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MYH9 Gene

protein-coding   GIFtS: 72
GCID: GC22M036677

Myosin, Heavy Chain 9, Non-Muscle

(Previous names: myosin, heavy polypeptide 9, non-muscle)
(Previous symbol: DFNA17)
  See MYH9-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin, Heavy Chain 9, Non-Muscle1 2     FTNS2 5
DFNA171 2 5     MHA2 5
Nonmuscle Myosin Heavy Chain II-A1 2     Myosin, Heavy Polypeptide 9, Non-Muscle1
Cellular Myosin Heavy Chain, Type A2 3     EPSTS2
Myosin Heavy Chain 92 3     NMHC-II-A2
Myosin Heavy Chain, Non-Muscle IIa2 3     NMMHCA2
Non-Muscle Myosin Heavy Chain A2 3     myosin-92
Non-Muscle Myosin Heavy Chain IIa2 3     Non-Muscle Myosin Heavy Polypeptide 92
NMMHC-IIA2 3     NMMHC-A3
BDPLT62 5     NMMHC II-A3

External Ids:    HGNC: 75791   Entrez Gene: 46272   Ensembl: ENSG000001003457   OMIM: 1607755   UniProtKB: P355793   

Export aliases for MYH9 gene to outside databases

Previous GC identifers: GC22M033322 GC22M034949 GC22M035001 GC22M019645


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYH9 Gene:
This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional
myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and
a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility
and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural
deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian
syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. (provided by
RefSeq, Dec 2011)

GeneCards Summary for MYH9 Gene:
MYH9 (myosin, heavy chain 9, non-muscle) is a protein-coding gene. Diseases associated with MYH9 include myh9-related disorders, and myh9 related thrombocytopenia. GO annotations related to this gene include calmodulin binding and protein homodimerization activity. An important paralog of this gene is MYH8.

UniProtKB/Swiss-Prot: MYH9_HUMAN, P35579
Function: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such
as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal
contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction;
this function is mechanically antagonized by MYH10

summary for MYH9 Gene:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYH9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYH9 gene promoter:
         Max1   USF1   MyoD   Tal-1beta   E47   c-Ets-1   USF-1   Cart-1   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MYH9 promoter sequence
   Search Chromatin IP Primers for MYH9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYH9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q13.1

MYH9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYH9 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M036677:  view genomic region     (about GC identifiers)

Start:
36,677,323 bp from pter      End:
36,784,063 bp from pter
Size:
106,741 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MYH9_HUMAN, P35579 (See protein sequence)
Recommended Name: Myosin-9  
Size: 1960 amino acids; 226532 Da
Subunit: Interacts with PDLIM2 (By similarity). Interacts with SLC6A4 (By similarity). Myosin is a hexameric
protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light
chain subunits (MLC-2). Interacts with RASIP1. Interacts with DDR1 (By similarity). Interacts with SVIL and HTRA3
Sequence caution: Sequence=CAD89954.1; Type=Frameshift; Positions=1890;
3 PDB 3D structures from and Proteopedia for MYH9:
2LNK (3D)        3ZWH (3D)        4ETO (3D)    
Secondary accessions: A8K6E4 O60805 Q60FE2 Q86T83
Alternative splicing: 2 isoforms:  P35579-1   P35579-2   

Explore the universe of human proteins at neXtProt for MYH9: NX_P35579

Explore proteomics data for MYH9 at MOPED

Post-translational modifications: 

  • ISGylated1
  • Ubiquitination2 at Lys8, Lys14, Lys38, Lys102, Lys186, Lys225, Lys261, Lys299, Lys373, Lys403,
                                 Lys637, Lys651, Lys682, Lys760, Lys810, Lys833, Lys835, Lys1234, Lys1392, Lys1445 (see all 21)
  • Modification sites at PhosphoSitePlus

  • See MYH9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002464.1  
    ENSEMBL proteins: 
     ENSP00000216181   ENSP00000384631   ENSP00000414852  
    Reactome Protein details: P35579

    MYH9 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MYH9
    GenScript Custom Purified and Recombinant Proteins Services for MYH9
    Novus Biologicals MYH9 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYH9

     
    Search eBioscience for Proteins for MYH9 

     
    antibodies-online proteins for MYH9 (12 products) 

     
    antibodies-online peptides for MYH9

    MYH9 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MYH9
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for MYH9 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MYH9
    Novus Biologicals MYH9 Antibodies
    Abcam antibodies for MYH9
    Cloud-Clone Corp. Antibodies for MYH9
    ThermoFisher Antibody for MYH9
    antibodies-online antibodies for MYH9 (74 products) 

    MYH9 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MYH9
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MYH9
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MYH9
    Cloud-Clone Corp. CLIAs for MYH9
    Search eBioscience for ELISAs for MYH9 
    antibodies-online kits for MYH9 (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MYHII: Myosins / Myosin superfamily : Class II

    Selected InterPro protein domains (see all 7):
     IPR027401 Myosin-like_IQ_dom
     IPR004009 Myosin_N
     IPR027417 P-loop_NTPase
     IPR000048 IQ_motif_EF-hand-BS
     IPR002928 Myosin_tail

