Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneAnalytics
- GeneLoc
- GenesLikeMe
- VarElect
- PathCards
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Suite
- Affiliated Databases
  
  Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

MYL1 Gene

protein-coding GIFtS: 63
GCID: GC02M211118

Myosin, Light Chain 1, Alkali; Skeletal, Fast

(Previous names: myosin, light polypeptide 1, alkali; skeletal, fast)

Try our

MalaCards

disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Myosin, Light Chain 1, Alkali; Skeletal, Fast¹ ²		MLC1F²
Myosin, Light Polypeptide 1, Alkali; Skeletal, Fast¹ ²		MLC3F²
Myosin Light Chain A1/A2² ³		A1 Catalytic²
Myosin Light Chain Alkali 1/2² ³		A2 Catalytic²
MLC1/MLC3² ³		Myosin Light Chain 1/3, Skeletal Muscle Isoform²
MLC1F/MLC3F² ³

External Ids:	HGNC: 7582¹	Entrez Gene: 4632²	Ensembl: ENSG00000168530⁷	OMIM: 160780⁵	UniProtKB: P05976³

Export aliases for MYL1 gene to outside databases

Previous GC identifers: GC02M209430 GC02M209879 GC02M211357 GC02M210980 GC02M210863 GC02M203000

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYL1 Gene:

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable

alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light

chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. (provided by

RefSeq, Jul 2008)

GeneCards Summary for MYL1 Gene:

MYL1 (myosin, light chain 1, alkali; skeletal, fast) is a protein-coding gene. GO annotations related to this gene include structural constituent of muscle and calcium ion binding. An important paralog of this gene is MYL4.

UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976

Function: Regulatory light chain of myosin. Does not bind calcium

summary for MYL1 Gene:

Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding

and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),

almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain

that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts

with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory

myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.

Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is

involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a

contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by

intracellular Ca2+ concentrations.

Gene Wiki entry for MYL1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000002.11 NC_018913.2 NT_005403.18

Regulatory elements:

Regulatory transcription factor binding sites in the MYL1 gene promoter:
ER-alpha STAT2 STAT1beta c-Myb Tal-1beta STAT1alpha E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MYL1 promoter sequence

Search Chromatin IP Primers for MYL1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33-q34 Ensembl cytogenetic band: 2q34 HGNC cytogenetic band: 2q33-q34

MYL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M211118: view genomic region (about GC identifiers)

Start:	211,154,868 bp from pter	End:	211,179,914 bp from pter
Size:	25,047 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976 (See protein sequence)

Recommended Name: Myosin light chain 1/3, skeletal muscle isoform

Size: 194 amino acids; 21145 Da

Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains

Secondary accessions: B2R4N6 B2R4T6 P06741 Q6IBD5

Alternative splicing: 2 isoforms: P05976-1 P05976-2, P06741-1 (Initiator Met-1 is removed. Contains a N-acetylalanine at position 2 (By similarity))

Explore the universe of human proteins at neXtProt for MYL1: NX_P05976

Explore proteomics data for MYL1 at MOPED

Post-translational modifications:

Isoform MLC3 is acetylated at position 2 (By similarity)¹

Ubiquitination² at Lys141

Modification sites at PhosphoSitePlus

See MYL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_524144.1 NP_524146.1

ENSEMBL proteins:

ENSP00000343321 ENSP00000307280

Reactome Protein details: P05976

MYL1 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for MYL1 OriGene Protein Over-expression Lysate for MYL1 OriGene MassSpec for MYL1 OriGene Custom Protein Services for MYL1
	GenScript Custom Purified and Recombinant Proteins Services for MYL1
	Novus Biologicals MYL1 Proteins Novus Biologicals MYL1 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for MYL1
	Cloud-Clone Corp. Proteins for MYL1
	Search eBioscience for Proteins for MYL1
	Search GeneTex for Proteins for MYL1
	antibodies-online proteins for MYL1 (9 products)
	Search antibodies-online for peptides for MYL1

