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Aliases for MYH4 Gene

Aliases for MYH4 Gene

  • Myosin, Heavy Chain 4, Skeletal Muscle 2 3
  • Myosin, Heavy Polypeptide 4, Skeletal Muscle 2 3
  • Myosin Heavy Chain, Skeletal Muscle, Fetal 3 4
  • Myosin Heavy Chain IIb 3 4
  • Myosin Heavy Chain 2b 3 4
  • Myosin Heavy Chain 4 3 4
  • MyHC-IIb 3 4
  • MyHC-2B 3 4
  • Myosin-4 3
  • MYH2B 3

External Ids for MYH4 Gene

Previous GeneCards Identifiers for MYH4 Gene

  • GC17M010712
  • GC17M011461
  • GC17M010289
  • GC17M010547
  • GC17M010287

Summaries for MYH4 Gene

GeneCards Summary for MYH4 Gene

MYH4 (Myosin, Heavy Chain 4, Skeletal Muscle) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and ERK Signaling. GO annotations related to this gene include actin binding and structural constituent of muscle. An important paralog of this gene is MYH1.

UniProtKB/Swiss-Prot for MYH4 Gene

  • Muscle contraction

Tocris Summary for MYH4 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name), almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II. Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by intracellular Ca2+ concentrations.

Gene Wiki entry for MYH4 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYH4 Gene

Genomics for MYH4 Gene

Genomic Location for MYH4 Gene

10,443,290 bp from pter
10,469,559 bp from pter
26,270 bases
Minus strand

Genomic View for MYH4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYH4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYH4 Gene

Proteins for MYH4 Gene

  • Protein details for MYH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:

    Protein attributes for MYH4 Gene

    1939 amino acids
    Molecular mass:
    223071 Da
    Quaternary structure:
    • Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2)

neXtProt entry for MYH4 Gene

Proteomics data for MYH4 Gene at MOPED

Post-translational modifications for MYH4 Gene

  • Ubiquitination at Lys1813
  • Modification sites at PhosphoSitePlus

Other Protein References for MYH4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MYH4 Gene

Domains for MYH4 Gene

Gene Families for MYH4 Gene

  • MYHII :Myosins / Myosin superfamily : Class II

Suggested Antigen Peptide Sequences for MYH4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9Y623
  • The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils
  • Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2)
  • Contains 1 IQ domain.
  • Contains 1 myosin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYH4: view

Function for MYH4 Gene

Molecular function for MYH4 Gene

GENATLAS Biochemistry:
myosin,motor contractile protein moving towards the "plus" end of actin track,heavy polypeptide 4,200kDa,skeletal muscle
UniProtKB/Swiss-Prot Function:
Muscle contraction

Gene Ontology (GO) - Molecular Function for MYH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000146 microfilament motor activity NAS 10388558
GO:0000166 nucleotide binding --
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0003774 motor activity --
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with MYH4: view
genes like me logo Genes that share phenotypes with MYH4: view

Animal Models for MYH4 Gene

MGI Knock Outs for MYH4:

Animal Model Products

miRNA for MYH4 Gene

miRTarBase miRNAs that target MYH4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYH4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MYH4 Gene

Localization for MYH4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYH4 Gene

Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.

Subcellular locations from

Jensen Localization Image for MYH4 Gene COMPARTMENTS Subcellular localization image for MYH4 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MYH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005859 muscle myosin complex NAS 3904738
GO:0016459 myosin complex --
GO:0030016 myofibril IDA 8145163
GO:0030017 sarcomere NAS 3904738
GO:0032982 myosin filament IEA --
genes like me logo Genes that share ontologies with MYH4: view

Pathways for MYH4 Gene

genes like me logo Genes that share pathways with MYH4: view

Gene Ontology (GO) - Biological Process for MYH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006936 muscle contraction IDA 8145163
GO:0008152 metabolic process NAS 10388558
GO:0014823 response to activity IEA --
GO:0030048 actin filament-based movement NAS 10388558
genes like me logo Genes that share ontologies with MYH4: view