    Graphical View of Domain Structure for InterPro Entry P35579

    ProtoNet protein and cluster: P35579

    4 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB002017 Spectrin repeat
    IPB002928 Myosin tail
    IPB004009 Myosin N-terminal SH3-like domain


    UniProtKB/Swiss-Prot: MYH9_HUMAN, P35579
    Domain: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of
    4 heptapeptides, characteristic for alpha-helical coiled coils
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 myosin head-like domain


    Find genes that share domains with MYH9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYH9_HUMAN, P35579
    Function: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such
    as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal
    contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction;
    this function is mechanically antagonized by MYH10

         Genatlas biochemistry entry for MYH9:
    myosin,motor contractile protein moving towards the "plus" end of actin track,heavy polypeptide 9,non muscle

         Gene Ontology (GO): Selected molecular function terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000146microfilament motor activity IDA12237319
    GO:0000166nucleotide binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003774motor activity NAS12421915
    GO:0003779actin binding IDA15065866
         
    Find genes that share ontologies with MYH9           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MYH9:
     Increased focal adhesion (FA)   Large cells 

         13 MGI mutant phenotypes (inferred from 16 alleles(MGI details for Myh9):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hearing/vestibular/ear 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  nervous system 
     normal  renal/urinary system  vision/eye 

    Find genes that share phenotypes with MYH9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MYH9: Myh9tm1.2Gac Myh9tm1Maco

       genOway: Develop your customized and physiologically relevant rodent model for MYH9

    miRNA
    Products:
        
    miRTarBase miRNAs that target MYH9:
    hsa-mir-193b-3p (MIRT041494), hsa-mir-1296-5p (MIRT036109), hsa-mir-324-3p (MIRT042922), hsa-mir-9-5p (MIRT021471), hsa-mir-149-5p (MIRT045466), hsa-mir-484 (MIRT042190), hsa-mir-124-3p (MIRT002579), hsa-mir-877-3p (MIRT037181), hsa-mir-92a-3p (MIRT049384), hsa-mir-331-3p (MIRT043426)

    Block miRNA regulation of human, mouse, rat MYH9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYH9 (see all 47):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-300 hsa-miR-376b hsa-miR-25 hsa-miR-449a hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidMYH9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MYH9
    Predesigned siRNA for gene silencing in human, mouse, rat MYH9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MYH9

    Clone
    Products:
         
    OriGene clones in human, mouse for MYH9 (see all 5)
    OriGene ORF clones in mouse, rat for MYH9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYH9 (NM_002473)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYH9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYH9
    Addgene plasmids for MYH9 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MYH9
    Browse ESI BIO Cell Lines and PureStem Progenitors for MYH9 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYH9_HUMAN, P35579: Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cell cortex (By similarity).
    Note=Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    extracellular5
    nucleus5
    plasma membrane5
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IDA14508515
    GO:0001726ruffle IDA16403913
    GO:0001772colocalizes with immunological synapse IDA15064761
    GO:0001931uropod IDA15064761
    GO:0005634nucleus IDA14508515

    Find genes that share ontologies with MYH9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYH9 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    2Cell adhesion Integrin mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Development MAG dependent inhibition of neurite outgrowth0.46
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cell adhesion Tight junctions0.33
    3PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    4Semaphorin interactions
    Sema4D in semaphorin signaling0.90
    Semaphorin interactions0.43
    Sema4D induced cell migration and growth-cone collapse0.90
    5Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77


    Find genes that share SuperPaths with MYH9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYH9 (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions

    1 Cell Signaling Technology (CST) Pathway for MYH9
        Cytoskeletal Signaling

    Selected GeneGo (Thomson Reuters) Pathways for MYH9 (see all 6)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Tight junctions

    2 Reactome Pathways for MYH9
        Sema4D induced cell migration and growth-cone collapse
    Regulation of actin dynamics for phagocytic cup formation


    3 Kegg Pathways  (Kegg details for MYH9):
        Tight junction
    Regulation of actin cytoskeleton
    Salmonella infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MYH9: 
              Cell Surface Markers in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MYH9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYH9 (P355791, 2, 3 ENSP000002161814) via UniProtKB, MINT, STRING, and/or I2D (see all 1109)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCLP193381, 2, 3, ENSP000003181954EBI-350338,EBI-346967 MINT-7945693 I2D: score=2 STRING: ENSP00000318195
    YWHAZP631042, 3, ENSP000003095034MINT-7899812 MINT-7900157 I2D: score=2 STRING: ENSP00000309503
    COPS5Q929052, 3, ENSP000003505124MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000350512
    LMNAP025452, 3MINT-7945693 MINT-7899812 MINT-7947479 I2D: score=1 
    YWHAQP273482, 3, ENSP000002380814MINT-7899812 MINT-7900157 I2D: score=1 STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000212meiotic spindle organization IEA--
    GO:0000904cell morphogenesis involved in differentiation ----
    GO:0000910cytokinesis IMP15774463
    GO:0001525angiogenesis IDA16403913
    GO:0001701in utero embryonic development IEA--