MYL1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for MYL1
	Novus Biologicals MYL1 Antibodies
	Abcam antibodies for MYL1 (Q9Y623, Q14324, P11055, P06741, P05976, P60660, P12882)
	Cloud-Clone Corp. Antibodies for MYL1
	ThermoFisher Antibody for MYL1
	antibodies-online antibodies for MYL1 (20 products)

MYL1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for MYL1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MYL1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for MYL1 Cloud-Clone Corp. CLIAs for MYL1
	Search eBioscience for ELISAs for MYL1
	antibodies-online kits for MYL1 (10 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

EFHAND: EF-hand domain containing

MYL: Myosins / Light chain

2 InterPro protein domains:

IPR011992 EF-hand-dom_pair

IPR002048 EF_hand_dom

Graphical View of Domain Structure for InterPro Entry P05976

ProtoNet protein and cluster: P05976

UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976

Similarity: Contains 3 EF-hand domains

Find genes that share domains with MYL1 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MYL1_HUMAN, P05976

Function: Regulatory light chain of myosin. Does not bind calcium

Genatlas biochemistry entry for MYL1:

myosin,light polypeptide 1,alkali;skeletal,fast,same as MLC1-F & MLC3-F

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0008307	structural constituent of muscle	NAS	3904738

Find genes that share ontologies with MYL1 About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for MYL1:

Increased G1 DNA content

9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Myl1):

behavior/neurological	cellular	embryogenesis	growth/size/body	mortality/aging
muscle	nervous system	normal	skeleton

Find genes that share phenotypes with MYL1 About GenesLikeMe

Animal Models:
MGI mouse knock-out Myl1^tm1Nros for MYL1

genOway: Develop your customized and physiologically relevant rodent model for MYL1

miRNA Products:		Block miRNA regulation of human, mouse, rat MYL1 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate MYL1
		SwitchGear 3'UTR luciferase reporter plasmid: MYL1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MYL1
		Predesigned siRNA for gene silencing in human, mouse, rat MYL1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MYL1

Clone Products:		OriGene clones in human, mouse for MYL1 (see all 14) OriGene ORF clones in mouse, rat for MYL1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MYL1 (NM_079422)
		Sino Biological Human cDNA Clone for MYL1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYL1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MYL1
		Browse ESI BIO Cell Lines and PureStem Progenitors for MYL1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	4
cytosol	4
extracellular	1
mitochondrion	1
nucleus	1

About this image

Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0005859	muscle myosin complex	NAS	3904738
GO:0030016	myofibril	IDA	8145163
GO:0030017	sarcomere	NAS	3904738
GO:0043292	contractile fiber	--	--

Find genes that share ontologies with MYL1 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for MYL1 About (see all 17)

See pathways by source

Powered
by

SuperPath

Contained pathways About

Striated Muscle Contraction

	Striated Muscle Contraction	0.82			Muscle contraction	0.61
	Striated Muscle Contraction	0.82

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	0.77			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

Cell adhesion Integrin-mediated cell adhesion and migration

	Cell adhesion Integrin-mediated cell adhesion and migration	0.49			Development MAG-dependent inhibition of neurite outgrowth	0.42
	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases	0.49			Cell adhesion Tight junctions	0.32

PAK Pathway

	PAK Pathway	0.56			Epithelial Adherens Junctions	0.36
	Antioxidant Action of Vitamin-C	0.56

Actin Nucleation by ARP-WASP Complex

Actin Nucleation by ARP-WASP Complex

0.66

RhoA Pathway

0.35

Find genes that share SuperPaths with MYL1 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYL1 (see all 16)

	Activation of PKA through GPCR
	RhoA Pathway
	PKA Signaling
	Guidance Cues and Growth Cone Motility
	Antioxidant Action of Vitamin-C

