Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MYL1 Gene

protein-coding GIFtS: 62
GCID: GC02M211118

myosin, light chain 1, alkali; skeletal, fast

(Previous names: myosin, light polypeptide 1, alkali; skeletal, fast )

Explore 4 diseases affiliated with
MYL1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Myosin, Light Chain 1, Alkali; Skeletal, Fast¹ ²		MLC1F²
Myosin, Light Polypeptide 1, Alkali; Skeletal, Fast¹ ²		MLC3F²
Myosin Light Chain A1/A2² ³		A1 Catalytic²
Myosin Light Chain Alkali 1/2² ³		A2 Catalytic²
MLC1/MLC3² ³		Myosin Light Chain 1/3, Skeletal Muscle Isoform²
MLC1F/MLC3F² ³

External Ids:	HGNC: 7582¹	Entrez Gene: 4632²	Ensembl: ENSG00000168530⁷	OMIM: 160780⁵	UniProtKB: P05976³

Export aliases for MYL1 gene to outside databases

Previous GC identifers: GC02M209430 GC02M209879 GC02M211357 GC02M210980 GC02M210863 GC02M203000

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYL1:

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali

light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain

expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. (provided by RefSeq,

Jul 2008)

UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976

Function: Regulatory light chain of myosin. Does not bind calcium

summary for MYL1:

Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding

and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),

almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain

that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts

with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory

myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.

Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is

involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a

contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by

intracellular Ca2+ concentrations.

Gene Wiki entry for MYL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MYL1 gene promoter:
ER-alpha STAT2 STAT1beta c-Myb Tal-1beta STAT1alpha E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MYL1 promoter sequence

Search SABiosciences Chromatin IP Primers for MYL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33-q34 Ensembl cytogenetic band: 2q34 HGNC cytogenetic band: 2q33-q34

MYL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M211118: view genomic region (about GC identifiers)

Start:	211,154,868 bp from pter	End:	211,179,914 bp from pter
Size:	25,047 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976 (See protein sequence)

Recommended Name: Myosin light chain 1/3, skeletal muscle isoform

Size: 194 amino acids; 21145 Da

Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains

Secondary accessions: B2R4N6 B2R4T6 P06741 Q6IBD5

Alternative splicing: 2 isoforms: P05976-1 P05976-2, P06741-1 (Initiator Met-1 is removed. Contains a N-acetylalanine at position 2 (By similarity))

Explore the universe of human proteins at neXtProt for MYL1: NX_P05976

Post-translational modifications:

Isoform MLC3 is acetylated at position 2 (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P05976

MYL1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_524144.1 NP_524146.1

ENSEMBL proteins:

ENSP00000343321 ENSP00000307280

Reactome Protein details: P05976
Human Recombinant Protein Products for MYL1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: MYL1 OriGene Protein Over-expression Lysate: MYL1 OriGene Custom Protein Services for MYL1
	GenScript Custom Purified and Recombinant Proteins Services for MYL1
	Novus Biologicals MYL1 Proteins Novus Biologicals MYL1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for MYL1
	Uscn Proteins for MYL1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0005859	muscle myosin complex	NAS	3904738
GO:0030016	myofibril	IDA	8145163
GO:0030017	sarcomere	NAS	3904738
GO:0043292	contractile fiber	--	--

MYL1 for ontologies About GeneDecksing

MYL1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for MYL1
	GenScript Custom Superior Antibodies Services for MYL1
	Novus Biologicals MYL1 Antibodies
	Abcam antibodies for MYL1
	Uscn Antibodies for MYL1
	ThermoFisher Antibodies for MYL1

Assay Products for MYL1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MYL1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MYL1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MYL1 for domains About GeneDecksing

2 InterPro domains/families:

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

Graphical View of Domain Structure for InterPro Entry P05976

ProtoNet protein and cluster: P05976

UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976

Similarity: Contains 3 EF-hand domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MYL1_HUMAN, P05976

