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Aliases for MYH7B Gene

Aliases for MYH7B Gene

  • Myosin, Heavy Chain 7B, Cardiac Muscle, Beta 2 3
  • Myosin, Heavy Polypeptide 7B, Cardiac Muscle, Beta 2 3
  • Myosin Heavy Chain 7B, Cardiac Muscle Beta Isoform 3 4
  • Antigen MLAA-21 3 4
  • Slow A MYH14 3 4
  • KIAA1512 4 6
  • MYH14 3 6
  • Myosin Cardiac Muscle Beta Chain 4
  • U937-Associated Antigen 3
  • Myosin-7B 3
  • MHC14 3

External Ids for MYH7B Gene

Previous GeneCards Identifiers for MYH7B Gene

  • GC20P033325
  • GC20P034231
  • GC20P034278
  • GC20P033026
  • GC20P033565
  • GC20P030322

Summaries for MYH7B Gene

Entrez Gene Summary for MYH7B Gene

  • The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined. [provided by RefSeq, Mar 2010]

GeneCards Summary for MYH7B Gene

MYH7B (Myosin, Heavy Chain 7B, Cardiac Muscle, Beta) is a Protein Coding gene. Diseases associated with MYH7B include left ventricular noncompaction. Among its related pathways are RhoGDI Pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYH4.

UniProtKB/Swiss-Prot for MYH7B Gene

  • Involved in muscle contraction.

Gene Wiki entry for MYH7B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYH7B Gene

Genomics for MYH7B Gene

Regulatory Elements for MYH7B Gene

Genomic Location for MYH7B Gene

34,955,901 bp from pter
35,002,437 bp from pter
46,537 bases
Plus strand

Genomic View for MYH7B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYH7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYH7B Gene

Proteins for MYH7B Gene

  • Protein details for MYH7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5JVW7
    • Q6NT44
    • Q6NT57
    • Q6WG75
    • Q96I57
    • Q9NWE2
    • Q9P216

    Protein attributes for MYH7B Gene

    1941 amino acids
    Molecular mass:
    221388 Da
    Quaternary structure:
    • Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
    • Expression does not vary in normal patients compared to patients with acute monocytic leukemia
    • The cardiac alpha isoform is a fast ATPase myosin, while the beta isoform is a slow ATPase
    • Sequence=AAI51243.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA96036.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19310.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI43047.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MYH7B Gene


neXtProt entry for MYH7B Gene

Proteomics data for MYH7B Gene at MOPED

Post-translational modifications for MYH7B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYH7B Gene

No data available for DME Specific Peptides for MYH7B Gene

Domains for MYH7B Gene

Gene Families for MYH7B Gene

  • MYHII :Myosins / Myosin superfamily : Class II

Graphical View of Domain Structure for InterPro Entry



  • A7E2Y1
  • Contains 1 IQ domain.
  • Contains 1 myosin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYH7B: view

Function for MYH7B Gene

Molecular function for MYH7B Gene

UniProtKB/Swiss-Prot Function: Involved in muscle contraction.

Gene Ontology (GO) - Molecular Function for MYH7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 23455924
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYH7B: view

Phenotypes for MYH7B Gene

GenomeRNAi human phenotypes for MYH7B:
genes like me logo Genes that share phenotypes with MYH7B: view

miRNA for MYH7B Gene

miRTarBase miRNAs that target MYH7B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MYH7B Gene

Localization for MYH7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYH7B Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for MYH7B Gene COMPARTMENTS Subcellular localization image for MYH7B gene
Compartment Confidence
cytoskeleton 3
cytosol 3
mitochondrion 3
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for MYH7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016459 myosin complex --
GO:0032982 myosin filament IEA --
genes like me logo Genes that share ontologies with MYH7B: view

Pathways for MYH7B Gene

genes like me logo Genes that share pathways with MYH7B: view

Gene Ontology (GO) - Biological Process for MYH7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0016192 vesicle-mediated transport --
genes like me logo Genes that share ontologies with MYH7B: view

Transcripts for MYH7B Gene

Unigene Clusters for MYH7B Gene

Myosin, heavy chain 7B, cardiac muscle, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYH7B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^
SP4: -
SP5: -
SP10: -
SP11: -

ExUns: 22 ^ 23a · 23b · 23c · 23d
SP5: -
SP11: -

Relevant External Links for MYH7B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYH7B Gene

mRNA expression in normal human tissues for MYH7B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYH7B Gene

