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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYH9 Gene

protein-coding   GIFtS: 72
GCID: GC22M036677

Myosin, Heavy Chain 9, Non-Muscle

(Previous names: myosin, heavy polypeptide 9, non-muscle)
(Previous symbol: DFNA17)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Myosin, Heavy Chain 9, Non-Muscle1 2     MHA2 5
DFNA171 2 5     Myosin, Heavy Polypeptide 9, Non-Muscle1
Nonmuscle Myosin Heavy Chain II-A1 2     BDPLT62
Cellular Myosin Heavy Chain, Type A2 3     EPSTS2
Myosin Heavy Chain 92 3     NMHC-II-A2
Myosin Heavy Chain, Non-Muscle IIa2 3     NMMHCA2
Non-Muscle Myosin Heavy Chain A2 3     myosin-92
Non-Muscle Myosin Heavy Chain IIa2 3     Non-Muscle Myosin Heavy Polypeptide 92
NMMHC-IIA2 3     NMMHC-A3
FTNS2 5     NMMHC II-A3

External Ids:    HGNC: 75791   Entrez Gene: 46272   Ensembl: ENSG000001003457   OMIM: 1607755   UniProtKB: P355793   

Export aliases for MYH9 gene to outside databases

Previous GC identifers: GC22M033322 GC22M034949 GC22M035001 GC22M019645


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYH9 Gene:
This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional
myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and
a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility
and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural
deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian
syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. (provided by
RefSeq, Dec 2011)

GeneCards Summary for MYH9 Gene: 
MYH9 (myosin, heavy chain 9, non-muscle) is a protein-coding gene. Diseases associated with MYH9 include sebastian syndrome, and myh9-related disorders, and among its related super-pathways are Immune response CCR3 signaling in eosinophils and Antioxidant Action of Vitamin-C. GO annotations related to this gene include calmodulin binding and protein homodimerization activity. An important paralog of this gene is MYH8.

UniProtKB/Swiss-Prot: MYH9_HUMAN, P35579
Function: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such
as secretion and capping

summary for MYH9 Gene:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYH9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYH9 gene promoter:
         Max1   USF1   MyoD   Tal-1beta   E47   c-Ets-1   USF-1   Cart-1   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MYH9 promoter sequence
   Search SABiosciences Chromatin IP Primers for MYH9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYH9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q13.1

MYH9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYH9 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M036677:  view genomic region     (about GC identifiers)

Start:
36,677,323 bp from pter      End:
36,784,063 bp from pter
Size:
106,741 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MYH9_HUMAN, P35579 (See protein sequence)
Recommended Name: Myosin-9  
Size: 1960 amino acids; 226532 Da
Subunit: Interacts with PDLIM2 (By similarity). Interacts with SLC6A4 (By similarity). Myosin is a hexameric
protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light
chain subunits (MLC-2). Interacts with RASIP1. Interacts with DDR1 (By similarity). Interacts with SVIL and HTRA3
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cell cortex (By similarity).
Note=Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells (By
similarity)
Sequence caution: Sequence=CAD89954.1; Type=Frameshift; Positions=1890;
3 PDB 3D structures from and Proteopedia for MYH9:
2LNK (3D)        3ZWH (3D)        4ETO (3D)    
Secondary accessions: O60805 Q86T83
Alternative splicing: 2 isoforms:  P35579-1   P35579-2   

Explore the universe of human proteins at neXtProt for MYH9: NX_P35579

Explore proteomics data for MYH9 at MOPED 

Post-translational modifications:

  • UniProtKB: ISGylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P35579

  • MYH9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MYH9 Protein Expression
    REFSEQ proteins: NP_002464.1  
    ENSEMBL proteins: 
     ENSP00000216181   ENSP00000384631   ENSP00000414852  
    Reactome Protein details: P35579
    Human Recombinant Protein Products for MYH9: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MYH9
    GenScript Custom Purified and Recombinant Proteins Services for MYH9
    Novus Biologicals MYH9 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYH9 

    Gene Ontology (GO): 5/23 cellular component terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IDA14508515
    GO:0001726ruffle IDA16403913
    GO:0001772colocalizes with immunological synapse IDA15064761
    GO:0001931uropod IDA15064761
    GO:0005634nucleus IDA14508515

    MYH9 for ontologies           About GeneDecksing



    MYH9 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MYH9
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    Cell Signaling Technology (CST) Antibodies for MYH9 
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    Abcam antibodies for MYH9
    Cloud-Clone Corp. Antibodies for MYH9 
    ThermoFisher Antibody for MYH9
    LSBio Antibodies in human, mouse, rat for MYH9 

    Assay Products for MYH9: 
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    GenScript Custom Assay Services for MYH9
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MYH9 
    Cloud-Clone Corp. CLIAs for MYH9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MYHII: Myosins / Myosin superfamily : Class II

    5/7 InterPro protein domains (see all 7):
     IPR027401 Myosin-like_IQ_dom
     IPR004009 Myosin_N
     IPR027417 P-loop_NTPase
     IPR000048 IQ_motif_EF-hand-BS
     IPR002928 Myosin_tail

    Graphical View of Domain Structure for InterPro Entry P35579

    ProtoNet protein and cluster: P35579

    4 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB002017 Spectrin repeat
    IPB002928 Myosin tail
    IPB004009 Myosin N-terminal SH3-like domain


    UniProtKB/Swiss-Prot: MYH9_HUMAN, P35579
    Domain: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of
    4 heptapeptides, characteristic for alpha-helical coiled coils
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 myosin head-like domain


    MYH9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYH9_HUMAN, P35579
    Function: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such
    as secretion and capping

         Genatlas biochemistry entry for MYH9:
    myosin,motor contractile protein moving towards the "plus" end of actin track,heavy polypeptide 9,non muscle

         Gene Ontology (GO): 5/15 molecular function terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000146microfilament motor activity IDA12237319
    GO:0000166nucleotide binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003774motor activity NAS12421915
    GO:0003779actin binding IDA15065866
         
    MYH9 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MYH9:
     Increased focal adhesion (FA)   Large cells 

         13 MGI mutant phenotypes (inferred from 15 alleles(MGI details for Myh9):
     cardiovascular system  cellular  embryogenesis  growth/size  hearing/vestibular/ear 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  nervous system 
     normal  renal/urinary system  vision/eye 

    MYH9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MYH9: Myh9tm1.2Gac Myh9tm1Maco

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MYH9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MYH9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYH9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYH9 

    miRNA
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    miRTarBase miRNAs that target MYH9:
    hsa-mir-124 (MIRT002579)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYH9
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate MYH9 (see all 47):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-300 hsa-miR-376b hsa-miR-25 hsa-miR-449a hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidMYH9 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MYH9
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    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: MYH9 (NM_002473)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYH9

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MYH9 About   (see all 19)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response CCR3 signaling in eosinophils
    Immune response CCR3 signaling in eosinophils0.51
    Inhibitory action of Lipoxins on neutrophil migration0.51
    2PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    3Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin-mediated cell adhesion and migration0.49
    Cell adhesion Tight junctions0.33
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    4Sema4D in semaphorin signaling
    Sema4D in semaphorin signaling0.89
    Semaphorin interactions0.41
    Sema4D induced cell migration and growth-cone collapse0.89
    5Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.80
    Fcgamma receptor (FCGR) dependent phagocytosis0.80

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for MYH9
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils
    Development MAG-dependent inhibition of neurite outgrowth

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYH9 (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions

    1 Cell Signaling Technology (CST) Pathway for MYH9
        Cytoskeletal Signaling

    5/6 GeneGo (Thomson Reuters) Pathways for MYH9 (see all 6)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Tight junctions

    5/9        Reactome Pathways for MYH9 (see all 9)
        Developmental Biology
    Fcgamma receptor (FCGR) dependent phagocytosis
    Semaphorin interactions
    Sema4D induced cell migration and growth-cone collapse
    Regulation of actin dynamics for phagocytic cup formation


    4         Kegg Pathways  (Kegg details for MYH9):
        Tight junction
    Regulation of actin cytoskeleton
    Salmonella infection
    Viral myocarditis


