Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MYH3 Gene

protein-coding   GIFtS: 63
GCID: GC17M010472

Myosin, Heavy Chain 3, Skeletal Muscle, Embryonic

(Previous names: myosin, heavy polypeptide 3, skeletal muscle, embryonic)
  See MYH3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Myosin, Heavy Chain 3, Skeletal Muscle, Embryonic1 2     skeletal1
Myosin, Heavy Polypeptide 3, Skeletal Muscle, Embryonic1 2     HEMHC2
Myosin Heavy Chain, Fast Skeletal Muscle, Embryonic2 3     MYHC-EMB2
SMHCE2 3     MYHSE12
Embryonic 11     Myosin, Skeletal, Heavy Chain, Embryonic 12
Heavy Chain1     myosin-32
Muscle Embryonic Myosin Heavy Chain 31     Muscle Embryonic Myosin Heavy Chain3
myosin1     Myosin Heavy Chain 33

External Ids:    HGNC: 75731   Entrez Gene: 46212   Ensembl: ENSG000001090637   OMIM: 1607205   UniProtKB: P110553   

Export aliases for MYH3 gene to outside databases

Previous GC identifers: GC17M010897 GC17M011646 GC17M010474 GC17M010732


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MYH3 Gene:
Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis
of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of
nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a
myosin head-like domain. Mutations in this gene have been associated with two congenital contracture
(arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. (provided by RefSeq, Jul 2008)

GeneCards Summary for MYH3 Gene:
MYH3 (myosin, heavy chain 3, skeletal muscle, embryonic) is a protein-coding gene. Diseases associated with MYH3 include myh3-related arthrogryposis multiplex congenita, distal, type 2b, and pleomorphic rhabdomyosarcoma. GO annotations related to this gene include microfilament motor activity and actin binding. An important paralog of this gene is MYH8.

UniProtKB/Swiss-Prot: MYH3_HUMAN, P11055
Function: Muscle contraction

summary for MYH3 Gene:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYH3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYH3 gene promoter:
         AP-2rep   C/EBPbeta   AML1a   Pax-2   MyoD   Pax-2a   Ik-3   RORalpha2   Pax-3   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MYH3 promoter sequence
   Search Chromatin IP Primers for MYH3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

MYH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYH3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M010472:  view genomic region     (about GC identifiers)

Start:
10,531,843 bp from pter      End:
10,560,626 bp from pter
Size:
28,784 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MYH3_HUMAN, P11055 (See protein sequence)
Recommended Name: Myosin-3  
Size: 1940 amino acids; 223905 Da
Subunit: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain
subunits (MLC) and 2 regulatory light chain subunits (MLC-2)
Developmental stage: Abundantly present in fetal skeletal muscle and not present or barely detectable in heart and
adult skeletal muscle
Caution: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-3
(MYO3)
Secondary accessions: Q15492

Explore the universe of human proteins at neXtProt for MYH3: NX_P11055

Explore proteomics data for MYH3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYH3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002461.2  
    ENSEMBL proteins: 
     ENSP00000464317   ENSP00000226209  
    Reactome Protein details: P11055

    MYH3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MYH3
    OriGene Protein Over-expression Lysate for MYH3
    OriGene MassSpec for MYH3
    OriGene Custom Protein Services for MYH3
    GenScript Custom Purified and Recombinant Proteins Services for MYH3
    Novus Biologicals MYH3 Protein
    Novus Biologicals MYH3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYH3

     
    Search eBioscience for Proteins for MYH3 

     
    antibodies-online proteins for MYH3 (4 products) 

     
    Search antibodies-online for peptides for MYH3

    MYH3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MYH3
    Novus Biologicals MYH3 Antibodies
    Abcam antibodies for MYH3 (Q9Y623, P11055, P05976, P60660, P12882)
    Cloud-Clone Corp. Antibodies for MYH3
    Search ThermoFisher Antibodies for MYH3
    antibodies-online antibodies for MYH3 (7 products) 