Function: Regulatory light chain of myosin. Does not bind calcium

Genatlas biochemistry entry for MYL1:

myosin,light polypeptide 1,alkali;skeletal,fast,same as MLC1-F & MLC3-F

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0008307	structural constituent of muscle	NAS	3904738

MYL1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for MYL1:

Increased G1 DNA content

9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Myl1):

behavior/neurological	cellular	embryogenesis	growth/size	mortality/aging
muscle	nervous system	normal	skeleton

MYL1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Myl1^tm1Nros for MYL1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MYL1

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MYL1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYL1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MYL1
		SwitchGear 3'UTR luciferase reporter plasmid: MYL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYL1 (see all 7) OriGene shRNA RFP: MYL1 OriGene siRNA: MYL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYL1
		Sirion Biotech Custom design and validation of potent shRNA sequences against MYL1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MYL1
			Sirion Biotech Customized adenovirus for overexpression of MYL1 Sirion Biotech Customized adenovirus for potent knockdown of MYL1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYL1 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYL1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MYL1 (NM_079422)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYL1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MYL1
		Search LifeMap BioReagents cell lines for MYL1
		Sirion Biotech Customized stable knockdown cell line services for MYL1 Sirion Biotech Customized inducible knockdown cell line services for MYL1 Sirion Biotech Customized stable overexpressing cell line services for MYL1 Sirion Biotech Customized inducible overexpressing cell line services for MYL1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_Integrin-mediated cell adhesion and migration

	Cell adhesion_Integrin-mediated cell adhesion and migration	1.00			Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases	0.49
	Cell adhesion Integrin-mediated cell adhesion and migration	1.00			Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases	0.49

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

Immune response _CCR3 signaling in eosinophils

	Immune response _CCR3 signaling in eosinophils	1.00			Inhibitory action of Lipoxins on neutrophil migration	0.51
	Immune response CCR3 signaling in eosinophils	1.00

PAK Pathway

	PAK Pathway	1.00			Epithelial Adherens Junctions	0.36
	Antioxidant Action of Vitamin-C	0.56

Striated Muscle Contraction

	Striated Muscle Contraction	1.00			Muscle contraction	0.65
	Striated Muscle Contraction	0.87

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 EMD Millipore Pathways for MYL1 (see all 7)

	Cell adhesion Integrin-mediated cell adhesion and migration
	Cell adhesion Tight junctions
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
	Immune response CCR3 signaling in eosinophils

5/16 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYL1 (see all 16)

	Activation of PKA through GPCR
	RhoA Pathway
	PKA Signaling
	Guidance Cues and Growth Cone Motility
	Antioxidant Action of Vitamin-C

8 GeneGo (Thomson Reuters) Pathways for MYL1 (see first 5)

	Signal transduction Activation of PKC via G-Protein coupled receptor
	Cell adhesion Integrin-mediated cell adhesion and migration
	Inhibitory action of Lipoxins on neutrophil migration
	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
	Immune response CCR3 signaling in eosinophils
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Cell adhesion Tight junctions
	Development MAG-dependent inhibition of neurite outgrowth

4 BioSystems Pathways for MYL1

	G13 Signaling Pathway
	Endothelin
	Regulation of Actin Cytoskeleton
	Striated Muscle Contraction

2 Reactome Pathways for MYL1

	Muscle contraction
	Striated Muscle Contraction

MYL1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MYL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/50 Interacting proteins for MYL1 (P05976³ ENSP00000307280⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 50)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EPB41	P11171³, ENSP00000290100⁴	I2D: score=1 STRING: ENSP00000290100
ACTA1	P68133³, ENSP00000355645⁴	I2D: score=1 STRING: ENSP00000355645
ACTA2	P62736³, ENSP00000224784⁴	I2D: score=1 STRING: ENSP00000224784
IL7R	P16871³	I2D: score=1
SLC2A4	P14672³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006936	muscle contraction	IDA	8145163
GO:0007517	muscle organ development	NAS	--
GO:0030049	muscle filament sliding	TAS	--
GO:0060048	cardiac muscle contraction	IEA	--

