Aliases for MYH9 Gene
Aliases for MYH9 Gene
- Myosin Heavy Chain 9 2 3 4 5
- Cellular Myosin Heavy Chain, Type A 3 4
- Nonmuscle Myosin Heavy Chain II-A 2 3
- Non-Muscle Myosin Heavy Chain IIa 3 4
- Non-Muscle Myosin Heavy Chain A 3 4
- NMMHC-IIA 3 4
- Myosin, Heavy Polypeptide 9, Non-Muscle 2
- Non-Muscle Myosin Heavy Polypeptide 9 3
- Myosin Heavy Chain, Non-Muscle IIa 4
- Myosin, Heavy Chain 9, Non-Muscle 3
- Non-Muscle Myosin Heavy Chain 9 3
External Ids for MYH9 Gene
- HGNC: 7579
- Entrez Gene: 4627
- Ensembl: ENSG00000100345
- OMIM: 160775
- UniProtKB: P35579
Previous HGNC Symbols for MYH9 Gene
- DFNA17
Previous GeneCards Identifiers for MYH9 Gene
- GC22M033322
- GC22M034949
- GC22M035001
- GC22M036677
- GC22M019645
Summaries for MYH9 Gene
-
This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011]
GeneCards Summary for MYH9 Gene
MYH9 (Myosin Heavy Chain 9) is a Protein Coding gene. Diseases associated with MYH9 include Fechtner Syndrome and Sebastian Syndrome. Among its related pathways are PAK Pathway and EPH-Ephrin signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity. An important paralog of this gene is MYH10.
UniProtKB/Swiss-Prot for MYH9 Gene
-
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10.
-
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.
Additional gene information for MYH9 Gene
- Monarch Initiative
- Search for MYH9 at DataMed
- Search for MYH9 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYH9 Gene
Genomics for MYH9 Gene
GeneHancer (GH) Regulatory Elements for MYH9 Gene
Promoters and enhancers for MYH9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MYH9 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MYH9 Gene
Genomic Locations for MYH9 Gene
- chr22:36,281,277-36,388,067
- (GRCh38/hg38)
- Size:
- 106,791 bases
- Orientation:
- Minus strand
- chr22:36,677,323-36,784,063
- (GRCh37/hg19)
Genomic View for MYH9 Gene
Genes around MYH9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q12.3 by Ensembl
- 22q12.3 by Entrez Gene
- 22q12.3 by HGNC
MYH9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MYH9 Gene
Proteins for MYH9 Gene
-
Protein details for MYH9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35579-MYH9_HUMAN
- Recommended name:
- Myosin-9
- Protein Accession:
- P35579
- A8K6E4
- O60805
- Q60FE2
- Q86T83
Protein attributes for MYH9 Gene
- Size:
- 1960 amino acids
- Molecular mass:
- 226532 Da
- Quaternary structure:
-
- Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with RASIP1 (By similarity). Interacts with DDR1 (By similarity). Interacts with SLC6A4 (By similarity). Interacts with PDLIM2 (By similarity). Interacts with SVIL (PubMed:12917436, PubMed:17925381). Interacts with HTRA3 (PubMed:22229724). Interacts with Myo7a (By similarity). Interacts with C9orf135 (PubMed:28345668).
- SequenceCaution:
-
- Sequence=CAD89954.1; Type=Frameshift; Positions=1890; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for MYH9 Gene
Protein Expression for MYH9 Gene
Post-translational modifications for MYH9 Gene
- ISGylated.
- Ubiquitination.
- Ubiquitination at isoforms=14, Lys38, isoforms=102, Lys186, Lys261, isoforms=2373, isoforms=2637, isoforms=2760, isoforms=2835, isoforms=1234, isoforms=1392, and Lys1566
Other Protein References for MYH9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for MYH9 (MYH9)
-
Custom Antibody ServicesOriGene Antibodies for MYH9
- Novus Biologicals Antibodies for MYH9
-
Abcam antibodies for MYH9
-
Cloud-Clone Corp. Antibodies for MYH9
- Invitrogen Antibodies for MYH9
- GeneTex MYH9 antibody for MYH9
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MYH9
- Origene Custom Protein Services for MYH9
- Novus Biologicals proteins for MYH9
-
Cloud-Clone Corp. Proteins for MYH9
- Search GeneTex for Proteins for MYH9
-
Abcam proteins for MYH9
Assay Products
No data available for DME Specific Peptides for MYH9 Gene
Domains & Families for MYH9 Gene
Gene Families for MYH9 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for MYH9 Gene
Suggested Antigen Peptide Sequences for MYH9 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P35579UniProtKB/Swiss-Prot:
MYH9_HUMAN :- The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
- Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
- Domain:
-
- The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
- Family:
-
- Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Function for MYH9 Gene
Molecular function for MYH9 Gene
- GENATLAS Biochemistry:
- myosin,motor contractile protein moving towards the "plus" end of actin track,heavy polypeptide 9,non muscle
- UniProtKB/Swiss-Prot Function:
- Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10.