    Find genes that share ontologies with MYH9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MYH9 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BTSSelective inhibitor of skeletal muscle myosin II ATPase activity[1576-37-0]
    (R)-(+)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)[1177356-70-5]
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)[856925-71-8]
    (+-)-BlebbistatinSelective inhibitor of myosin II ATPase activity[674289-55-5]

    4 Novoseek inferred chemical compound relationships for MYH9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phorbol 21.5 1 15496418 (1)
    calcium 0 1 18312684 (1)
    threonine 0 1 10945986 (1)
    tyrosine 0 1 19401332 (1)



    Find genes that share compounds with MYH9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYH9 gene: 
    NM_002473.4  

    Unigene Cluster for MYH9:

    Myosin, heavy chain 9, non-muscle
    Hs.474751  [show with all ESTs]
    Unigene Representative Sequence: NM_002473
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216181(uc003apg.3 uc003aph.1) ENST00000475726 ENST00000486218
    ENST00000459960 ENST00000495928 ENST00000473022 ENST00000477189 ENST00000472210
    ENST00000463027 ENST00000401701(uc003api.1) ENST00000456729
    miRNA
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    Block miRNA regulation of human, mouse, rat MYH9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYH9 (see all 47):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-300 hsa-miR-376b hsa-miR-25 hsa-miR-449a hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidMYH9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MYH9
    Clone
    Products:
         
    OriGene clones in human, mouse for MYH9 (see all 5)
    OriGene ORF clones in mouse, rat for MYH9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYH9 (NM_002473)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYH9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYH9
    Addgene plasmids for MYH9 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MYH9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYH9
      QuantiTect SYBR Green Assays in human, mouse, rat MYH9
      QuantiFast Probe-based Assays in human, mouse, rat MYH9

    Additional mRNA sequence: 

    AB191263.1 AB290175.1 AK025219.1 AK025393.1 AK131080.1 AK291609.1 AK304840.1 BC011915.2 
    BC049849.1 BC090921.1 BC111387.1 BC113067.1 BC131741.1 CR456526.1 D11393.1 HQ326701.1 
    L29141.1 M31013.1 M69180.1 M81105.1 

    Selected DOTS entries (see all 58):

    DT.95126859  DT.119239  DT.92464957  DT.95347813  DT.97761844  DT.100659644  DT.100659636  DT.100659653 
    DT.91985714  DT.120655569  DT.95347783  DT.120655540  DT.100659655  DT.120655825  DT.120655658  DT.100659642 
    DT.120655748  DT.120655676  DT.91811745  DT.100659641  DT.102840742  DT.95347683  DT.97867641  DT.120655554 

