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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYL1 Gene

protein-coding   GIFtS: 63
GCID: GC02M211118

Myosin, Light Chain 1, Alkali; Skeletal, Fast

(Previous names: myosin, light polypeptide 1, alkali; skeletal, fast)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Myosin, Light Chain 1, Alkali; Skeletal, Fast1 2     MLC1F2
Myosin, Light Polypeptide 1, Alkali; Skeletal, Fast1 2     MLC3F2
Myosin Light Chain A1/A22 3     A1 Catalytic2
Myosin Light Chain Alkali 1/22 3     A2 Catalytic2
MLC1/MLC32 3     Myosin Light Chain 1/3, Skeletal Muscle Isoform2
MLC1F/MLC3F2 3     

External Ids:    HGNC: 75821   Entrez Gene: 46322   Ensembl: ENSG000001685307   OMIM: 1607805   UniProtKB: P059763   

Export aliases for MYL1 gene to outside databases

Previous GC identifers: GC02M209430 GC02M209879 GC02M211357 GC02M210980 GC02M210863 GC02M203000


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYL1 Gene:
Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable
alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light
chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for MYL1 Gene: 
MYL1 (myosin, light chain 1, alkali; skeletal, fast) is a protein-coding gene. Diseases associated with MYL1 include rhabdomyosarcoma, and influenza, and among its related super-pathways are Striated Muscle Contraction and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include structural constituent of muscle and calcium ion binding. An important paralog of this gene is MYL4.

UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976
Function: Regulatory light chain of myosin. Does not bind calcium

summary for MYL1 Gene:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYL1 gene promoter:
         ER-alpha   STAT2   STAT1beta   c-Myb   Tal-1beta   STAT1alpha   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MYL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MYL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33-q34   Ensembl cytogenetic band:  2q34   HGNC cytogenetic band: 2q33-q34

MYL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M211118:  view genomic region     (about GC identifiers)

Start:
211,154,868 bp from pter      End:
211,179,914 bp from pter
Size:
25,047 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976 (See protein sequence)
Recommended Name: Myosin light chain 1/3, skeletal muscle isoform  
Size: 194 amino acids; 21145 Da
Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains
Secondary accessions: B2R4N6 B2R4T6 P06741 Q6IBD5
Alternative splicing: 2 isoforms:  P05976-1   P05976-2, P06741-1   (Initiator Met-1 is removed. Contains a N-acetylalanine at position 2 (By similarity))

Explore the universe of human proteins at neXtProt for MYL1: NX_P05976

Explore proteomics data for MYL1 at MOPED 

Post-translational modifications:

  • UniProtKB: Isoform MLC3 is acetylated at position 2 (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P05976

  • MYL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MYL1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_524144.1  NP_524146.1  

    ENSEMBL proteins: 
     ENSP00000343321   ENSP00000307280  
    Reactome Protein details: P05976
    Human Recombinant Protein Products for MYL1: 
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    Novus Biologicals MYL1 Proteins
    Novus Biologicals MYL1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MYL1
    Cloud-Clone Corp. Proteins for MYL1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005859muscle myosin complex NAS3904738
    GO:0030016myofibril IDA8145163
    GO:0030017sarcomere NAS3904738
    GO:0043292contractile fiber ----

    MYL1 for ontologies           About GeneDecksing



    MYL1 Antibody Products: 
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    Assay Products for MYL1: 
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    Cloud-Clone Corp. ELISAs for MYL1 
    Cloud-Clone Corp. CLIAs for MYL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing
    MYL: Myosins / Light chain

    2 InterPro protein domains:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom

    Graphical View of Domain Structure for InterPro Entry P05976

    ProtoNet protein and cluster: P05976

    UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976
    Similarity: Contains 3 EF-hand domains


    MYL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYL1_HUMAN, P05976
    Function: Regulatory light chain of myosin. Does not bind calcium

         Genatlas biochemistry entry for MYL1:
    myosin,light polypeptide 1,alkali;skeletal,fast,same as MLC1-F & MLC3-F

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0008307structural constituent of muscle NAS3904738
         