Phenotypes From GWAS Catalog for MYH9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000146 | microfilament motor activity | IDA | 12237319 |
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003723 | RNA binding | IDA,HDA | 22681889 |
| GO:0003774 | motor activity | NAS,IEA | 12421915 |
| GO:0003779 | actin binding | IDA,IEA | 15065866 |
Phenotypes for MYH9 Gene
- MGI mutant phenotypes for MYH9:
-
inferred from 17 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- growth/size/body region phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- embryo phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for MYH9:
-
- shRNA abundance <= 50%
- Lamellipodia cells
- Decreased viability in esophageal squamous lineage
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Effect on mitosis
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Negative genetic interaction between BLM-/- and BLM+/+
Animal Models for MYH9 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MYH9
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MYH9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MYH9 gene
- Search ViGene Biosciences for MYH9
CRISPR Products
-
OriGene CRISPR knockouts for MYH9
- genomics-online: gRNA clones - Search results for available MYH9 gene related products
- Applied Biological Materials CRISPR for MYH9
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MYH9
- GenScript: Design CRISPR guide RNA sequences for MYH9
miRNA for MYH9 Gene
- miRTarBase miRNAs that target MYH9
-
- hsa-mir-124-3p (MIRT002579)
- hsa-mir-9-5p (MIRT021471)
- hsa-mir-1296-5p (MIRT036109)
- hsa-mir-877-3p (MIRT037181)
- hsa-mir-193b-3p (MIRT041494)
- hsa-mir-484 (MIRT042190)
- hsa-mir-324-3p (MIRT042922)
- hsa-mir-331-3p (MIRT043426)
- hsa-mir-149-5p (MIRT045466)
- hsa-mir-92a-3p (MIRT049384)
- hsa-let-7f-5p (MIRT053474)
- hsa-mir-4329 (MIRT448084)
- hsa-mir-4524a-3p (MIRT448085)
- hsa-mir-4538 (MIRT448086)
- hsa-mir-4453 (MIRT448087)
- hsa-mir-6507-5p (MIRT448088)
- hsa-mir-490-3p (MIRT448089)
- hsa-mir-5589-5p (MIRT608729)
- hsa-mir-4731-5p (MIRT608730)
- hsa-mir-150-5p (MIRT608731)
- hsa-mir-186-3p (MIRT608732)
- hsa-mir-520h (MIRT608733)
- hsa-mir-520g-3p (MIRT608734)
- hsa-mir-512-3p (MIRT608735)
- hsa-mir-520e (MIRT608736)
- hsa-mir-520d-3p (MIRT608737)
- hsa-mir-520c-3p (MIRT608738)
- hsa-mir-520b (MIRT608739)
- hsa-mir-520a-3p (MIRT608740)
- hsa-mir-373-3p (MIRT608741)
- hsa-mir-372-3p (MIRT608742)
- hsa-mir-302e (MIRT608743)
- hsa-mir-302d-3p (MIRT608744)
- hsa-mir-302c-3p (MIRT608745)
- hsa-mir-302b-3p (MIRT608746)
- hsa-mir-302a-3p (MIRT608747)
- hsa-mir-93-5p (MIRT608748)
- hsa-mir-526b-3p (MIRT608749)
- hsa-mir-519d-3p (MIRT608750)
- hsa-mir-20b-5p (MIRT608751)
- hsa-mir-20a-5p (MIRT608752)
- hsa-mir-17-5p (MIRT608753)
- hsa-mir-106b-5p (MIRT608754)
- hsa-mir-106a-5p (MIRT608755)
- hsa-mir-6821-5p (MIRT630377)
- hsa-mir-6513-5p (MIRT630378)
- hsa-mir-887-5p (MIRT630379)
- hsa-mir-3913-5p (MIRT630380)
- hsa-mir-3122 (MIRT630381)
- hsa-mir-450a-1-3p (MIRT630382)
- hsa-mir-6779-5p (MIRT630383)
- hsa-mir-6780a-5p (MIRT630384)
- hsa-mir-3689c (MIRT630385)
- hsa-mir-3689b-3p (MIRT630386)
- hsa-mir-3689a-3p (MIRT630387)
- hsa-mir-30b-3p (MIRT630388)
- hsa-mir-1273h-5p (MIRT630389)
- hsa-mir-6788-5p (MIRT630390)
- hsa-mir-30c-2-3p (MIRT630391)
- hsa-mir-30c-1-3p (MIRT630392)
- hsa-mir-7977 (MIRT630393)
- hsa-mir-6799-5p (MIRT630394)
- hsa-mir-6883-5p (MIRT630395)
- hsa-mir-6785-5p (MIRT630396)
- hsa-mir-4728-5p (MIRT630397)
- hsa-mir-149-3p (MIRT630398)
- hsa-mir-7106-5p (MIRT630399)
- hsa-mir-24-3p (MIRT630400)
- hsa-mir-4284 (MIRT630401)
- hsa-mir-4267 (MIRT630402)
- hsa-mir-5196-5p (MIRT667321)
- hsa-mir-4747-5p (MIRT667322)
- hsa-mir-671-5p (MIRT667323)