8 GeneGo (Thomson Reuters) Pathways for MYL1 (see first 5)

	Signal transduction Activation of PKC via G-Protein coupled receptor
	Cell adhesion Integrin-mediated cell adhesion and migration
	Inhibitory action of Lipoxins on neutrophil migration
	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
	Immune response CCR3 signaling in eosinophils
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Cell adhesion Tight junctions
	Development MAG-dependent inhibition of neurite outgrowth

4 BioSystems Pathways for MYL1

	G13 Signaling Pathway
	Regulation of Actin Cytoskeleton
	Striated Muscle Contraction
	Endothelin

1 Reactome Pathway for MYL1

Striated Muscle Contraction

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for MYL1
Interactions:

Search GeneGlobe Interaction Network for MYL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for MYL1 (P05976³ ENSP00000307280⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 75)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EPB41	P11171³, ENSP00000290100⁴	I2D: score=1 STRING: ENSP00000290100
ACTA1	P68133³, ENSP00000355645⁴	I2D: score=1 STRING: ENSP00000355645
ACTA2	P62736³, ENSP00000224784⁴	I2D: score=1 STRING: ENSP00000224784
IL7R	P16871³	I2D: score=1
SLC2A4	P14672³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006936	muscle contraction	IDA	8145163
GO:0007517	muscle organ development	--	--
GO:0030049	muscle filament sliding	TAS	--
GO:0060048	cardiac muscle contraction	IEA	--

Find genes that share ontologies with MYL1 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Compounds for MYL1 available from Tocris Bioscience About this table

Compound	Action	CAS #
BTS	Selective inhibitor of skeletal muscle myosin II ATPase activity	[1576-37-0]
(R)-(+)-Blebbistatin	Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)	[1177356-70-5]
(S)-(-)-Blebbistatin	Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)	[856925-71-8]
(+-)-Blebbistatin	Selective inhibitor of myosin II ATPase activity	[674289-55-5]

1 HMDB Compound for MYL1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for MYL1 gene (2 alternative transcripts):

NM_079420.2 NM_079422.2

Unigene Cluster for MYL1:

Myosin, light chain 1, alkali; skeletal, fast

Hs.187338 [show with all ESTs]

Unigene Representative Sequence: BF790783

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000341685(uc002veb.3) ENST00000352451(uc002vec.3) ENST00000496436

ENST00000484290

miRNA Products:		Block miRNA regulation of human, mouse, rat MYL1 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate MYL1
		SwitchGear 3'UTR luciferase reporter plasmid: MYL1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MYL1
		Predesigned siRNA for gene silencing in human, mouse, rat MYL1

Clone Products:		OriGene clones in human, mouse for MYL1 (see all 14) OriGene ORF clones in mouse, rat for MYL1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MYL1 (NM_079422)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYL1

Primer Products:		OriGene qPCR primer pairs and template standards for MYL1 OriGene qSTAR qPCR primer pairs in human, mouse for MYL1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat MYL1
		QuantiTect SYBR Green Assays in human, mouse, rat MYL1
		QuantiFast Probe-based Assays in human, mouse, rat MYL1

Additional mRNA sequence:

AK311892.1 AK311942.1 BC005318.1 CR456869.1 M20643.1 X05451.1

11 DOTS entries:

DT.451890 DT.100646912 DT.95136953 DT.120988964 DT.92458835 DT.100646906 DT.87046784 DT.100028901

DT.120988967 DT.120988980 DT.92012066

Selected AceView cDNA sequences (see all 414):

F28438 W84453 F19305 AA993535 BU735911 F25010 AA176940 BM667508

BM678600 CR598137 F30560 BF475776 F29303 F35530 F31356 F32732

BM720926 BM667558 BM678556 W67183 F30858 F31527 F27414 AA332405

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for MYL1 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b
SP1:
SP2:							-		-		-
SP3:					-		-		-		-		-		-		-
SP4:									-

ECgene alternative splicing isoforms for MYL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MYL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AATCAACAAA