    MYH3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MYH3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MYH3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MYH3
    Cloud-Clone Corp. CLIAs for MYH3
    Search eBioscience for ELISAs for MYH3 
    antibodies-online kits for MYH3 (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    MYHII: Myosins / Myosin superfamily : Class II

    Selected InterPro protein domains (see all 7):
     IPR027401 Myosin-like_IQ_dom
     IPR015650 Myosin_1/23/4/6/7/8/13/15
     IPR004009 Myosin_N
     IPR027417 P-loop_NTPase
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry P11055

    ProtoNet protein and cluster: P11055

    3 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB002928 Myosin tail
    IPB004009 Myosin N-terminal SH3-like domain


    UniProtKB/Swiss-Prot: MYH3_HUMAN, P11055
    Domain: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of
    4 heptapeptides, characteristic for alpha-helical coiled coils
    Domain: Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can
    later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2)
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 myosin head-like domain


    Find genes that share domains with MYH3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYH3_HUMAN, P11055
    Function: Muscle contraction

         Genatlas biochemistry entry for MYH3:
    myosin,motor contractile protein moving towards the "plus" end of actin track,heavy polypeptide 3,200kDa,skeletal
    muscle,embryonic

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000146microfilament motor activity NAS1691980
    GO:0003774motor activity ----
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
    GO:0005516calmodulin binding NAS16642020
         
    Find genes that share ontologies with MYH3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MYH3:
     High actin ratio cells  Increased cell number in G2M,  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MYH3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MYH3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MYH3:
    hsa-miR-448
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MYH3
    Predesigned siRNA for gene silencing in human, mouse, rat MYH3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MYH3

    Clone
    Products:
         
    OriGene clones in human, mouse for MYH3 (see all 5)
    OriGene ORF clones in mouse, rat for MYH3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYH3 (NM_002470)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYH3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYH3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MYH3
    Browse ESI BIO Cell Lines and PureStem Progenitors for MYH3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MYH3_HUMAN, P11055: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton3
    nucleus2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005859muscle myosin complex NAS16642020
    GO:0016459myosin complex ----
    GO:0030016myofibril ----
    GO:0030017sarcomere NAS16642020

    Find genes that share ontologies with MYH3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MYH3 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Striated Muscle Contraction
    Striated Muscle Contraction0.82
    Muscle contraction0.61
    Striated Muscle Contraction0.82
    2Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    3Cell adhesion Integrin mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Development MAG dependent inhibition of neurite outgrowth0.46
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cell adhesion Tight junctions0.33
    4PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    5Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35


    Find genes that share SuperPaths with MYH3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYH3 (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions

    Selected GeneGo (Thomson Reuters) Pathways for MYH3 (see all 6)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Tight junctions

    1 BioSystems Pathway for MYH3
        Striated Muscle Contraction

    2 Reactome Pathways for MYH3
        Translocation of GLUT4 to the plasma membrane
    Striated Muscle Contraction


    1 Kegg Pathway  (Kegg details for MYH3):
        Tight junction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYH3
    Interactions:

        Search GeneGlobe Interaction Network for MYH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYH3 (P110552, 3 ENSP000002262094) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DESP176612, ENSP000003630714MINT-7899812 STRING: ENSP00000363071
    ACTG1P632612, ENSP000003315144MINT-7899812 STRING: ENSP00000331514
    MYH13Q9UKX32, ENSP000002521724MINT-7899812 STRING: ENSP00000252172
    YWHAZP631042, ENSP000003095034MINT-7899812 STRING: ENSP00000309503
    MLC1Q150493, ENSP000003103754I2D: score=1 STRING: ENSP00000310375
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003009skeletal muscle contraction IMP16642020
    GO:0006200ATP catabolic process IMP16642020
    GO:0007517muscle organ development TAS2771643
    GO:0030048actin filament-based movement NAS1691980
    GO:0030049muscle filament sliding TAS--

