ENSP000003315144STRING: ENSP00000331514
    CGNENSP000002716364STRING: ENSP00000271636
    MYH10ENSP000002692434STRING: ENSP00000269243
    MYH14ENSP000004078794STRING: ENSP00000407879
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MYL10

    1 HMDB Compound for MYL10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about MYL10 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYL10 gene: 
    NM_138403.4  

    Unigene Cluster for MYL10:

    Myosin, light chain 10, regulatory
    Hs.247831
    Unigene Representative Sequence: BC002778
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000223167(uc003uyr.3)

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MYL10
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYL10
    OriGene shRNA RFP: MYL10
    OriGene siRNA: MYL10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYL10
    Sirion Biotech Custom design and validation of potent shRNA sequences against MYL10 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYL10 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: MYL10 (NM_138403)
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    Primer
    Products:
        
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYL10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYL10

    Additional cDNA sequence: BC002778.2 

    1 DOTS entry:

    DT.91845116 

    4 AceView cDNA sequences:

    NM_138403 BX283406 BC002778 BE387257 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYL10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTGGGGAGA
    MYL10 Expression
    About this image

    MYL10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    HyStem+TGF?3+GDF5-induced 7PEND24 cells (HyStem+TGF?3+GDF5 in...)Bone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MYL10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYL10

    SOURCE GeneReport for Unigene cluster: Hs.247831
        SABiosciences Custom PCR Arrays for MYL10
    Primer
    Products:
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MYL10 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves MYL101 myosin, light chain 10, regulatory 77.03(n)
    85.98(a)
      417506  NM_001097526.1  NP_001090995.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYL106
    --
    67(a)
    1 ↔ 1
    GL343613.1(244606-256698)
    zebrafish
    (Danio rerio)
    Actinopterygii idibd20252 idibd2025 79.77(n)   338131  AL924281.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mlc26
    Eip63F-16
    (see all 3)
    Ecdysone-induced protein 63F 1
    (see all 3)
    27(a)
    19(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    3R(25997160-26000273)
    3L(3909973-3935617)
    worm
    (Caenorhabditis elegans)
    Secernentea mlc-16
    mlc-26
    Myosin regulatory light chain 2
    42(a)
    42(a)
    many ↔ many
    many ↔ many
    X(17459086-17460693)
    X(17455705-17456520)
    rice
    (Oryza sativa)
    Liliopsida --
    OsCML9 - Calmodulin-related calcium sensor protein...
    23(a)
    possible ortholog
    5(24067532-24068539)


    ENSEMBL Gene Tree for MYL10 (if available)
    TreeFam Gene Tree for MYL10 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYL10 gene
    MYL12A2  MYL72  MYL92  MYL52  MYL22  MYLPF2  MYL12B2  
    17 SIMAP similar genes for MYL10 using alignment to 1 protein entry:     MYL10_HUMAN:
    SNRPF    NCKAP1L    MYL2    MST132    MYL7    MYLPF
    CALM1    CALM2    CALM3    MYL5    CALML3    MRLC3
    MYL12A    MYL9    MYL12B    COQ5    MYL6

    MYL10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/345 NCBI SNPs in MYL10 are shown (see all 345    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1871189501,2
    --101256137(+) TATGAC/TCACAG 1 -- int10--------
    rs102154021,2
    C,A--101256140(+) GATCAC/GAGTTA 1 -- int13Minor allele frequency- G:0.06WA NA 240
    rs1443369261,2
    --101256168(+) AAATCA/CTTGCC 1 -- int10--------
    rs1915455151,2
    --101256188(+) AACATC/TCCTTG 1 -- int10--------
    rs1487714971,2
    --101256256(+) TCTCCC/TGTGCT 1 -- int10--------
    rs1450890571,2
    --101256447(+) TATCCC/TGTGGC 1 -- int10--------
    rs1820325891,2
    --101256648(+) CAACCA/GTAGGA 1 -- ut310--------
    rs1996381861,2
    --101256734(+) TGAATA/GTCGGG 1 -- ut310--------
    rs734134971,2
    C,F--101256736(+) AATGTC/TGGGGA 1 -- ut314Minor allele frequency- T:0.17WA CSA 126
    rs1860750371,2
    C--101256744(+) GGAGAC/TTTGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MYL10 (101256605 - 101272576 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for MYL10
         2 CNVs: 4551 4552

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MYL10 for disorders           About GeneDecksing

    2 diseases for MYL10:    About MalaCards
    hermaphroditism    pharyngitis

    Human Genome Epidemiology (HuGE) Navigator: MYL10 (1 document)

    Export disorders for MYL10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYL10 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with MYL10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible. (PubMed id 1628631)1, 3, 9 Oltz E.M....Alt F.W. (1992)
    2. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    3. Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain en dothelial cells. (PubMed id 19794400)1 Zhong Y....Toborek M. (2010)
    4. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    5. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    10. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 93408 HGNC: 29825 AceView: MYLC2PL Ensembl:ENSG00000106436 euGenes: HUgn93408
    ECgene: MYL10 Kegg: 93408 H-InvDB: MYL10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYL10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYL10 gene:
    Search GeneIP for patents involving MYL10

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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    VWF
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    von Willebrand factor
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