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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MYL1 Gene

protein-coding GIFtS: 63
GCID: GC02M211118

Myosin, Light Chain 1, Alkali; Skeletal, Fast

(Previous names: myosin, light polypeptide 1, alkali; skeletal, fast)

4 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Myosin, Light Chain 1, Alkali; Skeletal, Fast¹ ²		MLC1F²
Myosin, Light Polypeptide 1, Alkali; Skeletal, Fast¹ ²		MLC3F²
Myosin Light Chain A1/A2² ³		A1 Catalytic²
Myosin Light Chain Alkali 1/2² ³		A2 Catalytic²
MLC1/MLC3² ³		Myosin Light Chain 1/3, Skeletal Muscle Isoform²
MLC1F/MLC3F² ³

External Ids:	HGNC: 7582¹	Entrez Gene: 4632²	Ensembl: ENSG00000168530⁷	OMIM: 160780⁵	UniProtKB: P05976³

Export aliases for MYL1 gene to outside databases

Previous GC identifers: GC02M209430 GC02M209879 GC02M211357 GC02M210980 GC02M210863 GC02M203000

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYL1 Gene:

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali

light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain

expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. (provided by RefSeq,

Jul 2008)

GeneCards Summary for MYL1 Gene:

MYL1 (myosin, light chain 1, alkali; skeletal, fast) is a protein-coding gene. Diseases associated with MYL1 include rhabdomyosarcoma, and influenza, and among its related super-pathways are Striated Muscle Contraction and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include structural constituent of muscle and calcium ion binding. An important paralog of this gene is MYL4.

UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976

Function: Regulatory light chain of myosin. Does not bind calcium

summary for MYL1 Gene:

Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding

and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),

almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain

that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts

with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory

myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.

Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is

involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a

contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by

intracellular Ca2+ concentrations.

Gene Wiki entry for MYL1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.2 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MYL1 gene promoter:
ER-alpha STAT2 STAT1beta c-Myb Tal-1beta STAT1alpha E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MYL1 promoter sequence

Search SABiosciences Chromatin IP Primers for MYL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33-q34 Ensembl cytogenetic band: 2q34 HGNC cytogenetic band: 2q33-q34

MYL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M211118: view genomic region (about GC identifiers)

Start:	211,154,868 bp from pter	End:	211,179,914 bp from pter
Size:	25,047 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976 (See protein sequence)

Recommended Name: Myosin light chain 1/3, skeletal muscle isoform

Size: 194 amino acids; 21145 Da

Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains

Secondary accessions: B2R4N6 B2R4T6 P06741 Q6IBD5

Alternative splicing: 2 isoforms: P05976-1 P05976-2, P06741-1 (Initiator Met-1 is removed. Contains a N-acetylalanine at position 2 (By similarity))

Explore the universe of human proteins at neXtProt for MYL1: NX_P05976

Explore proteomics data for MYL1 at MOPED

Post-translational modifications:

UniProtKB: Isoform MLC3 is acetylated at position 2 (By similarity)

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P05976

MYL1 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_524144.1 NP_524146.1

ENSEMBL proteins:

ENSP00000343321 ENSP00000307280

Reactome Protein details: P05976
Human Recombinant Protein Products for MYL1:

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Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0005859	muscle myosin complex	NAS	3904738
GO:0030016	myofibril	IDA	8145163
GO:0030017	sarcomere	NAS	3904738
GO:0043292	contractile fiber	--	--

MYL1 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

EFHAND: EF-hand domain containing

MYL: Myosins / Light chain

2 InterPro protein domains:

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_dom

Graphical View of Domain Structure for InterPro Entry P05976

ProtoNet protein and cluster: P05976

UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976

Similarity: Contains 3 EF-hand domains

MYL1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MYL1_HUMAN, P05976

Function: Regulatory light chain of myosin. Does not bind calcium

Genatlas biochemistry entry for MYL1:

myosin,light polypeptide 1,alkali;skeletal,fast,same as MLC1-F & MLC3-F

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0008307	structural constituent of muscle	NAS	3904738

MYL1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for MYL1:

Increased G1 DNA content

9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Myl1):

behavior/neurological	cellular	embryogenesis	growth/size	mortality/aging
muscle	nervous system	normal	skeleton

MYL1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Myl1^tm1Nros for MYL1

inGenious Targeting Laboratory - Custom generated mouse model solutions for MYL1

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MYL1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for MYL1 About (see all 18)

See pathways by source

SuperPath

Contained pathways About

Striated Muscle Contraction

	Striated Muscle Contraction	0.87			Muscle contraction	0.65
	Striated Muscle Contraction	0.87

Immune response CCR3 signaling in eosinophils

Immune response CCR3 signaling in eosinophils

0.51

Inhibitory action of Lipoxins on neutrophil migration

0.51

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	0.77			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

PAK Pathway

	PAK Pathway	0.56			Epithelial Adherens Junctions	0.36
	Antioxidant Action of Vitamin-C	0.56

