Aliases for MYH4 Gene
External Ids for MYH4 Gene
Previous GeneCards Identifiers for MYH4 Gene
GeneCards Summary for MYH4 Gene
MYH4 (Myosin, Heavy Chain 4, Skeletal Muscle) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and ERK Signaling. GO annotations related to this gene include actin binding and structural constituent of muscle. An important paralog of this gene is MYH1.
UniProtKB/Swiss-Prot for MYH4 Gene
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name), almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II. Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by intracellular Ca2+ concentrations.