    MYH9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MYH9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/991 Interacting proteins for MYH9 (P355791, 2, 3 ENSP000002161814) via UniProtKB, MINT, STRING, and/or I2D (see all 991)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCLP193381, 2, 3, ENSP000003181954EBI-350338,EBI-346967 MINT-7945693 I2D: score=2 STRING: ENSP00000318195
    ACTBP607092, 3, ENSP000003499604MINT-7945693 MINT-7899812 MINT-7900157 MINT-7947479 I2D: score=4 STRING: ENSP00000349960
    HSP90AB1P082382, 3MINT-7945693 MINT-72662 MINT-7947479 I2D: score=3 
    CALM1P621582, 3MINT-7899812 I2D: score=1 
    CALM2P621582, 3MINT-7899812 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000212meiotic spindle organization IEA--
    GO:0000904cell morphogenesis involved in differentiation ----
    GO:0000910cytokinesis IMP15774463
    GO:0001525angiogenesis IDA16403913
    GO:0001701in utero embryonic development IEA--

    MYH9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MYH9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MYH9 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BTSSelective inhibitor of skeletal muscle myosin II ATPase activity[1576-37-0]
    (R)-(+)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)[1177356-70-5]
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)[856925-71-8]
    (+-)-BlebbistatinSelective inhibitor of myosin II ATPase activity[674289-55-5]

    4 Novoseek inferred chemical compound relationships for MYH9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phorbol 21.5 1 15496418 (1)
    calcium 0 1 18312684 (1)
    threonine 0 1 10945986 (1)
    tyrosine 0 1 19401332 (1)

    Search CenterWatch for drugs/clinical trials and news about MYH9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYH9 gene: 
    NM_002473.4  

    Unigene Cluster for MYH9:

    Myosin, heavy chain 9, non-muscle
    Hs.474751  [show with all ESTs]
    Unigene Representative Sequence: NM_002473
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216181(uc003apg.3 uc003aph.1) ENST00000475726 ENST00000486218
    ENST00000459960 ENST00000495928 ENST00000473022 ENST00000477189 ENST00000472210
    ENST00000463027 ENST00000401701(uc003api.1) ENST00000456729
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate MYH9 (see all 47):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-300 hsa-miR-376b hsa-miR-25 hsa-miR-449a hsa-miR-10b*
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYH9

    Additional mRNA sequence: 

    AB191263.1 AB290175.1 AK025219.1 AK025393.1 AK131080.1 AK291609.1 AK304840.1 BC011915.2 
    BC049849.1 BC090921.1 BC111387.1 BC113067.1 BC131741.1 CR456526.1 D11393.1 HQ326701.1 
    L29141.1 M31013.1 M69180.1 M81105.1 

    24/58 DOTS entries (see all 58):

    DT.95126859  DT.119239  DT.92464957  DT.95347813  DT.97761844  DT.100659644  DT.100659636  DT.100659653 
    DT.91985714  DT.120655569  DT.95347783  DT.120655540  DT.100659655  DT.120655825  DT.120655658  DT.100659642 
    DT.120655748  DT.120655676  DT.91811745  DT.100659641  DT.102840742  DT.95347683  DT.97867641  DT.120655554 

    24/1191 AceView cDNA sequences (see all 1191):

    BQ688338 BU632240 AW192058 BM454409 CA442197 BU625874 AI539529 AW511726 
    BQ707568 BQ641343 AA856897 AW511520 CA430467 BU622803 BE795516 H55296 
    BG325739 AW004952 CF995724 BE311756 BI028048 CN484067 BQ920939 AW583843 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for MYH9 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^
    SP1:                                                  -                             -                                                                           
    SP2:              -                                   -                             -                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36a · 36b ^ 37a · 37b ^ 38a · 38b · 38c ^ 39 ^
    SP1:                          -     -     -     -     -     -     -     -     -     -     -     -     -                                                         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                  -     -   
    SP5:                                                                                                                                                            

    ExUns: 40a · 40b · 40c ^ 41a · 41b ^ 42a · 42b ^ 43 ^ 44a · 44b ^ 45a · 45b · 45c ^ 46a · 46b
    SP1:  -                                                                                       
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:  -     -     -     -                                                                     
    SP5:  -           -     -     -     -                                                         


    ECgene alternative splicing isoforms for MYH9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYH9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTAAAAAA
    MYH9 Expression
    About this image


    See MYH9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYH9

    SOURCE GeneReport for Unigene cluster: Hs.474751

    UniProtKB/Swiss-Prot: MYH9_HUMAN, P35579
    Tissue specificity: In the kidney, expressed in the glomeruli. Also expressed in leukocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including MYH9: 
              Cell Surface Markers in human mouse rat
              Cell Motility in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MYH9
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MYH9
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYH9
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYH9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYH9 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myh91 , 5 myosin, heavy polypeptide 9, non-muscle1, 5 90.51(n)1
    97.09(a)1
      15 (36.81 cM)5
    178861  NM_022410.21  NP_071855.21 
     777605875 
    chicken
    (Gallus gallus)
    Aves MYH91 myosin, heavy chain 9, non-muscle 80.91(n)
    92.75(a)
      396469  NM_205477.1  NP_990808.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYH96
    Uncharacterized protein
    92(a)
    1 ↔ 1
    5(22047775-22130391)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF055895.12   -- 76.39(n)    AF055895.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045324.12   -- 77.88(n)   393797  BC045324.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta zip3 NOT muscle attachment myosin ATPase 61(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea nmy-13 myosin 50(a)
    (best of 6)
      X(2944856-2952845)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MYO16
    Type II myosin heavy chain, required for wild-type...
    29(a)
    1 → many
    VIII(151666-157452)


    ENSEMBL Gene Tree for MYH9 (if available)
    TreeFam Gene Tree for MYH9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYH9 gene
    MYH82  MYH12  MYH22  MYH112  MYH142  MYH102  MYH132  MYH7B2  
    MYH42  MYH32  MYH152  MYH62  MYH72  
    18/40 SIMAP similar genes for MYH9 using alignment to 6 protein entries:     MYH9_HUMAN (see all proteins) (see all similar genes):
    FLJ00279    DKFZp686D10126    MYH11    MYH10    MYH14    MYO1C
    MYO1E    MYO3B    MYO9B    MYO9B variant protein    MYH7    MYO15A
    MYO9A    MYH6    MYO1H    MYH13    MYH2    MYO1G

    MYH9 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MYH9
    PGOHUM00000263186


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2780 SNPs in MYH9 are shown (see all 2780)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0183164
    Sebastian syndrome (SBS)4--see VAR_0183162 D N mis40--------
    VAR_0183104
    Sebastian syndrome (SBS)4--see VAR_0183102 K N mis40--------
    VAR_0107944
    May-Hegglin anomaly (MHA)4--see VAR_0107942 T I mis40--------
    VAR_0107934
    Deafness, autosomal dominant, 17 (DFNA17)4--see VAR_0107932 R H mis40--------
    VAR_0442264
    Fechtner syndrome (FTNS)4--see VAR_0442262 K Q mis40--------
    VAR_0183174
    May-Hegglin anomaly (MHA)4--see VAR_0183172 D Y mis40--------
    VAR_0107964
    May-Hegglin anomaly (MHA)4--see VAR_0107962 D H mis40--------
    VAR_0360064
    A breast cancer sample4--see VAR_0360062 K N mis40--------
    VAR_0107974
    Sebastian syndrome (SBS)4--see VAR_0107972 E K mis40--------
    VAR_0183114
    Epstein syndrome (EPS)4--see VAR_0183112 R H mis40--------

    HapMap Linkage Disequilibrium report for MYH9 (36677323 - 36784063 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for MYH9 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2724192CNV Deletion23290073
    esv2724191CNV Deletion23290073
    esv2665599CNV Deletion23128226
    esv1147593CNV Insertion17803354
    nsv915007CNV Loss21882294
    nsv834186CNV Loss17160897
    nsv523911CNV Loss19592680
    nsv834185CNV Loss17160897
    nsv523629CNV Loss19592680
    nsv522931CNV Gain19592680


