MYL1 Gene
protein-coding GIFtS : 62 GCID: GC02 M211118
myosin, light chain 1, alkali; skeletal, fast myosin, light polypeptide 1, alkali; skeletal, fast )
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Aliasesfor MYL1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Myosin, Light Chain 1, Alkali; Skeletal, Fast 1 2 MLC1F2 Myosin, Light Polypeptide 1, Alkali; Skeletal, Fast1 2 MLC3F2 Myosin Light Chain A1/A22 3 A1 Catalytic2 Myosin Light Chain Alkali 1/22 3 A2 Catalytic2 MLC1/MLC32 3 Myosin Light Chain 1/3, Skeletal Muscle Isoform2 MLC1F/MLC3F2 3
Export aliases for MYL1 gene to outside databases Previous GC identifers: GC02M209430 GC02M209879 GC02M211357 GC02M210980 GC02M210863 GC02M203000
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Summariesfor MYL1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MYL1 : Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976 Function : Regulatory light chain of myosin. Does not bind calciumsummary
for MYL1 : Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin bindingand potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domainthat binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interactswith cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatorymyosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It isinvolved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating acontractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and byintracellular Ca2+ concentrations. Gene Wiki entry for MYL1
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Viewsfor MYL1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000002.11 NC_018913.1 NT_005403.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MYL1 gene promoter:ER-alpha STAT2 STAT1beta c-Myb Tal-1beta STAT1alpha E47 Other transcription factors Search SABiosciences Chromatin IP Primers for MYL1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYL1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2q33-q34 Ensembl cytogenetic band: 2q34 HGNC cytogenetic band: 2q33-q34 MYL1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M211118: view genomic region
(about GC identifiers )
Start: 211,154,868 bp from pter End:
211,179,914 bp from pter
Size: 25,047 bases Orientation:
minus strand
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Proteinsfor MYL1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976 See
protein sequence )Recommended Name: Size : 194 amino acids; 21145 DaSubunit : Myosin is a hexamer of 2 heavy chains and 4 light chainsSecondary accessions : B2R4N6 B2R4T6 P06741 Q6IBD5Alternative splicing : 2 isoforms : P05976-1 P05976-2, P06741-1 (Initiator Met-1 is removed. Contains a N-acetylalanine at position 2 (By similarity))Explore the universe of human proteins at neXtProt for MYL1: NX_P05976 Post-translational modifications:
Isoform MLC3 is acetylated at position 2 (By similarity)1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P05976 MYL1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (2 alternative transcripts): NP_524144.1 NP_524146.1 ENSEMBL proteins: ENSP00000343321 ENSP00000307280 Reactome Protein details: P05976 Human Recombinant Protein Products: Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing MYL1 Antibody Products: Assay Products for MYL1:
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Protein
Domains /for MYL1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P05976 ProtoNet protein and cluster: P05976
UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976 Similarity : Contains 3 EF-hand domains
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Functionfor MYL1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976 Function : Regulatory light chain of myosin. Does not bind calcium
Genatlas biochemistry entry for MYL1 myosin,light polypeptide 1,alkali;skeletal,fast,same as MLC1-F & MLC3-F Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 7 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): MYL1 (NM_079422 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYL1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MYL1
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing 1 GenomeRNAi human phenotype for MYL1 :Animal Models: Myl1 tm1Nros for MYL19 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Myl1) :About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Pathways & Interactionsfor MYL1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/19 super-pathways (see all 19 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Cell adhesion_Integrin-mediated cell adhesion and migration 2 Activation of cAMP-Dependent PKA 3 Immune response _CCR3 signaling in eosinophils 4 PAK Pathway 5 Striated Muscle Contraction
