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Aliases for MYH7B Gene

Aliases for MYH7B Gene

  • Myosin Heavy Chain 7B 2 3 5
  • Myosin, Heavy Polypeptide 7B, Cardiac Muscle, Beta 2 3
  • Myosin Heavy Chain 7B, Cardiac Muscle Beta Isoform 3 4
  • Antigen MLAA-21 3 4
  • Slow A MYH14 3 4
  • Myosin, Heavy Chain 7B, Cardiac Muscle, Beta 3
  • Myosin Cardiac Muscle Beta Chain 4
  • U937-Associated Antigen 3
  • Myosin-7B 3
  • KIAA1512 4
  • MHC14 3
  • MYH14 3

External Ids for MYH7B Gene

Previous GeneCards Identifiers for MYH7B Gene

  • GC20P033325
  • GC20P034231
  • GC20P034278
  • GC20P033026
  • GC20P033565
  • GC20P030322

Summaries for MYH7B Gene

Entrez Gene Summary for MYH7B Gene

  • The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined. [provided by RefSeq, Mar 2010]

GeneCards Summary for MYH7B Gene

MYH7B (Myosin Heavy Chain 7B) is a Protein Coding gene. Diseases associated with MYH7B include Left Ventricular Noncompaction and Acute Monocytic Leukemia. Among its related pathways are Vesicle-mediated transport and Tight junction. GO annotations related to this gene include nucleotide binding and actin filament binding. An important paralog of this gene is MYH7.

UniProtKB/Swiss-Prot for MYH7B Gene

  • Involved in muscle contraction.

Gene Wiki entry for MYH7B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYH7B Gene

Genomics for MYH7B Gene

Regulatory Elements for MYH7B Gene

Enhancers for MYH7B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F034954 1.2 ENCODE 15.4 +0.1 110 2.7 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 NCOA6 RBM12 PROCR MYH7B ENSG00000272945 CPNE1 RPL36P4 MMP24-AS1 GSS
GH20F034977 0.8 Ensembl ENCODE 15.4 +22.7 22711 1.5 JUND SAP130 ZMYM3 KDM1A MYH7B NCOA6 TRPC4AP GC20P034981 PIR41920 GSS
GH20F035052 0.8 ENCODE 15.2 +96.8 96768 0.8 ELF3 ZNF792 SAP130 ZSCAN9 ZNF644 RARA TEAD3 NR2F6 HOMEZ SOX5 MYH7B MMP24 ENSG00000201151 NCOA6 MMP24-AS1 PIR41538 RNU6-407P
GH20F035017 0.7 ENCODE 15.2 +62.7 62682 2.0 MAFG JUNB TBX21 ZNF316 MAFF IKZF1 EED NBN ZNF600 ETV6 MYH7B MIR499A TRPC4AP EDEM2 MMP24-AS1 PROCR NCOA6 GC20M035031 GC20M034988
GH20F034994 0.8 ENCODE 12.8 +38.7 38736 0.8 ELF3 MXI1 SAP130 MLX ZFP64 ARID4B DMAP1 ZNF48 ZNF644 RARA MYH7B TRPC4AP MMP24-AS1 NCOA6 GC20M034988 GC20M035031
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYH7B on UCSC Golden Path with GeneCards custom track

Promoters for MYH7B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000009167 -235 1201 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for MYH7B Gene

Chromosome:
20
Start:
34,955,835 bp from pter
End:
35,002,437 bp from pter
Size:
46,603 bases
Orientation:
Plus strand

Genomic View for MYH7B Gene

Genes around MYH7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYH7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYH7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYH7B Gene

Proteins for MYH7B Gene

  • Protein details for MYH7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A7E2Y1-MYH7B_HUMAN
    Recommended name:
    Myosin-7B
    Protein Accession:
    A7E2Y1
    Secondary Accessions:
    • Q5JVW7
    • Q6NT44
    • Q6NT57
    • Q6WG75
    • Q96I57
    • Q9NWE2
    • Q9P216

    Protein attributes for MYH7B Gene

    Size:
    1941 amino acids
    Molecular mass:
    221388 Da
    Quaternary structure:
    • Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
    Miscellaneous:
    • Expression does not vary in normal patients compared to patients with acute monocytic leukemia.
    • The cardiac alpha isoform is a fast ATPase myosin, while the beta isoform is a slow ATPase.
    SequenceCaution:
    • Sequence=AAI51243.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA96036.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19310.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI43047.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MYH7B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYH7B Gene

Post-translational modifications for MYH7B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYH7B Gene

Domains & Families for MYH7B Gene

Gene Families for MYH7B Gene

Graphical View of Domain Structure for InterPro Entry

A7E2Y1

UniProtKB/Swiss-Prot:

MYH7B_HUMAN :
  • Contains 1 IQ domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • Contains 1 IQ domain.
  • Contains 1 myosin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYH7B: view

Function for MYH7B Gene

Molecular function for MYH7B Gene

UniProtKB/Swiss-Prot Function:
Involved in muscle contraction.

