Set Analyses:
GeneALaCart
GeneDecks
VarElect
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 


MYL1 Gene

protein-coding   GIFtS: 63
GCID: GC02M211118

Myosin, Light Chain 1, Alkali; Skeletal, Fast

(Previous names: myosin, light polypeptide 1, alkali; skeletal, fast)
  See related diseases
at
MalaCards
 

Aliases
for MYL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus
Aliases
Myosin, Light Chain 1, Alkali; Skeletal, Fast1 2     MLC1F2
Myosin, Light Polypeptide 1, Alkali; Skeletal, Fast1 2     MLC3F2
Myosin Light Chain A1/A22 3     A1 Catalytic2
Myosin Light Chain Alkali 1/22 3     A2 Catalytic2
MLC1/MLC32 3     Myosin Light Chain 1/3, Skeletal Muscle Isoform2
MLC1F/MLC3F2 3     

External Ids:    HGNC: 75821   Entrez Gene: 46322   Ensembl: ENSG000001685307   OMIM: 1607805   UniProtKB: P059763   

Export aliases for MYL1 gene to outside databases

Previous GC identifers: GC02M209430 GC02M209879 GC02M211357 GC02M210980 GC02M210863 GC02M203000


Summaries
for MYL1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus
Entrez Gene summary for MYL1 Gene:
Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable
alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light
chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for MYL1 Gene:
MYL1 (myosin, light chain 1, alkali; skeletal, fast) is a protein-coding gene. Diseases associated with MYL1 include rhabdomyosarcoma, and laryngitis. GO annotations related to this gene include structural constituent of muscle and calcium ion binding. An important paralog of this gene is MYL4.

UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976
Function: Regulatory light chain of myosin. Does not bind calcium

summary for MYL1 Gene:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYL1 Gene


Genomic Views
for MYL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYL1 gene promoter:
         ER-alpha   STAT2   STAT1beta   c-Myb   Tal-1beta   STAT1alpha   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MYL1 promoter sequence
   Search Chromatin IP Primers for MYL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33-q34   Ensembl cytogenetic band:  2q34   HGNC cytogenetic band: 2q33-q34

MYL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M211118:  view genomic region     (about GC identifiers)

Start:
 211,154,868 bp from pter      End:
 211,179,914 bp from pter
Size:
 25,047 bases      Orientation:
 minus strand

Proteins
for MYL1 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus
UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976 (See protein sequence)
Recommended Name: Myosin light chain 1/3, skeletal muscle isoform  
Size: 194 amino acids; 21145 Da
Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains
Secondary accessions: B2R4N6 B2R4T6 P06741 Q6IBD5
Alternative splicing: 2 isoforms:  P05976-1   P05976-2, P06741-1   (Initiator Met-1 is removed. Contains a N-acetylalanine at position 2 (By similarity))

Explore the universe of human proteins at neXtProt for MYL1: NX_P05976

Explore proteomics data for MYL1 at MOPED

Post-translational modifications: 

  • Isoform MLC3 is acetylated at position 2 (By similarity)1
  • Ubiquitination2 at Lys141
  • Modification sites at PhosphoSitePlus

    • See MYL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_524144.1  NP_524146.1  

    ENSEMBL proteins: 
     ENSP00000343321   ENSP00000307280  
    Reactome Protein details: P05976

    MYL1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MYL1
    OriGene Protein Over-expression Lysate for MYL1
    OriGene MassSpec for MYL1
    OriGene Custom Protein Services for MYL1
    GenScript Custom Purified and Recombinant Proteins Services for MYL1
    Novus Biologicals MYL1 Proteins
    Novus Biologicals MYL1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MYL1
    Cloud-Clone Corp. Proteins for MYL1

    MYL1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MYL1
    Novus Biologicals MYL1 Antibodies
    Abcam antibodies for MYL1 (Q9Y623, Q14324, P11055, P06741, P05976, P60660, P12882)
    Cloud-Clone Corp. Antibodies for MYL1
    ThermoFisher Antibody for MYL1
    LSBio Antibodies in human, mouse, rat for MYL1

    MYL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MYL1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MYL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MYL1
    Cloud-Clone Corp. CLIAs for MYL1

    Domains /
    Families
    for MYL1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    EFHAND: EF-hand domain containing
    MYL: Myosins / Light chain

    2 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom

    Graphical View of Domain Structure for InterPro Entry P05976

    ProtoNet protein and cluster: P05976

    UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976
    Similarity: Contains 3 EF-hand domains


    MYL1 for domains           About GeneDecksing


    Function
    for MYL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYL1_HUMAN, P05976
    Function: Regulatory light chain of myosin. Does not bind calcium