    Find genes that share ontologies with MYH3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MYH3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BTSSelective inhibitor of skeletal muscle myosin II ATPase activity[1576-37-0]
    (R)-(+)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)[1177356-70-5]
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)[856925-71-8]
    (+-)-BlebbistatinSelective inhibitor of myosin II ATPase activity[674289-55-5]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MYH3 gene: 
    NM_002470.3  

    Unigene Cluster for MYH3:

    Myosin, heavy chain 3, skeletal muscle, embryonic
    Hs.440895  [show with all ESTs]
    Unigene Representative Sequence: NM_002470
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000579928 ENST00000583535(uc002gmq.2) ENST00000577963 ENST00000579489
    ENST00000582580 ENST00000226209
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MYH3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MYH3:
    hsa-miR-448
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MYH3
    Predesigned siRNA for gene silencing in human, mouse, rat MYH3
    Clone
    Products:
         
    OriGene clones in human, mouse for MYH3 (see all 5)
    OriGene ORF clones in mouse, rat for MYH3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYH3 (NM_002470)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYH3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYH3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MYH3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYH3
      QuantiTect SYBR Green Assays in human, mouse, rat MYH3
      QuantiFast Probe-based Assays in human, mouse, rat MYH3

    Additional mRNA sequence: 

    AY517555.1 X13100.1 X13988.1 X15696.1 X51593.1 

    12 DOTS entries:

    DT.86821382  DT.455514  DT.95267116  DT.121011697  DT.40233316  DT.100020750  DT.100739548  DT.121011604 
    DT.92002345  DT.121011618  DT.95333920  DT.99935319 

    Selected AceView cDNA sequences (see all 68):

    AA010874 AA773676 BQ956249 BM889521 BM874465 BM666179 X51593 NM_002470 
    AI002500 AI243553 X13988 AA913617 CB857848 AI217390 AI266195 AI204351 
    CD614927 BM711088 BM263086 AA332915 AA953585 CD614924 BM717487 AI097012 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MYH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATAAACTT
    MYH3 Expression
    About this image


    MYH3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 6 entries
             Multinuclear Myocytes Mandibular Arch Muscles
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Long Bone
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    MYH3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYH3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.440895
        Custom PCR Arrays for MYH3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MYH3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYH3
    QuantiTect SYBR Green Assays in human, mouse, rat MYH3
    QuantiFast Probe-based Assays in human, mouse, rat MYH3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for MYH3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myh31 , 5 myosin, heavy polypeptide 3, skeletal muscle, embryonic1, 5 89.67(n)1
    98.2(a)1
      11 (40.59 cM)5
    178831  NM_001099635.11  NP_001093105.11 
     670783005 
    chicken
    (Gallus gallus)
    Aves MYH1C6
    MYH1B6
    (see all 3)
    Gallus gallus myosin, heavy chain 1C, skeletal mus...
    Gallus gallus myosin, heavy chain 1B, skeletal mus...
    (see all 3)
    84(a)
    83(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    18(584154-601425)
    18(473713-638720)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    83(a)
    many ↔ many
    2(108951248-109016986)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.120382 Transcribed sequence with moderate similarity to protein more 80.28(n)    BX702799.1 


    ENSEMBL Gene Tree for MYH3 (if available)
    TreeFam Gene Tree for MYH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MYH3 gene
    MYH82  MYH12  MYH22  MYH112  MYH142  MYH92  MYH102  MYH132  
    MYH7B2  MYH42  MYH152  MYH62  MYH72  
    Selected SIMAP similar genes for MYH3 using alignment to 1 protein entry:     MYH3_HUMAN(see all similar genes):
    MYH4    MYH8    MYH13    MYH2    MYH7    MYH6
    MYH1    alpha-MHC    MYH15    MYH7B    MYH16    MYH9
    MYO10    MYH11    MYH10    MYO5B    MYO5C    MYH14

