Aliases for MYL1 Gene
Aliases for MYL1 Gene
External Ids for MYL1 Gene
- HGNC: 7582
- Entrez Gene: 4632
- Ensembl: ENSG00000168530
- OMIM: 160780
- UniProtKB: P05976
Previous GeneCards Identifiers for MYL1 Gene
- GC02M209430
- GC02M209879
- GC02M211118
- GC02M211357
- GC02M210980
- GC02M210863
- GC02M203000
Summaries for MYL1 Gene
-
Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MYL1 Gene
MYL1 (Myosin Light Chain 1) is a Protein Coding gene. Among its related pathways are Cardiac conduction and PAK Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and structural constituent of muscle. An important paralog of this gene is MYL3.
UniProtKB/Swiss-Prot for MYL1 Gene
-
Regulatory light chain of myosin. Does not bind calcium.
-
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL1 Gene
Genomics for MYL1 Gene
GeneHancer (GH) Regulatory Elements for MYL1 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH02I210315 | Promoter/Enhancer | 0.7 | EPDnew dbSUPER | 550.8 | 0.0 | -1 | 0.1 | MYL1 LANCL1-AS1 GC02M210241 | ||
GH02I210303 | Promoter/Enhancer | 0.7 | EPDnew dbSUPER | 550.4 | +11.6 | 11555 | 0.1 | MYL1 ENSG00000199203 GC02M210241 | ||
GH02I210301 | Enhancer | 0.4 | ENCODE dbSUPER | 7.4 | +12.8 | 12764 | 1 | MYL1 ENSG00000199203 GC02M210241 | ||
GH02I210177 | Enhancer | 0.5 | ENCODE | 4.9 | +137.2 | 137160 | 0.9 | SP1 USF1 MAX POU5F1 USF2 | MYL1 ENSG00000279317 ACADL | |
GH02I210322 | Enhancer | 0.5 | ENCODE dbSUPER | 4.6 | -9.3 | -9277 | 3.3 | EZH2 | LANCL1-AS1 MYL1 GC02M210241 |
Regulatory Element Products
Genomic Locations for MYL1 Gene
- chr2:210,290,144-210,315,190
- (GRCh38/hg38)
- Size:
- 25,047 bases
- Orientation:
- Minus strand
- chr2:211,154,868-211,179,914
- (GRCh37/hg19)
Genomic View for MYL1 Gene
- Cytogenetic band:
-
- 2q34 by Ensembl
- 2q34 by Entrez Gene
- 2q34 by HGNC


RefSeq DNA sequence for MYL1 Gene
Proteins for MYL1 Gene
-
Protein details for MYL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05976-MYL1_HUMAN
- Recommended name:
- Myosin light chain 1/3, skeletal muscle isoform
- Protein Accession:
- P05976
- B2R4N6
- B2R4T6
- P06741
- Q6IBD5
Protein attributes for MYL1 Gene
- Size:
- 194 amino acids
- Molecular mass:
- 21145 Da
- Quaternary structure:
-
- Myosin is a hexamer of 2 heavy chains and 4 light chains.
Alternative splice isoforms for MYL1 Gene
- UniProtKB/Swiss-Prot:
Protein Expression for MYL1 Gene
Post-translational modifications for MYL1 Gene
- Isoform MLC3 is acetylated at position 2.
Other Protein References for MYL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for MYL1
-
Abcam antibodies for MYL1
-
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- GeneTex MYL1 antibody for MYL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for MYL1
Protein Products
-
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-
Cloud-Clone Corp. Proteins for MYL1
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-
Abcam proteins for MYL1
Assay Products
-
Cloud-Clone Corp. Assay Kits for MYL1
- antibodies-online: Search results for 13 available MYL1 Elisa Kits ranked by validation data
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Quality Products:
No data available for DME Specific Peptides for MYL1 Gene
Domains & Families for MYL1 Gene
Gene Families for MYL1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for MYL1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MYL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for MYL1 Gene
Function for MYL1 Gene
Molecular function for MYL1 Gene
- GENATLAS Biochemistry:
- myosin,light polypeptide 1,alkali;skeletal,fast,same as MLC1-F & MLC3-F
- UniProtKB/Swiss-Prot Function:
- Regulatory light chain of myosin. Does not bind calcium.
Phenotypes From GWAS Catalog for MYL1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005509 | calcium ion binding | IEA | -- |
GO:0008307 | structural constituent of muscle | NAS | 3904738 |
Phenotypes for MYL1 Gene
- MGI mutant phenotypes for MYL1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for MYL1:
Animal Model Products
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-
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CRISPR Products
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OriGene CRISPR knockouts for MYL1
- genomics-online: gRNA clones - Search results for 137 available MYL1 gene related products
- Overview of 137 available MYL1 gene related products
- Applied Biological Materials CRISPR for MYL1
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Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
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Inhibitory RNA Products
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Clone Products
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Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MYL1 Gene
Localization for MYL1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
GO:0005859 | muscle myosin complex | NAS | 3904738 |
GO:0016459 | myosin complex | IEA | -- |
GO:0030016 | myofibril | IDA | 8145163 |
GO:0030017 | sarcomere | NAS | 3904738 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MYL1 Gene
Pathways & Interactions for MYL1 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
2 | Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases | ||
3 | PAK Pathway |
.56
|
|
4 | Actin Nucleation by ARP-WASP Complex |
.35
|
|
5 | RhoGDI Pathway |
.33
|
Pathways by source for MYL1 Gene
5 BioSystems pathways for MYL1 Gene
2 Reactome pathways for MYL1 Gene
8 GeneGo (Thomson Reuters) pathways for MYL1 Gene
16 Qiagen pathways for MYL1 Gene
Interacting Proteins for MYL1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006936 | muscle contraction | IDA | 8145163 |
GO:0030049 | muscle filament sliding | NAS,TAS | -- |
GO:0060048 | cardiac muscle contraction | IEA | -- |
No data available for SIGNOR curated interactions for MYL1 Gene
Drugs & Compounds for MYL1 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
calcium | Approved | Nutra | 0 | |||
(R)-(+)-Blebbistatin | Pharma | non-muscle myosin II ATPases inhibitor, cell-permeable, Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) | 0 | |||
BTS | Pharma | Selective inhibitor of skeletal muscle myosin II ATPase activity | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
(+-)-Blebbistatin |
|
674289-55-5 |
|
|
||
(S)-(-)-Blebbistatin |
|
856925-71-8 |
|
|
(4) Tocris Compounds for MYL1 Gene
Compound | Action | Cas Number |
---|---|---|
(+-)-Blebbistatin | Selective inhibitor of myosin II ATPase activity | 674289-55-5 |
(R)-(+)-Blebbistatin | Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) | 1177356-70-5 |
(S)-(-)-Blebbistatin | Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760) | 856925-71-8 |
BTS | Selective inhibitor of skeletal muscle myosin II ATPase activity | 1576-37-0 |
Transcripts for MYL1 Gene
mRNA/cDNA for MYL1 Gene
- (2) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (414) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MYL1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MYL1
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MYL1
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miRNA Products
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Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for 137 available MYL1 gene related products
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ViGene Biosciences ready-to-package AAV shRNAs for MYL1 gene
Clone Products
- Sino Biological Human cDNA Clone for MYL1
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- Applied Biological Materials Clones for MYL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | ||||||||||||||||
SP4: | - |
Expression for MYL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Autopod
- Zeugopod
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
- Cardiomyocytes Atrial Septum
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hyoid Arch Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
- Bone (Muscoskeletal System)
-
Kidney (Urinary System)
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Gut Tube (Gastrointestinal Tract)
- Adipose (Muscoskeletal System)
-
Prostate (Endocrine System)
-
Thyroid (Endocrine System)
-
Lung (Respiratory System)
-
Esophagus (Gastrointestinal Tract)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for MYL1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYL1 Gene
NURSA nuclear receptor signaling pathways regulating expression of MYL1 Gene:
MYL1SOURCE GeneReport for Unigene cluster for MYL1 Gene:
Hs.187338Evidence on tissue expression from TISSUES for MYL1 Gene
- Muscle(5)
- Liver(4.2)
- Heart(3.2)
- Nervous system(2)
Primer Products
-
OriGene qPCR primer pairs for MYL1
-
OriGene qPCR primer pairs and template standards for MYL1
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No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYL1 Gene
Orthologs for MYL1 Gene
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | MYL1 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | MYL1 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | MYL1 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | MYL1 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | MYL1 34 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Myl1 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Myl1 33 |
|
||
chicken (Gallus gallus) |
Aves | MYL1 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | MYL1 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | myl1 33 |
|
||
MGC75774 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | myl1-prov 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | myl1 33 34 |
|
||
mylz3 34 |
|
OneToMany | |||
fruit fly (Drosophila melanogaster) |
Insecta | Mlc-c 35 34 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | T12D8.6 35 |
|
|
|
mlc-6 34 |
|
ManyToMany | |||
mlc-5 34 |
|
ManyToMany | |||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFL030C 33 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F10439g 33 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MLC1 33 34 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.211 34 |
|
ManyToMany | |
CSA.4806 34 |
|
ManyToMany | |||
CSA.6288 34 |
|
ManyToMany | |||
CSA.6678 34 |
|
ManyToMany | |||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | cdc4 33 |
|
||
bread mold (Neurospora crassa) |
Ascomycetes | NCU06617 33 |
|
- Species where no ortholog for MYL1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MYL1 Gene
(18) SIMAP similar genes for MYL1 Gene using alignment to 3 proteins:
Variants for MYL1 Gene
SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000115659 | -- | 210,303,712(-) | A/G | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000128713 | -- | 210,309,764(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
rs1000178468 | -- | 210,291,383(-) | C/G | intron_variant | |
rs1000261985 | -- | 210,310,056(-) | C/A | genic_upstream_transcript_variant, intron_variant | |
rs1000314675 | -- | 210,309,727(-) | T/A | genic_upstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4163n100 | CNV | gain | 25217958 |
nsv1012567 | CNV | gain | 25217958 |
nsv834520 | CNV | loss | 17160897 |
Additional Variant Information for MYL1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MYL1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYL1 Gene
Disorders for MYL1 Gene
Additional Disease Information for MYL1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for MYL1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYL1 Gene
Publications for MYL1 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. (PMID: 2304459) Hailstones DL … Gunning PW (Molecular and cellular biology 1990) 2 3 58
- Identification of the functional promoter regions in the human gene encoding the myosin alkali light chains MLC1 and MLC3 of fast skeletal muscle. (PMID: 2777779) Seidel U … Arnold HH (The Journal of biological chemistry 1989) 3 4 58
- Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter. (PMID: 3422212) Cohen-Haguenauer O … Frézal J (Human genetics 1988) 2 3 58
- Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms. (PMID: 2458299) Seidel U … Arnold HH (Gene 1988) 3 4 58
Products for MYL1 Gene
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- antibodies-online: Search results for available MYL1 related products ranked by validation data
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Sources for MYL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
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