Aliases for MYH3 Gene
- Myosin, Heavy Chain 3, Skeletal Muscle, Embryonic 2 3
- Myosin, Heavy Polypeptide 3, Skeletal Muscle, Embryonic 2 3
- Myosin Heavy Chain, Fast Skeletal Muscle, Embryonic 3 4
- SMHCE 3 4
- Myosin, Skeletal, Heavy Chain, Embryonic 1 3
- Muscle Embryonic Myosin Heavy Chain 3 2
- Muscle Embryonic Myosin Heavy Chain 4
- Myosin Heavy Chain 3 4
External Ids for MYH3 Gene
Previous GeneCards Identifiers for MYH3 Gene
Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for MYH3 Gene
MYH3 (Myosin, Heavy Chain 3, Skeletal Muscle, Embryonic) is a Protein Coding gene. Diseases associated with MYH3 include myh3-related arthrogryposis multiplex congenita, distal, type 2b and distal arthrogryposis. Among its related pathways are RhoGDI Pathway and PAK Pathway. GO annotations related to this gene include calmodulin binding and motor activity. An important paralog of this gene is MYH4.
UniProtKB/Swiss-Prot for MYH3 Gene
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.