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MYH4 Gene

protein-coding   GIFtS: 60
GCID: GC17M010346

Myosin, Heavy Chain 4, Skeletal Muscle

(Previous names: myosin, heavy polypeptide 4, skeletal muscle)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin, Heavy Chain 4, Skeletal Muscle1 2     MyHC-IIb2 3
Myosin, Heavy Polypeptide 4, Skeletal Muscle1 2     MYH2B2
Myosin Heavy Chain 2b2 3     MyHC-2B2
Myosin Heavy Chain 42 3     myosin-42
Myosin Heavy Chain IIb2 3     MyHC-2b3
Myosin Heavy Chain, Skeletal Muscle, Fetal2 3     

External Ids:    HGNC: 75741   Entrez Gene: 46222   Ensembl: ENSG000002644247   OMIM: 1607425   UniProtKB: Q9Y6233   

Export aliases for MYH4 gene to outside databases

Previous GC identifers: GC17M010712 GC17M011461 GC17M010289 GC17M010547 GC17M010287


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYH4 Gene:
MYH4 (myosin, heavy chain 4, skeletal muscle) is a protein-coding gene. Diseases associated with MYH4 include yaws, and congestive heart failure. GO annotations related to this gene include structural constituent of muscle and actin binding. An important paralog of this gene is MYH8.

UniProtKB/Swiss-Prot: MYH4_HUMAN, Q9Y623
Function: Muscle contraction

summary for MYH4 Gene:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYH4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MYH4 gene promoter:
         SRF   TBP   AML1a   SRF (504 AA)   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   C/EBPalpha   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYH4 promoter sequence
   Search Chromatin IP Primers for MYH4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYH4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

MYH4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYH4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M010346:  view genomic region     (about GC identifiers)

Start:
10,346,607 bp from pter      End:
10,372,876 bp from pter
Size:
26,270 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MYH4_HUMAN, Q9Y623 (See protein sequence)
Recommended Name: Myosin-4  
Size: 1939 amino acids; 223071 Da
Subunit: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain
subunits (MLC) and 2 regulatory light chain subunits (MLC-2)
Caution: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-4
(MYO4)

Explore the universe of human proteins at neXtProt for MYH4: NX_Q9Y623

Explore proteomics data for MYH4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1813
  • Modification sites at PhosphoSitePlus

  • See MYH4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060003.2  
    ENSEMBL proteins: 
     ENSP00000255381  
    Reactome Protein details: Q9Y623

    MYH4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MYHII: Myosins / Myosin superfamily : Class II

    Selected InterPro protein domains (see all 7):
     IPR027401 Myosin-like_IQ_dom
     IPR015650 Myosin_1/23/4/6/7/8/13/15
     IPR004009 Myosin_N
     IPR027417 P-loop_NTPase
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry Q9Y623

    ProtoNet protein and cluster: Q9Y623

    3 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB002928 Myosin tail
    IPB004009 Myosin N-terminal SH3-like domain


    UniProtKB/Swiss-Prot: MYH4_HUMAN, Q9Y623
    Domain: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of
    4 heptapeptides, characteristic for alpha-helical coiled coils
    Domain: Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can
    later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2)
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 myosin head-like domain


    MYH4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYH4_HUMAN, Q9Y623
    Function: Muscle contraction

         Genatlas biochemistry entry for MYH4:
    myosin,motor contractile protein moving towards the "plus" end of actin track,heavy polypeptide 4,200kDa,skeletal
    muscle

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000146microfilament motor activity NAS10388558
    GO:0000166nucleotide binding ----
    GO:0003725double-stranded RNA binding IDA--
    GO:0003774motor activity ----
    GO:0003779actin binding IEA--
         
    MYH4 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Myh4):
     behavior/neurological  growth/size/body  immune system  muscle 

    MYH4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Myh4tm1Lnwd for MYH4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYH4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYH4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYH4

    miRNA
    Products:
        
    miRTarBase miRNAs that target MYH4:
    hsa-mir-23a-3p (MIRT006909)

    Block miRNA regulation of human, mouse, rat MYH4 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate MYH4:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MYH4