    Find genes that share paralogs with MYH3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MYH3 (see all 1088)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs341654801,2,,4
    C,FArthrogryposis, distal, 2B (DA2B)4 --10525621(-) CCAGGC/TGGCGG 2 A V mis15Minor allele frequency- T:0.00NA EU 5949
    VAR_0303704
    Arthrogryposis, distal, 2B (DA2B)4--see VAR_0303702 T I mis40--------
    VAR_0303834
    Arthrogryposis, distal, 2B (DA2B)4--see VAR_0303832 D A mis40--------
    VAR_0303764
    Arthrogryposis, distal, 2A (DA2A)4--see VAR_0303762 Y S mis40--------
    VAR_0303814
    Arthrogryposis, distal, 2B (DA2B)4--see VAR_0303812 K E mis40--------
    VAR_0303744
    Arthrogryposis, distal, 2A (DA2A)4--see VAR_0303742 E G mis40--------
    VAR_0303754
    Arthrogryposis, distal, 2B (DA2B)4--see VAR_0303752 D Y mis40--------
    VAR_0303804
    Arthrogryposis, distal, 2A (DA2A)4--see VAR_0303802 V D mis40--------
    VAR_0303774
    Arthrogryposis, distal, 2A (DA2A)4--see VAR_0303772 R C mis40--------
    VAR_0303784
    Arthrogryposis, distal, 2A (DA2A)4--see VAR_0303782 R H mis40--------

    HapMap Linkage Disequilibrium report for MYH3 (10531843 - 10560626 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MYH3: --
    Human Gene Mutation Database (HGMD): MYH3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYH3
    DNA2.0 Custom Variant and Variant Library Synthesis for MYH3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 160720   
    OMIM disorders: 193700  601680  
    UniProtKB/Swiss-Prot: MYH3_HUMAN, P11055
  • Arthrogryposis, distal, 2A (DA2A) [MIM:193700]: A form of distal arthrogryposis, a disease characterized
    by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a
    primary neurological or muscle disease. DA2A is characterized by contractures of the hands and feet,
    oropharyngeal abnormalities, scoliosis, and a distinctive face that includes a very small oral orifice, puckered
    lips, and an H-shaped dimple of the chin. Note=The disease is caused by mutations affecting the gene represented
    in this entry
  • Arthrogryposis, distal, 2B (DA2B) [MIM:601680]: A form of distal arthrogryposis, a disease characterized
    by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a
    primary neurological or muscle disease. DA2B is characterized by contractures of the hands and feet, and a
    distinctive face characterized by prominent nasolabial folds, small mouth and downslanting palpebral fissures.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 9 diseases for MYH3:    
    About MalaCards
    myh3-related arthrogryposis multiplex congenita, distal, type 2b    pleomorphic rhabdomyosarcoma    distal arthrogryposis type 5    freeman sheldon syndrome
    arthrogryposis distal type 2b    arthyrgryposis, distal, type 2b    arthrogryposis multiplex congenita distal type 1    congenital contractures
    distal muscular dystrophy

    4 diseases from the University of Copenhagen DISEASES database for MYH3:
    Distal arthrogryposis     Clubfoot     Distal muscular dystrophy     Ophthalmoplegia

    Find genes that share disorders with MYH3           About GenesLikeMe

    1 Novoseek inferred disease relationship for MYH3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prolapse 42.7 2 16579921 (1), 12861146 (1)

    Genetic Association Database (GAD): MYH3
    Human Genome Epidemiology (HuGE) Navigator: MYH3 (6 documents)

