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Aliases for MYL1 Gene

Aliases for MYL1 Gene

  • Myosin Light Chain 1 2 3 5
  • Myosin, Light Polypeptide 1, Alkali; Skeletal, Fast 2 3
  • Myosin, Light Chain 1, Alkali; Skeletal, Fast 2 3
  • Myosin Light Chain Alkali 1/2 3 4
  • Myosin Light Chain A1/A2 3 4
  • MLC1F/MLC3F 3 4
  • MLC1/MLC3 3 4
  • A1 Catalytic 3
  • A2 Catalytic 3
  • MLC1F 3
  • MLC3F 3

External Ids for MYL1 Gene

Previous GeneCards Identifiers for MYL1 Gene

  • GC02M209430
  • GC02M209879
  • GC02M211118
  • GC02M211357
  • GC02M210980
  • GC02M210863
  • GC02M203000

Summaries for MYL1 Gene

Entrez Gene Summary for MYL1 Gene

  • Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYL1 Gene

MYL1 (Myosin Light Chain 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and Activation of cAMP-Dependent PKA. GO annotations related to this gene include calcium ion binding and structural constituent of muscle. An important paralog of this gene is MYL3.

UniProtKB/Swiss-Prot for MYL1 Gene

  • Regulatory light chain of myosin. Does not bind calcium.

Tocris Summary for MYL1 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.

Gene Wiki entry for MYL1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL1 Gene

Genomics for MYL1 Gene

Regulatory Elements for MYL1 Gene

Enhancers for MYL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MYL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MYL1 Gene

Chromosome:
2
Start:
210,290,144 bp from pter
End:
210,315,190 bp from pter
Size:
25,047 bases
Orientation:
Minus strand

Genomic View for MYL1 Gene

Genes around MYL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL1 Gene

Proteins for MYL1 Gene

  • Protein details for MYL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05976-MYL1_HUMAN
    Recommended name:
    Myosin light chain 1/3, skeletal muscle isoform
    Protein Accession:
    P05976
    Secondary Accessions:
    • B2R4N6
    • B2R4T6
    • P06741
    • Q6IBD5

    Protein attributes for MYL1 Gene

    Size:
    194 amino acids
    Molecular mass:
    21145 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains.

    Alternative splice isoforms for MYL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYL1 Gene

Proteomics data for MYL1 Gene at MOPED

Post-translational modifications for MYL1 Gene

Other Protein References for MYL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYL1 Gene

Domains & Families for MYL1 Gene

Protein Domains for MYL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05976

UniProtKB/Swiss-Prot:

MYL1_HUMAN :
  • Contains 3 EF-hand domains.
Domain:
  • Contains 3 EF-hand domains.
genes like me logo Genes that share domains with MYL1: view

Function for MYL1 Gene

Molecular function for MYL1 Gene

GENATLAS Biochemistry:
myosin,light polypeptide 1,alkali;skeletal,fast,same as MLC1-F & MLC3-F
UniProtKB/Swiss-Prot Function:
Regulatory light chain of myosin. Does not bind calcium.
genes like me logo Genes that share phenotypes with MYL1: view

Animal Models for MYL1 Gene

MGI Knock Outs for MYL1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MYL1 Gene

Localization for MYL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYL1 Gene COMPARTMENTS Subcellular localization image for MYL1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0030016 myofibril IDA 8145163
GO:0043292 contractile fiber IEA --
genes like me logo Genes that share ontologies with MYL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYL1 Gene

Pathways & Interactions for MYL1 Gene

genes like me logo Genes that share pathways with MYL1: view

Gene Ontology (GO) - Biological Process for MYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060048 cardiac muscle contraction IEA --
genes like me logo Genes that share ontologies with MYL1: view

No data available for SIGNOR curated interactions for MYL1 Gene

Drugs & Compounds for MYL1 Gene

(1) Drugs for MYL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(5) Additional Compounds for MYL1 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-Blebbistatin
674289-55-5
(R)-(+)-Blebbistatin
1177356-70-5
(S)-(-)-Blebbistatin
856925-71-8
ML 9 hydrochloride
105637-50-1
W-7 hydrochloride
61714-27-0

(5) Tocris Compounds for MYL1 Gene

Compound Action Cas Number
(+-)-Blebbistatin Selective inhibitor of myosin II ATPase activity 674289-55-5
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 1177356-70-5
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760) 856925-71-8
ML 9 hydrochloride Myosin light chain kinase inhibitor 105637-50-1
W-7 hydrochloride Calmodulin antagonist. Inhibits myosin light chain kinase 61714-27-0
genes like me logo Genes that share compounds with MYL1: view

Transcripts for MYL1 Gene

mRNA/cDNA for MYL1 Gene

Unigene Clusters for MYL1 Gene

Myosin, light chain 1, alkali; skeletal, fast:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYL1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: - - -
SP3: - - - - - - -
SP4: -

Relevant External Links for MYL1 Gene

GeneLoc Exon Structure for
MYL1
ECgene alternative splicing isoforms for
MYL1

Expression for MYL1 Gene

mRNA expression in normal human tissues for MYL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYL1 Gene

This gene is overexpressed in Muscle - Skeletal (x51.9).