    Gene Editing
    Products:
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    Clone
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    OriGene ORF clones in mouse, rat for MYH4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYH4 (NM_017533)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYH4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYH4

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYH4_HUMAN, Q9Y623: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    nucleus4
    cytosol3
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005730nucleolus ----
    GO:0005859muscle myosin complex NAS3904738
    GO:0005925focal adhesion ----
    GO:0016459myosin complex ----

    MYH4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYH4 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    2Cell adhesion Integrin mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Development MAG dependent inhibition of neurite outgrowth0.46
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cell adhesion Tight junctions0.33
    3PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35
    5RhoGDI Pathway
    Fc-GammaR-Mediated Phagocytosis in Macrophages0.33
    RhoGDI Pathway0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYH4 (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions

    Selected GeneGo (Thomson Reuters) Pathways for MYH4 (see all 6)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Tight junctions

    1 Reactome Pathway for MYH4
        Translocation of GLUT4 to the plasma membrane


    1 Kegg Pathway  (Kegg details for MYH4):
        Tight junction


    MYH4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYH4
    Interactions:

        Search GeneGlobe Interaction Network for MYH4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYH4 (Q9Y6233 ENSP000002553814) via UniProtKB, MINT, STRING, and/or I2D (see all 134)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP15Q9Y4E83, ENSP000002581234I2D: score=2 STRING: ENSP00000258123
    NTHL1P785493, ENSP000002190664I2D: score=1 STRING: ENSP00000219066
    S100A4P264473, ENSP000003462944I2D: score=1 STRING: ENSP00000346294
    ATG101Q9BSB43, ENSP000003389904I2D: score=3 STRING: ENSP00000338990
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process NAS10388558
    GO:0006936muscle contraction IDA8145163
    GO:0014823response to activity IEA--
    GO:0030048actin filament-based movement NAS10388558
    GO:0030049muscle filament sliding NAS3904738

    MYH4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MYH4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BTSSelective inhibitor of skeletal muscle myosin II ATPase activity[1576-37-0]
    (R)-(+)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)[1177356-70-5]
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)[856925-71-8]
    (+-)-BlebbistatinSelective inhibitor of myosin II ATPase activity[674289-55-5]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MYH4 gene: 
    NM_017533.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000255381(uc002gmn.3)
    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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      QuantiFast Probe-based Assays in human, mouse, rat MYH4

    Selected AceView cDNA sequences (see all 360):

    F24623 AF111784 F32753 BU738138 CF552962 F18618 F29611 AA197171 
    F27373 AA196858 F32013 F17405 AJ573934 F34834 CF553036 BX500391 
    F36197 F17086 F26552 F16303 F21722 AL042515 F35608 AA192637 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYH4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGAAGAGT
    MYH4 Expression
    About this image


    MYH4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 16 entries
             Multinuclear Myocytes Mandibular Arch Muscles
     
     Limb (Muscoskeletal System)    fully expand to see all 7 entries
             Multinuclear Myocytes Forelimb Dorsal Muscles
             Autopod
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Long Bone
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
    MYH4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYH4 Protein Expression
        Custom PCR Arrays for MYH4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MYH4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myh41 , 5 myosin, heavy polypeptide 4, skeletal muscle1, 5 89.72(n)1
    95.62(a)1
      11 (40.59 cM)5
    178841  NM_010855.31  NP_034985.21 
     672380295 
    chicken
    (Gallus gallus)
    Aves MYH1E6
    Gallus gallus myosin, heavy chain 6, cardiac muscl...
    90(a)
    many ↔ many
    18(538724-561401)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041716.12   -- 79.79(n)    BC041716.1 
    zebrafish
    (Danio rerio)
    Actinopterygii myhb1 myosin, heavy chain b 76.35(n)
    83.56(a)
      100002040  XM_001339170.5  XP_001339206.5 