About this image

MYL1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 13) fully expand


Heart (Cardiovascular System) fully expand to see all 2 entries
Cardiomyocytes Atrial Septum

Limb (Muscoskeletal System) fully expand to see all 3 entries
Mesenchymal Condensate Cells Zeugopod
Zeugopod

Bone (Muscoskeletal System) fully expand to see all 2 entries
Mesenchymal Condensate Cells Zeugopod
Zeugopod Long Bone

Skeletal Muscle (Muscoskeletal System) fully expand to see all 2 entries
Mononuclear Myocytes Hyoid Arch Muscles

Gut Tube (Gastrointestinal Tract)
Foregut

MYL1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

MYL1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.187338

Custom PCR Arrays for MYL1

Primer Products:		OriGene qPCR primer pairs and template standards for MYL1 OriGene qSTAR qPCR primer pairs in human, mouse for MYL1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat MYL1
		QuantiTect SYBR Green Assays in human, mouse, rat MYL1
		QuantiFast Probe-based Assays in human, mouse, rat MYL1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYL1 gene from Selected species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Myl1^{1 , 5}	myosin, light polypeptide 1^{1, 5}	88.54(n)¹ 93.75(a)¹		1 (33.71 cM)⁵ 17901¹ NM_021285.3¹ NP_067260.1¹ 66924295⁵
chicken (Gallus gallus)	Aves	MYL1¹	myosin, light chain 1, alkali; skeletal, fast	78.89(n) 80.67(a)		396470 NM_001044632.1 NP_001038097.1
lizard (Anolis carolinensis)	Reptilia	MYL1⁶	myosin, light chain 1, alkali; skeletal, fast	86(a)	1 ↔ 1	1(113465920-113497825)
African clawed frog (Xenopus laevis)	Amphibia	myl1-prov²	myosin light chain, alkali, fast skeletal muscle	79.94(n)		L38596.1
zebrafish (Danio rerio)	Actinopterygii	myl1¹	myosin, light chain 1, alkali; skeletal, fast	67.3(n) 63.52(a)		336165 NM_200000.1 NP_956294.1
fruit fly (Drosophila melanogaster)	Insecta	Mlc-c³	myosin ATPase	53(a)		5A8 --
worm (Caenorhabditis elegans)	Secernentea	T12D8.6³	EF hand	48(a)		III(13694513-13695376) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	MLC1¹	MLC1	50.25(n) 38.97(a)		852772 NP_011409.1

ENSEMBL Gene Tree for MYL1 (if available)
TreeFam Gene Tree for MYL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for MYL1 gene

MYL4² MYL6B² MYL6² MYL3²

18 SIMAP similar genes for MYL1 using alignment to 3 protein entries: MYL1_HUMAN (see all proteins):

MYL6 MYL3 MYL4 MYL6B CALML3 CALM3

CALM1 CALM2 CETN2 CABP1 CETN1 TNNC2

CALML5 TNNC1 EFCAB2 CABP2 CALML6 CETN3

Find genes that share paralogs with MYL1 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183771857^1,2		--	211154446(+)	`CCATCA/CCAGAG`	2	--	ds500¹		0	--	--	--	--
rs190554036^1,2		--	211154559(+)	`ATTGTC/TACTAG`	2	--	ds500¹		0	--	--	--	--
rs13020232^1,2	C,F,H	--	211154625(+)	`GTTTTC/TGCTTT`	2	--	ds500¹		13		NS EA NA WA	1056
rs182227787^1,2	C	--	211154753(+)	`GTAGAC/TTTCAG`	2	--	ds500¹		0	--	--	--	--
rs186770286^1,2		--	211154989(+)	`TTCTCA/TTCTAG`	2	--	ut3¹		0	--	--	--	--
rs191693602^1,2		--	211155050(+)	`GAAGAC/TGTATA`	2	--	ut3¹		0	--	--	--	--
rs181484899^1,2		--	211155085(+)	`TGAACC/TGTCCA`	2	--	ut3¹		0	--	--	--	--
rs75879736^1,2	F	--	211155308(+)	`CACTTA/GCAAGA`	2	--	int¹		1		WA	118
rs76671123^1,2	C,F	--	211155321(+)	`AGCCAA/GTTCCT`	2	--	int¹		1		WA	118
rs115480346^1,2	F	--	211155648(+)	`ATCTCG/ATAATT`	2	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for MYL1 (211154868 - 211179914 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for MYL1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv834520	CNV	Loss	17160897
nsv875767	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MYL1