    1191 AceView cDNA sequences (see top 24):

    AW511520 CF137349 BE311756 BF806147 BQ433063 BQ440052 H55296 BG990930 
    AI908004 AK131080 BQ890597 AI431976 BQ672665 BQ232553 AA856897 CA429318 
    BQ007816 AI582363 W23678 BQ773542 BU538565 BM454409 CF454148 BM472152 
    BU194005 BU169188 BQ920939 BQ063361 BU632240 BM550064 AI130989 NM_002473 
    AW236311 AI244463 CK000662 BQ709199 BM679196 BE220516 BU501143 CN483643 
    AW004952 BQ447005 BU626369 BQ674719 CA415838 BG325739 AI539529 BC011915 
    BQ901018 AI925868 AI809282 BU169233 M81105 AW029244 AW576206 BQ310770 
    AW316817 CA430467 BU500273 CD614947 BG699149 BQ897174 BI028048 CB530035 
    BQ009961 AW440032 BQ876769 BF839762 AI826560 BQ707568 AW192310 BE391274 
    AI539761 CB148769 BQ068827 BQ947257 CA388984 AI439449 BU527440 CA946519 
    BE466261 BQ688338 AW167491 AA862609 BG236842 AI925405 BX279595 BG476345 
    AW583843 BM996239 L29141 BF689443 AA658253 BP366150 BQ936372 BQ439839 
    AW501036 BU625874 BI020066 BM469607 CD369796 AA070714 BQ301342 BQ924960 
    CK001013 BM476409 AW166606 BP336105 CA392559 AW152567 BG987750 BU623186 
    BE795516 BF445713 AW511726 BQ876698 BF847906 BU860353 BG678160 BG121668 
    BU528520 CR456526 AI919066 BQ882158 CA442197 BM469206 BU157997 BC049849 
    BP364042 BQ641343 AI699765 AW768361 BE909790 AI669260 AW192058 CF132459 
    BI493791 BX485568 BQ058956 BM763977 BU838888 AI859664 AW950092 BU622803 
    AI024498 AA470782 AA666146 BQ071227 CF995724 BQ944910 BQ949657 BM471204 
    BF475577 CN481323 CB216472 AI287313 CN484067 AW008451 BU501267 BU509830 
    BE390204 AA041529 BV205826 BE876541 BQ045191 CF143367 BM763529 AW440867 
    BQ053015 BQ347397 BG398208 BM852115 AI983389 BF847852 BG337374 CD364757 
    BQ775804 AI124004 AW303884 BM970229 AW352426 BQ318541 BU187952 BG938519 
    AU133747 BG252185 BG744355 BE940095 BG110785 AI888584 BG987805 BE313589 
    AA380287 BQ692010 AA402384 BE741250 BF055360 AA983405 BG035451 BE562721 
    AL135586 CN482567 CF619352 W44896 BI022186 AI363951 BF854060 BF972808 
    CA448486 BQ960469 BF734153 BG386641 BG992405 BU186512 BP364266 BQ308716 
    BG034983 CK000160 AI971953 H84428 AW081108 BF761208 CN484220 BG744924 
    BG420803 BM914602 AW440074 CN481805 BF931112 BE544312 BF902189 BQ691886 
    BG393170 R69305 CB108751 CN481478 CD614931 AW167011 BQ922240 BQ712638 
    BQ347329 BG683302 AI806804 CN483852 AA420536 CD366269 BF817726 BG117818 
    BQ772676 BQ227296 BG327469 BQ710942 AI623886 BP346738 BP355695 AL601033 
    BM470655 AI478770 BG176719 BF373071 BG056055 BQ890473 BF379674 BM802935 
    BU630683 AI076254 CD614942 BG290735 BG698791 CA406852 AW375191 BP364489 
    CF785962 BI871437 AI888843 BG119376 BX641504 BQ017015 BQ688728 BU168101 
    BE908344 CD614943 BE932122 BQ894863 AI197861 BE299113 AI537058 BF734155 
    BG743168 BQ058454 BG481892 BP872931 BQ029036 BQ708391 AA570479 AA576376 
    BF853754 BI028132 BQ896816 BG720685 BI040998 BI834568 BQ002024 CB149275 
    BG757423 BV196170 BG389080 BE764575 BE875708 AI708620 AW858539 BG251566 
    CA428169 BU168334 BV174842 BP355485 BF310000 BG223325 BG762484 BG830163 
    BP353900 M69180 CB145596 BG385742 BG253593 BU179420 CA439735 BP348197 
    BF823638 BU507594 BQ073445 AA402632 BF971683 AI686872 AW117834 BQ941787 
    D11393 BI055462 AK025393 AI581646 BF794712 BE280315 BU500950 BF436655 
    BG992406 BQ773184 BU557942 AA666144 BG874461 BM009038 BE270159 BF853764 
    BG831743 BM543090 BF816704 BG746353 CA435660 AA680036 AI204036 CD723877 
    AW577005 BQ945858 BF734042 BI871692 BU147218 BI027270 BU147296 BQ930684 
    BQ946091 AI281296 AL596607 BQ771879 BF128351 BQ877837 BG479952 BE888904 
    BQ315808 CF138633 BG107625 BQ945735 BG825813 BF905338 BF810271 AI281297 
    BF873962 CA944482 BE810817 BF984218 BG248537 CA429156 N36094 AA687948 
    AI499149 BG765623 BI031184 CA445258 BQ070070 BE878452 BM463388 BQ685732 
    AI130911 BG824296 BP358273 BE677547 BG328333 BQ690080 BQ005913 BG759916 
    BU165949 M31013 BE673482 BM722709 BE712956 BG110373 BG828256 BQ014504 
    BE019166 BQ939705 W35111 AA877420 BU625808 BF127555 AW007015 BF854597 
    BP364199 BE875064 BQ901218 AW503956 AI936797 BF870531 BM468460 BU601866 
    BG478894 BE705868 BU627334 BG119392 BE327952 BG325379 N44098 AW780266 
    CD614939 BE742946 BU501635 BQ348607 BM801791 CA448746 BF976367 BE740460 
    BE388456 BI057175 BQ315807 BG753403 BG992401 BU528119 N34670 BF229253 
    BP336905 CA445338 CK000517 AI241191 CK000118 BF973782 BG327778 AW362194 
    AA523209 BU628587 CB148944 CD614951 BF872532 AI346948 BF847894 AI239875 
    M78027 BM542469 BU166899 BQ008708 CK000411 AW069624 BQ931357 BQ961976 
    BG327410 BQ007089 BQ890616 CA390243 BF765490 AW088016 BQ420906 AK025219 
    BI040368 BI062064 AL121451 BU191510 BF933043 BG752026 BG011080 BQ005090 
    BG120527 BI044199 BF996328 AI225161 AA318640 R60961 T27874 BU196228 
    BG256796 BG758224 AI419943 BG751252 BU618156 AL121003 CD614946 BF436593 
    AI537132 BG420724 BI038938 BE712994 BF941155 BE879728 BQ064264 BI869871 
    BP364022 BQ709441 BE927935 BE812423 AI982845 AI124988 AI285142 BQ958315 
    BM048625 AL832639 AI088420 AW375168 BM048307 AW732357 BQ347413 AI906087 
    BI031364 AW591024 AA906229 AW600806 AI799160 BG121064 BU191263 AA732476 
    BF851202 AA976143 BF851789 BE046145 BQ347521 BF810639 AA937214 BG950104 
    BI063694 CD703749 BF843570 AA352158 BG257998 BG756113 BG910601 BG420141 
    BE940105 AA299717 BE388213 AI582670 BG984126 BF734138 CD614948 AW189884 
    BG422440 AW375171 AI869830 BQ945523 AW351986 BF514519 BU621295 BF900981 
    AA676372 AW375175 BE395825 BG977852 N30600 BF992881 BX333977 BQ316512 
    AA806169 AW177078 CA428362 BI087412 AW375200 CD614950 BP355732 AI672216 
    BI028711 AA594036 BQ308575 BE874874 BF304650 AA889840 AW807358 BG117074 
    BF842548 BV174841 BG388440 AW502010 BE927894 BF851198 BF435586 AW500997 
    BI037168 AI911117 BG120501 BF761204 AW129022 BX414579 BG990934 BF688741 
    BE940107 AW150298 BG123013 BG938518 BI871282 CD614932 BE709714 BM542477 
    BE392265 BE812469 CD614929 AW078725 BM452997 BG036296 CD614938 BF899560 
    BM008410 BF761205 BI018434 AA284501 BE940098 H01328 AW337626 BG987760 