    Export disorders for MYH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MYH3 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with MYH3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nucleotide sequence of full length human embryonic myosin heavy chain cDNA. (PubMed id 2726495)1, 2, 3 Eller M.S.... Sarkar S. (Nucleic Acids Res. 1989)
    2. Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot. (PubMed id 20357587)1, 4 Shyy W....Morcuende J.A. (J Pediatr Orthop 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Skeletal muscle contractile gene (TNNT3, MYH3, TPM2) mutations not found in vertical talus or clubfoot. (PubMed id 19142688)1, 4 Gurnett C.A....Dobbs M.B. (Clin. Orthop. Relat. Res. 2009)
    5. Replication of a genome-wide case-control study of esophageal squamous cell carcinoma. (PubMed id 18649358)1, 4 Ng D....Taylor P.R. (Int. J. Cancer 2008)
    6. Mutations in embryonic myosin heavy chain (MYH3) cause Freeman- Sheldon syndrome and Sheldon-Hall syndrome. (PubMed id 16642020)1, 2 Toydemir R.M....Bamshad M.J. (Nat. Genet. 2006)
    7. Identification of three developmentally controlled isoforms of human myosin heavy chains. (PubMed id 1691980)1, 2 Bober E....Arnold H.H. (Eur. J. Biochem. 1990)
    8. Expression and DNA sequence analysis of a human embryonic skeletal muscle myosin heavy chain gene. (PubMed id 2771643)1, 2 Karsch-Mizrachi I.... Leinwand L.A. (Nucleic Acids Res. 1989)
    9. Human embryonic myosin heavy chain cDNA. Interspecies sequence conservation of the myosin rod, chromosomal locus and isoform specific transcription of the gene. (PubMed id 2806546)1, 2 Eller M.S.... Sarkar S. (FEBS Lett. 1989)
    10. Skeletal muscle heavy-chain polypeptide 3 and myosin binding protein H in the pubococcygeus muscle in patients with and without pelvic organ prolapse. (PubMed id 16579921)1, 9 Hundley A.F....Visco A.G. (Am. J. Obstet. Gynecol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4621 HGNC: 7573 AceView: MYH3 Ensembl:ENSG00000109063 euGenes: HUgn4621
    ECgene: MYH3 Kegg: 4621 H-InvDB: MYH3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MYH3 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=MYH3[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MYH3 gene:
    Search GeneIP for patents involving MYH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MYH3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for MYH3  
     OriGene MassSpec for MYH3   OriGene clones in human, mouse for MYH3  
     OriGene qSTAR qPCR primer pairs in human, mouse for MYH3   OriGene Purified Protein for MYH3  
     OriGene ORF clones in mouse, rat for MYH3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MYH3   OriGene Custom Protein Services for MYH3  

     
     
     Block miRNA regulation of human, mouse, rat MYH3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MYH3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYH3 Predesigned siRNA for gene silencing in human, mouse, rat MYH3
     QuantiFast Probe-based Assays in human, mouse, rat MYH3 QuantiTect SYBR Green Assays in human, mouse, rat MYH3
     Custom PCR Arrays for MYH3 Search Chromatin IP Primers for MYH3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYH3  Search GeneGlobe Interaction Network for MYH3
     Regulatory tfbs in MYH3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MYH3 GenScript cDNA clones with any tag delivered in your preferred vector for MYH3
     GenScript Custom Assay Services for MYH3 GenScript Custom overexpressing Cell Line Services for MYH3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for MYH3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MYH3 antibodies
     MYH3 proteins
     MYH3 lysates
     Antibodies for MYH3
     See all of Abcam's Antibodies, Kits and Proteins for MYH3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MYH3
     Antibodies for MYH3
     ELISAs for MYH3
     CLIAs for MYH3



     Browse ESI BIO Cell Lines and PureStem Progenitors for MYH3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MYH3
     SwitchGear Promoter luciferase reporter plasmids for MYH3
     Search ThermoFisher Antibodies for MYH3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYH3
     Browse compounds at ApexBio
     Search Addgene for plasmids for MYH3
      Search eBioscience for proteins for MYH3
      Search eBioscience for elisas for MYH3
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for MYH3
     antibodies-online antibodies for MYH3 (7 products)
     antibodies-online kits for MYH3 (9 products)
      Search antibodies-online for peptides for MYH3
     antibodies-online proteins for MYH3 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MYH3 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4