Cell adhesion Integrin-mediated cell adhesion and migration

	Cell adhesion Integrin-mediated cell adhesion and migration	0.49			Cell adhesion Tight junctions	0.33
	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases	0.49

Pathways by source See SuperPaths
Show all pathways

5/7 EMD Millipore Pathways for MYL1 (see all 7)

	Cell adhesion Integrin-mediated cell adhesion and migration
	Cell adhesion Tight junctions
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
	Immune response CCR3 signaling in eosinophils

5/16 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYL1 (see all 16)

	Activation of PKA through GPCR
	RhoA Pathway
	PKA Signaling
	Guidance Cues and Growth Cone Motility
	Antioxidant Action of Vitamin-C

8 GeneGo (Thomson Reuters) Pathways for MYL1 (see first 5)

	Signal transduction Activation of PKC via G-Protein coupled receptor
	Cell adhesion Integrin-mediated cell adhesion and migration
	Inhibitory action of Lipoxins on neutrophil migration
	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
	Immune response CCR3 signaling in eosinophils
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Cell adhesion Tight junctions
	Development MAG-dependent inhibition of neurite outgrowth

4 BioSystems Pathways for MYL1

	G13 Signaling Pathway
	Regulation of Actin Cytoskeleton
	Striated Muscle Contraction
	Endothelin

2 Reactome Pathways for MYL1

	Muscle contraction
	Striated Muscle Contraction

MYL1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MYL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/50 Interacting proteins for MYL1 (P05976³ ENSP00000307280⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 50)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EPB41	P11171³, ENSP00000290100⁴	I2D: score=1 STRING: ENSP00000290100
ACTA1	P68133³, ENSP00000355645⁴	I2D: score=1 STRING: ENSP00000355645
ACTA2	P62736³, ENSP00000224784⁴	I2D: score=1 STRING: ENSP00000224784
IL7R	P16871³	I2D: score=1
SLC2A4	P14672³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006936	muscle contraction	IDA	8145163
GO:0007517	muscle organ development	NAS	--
GO:0030049	muscle filament sliding	TAS	--
GO:0060048	cardiac muscle contraction	IEA	--

MYL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for MYL1 available from Tocris Bioscience About this table

Compound	Action	CAS #
BTS	Selective inhibitor of skeletal muscle myosin II ATPase activity	[1576-37-0]
(R)-(+)-Blebbistatin	Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)	[1177356-70-5]
(S)-(-)-Blebbistatin	Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)	[856925-71-8]
(+-)-Blebbistatin	Selective inhibitor of myosin II ATPase activity	[674289-55-5]

1 HMDB Compound for MYL1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about MYL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MYL1 gene (2 alternative transcripts):

NM_079420.2 NM_079422.2

Unigene Cluster for MYL1:

Myosin, light chain 1, alkali; skeletal, fast

Hs.187338 [show with all ESTs]

Unigene Representative Sequence: BF790783

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000341685(uc002veb.3) ENST00000352451(uc002vec.3) ENST00000496436

ENST00000484290

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Additional mRNA sequence:

AK311892.1 AK311942.1 BC005318.1 CR456869.1 M20643.1 X05451.1

11 DOTS entries:

DT.451890 DT.100646912 DT.95136953 DT.120988964 DT.92458835 DT.100646906 DT.87046784 DT.100028901

DT.120988967 DT.120988980 DT.92012066

24/414 AceView cDNA sequences (see all 414):

CR598137 F28438 F35245 BM720926 W92584 F30858 F25010 BM697229

F31880 AA176940 AL598940 F29303 BU735911 F34766 BF589612 AU099573

F35530 F27414 F30560 F32732 F29961 BM678556 BU581245 N69926

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for MYL1 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b
SP1:
SP2:							-		-		-
SP3:					-		-		-		-		-		-		-
SP4:									-

ECgene alternative splicing isoforms for MYL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MYL1 expression in normal human tissues (normalized intensities) MYL1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AATCAACAAA

About this image

MYL1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/10 selected tissues (see all 10) fully expand


Limb (Muscoskeletal System) fully expand to see all 6 entries
Mesenchymal Condensate Cells Zeugopod
Zeugopod
limb/hindlimb/leg

Skeletal Muscle (Muscoskeletal System) fully expand to see all 6 entries
cavities and their linings/intraembryonic coelom/diaphragm

Gut Tube (Gastrointestinal Tract) fully expand to see all 2 entries
Foregut Endoderm Cells Foregut
Foregut

Bone (Muscoskeletal System) fully expand to see all 2 entries
Mesenchymal Condensate Cells Zeugopod
Zeugopod Long Bone

Heart (Cardiovascular System) fully expand to see all 2 entries
Cardiomyocytes Atrial Septum