    BF873638 AA434519 AW362234 CA314548 AW375176 BF740423 BQ007920 BG747170 
    BG979491 CD614952 BE844177 AW080013 BQ360341 D45637 AW366068 AI571267 
    BV196003 BF734526 BE712935 BG117632 AI076362 CA406322 BU608690 BF770925 
    BG490004 CD640937 CF138389 BF814061 AW504889 AW362168 BG763538 H21978 
    AW352422 BF873957 BF816693 AA366597 BQ348608 AI952788 H44011 BP363314 
    BQ310812 BE844189 BQ347522 BF807130 BQ705872 CD614944 AI569176 BE349053 
    AW131209 BQ348612 BQ316508 AW075755 BF823650 AI885372 BM005864 BI200186 
    AW499777 AW190284 BE816428 CD614928 BI054535 BG027177 CD614949 T69926 
    BG979578 BF809283 BF815094 CA434454 BG951419 BF817963 AW366075 BF895465 
    BE408003 AI659179 AA557303 BQ348079 AA287229 BM994718 AW366067 BE620071 
    BF667036 AW366066 BU174207 AA363387 BE816409 AW366017 AW362171 BF685870 
    CD614945 BU431358 AW375165 AI125922 AI827941 BI018404 BF808454 BF906521 
    BX644754 BG118822 AI952679 BE812170 BG828766 BE298833 BE002784 BQ331728 
    BG979577 BI871527 BF816151 BG171394 BF815791 CD614937 BE816405 BI836598 
    BF964483 BG104233 BF869338 AW362209 AW366073 BE812186 AW366077 BF569251 
    AW366069 AA233683 BI025035 AW366031 AW376291 BE002924 AW352424 AW366062 
    AW362200 BQ950509 BQ348078 BQ711130 BG035159 CA421050 BG122966 BF816623 
    AW366035 BQ316495 BI025040 BG281888 BG676886 BF872910 BF734156 BI036355 
    BF813258 W39544 BQ348080 CA314996 BF847955 BG755493 BF828669 BF817980 
    BG990660 BG014708 AW352427 BE841868 AW994571 BF909598 BE720161 BF229174 
    AW352423 BG992400 BF854651 AW375166 BF154861 BE927852 BG118824 BG002111 
    AW751814 BP354139 BF081549 BI094414 BE838564 CF121699 AW392751 BF899541 
    AW375203 CD698796 BF734046 BQ299878 BF132101 AW375205 BQ315806 BI053756 
    BE764585 BX414578 BF881775 CA393403 BE812351 BF903305 BQ336001 T69983 
    BF816068 BE076442 AW366070 BM908491 CD614940 BF900319 BF974632 AW366014 
    AW516877 AI887432 BE938713 AW815537 BF851136 AA356754 BM802769 BE007978 
    AW375157 BG479683 BF853229 BF857741 AW375172 BF996336 BE938711 BE698748 
    AA039905 BQ318535 AI924365 BF905585 AW375174 AA233571 BQ355318 AW664433 
    AW366072 AI347853 BE939811 BG223344 C21324 T82881 BE940104 BF816696 
    AW068486 BG953113 AW366033 BF803353 BF817743 H84427 BQ649050 AW375177 
    BG993249 BF892959 CD299553 BE764597 BF905584 BF316777 BE391810 BG874458 
    CF786057 CD614930 BF740420 BF813329 BF762965 AA551786 BM043493 BE812260 
    AW365149 BF374387 AI587093 BG684730 BG762716 BF823648 BF823652 BE159594 
    BF737555 BE812444 AA505503 R69304 BE818810 AA873764 BF819388 BF084373 
    BF841764 BI053466 BF081893 BQ344985 CD614934 BG775918 AW362173 BE940089 
    BF154854 BE812431 BE562396 AW751820 AW375199 R87126 BF798387 BF935335 
    BQ332942 BF349266 N44606 BE762631 AW005380 BI493792 BF349249 BM914381 
    BE004061 BI023347 BI028089 BI024510 BF819381 BG387550 BE925572 AW366016 
    AW748222 AW375064 AW192280 BG117337 BF933049 CD614933 BF968848 BM016817 
    BF742921 BF816692 BE938715 BF806803 AA352414 T57882 BQ940411 BE870194 
    BE278658 BF675848 BG338788 BE159641 BF898191 BF317463 AJ713447 AW994572 
    BE812162 H12952 BF815291 BF751826 AW439167 AW176073 BG951971 BX389549 
    BF905332 BI001241 BI017987 BQ953282 BF839521 BE542241 BE844157 R87125 
    AA716332 BG391644 AW168196 BF081824 BF229893 T23792 AW341858 BF734258 
    BG122147 BQ956874 BI039838 BQ318522 BG120225 BE774341 BF765226 BF761207 
    AI064739 BF822359 BF904792 BQ335758 AW365155 BI055481 AA912349 BG252720 
    BE814099 BM849411 AI907225 BF904426 BE876303 BF912451 BG979502 BE812227 
    AU185216 BX389548 BE073285 BF798437 AA742806 AW365152 BI039121 BF734146 
    BF876337 AW839727 BF332773 AI906010 BE927886 BG680128 BQ308014 CF121851 
    BF801008 BE716482 AW806643 AA366081 AA622309 AW392726 BF851117 AW751854 
    AA856971 BE925590 AI359203 BE178942 AA070528 BF798419 BE819272 BQ316506 
    BF733725 BE812434 BQ362520 AW389970 BG337834 AI803834 BG119780 BM475782 
    BI871247 BG821787 BF900251 R35719 BF742934 BI038927 BE817145 H27166 
    BF757759 BQ328150 AI910209 BG993230 BF081435 BF849720 AA659767 BG420941 
    AW581219 BQ433505 BE178938 BI029528 CD614936 BF304658 BM455520 BG015296 
    BI193300 BF819546 BE004005 BE763221 BG250400 BQ326378 BQ316509 BG035824 
    BM014676 BG996897 BQ722818 H45734 BF932483 BG387332 BX336220 AW375187 
    BF816699 AW375173 BI085876 BQ882822 AW389952 BG741886 BE903006 BQ316507 
    BF800057 BF094758 AW375202 BE812109 AI686345 BF815286 AW751869 BG319555 
    BG003341 BM019205 BE894236 BG251913 BU535491 BF819413 AW751871 BG949897 
    R61628 BM013236 BG990929 BG621233 BF756528 AW375208 BE816429 BF734015 
    BP334970 BE185047 BQ347396 BU536143 BQ344952 BQ316494 AA527129 AW375167 
    BG994264 BU185963 BG621113 BQ305510 BE816399 CD614941 BF375175 BQ896768 
    BP364522 BF817015 AW366071 BF326390 BE925462 AW375207 BF081807 T27634 
    CB106998 AW375180 BF847875 BF905581 BF850095 AA402670 BG954716 BM477978 
    BQ327445 AA852678 BG251727 BF800361 BE122676 BF902769 BI012833 BQ669686 
    BE178934 BI006957 BI055460 BF326160 BF734292 BI055461 BE767273 R34219 
    AI910066 BE925609 BF081842 BE166621 AW370770 BE937979 BQ318529 BG988822 
    BF903779 BE819577 BE819478 BE242295 AW375195 BI014742 BG261242 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MYH9 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^
    SP1:                                                  -                             -                                                                           
    SP2:              -                                   -                             -                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36a · 36b ^ 37a · 37b ^ 38a · 38b · 38c ^ 39 ^
    SP1:                          -     -     -     -     -     -     -     -     -     -     -     -     -                                                         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                  -     -   
    SP5:                                                                                                                                                            