    Human Gene Mutation Database (HGMD): MYH9

    Locus Specific Mutation Databases (LSDB): MYH9
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MYH9
    DNA2.0 Custom Variant and Variant Library Synthesis for MYH9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 160775   
    OMIM disorders: 155100  153640  605249  603622  153650  600208  
    UniProtKB/Swiss-Prot: MYH9_HUMAN, P35579
  • May-Hegglin anomaly (MHA) [MIM:155100]: A disorder characterized by thrombocytopenia, giant platelets and
    Dohle body-like inclusions in peripheral blood leukocytes. appearing as highly parallel paracrystalline bodies.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Sebastian syndrome (SBS) [MIM:605249]: Autosomal dominant macrothrombocytopenia characterized by
    thrombocytopenia, giant platelets and leukocyte inclusions that are smaller and less organized than in
    May-Hegglin anomaly. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Fechtner syndrome (FTNS) [MIM:153640]: Autosomal dominant macrothrombocytopenia characterized by
    thrombocytopenia, giant platelets and leukocyte inclusions that are small and poorly organized. Additionally,
    FTNS is distinguished by Alport-like clinical features of sensorineural deafness, cataracts and nephritis.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Alport syndrome, with macrothrombocytopenia (APSM) [MIM:153650]: An autosomal dominant disorder
    characterized by the association of ocular lesions, sensorineural hearing loss and nephritis (Alport syndrome)
    with platelet defects. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Epstein syndrome (EPS) [MIM:153650]: An autosomal dominant disorder characterized by the association of
    macrothrombocytopathy, sensorineural hearing loss and nephritis. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Deafness, autosomal dominant, 17 (DFNA17) [MIM:603622]: A form of deafness characterized by progressive
    high frequency hearing impairment and cochleosaccular degeneration. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Macrothrombocytopenia and progressive sensorineural deafness (MPSD) [MIM:600208]: An autosomal dominant
    disorder characterized by the association of macrothrombocytopathy and progressive sensorineural hearing loss
    without renal dysfunction. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Note=Subjects with mutations in the motor domain of MYH9 present with severe thrombocytopenia and develop
    nephritis and deafness before the age of 40 years, while those with mutations in the tail domain have a much
    lower risk of noncongenital complications and significantly higher platelet counts. The clinical course of
    patients with mutations in the four most frequently affected residues of MYH9 (responsible for 70% of
    MYH9-related cases) were evaluated. Mutations at residue 1933 do not induce kidney damage or cataracts and cause
    deafness only in the elderly, those in position 702 result in severe thrombocytopenia and produce nephritis and
    deafness at a juvenile age, while alterations at residue 1424 or 1841 result in intermediate clinical pictures
  • Note=Genetic variations in MYH9 are associated with non-diabetic end stage renal disease (ESRD)

  • 20/59 diseases for MYH9 (see all 59):    About MalaCards
    sebastian syndrome    myh9-related disorders    macrothrombocytopenia progressive deafness    deafness, autosomal dominant 17
    macrothrombocytopenia and progressive sensorineural deafness    myh9 related thrombocytopenia    dfna17 nonsyndromic hearing loss and deafness    macrothrombocytopenia
    autosomal dominant alport syndrome    nonsyndromic hearing loss and deafness, autosomal dominant    alport syndrome    bernard-soulier syndrome
    acute graft versus host disease    was-related disorders    graft versus host disease    syphilis
    focal segmental glomerulosclerosis    fasciitis    cleft palate    nephritis

    5 diseases from the University of Copenhagen DISEASES database for MYH9:
    Thrombocytopenia     Sensorineural hearing loss     Bernard-Soulier syndrome     Kidney disease
    Alport syndrome

    MYH9 for disorders           About GeneDecksing

    10/28 Novoseek inferred disease relationships for MYH9 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    may-hegglin anomaly 97.7 30 12930685 (2), 19954613 (1), 11935325 (1), 11943476 (1) (see all 18)
    sebastian syndrome 96.9 6 11935325 (1), 19408192 (1), 10973259 (1), 11159552 (1) (see all 5)
    epsteins syndrome 96.5 11 11943476 (2), 11935325 (1), 17975807 (1), 19408192 (1) (see all 9)
    fechtner syndrome 96.3 8 11752022 (2), 17655694 (2), 18718080 (1), 19408192 (1)
    platelet disorder 82.7 5 11935325 (2), 19645626 (1), 16044442 (1)
    deafness sensorineural 75.6 3 19967157 (1), 10973259 (1), 17655694 (1)
    bernard-soulier syndrome 74.8 4 15477207 (1), 14706930 (1), 14635206 (1), 15529446 (1)
    alports syndrome 73.9 2 12454218 (1), 11590545 (1)
    nephritis 72.1 6 17975807 (1), 19967157 (1), 16978745 (1), 19645626 (1) (see all 6)
    thrombocytopenia 69.7 18 15667538 (1), 15869600 (1), 17241369 (1), 19046415 (1) (see all 12)

    GeneTests: MYH9
    GeneReviews: MYH9
    Genetic Association Database (GAD): MYH9
    Human Genome Epidemiology (HuGE) Navigator: MYH9 (21 documents)

