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Aliases for MYL10 Gene

Aliases for MYL10 Gene

  • Myosin, Light Chain 10, Regulatory 2 3
  • Precursor Lymphocyte-Specific Regulatory Light Chain 3 4
  • Myosin Light Chain 2, Lymphocyte-Specific 3 4
  • MYLC2PL 3 4
  • PLRLC 3 4
  • Myosin Light Chain 2, Precursor Lymphocyte-Specific 3
  • Myosin Regulatory Light Chain 10 3

External Ids for MYL10 Gene

Previous GeneCards Identifiers for MYL10 Gene

  • GC07M101044
  • GC07M101256
  • GC07M095845

Summaries for MYL10 Gene

GeneCards Summary for MYL10 Gene

MYL10 (Myosin, Light Chain 10, Regulatory) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Focal adhesion. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is MYL12A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL10 Gene

Genomics for MYL10 Gene

Regulatory Elements for MYL10 Gene

Genomic Location for MYL10 Gene

101,613,325 bp from pter
101,629,296 bp from pter
15,972 bases
Minus strand

Genomic View for MYL10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL10 Gene

Proteins for MYL10 Gene

  • Protein details for MYL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myosin regulatory light chain 10
    Protein Accession:
    Secondary Accessions:

    Protein attributes for MYL10 Gene

    226 amino acids
    Molecular mass:
    25308 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains
    • This chain binds calcium.

neXtProt entry for MYL10 Gene

Proteomics data for MYL10 Gene at MOPED

Post-translational modifications for MYL10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYL10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYL10 Gene

Domains for MYL10 Gene

Gene Families for MYL10 Gene

Protein Domains for MYL10 Gene

Suggested Antigen Peptide Sequences for MYL10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 EF-hand domains.
  • Contains 3 EF-hand domains.
genes like me logo Genes that share domains with MYL10: view

Function for MYL10 Gene

Gene Ontology (GO) - Molecular Function for MYL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with MYL10: view

Phenotypes for MYL10 Gene

GenomeRNAi human phenotypes for MYL10:
genes like me logo Genes that share phenotypes with MYL10: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYL10

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYL10 Gene

Localization for MYL10 Gene

Subcellular locations from

Jensen Localization Image for MYL10 Gene COMPARTMENTS Subcellular localization image for MYL10 gene
Compartment Confidence
mitochondrion 4
cytoskeleton 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MYL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MYL10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYL10 Gene

Pathways for MYL10 Gene

genes like me logo Genes that share pathways with MYL10: view

Pathways by source for MYL10 Gene

Interacting Proteins for MYL10 Gene

Gene Ontology (GO) - Biological Process for MYL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS --
genes like me logo Genes that share ontologies with MYL10: view

Drugs for MYL10 Gene

(1) HMDB Compounds for MYL10 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with MYL10: view

Transcripts for MYL10 Gene

mRNA/cDNA for MYL10 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYL10 Gene

Myosin, light chain 10, regulatory:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYL10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYL10 Gene

No ASD Table

Relevant External Links for MYL10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYL10 Gene

mRNA expression in normal human tissues for MYL10 Gene

mRNA differential expression in normal tissues according to GTEx for MYL10 Gene

This gene is overexpressed in Muscle - Skeletal (22.9) and Pituitary (14.4).

Protein differential expression in normal tissues for MYL10 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYL10 Gene

SOURCE GeneReport for Unigene cluster for MYL10 Gene Hs.247831

genes like me logo Genes that share expressions with MYL10: view

Expression partners for MYL10 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MYL10 Gene

Orthologs for MYL10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYL10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MYL10 35
  • 90.08 (n)
  • 96.43 (a)
MYL10 36
  • 96 (a)
(Canis familiaris)
Mammalia MYL10 35
  • 89.76 (n)
  • 98.19 (a)
MYL10 36
  • 98 (a)
(Mus musculus)
Mammalia Myl10 35
  • 88.44 (n)
  • 99.32 (a)
Myl10 16
Myl10 36
  • 99 (a)
(Pan troglodytes)
Mammalia MYL10 35
  • 99.26 (n)
  • 100 (a)
MYL10 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Myl10 35
  • 79.44 (n)
  • 86.83 (a)
(Monodelphis domestica)
Mammalia MYL10 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia MYL10 36
  • 73 (a)
(Gallus gallus)
Aves MYL10 35
  • 77.03 (n)
  • 85.98 (a)
MYL2 36
  • 85 (a)
(Anolis carolinensis)
Reptilia MYL10 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia myl10 35
  • 75.76 (n)
  • 83.03 (a)
(Danio rerio)
Actinopterygii idibd2025 35
myl10 35
  • 75.61 (n)
  • 75 (a)
myl10 36
  • 75 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2633 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10194 36
  • 57 (a)
CSA.11077 36
  • 59 (a)
Species with no ortholog for MYL10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYL10 Gene

Gene Tree for MYL10 (if available)
Gene Tree for MYL10 (if available)

Paralogs for MYL10 Gene

Paralogs for MYL10 Gene

(15) SIMAP similar genes for MYL10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MYL10: view

Variants for MYL10 Gene

Sequence variations from dbSNP and Humsavar for MYL10 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs740199 -- 101,615,601(+) CCCCC(A/C/G)CTAGC intron-variant
rs740200 -- 101,616,535(-) AATAT(A/G)TATAT intron-variant
rs848644 -- 101,629,185(+) tgaag(C/T)gaaaa utr-variant-5-prime
rs848645 -- 101,629,646(+) tcctc(C/T)gacca upstream-variant-2KB
rs848646 -- 101,630,321(+) TGAGT(C/G)CTCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MYL10 Gene

Variant ID Type Subtype PubMed ID
dgv7411n71 CNV Gain 21882294
nsv831078 CNV Loss 17160897
nsv888825 CNV Gain 21882294
nsv888826 CNV Loss 21882294

Relevant External Links for MYL10 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYL10 Gene

Disorders for MYL10 Gene

Relevant External Links for MYL10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MYL10 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MYL10 Gene

Publications for MYL10 Gene

  1. A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible. (PMID: 1628631) Oltz E.M. … Alt F.W. (EMBO J. 1992) 2 3 23
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations. (PMID: 24528284) Ji Y. … Weinshilboum R.M. (Br J Clin Pharmacol 2014) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for MYL10 Gene

Sources for MYL10 Gene

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