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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYH4 Gene

protein-coding   GIFtS: 62
GCID: GC17M010346

Myosin, Heavy Chain 4, Skeletal Muscle

(Previous names: myosin, heavy polypeptide 4, skeletal muscle)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Myosin, Heavy Chain 4, Skeletal Muscle1 2     MyHC-IIb2 3
Myosin, Heavy Polypeptide 4, Skeletal Muscle1 2     MYH2B2
Myosin Heavy Chain 2b2 3     MyHC-2B2
Myosin Heavy Chain 42 3     myosin-42
Myosin Heavy Chain IIb2 3     MyHC-2b3
Myosin Heavy Chain, Skeletal Muscle, Fetal2 3     

External Ids:    HGNC: 75741   Entrez Gene: 46222   Ensembl: ENSG000002644247   OMIM: 1607425   UniProtKB: Q9Y6233   

Export aliases for MYH4 gene to outside databases

Previous GC identifers: GC17M010712 GC17M011461 GC17M010289 GC17M010547 GC17M010287


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MYH4 Gene: 
MYH4 (myosin, heavy chain 4, skeletal muscle) is a protein-coding gene. Diseases associated with MYH4 include yaws, and congestive heart failure, and among its related super-pathways are Immune response CCR3 signaling in eosinophils and Antioxidant Action of Vitamin-C. GO annotations related to this gene include structural constituent of muscle and actin binding. An important paralog of this gene is MYH8.

UniProtKB/Swiss-Prot: MYH4_HUMAN, Q9Y623
Function: Muscle contraction

summary for MYH4 Gene:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYH4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYH4 gene promoter:
         SRF   TBP   AML1a   SRF (504 AA)   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   C/EBPalpha   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYH4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MYH4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYH4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

MYH4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYH4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M010346:  view genomic region     (about GC identifiers)

Start:
10,346,607 bp from pter      End:
10,372,876 bp from pter
Size:
26,270 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MYH4_HUMAN, Q9Y623 (See protein sequence)
Recommended Name: Myosin-4  
Size: 1939 amino acids; 223071 Da
Subunit: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain
subunits (MLC) and 2 regulatory light chain subunits (MLC-2)
Subcellular location: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils
Caution: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-4
(MYO4)

Explore the universe of human proteins at neXtProt for MYH4: NX_Q9Y623

Explore proteomics data for MYH4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y623

  • MYH4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MYH4 Protein Expression
    REFSEQ proteins: NP_060003.2  
    ENSEMBL proteins: 
     ENSP00000255381  
    Reactome Protein details: Q9Y623
    Human Recombinant Protein Products for MYH4: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYH4 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005859muscle myosin complex NAS3904738
    GO:0005925focal adhesion IDA--
    GO:0016459myosin complex ----

    MYH4 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for MYH4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MYHII: Myosins / Myosin superfamily : Class II

    5/7 InterPro protein domains (see all 7):
     IPR027401 Myosin-like_IQ_dom
     IPR015650 Myosin_1/23/4/7/8/13/15
     IPR004009 Myosin_N
     IPR027417 P-loop_NTPase
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry Q9Y623

    ProtoNet protein and cluster: Q9Y623

    3 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB002928 Myosin tail
    IPB004009 Myosin N-terminal SH3-like domain


    UniProtKB/Swiss-Prot: MYH4_HUMAN, Q9Y623
    Domain: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of
    4 heptapeptides, characteristic for alpha-helical coiled coils
    Domain: Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can
    later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2)
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 myosin head-like domain


    MYH4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYH4_HUMAN, Q9Y623
    Function: Muscle contraction

         Genatlas biochemistry entry for MYH4:
    myosin,motor contractile protein moving towards the "plus" end of actin track,heavy polypeptide 4,200kDa,skeletal
    muscle

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000146microfilament motor activity NAS10388558
    GO:0000166nucleotide binding ----
    GO:0003774motor activity ----
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
         
    MYH4 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Myh4):
     behavior/neurological  growth/size  immune system  muscle 

    MYH4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Myh4tm1Lnwd for MYH4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MYH4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MYH4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYH4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYH4 

