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Aliases for MYL1 Gene

Aliases for MYL1 Gene

  • Myosin, Light Chain 1, Alkali; Skeletal, Fast 2 3
  • Myosin, Light Polypeptide 1, Alkali; Skeletal, Fast 2 3
  • Myosin Light Chain Alkali 1/2 3 4
  • Myosin Light Chain A1/A2 3 4
  • MLC1F/MLC3F 3 4
  • MLC1/MLC3 3 4
  • Myosin Light Chain 1/3, Skeletal Muscle Isoform 3
  • A1 Catalytic 3
  • A2 Catalytic 3
  • Skeletal 6
  • MLC1F 3
  • MLC3F 3
  • FAST 6

External Ids for MYL1 Gene

Previous GeneCards Identifiers for MYL1 Gene

  • GC02M209430
  • GC02M209879
  • GC02M211118
  • GC02M211357
  • GC02M210980
  • GC02M210863
  • GC02M203000

Summaries for MYL1 Gene

Entrez Gene Summary for MYL1 Gene

  • Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYL1 Gene

MYL1 (Myosin, Light Chain 1, Alkali; Skeletal, Fast) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include calcium ion binding and structural constituent of muscle. An important paralog of this gene is MYL3.

UniProtKB/Swiss-Prot for MYL1 Gene

  • Regulatory light chain of myosin. Does not bind calcium

Tocris Summary for MYL1 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name), almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II. Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by intracellular Ca2+ concentrations.

Gene Wiki entry for MYL1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL1 Gene

Genomics for MYL1 Gene

Regulatory Elements for MYL1 Gene

Genomic Location for MYL1 Gene

210,290,144 bp from pter
210,315,190 bp from pter
25,047 bases
Minus strand

Genomic View for MYL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL1 Gene

Proteins for MYL1 Gene

  • Protein details for MYL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myosin light chain 1/3, skeletal muscle isoform
    Protein Accession:
    Secondary Accessions:
    • B2R4N6
    • B2R4T6
    • P06741
    • Q6IBD5

    Protein attributes for MYL1 Gene

    194 amino acids
    Molecular mass:
    21145 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains

    Alternative splice isoforms for MYL1 Gene


neXtProt entry for MYL1 Gene

Proteomics data for MYL1 Gene at MOPED

Post-translational modifications for MYL1 Gene

Other Protein References for MYL1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MYL1 Gene

Domains for MYL1 Gene

Gene Families for MYL1 Gene

  • EFHAND :EF-hand domain containing
  • MYL :Myosins / Light chain

Protein Domains for MYL1 Gene


Suggested Antigen Peptide Sequences for MYL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P05976
  • Contains 3 EF-hand domains.
genes like me logo Genes that share domains with MYL1: view

Function for MYL1 Gene

Molecular function for MYL1 Gene

GENATLAS Biochemistry: myosin,light polypeptide 1,alkali;skeletal,fast,same as MLC1-F & MLC3-F
UniProtKB/Swiss-Prot Function: Regulatory light chain of myosin. Does not bind calcium

Gene Ontology (GO) - Molecular Function for MYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0008307 structural constituent of muscle NAS 3904738
genes like me logo Genes that share ontologies with MYL1: view
genes like me logo Genes that share phenotypes with MYL1: view

Animal Models for MYL1 Gene

MGI Knock Outs for MYL1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for MYL1 Gene

Localization for MYL1 Gene

Subcellular locations from

Jensen Localization Image for MYL1 Gene COMPARTMENTS Subcellular localization image for MYL1 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005859 muscle myosin complex NAS 3904738
GO:0030016 myofibril IDA 8145163
GO:0030017 sarcomere NAS 3904738
GO:0043292 contractile fiber --
genes like me logo Genes that share ontologies with MYL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYL1 Gene

Pathways for MYL1 Gene

genes like me logo Genes that share pathways with MYL1: view

Gene Ontology (GO) - Biological Process for MYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction IDA 8145163
GO:0030049 muscle filament sliding TAS --
GO:0060048 cardiac muscle contraction IEA --
genes like me logo Genes that share ontologies with MYL1: view

Compounds for MYL1 Gene

(4) Tocris Compounds for MYL1 Gene

Compound Action Cas Number
(�)-Blebbistatin Selective inhibitor of myosin II ATPase activity [674289-55-5]
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (�)-blebbistatin (Cat. No. 1760) [1177356-70-5]
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (�)-blebbistatin (Cat. No. 1760) [856925-71-8]
BTS Selective inhibitor of skeletal muscle myosin II ATPase activity [1576-37-0]

(1) HMDB Compounds for MYL1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with MYL1: view

Transcripts for MYL1 Gene

mRNA/cDNA for MYL1 Gene

Unigene Clusters for MYL1 Gene

Myosin, light chain 1, alkali; skeletal, fast:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYL1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP2: - - -
SP3: - - - - - - -
SP4: -