    MYL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MYL1:
     Increased G1 DNA content 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Myl1):
     behavior/neurological  cellular  embryogenesis  growth/size  mortality/aging 
     muscle  nervous system  normal  skeleton 

    MYL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Myl1tm1Nros for MYL1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MYL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MYL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYL1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYL1 

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MYL1
    SwitchGear 3'UTR luciferase reporter plasmidMYL1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of MYL1

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): MYL1 (NM_079422)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MYL1 About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Striated Muscle Contraction
    Striated Muscle Contraction0.87
    Muscle contraction0.65
    Striated Muscle Contraction0.87
    2Immune response CCR3 signaling in eosinophils
    Immune response CCR3 signaling in eosinophils0.51
    Inhibitory action of Lipoxins on neutrophil migration0.51
    3Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    4PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    5Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin-mediated cell adhesion and migration0.49
    Cell adhesion Tight junctions0.33
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 EMD Millipore Pathways for MYL1 (see all 7)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils

    5/16 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYL1 (see all 16)
        Activation of PKA through GPCR
    RhoA Pathway
    PKA Signaling
    Guidance Cues and Growth Cone Motility
    Antioxidant Action of Vitamin-C

    5/8 GeneGo (Thomson Reuters) Pathways for MYL1 (see all 8)
        Signal transduction Activation of PKC via G-Protein coupled receptor
    Cell adhesion Integrin-mediated cell adhesion and migration
    Inhibitory action of Lipoxins on neutrophil migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils

    4 BioSystems Pathways for MYL1
        G13 Signaling Pathway
    Regulation of Actin Cytoskeleton
    Striated Muscle Contraction
    Endothelin

    2        Reactome Pathways for MYL1
        Muscle contraction
    Striated Muscle Contraction



    MYL1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    43/50 Interacting proteins for MYL1 (P059763 ENSP000003072804) via UniProtKB, MINT, STRING, and/or I2D (see all 50) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPB41P111713, ENSP000002901004I2D: score=1 STRING: ENSP00000290100
    ACTA1P681333, ENSP000003556454I2D: score=1 STRING: ENSP00000355645
    ACTA2P627363, ENSP000002247844I2D: score=1 STRING: ENSP00000224784
    IL7RP168713I2D: score=1 
    SLC2A4P146723I2D: score=1 
    ACTN2ENSP000003555374STRING: ENSP00000355537
    DESENSP000003630714STRING: ENSP00000363071
    DMDENSP000003549234STRING: ENSP00000354923
    MYBPC1ENSP000003548494STRING: ENSP00000354849
    MYBPC2ENSP000003503324STRING: ENSP00000350332
    MYBPC3ENSP000003821934STRING: ENSP00000382193
    MYH3ENSP000002262094STRING: ENSP00000226209
    MYL2ENSP000002288414STRING: ENSP00000228841
    MYL3ENSP000002923274STRING: ENSP00000292327
    MYL4ENSP000003470554STRING: ENSP00000347055
    NEBENSP000003862594STRING: ENSP00000386259
    TCAPENSP000003126244STRING: ENSP00000312624
    TNNC2ENSP000003616364STRING: ENSP00000361636
    TNNI1ENSP000003370224STRING: ENSP00000337022
    TNNI2ENSP000002528984STRING: ENSP00000252898
    TNNI3ENSP000003418384STRING: ENSP00000341838
    TNNT1ENSP000002919014STRING: ENSP00000291901
    TNNT3ENSP000002783174STRING: ENSP00000278317
    TPM1ENSP000002679964STRING: ENSP00000267996
    TPM2ENSP000003542194STRING: ENSP00000354219
    TPM4ENSP000003452304STRING: ENSP00000345230
    VIMENSP000002242374STRING: ENSP00000224237
    TMOD1ENSP000002593654STRING: ENSP00000259365
    MYH1ENSP000002262074STRING: ENSP00000226207
    MYH11ENSP000003796164STRING: ENSP00000379616
    MYH13ENSP000002521724STRING: ENSP00000252172
    MYH2ENSP000002455034STRING: ENSP00000245503
    MYH4ENSP000002553814STRING: ENSP00000255381
    MYH6ENSP000003486344STRING: ENSP00000348634
    MYH7ENSP000003475074STRING: ENSP00000347507
    MYL5ENSP000003830234STRING: ENSP00000383023
    MYL6BENSP000002074374STRING: ENSP00000207437
    MYL9ENSP000002790224STRING: ENSP00000279022
    MYLPFENSP000003252394STRING: ENSP00000325239
    MYOM1ENSP000003488214STRING: ENSP00000348821
    MYH10ENSP000002692434STRING: ENSP00000269243
    MYH9ENSP000002161814STRING: ENSP00000216181
    MYL12BENSP000002375004STRING: ENSP00000237500
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction IDA8145163
    GO:0007517muscle organ development NAS--
    GO:0030049muscle filament sliding TAS--
    GO:0060048cardiac muscle contraction IEA--