    ExUns: 40a · 40b · 40c ^ 41a · 41b ^ 42a · 42b ^ 43 ^ 44a · 44b ^ 45a · 45b · 45c ^ 46a · 46b
    SP1:  -                                                                                       
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:  -     -     -     -                                                                     
    SP5:  -           -     -     -     -                                                         


    ECgene alternative splicing isoforms for MYH9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MYH9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTAAAAAA
    MYH9 Expression
    About this image


    MYH9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    MYH9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYH9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.474751

    UniProtKB/Swiss-Prot: MYH9_HUMAN, P35579
    Tissue specificity: In the kidney, expressed in the glomeruli. Also expressed in leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MYH9: 
              Cell Surface Markers in human mouse rat
              Cell Motility in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MYH9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYH9
    QuantiTect SYBR Green Assays in human, mouse, rat MYH9
    QuantiFast Probe-based Assays in human, mouse, rat MYH9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYH9 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myh91 , 5 myosin, heavy polypeptide 9, non-muscle1, 5 90.51(n)1
    97.09(a)1
      15 (36.81 cM)5
    178861  NM_022410.31  NP_071855.21 
     777605875 
    chicken
    (Gallus gallus)
    Aves MYH91 myosin, heavy chain 9, non-muscle 80.91(n)
    92.75(a)
      396469  NM_205477.1  NP_990808.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYH96
    myosin, heavy chain 9, non-muscle
    92(a)
    1 ↔ 1
    5(22047775-22130391)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF055895.12   -- 76.39(n)    AF055895.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045324.12   -- 77.88(n)   393797  BC045324.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta zip3 NOT muscle attachment myosin ATPase 61(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea nmy-13 myosin 50(a)
    (best of 6)
      X(2944856-2952845)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MYO16
    Type II myosin heavy chain, required for wild-type...
    29(a)
    1 → many
    VIII(151666-157452) YHR023W