Relevant External Links for MYL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYL1 Gene

mRNA expression in normal human tissues for MYL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYL1 Gene

This gene is overexpressed in Muscle - Skeletal (51.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYL1 Gene

SOURCE GeneReport for Unigene cluster for MYL1 Gene Hs.187338

genes like me logo Genes that share expressions with MYL1: view

No data available for mRNA Expression by UniProt/SwissProt for MYL1 Gene

Orthologs for MYL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MYL1 35
  • 97.74 (n)
  • 97.92 (a)
MYL1 36
  • 100 (a)
(Bos Taurus)
Mammalia MYL1 35
  • 92.5 (n)
  • 95.29 (a)
MYL1 36
  • 95 (a)
(Canis familiaris)
Mammalia MYL1 35
  • 93.78 (n)
  • 97.93 (a)
MYL1 36
  • 95 (a)
(Mus musculus)
Mammalia Myl1 35
  • 88.54 (n)
  • 93.75 (a)
Myl1 16
Myl1 36
  • 95 (a)
(Monodelphis domestica)
Mammalia MYL1 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia MYL1 36
  • 89 (a)
(Rattus norvegicus)
Mammalia Myl1 35
  • 87.29 (n)
  • 94.37 (a)
(Gallus gallus)
Aves MYL1 35
  • 78.89 (n)
  • 80.67 (a)
MYL1 36
  • 87 (a)
(Anolis carolinensis)
Reptilia MYL1 36
  • 86 (a)
African clawed frog
(Xenopus laevis)
Amphibia myl1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75774 35
myl1 35
  • 80.25 (n)
  • 85.99 (a)
(Danio rerio)
Actinopterygii myl1 35
  • 67.3 (n)
  • 63.52 (a)
myl1 36
  • 64 (a)
mylz3 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mlc-c 36
  • 51 (a)
Mlc-c 37
  • 53 (a)
(Caenorhabditis elegans)
Secernentea mlc-5 36
  • 47 (a)
mlc-6 36
  • 48 (a)
T12D8.6 37
  • 48 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL030C 35
  • 50.51 (n)
  • 40.15 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MLC1 35
  • 50.25 (n)
  • 38.97 (a)
MLC1 36
  • 35 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F10439g 35
  • 50.5 (n)
  • 40.3 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06617 35
  • 44.29 (n)
  • 34.27 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdc4 35
  • 49.12 (n)
  • 39.85 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.211 36
  • 60 (a)
CSA.4806 36
  • 46 (a)
CSA.6288 36
  • 46 (a)
CSA.6678 36
  • 46 (a)
Species with no ortholog for MYL1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYL1 Gene

Gene Tree for MYL1 (if available)
Gene Tree for MYL1 (if available)

Paralogs for MYL1 Gene

Paralogs for MYL1 Gene

Selected SIMAP similar genes for MYL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MYL1: view

Variants for MYL1 Gene

Sequence variations from dbSNP and Humsavar for MYL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1057219 -- 210,298,481(-) CGAGC(C/T)CTGGG synonymous-codon, reference
rs1074158 -- 210,310,319(+) GTTTT(A/G)TCATA intron-variant
rs1135254 -- 210,298,541(-) CTCCT(C/G)TTTGA synonymous-codon, reference
rs1472955 -- 210,303,914(+) CTTAG(A/G)ATTTC intron-variant, upstream-variant-2KB
rs1803984 -- 210,290,340(-) ACTCC(C/T)TGAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MYL1 Gene

Variant ID Type Subtype PubMed ID
nsv834520 CNV Loss 17160897
nsv875767 CNV Gain 21882294

Relevant External Links for MYL1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYL1 Gene

Disorders for MYL1 Gene

Relevant External Links for MYL1

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with MYL1: view

No data available for UniProtKB/Swiss-Prot for MYL1 Gene

Publications for MYL1 Gene

  1. Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. (PMID: 2304459) Hailstones D.L. … Gunning P.W. (Mol. Cell. Biol. 1990) 2 3
  2. Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms. (PMID: 2458299) Seidel U. … Arnold H.H. (Gene 1988) 3 4
  3. Identification of the functional promoter regions in the human gene encoding the myosin alkali light chains MLC1 and MLC3 of fast skeletal muscle. (PMID: 2777779) Seidel U. … Arnold H.H. (J. Biol. Chem. 1989) 3 4
  4. Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter. (PMID: 3422212) Cohen-Haguenauer O. … FrAczal J. (Hum. Genet. 1988) 2 3
  5. The complete nucleotide sequences of cDNA clones coding for human myosin light chains 1 and 3. (PMID: 3601661) Seidel U. … Arnold H.H. (Nucleic Acids Res. 1987) 3 4

Products for MYL1 Gene

Sources for MYL1 Gene

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