    ENSEMBL Gene Tree for MYH4 (if available)
    TreeFam Gene Tree for MYH4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYH4 gene
    MYH82  MYH12  MYH22  MYH112  MYH142  MYH92  MYH102  MYH132  
    MYH7B2  MYH32  MYH152  MYH62  MYH72  
    14 SIMAP similar genes for MYH4 using alignment to 1 protein entry:     MYH4_HUMAN:
    MYH8    MYH2    MYH13    MYH3    MYH1    MYH6
    MYH7    MYH7B    MYH15    MYH16    MYH9    MYH10
    MYH11    MYH14

    MYH4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYH4 (see all 852)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1473960841,2
    C--10346185(+) GCAGCC/TCACTC 1 -- ds50010--------
    rs1381448611,2
    --10346330(+) CTTTCA/GTGTCC 1 -- ds50010--------
    rs169434271,2
    C,F--10346366(+) TACTCA/CGTAAA 1 -- ds50014Minor allele frequency- C:0.03NA WA 260
    rs169434311,2
    C,F--10346396(+) GAGTGC/TGTTTG 1 -- ds50014Minor allele frequency- T:0.03NA WA 260
    rs1893710661,2
    --10346534(+) AGGAAG/TTAGTT 1 -- ds50010--------
    rs2007892491,2
    --10346712(+) GACTTC/TTGTGT 2 K E mis10--------
    rs1511250831,2
    C,F--10346774(+) CAGCCC/TGTTCC 2 Q R mis11Minor allele frequency- T:0.00NA 4550
    rs1410917431,2
    C,F--10346775(+) AGCCCG/ATTCCT 2 /R /W mis11Minor allele frequency- A:0.00NA 4550
    rs37445541,2,,4
    C,F,A,H--10346781(+) TTCCTT/CGGCCT 2 /K /E mis120Minor allele frequency- C:0.45EA NS NA WA CSA EU 7444
    rs1999449541,2
    --10346797(+) AGCTCA/GTGCTG 2 H syn10--------

    HapMap Linkage Disequilibrium report for MYH4 (10346607 - 10372876 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MYH4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673250CNV Deletion23128226
    nsv907679CNV Gain21882294
    nsv833366CNV Gain17160897
    nsv907673CNV Gain21882294
    nsv520771CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): MYH4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYH4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 160742    OMIM disorders: --

    5 diseases for MYH4:    
    About MalaCards
    yaws    congestive heart failure    myocarditis    liver disease
    cervicitis


    MYH4 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MYH4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heart failure 14.9 1 9054750 (1)

    Genetic Association Database (GAD): MYH4
    Human Genome Epidemiology (HuGE) Navigator: MYH4 (4 documents)

    Export disorders for MYH4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYH4 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with MYH4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    2. Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity. (PubMed id 10388558)1, 2 Weiss A.... Leinwand L.A. (J. Mol. Biol. 1999)
    3. Five skeletal myosin heavy chain genes are organized as a multigene complex in the human genome. (PubMed id 8518795)1, 3 Soussi-Yanicostas N....Petit C. (Hum. Mol. Genet. 1993)
    4. Abundant expression of myosin heavy-chain IIB RNA in a subset of human masseter muscle fibres. (PubMed id 11543711)1, 9 Horton M.J....Sciote J.J. (Arch. Oral Biol. 2001)
    5. Myosin heavy chain-2b transcripts and isoform are expressed in human laryngeal muscles. (PubMed id 23796659)1 Smerdu V. and Cvetko E. (Cells Tissues Organs (Print) 2013)
    6. Temporal spatial expression and function of non-muscle myosin II isoforms IIA and IIB in scar remodeling. (PubMed id 21102503)1 Bond J.E....Levinson H. ( a journal of technical methods and pathology 2011)
    7. Defining potentially conserved RNA regulons of homologous zinc-finger RNA-binding proteins. (PubMed id 21232131)1 Scherrer T....Gerber A.P. (Genome Biol. 2011)
    8. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (Nature 2010)
    9. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    10. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 4622 HGNC: 7574 AceView: MYH1andMYH4andMYH2 Ensembl:ENSG00000264424 euGenes: HUgn4622
    ECgene: MYH4 Kegg: 4622 H-InvDB: MYH4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MYH4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MYH4 gene:
    Search GeneIP for patents involving MYH4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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