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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYH4 Gene

protein-coding   GIFtS: 56
GCID: GC17M010346

myosin, heavy chain 4, skeletal muscle

(Previous names: myosin, heavy polypeptide 4, skeletal muscle )
 Explore 7 diseases affiliated with
MYH4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MYH4    

Aliases
for MYH4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Myosin, Heavy Chain 4, Skeletal Muscle1 2     Myosin Heavy Chain 42 3
MyHC-IIb1 2 3     Myosin Heavy Chain IIb2 3
MYH2B1 2     Myosin Heavy Chain, Skeletal Muscle, Fetal2 3
MyHC-2B1 2     Myosin-41
Myosin, Heavy Polypeptide 4, Skeletal Muscle1 2     MyHC-2b3
Myosin Heavy Chain 2b2 3     

External Ids:    HGNC: 75741   Entrez Gene: 46222   Ensembl: ENSG000002644247   OMIM: 1607425   UniProtKB: Q9Y6233   

Export aliases for MYH4 gene to outside databases

Previous GC identifers: GC17M010712 GC17M011461 GC17M010289 GC17M010547 GC17M010287


Summaries
for MYH4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MYH4_HUMAN, Q9Y623
Function: Muscle contraction

summary for MYH4:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYH4


Genomic Views
for MYH4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYH4 gene promoter:
         SRF   TBP   AML1a   SRF (504 AA)   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   C/EBPalpha   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MYH4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MYH4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYH4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17pter-p11

MYH4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYH4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M010346:  view genomic region     (about GC identifiers)

Start:
 10,346,607 bp from pter      End:
 10,372,876 bp from pter
Size:
 26,270 bases      Orientation:
 minus strand

Proteins
for MYH4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MYH4_HUMAN, Q9Y623 (See protein sequence)
Recommended Name: Myosin-4  
Size: 1939 amino acids; 223071 Da
Subunit: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain
subunits (MLC) and 2 regulatory light chain subunits (MLC-2)
Subcellular location: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils
Caution: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-4 (MYO4)

Explore the universe of human proteins at neXtProt for MYH4: NX_Q9Y623

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y623

    • MYH4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060003.2  
    ENSEMBL proteins: 
     ENSP00000255381  
    Reactome Protein details: Q9Y623
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MYH4

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005859muscle myosin complex NAS3904738
    GO:0005925focal adhesion IDA--
    GO:0030016myofibril IDA8145163


    MYH4 for ontologies           About GeneDecksing



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    Uscn Antibodies for MYH4
    Search ThermoFisher Antibodies for MYH4

    Assay Products for MYH4: 
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    Uscn ELISAs and CLIAs for MYH4

    Protein Domains /
    Families
    for MYH4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MYH4 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR004009 Myosin_N
     IPR000048 IQ_motif_EF-hand-BS
     IPR002928 Myosin_tail
     IPR015650 Myosin_1/23/4/7/8/13/15
     IPR001609 Myosin_head_motor_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y623

    ProtoNet protein and cluster: Q9Y623

    3 Blocks protein families:
    IPB000048 IQ calmodulin-binding region
    IPB002928 Myosin tail
    IPB004009 Myosin N-terminal SH3-like domain


    UniProtKB/Swiss-Prot: MYH4_HUMAN, Q9Y623
    Domain: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4
    heptapeptides, characteristic for alpha-helical coiled coils
    Domain: Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later
    be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2)
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 myosin head-like domain


    Function
    for MYH4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MYH4_HUMAN, Q9Y623
    Function: Muscle contraction

         Genatlas biochemistry entry for MYH4:
    myosin,motor contractile protein moving towards the "plus" end of actin track,heavy polypeptide 4,200kDa,skeletal
    muscle

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYH4
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate MYH4:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: MYH4
    OriGene siRNA: MYH4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYH4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MYH4

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYH4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYH4
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYH4 

    Cell Line
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    Search LifeMap BioReagents cell lines for MYH4

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000146microfilament motor activity NAS10388558
    GO:0003779actin binding IEA--
    GO:0005516calmodulin binding IEA--
    GO:0005524ATP binding IEA--
    GO:0008307structural constituent of muscle NAS3904738


    MYH4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Myh4tm1Lnwd for MYH4
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Myh4):
     behavior/neurological  growth/size  immune system  muscle 

