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MYH2 Gene

protein-coding GIFtS: 62

GC17M010365

myosin, heavy chain 2, skeletal muscle, adult
(Previous names: myosin, heavy polypeptide 2, skeletal muscle, adult )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MYH2A ^¹, ²
MYHSA2 ^¹, ², ³
MYHas8 ^¹, ²
MyHC-2A ^¹, ²
MyHC-2a ^³
MyHC-IIa ^¹, ², ³

Descriptions
Myosin heavy chain 2 ^³
Myosin heavy chain 2a ^³
Myosin heavy chain IIa ^³
Myosin heavy chain, skeletal muscle, adult 2 ^³
myosin, heavy chain 2, skeletal muscle, adult ^²
myosin, heavy polypeptide 2, skeletal muscle, adult ^¹, ²

External Ids
HGNC: 7572¹
Entrez Gene: 4620²
UniProtKB: Q9UKX2³
Ensembl: ENSG00000125414⁷

Search outside databases for aliases for MYH2 gene

Previous GC identifers: GC17M010762 GC17M011539 GC17M010367 GC17M010625

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MYH2_HUMAN, Q9UKX2

Function: Muscle contraction. Required for cytoskeleton organization (By similarity)

Gene Wiki entry for MYH2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MYH2 gene

Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1

MYH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M010365: (about GC identifiers)

Start:	10,365,190 bp from pter
End:	10,393,742 bp from pter
Size:	28,553 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MYH2_HUMAN, Q9UKX2 (See protein sequence)

Recommended Name: Myosin-2

Size: 1941 amino acids; 223044 Da

Subunit: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2

alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2)

Subcellular location: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils

Miscellaneous: Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy

meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped

subfragment (S2)

Secondary accessions: A0AVL4 Q14322 Q16229 Q86T56

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001093582.1 NP_060004.3

ENSEMBL proteins:

ENSP00000245503 ENSP00000369120

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Myosin, cardiac Myosin type II, Fast Myosin Skeletal Heavy chain)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005730	nucleolus	IDA	18029348
GO:0005737	cytoplasm	IEA	--
GO:0005863	striated muscle thick filament	IEA	--
GO:0005925	focal adhesion	IDA	18029348
GO:0016459	myosin complex	IEA	--

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Antibodies for MYH2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for MYH2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Myosin, cardiac Myosin type II, Fast Myosin Skeletal Heavy chain), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for MYH2

Assays for MYH2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9UKX2

ProtoNet protein and cluster: Q9UKX2

3 Blocks protein families:

IPB000048 IQ calmodulin-binding region

IPB002928 Myosin tail

IPB004009 Myosin N-terminal SH3-like domain

UniProtKB/Swiss-Prot: MYH2_HUMAN, Q9UKX2

Domain: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat

pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils

Similarity: Contains 1 IQ domain

Similarity: Contains 1 myosin head-like domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MYH2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_017534

Applied Biosystems Silencer® siRNAs for MYH2

Sigma-Aldrich siRNA for MYH2

Sigma-Aldrich shRNA Panels and shRNA for MYH2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001100112
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001100112
untagged cDNA clones in CMV expression vector (see all 2): NM_001100112

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_017534

UniProtKB/Swiss-Prot: MYH2_HUMAN, Q9UKX2

Function: Muscle contraction. Required for cytoskeleton organization (By similarity)

Genatlas biochemistry entry for MYH2:

myosin,motor contractile protein moving towards the "plus" end of actin track,heavy polypeptide

2,skeletal muscle,adult

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000146	microfilament motor activity	TAS	10388558
GO:0000166	nucleotide binding	IEA	--
GO:0003779	actin binding	NAS	--
GO:0005516	calmodulin binding	NAS	--
GO:0005524	ATP binding	NAS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for MYH2 (Your Favorite Gene powered by Ingenuity)