- hsa-mir-338-3p (MIRT667324)
- hsa-mir-7157-5p (MIRT667325)
- hsa-mir-4310 (MIRT667326)
- hsa-mir-665 (MIRT701652)
- hsa-mir-1305 (MIRT701653)
- hsa-mir-7160-5p (MIRT701654)
- hsa-mir-4722-5p (MIRT701655)
- hsa-mir-1827 (MIRT701656)
- hsa-mir-15b-3p (MIRT701657)
- hsa-mir-4649-3p (MIRT701658)
- hsa-mir-4478 (MIRT701659)
- hsa-mir-4768-3p (MIRT701660)
- hsa-mir-4419b (MIRT701661)
- hsa-mir-3929 (MIRT701662)
- hsa-mir-940 (MIRT701663)
- hsa-mir-6893-5p (MIRT701664)
- hsa-mir-6808-5p (MIRT701665)
- hsa-mir-1193 (MIRT735923)
- hsa-mir-1233-5p (MIRT736250)
- hsa-mir-1294 (MIRT737176)
- hsa-mir-197-3p (MIRT738686)
- hsa-mir-2467-3p (MIRT739279)
- hsa-mir-3136-3p (MIRT740142)
- hsa-mir-3650 (MIRT741874)
- hsa-mir-370-5p (MIRT742551)
- hsa-mir-4257 (MIRT743418)
- hsa-mir-4316 (MIRT744002)
- hsa-mir-4481 (MIRT745110)
- hsa-mir-4688 (MIRT747013)
- hsa-mir-4745-5p (MIRT748181)
- hsa-mir-486-3p (MIRT749114)
- hsa-mir-5008-5p (MIRT749448)
- hsa-mir-518a-5p (MIRT749896)
- hsa-mir-527 (MIRT750329)
- hsa-mir-548aw (MIRT750630)
- hsa-mir-6743-5p (MIRT754413)
- hsa-mir-6778-5p (MIRT755446)
- hsa-mir-6814-5p (MIRT756760)
- hsa-mir-6818-5p (MIRT756837)
- hsa-mir-6867-5p (MIRT757944)
- hsa-mir-6871-5p (MIRT758025)
- hsa-mir-7155-3p (MIRT759248)
- hsa-mir-8070 (MIRT760085)
miRNA Products
- Search ViGene Biosciences for MYH9
Inhibitory RNA Products
- Origene sirna, RNAi, and shrna products in human, mouse, rat for MYH9
- Browse OriGene Inhibitory RNA Products For MYH9
- genomics-online: shRNA clones - Search results for available MYH9 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MYH9 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MYH9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MYH9
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MYH9
- genomics-online: cdna clones - Search results for available MYH9 gene related products
- orf clones - Search results for available MYH9 gene related products
- Applied Biological Materials Clones for MYH9
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MYH9
-
ViGene Biosciences adenoviral particle packaged cDNA for MYH9 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MYH9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MYH9 gene
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MYH9 Gene
Localization for MYH9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MYH9 Gene
- Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells (PubMed:20052411). In retinal pigment epithelial cells, predominantly localized to stress fiber-like structures with some localization to cytoplasmic puncta (PubMed:27331610). {ECO:0000269 PubMed:20052411, ECO:0000269 PubMed:27331610}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| golgi apparatus | 1 |
- Actin filaments (3)
- Cytosol (3)
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001725 | stress fiber | IEA,IDA | 7699007 |
| GO:0001726 | ruffle | IDA | 16403913 |
| GO:0001772 | colocalizes_with immunological synapse | IEA,IDA | 15064761 |
| GO:0001931 | uropod | IEA,IDA | 15064761 |
| GO:0005634 | nucleus | IDA | 14508515 |
Pathways & Interactions for MYH9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Semaphorin interactions | ||
| 2 | Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases | ||
| 3 | PAK Pathway |
.56
|
|
| 4 | Actin Nucleation by ARP-WASP Complex |
.35
|
|
| 5 | RhoGDI Pathway |
.33
|
|
Pathways by source for MYH9 Gene
1 Cell Signaling Technology pathway for MYH9 Gene
1 BioSystems pathway for MYH9 Gene
18 Reactome pathways for MYH9 Gene
3 KEGG pathways for MYH9 Gene
6 GeneGo (Thomson Reuters) pathways for MYH9 Gene
Interacting Proteins for MYH9 Gene
Selected Interacting proteins:
ENSP00000216181
P35579-MYH9_HUMAN