Compounds for MYH4 Gene

(4) Tocris Compounds for MYH4 Gene

Compound Action Cas Number
(�)-Blebbistatin Selective inhibitor of myosin II ATPase activity [674289-55-5]
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (�)-blebbistatin (Cat. No. 1760) [1177356-70-5]
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (�)-blebbistatin (Cat. No. 1760) [856925-71-8]
BTS Selective inhibitor of skeletal muscle myosin II ATPase activity [1576-37-0]
genes like me logo Genes that share compounds with MYH4: view

Transcripts for MYH4 Gene

mRNA/cDNA for MYH4 Gene

(360) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYH4 Gene

Myosin, heavy chain 4, skeletal muscle:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYH4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYH4 Gene

No ASD Table

Relevant External Links for MYH4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYH4 Gene

mRNA expression in normal human tissues for MYH4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYH4 Gene

This gene is overexpressed in Muscle - Skeletal (41.4) and Liver (4.3).

Protein differential expression in normal tissues for MYH4 Gene

This gene is overexpressed in Esophagus (21.7), Heart (15.6), and Adrenal (10.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYH4 Gene

SOURCE GeneReport for Unigene cluster for MYH4 Gene Hs.711141

genes like me logo Genes that share expressions with MYH4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for MYH4 Gene

Orthologs for MYH4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYH4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MYH4 35
  • 91.21 (n)
  • 95.25 (a)
MYH4 36
  • 95 (a)
(Canis familiaris)
Mammalia MYH4 35
  • 90.91 (n)
  • 95.36 (a)
MYH4 36
  • 95 (a)
(Mus musculus)
Mammalia Myh4 35
  • 89.72 (n)
  • 95.62 (a)
Myh4 16
Myh4 36
  • 96 (a)
(Pan troglodytes)
Mammalia MYH4 35
  • 99.23 (n)
  • 99.12 (a)
MYH4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Myh4 35
  • 89.94 (n)
  • 95.77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
-- 36
  • 86 (a)
-- 36
  • 94 (a)
(Gallus gallus)
Aves MYH1E 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia myh3 35
  • 79.05 (n)
  • 87.29 (a)
Str.17081 35
(Danio rerio)
Actinopterygii myhb 35
  • 76.35 (n)
  • 83.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mhc 37
  • 50 (a)
Prm 37
  • 34 (a)
(Caenorhabditis elegans)
Secernentea F45G2.2 37
  • 45 (a)
F58G4.1 37
  • 48 (a)
myo-3 37
  • 47 (a)
Y11D7A.14 37
  • 29 (a)
Species with no ortholog for MYH4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYH4 Gene

Gene Tree for MYH4 (if available)
Gene Tree for MYH4 (if available)

Paralogs for MYH4 Gene

Paralogs for MYH4 Gene

Selected SIMAP similar genes for MYH4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MYH4: view

Variants for MYH4 Gene

Sequence variations from dbSNP and Humsavar for MYH4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_022110 -
VAR_024542 -
VAR_030198 -
VAR_030199 -
VAR_030200 -

Structural Variations from Database of Genomic Variants (DGV) for MYH4 Gene

Variant ID Type Subtype PubMed ID
nsv907673 CNV Gain 21882294
nsv520771 CNV Gain+Loss 19592680
nsv907679 CNV Gain 21882294
nsv833366 CNV Gain 17160897
esv2673250 CNV Deletion 23128226

Relevant External Links for MYH4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYH4 Gene

Disorders for MYH4 Gene

(1) Novoseek inferred disease relationships for MYH4 Gene

Disease -log(P) Hits PubMed IDs
heart failure 14.9 1

Relevant External Links for MYH4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MYH4: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for MYH4 Gene

Publications for MYH4 Gene

  1. Abundant expression of myosin heavy-chain IIB RNA in a subset of human masseter muscle fibres. (PMID: 11543711) Horton M.J. … Sciote J.J. (Arch. Oral Biol. 2001) 3 23
  2. Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity. (PMID: 10388558) Weiss A. … Leinwand L.A. (J. Mol. Biol. 1999) 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  4. Five skeletal myosin heavy chain genes are organized as a multigene complex in the human genome. (PMID: 8518795) Soussi-Yanicostas N. … Petit C. (Hum. Mol. Genet. 1993) 2 3
  5. Effect of Mts1 on the structure and activity of nonmuscle myosin II. (PMID: 9405067) Ford H.L. … Zain S.B. (Biochemistry 1997) 3

Products for MYH4 Gene

Sources for MYH4 Gene

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