    ENSEMBL Gene Tree for MYH9 (if available)
    TreeFam Gene Tree for MYH9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYH9 gene
    MYH82  MYH12  MYH22  MYH112  MYH142  MYH102  MYH132  MYH7B2  
    MYH42  MYH32  MYH152  MYH62  MYH72  
    Selected SIMAP similar genes for MYH9 using alignment to 5 protein entries:     MYH9_HUMAN (see all proteins) (see all similar genes):
    FLJ00279    DKFZp686D10126    MYH11    MYH10    MYH14    MYO1C
    MYO1E    MYH7    MYO3B    MYO9B    MYO9B variant protein    MYO15A
    MYO9A    MYH6    MYH2    MYH13    MYH7B    MYO1G

    Find genes that share paralogs with MYH9           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MYH9
    PGOHUM00000263186


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYH9 (see all 2780)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0183164
    Sebastian syndrome (SBS)4--see VAR_0183162 D N mis40--------
    VAR_0183104
    Sebastian syndrome (SBS)4--see VAR_0183102 K N mis40--------
    VAR_0107944
    May-Hegglin anomaly (MHA)4--see VAR_0107942 T I mis40--------
    VAR_0107934
    Deafness, autosomal dominant, 17 (DFNA17)4--see VAR_0107932 R H mis40--------
    VAR_0442264
    Fechtner syndrome (FTNS)4--see VAR_0442262 K Q mis40--------
    VAR_0183174
    May-Hegglin anomaly (MHA)4--see VAR_0183172 D Y mis40--------
    VAR_0107964
    May-Hegglin anomaly (MHA)4--see VAR_0107962 D H mis40--------
    VAR_0360064
    A breast cancer sample4--see VAR_0360062 K N mis40--------
    VAR_0107974
    Sebastian syndrome (SBS)4--see VAR_0107972 E K mis40--------
    VAR_0183114
    Epstein syndrome (EPS)4--see VAR_0183112 R H mis40--------

    HapMap Linkage Disequilibrium report for MYH9 (36677323 - 36784063 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MYH9 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724192CNV Deletion23290073
    esv2724191CNV Deletion23290073
    esv2665599CNV Deletion23128226
    esv1147593CNV Insertion17803354
    nsv915007CNV Loss21882294
    nsv834186CNV Loss17160897
    nsv523911CNV Loss19592680
    nsv834185CNV Loss17160897
    nsv523629CNV Loss19592680
    nsv522931CNV Gain19592680

    Human Gene Mutation Database (HGMD): MYH9
    Locus Specific Mutation Databases (LSDB): MYH9

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYH9
    DNA2.0 Custom Variant and Variant Library Synthesis for MYH9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 160775   
    OMIM disorders: 155100  153640  605249  603622  153650  600208  
    UniProtKB/Swiss-Prot: MYH9_HUMAN, P35579
  • May-Hegglin anomaly (MHA) [MIM:155100]: A disorder characterized by thrombocytopenia, giant platelets and
    Dohle body-like inclusions in peripheral blood leukocytes. appearing as highly parallel paracrystalline bodies.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Sebastian syndrome (SBS) [MIM:605249]: Autosomal dominant macrothrombocytopenia characterized by
    thrombocytopenia, giant platelets and leukocyte inclusions that are smaller and less organized than in
    May-Hegglin anomaly. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Fechtner syndrome (FTNS) [MIM:153640]: Autosomal dominant macrothrombocytopenia characterized by
    thrombocytopenia, giant platelets and leukocyte inclusions that are small and poorly organized. Additionally,
    FTNS is distinguished by Alport-like clinical features of sensorineural deafness, cataracts and nephritis.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Alport syndrome, with macrothrombocytopenia (APSM) [MIM:153650]: An autosomal dominant disorder
    characterized by the association of ocular lesions, sensorineural hearing loss and nephritis (Alport syndrome)
    with platelet defects. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Epstein syndrome (EPS) [MIM:153650]: An autosomal dominant disorder characterized by the association of
    macrothrombocytopathy, sensorineural hearing loss and nephritis. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Deafness, autosomal dominant, 17 (DFNA17) [MIM:603622]: A form of deafness characterized by progressive
    high frequency hearing impairment and cochleosaccular degeneration. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Macrothrombocytopenia and progressive sensorineural deafness (MPSD) [MIM:600208]: An autosomal dominant
    disorder characterized by the association of macrothrombocytopathy and progressive sensorineural hearing loss
    without renal dysfunction. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Note=Subjects with mutations in the motor domain of MYH9 present with severe thrombocytopenia and develop
    nephritis and deafness before the age of 40 years, while those with mutations in the tail domain have a much
    lower risk of noncongenital complications and significantly higher platelet counts. The clinical course of
    patients with mutations in the four most frequently affected residues of MYH9 (responsible for 70% of
    MYH9-related cases) were evaluated. Mutations at residue 1933 do not induce kidney damage or cataracts and cause
    deafness only in the elderly, those in position 702 result in severe thrombocytopenia and produce nephritis and
    deafness at a juvenile age, while alterations at residue 1424 or 1841 result in intermediate clinical pictures
  • Note=Genetic variations in MYH9 are associated with non-diabetic end stage renal disease (ESRD)