for MYH9 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000212 | meiotic spindle organization | IEA | -- |
| GO:0000904 | cell morphogenesis involved in differentiation | IEA | -- |
| GO:0001525 | angiogenesis | IDA | 16403913 |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0001768 | establishment of T cell polarity | IEA | -- |
Drugs & Compounds for MYH9 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| (R)-(+)-Blebbistatin | Pharma | non-muscle myosin II ATPases inhibitor, cell-permeable, Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) | 0 | |||
| BTS | Pharma | Selective inhibitor of skeletal muscle myosin II ATPase activity | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (+-)-Blebbistatin |
|
674289-55-5 |
|
|
||
| (S)-(-)-Blebbistatin |
|
856925-71-8 |
|
|
(4) Tocris Compounds for MYH9 Gene
| Compound | Action | Cas Number |
|---|---|---|
| (+-)-Blebbistatin | Selective inhibitor of myosin II ATPase activity | 674289-55-5 |
| (R)-(+)-Blebbistatin | Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) | 1177356-70-5 |
| (S)-(-)-Blebbistatin | Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760) | 856925-71-8 |
| BTS | Selective inhibitor of skeletal muscle myosin II ATPase activity | 1576-37-0 |
Transcripts for MYH9 Gene
mRNA/cDNA for MYH9 Gene
- (6) REFSEQ mRNAs :
- (20) Additional mRNA sequences :
- (1191) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MYH9 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MYH9
- genomics-online: gRNA clones - Search results for available MYH9 gene related products
- Applied Biological Materials CRISPR for MYH9
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MYH9
- GenScript: Design CRISPR guide RNA sequences for MYH9
miRNA Products
- Search ViGene Biosciences for MYH9
Inhibitory RNA Products
- Origene sirna, RNAi, and shrna products in human, mouse, rat for MYH9
- Browse OriGene Inhibitory RNA Products For MYH9
- genomics-online: shRNA clones - Search results for available MYH9 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MYH9 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MYH9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MYH9
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MYH9
- genomics-online: cdna clones - Search results for available MYH9 gene related products
- orf clones - Search results for available MYH9 gene related products
- Applied Biological Materials Clones for MYH9
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
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| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 22 | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26a | · | 26b | ^ | 27 | ^ | 28a | · | 28b | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35a | · | 35b | ^ | 36a | · | 36b | ^ | 37a | · | 37b | ^ | 38a | · | 38b | · | 38c | ^ | 39 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ExUns: | 40a | · | 40b | · | 40c | ^ | 41a | · | 41b | ^ | 42a | · | 42b | ^ | 43 | ^ | 44a | · | 44b | ^ | 45a | · | 45b | · | 45c | ^ | 46a | · | 46b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | - |
Expression for MYH9 Gene
mRNA differential expression in normal tissues according to GTEx for MYH9 Gene
This gene is overexpressed in Artery - Aorta (x4.9).
This gene is overexpressed in Bone marrow mesenchymal stem cell (17.6) and Bone marrow stromal cell (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYH9 Gene
NURSA nuclear receptor signaling pathways regulating expression of MYH9 Gene:
MYH9SOURCE GeneReport for Unigene cluster for MYH9 Gene:
Hs.474751mRNA Expression by UniProt/SwissProt for MYH9 Gene:
P35579-MYH9_HUMAN
Tissue specificity:
In the kidney, expressed in the glomeruli. Also expressed in leukocytes.