    MYL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MYL1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BTSSelective inhibitor of skeletal muscle myosin II ATPase activity[1576-37-0]
    (R)-(+)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)[1177356-70-5]
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)[856925-71-8]
    (+-)-BlebbistatinSelective inhibitor of myosin II ATPase activity[674289-55-5]

    1 HMDB Compound for MYL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about MYL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYL1 gene (2 alternative transcripts): 
    NM_079420.2  NM_079422.2  

    Unigene Cluster for MYL1:

    Myosin, light chain 1, alkali; skeletal, fast
    Hs.187338  [show with all ESTs]
    Unigene Representative Sequence: BF790783
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341685(uc002veb.3) ENST00000352451(uc002vec.3) ENST00000496436
    ENST00000484290
    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYL1

    Additional mRNA sequence: 

    AK311892.1 AK311942.1 BC005318.1 CR456869.1 M20643.1 X05451.1 

    11 DOTS entries:

    DT.451890  DT.100646912  DT.95136953  DT.120988964  DT.92458835  DT.100646906  DT.87046784  DT.100028901 
    DT.120988967  DT.120988980  DT.92012066 

    24/414 AceView cDNA sequences (see all 414):

    CR598137 F28438 F35245 BM720926 W92584 F30858 F25010 BM697229 
    F31880 AA176940 AL598940 F29303 BU735911 F34766 BF589612 AU099573 
    F35530 F27414 F30560 F32732 F29961 BM678556 BU581245 N69926 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MYL1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                                        
    SP2:                    -     -     -                                       
    SP3:              -     -     -     -     -     -     -                     
    SP4:                          -                                             


    ECgene alternative splicing isoforms for MYL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYL1 expression in normal human tissues (normalized intensities)      MYL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCAACAAA
    MYL1 Expression
    About this image


    MYL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 10 entries
             Mononuclear Myocytes Hyoid Arch Muscles
             Human Skeletal Muscle Satellite Cells (HSkMSC)   
             cavities and their linings/intraembryonic coelom/diaphragm   
     
     Limb (Muscoskeletal System)    fully expand to see all 6 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod
             limb/hindlimb/leg   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Long Bone
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cardiomyocytes Atrial Septum
     
     Smooth Muscle (Muscoskeletal System)
             Human Bladder Smooth Muscle Cells (HBdSMC)   

    See MYL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYL1

    SOURCE GeneReport for Unigene cluster: Hs.187338
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYL1 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myl11 , 5 myosin, light polypeptide 11, 5 87.94(n)1
    94.15(a)1
      1 (33.71 cM)5
    179011  NM_021285.31  NP_067260.11 
     669242955 
    chicken
    (Gallus gallus)
    Aves MYL11 myosin, light chain 1, alkali; skeletal, fast 78.89(n)
    80.67(a)
      396470  NM_001044632.1  NP_001038097.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYL16
    Uncharacterized protein
    84(a)
    1 ↔ 1
    1(113465920-113497825)
    African clawed frog
    (Xenopus laevis)
    Amphibia myl1-prov2 myosin light chain, alkali, fast skeletal muscle 79.94(n)    L38596.1 
    zebrafish
    (Danio rerio)
    Actinopterygii myl11 myosin, light chain 1, alkali; skeletal, fast 66.67(n)
    64.74(a)
      336165  NM_200000.1  NP_956294.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mlc-c3 myosin ATPase 53(a)   5A8   --
    worm
    (Caenorhabditis elegans)
    Secernentea T12D8.63
    mlc-31
    EF hand3
    Protein MLC-31
    48(a)3
    53.66(n)1
    45.39(a)1
      III(13694513-13695376)3
    1757681  NM_171128.61  NP_741145.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MLC11 Mlc1p 50.49(n)
    38.97(a)
      852772   NP_011409.1 