Protein differential expression in normal tissues from HIPED for MYL1 Gene

This gene is overexpressed in Esophagus (24.2), Tonsil (16.8), and Oral epithelium (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYL1 Gene



SOURCE GeneReport for Unigene cluster for MYL1 Gene Hs.187338

genes like me logo Genes that share expression patterns with MYL1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MYL1 Gene

Orthologs for MYL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYL1 35
  • 92.5 (n)
  • 95.29 (a)
MYL1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYL1 35
  • 93.78 (n)
  • 97.93 (a)
MYL1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myl1 35
  • 88.54 (n)
  • 93.75 (a)
Myl1 16
Myl1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYL1 35
  • 97.74 (n)
  • 97.92 (a)
MYL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myl1 35
  • 87.29 (n)
  • 94.37 (a)
oppossum
(Monodelphis domestica)
Mammalia MYL1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYL1 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYL1 35
  • 78.89 (n)
  • 80.67 (a)
MYL1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYL1 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75774 35
myl1 35
  • 80.25 (n)
  • 85.99 (a)
African clawed frog
(Xenopus laevis)
Amphibia myl1-prov 35
zebrafish
(Danio rerio)
Actinopterygii myl1 35
  • 67.3 (n)
  • 63.52 (a)
myl1 36
  • 64 (a)
OneToMany
mylz3 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mlc-c 37
  • 53 (a)
Mlc-c 36
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T12D8.6 37
  • 48 (a)
mlc-5 36
  • 47 (a)
ManyToMany
mlc-6 36
  • 48 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL030C 35
  • 50.51 (n)
  • 40.15 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F10439g 35
  • 50.5 (n)
  • 40.3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MLC1 35
  • 50.25 (n)
  • 38.97 (a)
MLC1 36
  • 35 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU06617 35
  • 44.29 (n)
  • 34.27 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdc4 35
  • 49.12 (n)
  • 39.85 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.211 36
  • 60 (a)
ManyToMany
CSA.4806 36
  • 46 (a)
ManyToMany
CSA.6288 36
  • 46 (a)
ManyToMany
CSA.6678 36
  • 46 (a)
ManyToMany
Species with no ortholog for MYL1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYL1 Gene

ENSEMBL:
Gene Tree for MYL1 (if available)
TreeFam:
Gene Tree for MYL1 (if available)

Paralogs for MYL1 Gene

Paralogs for MYL1 Gene

(18) SIMAP similar genes for MYL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MYL1: view

Variants for MYL1 Gene

Sequence variations from dbSNP and Humsavar for MYL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1803984 -- 210,290,340(-) ACTCC(C/T)TGAAT utr-variant-3-prime
rs1963089 -- 210,292,963(+) GCTTG(A/G)CTAAG intron-variant
rs1995835 -- 210,294,785(+) TAAGT(G/T)TTAGC intron-variant
rs1995836 -- 210,294,947(+) TTCCC(A/G/T)TTCTT intron-variant
rs1057219 -- 210,298,481(-) CGAGC(C/T)CTGGG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MYL1 Gene

Variant ID Type Subtype PubMed ID
nsv834520 CNV Loss 17160897
nsv875767 CNV Gain 21882294

Variation tolerance for MYL1 Gene

Residual Variation Intolerance Score: 55.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MYL1 Gene

Disorders for MYL1 Gene

Relevant External Links for MYL1

Genetic Association Database (GAD)
MYL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYL1

No disorders were found for MYL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYL1 Gene

Publications for MYL1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. (PMID: 2304459) Hailstones D.L. … Gunning P.W. (Mol. Cell. Biol. 1990) 2 3
  3. Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter. (PMID: 3422212) Cohen-Haguenauer O. … FrAczal J. (Hum. Genet. 1988) 2 3
  4. Src Family Kinases (SFK) Mediate Angiotensin II-Induced Myosin Light Chain Phosphorylation and Hypertension. (PMID: 26011449) Qin B. … Zhou J. (PLoS ONE 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for MYL1 Gene

Sources for MYL1 Gene

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