    Export disorders for MYH9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYH9 gene, integrated from 9 sources (see all 328) (see top 10):
    (articles sorted by number of sources associating them with MYH9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans. (PubMed id 19177153)1, 2, 4, 9 Freedman B.I....Bowden D.W. (2009)
    2. Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9. (PubMed id 11023810)1, 2, 3, 9 Lalwani A.K....Mhatre A.N. (2000)
    3. MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. (PubMed id 18794856)1, 2, 4, 9 Kopp J.B....Winkler C.A. (2008)
    4. Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes. (PubMed id 1860190)1, 2, 3, 9 Simons M.... Weir L. (1991)
    5. Immunofluorescence analysis of neutrophil nonmuscle myosin heavy chain-A in MYH9 disorders: association of subcellular localization with MYH9 mutations. (PubMed id 12533692)1, 2, 9 Kunishima S.... Saito H. (2003)
    6. Expression of the nonmuscle myosin heavy chain IIA in the human kidney and screening for MYH9 mutations in Epstein and Fechtner syndromes. (PubMed id 11752022)1, 2, 9 Arrondel C.... Heidet L. (2002)
    7. Nonmuscle myosin heavy chain IIA mutations define a spectrum of autosomal dominant macrothrombocytopenias: May-Hegglin anomaly and Fechtner, Sebastian, Epstein, and Alport-like syndromes. (PubMed id 11590545)1, 2, 9 Heath K.E....Martignetti J.A. (2001)
    8. Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related disease. (PubMed id 18059020)1, 2, 9 Pecci A....Savoia A. (2008)
    9. Macrothrombocytopenia and progressive deafness is due to a mutation in MYH9. (PubMed id 12621333)1, 2, 9 Mhatre A.N.... Lalwani A.K. (2003)
    10. The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family Study. (PubMed id 19921264)1, 4, 9 Franceschini N....Cole S.A. (2010)
    11. Mutations in MYH9 exons 1, 16, 26, and 30 are infrequ ently found in Japanese patients with nonsyndromic deafness. (PubMed id 19645626)1, 4, 9 Kunishima S....Saito H. (2009)
    12. Polymorphisms in the Nonmuscle Myosin Heavy Chain 9 Gene (MYH9) Are Associated with Albuminuria in Hypertensive African Americans: The HyperGEN Study. (PubMed id 19153477)1, 4, 9 Freedman B.I....Hunt S.C. (2009)
    13. Further evidence for the involvement of MYH9 in the etiology of non-syndromic cleft lip with or without cleft palate. (PubMed id 19320731)1, 4, 9 Birnbaum S....Mangold E. (2009)
    14. Epstein syndrome: another renal disorder with mutations in the nonmuscle myosin heavy chain 9 gene. (PubMed id 11935325)1, 2, 9 Seri M.... Savoia A. (2002)
    15. Identification of six novel MYH9 mutations and genotype-phenotype relationships in autosomal dominant macrothrombocytopenia with leukocyte inclusions. (PubMed id 11776386)1, 2, 9 Kunishima S....Saito H. (2001)
    16. Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes. (PubMed id 10973259)1, 2, 9 Seri M.... Martignetti J.A. (2000)
    17. Association among polymorphisms at MYH9, environmenta l factors, and nonsyndromic orofacial clefts in western China. (PubMed id 19891592)1, 4, 9 Jia Z.L....Shi B. (2010)
    18. African ancestry allelic variation at the MYH9 gene c ontributes to increased susceptibility to non-diabetic end-stage kidney disease in Hispanic Americans. (PubMed id 20144966)1, 4, 9 Behar D.M....Skorecki K. (2010)
    19. Genomic screening identifies novel linkages and provides further evidence for a role of MYH9 in nonsyndromic cleft lip and palate. (PubMed id 18716610)1, 4, 9 Chiquet B.T....Hecht J.T. (2008)
    20. RASD2, MYH9, and CACNG2 Genes at Chromosome 22q12 Associated with the Subgroup of Schizophrenia with Non-Deficit in Sustained Attention and Executive Function. (PubMed id 18571626)1, 4, 9 Liu Y.L....Hwu H.G. (2008)
    21. MYH9-related disease: may-Hegglin anomaly, Sebastian syndrome, Fechtner syndrome, and Epstein syndrome are not distinct entities but represent a variable expression of a single illness. (PubMed id 12792306)1, 2, 9 Seri M.... Savoia A. (2003)
    22. Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May- Hegglin anomaly. (PubMed id 10973260)1, 2, 9 Kelley M.J.... Korczak J.F. (2000)
    23. MYH9 is associated with nondiabetic end-stage renal disease in African Americans. (PubMed id 18794854)1, 2, 9 Kao W.H....Parekh R.S. (2008)
    24. Asp1424Asn MYH9 mutation results in an unstable protein responsible for the phenotypes in May-Hegglin anomaly/Fechtner syndrome. (PubMed id 12649151)1, 2, 9 Deutsch S.... Beris P. (2003)
    25. Application of a diagnostic algorithm for inherited thrombocytopenias to 46 consecutive patients. (PubMed id 15477207)1, 4, 9 Noris P....Balduini C.L. (2004)
    26. Genome-wide association identifies ATOH7 as a major g ene determining human optic disc size. (PubMed id 20395239)1, 4 Macgregor S....Mackey D.A. (2010)
    27. A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9. (PubMed id 20668430)1, 4 Genovese G....Pollak M.R. (2010)
    28. Candidate genes for non-diabetic ESRD in African Amer icans: a genome-wide association study using pooled DNA. (PubMed id 20532800)1, 4 Bostrom M.A....Freedman B.I. (2010)
    29. Failure to find an association between myosin heavy c hain 9, non-muscle (MYH9) and schizophrenia: a three-stage case-control associa tion study. (PubMed id 20188514)1, 4 Amagane H....Someya T. (2010)
    30. Worldwide distribution of the MYH9 kidney disease sus ceptibility alleles and haplotypes: evidence of historical selection in Africa. (PubMed id 20634883)1, 4 Oleksyk T.K....Winkler C.A. (2010)
    31. The non-muscle Myosin heavy chain 9 gene (MYH9) is no t associated with lupus nephritis in African Americans. (PubMed id 20523037)1, 4 Freedman B.I....Kimberly R.P. (2010)
    32. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (2010)
    33. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (2010)
    34. Non-muscle myosin heavy chain 9 gene MYH9 association s in African Americans with clinically diagnosed type 2 diabetes mellitus-assoc iated ESRD. (PubMed id 19567477)1, 4 Freedman B.I....Bowden D.W. (2009)
    35. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    36. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    37. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    38. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    39. Cellular myosin heavy chain in human leukocytes: isolation of 5' cDNA clones, characterization of the protein, chromosomal localization, and upregulation during myeloid differentiation. (PubMed id 1912569)1, 2 Toothaker L.E.... Tenen D.G. (1991)
    40. Human nonmuscle myosin heavy chain mRNA: generation of diversity through alternative polyadenylylation. (PubMed id 1967836)1, 2 Saez C.G.... Leinwand L.A. (1990)
    41. Differential expression of wild-type and mutant NMMHC-IIA polypeptides in blood cells suggests cell-specific regulation mechanisms in MYH9 disorders. (PubMed id 18192507)1, 9 Kunishima S....Saito H. (2008)
    42. Signaling via the angiotensin-converting enzyme results in the phosphorylation of the nonmuscle myosin heavy chain IIA. (PubMed id 16186248)1, 9 Kohlstedt K....Fleming I. (2006)
    43. Pathogenetic mechanisms of hematological abnormalities of patients with MYH9 mutations. (PubMed id 16162639)1, 9 Pecci A....Torti M. (2005)
    44. MYH9-siRNA and MYH9 mutant alleles: expression in cultured cell lines and their effects upon cell structure and function. (PubMed id 18330899)1, 9 Li Y....Lalwani A.K. (2008)
    45. Haematological characteristics of MYH9 disorders due to MYH9 R702 mutations. (PubMed id 17241369)1, 9 Kunishima S....Saito H. (2007)
    46. Heavy chain myosin 9-related disease (MYH9 -RD): neut rophil inclusions of myosin-9 as a pathognomonic sign of the disorder. (PubMed id 20174760)1, 9 Savoia A....Pecci A. (2010)
    47. Analysis of clinical manifestations, mutant gene and encoded protein in two Chinese MYH9-related disease families. (PubMed id 16806139)1, 9 Yi Y....Ma J. (2006)
    48. Genetics of focal segmental glomerulosclerosis and hu man immunodeficiency virus-associated collapsing glomerulopathy: the role of MY H9 genetic variation. (PubMed id 20347641)1, 9 Winkler C.A....Kopp J.B. (2010)
    49. Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO mice. (PubMed id 15555549)1, 9 Matsushita T....Saito H. (2004)
    50. Genetics, clinical and pathological features of glomerulonephritis associated with mutations of nonmuscle myosin IIA (Fechtner syndrome). (PubMed id 12500226)1, 9 Ghiggeri G.M....Balduini C.L. (2003)