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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MYH4 About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response CCR3 signaling in eosinophils
    Immune response CCR3 signaling in eosinophils0.51
    Inhibitory action of Lipoxins on neutrophil migration0.51
    2PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    3Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin-mediated cell adhesion and migration0.49
    Cell adhesion Tight junctions0.33
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35
    5Fc-GammaR-Mediated Phagocytosis in Macrophages
    Fc-GammaR-Mediated Phagocytosis in Macrophages0.33
    RhoGDI Pathway0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for MYH4
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils
    Development MAG-dependent inhibition of neurite outgrowth

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYH4 (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions

    5/6 GeneGo (Thomson Reuters) Pathways for MYH4 (see all 6)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Tight junctions

    2        Reactome Pathways for MYH4
        Membrane Trafficking
    Translocation of GLUT4 to the Plasma Membrane


    2         Kegg Pathways  (Kegg details for MYH4):
        Tight junction
    Viral myocarditis


    MYH4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYH4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for MYH4 (Q9Y6233 ENSP000002553814) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    NTHL1P785493, ENSP000002190664I2D: score=1 STRING: ENSP00000219066
    S100A4P264473, ENSP000003462944I2D: score=1 STRING: ENSP00000346294
    USP15Q9Y4E83, ENSP000002581234I2D: score=2 STRING: ENSP00000258123
    C12orf44Q9BSB43, ENSP000003389904I2D: score=3 STRING: ENSP00000338990
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction IDA8145163
    GO:0014823response to activity IEA--
    GO:0030048actin filament-based movement NAS10388558
    GO:0030049muscle filament sliding NAS3904738

    MYH4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MYH4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BTSSelective inhibitor of skeletal muscle myosin II ATPase activity[1576-37-0]
    (R)-(+)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)[1177356-70-5]
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)[856925-71-8]
    (+-)-BlebbistatinSelective inhibitor of myosin II ATPase activity[674289-55-5]

    Search CenterWatch for drugs/clinical trials and news about MYH4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYH4 gene: 
    NM_017533.2  

    Unigene Cluster for MYH4:

    Myosin, heavy chain 4, skeletal muscle
    Hs.711141
    Unigene Representative Sequence: AF111783
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000255381(uc002gmn.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: AF111783.2 

    2 DOTS entries:

    DT.100797154  DT.95134937 

    24/360 AceView cDNA sequences (see all 360):

    AL042515 F34607 CF553036 CF552962 F18911 AA194327 AA214068 BU738138 
    F32753 F17405 F29611 F26883 F35608 F17086 F16647 F28298 
    AA196858 F25925 F24623 BX500391 AA192637 AA192839 F27834 F25815 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYH4 expression in normal human tissues (normalized intensities)      MYH4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGAAGAGT
    MYH4 Expression
    About this image


    MYH4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 22 entries
             Multinuclear Myocytes Mandibular Arch Muscles
             cavities and their linings/intraembryonic coelom/diaphragm   
     
     Limb (Muscoskeletal System)    fully expand to see all 10 entries
             Multinuclear Myocytes Forelimb Dorsal Muscles
             Autopod
             limb/hindlimb/hind-paw   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Long Bone
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/ventricle   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut

    See MYH4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYH4

    SOURCE GeneReport for Unigene cluster: Hs.711141
        SABiosciences Custom PCR Arrays for MYH4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MYH4 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myh41 , 5 myosin, heavy polypeptide 4, skeletal muscle1, 5 89.72(n)1
    95.62(a)1
      11 (40.59 cM)5
    178841  NM_010855.21  NP_034985.21 
     672380295 
    chicken
    (Gallus gallus)
    Aves MYH26
    MYH16
    (see all 7)
    Uncharacterized protein
    (see all 7)
    91(a)
    91(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    18(473713-638720)
    18(381895-399588)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    90(a)
    90(a)
    many ↔ many
    many ↔ many
    2(109022921-109052169)
    2(108951248-109016986)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041716.12   -- 79.79(n)    BC041716.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:661561 zgc:66156 77.45(n)
    83.77(a)
      393472  XM_002666095.2  XP_002666141.2 