MYL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for MYL1 available from Tocris Bioscience About this table

Compound	Action	CAS #
(R)-(+)-Blebbistatin	Selective inhibitor of myosin II. Inactive enantiomer of (�)-blebbistatin (Cat. No. 1760)	--
(S)-(-)-Blebbistatin	Selective inhibitor of myosin II. Active enantiomer of (�)-blebbistatin (Cat. No. 1760)	[856925-71-8]
(�)-Blebbistatin	Selective inhibitor of myosin II	[674289-55-5]

1 HMDB Compound for MYL1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about MYL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MYL1 gene (2 alternative transcripts):

NM_079420.2 NM_079422.2

Unigene Cluster for MYL1:

Myosin, light chain 1, alkali; skeletal, fast

Hs.187338 [show with all ESTs]

Unigene Representative Sequence: BF790783

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000341685(uc002veb.3) ENST00000352451(uc002vec.3) ENST00000496436

ENST00000484290

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MYL1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYL1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MYL1
		SwitchGear 3'UTR luciferase reporter plasmid: MYL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYL1 (see all 7) OriGene shRNA RFP: MYL1 OriGene siRNA: MYL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYL1
		Sirion Biotech Custom design and validation of potent shRNA sequences against MYL1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYL1 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYL1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MYL1 (NM_079422)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYL1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MYL1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYL1

Additional cDNA sequence:

AK311892.1 AK311942.1 BC005318.1 CR456869.1 M20643.1 X05451.1

11 DOTS entries:

DT.451890 DT.100646912 DT.95136953 DT.120988964 DT.92458835 DT.100646906 DT.87046784 DT.100028901

DT.120988967 DT.120988980 DT.92012066

24/414 AceView cDNA sequences (see all 414):

F35530 F35245 AA176940 N69926 F29169 BF475776 W84453 F30560

BU581571 AA176747 F29961 F27414 F19305 AA332405 BU735983 BM678556

BM667558 AI800009 BF589612 F28438 W67279 F26328 F29650 F32732

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for MYL1 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b
SP1:
SP2:							-		-		-
SP3:					-		-		-		-		-		-		-
SP4:									-

ECgene alternative splicing isoforms for MYL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MYL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATCAACAAA

About this image

MYL1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Myocardium

Primitive Heart Tube Cells

Myocardium

Gut Tube

Foregut

Foregut Endoderm Cells

Endoderm

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Bone

Zeugopod Long Bone

Bone

Intermediate Mesoderm

Limb

Autopod

Limb

Zeugopod

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

See MYL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MYL1

SOURCE GeneReport for Unigene cluster: Hs.187338

SABiosciences Custom PCR Arrays for MYL1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MYL1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYL1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MYL1 gene from 8/30 species (see all 30) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MYL1¹	myosin, light chain 1, alkali; skeletal, fast	78.89(n) 80.67(a)		396470 NM_001044632.1 NP_001038097.1
lizard (Anolis carolinensis)	Reptilia	MYL1⁶	--	86(a)	1 ↔ 1	1(113465953-113497825)
African clawed frog (Xenopus laevis)	Amphibia	myl1-prov²	myosin light chain, alkali, fast skeletal muscle	79.94(n)		L38596.1
zebrafish (Danio rerio)	Actinopterygii	myl1¹	myosin, light chain 1, alkali; skeletal, fast	66.67(n) 64.74(a)		336165 NM_200000.1 NP_956294.1
fruit fly (Drosophila melanogaster)	Insecta	Mlc-c³	myosin ATPase	53(a)		5A8 --
worm (Caenorhabditis elegans)	Secernentea	T12D8.6³ mlc-3¹	EF hand³ Protein MLC-3¹	48(a)³ 53.66(n)¹ 45.39(a)¹		III(13694513-13695376)³ 175768¹ NM_171128.6¹ NP_741145.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	MLC1¹	Mlc1p	50.49(n) 38.97(a)		852772 NP_011409.1
rice (Oryza sativa)	Liliopsida	--	OsCML9 - Calmodulin-related calcium sensor protein...	27(a)	possible ortholog	5(24067532-24068539)