See MYL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MYL1

SOURCE GeneReport for Unigene cluster: Hs.187338

SABiosciences Custom PCR Arrays for MYL1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYL1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYL1 gene from 8/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Myl1^{1 , 5}	myosin, light polypeptide 1^{1, 5}	87.94(n)¹ 94.15(a)¹		1 (33.71 cM)⁵ 17901¹ NM_021285.3¹ NP_067260.1¹ 66924295⁵
chicken (Gallus gallus)	Aves	MYL1¹	myosin, light chain 1, alkali; skeletal, fast	78.89(n) 80.67(a)		396470 NM_001044632.1 NP_001038097.1
lizard (Anolis carolinensis)	Reptilia	MYL1⁶	Uncharacterized protein	84(a)	1 ↔ 1	1(113465920-113497825)
African clawed frog (Xenopus laevis)	Amphibia	myl1-prov²	myosin light chain, alkali, fast skeletal muscle	79.94(n)		L38596.1
zebrafish (Danio rerio)	Actinopterygii	myl1¹	myosin, light chain 1, alkali; skeletal, fast	66.67(n) 64.74(a)		336165 NM_200000.1 NP_956294.1
fruit fly (Drosophila melanogaster)	Insecta	Mlc-c³	myosin ATPase	53(a)		5A8 --
worm (Caenorhabditis elegans)	Secernentea	T12D8.6³ mlc-3¹	EF hand³ Protein MLC-3¹	48(a)³ 53.66(n)¹ 45.39(a)¹		III(13694513-13695376)³ 175768¹ NM_171128.6¹ NP_741145.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	MLC1¹	Mlc1p	50.49(n) 38.97(a)		852772 NP_011409.1

ENSEMBL Gene Tree for MYL1 (if available)
TreeFam Gene Tree for MYL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MYL1 gene

MYL4² MYL6B² MYL6² MYL3²

18 SIMAP similar genes for MYL1 using alignment to 3 protein entries: MYL1_HUMAN (see all proteins):

MYL6 MYL3 MYL4 MYL6B CALML3 CALM3

CALM1 CALM2 CETN2 CABP1 CETN1 TNNC2

CALML5 TNNC1 EFCAB2 CABP2 CALML6 CETN3

MYL1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183771857^1,2		--	211154446(+)	`CCATCA/CCAGAG`	2	--	ds500¹		0	--	--	--	--
rs190554036^1,2		--	211154559(+)	`ATTGTC/TACTAG`	2	--	ds500¹		0	--	--	--	--
rs13020232^1,2	C,F,H	--	211154625(+)	`GTTTTC/TGCTTT`	2	--	ds500¹		13		NS EA NA WA	1056
rs182227787^1,2	C	--	211154753(+)	`GTAGAC/TTTCAG`	2	--	ds500¹		0	--	--	--	--
rs186770286^1,2		--	211154989(+)	`TTCTCA/TTCTAG`	2	--	ut3¹		0	--	--	--	--
rs191693602^1,2		--	211155050(+)	`GAAGAC/TGTATA`	2	--	ut3¹		0	--	--	--	--
rs181484899^1,2		--	211155085(+)	`TGAACC/TGTCCA`	2	--	ut3¹		0	--	--	--	--
rs75879736^1,2	F	--	211155308(+)	`CACTTA/GCAAGA`	2	--	int¹		1		WA	118
rs76671123^1,2	C,F	--	211155321(+)	`AGCCAA/GTTCCT`	2	--	int¹		1		WA	118
rs115480346^1,2	F	--	211155648(+)	`ATCTCG/ATAATT`	2	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for MYL1 (211154868 - 211179914 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for MYL1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv834520	CNV	Loss	17160897
nsv875767	CNV	Gain	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MYL1 for disorders           About GeneDecksing

OMIM gene information: 160780    OMIM disorders: --

4 diseases for MYL1:    About MalaCards

rhabdomyosarcoma influenza laryngitis ischemia

Genetic Association Database (GAD): MYL1

Export disorders for MYL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MYL1 gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with MYL1)

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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. (PubMed id 2304459)^{1, 3} Hailstones D.L. and Gunning P.W. (1990)
Identification of the functional promoter regions in the human gene encoding the myosin alkali light chains MLC1 and MLC3 of fast skeletal muscle. (PubMed id 2777779)^{1, 2} Seidel U. and Arnold H.H. (1989)
Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter. (PubMed id 3422212)^{1, 3} Cohen-Haguenauer O....Frezal J. (1988)
Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms. (PubMed id 2458299)^{1, 2} Seidel U.... Arnold H.H. (1988)
The complete nucleotide sequences of cDNA clones coding for human myosin light chains 1 and 3. (PubMed id 3601661)^{1, 2} Seidel U.... Arnold H.H. (1987)
The MLK-related kinase (MRK) is a novel RhoC effector that mediates lysophosphatidic acid (LPA)-stimulated tumor cell invasion. (PubMed id 23319595)¹ Korkina O....Ruggieri R. (2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4632	HGNC: 7582	AceView: MYL1	Ensembl:ENSG00000168530	euGenes: HUgn4632
ECgene: MYL1	H-InvDB: MYL1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MYL1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MYL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MYL1 gene:
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GeneCards and IP:
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MYL1 Gene

Myosin, Light Chain 1, Alkali; Skeletal, Fast

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MYL1 Gene

Myosin, Light Chain 1, Alkali; Skeletal, Fast

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