    ENSEMBL Gene Tree for MYH4 (if available)
    TreeFam Gene Tree for MYH4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYH4 gene
    MYH82  MYH12  MYH22  MYH112  MYH142  MYH92  MYH102  MYH132  
    MYH7B2  MYH32  MYH152  MYH62  MYH72  
    14 SIMAP similar genes for MYH4 using alignment to 1 protein entry:     MYH4_HUMAN:
    MYH8    MYH2    MYH13    MYH3    MYH1    MYH6
    MYH7    MYH7B    MYH15    MYH16    MYH9    MYH10
    MYH11    MYH14

    MYH4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/852 SNPs in MYH4 are shown (see all 852)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1473960841,2
    C--10346185(+) GCAGCC/TCACTC 1 -- ds50010--------
    rs1381448611,2
    --10346330(+) CTTTCA/GTGTCC 1 -- ds50010--------
    rs169434271,2
    C,F--10346366(+) TACTCA/CGTAAA 1 -- ds50014Minor allele frequency- C:0.03NA WA 260
    rs169434311,2
    C,F--10346396(+) GAGTGC/TGTTTG 1 -- ds50014Minor allele frequency- T:0.03NA WA 260
    rs1893710661,2
    --10346534(+) AGGAAG/TTAGTT 1 -- ds50010--------
    rs2007892491,2
    --10346712(+) GACTTC/TTGTGT 2 K E mis10--------
    rs1511250831,2
    C,F--10346774(+) CAGCCC/TGTTCC 2 Q R mis11Minor allele frequency- T:0.00NA 4550
    rs1410917431,2
    C,F--10346775(+) AGCCCG/ATTCCT 2 /R /W mis11Minor allele frequency- A:0.00NA 4550
    rs37445541,2,4
    C,F,A,H--10346781(+) TTCCTT/CGGCCT 2 /K /E mis120Minor allele frequency- C:0.45EA NS NA WA CSA EU 7444
    rs1999449541,2
    --10346797(+) AGCTCA/GTGCTG 2 H syn10--------

    HapMap Linkage Disequilibrium report for MYH4 (10346607 - 10372876 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MYH4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2673250CNV Deletion23128226
    nsv907679CNV Gain21882294
    nsv833366CNV Gain17160897
    nsv907673CNV Gain21882294
    nsv520771CNV Gain+Loss19592680


    Human Gene Mutation Database (HGMD): MYH4
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MYH4
    DNA2.0 Custom Variant and Variant Library Synthesis for MYH4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 160742    OMIM disorders: --

    5 diseases for MYH4:    About MalaCards
    yaws    congestive heart failure    myocarditis    liver disease
    alcoholism


    MYH4 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MYH4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heart failure 14.9 1 9054750 (1)

    Genetic Association Database (GAD): MYH4
    Human Genome Epidemiology (HuGE) Navigator: MYH4 (4 documents)

    Export disorders for MYH4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYH4 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with MYH4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    2. Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity. (PubMed id 10388558)1, 2 Weiss A.... Leinwand L.A. (1999)
    3. Five skeletal myosin heavy chain genes are organized as a multigene complex in the human genome. (PubMed id 8518795)1, 3 Soussi-Yanicostas N....Petit C. (1993)
    4. Abundant expression of myosin heavy-chain IIB RNA in a subset of human masseter muscle fibres. (PubMed id 11543711)1, 9 Horton M.J....Sciote J.J. (2001)
    5. Temporal spatial expression and function of non-muscl e myosin II isoforms IIA and IIB in scar remodeling. (PubMed id 21102503)1 Bond J.E....Levinson H. (2011)
    6. Defining potentially conserved RNA regulons of homolo gous zinc-finger RNA-binding proteins. (PubMed id 21232131)1 Scherrer T....Gerber A.P. (2011)
    7. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
    8. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    9. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4622 HGNC: 7574 AceView: MYH1andMYH4andMYH2 Ensembl:ENSG00000264424 euGenes: HUgn4622
    ECgene: MYH4 Kegg: 4622 H-InvDB: MYH4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYH4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYH4 gene:
    Search GeneIP for patents involving MYH4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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