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myosin, heavy chain 16 pseudogene(Previous names: myosin, heavy polypeptide 5, myosin, heavy polypeptide...)
(Previous symbol: MYH5)
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Aliases
for MYH16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Myosin, Heavy Chain 16 Pseudogene1 2 | | Myosin, Heavy Chain 161 | | MHC201 2 | | Myosin, Heavy Polypeptide 161 | | MYH16P1 2 | | Myosin, Heavy Polypeptide 51 | | MYH51 2 | | |
Export aliases for MYH16 gene to outside databasesPrevious GC identifers: GC07U901194 GC07P098448 GC07P098516 GC07P098708 GC07P093506 |
Summaries
for MYH16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MYH16:
The MYH16 gene, encoding a sarcomeric myosin heavy chain expressed in nonhuman primate masticatory muscles, isinactivated in humans. Stedman et al. (2004) (PubMed 15042088) hypothesized that the decrement in masticatory musclesize caused by the inactivation of MYH16 removed an evolutionary constraint on encephalization in early man.(suppliedby OMIM, Mar 2008)
 summary
for MYH16: Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.
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Genomic Views
for MYH16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MYH16 gene promoter:
MEF-2A MyoD aMEF-2 Nkx2-5
Other transcription factors
Search SABiosciences Chromatin IP Primers for MYH16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYH16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22.1MYH16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P098870: view genomic region
(about GC identifiers)
Start:
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98,836,417 bp from pter |
End:
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98,908,753 bp from pter |
Size:
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72,337 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 98,230,872-98,255,542 |
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Proteins
for MYH16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/TrEMBL: Q9H6N6 (See
protein sequence)Recommended Name: cDNA: FLJ22037 fis, clone HEP08868 Size: 746 amino acids; 86993 Da |
Protein
Domains /
Families
for MYH16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MYH16 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H6N6ProtoNet protein and cluster: Q9H6N6 |
Function
for MYH16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH16 |
|
Pathways & Interactions
for MYH16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell adhesion_Integrin-mediated cell adhesion and migration | | | 2 | Immune response _CCR3 signaling in eosinophils | | | 3 | Cell adhesion Tight junctions | | | 4 | Development MAG-dependent inhibition of neurite outgrowth | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5  EMD Millipore Pathways for MYH16
5/6  GeneGo (Thomson Reuters) Pathways for MYH16 (see all 6)
MYH16 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYH16
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Drugs & Compounds
for MYH16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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Compounds for MYH16 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| (R)-(+)-Blebbistatin | Selective inhibitor of myosin II. Inactive enantiomer of (±)-blebbistatin (Cat. No. 1760) | -- | | (S)-(-)-Blebbistatin | Selective inhibitor of myosin II. Active enantiomer of (±)-blebbistatin (Cat. No. 1760) | [856925-71-8] | | (±)-Blebbistatin | Selective inhibitor of myosin II | [674289-55-5] |
Search CenterWatch for drugs/clinical trials and news about MYH16
|
Transcripts
for MYH16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
Unigene Cluster for MYH16: Myosin, heavy chain 16 pseudogene Hs.621401 Unigene Representative Sequence: AK0256908 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000439784 ENST00000453194 ENST00000413734 ENST00000425880 ENST00000452010
ENST00000429079 ENST00000453378 ENST00000330888(uc003upw.3)
Additional cDNA sequence: AK025690.1 NR_002147.2 1 DOTS entry: DT.97775306
GeneLoc Exon Structure
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Expression
for MYH16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MYH16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for MYH16
SOURCE GeneReport for Unigene cluster: Hs.621401
SABiosciences Custom PCR Arrays for MYH16
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYH16
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MYH16 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYH16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYH16 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH16 |
Orthologs
for MYH16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for MYH16 (if available)
TreeFam Gene Tree for MYH16 (if available) |
Paralogs
for MYH16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MYH16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MYH16 (98836417 - 98908753 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MYH16
1 CNV: 4547 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MYH16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MYH16 for disorders About GeneDecksing
OMIM gene information: 608580
OMIM disorders: --
1  disease for MYH16: About MalaCardsencephalitis
Export disorders for MYH16 gene to outside databases
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Publications
for MYH16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MYH16 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MYH16) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Evolution of sarcomeric myosin heavy chain genes: evi dence from fish. (PubMed id 15014174)1, 3 McGuigan K....Postlethwait J.H. (2004)
- Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family. (PubMed id 11919279)1, 3 Desjardins P.R....Stedman H.H. (2002)
- Comparative analyses reveal a complex history of molecular evolution for human MYH16. (PubMed id 15470226)1, 9 Perry G.H....Stone A.C. (2005)
- Comparative genomics search for losses of long-established genes on the human lineage. (PubMed id 18085818)1 Zhu J....Haussler D. (2007)
- Myosin gene mutation correlates with anatomical changes in the human lineage. (PubMed id 15042088)1 Stedman H.H....Mitchell M.A. (2004)
- Muscle-specific integrins in masseter muscle fibers o f chimpanzees: an immunohistochemical study. (PubMed id 20430719)9 Favaloro A....Anastasi G. (2009)
- Ghosts of the past I: some muscles and fasciae in the head domain. (PubMed id 18703876)9 Oxnard C.E. and Franklin D. (2008)
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External Searches for MYH16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MYH16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MYH16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MYH16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MYH16 gene:
Search GeneIP for patents involving MYH16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MYH16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MYH16 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYH16 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYH16 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYH16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYH16 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYH16 |
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| | | | Tocris compounds for MYH16 |
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 | | | MYH16 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH16 |
|  |  |  | | | | Search ThermoFisher Antibodies for MYH16 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MYH16 |
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