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MYH9 Gene

protein-coding   GIFtS: 72
GCID: GC22M036677

Myosin, Heavy Chain 9, Non-Muscle

(Previous names: myosin, heavy polypeptide 9, non-muscle)
(Previous symbol: DFNA17)
  See MYH9-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin, Heavy Chain 9, Non-Muscle1 2     FTNS2 5
DFNA171 2 5     MHA2 5
Nonmuscle Myosin Heavy Chain II-A1 2     Myosin, Heavy Polypeptide 9, Non-Muscle1
Cellular Myosin Heavy Chain, Type A2 3     EPSTS2
Myosin Heavy Chain 92 3     NMHC-II-A2
Myosin Heavy Chain, Non-Muscle IIa2 3     NMMHCA2
Non-Muscle Myosin Heavy Chain A2 3     myosin-92
Non-Muscle Myosin Heavy Chain IIa2 3     Non-Muscle Myosin Heavy Polypeptide 92
NMMHC-IIA2 3     NMMHC-A3
BDPLT62 5     NMMHC II-A3

External Ids:    HGNC: 75791   Entrez Gene: 46272   Ensembl: ENSG000001003457   OMIM: 1607755   UniProtKB: P355793   

Export aliases for MYH9 gene to outside databases

Previous GC identifers: GC22M033322 GC22M034949 GC22M035001 GC22M019645


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYH9 Gene:
This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional
myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and
a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility
and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural
deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian
syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. (provided by
RefSeq, Dec 2011)

GeneCards Summary for MYH9 Gene:
MYH9 (myosin, heavy chain 9, non-muscle) is a protein-coding gene. Diseases associated with MYH9 include myh9-related disorders, and myh9 related thrombocytopenia. GO annotations related to this gene include calmodulin binding and protein homodimerization activity. An important paralog of this gene is MYH8.

UniProtKB/Swiss-Prot: MYH9_HUMAN, P35579
Function: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such
as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal
contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction;
this function is mechanically antagonized by MYH10

summary for MYH9 Gene:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYH9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYH9 gene promoter:
         Max1   USF1   MyoD   Tal-1beta   E47   c-Ets-1   USF-1   Cart-1   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MYH9 promoter sequence
   Search Chromatin IP Primers for MYH9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYH9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q13.1

MYH9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYH9 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M036677:  view genomic region     (about GC identifiers)

Start:
36,677,323 bp from pter      End:
36,784,063 bp from pter
Size:
106,741 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MYH9_HUMAN, P35579 (See protein sequence)
Recommended Name: Myosin-9  
Size: 1960 amino acids; 226532 Da
Subunit: Interacts with PDLIM2 (By similarity). Interacts with SLC6A4 (By similarity). Myosin is a hexameric
protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light
chain subunits (MLC-2). Interacts with RASIP1. Interacts with DDR1 (By similarity). Interacts with SVIL and HTRA3
Sequence caution: Sequence=CAD89954.1; Type=Frameshift; Positions=1890;
3 PDB 3D structures from and Proteopedia for MYH9:
2LNK (3D)        3ZWH (3D)        4ETO (3D)    
Secondary accessions: A8K6E4 O60805 Q60FE2 Q86T83
Alternative splicing: 2 isoforms:  P35579-1   P35579-2   

Explore the universe of human proteins at neXtProt for MYH9: NX_P35579

Explore proteomics data for MYH9 at MOPED

Post-translational modifications: 

  • ISGylated1
  • Ubiquitination2 at Lys8, Lys14, Lys38, Lys102, Lys186, Lys225, Lys261, Lys299, Lys373, Lys403,
                                 Lys637, Lys651, Lys682, Lys760, Lys810, Lys833, Lys835, Lys1234, Lys1392, Lys1445 (see all 21)
  • Modification sites at PhosphoSitePlus

  • See MYH9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002464.1  
    ENSEMBL proteins: 
     ENSP00000216181   ENSP00000384631   ENSP00000414852  
    Reactome Protein details: P35579

    MYH9 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MYH9
    GenScript Custom Purified and Recombinant Proteins Services for MYH9
    Novus Biologicals MYH9 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYH9

     
    Search eBioscience for Proteins for MYH9 

     
    antibodies-online proteins for MYH9 (12 products) 

     
    antibodies-online peptides for MYH9

    MYH9 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MYH9
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for MYH9 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MYH9
    Novus Biologicals MYH9 Antibodies
    Abcam antibodies for MYH9
    Cloud-Clone Corp. Antibodies for MYH9
    ThermoFisher Antibody for MYH9
    antibodies-online antibodies for MYH9 (74 products) 

    MYH9 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MYH9
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MYH9
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MYH9
    Cloud-Clone Corp. CLIAs for MYH9
    Search eBioscience for ELISAs for MYH9 
    antibodies-online kits for MYH9 (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MYHII: Myosins / Myosin superfamily : Class II

    Selected InterPro protein domains (see all 7):
     IPR027401 Myosin-like_IQ_dom
     IPR004009 Myosin_N
     IPR027417 P-loop_NTPase
     IPR000048 IQ_motif_EF-hand-BS
     IPR002928 Myosin_tail

    Graphical View of Domain Structure for InterPro Entry P35579

    ProtoNet protein and cluster: P35579

    4 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB002017 Spectrin repeat
    IPB002928 Myosin tail
    IPB004009 Myosin N-terminal SH3-like domain


    UniProtKB/Swiss-Prot: MYH9_HUMAN, P35579
    Domain: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of
    4 heptapeptides, characteristic for alpha-helical coiled coils
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 myosin head-like domain


    Find genes that share domains with MYH9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYH9_HUMAN, P35579
    Function: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such
    as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal
    contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction;
    this function is mechanically antagonized by MYH10

         Genatlas biochemistry entry for MYH9:
    myosin,motor contractile protein moving towards the "plus" end of actin track,heavy polypeptide 9,non muscle

         Gene Ontology (GO): Selected molecular function terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000146microfilament motor activity IDA12237319
    GO:0000166nucleotide binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003774motor activity NAS12421915
    GO:0003779actin binding IDA15065866
         
    Find genes that share ontologies with MYH9           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MYH9:
     Increased focal adhesion (FA)   Large cells 

         13 MGI mutant phenotypes (inferred from 16 alleles(MGI details for Myh9):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hearing/vestibular/ear 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  nervous system 
     normal  renal/urinary system  vision/eye 

    Find genes that share phenotypes with MYH9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MYH9: Myh9tm1.2Gac Myh9tm1Maco

       genOway: Develop your customized and physiologically relevant rodent model for MYH9

    miRNA
    Products:
        
    miRTarBase miRNAs that target MYH9:
    hsa-mir-193b-3p (MIRT041494), hsa-mir-1296-5p (MIRT036109), hsa-mir-324-3p (MIRT042922), hsa-mir-9-5p (MIRT021471), hsa-mir-149-5p (MIRT045466), hsa-mir-484 (MIRT042190), hsa-mir-124-3p (MIRT002579), hsa-mir-877-3p (MIRT037181), hsa-mir-92a-3p (MIRT049384), hsa-mir-331-3p (MIRT043426)

    Block miRNA regulation of human, mouse, rat MYH9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYH9 (see all 47):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-300 hsa-miR-376b hsa-miR-25 hsa-miR-449a hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidMYH9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MYH9
    Predesigned siRNA for gene silencing in human, mouse, rat MYH9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MYH9

    Clone
    Products:
         
    OriGene clones in human, mouse for MYH9 (see all 5)
    OriGene ORF clones in mouse, rat for MYH9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYH9 (NM_002473)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYH9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYH9
    Addgene plasmids for MYH9 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MYH9
    Browse ESI BIO Cell Lines and PureStem Progenitors for MYH9 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYH9_HUMAN, P35579: Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cell cortex (By similarity).
    Note=Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    extracellular5
    nucleus5
    plasma membrane5
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IDA14508515
    GO:0001726ruffle IDA16403913
    GO:0001772colocalizes with immunological synapse IDA15064761
    GO:0001931uropod IDA15064761
    GO:0005634nucleus IDA14508515

    Find genes that share ontologies with MYH9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYH9 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    2Cell adhesion Integrin mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Development MAG dependent inhibition of neurite outgrowth0.46
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cell adhesion Tight junctions0.33
    3PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    4Semaphorin interactions
    Sema4D in semaphorin signaling0.90
    Semaphorin interactions0.43
    Sema4D induced cell migration and growth-cone collapse0.90
    5Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77


    Find genes that share SuperPaths with MYH9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYH9 (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions

    1 Cell Signaling Technology (CST) Pathway for MYH9
        Cytoskeletal Signaling

    Selected GeneGo (Thomson Reuters) Pathways for MYH9 (see all 6)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Tight junctions

    2 Reactome Pathways for MYH9
        Sema4D induced cell migration and growth-cone collapse
    Regulation of actin dynamics for phagocytic cup formation


    3 Kegg Pathways  (Kegg details for MYH9):
        Tight junction
    Regulation of actin cytoskeleton
    Salmonella infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MYH9: 
              Cell Surface Markers in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MYH9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYH9 (P355791, 2, 3 ENSP000002161814) via UniProtKB, MINT, STRING, and/or I2D (see all 1109)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCLP193381, 2, 3, ENSP000003181954EBI-350338,EBI-346967 MINT-7945693 I2D: score=2 STRING: ENSP00000318195
    YWHAZP631042, 3, ENSP000003095034MINT-7899812 MINT-7900157 I2D: score=2 STRING: ENSP00000309503
    COPS5Q929052, 3, ENSP000003505124MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000350512
    LMNAP025452, 3MINT-7945693 MINT-7899812 MINT-7947479 I2D: score=1 
    YWHAQP273482, 3, ENSP000002380814MINT-7899812 MINT-7900157 I2D: score=1 STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000212meiotic spindle organization IEA--
    GO:0000904cell morphogenesis involved in differentiation ----
    GO:0000910cytokinesis IMP15774463
    GO:0001525angiogenesis IDA16403913
    GO:0001701in utero embryonic development IEA--

    Find genes that share ontologies with MYH9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MYH9 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BTSSelective inhibitor of skeletal muscle myosin II ATPase activity[1576-37-0]
    (R)-(+)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)[1177356-70-5]
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)[856925-71-8]
    (+-)-BlebbistatinSelective inhibitor of myosin II ATPase activity[674289-55-5]

    4 Novoseek inferred chemical compound relationships for MYH9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phorbol 21.5 1 15496418 (1)
    calcium 0 1 18312684 (1)
    threonine 0 1 10945986 (1)
    tyrosine 0 1 19401332 (1)



    Find genes that share compounds with MYH9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYH9 gene: 
    NM_002473.4  

    Unigene Cluster for MYH9:

    Myosin, heavy chain 9, non-muscle
    Hs.474751  [show with all ESTs]
    Unigene Representative Sequence: NM_002473
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216181(uc003apg.3 uc003aph.1) ENST00000475726 ENST00000486218
    ENST00000459960 ENST00000495928 ENST00000473022 ENST00000477189 ENST00000472210
    ENST00000463027 ENST00000401701(uc003api.1) ENST00000456729
    miRNA
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    Block miRNA regulation of human, mouse, rat MYH9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYH9 (see all 47):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-300 hsa-miR-376b hsa-miR-25 hsa-miR-449a hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidMYH9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MYH9
    Clone
    Products:
         
    OriGene clones in human, mouse for MYH9 (see all 5)
    OriGene ORF clones in mouse, rat for MYH9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYH9 (NM_002473)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYH9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYH9
    Addgene plasmids for MYH9 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MYH9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYH9
      QuantiTect SYBR Green Assays in human, mouse, rat MYH9
      QuantiFast Probe-based Assays in human, mouse, rat MYH9

    Additional mRNA sequence: 

    AB191263.1 AB290175.1 AK025219.1 AK025393.1 AK131080.1 AK291609.1 AK304840.1 BC011915.2 
    BC049849.1 BC090921.1 BC111387.1 BC113067.1 BC131741.1 CR456526.1 D11393.1 HQ326701.1 
    L29141.1 M31013.1 M69180.1 M81105.1 

    Selected DOTS entries (see all 58):

    DT.95126859  DT.119239  DT.92464957  DT.95347813  DT.97761844  DT.100659644  DT.100659636  DT.100659653 
    DT.91985714  DT.120655569  DT.95347783  DT.120655540  DT.100659655  DT.120655825  DT.120655658  DT.100659642 
    DT.120655748  DT.120655676  DT.91811745  DT.100659641  DT.102840742  DT.95347683  DT.97867641  DT.120655554 

    Selected AceView cDNA sequences (see all 1191):

    AW511520 CF137349 BE311756 BF806147 BQ433063 BQ440052 H55296 BG990930 
    AI908004 AK131080 BQ890597 AI431976 BQ672665 BQ232553 AA856897 CA429318 
    BQ007816 AI582363 W23678 BQ773542 BU538565 BM454409 CF454148 BM472152 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MYH9 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^
    SP1:                                                  -                             -                                                                           
    SP2:              -                                   -                             -                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36a · 36b ^ 37a · 37b ^ 38a · 38b · 38c ^ 39 ^
    SP1:                          -     -     -     -     -     -     -     -     -     -     -     -     -                                                         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                  -     -   
    SP5:                                                                                                                                                            

    ExUns: 40a · 40b · 40c ^ 41a · 41b ^ 42a · 42b ^ 43 ^ 44a · 44b ^ 45a · 45b · 45c ^ 46a · 46b
    SP1:  -                                                                                       
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:  -     -     -     -                                                                     
    SP5:  -           -     -     -     -                                                         


    ECgene alternative splicing isoforms for MYH9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYH9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTAAAAAA
    MYH9 Expression
    About this image


    MYH9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    MYH9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYH9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.474751

    UniProtKB/Swiss-Prot: MYH9_HUMAN, P35579
    Tissue specificity: In the kidney, expressed in the glomeruli. Also expressed in leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MYH9: 
              Cell Surface Markers in human mouse rat
              Cell Motility in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MYH9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYH9
    QuantiTect SYBR Green Assays in human, mouse, rat MYH9
    QuantiFast Probe-based Assays in human, mouse, rat MYH9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYH9 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myh91 , 5 myosin, heavy polypeptide 9, non-muscle1, 5 90.51(n)1
    97.09(a)1
      15 (36.81 cM)5
    178861  NM_022410.31  NP_071855.21 
     777605875 
    chicken
    (Gallus gallus)
    Aves MYH91 myosin, heavy chain 9, non-muscle 80.91(n)
    92.75(a)
      396469  NM_205477.1  NP_990808.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYH96
    myosin, heavy chain 9, non-muscle
    92(a)
    1 ↔ 1
    5(22047775-22130391)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF055895.12   -- 76.39(n)    AF055895.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045324.12   -- 77.88(n)   393797  BC045324.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta zip3 NOT muscle attachment myosin ATPase 61(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea nmy-13 myosin 50(a)
    (best of 6)
      X(2944856-2952845)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MYO16
    Type II myosin heavy chain, required for wild-type...
    29(a)
    1 → many
    VIII(151666-157452) YHR023W


    ENSEMBL Gene Tree for MYH9 (if available)
    TreeFam Gene Tree for MYH9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYH9 gene
    MYH82  MYH12  MYH22  MYH112  MYH142  MYH102  MYH132  MYH7B2  
    MYH42  MYH32  MYH152  MYH62  MYH72  
    Selected SIMAP similar genes for MYH9 using alignment to 5 protein entries:     MYH9_HUMAN (see all proteins) (see all similar genes):
    FLJ00279    DKFZp686D10126    MYH11    MYH10    MYH14    MYO1C
    MYO1E    MYH7    MYO3B    MYO9B    MYO9B variant protein    MYO15A
    MYO9A    MYH6    MYH2    MYH13    MYH7B    MYO1G

    Find genes that share paralogs with MYH9           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MYH9
    PGOHUM00000263186


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYH9 (see all 2780)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0183164
    Sebastian syndrome (SBS)4--see VAR_0183162 D N mis40--------
    VAR_0183104
    Sebastian syndrome (SBS)4--see VAR_0183102 K N mis40--------
    VAR_0107944
    May-Hegglin anomaly (MHA)4--see VAR_0107942 T I mis40--------
    VAR_0107934
    Deafness, autosomal dominant, 17 (DFNA17)4--see VAR_0107932 R H mis40--------
    VAR_0442264
    Fechtner syndrome (FTNS)4--see VAR_0442262 K Q mis40--------
    VAR_0183174
    May-Hegglin anomaly (MHA)4--see VAR_0183172 D Y mis40--------
    VAR_0107964
    May-Hegglin anomaly (MHA)4--see VAR_0107962 D H mis40--------
    VAR_0360064
    A breast cancer sample4--see VAR_0360062 K N mis40--------
    VAR_0107974
    Sebastian syndrome (SBS)4--see VAR_0107972 E K mis40--------
    VAR_0183114
    Epstein syndrome (EPS)4--see VAR_0183112 R H mis40--------