This gene is overexpressed in Heart - Left Ventricle (19.1), Heart - Atrial Appendage (10.3), and Muscle - Skeletal (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYH7B Gene

SOURCE GeneReport for Unigene cluster for MYH7B Gene Hs.414122

mRNA Expression by UniProt/SwissProt for MYH7B Gene

Tissue specificity: Expressed in heart, skeletal muscle, testis, and all specific brain regions examined. Slightly lower expression was detected in ovary and kidney, and intermediate expression was detected in lung, pancreas, spleen and liver.
genes like me logo Genes that share expressions with MYH7B: view

Orthologs for MYH7B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYH7B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MYH7B 35
  • 99.63 (n)
  • 99.85 (a)
MYH7B 36
  • 100 (a)
(Bos Taurus)
Mammalia MYH7B 35
  • 91.76 (n)
  • 97.31 (a)
MYH7B 36
  • 97 (a)
(Canis familiaris)
Mammalia MYH7B 35
  • 91.35 (n)
  • 97.44 (a)
MYH7B 36
  • 96 (a)
(Mus musculus)
Mammalia Myh7b 35
  • 89.22 (n)
  • 96.14 (a)
Myh7b 16
Myh7b 36
  • 96 (a)
(Monodelphis domestica)
Mammalia MYH7B 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
(Rattus norvegicus)
Mammalia Myh7b 35
  • 89.32 (n)
  • 96.24 (a)
(Gallus gallus)
Aves MYH7B 35
  • 78.36 (n)
  • 79.63 (a)
MYH7B 36
  • 80 (a)
(Anolis carolinensis)
Reptilia MYH7B 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia myh7b 35
  • 72.33 (n)
  • 78.26 (a)
(Danio rerio)
Actinopterygii myh7 35
  • 69.47 (n)
  • 72.3 (a)
MYH7B (3 of 3) 36
  • 70 (a)
myh7ba 36
  • 73 (a)
myh7bb 36
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mhc 36
  • 52 (a)
(Caenorhabditis elegans)
Secernentea myo-1 36
  • 44 (a)
myo-2 36
  • 45 (a)
myo-3 35
  • 53.78 (n)
  • 48.76 (a)
myo-3 36
  • 47 (a)
myo-5 36
  • 47 (a)
myo-6 36
  • 44 (a)
unc-54 36
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO1 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
-- 36
  • 64 (a)
-- 36
  • 51 (a)
-- 36
  • 65 (a)
-- 36
  • 65 (a)
-- 36
  • 65 (a)
-- 36
  • 65 (a)
Species with no ortholog for MYH7B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYH7B Gene

Gene Tree for MYH7B (if available)
Gene Tree for MYH7B (if available)

Paralogs for MYH7B Gene

Paralogs for MYH7B Gene

genes like me logo Genes that share paralogs with MYH7B: view

Variants for MYH7B Gene

Sequence variations from dbSNP and Humsavar for MYH7B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs733086 -- 34,983,946(+) GGGAA(A/G)GTGAG intron-variant
rs734308 -- 34,984,293(-) TGGAA(C/T)AGACC intron-variant
rs745849 -- 34,984,375(-) CCTCC(C/T)GACTA intron-variant
rs754511 - 34,987,874(-) CGATG(A/T)AGAAC missense, reference
rs1475070 -- 34,975,296(+) GCCTC(C/T)TGGGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MYH7B Gene

Variant ID Type Subtype PubMed ID
nsv912860 CNV Gain 21882294
nsv833962 CNV Loss 17160897
nsv3362 CNV Insertion 18451855

Relevant External Links for MYH7B Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYH7B Gene

Disorders for MYH7B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MYH7B Gene including...

Search for MYH7B Gene in MalaCards »

Relevant External Links for MYH7B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MYH7B: view

No data available for UniProtKB/Swiss-Prot for MYH7B Gene

Publications for MYH7B Gene

  1. Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family. (PMID: 11919279) Desjardins P.R. … Stedman H.H. (Mol. Biol. Evol. 2002) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. Modest association of malignant melanoma with the rs910873 and rs1885120 markers on chromosome 20: a population-based study. (PMID: 20224305) Debniak T. … LubiA8ski J. (Melanoma Res. 2010) 3 48
  4. Common genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population. (PMID: 20520619) Srivastava K. … Mittal B. (J. Hum. Genet. 2010) 3 48
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for MYH7B Gene

Sources for MYH7B Gene

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