    51. Cloning of the murine non-muscle myosin heavy chain IIA gene ortholog of human MYH9 responsible for May-Hegglin, Sebastian, Fechtner, and Epstein syndromes. (PubMed id 11943476)1, 9 D'Apolito M....Savoia A. (2002)
    52. Identification of the first in cis mutations in MYH9 disorder. (PubMed id 19191864)1, 9 Miyajima Y. and Kunishima S. (2009)
    53. High-resolution melting analysis for detection of MYH9 mutations. (PubMed id 18925516)1, 9 Provaznikova D....Rittich S. (2008)
    54. Identification and characterization of the first large deletion of the MYH9 gene associated with MYH9 disorders. (PubMed id 18284620)1, 9 Kunishima S....Saito H. (2008)
    55. Clinical manifestation and molecular genetic characte rization of MYH9 disorders. (PubMed id 19557653)1, 9 Provaznikova D....Rittich S. (2009)
    56. Identification of three in-frame deletion mutations i n MYH9 disorders suggesting an important hot spot for small rearrangements in M YH9 exon 24. (PubMed id 19459928)1, 9 Miyazaki K....Higashihara M. (2009)
    57. [A non-familial May-Hegglin anomaly accompanying with MYH9 gene R1933X mutation and I1626V polymorphism] (PubMed id 19954613)1, 9 Li Y....Fang M.Y. (2009)
    58. In vitro expression and characterization of MYH9 muta nt alleles linked to hereditary hearing loss. (PubMed id 20416459)1, 9 Wei C.C....Mhatre A.N. (2010)
    59. Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration. (PubMed id 18195072)1, 9 Morin N.A....Kim M. (2008)
    60. Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9. (PubMed id 16567366)1, 9 Kadam K.M....Natraj U. (2006)
    61. Expression of non-muscle type myosin heavy polypeptide 9 (MYH9) in mammalian cells. (PubMed id 14706930)1, 9 Takubo T....Hino M. (2003)
    62. Immunocytochemistry for the heavy chain of the non-muscle myosin IIA as a diagnostic tool for MYH9-related disorders. (PubMed id 11918549)1, 9 Pecci A....Balduini C.L. (2002)
    63. Mutations in the NMMHC-A gene cause autosomal dominant macrothrombocytopenia with leukocyte inclusions (May-Hegglin anomaly/Sebastian syndrome). (PubMed id 11159552)1, 9 Kunishima S....Saito H. (2001)
    64. Gene-gene and gene-environment interactions in HIV-as sociated nephropathy: A focus on the MYH9 nephropathy susceptibility gene. (PubMed id 20005488)1, 9 NA_A+ez M....Freedman B.I. (2010)
    65. MYH9 related disease: four novel mutations of the tai l domain of myosin-9 correlating with a mild clinical phenotype. (PubMed id 20002731)1, 9 Pecci A....Savoia A. (2010)
    66. [May-Hegglin anomaly: past and present--novel diagnostic test and new concept of the disease] (PubMed id 19227191)1, 9 Kunishima S. (2009)
    67. MYH9 related disease: a novel missense Ala95Asp mutat ion of the MYH9 gene. (PubMed id 19860543)1, 9 de Rocco D....Savoia A. (2009)
    68. Identification of the first duplication in MYH9-relat ed disease: a hot spot for unequal crossing-over within exon 24 of the MYH9 gen e. (PubMed id 19450438)1, 9 De Rocco D....Savoia A. (2009)
    69. Cleft lip with or without cleft palate: implication of the heavy chain of non-muscle myosin IIA. (PubMed id 17337617)1, 9 Martinelli M....Savoia A. (2007)
    70. Non-muscle myosin heavy chain IIA and IIB interact and co-localize in living cells: relevance for MYH9-related disease. (PubMed id 16596254)1, 9 Marini M....Ravazzolo R. (2006)
    71. A single class II myosin modulates T cell motility and stopping, but not synapse formation. (PubMed id 15064761)1, 9 Jacobelli J....Krummel M.F. (2004)
    72. Defective expression of GPIb/IX/V complex in platelets from patients with May-Hegglin anomaly and Sebastian syndrome. (PubMed id 12217806)1, 9 Di Pumpo M....Balduini C.L. (2002)
    73. The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA. (PubMed id 19401332)1, 9 Huang Y....Vogel W.F. (2009)
    74. Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA. (PubMed id 18812466)1, 9 Chu C.C....Chiorazzi N. (2008)
    75. An MYH9 human disease model in flies: site-directed mutagenesis of the Drosophila non-muscle myosin II results in hypomorphic alleles with dominant character. (PubMed id 17901043)1, 9 Franke J.D....Kiehart D.P. (2007)
    76. Cleavage of nonmuscle myosin heavy chain-A during apoptosis in human Jurkat T cells. (PubMed id 15749830)1, 9 Kato M....Imajoh-Ohmi S. (2005)
    77. Altered cytoskeleton organization in platelets from patients with MYH9-related disease. (PubMed id 15869600)1, 9 Canobbio I....Torti M. (2005)
    78. Non-muscle myosin heavy chain (MYH9): a new partner fused to ALK in anaplastic large cell lymphoma. (PubMed id 12800156)1, 9 Lamant L....Espinos E. (2003)
    79. Menin, a tumor suppressor, associates with nonmuscle myosin II-A heavy chain. (PubMed id 14508515)1, 9 Obungu V.H....Marx S.J. (2003)
    80. Protein complexes involving alpha v beta 3 integrins, nonmuscle myosin heavy chain-A, and focal adhesion kinase from in thrombospondin-treated smooth muscle cells. (PubMed id 10822899)1, 9 Sajid M....Stouffer G.A. (2000)
    81. Megakaryocytes of patients with MYH9-related thromboc ytopenia present an altered proplatelet formation. (PubMed id 19572073)1, 9 Pecci A....Balduini A. (2009)
    82. Myosin IIA is involved in the endocytosis of CXCR4 induced by SDF-1alpha. (PubMed id 17327270)1, 9 Rey M....Sanchez-Madrid F. (2007)
    83. A new feature of the MYH9-related syndrome: chronic tr ansaminase elevation. (PubMed id 22806255)1 Favier R....Martignetti J.A. (2013)
    84. A Proteomics Strategy for the Identification of FAT10- Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (2013)
    85. Association between a MYH9 polymorphism (rs3752462) an d renal function in the Spanish RENASTUR cohort. (PubMed id 23470845)1 Tavira B....Alvarez V. (2013)
    86. Epistatic role of the MYH9/APOL1 region on familial he maturia genes. (PubMed id 23516419)1 Voskarides K....Deltas C. (2013)
    87. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    88. MYH9-related disease: five novel mutations expanding t he spectrum of causative mutations and confirming genotype/phenotype correlation s. (PubMed id 23123319)1 De Rocco D....Pecci A. (2013)
    89. Characterization of molecules binding to the 70K N-ter minal region of fibronectin by IFAST purification coupled with mass spectrometry . (PubMed id 23750785)1 Moussavi-Harami S.F....Beebe D.J. (2013)
    90. Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation i s required for autophagosome creation in autophagy. (PubMed id 23569248)1 Yang Y....Bhalla K.N. (2013)
    91. PRBC-derived plasma induces non-muscle myosin type IIA -mediated neutrophil migration and morphologic change. (PubMed id 23083320)1 Yu C....Chin Y.E. (2013)
    92. A family with Bolzano-type Bernard-Soulier syndrome ca rries a benign A1939T MYH9 mutation. (PubMed id 22372535)1 Sarangi S.N....Chan E.L. (2013)
    93. Clinical, pathological, and genetic analysis of ten pa tients with MYH9-related disease. (PubMed id 23207509)1 Sun X.H....Ruan C.G. (2013)
    94. The P-body component USP52/PAN2 is a novel regulator o f HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (2013)
    95. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. (PubMed id 23084401)1 Singh G....Moore M.J. (2012)
    96. Nonmuscle myosin IIA is associated with poor prognosis of esophageal squamous cancer. (PubMed id 21951916)1 Xia Z.K....Hu Y.R. (2012)
    97. Short-term eltrombopag for surgical preparation of a p atient with inherited thrombocytopenia deriving from MYH9 mutation. (PubMed id 22398565)1 Pecci A....Balduini C.L. (2012)
    98. [Clinical manifestations and gene mutations of a Chine se family with MYH9-related syndrome]. (PubMed id 22989438)1 Shi R.M....Liu Z.G. (2012)
    99. A Trp33Arg mutation at exon 1 of the MYH9 gene in a Ko rean patient with May-Hegglin anomaly. (PubMed id 22477015)1 Jang M.J....Oh D. (2012)
    100. Glomerular MYH9 expression is reduced by HIV-1. (PubMed id 22313957)1 Hays T....Klotman P.E. (2012)
    101. Polymorphisms in MYH9 are associated with diabetic nep hropathy in European Americans. (PubMed id 21968013)1 Cooke J.N....Bowden D.W. (2012)
    102. Polymorphisms in the non-muscle myosin heavy chain gen e (MYH9) are associated with lower glomerular filtration rate in mixed ancestry diabetic subjects from South Africa. (PubMed id 23285077)1 Matsha T.E....Kengne A.P. (2012)
    103. Role of MYH9 and APOL1 in African and non-African popu lations with lupus nephritis. (PubMed id 22189356)1 Lin C.P....Montgomery C.G. (2012)
    104. Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (2012)