    HapMap Linkage Disequilibrium report for MYH9 (36677323 - 36784063 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MYH9 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724192CNV Deletion23290073
    esv2724191CNV Deletion23290073
    esv2665599CNV Deletion23128226
    esv1147593CNV Insertion17803354
    nsv915007CNV Loss21882294
    nsv834186CNV Loss17160897
    nsv523911CNV Loss19592680
    nsv834185CNV Loss17160897
    nsv523629CNV Loss19592680
    nsv522931CNV Gain19592680

    Human Gene Mutation Database (HGMD): MYH9
    Locus Specific Mutation Databases (LSDB): MYH9

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYH9
    DNA2.0 Custom Variant and Variant Library Synthesis for MYH9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 160775   
    OMIM disorders: 155100  153640  605249  603622  153650  600208  
    UniProtKB/Swiss-Prot: MYH9_HUMAN, P35579
  • May-Hegglin anomaly (MHA) [MIM:155100]: A disorder characterized by thrombocytopenia, giant platelets and
    Dohle body-like inclusions in peripheral blood leukocytes. appearing as highly parallel paracrystalline bodies.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Sebastian syndrome (SBS) [MIM:605249]: Autosomal dominant macrothrombocytopenia characterized by
    thrombocytopenia, giant platelets and leukocyte inclusions that are smaller and less organized than in
    May-Hegglin anomaly. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Fechtner syndrome (FTNS) [MIM:153640]: Autosomal dominant macrothrombocytopenia characterized by
    thrombocytopenia, giant platelets and leukocyte inclusions that are small and poorly organized. Additionally,
    FTNS is distinguished by Alport-like clinical features of sensorineural deafness, cataracts and nephritis.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Alport syndrome, with macrothrombocytopenia (APSM) [MIM:153650]: An autosomal dominant disorder
    characterized by the association of ocular lesions, sensorineural hearing loss and nephritis (Alport syndrome)
    with platelet defects. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Epstein syndrome (EPS) [MIM:153650]: An autosomal dominant disorder characterized by the association of
    macrothrombocytopathy, sensorineural hearing loss and nephritis. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Deafness, autosomal dominant, 17 (DFNA17) [MIM:603622]: A form of deafness characterized by progressive
    high frequency hearing impairment and cochleosaccular degeneration. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Macrothrombocytopenia and progressive sensorineural deafness (MPSD) [MIM:600208]: An autosomal dominant
    disorder characterized by the association of macrothrombocytopathy and progressive sensorineural hearing loss
    without renal dysfunction. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Note=Subjects with mutations in the motor domain of MYH9 present with severe thrombocytopenia and develop
    nephritis and deafness before the age of 40 years, while those with mutations in the tail domain have a much
    lower risk of noncongenital complications and significantly higher platelet counts. The clinical course of
    patients with mutations in the four most frequently affected residues of MYH9 (responsible for 70% of
    MYH9-related cases) were evaluated. Mutations at residue 1933 do not induce kidney damage or cataracts and cause
    deafness only in the elderly, those in position 702 result in severe thrombocytopenia and produce nephritis and
    deafness at a juvenile age, while alterations at residue 1424 or 1841 result in intermediate clinical pictures
  • Note=Genetic variations in MYH9 are associated with non-diabetic end stage renal disease (ESRD)

  • 13 diseases for MYH9:    
    About MalaCards
    myh9-related disorders    myh9 related thrombocytopenia    deafness, autosomal dominant 17    macrothrombocytopenia and progressive sensorineural deafness
    dfna17 nonsyndromic hearing loss and deafness    mitochondrial complex v deficiency, mitochondrial 2    autosomal dominant alport syndrome    nonsyndromic hearing loss and deafness
    nonsyndromic hearing loss and deafness, mitochondrial    alport syndrome    mitochondrial complex v deficiency    bernard-soulier syndrome
    deafness, autosomal dominant 4b

    5 diseases from the University of Copenhagen DISEASES database for MYH9:
    Thrombocytopenia     Sensorineural hearing loss     Bernard-Soulier syndrome     Kidney disease
    Alport syndrome

    Find genes that share disorders with MYH9           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MYH9 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    may-hegglin anomaly 97.7 30 12930685 (2), 19954613 (1), 11935325 (1), 11943476 (1) (see all 18)
    sebastian syndrome 96.9 6 11935325 (1), 19408192 (1), 10973259 (1), 11159552 (1) (see all 5)
    epsteins syndrome 96.5 11 11943476 (2), 11935325 (1), 17975807 (1), 19408192 (1) (see all 9)
    fechtner syndrome 96.3 8 11752022 (2), 17655694 (2), 18718080 (1), 19408192 (1)
    platelet disorder 82.7 5 11935325 (2), 19645626 (1), 16044442 (1)
    deafness sensorineural 75.6 3 19967157 (1), 10973259 (1), 17655694 (1)
    bernard-soulier syndrome 74.8 4 15477207 (1), 14706930 (1), 14635206 (1), 15529446 (1)
    alports syndrome 73.9 2 12454218 (1), 11590545 (1)
    nephritis 72.1 6 17975807 (1), 19967157 (1), 16978745 (1), 19645626 (1) (see all 6)
    thrombocytopenia 69.7 18 15667538 (1), 15869600 (1), 17241369 (1), 19046415 (1) (see all 12)

    GeneTests: MYH9
    GeneReviews: MYH9
    Genetic Association Database (GAD): MYH9
    Human Genome Epidemiology (HuGE) Navigator: MYH9 (21 documents)

