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Aliases for MYH16 Gene

Aliases for MYH16 Gene

  • Myosin, Heavy Chain 16 Pseudogene 2 3 5
  • Myosin Heavy Chain 16 Pseudogene 3 4
  • Myosin, Heavy Polypeptide 16 2 3
  • Myosin, Heavy Polypeptide 5 2 3
  • Myosin Heavy Polypeptide 5 3 4
  • Sarcomeric Myosin 2 3
  • MYH5 3 4
  • Putative Uncharacterized Protein MYH16 3
  • Myosin, Heavy Chain 16 2
  • MYH16P 3
  • MHC20 3

External Ids for MYH16 Gene

Previous HGNC Symbols for MYH16 Gene

  • MYH5

Previous GeneCards Identifiers for MYH16 Gene

  • GC07U901194
  • GC07P098448
  • GC07P098516
  • GC07P098708
  • GC07P098870
  • GC07P093506

Summaries for MYH16 Gene

Entrez Gene Summary for MYH16 Gene

  • The MYH16 gene, encoding a sarcomeric myosin heavy chain expressed in nonhuman primate masticatory muscles, is inactivated in humans. Stedman et al. (2004) [PubMed 15042088] hypothesized that the decrement in masticatory muscle size caused by the inactivation of MYH16 removed an evolutionary constraint on encephalization in early man.[supplied by OMIM, Mar 2008]

GeneCards Summary for MYH16 Gene

MYH16 (Myosin, Heavy Chain 16 Pseudogene) is a Pseudogene. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Immune response CCR3 signaling in eosinophils.

UniProtKB/Swiss-Prot for MYH16 Gene

  • Has most probably lost the function in masticatory muscles contraction suspected for its homologs in dog (AC F1PT61) and apes.

Tocris Summary for MYH16 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYH16 Gene

Genomics for MYH16 Gene

Regulatory Elements for MYH16 Gene

Genomic Location for MYH16 Gene

Chromosome:
7
Start:
99,238,794 bp from pter
End:
99,311,130 bp from pter
Size:
72,337 bases
Orientation:
Plus strand

Genomic View for MYH16 Gene

Genes around MYH16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYH16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYH16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYH16 Gene

Proteins for MYH16 Gene

  • Protein details for MYH16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6N6-MYH16_HUMAN
    Recommended name:
    Putative uncharacterized protein MYH16
    Protein Accession:
    Q9H6N6

    Protein attributes for MYH16 Gene

    Size:
    1097 amino acids
    Molecular mass:
    128290 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15219.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for MYH16 Gene

Proteomics data for MYH16 Gene at MOPED

Post-translational modifications for MYH16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYH16 Gene

Domains & Families for MYH16 Gene

Gene Families for MYH16 Gene

Protein Domains for MYH16 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYH16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6N6

UniProtKB/Swiss-Prot:

MYH16_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYH16: view

Function for MYH16 Gene

Molecular function for MYH16 Gene

UniProtKB/Swiss-Prot Function:
Has most probably lost the function in masticatory muscles contraction suspected for its homologs in dog (AC F1PT61) and apes.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYH16 Gene

Localization for MYH16 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYH16 Gene COMPARTMENTS Subcellular localization image for MYH16 gene
Compartment Confidence
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MYH16 Gene

Drugs & Compounds for MYH16 Gene

(5) Additional Compounds for MYH16 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-Blebbistatin
674289-55-5
(R)-(+)-Blebbistatin
1177356-70-5
(S)-(-)-Blebbistatin
856925-71-8
ML 9 hydrochloride
105637-50-1
W-7 hydrochloride
61714-27-0

(5) Tocris Compounds for MYH16 Gene

Compound Action Cas Number
(+-)-Blebbistatin Selective inhibitor of myosin II ATPase activity 674289-55-5
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 1177356-70-5
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760) 856925-71-8
ML 9 hydrochloride Myosin light chain kinase inhibitor 105637-50-1
W-7 hydrochloride Calmodulin antagonist. Inhibits myosin light chain kinase 61714-27-0
genes like me logo Genes that share compounds with MYH16: view

Transcripts for MYH16 Gene

mRNA/cDNA for MYH16 Gene

(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MYH16 Gene

No ASD Table

Relevant External Links for MYH16 Gene

GeneLoc Exon Structure for
MYH16
ECgene alternative splicing isoforms for
MYH16

Expression for MYH16 Gene

mRNA expression in normal human tissues for MYH16 Gene

mRNA differential expression in normal tissues according to GTEx for MYH16 Gene

This gene is overexpressed in Testis (x24.2).

SOURCE GeneReport for Unigene cluster for MYH16 Gene Hs.621401

mRNA Expression by UniProt/SwissProt for MYH16 Gene

Q9H6N6-MYH16_HUMAN
Tissue specificity: Specifically expressed in muscles of the head including temporalis and tensor veli palatini.
genes like me logo Genes that share expression patterns with MYH16: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MYH16 Gene

Orthologs for MYH16 Gene

Evolution for MYH16 Gene

ENSEMBL:
Gene Tree for MYH16 (if available)
TreeFam:
Gene Tree for MYH16 (if available)

No data available for Orthologs for MYH16 Gene

Paralogs for MYH16 Gene

(14) SIMAP similar genes for MYH16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MYH16: view

No data available for Paralogs for MYH16 Gene

Variants for MYH16 Gene

Sequence variations from dbSNP and Humsavar for MYH16 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs886619 -- 99,276,855(-) tctct(C/G)atttt intron-variant
rs886620 -- 99,276,745(-) AAGTC(A/G)CACCT intron-variant
rs732332 -- 99,276,598(-) GAGCA(C/T)TTGCT intron-variant
rs2008424 -- 99,275,991(-) CAGCA(C/G)TTTGG intron-variant
rs6150247 -- 99,277,057(+) AGAGA(-/CACAGAGAGAGAGAGA)GAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYH16 Gene

Variant ID Type Subtype PubMed ID
nsv831068 CNV Loss 17160897
esv2661738 CNV Deletion 23128226

Relevant External Links for MYH16 Gene

HapMap Linkage Disequilibrium report
MYH16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MYH16 Gene

Disorders for MYH16 Gene

Relevant External Links for MYH16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYH16

No disorders were found for MYH16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYH16 Gene

Publications for MYH16 Gene

  1. Myosin gene mutation correlates with anatomical changes in the human lineage. (PMID: 15042088) Stedman H.H. … Mitchell M.A. (Nature 2004) 3 4 67
  2. Comparative analyses reveal a complex history of molecular evolution for human MYH16. (PMID: 15470226) Perry G.H. … Stone A.C. (Mol. Biol. Evol. 2005) 3 23
  3. Evolution of sarcomeric myosin heavy chain genes: evidence from fish. (PMID: 15014174) McGuigan K. … Postlethwait J.H. (Mol. Biol. Evol. 2004) 2 3
  4. Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family. (PMID: 11919279) Desjardins P.R. … Stedman H.H. (Mol. Biol. Evol. 2002) 2 3
  5. Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks. (PMID: 24550385) Abu-Odeh M. … Aqeilan R.I. (J. Biol. Chem. 2014) 3

Products for MYH16 Gene

Sources for MYH16 Gene

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