Pathway sources See GeneCards unified pathways Show all pathways 5/7 (see all 7 )5/16 (see all 16 )5/8 (see all 8 )4 2 About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYL1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/50 Interacting proteins for MYL1 (P05976 3 ENSP00000307280 4 via UniProtKB, MINT, STRING , and/or I2D (see all 50 )About this table Gene Ontology (GO): 4 biological process terms (GO ID links to tree view) : About this table
About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Drugs & Compoundsfor MYL1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Compounds for MYL1 available from Tocris Bioscience About this table Compound Action
CAS
# (R)-(+)-Blebbistatin Selective inhibitor of myosin II. Inactive enantiomer of (±)-blebbistatin (Cat. No. 1760) -- (S)-(-)-Blebbistatin Selective inhibitor of myosin II. Active enantiomer of (±)-blebbistatin (Cat. No. 1760) [856925-71-8] (±)-Blebbistatin Selective inhibitor of myosin II [674289-55-5]
1 HMDB Compound for MYL1 About this table MYL1
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Transcriptsfor MYL1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MYL1 gene (2 alternative transcripts): NM_079420.2 NM_079422.2 Unigene Cluster for MYL1:
Myosin, light chain 1, alkali; skeletal, fast Hs.187338 [show with all ESTs ] Unigene Representative Sequence: BF790783 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000341685 (uc002veb.3 ) ENST00000352451 (uc002vec.3 ) ENST00000496436 ENST00000484290 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 7 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): MYL1 (NM_079422 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYL1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MYL1
Additional cDNA sequence: AK311892.1 AK311942.1 BC005318.1 CR456869.1 M20643.1 X05451.1
11 DOTS entries : DT.451890 DT.100646912
DT.95136953 DT.120988964 DT.92458835 DT.100646906 DT.87046784 DT.100028901 DT.120988967 DT.120988980 DT.92012066 24/414 AceView cDNA sequences (see all 414 ):
F35530 F35245 AA176940 N69926 F29169 BF475776 W84453 F30560 BU581571 AA176747 F29961 F27414 F19305 AA332405 BU735983 BM678556 BM667558 AI800009 BF589612 F28438 W67279 F26328 F29650 F32732 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for MYL1 About this scheme ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b SP1 : SP2 : - - - SP3 : - - - - - - - SP4 : -
ECgene alternative splicing isoforms for MYL1
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Expression for MYL1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MYL1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AATCAACAAA
About this image MYL1 expression in embryonic tissues and stem cells About this table See MYL1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MYL1 SOURCE GeneReport for Unigene cluster: Hs.187338 SABiosciences Custom PCR Arrays for MYL1 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL1
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Orthologsfor MYL1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for MYL1 gene from 8/30 species (see all 30 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves MYL11
myosin, light chain 1, alkali; skeletal, fast
78.89(n) 80.67(a)
396470 NM_001044632.1 NP_001038097.1
lizard Reptilia MYL16
--
86(a)
1 ↔ 1
1(113465953-113497825)
African clawed frog Amphibia myl1-prov2
myosin light chain, alkali, fast skeletal muscle
79.94(n)
L38596.1
zebrafish Actinopterygii myl11
myosin, light chain 1, alkali; skeletal, fast
66.67(n) 64.74(a)
336165 NM_200000.1 NP_956294.1
fruit fly Insecta Mlc-c3
myosin ATPase
53(a)
5A8 --
worm Secernentea T12D8.63 1
EF hand3 1
48(a) 3 53.66(n) 1 45.39(a) 1
III(13694513-13695376)3 175768 1 NM_171128.6 1 NP_741145.1 1
baker's yeast Saccharomycetes MLC11
Mlc1p
50.49(n) 38.97(a)
852772 NP_011409.1
rice Liliopsida --
OsCML9 - Calmodulin-related calcium sensor protein... 27(a)
possible ortholog
5(24067532-24068539)
ENSEMBL Gene Tree for MYL1 (if available)TreeFam Gene Tree for MYL1 (if available)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Paralogsfor MYL1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MYL1 gene MYL4 2 MYL6B 2 MYL6 2 MYL3 2 18 SIMAP similar genes for MYL1 using alignment to 3 protein entries: MYL1_HUMAN (see all proteins ):MYL6 MYL3 MYL4 MYL6B CALML3 CALM2 CALM1 CALM3 CETN2 CABP1 CETN1 TNNC2 CALML5 TNNC1 EFCAB2 CABP2 CALML6 CETN3 About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Variantsfor MYL1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 2 pos Sequence # AA Type More # Allele Pop Total More
summary
for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