    Export disorders for MYH9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYH9 gene, integrated from 10 sources (see all 342) (see top 10):
    (articles sorted by number of sources associating them with MYH9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans. (PubMed id 19177153)1, 2, 4, 9 Freedman B.I....Bowden D.W. (Kidney Int. 2009)
    2. Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9. (PubMed id 11023810)1, 2, 3, 9 Lalwani A.K....Mhatre A.N. (Am. J. Hum. Genet. 2000)
    3. MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. (PubMed id 18794856)1, 2, 4, 9 Kopp J.B.... Winkler C.A. (Nat. Genet. 2008)
    4. Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes. (PubMed id 1860190)1, 2, 3, 9 Simons M.... Weir L. (Circ. Res. 1991)
    5. Immunofluorescence analysis of neutrophil nonmuscle myosin heavy chain-A in MYH9 disorders: association of subcellular localization with MYH9 mutations. (PubMed id 12533692)1, 2, 9 Kunishima S.... Saito H. (Lab. Invest. 2003)
    6. Expression of the nonmuscle myosin heavy chain IIA in the human kidney and screening for MYH9 mutations in Epstein and Fechtner syndromes. (PubMed id 11752022)1, 2, 9 Arrondel C.... Heidet L. (J. Am. Soc. Nephrol. 2002)
    7. Nonmuscle myosin heavy chain IIA mutations define a spectrum of autosomal dominant macrothrombocytopenias: May-Hegglin anomaly and Fechtner, Sebastian, Epstein, and Alport-like syndromes. (PubMed id 11590545)1, 2, 9 Heath K.E....Martignetti J.A. (Am. J. Hum. Genet. 2001)
    8. Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related disease. (PubMed id 18059020)1, 2, 9 Pecci A.... Savoia A. (Hum. Mutat. 2008)
    9. Macrothrombocytopenia and progressive deafness is due to a mutation in MYH9. (PubMed id 12621333)1, 2, 9 Mhatre A.N.... Lalwani A.K. (Otol. Neurotol. 2003)
    10. The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family Study. (PubMed id 19921264)1, 4, 9 Franceschini N....Cole S.A. (Hum. Genet. 2010)
    11. Mutations in MYH9 exons 1, 16, 26, and 30 are infrequently found in Japanese patients with nonsyndromic deafness. (PubMed id 19645626)1, 4, 9 Kunishima S....Saito H. (Genet Test Mol Biomarkers 2009)
    12. Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with albuminuria in hypertensive African Americans: the HyperGEN study. (PubMed id 19153477)1, 4, 9 Freedman B.I....Hunt S.C. (Am. J. Nephrol. 2009)
    13. Further evidence for the involvement of MYH9 in the etiology of non-syndromic cleft lip with or without cleft palate. (PubMed id 19320731)1, 4, 9 Birnbaum S....Mangold E. (Eur. J. Oral Sci. 2009)
    14. Epstein syndrome: another renal disorder with mutations in the nonmuscle myosin heavy chain 9 gene. (PubMed id 11935325)1, 2, 9 Seri M.... Savoia A. (Hum. Genet. 2002)
    15. Identification of six novel MYH9 mutations and genotype-phenotype relationships in autosomal dominant macrothrombocytopenia with leukocyte inclusions. (PubMed id 11776386)1, 2, 9 Kunishima S....Saito H. (J. Hum. Genet. 2001)
    16. Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes. (PubMed id 10973259)1, 2, 9 Seri M.... Martignetti J.A. (Nat. Genet. 2000)
    17. Association among polymorphisms at MYH9, environmental factors, and nonsyndromic orofacial clefts in western China. (PubMed id 19891592)1, 4, 9 Jia Z.L....Shi B. (DNA Cell Biol. 2010)
    18. African ancestry allelic variation at the MYH9 gene contributes to increased susceptibility to non-diabetic end-stage kidney disease in Hispanic Americans. (PubMed id 20144966)1, 4, 9 Behar D.M....Skorecki K. (Hum. Mol. Genet. 2010)
    19. Genomic screening identifies novel linkages and provides further evidence for a role of MYH9 in nonsyndromic cleft lip and palate. (PubMed id 18716610)1, 4, 9 Chiquet B.T....Hecht J.T. (Eur. J. Hum. Genet. 2009)
    20. RASD2, MYH9, and CACNG2 genes at chromosome 22q12 associated with the subgroup of schizophrenia with non-deficit in sustained attention and executive function. (PubMed id 18571626)1, 4, 9 Liu Y.L....Hwu H.G. (Biol. Psychiatry 2008)
    21. MYH9-related disease: may-Hegglin anomaly, Sebastian syndrome, Fechtner syndrome, and Epstein syndrome are not distinct entities but represent a variable expression of a single illness. (PubMed id 12792306)1, 2, 9 Seri M.... Savoia A. (Medicine (Baltimore) 2003)
    22. Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May- Hegglin anomaly. (PubMed id 10973260)1, 2, 9 Kelley M.J.... Korczak J.F. (Nat. Genet. 2000)
    23. MYH9 is associated with nondiabetic end-stage renal disease in African Americans. (PubMed id 18794854)1, 2, 9 Kao W.H.... Parekh R.S. (Nat. Genet. 2008)
    24. Asp1424Asn MYH9 mutation results in an unstable protein responsible for the phenotypes in May-Hegglin anomaly/Fechtner syndrome. (PubMed id 12649151)1, 2, 9 Deutsch S.... Beris P. (Blood 2003)
    25. Application of a diagnostic algorithm for inherited thrombocytopenias to 46 consecutive patients. (PubMed id 15477207)1, 4, 9 Noris P....Balduini C.L. (Haematologica 2004)
    26. Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. (PubMed id 20395239)1, 4 Macgregor S....Mackey D.A. (Hum. Mol. Genet. 2010)
    27. A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9. (PubMed id 20668430)1, 4 Genovese G....Pollak M.R. (Kidney Int. 2010)
    28. Candidate genes for non-diabetic ESRD in African Americans: a genome-wide association study using pooled DNA. (PubMed id 20532800)1, 4 Bostrom M.A....Freedman B.I. (Hum. Genet. 2010)
    29. Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: a three-stage case-control association study. (PubMed id 20188514)1, 4 Amagane H....Someya T. (Schizophr. Res. 2010)
    30. Worldwide distribution of the MYH9 kidney disease susceptibility alleles and haplotypes: evidence of historical selection in Africa. (PubMed id 20634883)1, 4 Oleksyk T.K....Winkler C.A. (PLoS ONE 2010)
    31. The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans. (PubMed id 20523037)1, 4 Freedman B.I....Kimberly R.P. (Am. J. Nephrol. 2010)
    32. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    33. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    34. Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD. (PubMed id 19567477)1, 4 Freedman B.I....Bowden D.W. (Nephrol. Dial. Transplant. 2009)
    35. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    36. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
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    41. Human nonmuscle myosin heavy chain mRNA: generation of diversity through alternative polyadenylylation. (PubMed id 1967836)1, 2 Saez C.G.... Leinwand L.A. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    42. Differential expression of wild-type and mutant NMMHC-IIA polypeptides in blood cells suggests cell-specific regulation mechanisms in MYH9 disorders. (PubMed id 18192507)1, 9 Kunishima S....Saito H. (Blood 2008)
    43. Signaling via the angiotensin-converting enzyme results in the phosphorylation of the nonmuscle myosin heavy chain IIA. (PubMed id 16186248)1, 9 Kohlstedt K....Fleming I. (Mol. Pharmacol. 2006)
    44. Pathogenetic mechanisms of hematological abnormalities of patients with MYH9 mutations. (PubMed id 16162639)1, 9 Pecci A....Torti M. (Hum. Mol. Genet. 2005)
    45. MYH9-siRNA and MYH9 mutant alleles: expression in cultured cell lines and their effects upon cell structure and function. (PubMed id 18330899)1, 9 Li Y....Lalwani A.K. (Cell Motil. Cytoskeleton 2008)
    46. Haematological characteristics of MYH9 disorders due to MYH9 R702 mutations. (PubMed id 17241369)1, 9 Kunishima S....Saito H. (Eur. J. Haematol. 2007)
    47. Heavy chain myosin 9-related disease (MYH9 -RD): neutrophil inclusions of myosin-9 as a pathognomonic sign of the disorder. (PubMed id 20174760)1, 9 Savoia A....Pecci A. (Thromb. Haemost. 2010)
    48. Analysis of clinical manifestations, mutant gene and encoded protein in two Chinese MYH9-related disease families. (PubMed id 16806139)1, 9 Yi Y....Ma J. ( international journal of clinical chemistry 2006)
    49. Genetics of focal segmental glomerulosclerosis and human immunodeficiency virus-associated collapsing glomerulopathy: the role of MYH9 genetic variation. (PubMed id 20347641)1, 9 Winkler C.A....Kopp J.B. (Semin. Nephrol. 2010)
    50. Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO mice. (PubMed id 15555549)1, 9 Matsushita T....Saito H. (Biochem. Biophys. Res. Commun. 2004)
    51. Genetics, clinical and pathological features of glomerulonephritis associated with mutations of nonmuscle myosin IIA (Fechtner syndrome). (PubMed id 12500226)1, 9 Ghiggeri G.M....Balduini C.L. (Am. J. Kidney Dis. 2003)
    52. Cloning of the murine non-muscle myosin heavy chain IIA gene ortholog of human MYH9 responsible for May-Hegglin, Sebastian, Fechtner, and Epstein syndromes. (PubMed id 11943476)1, 9 D'Apolito M....Savoia A. (Gene 2002)
