Aliases for MYH3 Gene
- Myosin, Heavy Chain 3, Skeletal Muscle, Embryonic 2 3
- Myosin, Heavy Polypeptide 3, Skeletal Muscle, Embryonic 2 3
- Myosin Heavy Chain, Fast Skeletal Muscle, Embryonic 3 4
- SMHCE 3 4
- Myosin, Skeletal, Heavy Chain, Embryonic 1 3
- Muscle Embryonic Myosin Heavy Chain 3 2
- Muscle Embryonic Myosin Heavy Chain 4
- Myosin Heavy Chain 3 4
- Heavy Chain 2
External Ids for MYH3 Gene
Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for MYH3 Gene
MYH3 (Myosin, Heavy Chain 3, Skeletal Muscle, Embryonic) is a Protein Coding gene. Diseases associated with MYH3 include pleomorphic rhabdomyosarcoma and arthrogryposis, distal, type 2b. Among its related pathways are RhoGDI Pathway and ERK Signaling. GO annotations related to this gene include actin binding and microfilament motor activity. An important paralog of this gene is MYH4.
UniProtKB/Swiss-Prot for MYH3 Gene
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name), almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II. Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by intracellular Ca2+ concentrations.