DNA2.0 Custom Variant and Variant Library Synthesis for MYL1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 160780 OMIM disorders: --

Find genes that share disorders with MYL1 About GenesLikeMe

Genetic Association Database (GAD): MYL1

Export disorders for MYL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MYL1 gene, integrated from 10 sources (see all 34):
(articles sorted by number of sources associating them with MYL1)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. (PubMed id 2304459)^{1, 3} Hailstones D.L. and Gunning P.W. (Mol. Cell. Biol. 1990)
Identification of the functional promoter regions in the human gene encoding the myosin alkali light chains MLC1 and MLC3 of fast skeletal muscle. (PubMed id 2777779)^{1, 2} Seidel U. and Arnold H.H. (J. Biol. Chem. 1989)
Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter. (PubMed id 3422212)^{1, 3} Cohen-Haguenauer O....FrAczal J. (Hum. Genet. 1988)
Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms. (PubMed id 2458299)^{1, 2} Seidel U.... Arnold H.H. (Gene 1988)
The complete nucleotide sequences of cDNA clones coding for human myosin light chains 1 and 3. (PubMed id 3601661)^{1, 2} Seidel U.... Arnold H.H. (Nucleic Acids Res. 1987)
The MLK-related kinase (MRK) is a novel RhoC effector that mediates lysophosphatidic acid (LPA)-stimulated tumor cell invasion. (PubMed id 23319595)¹ Korkina O....Ruggieri R. (J. Biol. Chem. 2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (amp 2012)
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4632	HGNC: 7582	AceView: MYL1	Ensembl:ENSG00000168530	euGenes: HUgn4632
ECgene: MYL1	H-InvDB: MYL1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MYL1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MYL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MYL1 gene:
Search GeneIP for patents involving MYL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for MYL1
	OriGene qPCR primer pairs and template standards for MYL1		OriGene Protein Over-expression Lysate for MYL1
	OriGene MassSpec for MYL1		OriGene clones in human, mouse for MYL1
	OriGene qSTAR qPCR primer pairs in human, mouse for MYL1		OriGene Purified Protein for MYL1
	OriGene ORF clones in mouse, rat for MYL1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MYL1		OriGene Custom Protein Services for MYL1

	Block miRNA regulation of human, mouse, rat MYL1 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing MYL1
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYL1		Predesigned siRNA for gene silencing in human, mouse, rat MYL1
	QuantiFast Probe-based Assays in human, mouse, rat MYL1		QuantiTect SYBR Green Assays in human, mouse, rat MYL1
	Custom PCR Arrays for MYL1		Search Chromatin IP Primers for MYL1
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat MYL1		Search GeneGlobe Interaction Network for MYL1
	Regulatory tfbs in MYL1 promoter

	GenScript Custom Purified and Recombinant Proteins Services for MYL1		GenScript cDNA clones with any tag delivered in your preferred vector for MYL1
	GenScript Custom Assay Services for MYL1		GenScript Custom overexpressing Cell Line Services for MYL1
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Tocris compounds for MYL1

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	cDNA Clones for MYL1
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	MYL1 antibodies
	MYL1 proteins
	MYL1 lysates

	Antibodies for MYL1
	See all of Abcam's Antibodies, Kits and Proteins for MYL1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for MYL1

	Proteins for MYL1
	Antibodies for MYL1
	ELISAs for MYL1
	CLIAs for MYL1

Browse ESI BIO Cell Lines and PureStem Progenitors for MYL1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL1