    105. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    106. A large family with MYH9 disorder caused by E1841K mut ation suffering from serious kidney and hearing impairment and cataracts. (PubMed id 22080149)1 Hao J....Gao W. (2012)
    107. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    108. Sp1 phosphorylation by cyclin-dependent kinase 1/cycli n B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)1 Chuang J.Y....Hung J.J. (2012)
    109. Early diagnosis improves the quality of life in MYH9 disorder. (PubMed id 21796764)1 Shiota M....Hata D. (2012)
    110. Proteomic analysis of a4b1 integrin adhesion complexes reveals a-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (2012)
    111. Crystal structure of the S100A4-nonmuscle myosin IIA t ail fragment complex reveals an asymmetric target binding mechanism. (PubMed id 22460785)1 Kiss B....Nyitray L. (2012)
    112. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    113. Non-muscle myosin II is an independent predictor of ov erall survival for cystectomy candidates with early-stage bladder cancer. (PubMed id 22895805)1 Xiong D....Zeng M.S. (2012)
    114. Sulfiredoxin redox-sensitive interaction with S100A4 a nd non-muscle myosin IIA regulates cancer cell motility. (PubMed id 22934964)1 Bowers R.R....Tew K.D. (2012)
    115. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    116. Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
    117. Alteration of liver enzymes is a feature of the MYH9-r elated disease syndrome. (PubMed id 22558294)1 Pecci A....Gresele P. (2012)
    118. Crawling from soft to stiff matrix polarizes the cytos keleton and phosphoregulates myosin-II heavy chain. (PubMed id 23128239)1 Raab M....Discher D.E. (2012)
    119. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    120. S100P dissociates myosin IIA filaments and focal adhes ion sites to reduce cell adhesion and enhance cell migration. (PubMed id 22399300)1 Du M....Rudland P.S. (2012)
    121. Application of the wheat-germ cell-free translation system to produce high temperature requirement A3 (HtrA3) proteases. (PubMed id 22229724)2 Singh H.... Nie G. (2012)
    122. Asymmetric mode of Ca^^+-S100A4 interaction with nonmu scle myosin IIA generates nanomolar affinity required for filament remodeling. (PubMed id 22483112)1 Elliott P.R....Barsukov I.L. (2012)
    123. Nonmuscle myosin IIA facilitates vesicle trafficking f or MG53-mediated cell membrane repair. (PubMed id 22253476)1 Lin P....Ma J. (2012)
    124. MYBPH inhibits NM IIA assembly via direct interaction with NMHC IIA and reduces cell motility. (PubMed id 23068101)1 Hosono Y....Takahashi T. (2012)
    125. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    126. Renal manifestations of patients with MYH9-related di sorders. (PubMed id 21210153)1 Han K.H....Cheong H.I. (2011)
    127. Mutations responsible for MYH9-related thrombocytopen ia impair SDF-1-driven migration of megakaryoblastic cells. (PubMed id 21833445)1 Pecci A....Balduini C.L. (2011)
    128. Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
    129. The population genetics of chronic kidney disease: in sights from the MYH9-APOL1 locus. (PubMed id 21537348)1 Rosset S....Skorecki K. (2011)
    130. Angiotensin-II mediates nonmuscle myosin II activation and expression and contributes to human keloid disease progression. (PubMed id 21792479)1 Bond J.E....Levinson H. (2011)
    131. Identification of proteins associated with ligand-acti vated estrogen receptor a in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PubMed id 21182205)1 Tarallo R....Weisz A. (2011)
    132. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PubMed id 21565611)1 Sang L.... Jackson P.K. (2011)
    133. Identification of the myosin heavy polypeptide 9 as a downstream effector of the proprotein convertases in the human colon carcinoma H T-29 cells. (PubMed id 21805244)1 Scamuffa N....Khatib A.M. (2011)
    134. Phosphorylation of the myosin IIA tailpiece regulates single myosin IIA molecule association with lytic granules to promote NK-cell cytotoxicity. (PubMed id 22123909)1 Sanborn K.B....Orange J.S. (2011)
    135. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    136. The MYH9/APOL1 region and chronic kidney disease in E uropean-Americans. (PubMed id 21429915)1 O'Seaghdha C.M....Kao W.H. (2011)
    137. Differential effects of MYH9 and APOL1 risk variants on FRMD3 Association with Diabetic ESRD in African Americans. (PubMed id 21698141)1 Freedman B.I....Bowden D.W. (2011)
    138. MicroRNA let-7f inhibits tumor invasion and metastasi s by targeting MYH9 in human gastric cancer. (PubMed id 21533124)1 Liang S....Fan D. (2011)
    139. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    140. Two functional S100A4 monomers are necessary for regu lating nonmuscle myosin-IIA and HCT116 cell invasion. (PubMed id 21721535)1 House R.P....Bresnick A.R. (2011)
    141. Aberrant expression of the polarity complex atypical PKC and non-muscle myosin IIA in active and inactive inflammatory bowel disease . (PubMed id 21667320)1 Wald F.A....Salas P.J. (2011)
    142. Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion. (PubMed id 21826056)1 Erickson-Johnson M.R.... Oliveira A.M. (2011)
    143. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    144. Polymorphisms in the nonmuscle myosin heavy chain 9 g ene (MYH9) are associated with the progression of IgA nephropathy in Chinese. (PubMed id 21245129)1 Cheng W....Zhang H. (2011)
    145. The role of non-muscle myosin IIA in aggregation and i nvasion of human MCF-7 breast cancer cells. (PubMed id 22161839)1 Derycke L....Bracke M. (2011)
    146. MYH9 related platelet disorders - often unknown and m isdiagnosed. (PubMed id 21567368)1 Althaus K....Greinacher A. (2011)
    147. Purification and identification of endogenous polySUMO conjugates. (PubMed id 21252943)1 Bruderer R....Hay R.T. (2011)
    148. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
    149. Plasma from a case of recurrent idiopathic FSGS pertu rbs non-muscle myosin IIA (MYH9 protein) in human podocytes. (PubMed id 21380797)1 Babayeva S....Torban E. (2011)
    150. Dynamic assembly properties of nonmuscle myosin II is oforms revealed by combination of fluorescence correlation spectroscopy and flu orescence cross-correlation spectroscopy. (PubMed id 21106542)1 Mitsuhashi M....Takahashi M. (2011)
    151. Mechanism of the CaA^+-dependent interaction between S 100A4 and tail fragments of nonmuscle myosin heavy chain IIA. (PubMed id 21110983)1 Badyal S.K....Bagshaw C.R. (2011)
    152. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    153. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    154. The first report of homozygous May-Hegglin anomaly E1 841K mutation. (PubMed id 21083612)1 Poopak B....Saki N. (2011)
    155. Nonmuscle myosin IIA is required for lamellipodia for mation through binding to WAVE2 and phosphatidylinositol 3,4,5-triphosphate. (PubMed id 21184743)1 Morimura S....Takahashi K. (2011)
    156. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    157. MYH9 and APOL1 are both associated with sickle cell d isease nephropathy. (PubMed id 21910715)1 Ashley-Koch A.E....Telen M.J. (2011)
    158. Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. (PubMed id 21081666)1 Greco T.M....Cristea I.M. (2011)
    159. A G to C transversion at the last nucleotide of exon 25 of the MYH9 gene results in a missense mutation rather than in a splicing de fect. (PubMed id 20603234)1 Vettore S....Savoia A. (2010)
    160. Quantitative nanoproteomics for protein complexes (QNa noPX) related to estrogen transcriptional action. (PubMed id 19805454)1 Cheng P.C....Chen S.H. (2010)
    161. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    162. Eltrombopag for the treatment of the inherited thromb ocytopenia deriving from MYH9 mutations. (PubMed id 20844233)1 Pecci A....Balduini C.L. (2010)
    163. Potential effects of MYH9-associated nephropathy on d ialysis and kidney transplant outcomes. (PubMed id 20492585)1 Freedman B.I. and Murea M. (2010)
    164. The protein network surrounding the human telomere re peat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (2010)
    165. The spectrum of MYH9-associated nephropathy. (PubMed id 20299374)1 Bostrom M.A. and Freedman B.I. (2010)
    166. The value of a native milieu: mutated non-muscle myos in IIA does lead to thrombocytopenia. (PubMed id 20723023)1 Ravid K. (2010)
    167. Identification of FBXO25-interacting proteins using an integrated proteomics approach. (PubMed id 20473970)1 Teixeira F.R.... Gomes M.D. (2010)