Evidence on tissue expression from TISSUES for MYH9 Gene
- Liver(4.9)
- Blood(4.8)
- Lung(4.8)
- Nervous system(4.8)
- Intestine(4.7)
- Gall bladder(4.1)
- Heart(4.1)
- Skin(4.1)
- Kidney(3.8)
- Pancreas(3.5)
- Adrenal gland(2.9)
- Bone(2.9)
- Spleen(2.8)
- Bone marrow(2.7)
- Muscle(2.7)
- Stomach(2.7)
- Eye(2.6)
- Thyroid gland(2.5)
- Lymph node(2.3)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MYH9 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- nervous
- reproductive
- urinary
Organs:
Head and neck:
- brain
- cerebellum
- cranial nerve
- ear
- eye
- face
- head
- inner ear
- middle ear
- nose
- outer ear
Thorax:
- heart
- heart valve
Abdomen:
- intestine
- kidney
- large intestine
- small intestine
- stomach
Pelvis:
- ureter
- urethra
- urinary bladder
- uterus
Limb:
- forearm
General:
- blood
- blood vessel
- coagulation system
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for MYH9
- genomics-online: primer clones - Search results for available MYH9 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for MYH9 Gene
Orthologs for MYH9 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MYH9 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MYH9 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MYH9 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MYH9 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | MYH9 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Myh9 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC100911597 33 |
|
||
| chicken (Gallus gallus) |
Aves | MYH9 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MYH9 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | myh9 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | myh9b 34 |
|
OneToMany | |
| myh9a 33 34 |
|
||||
| -- 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10217 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | zip 35 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | nmy-1 35 34 |
|
||
| nmy-2 34 |
|
ManyToMany | |||
| F45G2.2 35 |
|
|
|||
| Y11D7A.14 35 |
|
|
|||
| hcp-2 35 |
|
|
|||
| hcp-1 35 |
|
|
|||
| C02F12.7 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MYO1 34 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU00551 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | myp2 33 |
|
- Species where no ortholog for MYH9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MYH9 Gene
Paralogs for MYH9 Gene
(39) SIMAP similar genes for MYH9 Gene using alignment to 5 proteins:
Pseudogenes.org Pseudogenes for MYH9 Gene
Variants for MYH9 Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11089787 | benign, Nonsyndromic Hearing Loss, Dominant, MYH9-related disorder | 36,282,407(-) | C/G | 3_prime_UTR_variant | |
| rs113285582 | conflicting-interpretations-of-pathogenicity, likely-benign, not specified, Nonsyndromic Hearing Loss, Dominant, MYH9-related disorder | 36,302,619(-) | G/A | coding_sequence_variant, synonymous_variant | |
| rs113698937 | benign, likely-benign, not specified, MYH9-related disorder, Nonsyndromic Hearing Loss, Dominant | 36,293,875(-) | G/A | intron_variant | |
| rs114268057 | benign, Nonsyndromic Hearing Loss, Dominant, MYH9-related disorder | 36,282,531(-) | G/T | 3_prime_UTR_variant | |
| rs11549907 | benign, not specified, MYH9-related disorder, Nonsyndromic Hearing Loss, Dominant | 36,288,934(-) | G/A | coding_sequence_variant, synonymous_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4564n100 | CNV | gain | 25217958 |
| esv1147593 | CNV | insertion | 17803354 |
| esv2665599 | CNV | deletion | 23128226 |
| esv2724191 | CNV | deletion | 23290073 |
| esv2724192 | CNV | deletion | 23290073 |
| esv2760715 | CNV | gain | 21179565 |
| esv3568385 | CNV | loss | 25503493 |
| esv3568386 | CNV | loss | 25503493 |
| esv3647682 | CNV | gain | 21293372 |
| esv3647684 | CNV | loss | 21293372 |
| nsv520497 | CNV | gain | 19592680 |
| nsv522931 | CNV | gain | 19592680 |
| nsv523629 | CNV | loss | 19592680 |
| nsv523911 | CNV | loss | 19592680 |
| nsv834185 | CNV | loss | 17160897 |
| nsv834186 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
0.554% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.76;
83.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MYH9 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYH9 Gene
Disorders for MYH9 Gene
(51) MalaCards diseases for MYH9 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fechtner syndrome |
|
|
| sebastian syndrome |
|
|
| epstein syndrome |
|
|
| may-hegglin anomaly |
|
|
| macrothrombocytopenia and progressive sensorineural deafness |
|