	SwitchGear 3'UTR luciferase reporter plasmids for MYL1
	SwitchGear Promoter luciferase reporter plasmids for MYL1

ThermoFisher Antibody for MYL1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYL1

Browse compounds at ApexBio

Search Addgene for plasmids for MYL1

	Search eBioscience for proteins for MYL1
	Search eBioscience for elisas for MYL1
	eBioscience FlowRNA Probe Sets

genOway: Develop your customized and physiologically relevant rodent model for MYL1

	antibodies-online antibodies for MYL1 (20 products)
	antibodies-online kits for MYL1 (10 products)
	Search antibodies-online for peptides for MYL1
	antibodies-online proteins for MYL1 (9 products)

Search GeneTex for proteins for MYL1

GeneCards Home - Full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015 , 3 Feb 2015

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MYL1 gene at Home site.

Version: 3.12.352 5 Mar 2015
hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4

GeneCards Suite

Advanced Search

Export list of displayed genes

MYL1 Gene

Myosin, Light Chain 1, Alkali; Skeletal, Fast

Aliases
for MYL1 gene

Summaries
for MYL1 gene

Genomic Views
for MYL1 gene

Proteins
for MYL1 gene

MYL1 Human Recombinant Protein Products:

MYL1 Antibody Products:

MYL1 Assay Products:

Domains /
Families
for MYL1 gene

Function
for MYL1 gene

Localization
for MYL1 gene

Pathways & Interactions
for MYL1 gene

Drugs & Compounds
for MYL1 gene

Transcripts
for MYL1 gene

Expression
for MYL1 gene

Orthologs
for MYL1 gene

Paralogs
for MYL1 gene

Genomic Variants
for MYL1 gene

Disorders / Diseases
for MYL1 gene

Publications
for MYL1 gene

External Searches for MYL1 gene

Genome Databases showing MYL1 gene

Other Databases showing MYL1 gene

Specialized Databases showing MYL1 gene

Intellectual Property
for MYL1 gene

Products
for MYL1 gene

View Random Gene

GeneCards Suite

Advanced Search

Export list of displayed genes

MYL1 Gene

Myosin, Light Chain 1, Alkali; Skeletal, Fast

Aliasesfor MYL1 gene

Summariesfor MYL1 gene

Genomic Viewsfor MYL1 gene

Proteinsfor MYL1 gene

MYL1 Human Recombinant Protein Products:

MYL1 Antibody Products:

MYL1 Assay Products:

Domains /Familiesfor MYL1 gene

Functionfor MYL1 gene

Localizationfor MYL1 gene

Pathways & Interactionsfor MYL1 gene

Drugs & Compoundsfor MYL1 gene

Transcriptsfor MYL1 gene

Expression for MYL1 gene

Orthologsfor MYL1 gene

Paralogsfor MYL1 gene

Genomic Variantsfor MYL1 gene

Disorders / Diseasesfor MYL1 gene

Publicationsfor MYL1 gene

External Searches for MYL1 gene

Genome Databases showing MYL1 gene

Other Databases showing MYL1 gene

Specialized Databases showing MYL1 gene

Intellectual Propertyfor MYL1 gene

Productsfor MYL1 gene

View Random Gene

Aliases
for MYL1 gene

Summaries
for MYL1 gene

Genomic Views
for MYL1 gene

Proteins
for MYL1 gene

Domains /
Families
for MYL1 gene

Function
for MYL1 gene

Localization
for MYL1 gene

Pathways & Interactions
for MYL1 gene

Drugs & Compounds
for MYL1 gene

Transcripts
for MYL1 gene

Expression
for MYL1 gene

Orthologs
for MYL1 gene

Paralogs
for MYL1 gene

Genomic Variants
for MYL1 gene

Disorders / Diseases
for MYL1 gene

Publications
for MYL1 gene

Intellectual Property
for MYL1 gene

Products
for MYL1 gene