    168. Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1. (PubMed id 20944748)1 Arii J....Kawaguchi Y. (2010)
    169. MYH9-related disease: Report on five German families and description of a novel mutation. (PubMed id 20221761)1 Savoia A....Ballmaier M. (2010)
    170. Missense mutations in the APOL1 gene are highly assoc iated with end stage kidney disease risk previously attributed to the MYH9 gene . (PubMed id 20635188)1 Tzur S....Skorecki K. (2010)
    171. Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15. (PubMed id 20124285)1 Nelson G.W....Winkler C.A. (2010)
    172. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    173. Proteomic analysis reveals novel binding partners of MIP-T3 in human cells. (PubMed id 20391533)1 Guo C.W....Kitazato K. (2010)
    174. Filament-associated TSGA10 protein is expressed in pr ofessional antigen presenting cells and interacts with vimentin. (PubMed id 20797700)1 Roghanian A....Behnam B. (2010)
    175. Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. (PubMed id 20618440)1 Pozuelo-Rubio M. (2010)
    176. Interaction of c-Cbl with myosin IIA regulates Bleb a ssociated macropinocytosis of Kaposi's sarcoma-associated herpesvirus. (PubMed id 21203488)1 Valiya Veettil M....Chandran B. (2010)
    177. Patients with Epstein-Fechtner syndromes owing to MYH 9 R702 mutations develop progressive proteinuric renal disease. (PubMed id 20200500)1 Sekine T....Kunishima S. (2010)
    178. FCHo proteins are nucleators of clathrin-mediated end ocytosis. (PubMed id 20448150)1 Henne W.M....McMahon H.T. (2010)
    179. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    180. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    181. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    182. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PubMed id 19167051)1 Weinmann L.... Meister G. (2009)
    183. Proteomic analysis of integrin-associated complexes i dentifies RCC2 as a dual regulator of Rac1 and Arf6. (PubMed id 19738201)1 Humphries J.D....Humphries M.J. (2009)
    184. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
    185. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    186. An integrated workflow for charting the human interac tion proteome: insights into the PP2A system. (PubMed id 19156129)1 Glatter T....Gstaiger M. (2009)
    187. Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
    188. Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse . (PubMed id 19454694)1 Sanborn K.B....Orange J.S. (2009)
    189. Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasion. (PubMed id 19147824)1 Babbin B.A....Ivanov A.I. (2009)
    190. Proteomics analysis of nucleolar SUMO-1 target protei ns upon proteasome inhibition. (PubMed id 19596686)1 Matafora V....Bachi A. (2009)
    191. Genome-wide linkage analysis of serum creatinine in t hree isolated European populations. (PubMed id 19387472)1 Pattaro C....Pramstaller P.P. (2009)
    192. In vitro nuclear interactome of the HIV-1 Tat protein . (PubMed id 19454010)1 Gautier V.W....Hall W.W. (2009)
    193. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    194. Multiple regulatory steps control mammalian nonmuscle myosin II assembly in live cells. (PubMed id 18971378)1 Breckenridge M.T....Egelhoff T.T. (2009)
    195. Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. (PubMed id 18318008)2 Han G.... Gu J. (2008)
    196. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    197. The C-terminal tail region of nonmuscle myosin II directs isoform-specific distribution in migrating cells. (PubMed id 18843042)1 Sandquist J.C. and Means A.R. (2008)
    198. Phosphoproteome of resting human platelets. (PubMed id 18088087)2 Zahedi R.P.... Sickmann A. (2008)
    199. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    200. Cellular nonmuscle myosins NMHC-IIA and NMHC-IIB and vertebrate heart looping. (PubMed id 18697221)1 Lu W....Linask K.K. (2008)
    201. Adhesive receptors, extracellular proteins and myosin IIA orchestrate proplatelet formation by human megakaryocytes. (PubMed id 18752571)1 Balduini A....Torti M. (2008)
    202. Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. (PubMed id 19367720)2 Carrascal M.... Abian J. (2008)
    203. Inhibition of 'self' engulfment through deactivation of myosin-II at the phagocytic synapse between human cells. (PubMed id 18332220)1 Tsai R.K. and Discher D.E. (2008)
    204. TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation. (PubMed id 18394644)1 Clark K....van Leeuwen F.N. (2008)
    205. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PubMed id 18850735)1 Fang L.... Huang L. (2008)
    206. MyosinIIa contractility is required for maintenance of platelet structure during spreading on collagen and contributes to thrombus stability. (PubMed id 17645784)1 Calaminus S.D....Watson S.P. (2007)
    207. Supervillin slows cell spreading by facilitating myosin II activation at the cell periphery. (PubMed id 17925381)2 Takizawa N....Luna E.J. (2007)
    208. Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line. (PubMed id 17487921)2 Giorgianni F.... Beranova-Giorgianni S. (2007)
    209. The critical role of myosin IIA in platelet internal contraction. (PubMed id 17488351)1 Johnson G.J....White J.G. (2007)
    210. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    211. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
    212. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PubMed id 17620599)1 Xiao K....Lefkowitz R.J. (2007)
    213. Myosin IIA is required for cytolytic granule exocytosis in human NK cells. (PubMed id 17875677)1 Andzelm M.M....Strominger J.L. (2007)
    214. Myosin IIA regulates cell motility and actomyosin-microtubule crosstalk. (PubMed id 17310241)1 Even-Ram S....Yamada K.M. (2007)
    215. An emerin 'proteome': purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. (PubMed id 17620012)1 Holaska J.M. and Wilson K.L. (2007)
    216. Myosin-IIA heavy-chain phosphorylation regulates the motility of MDA-MB-231 carcinoma cells. (PubMed id 17567956)1 Dulyaninova N.G....Bresnick A.R. (2007)
    217. HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells. (PubMed id 17342744)1 Dall'Era M.A....Liu A.Y. (2007)
    218. Identification and characterization of proteins intera cting with Traf4, an enigmatic p53 target. (PubMed id 16969126)1 Rozan L.M. and El-Deiry W.S. (2006)
    219. Bladder exstrophy and Epstein type congenital macrothrombocytopenia: evidence for a common cause? (PubMed id 16969870)2 Utsch B.... Troebs R.-B. (2006)
    220. Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration. (PubMed id 17020881)1 Sandquist J.C....Means A.R. (2006)
    221. The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin. (PubMed id 16403913)1 Huang Y....Luo Y. (2006)
    222. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    223. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    224. Vertebrate nonmuscle myosin II isoforms rescue small interfering RNA-induced defects in COS-7 cell cytokinesis. (PubMed id 15774463)1 Bao J....Adelstein R.S. (2005)
    225. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)1 Tao W.A.... Aebersold R. (2005)
    226. Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C. (PubMed id 15845534)1 Kim K.Y....Adelstein R.S. (2005)
    227. Vector-capping: a simple method for preparing a high-quality full- length cDNA library. (PubMed id 16106752)1 Kato S.... Kimura T. (2005)
    228. Nucleolar proteome dynamics. (PubMed id 15635413)1 Andersen J.S....Mann M. (2005)
    229. Global phosphoproteome of HT-29 human colon adenocarcinoma cells. (PubMed id 16083285)1 Kim J.-E.... White F.M. (2005)
    230. Interaction of metastasis-inducing S100A4 protein in vivo by fluorescence lifetime imaging microscopy. (PubMed id 15289939)1 Zhang S....Martin-Fernandez M. (2005)
    231. Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. (PubMed id 16139798)2 Giannakopoulos N.V....Zhang D.E. (2005)
    232. Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. (PubMed id 16051665)1 Jung S.Y....Qin J. (2005)
    233. Regulation of myosin-IIA assembly and Mts1 binding by heavy chain phosphorylation. (PubMed id 15865432)1 Dulyaninova N.G....Bresnick A.R. (2005)
    234. Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. (PubMed id 16009940)1 Zhao C.... Krug R.M. (2005)
    235. A proteomic snapshot of the human heat shock protein 90 interactome. (PubMed id 16263121)1 Falsone S.F....Kungl A.J. (2005)