    ENSEMBL Gene Tree for MYL1 (if available)
    TreeFam Gene Tree for MYL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYL1 gene
    MYL42  MYL6B2  MYL62  MYL32  
    18 SIMAP similar genes for MYL1 using alignment to 3 protein entries:     MYL1_HUMAN (see all proteins):
    MYL6    MYL3    MYL4    MYL6B    CALML3    CALM3
    CALM1    CALM2    CETN2    CABP1    CETN1    TNNC2
    CALML5    TNNC1    EFCAB2    CABP2    CALML6    CETN3

    MYL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/596 SNPs in MYL1 are shown (see all 596)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1837718571,2
    --211154446(+) CCATCA/CCAGAG 2 -- ds50010--------
    rs1905540361,2
    --211154559(+) ATTGTC/TACTAG 2 -- ds50010--------
    rs130202321,2
    C,F,H--211154625(+) GTTTTC/TGCTTT 2 -- ds500113Minor allele frequency- T:0.07NS EA NA WA 1056
    rs1822277871,2
    C--211154753(+) GTAGAC/TTTCAG 2 -- ds50010--------
    rs1867702861,2
    --211154989(+) TTCTCA/TTCTAG 2 -- ut310--------
    rs1916936021,2
    --211155050(+) GAAGAC/TGTATA 2 -- ut310--------
    rs1814848991,2
    --211155085(+) TGAACC/TGTCCA 2 -- ut310--------
    rs758797361,2
    F--211155308(+) CACTTA/GCAAGA 2 -- int11Minor allele frequency- G:0.01WA 118
    rs766711231,2
    C,F--211155321(+) AGCCAA/GTTCCT 2 -- int11Minor allele frequency- G:0.04WA 118
    rs1154803461,2
    F--211155648(+) ATCTCG/ATAATT 2 -- int11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for MYL1 (211154868 - 211179914 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MYL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834520CNV Loss17160897
    nsv875767CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 160780    OMIM disorders: --

    4 diseases for MYL1:    About MalaCards
    rhabdomyosarcoma    influenza    laryngitis    ischemia


    MYL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MYL1

    Export disorders for MYL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYL1 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with MYL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. (PubMed id 2304459)1, 3 Hailstones D.L. and Gunning P.W. (1990)
    3. Identification of the functional promoter regions in the human gene encoding the myosin alkali light chains MLC1 and MLC3 of fast skeletal muscle. (PubMed id 2777779)1, 2 Seidel U. and Arnold H.H. (1989)
    4. Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter. (PubMed id 3422212)1, 3 Cohen-Haguenauer O....Frezal J. (1988)
    5. Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms. (PubMed id 2458299)1, 2 Seidel U.... Arnold H.H. (1988)
    6. The complete nucleotide sequences of cDNA clones coding for human myosin light chains 1 and 3. (PubMed id 3601661)1, 2 Seidel U.... Arnold H.H. (1987)
    7. The MLK-related kinase (MRK) is a novel RhoC effector that mediates lysophosphatidic acid (LPA)-stimulated tumor cell invasion. (PubMed id 23319595)1 Korkina O....Ruggieri R. (2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4632 HGNC: 7582 AceView: MYL1 Ensembl:ENSG00000168530 euGenes: HUgn4632
    ECgene: MYL1 H-InvDB: MYL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYL1 gene:
    Search GeneIP for patents involving MYL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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