         Genatlas biochemistry entry for MYL1:
    myosin,light polypeptide 1,alkali;skeletal,fast,same as MLC1-F & MLC3-F

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0008307structural constituent of muscle NAS3904738
         
    MYL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MYL1:
     Increased G1 DNA content 

         9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Myl1):
     behavior/neurological  cellular  embryogenesis  growth/size/body  mortality/aging 
     muscle  nervous system  normal  skeleton 

    MYL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Myl1tm1Nros for MYL1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYL1

    miRNA
    Products:            		Block miRNA regulation of human, mouse, rat MYL1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MYL1
    SwitchGear 3'UTR luciferase reporter plasmid: MYL1 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for MYL1
    Predesigned siRNA for gene silencing in human, mouse, rat MYL1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MYL1

    Clone
    Products:             		 OriGene clones in human, mouse for MYL1 (see all 14)
    OriGene ORF clones in mouse, rat for MYL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MYL1 (NM_079422)
    Sino Biological Human cDNA Clone for MYL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYL1

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MYL1
    Browse ESI BIO Cell Lines and PureStem Progenitors for MYL1 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL1


    Localization
    for MYL1 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    extracellular1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005859muscle myosin complex NAS3904738
    GO:0030016myofibril IDA8145163
    GO:0030017sarcomere NAS3904738
    GO:0043292contractile fiber ----

    MYL1 for ontologies           About GeneDecksing


    Pathways & Interactions
    for MYL1 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus
    SuperPaths for MYL1 About   (see all 17)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Striated Muscle Contraction
    		Striated Muscle Contraction0.82
    		Muscle contraction0.61
    		Striated Muscle Contraction0.82
    2Immune response CCR3 signaling in eosinophils
    		Inhibitory action of Lipoxins on neutrophil migration0.51
    		Immune response CCR3 signaling in eosinophils0.51
    3Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA0.77
    		Activation of PKA through GPCR0.71
    		cAMP Pathway0.77
    		PKA Signaling0.56
    4Cell adhesion Integrin mediated cell adhesion and migration
    		Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    		Development MAG dependent inhibition of neurite outgrowth0.46
    		Cell adhesion Integrin mediated cell adhesion and migration0.49
    		Cell adhesion Tight junctions0.33
    5PAK Pathway
    		PAK Pathway0.56
    		Epithelial Adherens Junctions0.36
    		Antioxidant Action of Vitamin-C0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYL1 (see all 16)
        Activation of PKA through GPCR
    RhoA Pathway
    PKA Signaling
    Guidance Cues and Growth Cone Motility
    Antioxidant Action of Vitamin-C

    8 GeneGo (Thomson Reuters) Pathways for MYL1 (see first 5)
        Signal transduction Activation of PKC via G-Protein coupled receptor
    Cell adhesion Integrin-mediated cell adhesion and migration
    Inhibitory action of Lipoxins on neutrophil migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Cell adhesion Tight junctions
    Development MAG-dependent inhibition of neurite outgrowth

    4 BioSystems Pathways for MYL1
        G13 Signaling Pathway
    Regulation of Actin Cytoskeleton
    Striated Muscle Contraction
    Endothelin


    1 Reactome Pathway for MYL1
        Striated Muscle Contraction



    MYL1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYL1
    Interactions:

        Search GeneGlobe Interaction Network for MYL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYL1 (P059763 ENSP000003072804) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPB41P111713, ENSP000002901004I2D: score=1 STRING: ENSP00000290100
    ACTA1P681333, ENSP000003556454I2D: score=1 STRING: ENSP00000355645
    ACTA2P627363, ENSP000002247844I2D: score=1 STRING: ENSP00000224784
    IL7RP168713I2D: score=1 
    SLC2A4P146723I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction IDA8145163
    GO:0007517muscle organ development ----
    GO:0030049muscle filament sliding TAS--
    GO:0060048cardiac muscle contraction IEA--

    MYL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MYL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MYL1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BTSSelective inhibitor of skeletal muscle myosin II ATPase activity[1576-37-0]
    (R)-(+)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)[1177356-70-5]
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)[856925-71-8]
    (+-)-BlebbistatinSelective inhibitor of myosin II ATPase activity[674289-55-5]

    1 HMDB Compound for MYL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    Transcripts
    for MYL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus
    REFSEQ mRNAs for MYL1 gene (2 alternative transcripts): 
    NM_079420.2  NM_079422.2  

    Unigene Cluster for MYL1:

    Myosin, light chain 1, alkali; skeletal, fast
    Hs.187338  [show with all ESTs]
    Unigene Representative Sequence: BF790783
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341685(uc002veb.3) ENST00000352451(uc002vec.3) ENST00000496436
    ENST00000484290
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat MYL1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MYL1
    SwitchGear 3'UTR luciferase reporter plasmid: MYL1 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for MYL1
    Predesigned siRNA for gene silencing in human, mouse, rat MYL1
    Clone
    Products:             		 OriGene clones in human, mouse for MYL1 (see all 14)
    OriGene ORF clones in mouse, rat for MYL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MYL1 (NM_079422)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYL1
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for MYL1
    OriGene qSTAR qPCR primer pairs in human, mouse for MYL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYL1
      QuantiTect SYBR Green Assays in human, mouse, rat MYL1
      QuantiFast Probe-based Assays in human, mouse, rat MYL1

    Additional mRNA sequence: 

    AK311892.1 AK311942.1 BC005318.1 CR456869.1 M20643.1 X05451.1 

    11 DOTS entries:

    DT.451890  DT.100646912  DT.95136953  DT.120988964  DT.92458835  DT.100646906  DT.87046784  DT.100028901 
    DT.120988967  DT.120988980  DT.92012066 

    Selected AceView cDNA sequences (see all 414):

    F28438 W84453 F19305 AA993535 BU735911 F25010 AA176940 BM667508 
    BM678600 CR598137 F30560 BF475776 F29303 F35530 F31356 F32732 
    BM720926 BM667558 BM678556 W67183 F30858 F31527 F27414 AA332405 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MYL1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                                        
    SP2:                    -     -     -                                       
    SP3:              -     -     -     -     -     -     -                     
    SP4:                          -                                             


    ECgene alternative splicing isoforms for MYL1

    Expression
    for MYL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MYL1 expression in normal human tissues (normalized intensities)      MYL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCAACAAA
    MYL1 Expression
    About this image


    MYL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cardiomyocytes Atrial Septum
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Long Bone
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    MYL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    MYL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.187338
        Custom PCR Arrays for MYL1
    Primer
    Products:    		OriGene qPCR primer pairs and template standards for MYL1
    OriGene qSTAR qPCR primer pairs in human, mouse for MYL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYL1
    QuantiTect SYBR Green Assays in human, mouse, rat MYL1
    QuantiFast Probe-based Assays in human, mouse, rat MYL1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL1

    Orthologs
    for MYL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYL1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Myl11 , 5 myosin, light polypeptide 11, 5 88.54(n)1
    93.75(a)1    		   1 (33.71 cM)5
    179011  NM_021285.31  NP_067260.11 
     669242955 
    chicken
    (Gallus gallus)    		 Aves MYL11 myosin, light chain 1, alkali; skeletal, fast 78.89(n)
    80.67(a)    		   396470  NM_001044632.1  NP_001038097.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MYL16
    		 myosin, light chain 1, alkali; skeletal, fast
    		 86(a)
    		 1 ↔ 1
    		 1(113465920-113497825)
    African clawed frog
    (Xenopus laevis)    		 Amphibia myl1-prov2 myosin light chain, alkali, fast skeletal muscle 79.94(n)    L38596.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii myl11 myosin, light chain 1, alkali; skeletal, fast 67.3(n)
    63.52(a)    		   336165  NM_200000.1  NP_956294.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Mlc-c3 myosin ATPase 53(a)   5A8   --
    worm
    (Caenorhabditis elegans)    		 Secernentea T12D8.63 EF hand 48(a)   III(13694513-13695376)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes MLC11 MLC1 50.25(n)
    38.97(a)    		   852772   NP_011409.1 


    ENSEMBL Gene Tree for MYL1 (if available)
    TreeFam Gene Tree for MYL1 (if available)

    Paralogs
    for MYL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MYL1 gene
    MYL42  MYL6B2  MYL62  MYL32  
    18 SIMAP similar genes for MYL1 using alignment to 3 protein entries:     MYL1_HUMAN (see all proteins):
    MYL6    MYL3    MYL4    MYL6B    CALML3    CALM3
    CALM1    CALM2    CETN2    CABP1    CETN1    TNNC2
    CALML5    TNNC1    EFCAB2    CABP2    CALML6    CETN3