  • 13 diseases for MYH9:    
    About MalaCards
    myh9-related disorders    myh9 related thrombocytopenia    deafness, autosomal dominant 17    macrothrombocytopenia and progressive sensorineural deafness
    dfna17 nonsyndromic hearing loss and deafness    mitochondrial complex v deficiency, mitochondrial 2    autosomal dominant alport syndrome    nonsyndromic hearing loss and deafness
    nonsyndromic hearing loss and deafness, mitochondrial    alport syndrome    mitochondrial complex v deficiency    bernard-soulier syndrome
    deafness, autosomal dominant 4b

    5 diseases from the University of Copenhagen DISEASES database for MYH9:
    Thrombocytopenia     Sensorineural hearing loss     Bernard-Soulier syndrome     Kidney disease
    Alport syndrome

    Find genes that share disorders with MYH9           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MYH9 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    may-hegglin anomaly 97.7 30 12930685 (2), 19954613 (1), 11935325 (1), 11943476 (1) (see all 18)
    sebastian syndrome 96.9 6 11935325 (1), 19408192 (1), 10973259 (1), 11159552 (1) (see all 5)
    epsteins syndrome 96.5 11 11943476 (2), 11935325 (1), 17975807 (1), 19408192 (1) (see all 9)
    fechtner syndrome 96.3 8 11752022 (2), 17655694 (2), 18718080 (1), 19408192 (1)
    platelet disorder 82.7 5 11935325 (2), 19645626 (1), 16044442 (1)
    deafness sensorineural 75.6 3 19967157 (1), 10973259 (1), 17655694 (1)
    bernard-soulier syndrome 74.8 4 15477207 (1), 14706930 (1), 14635206 (1), 15529446 (1)
    alports syndrome 73.9 2 12454218 (1), 11590545 (1)
    nephritis 72.1 6 17975807 (1), 19967157 (1), 16978745 (1), 19645626 (1) (see all 6)
    thrombocytopenia 69.7 18 15667538 (1), 15869600 (1), 17241369 (1), 19046415 (1) (see all 12)

    GeneTests: MYH9
    GeneReviews: MYH9
    Genetic Association Database (GAD): MYH9
    Human Genome Epidemiology (HuGE) Navigator: MYH9 (21 documents)

    Export disorders for MYH9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYH9 gene, integrated from 10 sources (see all 342):
    (articles sorted by number of sources associating them with MYH9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans. (PubMed id 19177153)1, 2, 4, 9 Freedman B.I....Bowden D.W. (Kidney Int. 2009)
    2. Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9. (PubMed id 11023810)1, 2, 3, 9 Lalwani A.K....Mhatre A.N. (Am. J. Hum. Genet. 2000)
    3. MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. (PubMed id 18794856)1, 2, 4, 9 Kopp J.B.... Winkler C.A. (Nat. Genet. 2008)
    4. Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes. (PubMed id 1860190)1, 2, 3, 9 Simons M.... Weir L. (Circ. Res. 1991)
    5. Immunofluorescence analysis of neutrophil nonmuscle myosin heavy chain-A in MYH9 disorders: association of subcellular localization with MYH9 mutations. (PubMed id 12533692)1, 2, 9 Kunishima S.... Saito H. (Lab. Invest. 2003)
    6. Expression of the nonmuscle myosin heavy chain IIA in the human kidney and screening for MYH9 mutations in Epstein and Fechtner syndromes. (PubMed id 11752022)1, 2, 9 Arrondel C.... Heidet L. (J. Am. Soc. Nephrol. 2002)
    7. Nonmuscle myosin heavy chain IIA mutations define a spectrum of autosomal dominant macrothrombocytopenias: May-Hegglin anomaly and Fechtner, Sebastian, Epstein, and Alport-like syndromes. (PubMed id 11590545)1, 2, 9 Heath K.E....Martignetti J.A. (Am. J. Hum. Genet. 2001)
    8. Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related disease. (PubMed id 18059020)1, 2, 9 Pecci A.... Savoia A. (Hum. Mutat. 2008)
    9. Macrothrombocytopenia and progressive deafness is due to a mutation in MYH9. (PubMed id 12621333)1, 2, 9 Mhatre A.N.... Lalwani A.K. (Otol. Neurotol. 2003)
    10. The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family Study. (PubMed id 19921264)1, 4, 9 Franceschini N....Cole S.A. (Hum. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4627 HGNC: 7579 AceView: MYH9 Ensembl:ENSG00000100345 euGenes: HUgn4627
    ECgene: MYH9 Kegg: 4627 H-InvDB: MYH9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYH9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYH9 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=MYH9[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYH9 gene:
    Search GeneIP for patents involving MYH9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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