ENSEMBL Gene Tree for MYL1 (if available)
TreeFam Gene Tree for MYL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MYL1 gene

MYL4² MYL6B² MYL6² MYL3²

18 SIMAP similar genes for MYL1 using alignment to 3 protein entries: MYL1_HUMAN (see all proteins):

MYL6 MYL3 MYL4 MYL6B CALML3 CALM2

CALM1 CALM3 CETN2 CABP1 CETN1 TNNC2

CALML5 TNNC1 EFCAB2 CABP2 CALML6 CETN3

MYL1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183771857^1,2		--	211154446(+)	`CCATCA/CCAGAG`	2	--	ds500¹		0	--	--	--	--
rs190554036^1,2		--	211154559(+)	`ATTGTC/TACTAG`	2	--	ds500¹		0	--	--	--	--
rs13020232^1,2	C,F,H	--	211154625(+)	`GTTTTC/TGCTTT`	2	--	ds500¹		13		NS EA NA WA	1056
rs182227787^1,2		--	211154753(+)	`GTAGAC/TTTCAG`	2	--	ds500¹		0	--	--	--	--
rs186770286^1,2		--	211154989(+)	`TTCTCA/TTCTAG`	2	--	ut3¹		0	--	--	--	--
rs191693602^1,2		--	211155050(+)	`GAAGAC/TGTATA`	2	--	ut3¹		0	--	--	--	--
rs181484899^1,2		--	211155085(+)	`TGAACC/TGTCCA`	2	--	ut3¹		0	--	--	--	--
rs75879736^1,2		--	211155308(+)	`CACTTA/GCAAGA`	2	--	int¹		1		WA	118
rs76671123^1,2	C,F	--	211155321(+)	`AGCCAA/GTTCCT`	2	--	int¹		1		WA	118
rs115480346^1,2	F	--	211155648(+)	`ATCTCG/ATAATT`	2	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for MYL1 (211154868 - 211179914 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MYL1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYL1

DNA2.0 Custom Variant and Variant Library Synthesis for MYL1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MYL1 for disorders           About GeneDecksing

OMIM gene information: 160780    OMIM disorders: --

4 diseases for MYL1:    About MalaCards

influenza rhabdomyosarcoma laryngitis ischemia

Export disorders for MYL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MYL1 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with MYL1)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. (PubMed id 2304459)^{1, 3} Hailstones D.L. and Gunning P.W. (1990)
Identification of the functional promoter regions in the human gene encoding the myosin alkali light chains MLC1 and MLC3 of fast skeletal muscle. (PubMed id 2777779)^{1, 2} Seidel U. and Arnold H.H. (1989)
Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms. (PubMed id 2458299)^{1, 2} Seidel U.... Arnold H.H. (1988)
Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter. (PubMed id 3422212)^{1, 3} Cohen-Haguenauer O....Frezal J. (1988)
The complete nucleotide sequences of cDNA clones coding for human myosin light chains 1 and 3. (PubMed id 3601661)^{1, 2} Seidel U.... Arnold H.H. (1987)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Mutations of ventricular essential myosin light chain disturb myosin binding and sarcomeric sorting. (PubMed id 22131351)¹ Lossie J....Morano I. (2012)
Inhibition of MLC phosphorylation restricts replicati on of influenza virus--a mechanism of action for anti-influenza agents. (PubMed id 21731751)¹ Haidari M....Chen Z. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4632	HGNC: 7582	AceView: MYL1	Ensembl:ENSG00000168530	euGenes: HUgn4632
ECgene: MYL1	H-InvDB: MYL1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MYL1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MYL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MYL1 gene:
Search GeneIP for patents involving MYL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for MYL1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYL1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYL1
	OriGene Protein Over-expression Lysate for MYL1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for MYL1		OriGene 3'-UTR Clone for MYL1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYL1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYL1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for MYL1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MYL1		OriGene Custom Protein Services for MYL1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MYL1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYL1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYL1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYL1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYL1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYL1