    MYL1 for paralogs           About GeneDecksing



    Genomic Variants
    for MYL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Selected SNPs for MYL1 (see all 596)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1837718571,2
    		--211154446(+) CCATCA/CCAGAG 2 -- ds50010--------
    rs1905540361,2
    		--211154559(+) ATTGTC/TACTAG 2 -- ds50010--------
    rs130202321,2
    		C,F,H--211154625(+) GTTTTC/TGCTTT 2 -- ds500113Minor allele frequency- T:0.07NS EA NA WA 1056
    rs1822277871,2
    		C--211154753(+) GTAGAC/TTTCAG 2 -- ds50010--------
    rs1867702861,2
    		--211154989(+) TTCTCA/TTCTAG 2 -- ut310--------
    rs1916936021,2
    		--211155050(+) GAAGAC/TGTATA 2 -- ut310--------
    rs1814848991,2
    		--211155085(+) TGAACC/TGTCCA 2 -- ut310--------
    rs758797361,2
    		F--211155308(+) CACTTA/GCAAGA 2 -- int11Minor allele frequency- G:0.01WA 118
    rs766711231,2
    		C,F--211155321(+) AGCCAA/GTTCCT 2 -- int11Minor allele frequency- G:0.04WA 118
    rs1154803461,2
    		F--211155648(+) ATCTCG/ATAATT 2 -- int11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for MYL1 (211154868 - 211179914 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MYL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834520CNV Loss17160897
    nsv875767CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYL1
    DNA2.0 Custom Variant and Variant Library Synthesis for MYL1

    Disorders / Diseases
    for MYL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 OMIM gene information: 160780    OMIM disorders: --

    6 diseases for MYL1:    About MalaCards
    rhabdomyosarcoma    laryngitis    influenza    ischemia
    hiv-1    endotheliitis


    MYL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MYL1

    Export disorders for MYL1 gene to outside databases

    Publications
    for MYL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus
    PubMed articles for MYL1 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with MYL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. (PubMed id 2304459)1, 3 Hailstones D.L. and Gunning P.W. (Mol. Cell. Biol. 1990)
    3. Identification of the functional promoter regions in the human gene encoding the myosin alkali light chains MLC1 and MLC3 of fast skeletal muscle. (PubMed id 2777779)1, 2 Seidel U. and Arnold H.H. (J. Biol. Chem. 1989)
    4. Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter. (PubMed id 3422212)1, 3 Cohen-Haguenauer O....FrAczal J. (Hum. Genet. 1988)
    5. Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms. (PubMed id 2458299)1, 2 Seidel U.... Arnold H.H. (Gene 1988)
    6. The complete nucleotide sequences of cDNA clones coding for human myosin light chains 1 and 3. (PubMed id 3601661)1, 2 Seidel U.... Arnold H.H. (Nucleic Acids Res. 1987)
    7. The MLK-related kinase (MRK) is a novel RhoC effector that mediates lysophosphatidic acid (LPA)-stimulated tumor cell invasion. (PubMed id 23319595)1 Korkina O....Ruggieri R. (J. Biol. Chem. 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    External Searches for MYL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MYL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4632 HGNC: 7582 AceView: MYL1 Ensembl:ENSG00000168530 euGenes: HUgn4632
    ECgene: MYL1 H-InvDB: MYL1

    Other Databases showing MYL1 gene

    (According to HUGE)
    About This Section

    TryGeneCards Plus    		   --

    Specialized Databases showing MYL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MYL1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MYL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for MYL1 gene:
    Search GeneIP for patents involving MYL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MYL1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MYL1  
     OriGene qPCR primer pairs and template standards for MYL1   OriGene Protein Over-expression Lysate for MYL1  
     OriGene MassSpec something-or-other for MYL1   OriGene clones in human, mouse for MYL1  
     OriGene qSTAR qPCR primer pairs in human, mouse for MYL1   OriGene Purified Protein for MYL1  
     OriGene ORF clones in mouse, rat for MYL1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MYL1   OriGene Custom Protein Services for MYL1  

         		 
     Block miRNA regulation of human, mouse, rat MYL1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MYL1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYL1 Predesigned siRNA for gene silencing in human, mouse, rat MYL1
     QuantiFast Probe-based Assays in human, mouse, rat MYL1 QuantiTect SYBR Green Assays in human, mouse, rat MYL1
     Custom PCR Arrays for MYL1 Search Chromatin IP Primers for MYL1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYL1  Search GeneGlobe Interaction Network for MYL1
     Regulatory tfbs in MYL1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MYL1 GenScript cDNA clones with any tag delivered in your preferred vector for MYL1
     GenScript Custom Assay Services for MYL1 GenScript Custom overexpressing Cell Line Services for MYL1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for MYL1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for MYL1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MYL1 antibodies
     MYL1 proteins
     MYL1 lysates
     Antibodies for MYL1
     See all of Abcam's Antibodies, Kits and Proteins for MYL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for MYL1
     Proteins for MYL1
     Antibodies for MYL1
     ELISAs for MYL1
     CLIAs for MYL1



     Browse ESI BIO Cell Lines and PureStem Progenitors for MYL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL1
     SwitchGear 3'UTR luciferase reporter plasmids for MYL1
     SwitchGear Promoter luciferase reporter plasmids for MYL1
     ThermoFisher Antibody for MYL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYL1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYL1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYL1
     LSBio Antibodies in human, mouse, rat for MYL1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      MYL1 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4