    53. Identification of the first in cis mutations in MYH9 disorder. (PubMed id 19191864)1, 9 Miyajima Y. and Kunishima S. (Eur. J. Haematol. 2009)
    54. High-resolution melting analysis for detection of MYH9 mutations. (PubMed id 18925516)1, 9 Provaznikova D....Rittich S. (Platelets 2008)
    55. Identification and characterization of the first large deletion of the MYH9 gene associated with MYH9 disorders. (PubMed id 18284620)1, 9 Kunishima S....Saito H. (Eur. J. Haematol. 2008)
    56. Clinical manifestation and molecular genetic characterization of MYH9 disorders. (PubMed id 19557653)1, 9 Provaznikova D....Rittich S. (Platelets 2009)
    57. Identification of three in-frame deletion mutations in MYH9 disorders suggesting an important hot spot for small rearrangements in MYH9 exon 24. (PubMed id 19459928)1, 9 Miyazaki K....Higashihara M. (Eur. J. Haematol. 2009)
    58. [A non-familial May-Hegglin anomaly accompanying with MYH9 gene R1933X mutation and I1626V polymorphism]. (PubMed id 19954613)1, 9 Li Y....Fang M.Y. (Zhonghua Xue Ye Xue Za Zhi 2009)
    59. In vitro expression and characterization of MYH9 mutant alleles linked to hereditary hearing loss. (PubMed id 20416459)1, 9 Wei C.C....Mhatre A.N. (Otolaryngol Head Neck Surg 2010)
    60. Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration. (PubMed id 18195072)1, 9 Morin N.A....Kim M. (J. Exp. Med. 2008)
    61. Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9. (PubMed id 16567366)1, 9 Kadam K.M....Natraj U. (Mol. Hum. Reprod. 2006)
    62. Expression of non-muscle type myosin heavy polypeptide 9 (MYH9) in mammalian cells. (PubMed id 14706930)1, 9 Takubo T....Hino M. (Eur J Histochem 2003)
    63. Immunocytochemistry for the heavy chain of the non-muscle myosin IIA as a diagnostic tool for MYH9-related disorders. (PubMed id 11918549)1, 9 Pecci A....Balduini C.L. (Br. J. Haematol. 2002)
    64. Mutations in the NMMHC-A gene cause autosomal dominant macrothrombocytopenia with leukocyte inclusions (May-Hegglin anomaly/Sebastian syndrome). (PubMed id 11159552)1, 9 Kunishima S....Saito H. (Blood 2001)
    65. Gene-gene and gene-environment interactions in HIV-associated nephropathy: A focus on the MYH9 nephropathy susceptibility gene. (PubMed id 20005488)1, 9 NA_A+ez M....Freedman B.I. (Adv Chronic Kidney Dis 2010)
    66. MYH9 related disease: four novel mutations of the tail domain of myosin-9 correlating with a mild clinical phenotype. (PubMed id 20002731)1, 9 Pecci A....Savoia A. (Eur. J. Haematol. 2010)
    67. [May-Hegglin anomaly: past and present--novel diagnostic test and new concept of the disease]. (PubMed id 19227191)1, 9 Kunishima S. (Rinsho Byori 2009)
    68. MYH9 related disease: a novel missense Ala95Asp mutation of the MYH9 gene. (PubMed id 19860543)1, 9 de Rocco D....Savoia A. (Platelets 2009)
    69. Identification of the first duplication in MYH9-related disease: a hot spot for unequal crossing-over within exon 24 of the MYH9 gene. (PubMed id 19450438)1, 9 De Rocco D....Savoia A. (Eur J Med Genet 2009)
    70. Cleft lip with or without cleft palate: implication of the heavy chain of non-muscle myosin IIA. (PubMed id 17337617)1, 9 Martinelli M....Savoia A. (J. Med. Genet. 2007)
    71. Non-muscle myosin heavy chain IIA and IIB interact and co-localize in living cells: relevance for MYH9-related disease. (PubMed id 16596254)1, 9 Marini M....Ravazzolo R. (Int. J. Mol. Med. 2006)
    72. A single class II myosin modulates T cell motility and stopping, but not synapse formation. (PubMed id 15064761)1, 9 Jacobelli J....Krummel M.F. (Nat. Immunol. 2004)
    73. Defective expression of GPIb/IX/V complex in platelets from patients with May-Hegglin anomaly and Sebastian syndrome. (PubMed id 12217806)1, 9 Di Pumpo M....Balduini C.L. (Haematologica 2002)
    74. The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA. (PubMed id 19401332)1, 9 Huang Y.... Vogel W.F. (J. Cell Sci. 2009)
    75. Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA. (PubMed id 18812466)1, 9 Chu C.C....Chiorazzi N. (Blood 2008)
    76. An MYH9 human disease model in flies: site-directed mutagenesis of the Drosophila non-muscle myosin II results in hypomorphic alleles with dominant character. (PubMed id 17901043)1, 9 Franke J.D....Kiehart D.P. (Hum. Mol. Genet. 2007)
    77. Cleavage of nonmuscle myosin heavy chain-A during apoptosis in human Jurkat T cells. (PubMed id 15749830)1, 9 Kato M....Imajoh-Ohmi S. (J. Biochem. 2005)
    78. Altered cytoskeleton organization in platelets from patients with MYH9-related disease. (PubMed id 15869600)1, 9 Canobbio I....Torti M. (J. Thromb. Haemost. 2005)
    79. Non-muscle myosin heavy chain (MYH9): a new partner fused to ALK in anaplastic large cell lymphoma. (PubMed id 12800156)1, 9 Lamant L....Espinos E. (amp 2003)
    80. Menin, a tumor suppressor, associates with nonmuscle myosin II-A heavy chain. (PubMed id 14508515)1, 9 Obungu V.H....Marx S.J. (Oncogene 2003)
    81. Protein complexes involving alpha v beta 3 integrins, nonmuscle myosin heavy chain-A, and focal adhesion kinase from in thrombospondin-treated smooth muscle cells. (PubMed id 10822899)1, 9 Sajid M....Stouffer G.A. (J. Investig. Med. 2000)
    82. Megakaryocytes of patients with MYH9-related thrombocytopenia present an altered proplatelet formation. (PubMed id 19572073)1, 9 Pecci A....Balduini A. (Thromb. Haemost. 2009)
    83. Myosin IIA is involved in the endocytosis of CXCR4 induced by SDF-1alpha. (PubMed id 17327270)1, 9 Rey M....SA!nchez-Madrid F. (J. Cell. Sci. 2007)
    84. Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas. (PubMed id 24436421)1 Schramek D....Fuchs E. (Science 2014)
    85. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    86. Intrafusal myosin heavy chain expression of human masseter and biceps muscles at young age shows fundamental similarities but also marked differences. (PubMed id 23306907)1 A9sterlund C....Eriksson P.O. (Histochem. Cell Biol. 2013)
    87. Genetic variation in APOL1 and MYH9 genes is associated with chronic kidney disease among Nigerians. (PubMed id 22956460)1 Tayo B.O....Cooper R.S. (Int Urol Nephrol 2013)
    88. Characterization of three full-length human nonmuscle myosin II paralogs. (PubMed id 24072716)1 Billington N....Sellers J.R. (J. Biol. Chem. 2013)
    89. Association of a novel in-frame deletion mutation of the MYH9 gene with end-stage renal failure: case report and review of the literature. (PubMed id 22541678)1 Ishida M....Kunishima S. (Clin. Nephrol. 2013)
    90. A new feature of the MYH9-related syndrome: chronic transaminase elevation. (PubMed id 22806255)1 Favier R....Martignetti J.A. (Hepatology 2013)
    91. Association between a MYH9 polymorphism (rs3752462) and renal function in the Spanish RENASTUR cohort. (PubMed id 23470845)1 Tavira B....Alvarez V. (Gene 2013)
    92. Epistatic role of the MYH9/APOL1 region on familial hematuria genes. (PubMed id 23516419)1 Voskarides K....Deltas C. (PLoS ONE 2013)
    93. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    94. MYH9-related disease: five novel mutations expanding the spectrum of causative mutations and confirming genotype/phenotype correlations. (PubMed id 23123319)1 De Rocco D....Pecci A. (Eur J Med Genet 2013)
    95. Characterization of molecules binding to the 70K N-terminal region of fibronectin by IFAST purification coupled with mass spectrometry. (PubMed id 23750785)1 Moussavi-Harami S.F....Beebe D.J. (J. Proteome Res. 2013)
    96. Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy. (PubMed id 23569248)1 Yang Y....Bhalla K.N. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    97. PRBC-derived plasma induces non-muscle myosin type IIA-mediated neutrophil migration and morphologic change. (PubMed id 23083320)1 Yu C....Chin Y.E. (Immunopharmacol Immunotoxicol 2013)
    98. Familial cases with MYH9 disorders caused by MYH9 S96L mutation. (PubMed id 23409987)1 Murayama S....Kunishima S. (Pediatr Int 2013)
    99. A non-enzymatic function of Golgi glycosyltransferases: mediation of Golgi fragmentation by interaction with non-muscle myosin IIA. (PubMed id 23396488)1 Petrosyan A. and Cheng P.W. (Glycobiology 2013)
    100. A family with Bolzano-type Bernard-Soulier syndrome carries a benign A1939T MYH9 mutation. (PubMed id 22372535)1 Sarangi S.N....Chan E.L. (Platelets 2013)
    101. Clinical, pathological, and genetic analysis of ten patients with MYH9-related disease. (PubMed id 23207509)1 Sun X.H....Ruan C.G. (Acta Haematol. 2013)
    102. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    103. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. (PubMed id 23084401)1 Singh G....Moore M.J. (Cell 2012)