	GenScript Custom Purified and Recombinant Proteins Services for MYL1		GenScript cDNA clones with any tag delivered in your preferred vector for MYL1
	GenScript Custom Assay Services for MYL1		GenScript Custom Superior Antibodies Services for MYL1
	GenScript Custom overexpressing Cell Line Services for MYL1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in MYL1 promoter
	Search Chromatin IP Primers for MYL1
	RT² qPCR Primer Assay in human, mouse, rat MYL1
	Search GNC Networks for MYL1
	SABiosciences PCR Arrays including human, mouse, rat MYL1

Tocris compounds for MYL1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	MYL1 antibodies
	MYL1 proteins
	MYL1 lysates

	Antibodies for MYL1
	See all of Abcam's Antibodies, Kits and Proteins for MYL1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for MYL1

MYL1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for MYL1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL1

	SwitchGear 3'UTR luciferase reporter plasmids for MYL1
	SwitchGear Promoter luciferase reporter plasmids for MYL1

ThermoFisher Antibodies for MYL1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYL1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MYL1

Sirion Biotech Customized:

	stable knockdown cell line services for MYL1
	inducible knockdown cell line services for MYL1
	design and validation of potent shRNA sequences against MYL1
	adenovirus for potent knockdown of MYL1
	adenovirus for overexpression of MYL1
	stable overexpressing cell line services for MYL1
	inducible overexpressing cell line services for MYL1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MYL1 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

MYL1 Gene

myosin, light chain 1, alkali; skeletal, fast

Aliases
for MYL1 gene

Summaries
for MYL1 gene

Genomic Views
for MYL1 gene

Proteins
for MYL1 gene

Protein Domains /
Families
for MYL1 gene

Function
for MYL1 gene

Pathways & Interactions
for MYL1 gene

Drugs & Compounds
for MYL1 gene

Transcripts
for MYL1 gene

Expression
for MYL1 gene

Orthologs
for MYL1 gene

Paralogs
for MYL1 gene

Genomic Variants
for MYL1 gene

Disorders / Diseases
for MYL1 gene

Publications
for MYL1 gene

External Searches for MYL1 gene

Genome Databases showing MYL1 gene

Other Databases showing MYL1 gene

Specialized Databases showing MYL1 gene

Intellectual Property
for MYL1 gene

Products
for MYL1 gene

View Random Gene

Advanced Search

Export list of displayed genes

MYL1 Gene

myosin, light chain 1, alkali; skeletal, fast

Aliasesfor MYL1 gene

Summariesfor MYL1 gene

Genomic Viewsfor MYL1 gene

Proteinsfor MYL1 gene

Protein Domains /Familiesfor MYL1 gene

Functionfor MYL1 gene

Pathways & Interactionsfor MYL1 gene

Drugs & Compoundsfor MYL1 gene

Transcriptsfor MYL1 gene

Expression for MYL1 gene

Orthologsfor MYL1 gene

Paralogsfor MYL1 gene

Genomic Variantsfor MYL1 gene

Disorders / Diseasesfor MYL1 gene

Publicationsfor MYL1 gene

External Searches for MYL1 gene

Genome Databases showing MYL1 gene

Other Databases showing MYL1 gene

Specialized Databases showing MYL1 gene

Intellectual Propertyfor MYL1 gene

Productsfor MYL1 gene

View Random Gene

Aliases
for MYL1 gene

Summaries
for MYL1 gene

Genomic Views
for MYL1 gene

Proteins
for MYL1 gene

Protein Domains /
Families
for MYL1 gene

Function
for MYL1 gene

Pathways & Interactions
for MYL1 gene

Drugs & Compounds
for MYL1 gene

Transcripts
for MYL1 gene

Expression
for MYL1 gene

Orthologs
for MYL1 gene

Paralogs
for MYL1 gene

Genomic Variants
for MYL1 gene

Disorders / Diseases
for MYL1 gene

Publications
for MYL1 gene

Intellectual Property
for MYL1 gene

Products
for MYL1 gene