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Aliases for MYH16 Gene

Aliases for MYH16 Gene

  • Myosin, Heavy Chain 16 Pseudogene 2 3
  • Myosin, Heavy Polypeptide 16 2 3
  • Myosin, Heavy Polypeptide 5 2 3
  • Sarcomeric Myosin 2 3
  • MYH5 3 4
  • Myosin Heavy Chain 16 Pseudogene 4
  • Myosin Heavy Polypeptide 5 4
  • Myosin, Heavy Chain 16 2
  • MYH16P 3
  • MHC20 3

External Ids for MYH16 Gene

Previous HGNC Symbols for MYH16 Gene

  • MYH5

Previous GeneCards Identifiers for MYH16 Gene

  • GC07U901194
  • GC07P098448
  • GC07P098516
  • GC07P098708
  • GC07P098870
  • GC07P093506

Summaries for MYH16 Gene

Entrez Gene Summary for MYH16 Gene

  • The MYH16 gene, encoding a sarcomeric myosin heavy chain expressed in nonhuman primate masticatory muscles, is inactivated in humans. Stedman et al. (2004) [PubMed 15042088] hypothesized that the decrement in masticatory muscle size caused by the inactivation of MYH16 removed an evolutionary constraint on encephalization in early man.[supplied by OMIM, Mar 2008]

GeneCards Summary for MYH16 Gene

MYH16 (Myosin, Heavy Chain 16 Pseudogene) is a Pseudogene. Among its related pathways are Immune response CCR3 signaling in eosinophils and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases.

UniProtKB/Swiss-Prot for MYH16 Gene

  • Has most probably lost the function in masticatory muscles contraction suspected for its homologs in dog (AC F1PT61) and apes.

Tocris Summary for MYH16 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYH16 Gene

Genomics for MYH16 Gene

Regulatory Elements for MYH16 Gene

Genomic Location for MYH16 Gene

99,238,794 bp from pter
99,311,130 bp from pter
72,337 bases
Plus strand

Genomic View for MYH16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MYH16 Gene

Proteins for MYH16 Gene

  • Protein details for MYH16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative uncharacterized protein MYH16
    Protein Accession:

    Protein attributes for MYH16 Gene

    1097 amino acids
    Molecular mass:
    128290 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15219.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for MYH16 Gene

Proteomics data for MYH16 Gene at MOPED

Post-translational modifications for MYH16 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MYH16 Gene

Domains & Families for MYH16 Gene

Gene Families for MYH16 Gene

Protein Domains for MYH16 Gene


Suggested Antigen Peptide Sequences for MYH16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYH16: view

Function for MYH16 Gene

Molecular function for MYH16 Gene

UniProtKB/Swiss-Prot Function:
Has most probably lost the function in masticatory muscles contraction suspected for its homologs in dog (AC F1PT61) and apes.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYH16 Gene

Localization for MYH16 Gene

Subcellular locations from

Jensen Localization Image for MYH16 Gene COMPARTMENTS Subcellular localization image for MYH16 gene
Compartment Confidence
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MYH16 Gene

Drugs & Compounds for MYH16 Gene

(4) Additional Compounds for MYH16 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MYH16: view

Transcripts for MYH16 Gene

mRNA/cDNA for MYH16 Gene

(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MYH16 Gene

No ASD Table

Relevant External Links for MYH16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYH16 Gene

mRNA expression in normal human tissues for MYH16 Gene

mRNA differential expression in normal tissues according to GTEx for MYH16 Gene

This gene is overexpressed in Testis (x24.2).

SOURCE GeneReport for Unigene cluster for MYH16 Gene Hs.621401

mRNA Expression by UniProt/SwissProt for MYH16 Gene

Tissue specificity: Specifically expressed in muscles of the head including temporalis and tensor veli palatini.
genes like me logo Genes that share expression patterns with MYH16: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MYH16 Gene

Orthologs for MYH16 Gene

Evolution for MYH16 Gene

Gene Tree for MYH16 (if available)
Gene Tree for MYH16 (if available)

No data available for Orthologs for MYH16 Gene

Paralogs for MYH16 Gene

(14) SIMAP similar genes for MYH16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MYH16: view

No data available for Paralogs for MYH16 Gene

Variants for MYH16 Gene

Sequence variations from dbSNP and Humsavar for MYH16 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs732332 -- 99,276,598(-) GAGCA(C/T)TTGCT intron-variant
rs886619 -- 99,276,855(-) tctct(C/G)atttt intron-variant
rs886620 -- 99,276,745(-) AAGTC(A/G)CACCT intron-variant
rs2008424 -- 99,275,991(-) CAGCA(C/G)TTTGG intron-variant
rs6150247 -- 99,277,057(+) AGAGA(-/CACAGAGAGAGAGAGA)GAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYH16 Gene

Variant ID Type Subtype PubMed ID
nsv831068 CNV Loss 17160897
esv2661738 CNV Deletion 23128226

Relevant External Links for MYH16 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MYH16 Gene

Disorders for MYH16 Gene

Relevant External Links for MYH16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MYH16: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYH16 Gene

Publications for MYH16 Gene

  1. Muscle-specific integrins in masseter muscle fibers of chimpanzees: an immunohistochemical study. (PMID: 20430719) Favaloro A. … Anastasi G. (Folia Histochem. Cytobiol. 2009) 23 67
  2. Ghosts of the past I: some muscles and fasciae in the head domain. (PMID: 18703876) Oxnard C.E. … Franklin D. (Folia Primatol. 2008) 23 67
  3. Comparative analyses reveal a complex history of molecular evolution for human MYH16. (PMID: 15470226) Perry G.H. … Stone A.C. (Mol. Biol. Evol. 2005) 23 67
  4. Evolution of sarcomeric myosin heavy chain genes: evidence from fish. (PMID: 15014174) McGuigan K. … Postlethwait J.H. (Mol. Biol. Evol. 2004) 2 67
  5. Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family. (PMID: 11919279) Desjardins P.R. … Stedman H.H. (Mol. Biol. Evol. 2002) 2 67

Products for MYH16 Gene

Sources for MYH16 Gene

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