    MYH4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MYH4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_Integrin-mediated cell adhesion and migration
    		Cell adhesion_Integrin-mediated cell adhesion and migration1.00
    		Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    		Cell adhesion Integrin-mediated cell adhesion and migration1.00
    		Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases0.49
    2Immune response _CCR3 signaling in eosinophils
    		Immune response _CCR3 signaling in eosinophils1.00
    		Inhibitory action of Lipoxins on neutrophil migration0.51
    		Immune response CCR3 signaling in eosinophils1.00
    3PAK Pathway
    		PAK Pathway1.00
    		Epithelial Adherens Junctions0.36
    		Antioxidant Action of Vitamin-C0.56
    4Membrane Trafficking
    		Membrane Trafficking1.00
    		Translocation of GLUT4 to the Plasma Membrane0.32
    5Cell adhesion Tight junctions
    		Cell adhesion Tight junctions1.00
    		Cell adhesion_Tight junctions0.99

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 EMD Millipore Pathways for MYH4
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils
    Development MAG-dependent inhibition of neurite outgrowth

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYH4 (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions

    5/6 GeneGo (Thomson Reuters) Pathways for MYH4 (see all 6)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Tight junctions

    3        Reactome Pathways for MYH4
        Membrane Trafficking
    Translocation of GLUT4 to the Plasma Membrane
    Translocation of GLUT4 Vesicle and Docking at the Plasma Membrane


    2         Kegg Pathways  (Kegg details for MYH4):
        Tight junction
    Viral myocarditis


    MYH4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYH4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for MYH4 (Q9Y6233 ENSP000002553814) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    NTHL1P785493, ENSP000002190664I2D: score=1 STRING: ENSP00000219066
    S100A4P264473, ENSP000003462944I2D: score=1 STRING: ENSP00000346294
    USP15Q9Y4E83, ENSP000002581234I2D: score=2 STRING: ENSP00000258123
    C12orf44Q9BSB43, ENSP000003389904I2D: score=3 STRING: ENSP00000338990
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction IDA8145163
    GO:0014823response to activity IEA--
    GO:0030048actin filament-based movement NAS10388558
    GO:0030049muscle filament sliding NAS3904738


    MYH4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MYH4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MYH4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (R)-(+)-BlebbistatinSelective inhibitor of myosin II. Inactive enantiomer of (±)-blebbistatin (Cat. No. 1760)--
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II. Active enantiomer of (±)-blebbistatin (Cat. No. 1760)[856925-71-8]
    (±)-BlebbistatinSelective inhibitor of myosin II[674289-55-5]
    Search CenterWatch for drugs/clinical trials and news about MYH4 

    Transcripts
    for MYH4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MYH4 gene: 
    NM_017533.2  

    Unigene Cluster for MYH4:

    Myosin, heavy chain 4, skeletal muscle
    Hs.711141
    Unigene Representative Sequence: AF111783
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000255381(uc002gmn.3)

    miRNA
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    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: AF111783.2 

    2 DOTS entries:

    DT.100797154  DT.95134937 

    24/360 AceView cDNA sequences (see all 360):

    F27373 F36130 AA196858 F35608 F25815 F29771 AA192637 BX500391 
    F34834 AA194327 F28298 AA197171 BC022376 F18149 F16647 F23374 
    AA180982 AA192839 F18911 CF553036 BM716583 F26552 F28725 F24623 

    GeneLoc Exon Structure


    Expression
    for MYH4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYH4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAGAAGAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MYH4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/21 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 21) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMultinuclear MyocytesSkeletal Muscle
    LimbForelimb Dorsal MusclesMultinuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMultinuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMultinuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleAnterior Neck MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleCervical Back MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleLumbar Back MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleLumbar Vertebrae Column MusclesMultinuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MYH4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYH4

    SOURCE GeneReport for Unigene cluster: Hs.711141
        SABiosciences Custom PCR Arrays for MYH4
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH4

    Orthologs
    for MYH4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MYH4 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MYH36
    MYH16
    (see all 7)    		 muscle embryonic myosin heavy chain 3
    (see all 7)    		 92(a)
    91(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 18(17-7186)
    18(384589-401517)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 90(a)
    		 1 → many
    		 2(109026006-109052169)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC041716.12   -- 79.79(n)    BC041716.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:661561 zgc:66156 77.45(n)
    83.77(a)    		   393472  XM_002666095.2  XP_002666141.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Mhc3 striated muscle contraction myosin ATPase 50(a)
    (best of 2)    		   2 36B1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea F58G4.13 myosin 48(a)
    (best of 4)    		   V(8111649-8120439)   --


