MYL10 Gene
protein-coding GIFtS : 50
GCID: GC07 M101256
myosin, light chain 10, regulatory
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Aliasesfor MYL10 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Myosin, Light Chain 10, Regulatory 1 2 Precursor Lymphocyte-Specific Regulatory Light Chain2 3 MYLC2PL1 2 3 MGC34791 PLRLC1 2 3 Myosin Light Chain 2, Precursor Lymphocyte-Specific2 Myosin Light Chain 2, Lymphocyte-Specific2 3 Myosin Regulatory Light Chain 102
Export aliases for MYL10 gene to outside databases Previous GC identifers: GC07M101044 GC07M095845
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Summariesfor MYL10 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor MYL10 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MYL10 gene promoter: TBP Spz1 NF-1 AML1a POU3F2 Cdc5 S8 HSF2 Pax-4a RSRFC4 Other transcription factors Search SABiosciences Chromatin IP Primers for MYL10 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYL10
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22.1 MYL10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07M101256: view genomic region
(about GC identifiers )
Start:
101,256,605 bp from pter
End:
101,272,576 bp from pter
Size:
15,972 bases
Orientation:
minus strand
1 alternative location : Chr 7-,CRA_TCAG 100,614,992-100,630,963
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Proteinsfor MYL10 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MYL10_HUMAN, Q9BUA6 (See
protein sequence )Recommended Name: Myosin regulatory light chain 10 Size : 226 amino acids; 25308 Da
Subunit : Myosin is a hexamer of 2 heavy chains and 4 light chains
Miscellaneous : This chain binds calcium (By similarity)Explore the universe of human proteins at neXtProt for MYL10: NX_Q9BUA6 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9BUA6 MYL10 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_612412.2 ENSEMBL proteins: ENSP00000223167 Human Recombinant Protein Products for MYL10: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005739 mitochondrion
IDA --
MYL10 for ontologies About GeneDecksing MYL10 Antibody Products: Assay Products for MYL10:
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Protein
Domains / Familiesfor MYL10 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MYL10 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9BUA6 ProtoNet protein and cluster: Q9BUA6
UniProtKB/Swiss-Prot: MYL10_HUMAN, Q9BUA6 Similarity : Contains 3 EF-hand domains
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Functionfor MYL10 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005509 calcium ion binding
IEA --
MYL10 for ontologies About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for MYL10 :Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MYL10 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MYL10 (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MYL10 (NM_138403 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYL10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MYL10
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL10
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Pathways & Interactionsfor MYL10 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Leukocyte transendothelial migration 2 Tight junction 3 Focal Adhesion 4 Regulation of Actin Cytoskeleton
Pathway sources See GeneCards unified pathways Show all pathways 4
Kegg Pathways (Kegg details for MYL10) :
MYL10 for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYL10 STRING Interaction
Network Preview (showing 5 interactants - click image to see 18)5/18 Interacting proteins for MYL10 (ENSP00000223167 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 18 )About this table
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Drugs & Compoundsfor MYL10 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for MYL10 1 HMDB Compound for MYL10 About this table Search CenterWatch for drugs/clinical trials and news about MYL10
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Transcriptsfor MYL10 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MYL10 gene: NM_138403.4 Unigene Cluster for MYL10:
Myosin, light chain 10, regulatory Hs.247831 Unigene Representative Sequence: BC002778 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000223167 (uc003uyr.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MYL10 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MYL10 (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MYL10 (NM_138403 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYL10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MYL10
Additional cDNA sequence: BC002778.2
1 DOTS entry : DT.91845116
4 AceView cDNA sequences :
NM_138403 BX283406 BC002778 BE387257 GeneLoc Exon Structure
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Expression for MYL10 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MYL10 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTTGGGGAGAAbout this image MYL10 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
Stem Cell Differentiation: 1 LifeMap Cell Name Category HyStem+TGF?3+GDF5-induced 7PEND24 cells (HyStem+TGF?3+GDF5 in... )Bone Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See MYL10 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MYL10 SOURCE GeneReport for Unigene cluster: Hs.247831 SABiosciences Custom PCR Arrays for MYL10 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MYL10Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat MYL10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MYL10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MYL10 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL10
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Orthologsfor MYL10 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for MYL10 gene from 6/21 species (see all 21 ) About this table
ENSEMBL Gene Tree for MYL10 (if available)TreeFam Gene Tree for MYL10 (if available)
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Paralogsfor MYL10 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MYL10 gene MYL12A 2 MYL7 2 MYL9 2 MYL5 2 MYL2 2 MYLPF 2 MYL12B 2 17 SIMAP similar genes for MYL10 using alignment to 1 protein entry: MYL10_HUMAN :SNRPF NCKAP1L MYL2 MST132 MYL7 MYLPF CALM1 CALM2 CALM3 MYL5 CALML3 MRLC3 MYL12A MYL9 MYL12B COQ5 MYL6
MYL10 for paralogs About GeneDecksing
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Genomic Variantsfor MYL10 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 7 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MYL10 (101256605 - 101272576 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for MYL10 2 CNVs : 4551 4552
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MYL10
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Disorders
/ Diseasesfor MYL10 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MYL10 for disorders About GeneDecksing 2 diseases for MYL10 : About MalaCards hermaphroditism pharyngitis Human Genome Epidemiology (HuGE) Navigator: MYL10 (1 document)Export disorders for MYL10 gene to outside databases
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Publicationsfor MYL10 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MYL10 gene, integrated from 9 sources (see all 11 ): (articles sorted by number of sources associating them with MYL10) Utopia : connect your pdf to the dynamic world of online information
A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible. (PubMed id 1628631) 1 , 3, 9 Oltz E.M....Alt F.W. (1992) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain en dothelial cells. (PubMed id 19794400) 1 Zhong Y....Toborek M. (2010) Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624) 1 Hendrickson S.L....O'Brien S.J. (2010) The LIFEdb database in 2006. (PubMed id 16381901) 1 Mehrle A....Wiemann S. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336) 1 Wiemann S....Poustka A. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000) Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614) 1 Simpson J.C.... Wiemann S. (2000)
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External Searches for MYL10 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MYL10 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MYL10 gene
(According to HUGE )
About This Section --
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Specialized Databases showing MYL10 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for MYL10 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MYL10 gene: Search GeneIP for patents involving MYL10 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MYL10 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for MYL10 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for MYL10 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MYL10 OriGene Protein Over-expression Lysate for MYL10 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MYL10 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MYL10 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MYL10 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MYL10 OriGene Custom Protein Services for MYL10 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MYL10 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MYL10 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYL10 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MYL10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MYL10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MYL10
Search Tocris compounds for MYL10
MYL10 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL10
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MYL10
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