    236. MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes. (PubMed id 14594945)1 Trinczek B....Drewes G. (2004)
    237. Interaction of soluble CD163 with activated T lymphocytes involves its association with non-muscle myosin heavy chain type A. (PubMed id 15479433)1 Timmermann M....Hogger P. (2004)
    238. Heterodimeric interaction and interfaces of S100A1 an d S100P. (PubMed id 15171681)1 Wang G....Barraclough R. (2004)
    239. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PubMed id 15203218)1 Fu G.K....Stuve L.L. (2004)
    240. Two-headed binding of the unphosphorylated nonmuscle heavy meromyosin.ADP complex to actin. (PubMed id 15065866)1 Kovacs M....Sellers J.R. (2004)
    241. Mts1 regulates the assembly of nonmuscle myosin-IIA. (PubMed id 14640694)1 Li Z.H....Bresnick A.R. (2003)
    242. Myosin is an in vivo substrate of the protein tyrosine phosphatase (SHP-1) after mIgM cross-linking. (PubMed id 12705885)1 Baba T....Hozumi N. (2003)
    243. F-actin and myosin II binding domains in supervillin. (PubMed id 12917436)2 Chen Y.... Luna E.J. (2003)
    244. A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling. (PubMed id 12577067)1 Blagoev B....Mann M. (2003)
    245. PKC epsilon is associated with myosin IIA and actin in fibroblasts. (PubMed id 11897493)1 England K....Rumsby M. (2002)
    246. Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes. (PubMed id 12421915)1 Rey M....Sanchez-Madrid F. (2002)
    247. Mutations in human nonmuscle myosin IIA found in patients with May-Hegglin anomaly and Fechtner syndrome result in impaired enzymatic function. (PubMed id 12237319)1 Hu A....Sellers J.R. (2002)
    248. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    249. Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. (PubMed id 10862698)1 Husi H....Grant S.G. (2000)
    250. Autosomal dominant macrothrombocytopenia with leukocyte inclusions (May-Hegglin anomaly) is linked to chromosome 22q12-13. (PubMed id 10914687)1 Kelley M.J....Korczak J.F. (2000)
    251. Conditional expression of a truncated fragment of nonmuscle myosin II-A alters cell shape but not cytokinesis in HeLa cells. (PubMed id 11029059)1 Wei Q. and Adelstein R.S. (2000)
    252. Autosomal-dominant giant platelet syndromes: a hint of the same genetic defect as in Fechtner syndrome owing to a similar genetic linkage to chromosome 22q11-13. (PubMed id 11071640)1 Toren A....Greinacher A. (2000)
    253. Localisation of the gene responsible for fechtner syndrome in a region <600 Kb on 22q11-q13. (PubMed id 11093280)1 Cusano R....Seri M. (2000)
    254. The interface between MyBP-C and myosin: site-directed mutagenesis of the CX myosin-binding domain of MyBP-C. (PubMed id 10672519)1 Miyamoto C.A....Reinach F.C. (1999)
    255. Mapping of a myosin-binding domain and a regulatory phosphorylation site in M-protein, a structural protein of the sarcomeric M band. (PubMed id 9529381)1 Obermann W.M....Furst D.O. (1998)
    256. Effect of Mts1 on the structure and activity of nonmuscle myosin II. (PubMed id 9405067)1 Ford H.L....Zain S.B. (1997)
    257. A five-generation family with late-onset progressive hereditary hearing impairment due to cochleosaccular degeneration. (PubMed id 9390828)1 Lalwani A.K....Luxford W.M. (1997)
    258. Purification and biochemical characterization of myomesin, a myosin-binding and titin-binding protein, from bovine skeletal muscle. (PubMed id 7588733)1 Obermann W.M....Furst D.O. (1995)
    259. Cellular titin localization in stress fibers and interaction with myosin II filaments in vitro. (PubMed id 8063857)1 Eilertsen K.J....Keller T.C. (1994)
    260. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. (PubMed id 8022818)1 Bement W.M....Mooseker M.S. (1994)
    261. Differential localization of myosin-II isozymes in human cultured cells and blood cells. (PubMed id 7699007)1 Maupin P....Pollard T.D. (1994)
    262. Deafness and Heredita ry Hearing Loss Overview (PubMed id 20301607)1 Smith R.J.H....Van Camp G. (1993)
    263. MYH9-Related Disorders (PubMed id 20301740)1 Savoia A. and Balduini C.L. (1993)
    264. Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin. (PubMed id 8424456)1 Shoeman R.L....Traub P. (1993)
    265. Large tidal volume ventilation improves pulmonary gas exchange during lower abdominal surgery in Trendelenburg's position. (PubMed id 1752022)1 Tweed W.A....Lee T.L. (1991)
    266. Effect of C-protein on actomyosin ATPase. (PubMed id 6448079)1 Moos C. and Feng I.N. (1980)
    267. The interaction of C-protein with heavy meromyosin and subfragment-2. (PubMed id 352343)1 Starr R. and Offer G. (1978)
    268. Enzymic and immunochemical properties of lysozyme. Accurate definition of the antigenic site around the disulphide bridge 30-115 (site 3) by 'surface-simulation' synthesis. (PubMed id 603622)1 Lee C.L. and Atassi M.Z. (1977)
    269. [May-Hegglin anomaly--from genome research to clinical laboratory] (PubMed id 14560660)9 Kunishima S. (2003)
    270. Absence of hearing loss in a mouse model for DFNA17 and MYH9-related disease: the use of public gene-targeted ES cell resources. (PubMed id 16630581)9 Parker L.L....Zuo J. (2006)
    271. Detection of unique neutrophil non-muscle myosin heavy chain-A localization by immunofluorescence analysis in MYH9 disorder presented with macrothrombocytopenia without leukocyte inclusions and deafness. (PubMed id 15613099)9 Kunishima S....Saito H. (2005)
    272. [Inhibition of MYH9 expression by short hairpin RNA expression vector in human umbilical vein endothelial cells (HUVEC).] (PubMed id 19068200)9 Huang Y.L....Yu B.Y. (2008)
    273. [The MYH9 syndrome: report of a new case with a new mutation of the MYH9 gene] (PubMed id 16978745)9 Schleinitz N....Harle J.R. (2006)
    274. [Nonmuscle myosin heavy chain 9 gene mutations related disease: a family report] (PubMed id 18458691)9 Hua Y....Lu X. (2008)
    275. [Autosomal dominant macrothrombocytopenia with leukoc yte inclusion bodies and MYH9 disorders] (PubMed id 19489439)9 Kunishima S. (2009)
    276. Alternative splice variants of MYH9. (PubMed id 17997715)9 Li Y....Mhatre A.N. (2008)
    277. Transfection of the mutant MYH9 cDNA reproduces the most typical cellular phenotype of MYH9-related disease in different cell lines. (PubMed id 19046415)9 Panza E....Ravazzolo R. (2008)
    278. First description of somatic mosaicism in MYH9 disorders. (PubMed id 15667538)9 Kunishima S....Saito H. (2005)
    279. [Immunofluorescence localization of inclusion and identification of nonmuscle myosin heavy chain IIA in neutrophils of May-Hegglin anomaly patients] (PubMed id 12930685)9 Yi Y. and Zhang G.S. (2003)
    280. Calcium-dependent threonine phosphorylation of nonmuscle myosin in stimulated RBL-2H3 mast cells. (PubMed id 10945986)9 Buxton D.B. and Adelstein R.S. (2000)
    281. MYH9-related platelet disorders. (PubMed id 19408192)9 Althaus K. and Greinacher A. (2009)
    282. Clinical and molecular genetic analysis of a family w ith macrothrombocytopenia and early onset sensorineural hearing loss. (PubMed id 19285578)9 Mhatre A.N....Lalwani A.K. (2009)
    283. [Expression and function of non-muscle myosin-IIA in Fechtner syndrome] (PubMed id 18718080)9 Yang H.Y....Ruan C.G. (2008)
    284. [Usefulness of immunofluorescence analysis of neutrop hil nonmuscle myosin heavy chain-A for diagnosing in two sisters with May-Heggl in anomaly] (PubMed id 19110523)9 Kimura N....Kunishima S. (2008)
    285. Expression of Myh9 in the mammalian cochlea: localization within the stereocilia. (PubMed id 16862555)9 Mhatre A.N....Lalwani A.K. (2006)
    286. A unique immunofluorescence method promotes accurate diagnosis in MYH9 disorders: a case report. (PubMed id 15342975)9 Yoshinari M....Tsuchiya S. (2004)
    287. MYH9 spectrum of autosomal-dominant giant platelet syndromes: unexpected association with fibulin-1 variant-D inactivation. (PubMed id 14635206)9 Toren A....Rechavi G. (2003)
    288. Essential hypertension and risk of nephropathy: a rea ppraisal. (PubMed id 20051853)9 Murea M. and Freedman B.I. (2010)
    289. CKD in MYH9-related disorders. (PubMed id 19726116)9 Singh N....Venuto R.C. (2009)
    290. Potential donor-recipient MYH9 genotype interactions in posttransplant nephrotic syndrome after pediatric kidney transplantation. (PubMed id 19764949)9 Freedman B.I....Reeves-Daniel A.M. (2009)

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    Entrez Gene: 4627 HGNC: 7579 AceView: MYH9 Ensembl:ENSG00000100345 euGenes: HUgn4627
    ECgene: MYH9 Kegg: 4627 H-InvDB: MYH9

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