Gene Ontology (GO) - Molecular Function for MYH7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 23455924
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYH7B: view
genes like me logo Genes that share phenotypes with MYH7B: view

Human Phenotype Ontology for MYH7B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for MYH7B Gene

miRTarBase miRNAs that target MYH7B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MYH7B Gene

Localization for MYH7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYH7B Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYH7B gene
Compartment Confidence
cytoskeleton 4
mitochondrion 3
cytosol 3
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for MYH7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016459 myosin complex IEA --
GO:0032982 myosin filament IEA --
GO:0097512 cardiac myofibril IEA --
genes like me logo Genes that share ontologies with MYH7B: view

Pathways & Interactions for MYH7B Gene

genes like me logo Genes that share pathways with MYH7B: view

Gene Ontology (GO) - Biological Process for MYH7B Gene

None

No data available for SIGNOR curated interactions for MYH7B Gene

Transcripts for MYH7B Gene

Unigene Clusters for MYH7B Gene

Myosin, heavy chain 7B, cardiac muscle, beta:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYH7B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^
SP1:
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11: -

ExUns: 22 ^ 23a · 23b · 23c · 23d
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -

Relevant External Links for MYH7B Gene

GeneLoc Exon Structure for
MYH7B
ECgene alternative splicing isoforms for
MYH7B

Expression for MYH7B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYH7B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYH7B Gene

This gene is overexpressed in Heart - Left Ventricle (x19.1), Heart - Atrial Appendage (x10.3), and Muscle - Skeletal (x5.0).

Protein differential expression in normal tissues from HIPED for MYH7B Gene

This gene is overexpressed in Heart (39.3), Bone marrow stromal cell (14.3), and Cerebrospinal fluid (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYH7B Gene



NURSA nuclear receptor signaling pathways regulating expression of MYH7B Gene:

MYH7B

SOURCE GeneReport for Unigene cluster for MYH7B Gene:

Hs.414122

mRNA Expression by UniProt/SwissProt for MYH7B Gene:

A7E2Y1-MYH7B_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, testis, and all specific brain regions examined. Slightly lower expression was detected in ovary and kidney, and intermediate expression was detected in lung, pancreas, spleen and liver.
genes like me logo Genes that share expression patterns with MYH7B: view

Primer Products

No data available for Protein tissue co-expression partners for MYH7B Gene

Orthologs for MYH7B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYH7B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYH7B 34 35
  • 99.63 (n)
cow
(Bos Taurus)
Mammalia MYH7B 34 35
  • 91.76 (n)
dog
(Canis familiaris)
Mammalia MYH7B 34 35
  • 91.35 (n)
rat
(Rattus norvegicus)
Mammalia Myh7b 34
  • 89.32 (n)
mouse
(Mus musculus)
Mammalia Myh7b 34 16 35
  • 89.22 (n)
oppossum
(Monodelphis domestica)
Mammalia MYH7B 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 56 (a)
OneToMany
chicken
(Gallus gallus)
Aves MYH7B 34 35
  • 78.36 (n)
lizard
(Anolis carolinensis)
Reptilia MYH7B 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myh7b 34
  • 72.33 (n)
zebrafish
(Danio rerio)
Actinopterygii myh7ba 35
  • 73 (a)
OneToMany
myh7bb 35
  • 71 (a)
OneToMany
MYH7B (3 of 3) 35
  • 70 (a)
OneToMany
myh7 34
  • 69.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mhc 35
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea myo-3 34 35
  • 53.78 (n)
myo-5 35
  • 47 (a)
ManyToMany
unc-54 35
  • 47 (a)
ManyToMany
myo-2 35
  • 45 (a)
ManyToMany
myo-1 35
  • 44 (a)
ManyToMany
myo-6 35
  • 44 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO1 35
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 65 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 64 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
Species where no ortholog for MYH7B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYH7B Gene

ENSEMBL:
Gene Tree for MYH7B (if available)
TreeFam:
Gene Tree for MYH7B (if available)

Paralogs for MYH7B Gene

Variants for MYH7B Gene

Sequence variations from dbSNP and Humsavar for MYH7B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs10427424 -- 34,959,107(+) AGTCA(C/G)GTCAA intron-variant
rs10427446 -- 34,960,739(+) AGCCC(C/G)TAGCA intron-variant
rs10536288 -- 34,995,231(+) CAGCC(-/AAA)CTTTG intron-variant
rs1058003 -- 35,002,614(+) ACAGC(A/G)GCCAA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs111253989 -- 34,964,210(+) TTCTG(C/T)ATCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYH7B Gene

Variant ID Type Subtype PubMed ID
nsv1055447 CNV loss 25217958
nsv1063673 CNV loss 25217958
nsv3362 CNV insertion 18451855
nsv833962 CNV loss 17160897

Variation tolerance for MYH7B Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.85; 86.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYH7B Gene

Human Gene Mutation Database (HGMD)
MYH7B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYH7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYH7B Gene

Disorders for MYH7B Gene

MalaCards: The human disease database

(3) MalaCards diseases for MYH7B Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
left ventricular noncompaction
  • left ventricular hypertrabeculation
acute monocytic leukemia
  • acute monoblastic leukemia and acute monocytic leukemia
monocytic leukemia
  • schilling's leukemia
- elite association - COSMIC cancer census association via MalaCards
Search MYH7B in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYH7B

Genetic Association Database (GAD)
MYH7B
Human Genome Epidemiology (HuGE) Navigator
MYH7B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYH7B
genes like me logo Genes that share disorders with MYH7B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYH7B Gene

Publications for MYH7B Gene

  1. Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family. (PMID: 11919279) Desjardins P.R. … Stedman H.H. (Mol. Biol. Evol. 2002) 2 3 4 64
  2. A genome-wide association study of the Protein C anticoagulant pathway. (PMID: 22216198) Athanasiadis G. … Soria J.M. (PLoS ONE 2011) 3 46 64
  3. Common genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population. (PMID: 20520619) Srivastava K. … Mittal B. (J. Hum. Genet. 2010) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Modest association of malignant melanoma with the rs910873 and rs1885120 markers on chromosome 20: a population-based study. (PMID: 20224305) Debniak T. … LubiA8ski J. (Melanoma Res. 2010) 3 46 64

Products for MYH7B Gene

Sources for MYH7B Gene

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