    104. Nonmuscle myosin IIA is associated with poor prognosis of esophageal squamous cancer. (PubMed id 21951916)1 Xia Z.K....Hu Y.R. (Dis. Esophagus 2012)
    105. Short-term eltrombopag for surgical preparation of a patient with inherited thrombocytopenia deriving from MYH9 mutation. (PubMed id 22398565)1 Pecci A....Balduini C.L. (Thromb. Haemost. 2012)
    106. [Clinical manifestations and gene mutations of a Chinese family with MYH9-related syndrome]. (PubMed id 22989438)1 Shi R.M....Liu Z.G. (Zhongguo Dang Dai Er Ke Za Zhi 2012)
    107. A Trp33Arg mutation at exon 1 of the MYH9 gene in a Korean patient with May-Hegglin anomaly. (PubMed id 22477015)1 Jang M.J....Oh D. (Yonsei Med. J. 2012)
    108. [Clinical features and gene analyses of six patients with MYH9-related disease]. (PubMed id 22967416)1 Sun X.H....Ruan C.G. (Zhonghua Xue Ye Xue Za Zhi 2012)
    109. Glomerular MYH9 expression is reduced by HIV-1. (PubMed id 22313957)1 Hays T....Klotman P.E. (AIDS 2012)
    110. Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans. (PubMed id 21968013)1 Cooke J.N....Bowden D.W. (Nephrol. Dial. Transplant. 2012)
    111. Polymorphisms in the non-muscle myosin heavy chain gene (MYH9) are associated with lower glomerular filtration rate in mixed ancestry diabetic subjects from South Africa. (PubMed id 23285077)1 Matsha T.E....Kengne A.P. (PLoS ONE 2012)
    112. Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis. (PubMed id 22189356)1 Lin C.P....Montgomery C.G. (Genes Immun. 2012)
    113. Shotgun proteomics and network analysis of ubiquitin-related proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (Mol. Cell. Biochem. 2012)
    114. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    115. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (J Proteomics 2012)
    116. A large family with MYH9 disorder caused by E1841K mutation suffering from serious kidney and hearing impairment and cataracts. (PubMed id 22080149)1 Hao J....Gao W. (Ann. Hematol. 2012)
    117. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    118. Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)1 Chuang J.Y....Hung J.J. (Oncogene 2012)
    119. Early diagnosis improves the quality of life in MYH9 disorder. (PubMed id 21796764)1 Shiota M....Hata D. (amp 2012)
    120. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (Proteomics 2012)
    121. Crystal structure of the S100A4-nonmuscle myosin IIA tail fragment complex reveals an asymmetric target binding mechanism. (PubMed id 22460785)1 Kiss B....Nyitray L. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    122. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    123. Non-muscle myosin II is an independent predictor of overall survival for cystectomy candidates with early-stage bladder cancer. (PubMed id 22895805)1 Xiong D....Zeng M.S. (Oncol. Rep. 2012)
    124. Sulfiredoxin redox-sensitive interaction with S100A4 and non-muscle myosin IIA regulates cancer cell motility. (PubMed id 22934964)1 Bowers R.R....Tew K.D. (Biochemistry 2012)
    125. Identification of rare variants from exome sequence in a large pedigree with autism. (PubMed id 23594493)1 Marchani E.E....Wijsman E.M. (Hum. Hered. 2012)
    126. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    127. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (PLoS ONE 2012)
    128. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    129. Alteration of liver enzymes is a feature of the MYH9-related disease syndrome. (PubMed id 22558294)1 Pecci A....Gresele P. (PLoS ONE 2012)
    130. Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain. (PubMed id 23128239)1 Raab M....Discher D.E. (J. Cell Biol. 2012)
    131. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    132. S100P dissociates myosin IIA filaments and focal adhesion sites to reduce cell adhesion and enhance cell migration. (PubMed id 22399300)1 Du M....Rudland P.S. (J. Biol. Chem. 2012)
    133. Application of the wheat-germ cell-free translation system to produce high temperature requirement A3 (HtrA3) proteases. (PubMed id 22229724)2 Singh H.... Nie G. (BioTechniques 2012)
    134. Asymmetric mode of CaA^a8_-S100A4 interaction with nonmuscle myosin IIA generates nanomolar affinity required for filament remodeling. (PubMed id 22483112)1 Elliott P.R....Barsukov I.L. (Structure 2012)
    135. Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair. (PubMed id 22253476)1 Lin P....Ma J. (FASEB J. 2012)
    136. MYBPH inhibits NM IIA assembly via direct interaction with NMHC IIA and reduces cell motility. (PubMed id 23068101)1 Hosono Y....Takahashi T. (Biochem. Biophys. Res. Commun. 2012)
    137. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    138. Renal manifestations of patients with MYH9-related disorders. (PubMed id 21210153)1 Han K.H....Cheong H.I. (Pediatr. Nephrol. 2011)
    139. Mutations responsible for MYH9-related thrombocytopenia impair SDF-1-driven migration of megakaryoblastic cells. (PubMed id 21833445)1 Pecci A....Balduini C.L. (Thromb. Haemost. 2011)
    140. The population genetics of chronic kidney disease: insights from the MYH9-APOL1 locus. (PubMed id 21537348)1 Rosset S....Skorecki K. (Nat Rev Nephrol 2011)
    141. Angiotensin-II mediates nonmuscle myosin II activation and expression and contributes to human keloid disease progression. (PubMed id 21792479)1 Bond J.E....Levinson H. (Mol. Med. 2011)
    142. Identification of proteins associated with ligand-activated estrogen receptor I+ in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PubMed id 21182205)1 Tarallo R....Weisz A. (Proteomics 2011)
    143. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PubMed id 21565611)1 Sang L.... Jackson P.K. (Cell 2011)
    144. Identification of the myosin heavy polypeptide 9 as a downstream effector of the proprotein convertases in the human colon carcinoma HT-29 cells. (PubMed id 21805244)1 Scamuffa N....Khatib A.M. (Methods Mol. Biol. 2011)
    145. Phosphorylation of the myosin IIA tailpiece regulates single myosin IIA molecule association with lytic granules to promote NK-cell cytotoxicity. (PubMed id 22123909)1 Sanborn K.B....Orange J.S. (Blood 2011)
    146. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    147. The MYH9/APOL1 region and chronic kidney disease in European-Americans. (PubMed id 21429915)1 O'Seaghdha C.M....Kao W.H. (Hum. Mol. Genet. 2011)
    148. Differential effects of MYH9 and APOL1 risk variants on FRMD3 Association with Diabetic ESRD in African Americans. (PubMed id 21698141)1 Freedman B.I....Bowden D.W. (PLoS Genet. 2011)
    149. MicroRNA let-7f inhibits tumor invasion and metastasis by targeting MYH9 in human gastric cancer. (PubMed id 21533124)1 Liang S....Fan D. (PLoS ONE 2011)
    150. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    151. Two functional S100A4 monomers are necessary for regulating nonmuscle myosin-IIA and HCT116 cell invasion. (PubMed id 21721535)1 House R.P....Bresnick A.R. (Biochemistry 2011)
    152. Aberrant expression of the polarity complex atypical PKC and non-muscle myosin IIA in active and inactive inflammatory bowel disease. (PubMed id 21667320)1 Wald F.A....Salas P.J. (Virchows Arch. 2011)
    153. Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion. (PubMed id 21826056)1 Erickson-Johnson M.R.... Oliveira A.M. (Lab. Invest. 2011)
    154. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    155. Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with the progression of IgA nephropathy in Chinese. (PubMed id 21245129)1 Cheng W....Zhang H. (Nephrol. Dial. Transplant. 2011)
    156. The role of non-muscle myosin IIA in aggregation and invasion of human MCF-7 breast cancer cells. (PubMed id 22161839)1 Derycke L....Bracke M. (Int. J. Dev. Biol. 2011)
    157. MYH9 related platelet disorders - often unknown and misdiagnosed. (PubMed id 21567368)1 Althaus K....Greinacher A. (Klin Padiatr 2011)
    158. Purification and identification of endogenous polySUMO conjugates. (PubMed id 21252943)1 Bruderer R....Hay R.T. (EMBO Rep. 2011)
    159. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (Stem Cells 2011)
    160. Plasma from a case of recurrent idiopathic FSGS perturbs non-muscle myosin IIA (MYH9 protein) in human podocytes. (PubMed id 21380797)1 Babayeva S....Torban E. (Pediatr. Nephrol. 2011)
    161. Dynamic assembly properties of nonmuscle myosin II isoforms revealed by combination of fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy. (PubMed id 21106542)1 Mitsuhashi M....Takahashi M. (J. Biochem. 2011)
    162. Mechanism of the CaA^+-dependent interaction between S100A4 and tail fragments of nonmuscle myosin heavy chain IIA. (PubMed id 21110983)1 Badyal S.K....Bagshaw C.R. (J. Mol. Biol. 2011)
    163. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    164. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    165. The first report of homozygous May-Hegglin anomaly E1841K mutation. (PubMed id 21083612)1 Poopak B....Saki N. (Eur. J. Haematol. 2011)
    166. Nonmuscle myosin IIA is required for lamellipodia formation through binding to WAVE2 and phosphatidylinositol 3,4,5-triphosphate. (PubMed id 21184743)1 Morimura S....Takahashi K. (Biochem. Biophys. Res. Commun. 2011)
    167. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    168. MYH9 and APOL1 are both associated with sickle cell disease nephropathy. (PubMed id 21910715)1 Ashley-Koch A.E....Telen M.J. (Br. J. Haematol. 2011)
    169. Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. (PubMed id 21081666)1 Greco T.M....Cristea I.M. (amp 2011)
    170. A G to C transversion at the last nucleotide of exon 25 of the MYH9 gene results in a missense mutation rather than in a splicing defect. (PubMed id 20603234)1 Vettore S....Savoia A. (Eur J Med Genet 2010)
    171. Quantitative nanoproteomics for protein complexes (QNanoPX) related to estrogen transcriptional action. (PubMed id 19805454)1 Cheng P.C....Chen S.H. (amp 2010)
    172. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    173. Eltrombopag for the treatment of the inherited thrombocytopenia deriving from MYH9 mutations. (PubMed id 20844233)1 Pecci A....Balduini C.L. (Blood 2010)
    174. Potential effects of MYH9-associated nephropathy on dialysis and kidney transplant outcomes. (PubMed id 20492585)1 Freedman B.I. and Murea M. (Semin Dial 2010)
    175. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (PLoS ONE 2010)
    176. The spectrum of MYH9-associated nephropathy. (PubMed id 20299374)1 Bostrom M.A. and Freedman B.I. (Clin J Am Soc Nephrol 2010)
    177. The value of a native milieu: mutated non-muscle myosin IIA does lead to thrombocytopenia. (PubMed id 20723023)1 Ravid K. (J. Thromb. Haemost. 2010)
    178. Identification of FBXO25-interacting proteins using an integrated proteomics approach. (PubMed id 20473970)1 Teixeira F.R.... Gomes M.D. (Proteomics 2010)
    179. Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1. (PubMed id 20944748)1 Arii J....Kawaguchi Y. (Nature 2010)
    180. Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. (PubMed id 20020773)1 Freibaum B.D....Taylor J.P. (J. Proteome Res. 2010)
    181. MYH9-related disease: Report on five German families and description of a novel mutation. (PubMed id 20221761)1 Savoia A....Ballmaier M. (Ann. Hematol. 2010)
    182. Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene. (PubMed id 20635188)1 Tzur S.... Skorecki K. (Hum. Genet. 2010)
    183. Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15. (PubMed id 20124285)1 Nelson G.W....Winkler C.A. (Hum. Mol. Genet. 2010)
    184. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    185. Proteomic analysis reveals novel binding partners of MIP-T3 in human cells. (PubMed id 20391533)1 Guo C.W....Kitazato K. (Proteomics 2010)
    186. Filament-associated TSGA10 protein is expressed in professional antigen presenting cells and interacts with vimentin. (PubMed id 20797700)1 Roghanian A....Behnam B. (Cell. Immunol. 2010)
    187. Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. (PubMed id 20618440)1 Pozuelo-Rubio M. (FEBS J. 2010)
    188. Interaction of c-Cbl with myosin IIA regulates Bleb associated macropinocytosis of Kaposi's sarcoma-associated herpesvirus. (PubMed id 21203488)1 Valiya Veettil M....Chandran B. (PLoS Pathog. 2010)
    189. Patients with Epstein-Fechtner syndromes owing to MYH9 R702 mutations develop progressive proteinuric renal disease. (PubMed id 20200500)1 Sekine T....Kunishima S. (Kidney Int. 2010)
    190. FCHo proteins are nucleators of clathrin-mediated endocytosis. (PubMed id 20448150)1 Henne W.M.... McMahon H.T. (Science 2010)
    191. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    192. Myosin II motor proteins with different functions determine the fate of lamellipodia extension during cell spreading. (PubMed id 20052411)2 Betapudi V. (PLoS ONE 2010)
    193. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    194. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    195. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PubMed id 19167051)1 Weinmann L.... Meister G. (Cell 2009)
    196. Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. (PubMed id 19738201)1 Humphries J.D....Humphries M.J. (Sci Signal 2009)
    197. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (Mol. Cell. Proteomics 2009)
    198. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    199. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    200. An integrated workflow for charting the human interaction proteome: insights into the PP2A system. (PubMed id 19156129)1 Glatter T....Gstaiger M. (Mol. Syst. Biol. 2009)
    201. Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    202. Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse. (PubMed id 19454694)1 Sanborn K.B....Orange J.S. (J. Immunol. 2009)
    203. Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasion. (PubMed id 19147824)1 Babbin B.A....Ivanov A.I. (Am. J. Pathol. 2009)
    204. Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition. (PubMed id 19596686)1 Matafora V....Bachi A. (amp 2009)
    205. Genome-wide linkage analysis of serum creatinine in three isolated European populations. (PubMed id 19387472)1 Pattaro C....Pramstaller P.P. (Kidney Int. 2009)
    206. In vitro nuclear interactome of the HIV-1 Tat protein. (PubMed id 19454010)1 Gautier V.W....Hall W.W. (Retrovirology 2009)
    207. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    208. Multiple regulatory steps control mammalian nonmuscle myosin II assembly in live cells. (PubMed id 18971378)1 Breckenridge M.T....Egelhoff T.T. (Mol. Biol. Cell 2009)
    209. Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. (PubMed id 18318008)2 Han G.... Gu J. (Proteomics 2008)
    210. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    211. The C-terminal tail region of nonmuscle myosin II directs isoform-specific distribution in migrating cells. (PubMed id 18843042)1 Sandquist J.C. and Means A.R. (Mol. Biol. Cell 2008)
    212. Phosphoproteome of resting human platelets. (PubMed id 18088087)2 Zahedi R.P.... Sickmann A. (J. Proteome Res. 2008)
    213. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    214. Cellular nonmuscle myosins NMHC-IIA and NMHC-IIB and vertebrate heart looping. (PubMed id 18697221)1 Lu W....Linask K.K. (Dev. Dyn. 2008)
    215. Adhesive receptors, extracellular proteins and myosin IIA orchestrate proplatelet formation by human megakaryocytes. (PubMed id 18752571)1 Balduini A....Torti M. (J. Thromb. Haemost. 2008)
    216. Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. (PubMed id 19367720)2 Carrascal M.... Abian J. (J. Proteome Res. 2008)
    217. Inhibition of &quot;self&quot; engulfment through deactivation of myosin-II at the phagocytic synapse between human cells. (PubMed id 18332220)1 Tsai R.K. and Discher D.E. (J. Cell Biol. 2008)
    218. TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation. (PubMed id 18394644)1 Clark K....van Leeuwen F.N. (J. Mol. Biol. 2008)
    219. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PubMed id 18850735)1 Fang L.... Huang L. (J. Proteome Res. 2008)
    220. MyosinIIa contractility is required for maintenance of platelet structure during spreading on collagen and contributes to thrombus stability. (PubMed id 17645784)1 Calaminus S.D....Watson S.P. (J. Thromb. Haemost. 2007)
    221. Supervillin slows cell spreading by facilitating myosin II activation at the cell periphery. (PubMed id 17925381)2 Takizawa N.... Luna E.J. (J. Cell Sci. 2007)
    222. Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line. (PubMed id 17487921)2 Giorgianni F.... Beranova-Giorgianni S. (Electrophoresis 2007)
    223. The critical role of myosin IIA in platelet internal contraction. (PubMed id 17488351)1 Johnson G.J....White J.G. (J. Thromb. Haemost. 2007)
    224. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)
    225. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    226. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PubMed id 17620599)1 Xiao K....Lefkowitz R.J. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    227. Myosin IIA is required for cytolytic granule exocytosis in human NK cells. (PubMed id 17875677)1 Andzelm M.M....Strominger J.L. (J. Exp. Med. 2007)
    228. Myosin IIA regulates cell motility and actomyosin-microtubule crosstalk. (PubMed id 17310241)1 Even-Ram S....Yamada K.M. (Nat. Cell Biol. 2007)