Tight Junction Signaling
Hepatic Fibrosis / Hepatic Stellate Cell Activation
Calcium Signaling
Cellular Effects of Sildenafil (Viagra)
Actin Cytoskeleton Signaling

GeneDecks MYH2 for the pathways selected above

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5/6 Interacting proteins for MYH2 (ENSP00000245503³ Q9UKX2¹) via UniProtKB, MINT, and/or STRING (see all 6 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBAC1	Q9BSL1¹	EBI-1049626, EBI-749370
S100A4	ENSP00000346294³	STRING (score=.952)
MYL1	ENSP00000307280³	STRING (score=.893)
AMPD1	ENSP00000358551³	STRING (score=.747)
--	ENSP00000354222³	STRING (score=.957)
--	ENSP00000264777³	STRING (score=.721)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006941	striated muscle contraction	IEA	--
GO:0030049	muscle filament sliding	NAS	3904738

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for MYH2 available from Tocris Bioscience

Compound	Action	CAS number
(�)-Blebbistatin	Selective inhibitor of myosin II	[674289-55-5]

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2 Novoseek chemical compound relationships for MYH2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
actomyosin	71.86	1	15681228 (1)
calcium	0.00	7	12235157 (5), 12756252 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MYH2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_017534

Sigma-Aldrich siRNA for MYH2

Sigma-Aldrich shRNA Panels and shRNA for MYH2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001100112 NM_017534

REFSEQ mRNAs for MYH2 gene (2 alternative transcripts):

NM_001100112.1 NM_017534.5

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001100112 NM_017534

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001100112
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001100112
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001100112

Additional cDNA sequence:

AF111784.1 AK299440.1 AK300702.1 AK308102.1 BC093082.1 BC126409.1 BX510904.2 S73840.1

Z32858.1

15 DOTS entries:

DT.450952 DT.91651088 DT.87010282 DT.95134925 DT.121011709 DT.95333920 DT.100797147 DT.92452462

DT.95319948 DT.95335450 DT.102833389 DT.121011605 DT.121011611 DT.121011677 DT.91645919

24/360 AceView cDNA sequences (see all 360 ):

AA214068 F26883 AJ573934 F35608 F24083 F29771 F24623 AA180982

F27373 F25925 F26983 F36130 BX500391 F25815 AF111784 F26552

F16647 F29611 F17405 AA194327 F16303 F28725 CF552204 AL596540

highest scoring ESTs for MYH2:

AA197132 BF825383 BF840515 F32091 AL596551 AL596835 BX510904 S73840 AA085912 AA197098

Unigene Cluster for MYH2:

Myosin, heavy chain 2, skeletal muscle, adult

Hs.699445 [show with all ESTs]

Unigene Representative Sequence: NM_017534

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MYH2 (see all 13 )

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20a	·	20b	^	21a	·
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	21b	^	22	^	23	^	24a	·	24b	^	25	^	26	^	27	^	28	^	29	^	30	^	31a	·	31b	·	31c	^	32	^	33	^	34	^	35	^	36
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for MYH2

2 Ensembl transcripts including schematic representations:

ENST00000245503 ENST00000379794

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MYH2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MYH2

¹ / ² / ³

3 probe-sets matching MYH2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39101_at²^{, 3}	U95-A	2	1.00	0.97	1.00	1.00	S73840	0.60	0.62	0.61	1
204631_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_017534	0.40	0.50	0.45	1
204631_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks MYH2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAATGACTGA

SOURCE GeneReport for Unigene cluster: Hs.699445
Expression variation in blood from EXPOLDB for MYH2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MYH2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MYH2¹	--	myosin, heavy chain 2, skeletal muscle, adult	91.63(n) 97.68(a)	608242 XM_536642.2 XP_536642.2
chimpanzee (Pan troglodytes)	MYH2¹	--	myosin, heavy chain 2, skeletal muscle, adult	98.95(n) 98.86(a)	455073 XM_511838.2 XP_511838.2
cow (Bos taurus)	MYH2¹	--	myosin, heavy chain 2, skeletal muscle, adult	91.8(n) 96.75(a)	788772 XM_001255271.1 XP_001255272.1
rat (Rattus norvegicus)	Myh2¹	--	myosin, heavy polypeptide 2, skeletal muscle, adult	90.04(n) 97.05(a)	691644 XM_001077547.1 XP_001077547.1
mouse (Mus musculus)	Myh2^{1, 5}	11 (35.00 cM)⁵	myosin, heavy polypeptide 2, skeletal muscle, adult^{1, 5}	89.95(n)¹ 96.7(a)¹	17882¹ NM_001039545.1¹ NP_001034634.1¹ AF081358⁵ AJ002521⁵ (see all 12)

About this table Species with no ortholog for MYH2

ENSEMBL Gene Tree for MYH2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for MYH2 gene

MYH1² MYH4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/177 NCBI SNPs in MYH2 are shown (see all 177 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 80)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4791998^1,2	A,C,F	10394015(+)	`GGCACG/AGCATT`	2	--	ng3¹		4		NA EA	362
	rs11658164^1,2	C,H	10373514(+)	`CAAGGA/CCCCTT`	2	S/A	mis¹ ese³		4		EU EA WA	418
	rs4791999^1,2	A	10394155(+)	`AAGCGA/GTGTGC`	2	--	ng3¹		0	--	--	--	--
--	rs1042075^1,2	H	10370713(-)	`CAACAC/GCGAGG`	2	T/S	mis¹ ese³		4		EU EA WA	400
--	rs1042236^1,2	A,C,F,H	10368649(-)	`CTGGCT/CATGGT`	2	A/A	syn¹		7		EA MN EU WA NA	2154
--	rs12600539^1,2	A,C,F,H	10391541(+)	`TAACGT/CTCTTT`	2	E/E	syn¹		4		EU EA NA	368
--	rs11078850^1,2	A,C,F	10389494(+)	`TACACA/TGGCAG`	2	P/P	syn¹ ese³		1		NA	66
--	rs1042076^1,2	F	10370685(-)	`AAATAC/TGAGAC`	2	Y/Y	syn¹		1		MN	184
--	rs1042074^1,2	F	10370796(-)	`CGCCAT/CGACTG`	2	H/H	syn¹		1		MN	184
--	rs1042297^1,2	F	10367885(-)	`ACAGAT/CATTTC`	2	D/D	syn¹		1		MN	184

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HapMap Linkage Disequilibrium images for MYH2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 160740 disorders: 605637

UniProtKB/Swiss-Prot: MYH2_HUMAN, Q9UKX2

Defects in MYH2 are the cause of inclusion body myopathy type 3 (IBM3) [MIM:605637].

Hereditary inclusion body myopathies constitute a group of neuromuscular disorders characterized

by slowly progressive distal and proximal weakness and a typical muscle pathology including rimmed

vacuoles and filamentous inclusions. IBM3 is a variant of hereditary inclusion body myopathies and

is characterized by autosomal dominant myopathy with joint contracture, ophthalmoplegia and rimmed

vacuoles. Morphological analysis of muscle biopsies from patients indicate that the type 2A fibers

frequently were abnormal, whereas other fiber types appeared normal

3 Novoseek disease relationships for MYH2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
inclusion body myopathy	72.80	3	11889243 (1)
myopathy	51.51	7	15741996 (2), 14991352 (1), 11889243 (1)
atrophy	26.69	1	16672834 (1)

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Human Gene Mutation Database: MYH2

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/56 PubMed articles for MYH2 gene (see all 56 ):

Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle. (PubMed id 7545970)^{2, 3, 4} Smerdu V....Schiaffino S. (1994)
Mutations and sequence variation in the human myosin heavy chain IIa gene (MYH2). (PubMed id 15741996)^{1, 3, 4} Tajsharghi H.... Oldfors A. (2005)
Autosomal dominant myopathy: missense mutation (Glu-706 --> Lys) in the myosin heavy chain IIa gene. (PubMed id 11114175)^{1, 3, 4} Martinsson T.... Wahlstroem J. (2000)
Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity. (PubMed id 10388558)^{1, 3, 4} Weiss A.... Leinwand L.A. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Characterization of human skeletal muscle fibres according to the myosin heavy chains they express. (PubMed id 7751403)^{3, 4} Ennion S.... Goldspink G. (1995)
Myosin heavy chain IIa gene mutation E706K is pathogenic and its expression increases with age. (PubMed id 11889243)^{1, 3} Tajsharghi H....Oldfors A. (2002)
Intracellular calcium and myosin isoform transitions. Calcineurin and calcium-calmodulin kinase pathways regulate preferential activation of the IIa myosin heavy chain promoter. (PubMed id 12235157)^{1, 3} Allen D.L. and Leinwand L.A. (2002)
Characterization of the metastasis-associated protein, S100A4. Roles of calcium binding and dimerization in cellular localization and interaction with myosin. (PubMed id 12756252)^{1, 3} Kim E.J. and Helfman D.M. (2003)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)³ Barbe L....Andersson-Svahn H. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4620	HGNC: 7572	AceView: MYH1andMYH4andMYH2	Ensembl:ENSG00000125414	euGenes: HUgn4620
ECgene: MYH2	H-InvDB: MYH2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for MYH2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for MYH2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MYH2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MYH2		Antibodies for MYH2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MYH2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Recombinant Proteins (Myosin, cardiac Myosin type II, Fast Myosin Skeletal Heavy chain)
	Antibodies (Myosin, cardiac Myosin type II, Fast Myosin Skeletal Heavy chain)

Search OriGene for MYH2

Tocris compounds for MYH2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for MYH2

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MYH2 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for MYH2

Summaries
for MYH2

Genomic Location
for MYH2

Proteins
for MYH2

Protein Domains/
Families
for MYH2

Gene Function
for MYH2

Pathways & Interactions
for MYH2

Drugs & Compounds
for MYH2

Transcripts
for MYH2

Expression
for MYH2

Orthologs
for MYH2

Paralogs
for MYH2

SNPs/Variants
for MYH2

Disorders & Mutations
for MYH2

Medical News
for MYH2

Publications
for MYH2

Search for MYH2

Genome Databases showing MYH2

Other Databases showing MYH2

Specialized Databases showing MYH2

Licensable Technologies
for MYH2

Services
for MYH2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MYH2 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor MYH2

Summariesfor MYH2

Genomic Locationfor MYH2

Proteinsfor MYH2

Protein Domains/Familiesfor MYH2

Gene Functionfor MYH2

Pathways & Interactionsfor MYH2

Drugs & Compoundsfor MYH2

Transcriptsfor MYH2

Expression for MYH2

Orthologsfor MYH2

Paralogsfor MYH2

SNPs/Variantsfor MYH2

Disorders & Mutationsfor MYH2

Medical Newsfor MYH2

Publicationsfor MYH2

Search for MYH2

Genome Databases showing MYH2

Other Databases showing MYH2

Specialized Databases showing MYH2

Licensable Technologiesfor MYH2

Servicesfor MYH2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MYH2

Summaries
for MYH2

Genomic Location
for MYH2

Proteins
for MYH2

Protein Domains/
Families
for MYH2

Gene Function
for MYH2

Pathways & Interactions
for MYH2

Drugs & Compounds
for MYH2

Transcripts
for MYH2

Expression
for MYH2

Orthologs
for MYH2

Paralogs
for MYH2

SNPs/Variants
for MYH2

Disorders & Mutations
for MYH2

Medical News
for MYH2

Publications
for MYH2

Licensable Technologies
for MYH2

Services
for MYH2