    ENSEMBL Gene Tree for MYH4 (if available)
    TreeFam Gene Tree for MYH4 (if available) 

    Paralogs
    for MYH4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYH4 gene
    MYH82  MYH12  MYH22  MYH112  MYH142  MYH92  MYH132  MYH102  
    MYH7B2  MYH32  MYH62  MYH152  MYH72  
    14 SIMAP similar genes for MYH4 using alignment to 1 protein entry:     MYH4_HUMAN:
    MYH8    MYH2    MYH13    MYH3    MYH1    MYH6
    MYH7    MYH7B    MYH15    MYH16    MYH9    MYH10
    MYH11    MYH14

    MYH4 for paralogs           About GeneDecksing



    Genomic Variants
    for MYH4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/629 NCBI SNPs in MYH4 are shown (see all 629)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1473960841,2
    		--10346185(+) GCAGCC/TCACTC 1 -- ds50010--------
    rs1381448611,2
    		--10346330(+) CTTTCA/GTGTCC 1 -- ds50010--------
    rs169434271,2
    		C,F,--10346366(+) TACTCA/CGTAAA 1 -- ds50014Minor allele frequency- C:0.03NA WA 260
    rs169434311,2
    		C,F,--10346396(+) GAGTGC/TGTTTG 1 -- ds50014Minor allele frequency- T:0.03NA WA 260
    rs1893710661,2
    		--10346534(+) AGGAAG/TTAGTT 1 -- ds50010--------
    rs2007892491,2
    		--10346712(+) GACTTC/TTGTGT 2 K E mis10--------
    rs1511250831,2
    		C,F--10346774(+) CAGCCC/TGTTCC 2 Q R mis11Minor allele frequency- T:0.00NA 4550
    rs1410917431,2
    		C,F--10346775(+) AGCCCG/ATTCCT 2 /R /W mis11Minor allele frequency- A:0.00NA 4550
    rs37445541,2
    		C,F,A,H,--10346781(+) TTCCTT/CGGCCT 2 /K /E mis120Minor allele frequency- C:0.45EA NS NA WA CSA EU 7444
    rs1999449541,2
    		--10346797(+) AGCTCA/GTGCTG 2 H syn10--------

    HapMap Linkage Disequilibrium report for MYH4 (10346607 - 10372876 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MYH4: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for MYH4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MYH4 for disorders           About GeneDecksing

    OMIM gene information: 160742    OMIM disorders: --

    7 diseases for MYH4:    About MalaCards
    congestive heart failure    yaws    myocarditis    hermaphroditism
    liver disease    pharyngitis    alcoholism

    1 Novoseek disease relationship for MYH4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heart failure 14.9 1 9054750 (1)

    Human Genome Epidemiology (HuGE) Navigator: MYH4 (4 documents)

    Export disorders for MYH4 gene to outside databases

    Publications
    for MYH4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYH4 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with MYH4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity. (PubMed id 10388558)1, 2 Weiss A.... Leinwand L.A. (1999)
    2. Five skeletal myosin heavy chain genes are organized as a multigene complex in the human genome. (PubMed id 8518795)1, 3 Soussi-Yanicostas N....Petit C. (1993)
    3. Abundant expression of myosin heavy-chain IIB RNA in a subset of human masseter muscle fibres. (PubMed id 11543711)1, 9 Horton M.J....Sciote J.J. (2001)
    4. Temporal spatial expression and function of non-muscl e myosin II isoforms IIA and IIB in scar remodeling. (PubMed id 21102503)1 Bond J.E....Levinson H. (2011)
    5. Defining potentially conserved RNA regulons of homolo gous zinc-finger RNA-binding proteins. (PubMed id 21232131)1 Scherrer T....Gerber A.P. (2011)
    6. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    8. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    9. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    External Searches for MYH4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing MYH4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4622 HGNC: 7574 AceView: MYH1andMYH4andMYH2 Ensembl:ENSG00000264424 euGenes: HUgn4622
    ECgene: MYH4 Kegg: 4622 H-InvDB: MYH4

    Other Databases showing MYH4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MYH4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYH4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MYH4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MYH4 gene:
    Search GeneIP for patents involving MYH4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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