    229. An emerin &quot;proteome&quot;: purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. (PubMed id 17620012)1 Holaska J.M. and Wilson K.L. (Biochemistry 2007)
    230. Myosin-IIA heavy-chain phosphorylation regulates the motility of MDA-MB-231 carcinoma cells. (PubMed id 17567956)1 Dulyaninova N.G....Bresnick A.R. (Mol. Biol. Cell 2007)
    231. HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells. (PubMed id 17342744)1 Dall'Era M.A....Liu A.Y. (Prostate 2007)
    232. Identification and characterization of proteins interacting with Traf4, an enigmatic p53 target. (PubMed id 16969126)1 Rozan L.M. and El-Deiry W.S. (amp 2006)
    233. Bladder exstrophy and Epstein type congenital macrothrombocytopenia: evidence for a common cause? (PubMed id 16969870)2 Utsch B.... Troebs R.-B. (Am. J. Med. Genet. A 2006)
    234. Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration. (PubMed id 17020881)1 Sandquist J.C....Means A.R. (J. Biol. Chem. 2006)
    235. The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin. (PubMed id 16403913)1 Huang Y....Luo Y. (Blood 2006)
    236. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    237. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    238. Vertebrate nonmuscle myosin II isoforms rescue small interfering RNA-induced defects in COS-7 cell cytokinesis. (PubMed id 15774463)1 Bao J....Adelstein R.S. (J. Biol. Chem. 2005)
    239. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)1 Tao W.A....Aebersold R. (Nat. Methods 2005)
    240. Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C. (PubMed id 15845534)1 Kim K.Y....Adelstein R.S. (J. Biol. Chem. 2005)
    241. Nucleolar proteome dynamics. (PubMed id 15635413)1 Andersen J.S.... Mann M. (Nature 2005)
    242. Global phosphoproteome of HT-29 human colon adenocarcinoma cells. (PubMed id 16083285)1 Kim J.E....White F.M. (J. Proteome Res. 2005)
    243. Interaction of metastasis-inducing S100A4 protein in vivo by fluorescence lifetime imaging microscopy. (PubMed id 15289939)1 Zhang S....Martin-Fernandez M. (Eur. Biophys. J. 2005)
    244. Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. (PubMed id 16139798)2 Giannakopoulos N.V.... Zhang D.E. (Biochem. Biophys. Res. Commun. 2005)
    245. Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. (PubMed id 16051665)1 Jung S.Y....Qin J. (Mol. Endocrinol. 2005)
    246. Regulation of myosin-IIA assembly and Mts1 binding by heavy chain phosphorylation. (PubMed id 15865432)1 Dulyaninova N.G....Bresnick A.R. (Biochemistry 2005)
    247. Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. (PubMed id 16009940)1 Zhao C.... Krug R.M. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    248. A proteomic snapshot of the human heat shock protein 90 interactome. (PubMed id 16263121)1 Falsone S.F....Kungl A.J. (FEBS Lett. 2005)
    249. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    250. MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes. (PubMed id 14594945)1 Trinczek B....Drewes G. (J. Biol. Chem. 2004)
    251. Interaction of soluble CD163 with activated T lymphocytes involves its association with non-muscle myosin heavy chain type A. (PubMed id 15479433)1 Timmermann M....HAPgger P. (Immunol. Cell Biol. 2004)
    252. Heterodimeric interaction and interfaces of S100A1 and S100P. (PubMed id 15171681)1 Wang G.... Barraclough R. (Biochem. J. 2004)
    253. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PubMed id 15203218)1 Fu G.K....Stuve L.L. (Genomics 2004)
    254. Two-headed binding of the unphosphorylated nonmuscle heavy meromyosin.ADP complex to actin. (PubMed id 15065866)1 KovA!cs M....Sellers J.R. (Biochemistry 2004)
    255. Mts1 regulates the assembly of nonmuscle myosin-IIA. (PubMed id 14640694)1 Li Z.H....Bresnick A.R. (Biochemistry 2003)
    256. Myosin is an in vivo substrate of the protein tyrosine phosphatase (SHP-1) after mIgM cross-linking. (PubMed id 12705885)1 Baba T....Hozumi N. (Biochem. Biophys. Res. Commun. 2003)
    257. F-actin and myosin II binding domains in supervillin. (PubMed id 12917436)2 Chen Y.... Luna E.J. (J. Biol. Chem. 2003)
    258. A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling. (PubMed id 12577067)1 Blagoev B....Mann M. (Nat. Biotechnol. 2003)
    259. PKC epsilon is associated with myosin IIA and actin in fibroblasts. (PubMed id 11897493)1 England K....Rumsby M. (Cell. Signal. 2002)
    260. Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes. (PubMed id 12421915)1 Rey M....SA!nchez-Madrid F. (J. Immunol. 2002)
    261. Mutations in human nonmuscle myosin IIA found in patients with May-Hegglin anomaly and Fechtner syndrome result in impaired enzymatic function. (PubMed id 12237319)1 Hu A....Sellers J.R. (J. Biol. Chem. 2002)
    262. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    263. Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. (PubMed id 10862698)1 Husi H....Grant S.G. (Nat. Neurosci. 2000)
    264. Autosomal dominant macrothrombocytopenia with leukocyte inclusions (May-Hegglin anomaly) is linked to chromosome 22q12-13. (PubMed id 10914687)1 Kelley M.J....Korczak J.F. (Hum. Genet. 2000)
    265. Conditional expression of a truncated fragment of nonmuscle myosin II-A alters cell shape but not cytokinesis in HeLa cells. (PubMed id 11029059)1 Wei Q. and Adelstein R.S. (Mol. Biol. Cell 2000)
    266. Autosomal-dominant giant platelet syndromes: a hint of the same genetic defect as in Fechtner syndrome owing to a similar genetic linkage to chromosome 22q11-13. (PubMed id 11071640)1 Toren A....Greinacher A. (Blood 2000)
    267. Localisation of the gene responsible for fechtner syndrome in a region &lt;600 Kb on 22q11-q13. (PubMed id 11093280)1 Cusano R....Seri M. (Eur. J. Hum. Genet. 2000)
    268. The interface between MyBP-C and myosin: site-directed mutagenesis of the CX myosin-binding domain of MyBP-C. (PubMed id 10672519)1 Miyamoto C.A....Reinach F.C. (J. Muscle Res. Cell. Motil. 1999)
    269. Mapping of a myosin-binding domain and a regulatory phosphorylation site in M-protein, a structural protein of the sarcomeric M band. (PubMed id 9529381)1 Obermann W.M....FA1rst D.O. (Mol. Biol. Cell 1998)
    270. Effect of Mts1 on the structure and activity of nonmuscle myosin II. (PubMed id 9405067)1 Ford H.L....Zain S.B. (Biochemistry 1997)
    271. A five-generation family with late-onset progressive hereditary hearing impairment due to cochleosaccular degeneration. (PubMed id 9390828)1 Lalwani A.K....Luxford W.M. (amp 1997)
    272. Purification and biochemical characterization of myomesin, a myosin-binding and titin-binding protein, from bovine skeletal muscle. (PubMed id 7588733)1 Obermann W.M....FA1rst D.O. (Eur. J. Biochem. 1995)
    273. Cellular titin localization in stress fibers and interaction with myosin II filaments in vitro. (PubMed id 8063857)1 Eilertsen K.J....Keller T.C. (J. Cell Biol. 1994)
    274. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. (PubMed id 8022818)1 Bement W.M.... Mooseker M.S. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    275. Differential localization of myosin-II isozymes in human cultured cells and blood cells. (PubMed id 7699007)1 Maupin P....Pollard T.D. (J. Cell. Sci. 1994)
    276. Deafness and Hereditary Hearing Loss Overview (PubMed id 20301607)1 Pagon R.A....Stephens K. (1993)
    277. MYH9-Related Disorders (PubMed id 20301740)1 Pagon R.A....Stephens K. (1993)
    278. Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin. (PubMed id 8424456)1 Shoeman R.L....Traub P. (Am. J. Pathol. 1993)
    279. Large tidal volume ventilation improves pulmonary gas exchange during lower abdominal surgery in Trendelenburg's position. (PubMed id 1752022)1 Tweed W.A....Lee T.L. (Can J Anaesth 1991)
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    284. Absence of hearing loss in a mouse model for DFNA17 and MYH9-related disease: the use of public gene-targeted ES cell resources. (PubMed id 16630581)9 Parker L.L....Zuo J. (Brain Res. 2006)
    285. Detection of unique neutrophil non-muscle myosin heavy chain-A localization by immunofluorescence analysis in MYH9 disorder presented with macrothrombocytopenia without leukocyte inclusions and deafness. (PubMed id 15613099)9 Kunishima S....Saito H. (Eur. J. Haematol. 2005)
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    289. [Autosomal dominant macrothrombocytopenia with leukocyte inclusion bodies and MYH9 disorders]. (PubMed id 19489439)9 Kunishima S. (Rinsho Byori 2009)
    290. Alternative splice variants of MYH9. (PubMed id 17997715)9 Li Y....Mhatre A.N. (DNA Cell Biol. 2008)

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    Entrez Gene: 4627 HGNC: 7579 AceView: MYH9 Ensembl:ENSG00000100345 euGenes: HUgn4627
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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