Search MYH9 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MYH9_HUMAN- Deafness, autosomal dominant, 17 (DFNA17) [MIM:603622]: A form of deafness characterized by progressive high frequency hearing impairment and cochleosaccular degeneration. {ECO:0000269 PubMed:11023810}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Epstein syndrome (EPSTNS) [MIM:153650]: An autosomal dominant disorder characterized by the association of macrothrombocytopathy, sensorineural hearing loss and nephritis. {ECO:0000269 PubMed:11590545, ECO:0000269 PubMed:11752022, ECO:0000269 PubMed:11935325, ECO:0000269 PubMed:12533692, ECO:0000269 PubMed:12792306, ECO:0000269 PubMed:16969870}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Fechtner syndrome (FTNS) [MIM:153640]: Autosomal dominant macrothrombocytopenia characterized by thrombocytopenia, giant platelets and leukocyte inclusions that are small and poorly organized. Additionally, FTNS is distinguished by Alport-like clinical features of sensorineural deafness, cataracts and nephritis. {ECO:0000269 PubMed:10973259, ECO:0000269 PubMed:11752022, ECO:0000269 PubMed:11776386, ECO:0000269 PubMed:12533692, ECO:0000269 PubMed:12792306}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Macrothrombocytopenia and progressive sensorineural deafness (MPSD) [MIM:600208]: An autosomal dominant disorder characterized by the association of macrothrombocytopathy and progressive sensorineural hearing loss without renal dysfunction. {ECO:0000269 PubMed:12621333}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- May-Hegglin anomaly (MHA) [MIM:155100]: A disorder characterized by thrombocytopenia, giant platelets and Dohle body-like inclusions in peripheral blood leukocytes. appearing as highly parallel paracrystalline bodies. {ECO:0000269 PubMed:10973259, ECO:0000269 PubMed:10973260, ECO:0000269 PubMed:11590545, ECO:0000269 PubMed:11776386, ECO:0000269 PubMed:12533692, ECO:0000269 PubMed:12792306}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Note=Genetic variations in MYH9 are associated with non-diabetic end stage renal disease (ESRD).
- Note=Subjects with mutations in the motor domain of MYH9 present with severe thrombocytopenia and develop nephritis and deafness before the age of 40 years, while those with mutations in the tail domain have a much lower risk of noncongenital complications and significantly higher platelet counts. The clinical course of patients with mutations in the four most frequently affected residues of MYH9 (responsible for 70% of MYH9-related cases) were evaluated. Mutations at residue 1933 do not induce kidney damage or cataracts and cause deafness only in the elderly, those in position 702 result in severe thrombocytopenia and produce nephritis and deafness at a juvenile age, while alterations at residue 1424 or 1841 result in intermediate clinical pictures.
- Sebastian syndrome (SBS) [MIM:605249]: Autosomal dominant macrothrombocytopenia characterized by thrombocytopenia, giant platelets and leukocyte inclusions that are smaller and less organized than in May-Hegglin anomaly. {ECO:0000269 PubMed:12533692}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for MYH9
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for MYH9 Gene
Publications for MYH9 Gene
- Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans. (PMID: 19177153) Freedman BI … Bowden DW (Kidney international 2009) 3 4 22 44 58
- MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. (PMID: 18794856) Kopp JB … Winkler CA (Nature genetics 2008) 3 4 22 44 58
- Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9. (PMID: 11023810) Lalwani AK … Mhatre AN (American journal of human genetics 2000) 2 3 4 22 58
- Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes. (PMID: 1860190) Simons M … Weir L (Circulation research 1991) 2 3 4 22 58
- Association among polymorphisms at MYH9, environmental factors, and nonsyndromic orofacial clefts in western China. (PMID: 19891592) Jia ZL … Shi B (DNA and cell biology 2010) 3 22 44 58
Products for MYH9 Gene
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- Invitrogen Antibodies for MYH9
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for MYH9
- VectorBuilder custom plasmid, inducible vectors for MYH9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MYH9
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MYH9
- antibodies-online: Search results for 109 available MYH9 Antibodies ranked by validation data
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- GeneTex MYH9 antibody for MYH9
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- ViGene Biosciences adenoviral particle packaged cDNA for MYH9 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MYH9 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MYH9 gene
- Search ViGene Biosciences for MYH9
- Horizon Cell Lines for MYH9
- genomics-online: cdna clones - Search results for available MYH9 gene related products
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Sources for MYH9 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (139) VectorBuilder
- (140) SNPedia
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- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
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- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew