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Aliases for MYH15 Gene

Aliases for MYH15 Gene

  • Myosin, Heavy Chain 15 2 3
  • Myosin, Heavy Polypeptide 15 2 3
  • Myosin Heavy Chain 15 4
  • Myosin-15 3
  • KIAA1000 4

External Ids for MYH15 Gene

Previous GeneCards Identifiers for MYH15 Gene

  • GC03M109581
  • GC03M108108
  • GC03M105472

Summaries for MYH15 Gene

GeneCards Summary for MYH15 Gene

MYH15 (Myosin, Heavy Chain 15) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and ERK Signaling. GO annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYH4.

UniProtKB/Swiss-Prot for MYH15 Gene

  • Muscle contraction.

Tocris Summary for MYH15 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name), almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II. Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by intracellular Ca2+ concentrations.

Gene Wiki entry for MYH15 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYH15 Gene

Genomics for MYH15 Gene

Regulatory Elements for MYH15 Gene

Genomic Location for MYH15 Gene

Start:
108,380,369 bp from pter
End:
108,529,322 bp from pter
Size:
148,954 bases
Orientation:
Minus strand

Genomic View for MYH15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYH15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYH15 Gene

Proteins for MYH15 Gene

  • Protein details for MYH15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2K3-MYH15_HUMAN
    Recommended name:
    Myosin-15
    Protein Accession:
    Q9Y2K3
    Secondary Accessions:

    Protein attributes for MYH15 Gene

    Size:
    1946 amino acids
    Molecular mass:
    224619 Da
    Quaternary structure:
    • Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
    SequenceCaution:
    • Sequence=BAA76844.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for MYH15 Gene

Proteomics data for MYH15 Gene at MOPED

Post-translational modifications for MYH15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYH15 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MYH15 Gene

Domains for MYH15 Gene

Gene Families for MYH15 Gene

HGNC:
  • MYHII :Myosins / Myosin superfamily : Class II

Suggested Antigen Peptide Sequences for MYH15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2K3

UniProtKB/Swiss-Prot:

MYH15_HUMAN :
  • Q9Y2K3
Domain:
  • The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
  • Contains 1 IQ domain.
  • Contains 1 myosin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYH15: view

Function for MYH15 Gene

Molecular function for MYH15 Gene

UniProtKB/Swiss-Prot Function: Muscle contraction.

Gene Ontology (GO) - Molecular Function for MYH15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYH15: view

Phenotypes for MYH15 Gene

GenomeRNAi human phenotypes for MYH15:
genes like me logo Genes that share phenotypes with MYH15: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MYH15 Gene

Localization for MYH15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYH15 Gene

Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYH15 Gene COMPARTMENTS Subcellular localization image for MYH15 gene
Compartment Confidence
cytoskeleton 3
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MYH15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0016459 myosin complex --
GO:0030016 myofibril IEA --
GO:0032982 myosin filament IEA --
genes like me logo Genes that share ontologies with MYH15: view

Pathways for MYH15 Gene

genes like me logo Genes that share pathways with MYH15: view

Interacting Proteins for MYH15 Gene

Gene Ontology (GO) - Biological Process for MYH15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with MYH15: view

Compounds for MYH15 Gene

(4) Tocris Compounds for MYH15 Gene

Compound Action Cas Number
(�)-Blebbistatin Selective inhibitor of myosin II ATPase activity [674289-55-5]
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (�)-blebbistatin (Cat. No. 1760) [1177356-70-5]
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (�)-blebbistatin (Cat. No. 1760) [856925-71-8]
BTS Selective inhibitor of skeletal muscle myosin II ATPase activity [1576-37-0]
genes like me logo Genes that share compounds with MYH15: view

Transcripts for MYH15 Gene

mRNA/cDNA for MYH15 Gene

(19) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYH15 Gene

Myosin, heavy chain 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYH15 Gene

No ASD Table

Relevant External Links for MYH15 Gene

GeneLoc Exon Structure for
MYH15
ECgene alternative splicing isoforms for
MYH15

Expression for MYH15 Gene

mRNA expression in normal human tissues for MYH15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYH15 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MYH15 Gene

SOURCE GeneReport for Unigene cluster for MYH15 Gene Hs.731060

genes like me logo Genes that share expressions with MYH15: view

No data available for mRNA Expression by UniProt/SwissProt for MYH15 Gene

Orthologs for MYH15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYH15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYH15 35
  • 99.43 (n)
  • 99.02 (a)
MYH15 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYH15 35
  • 86.04 (n)
  • 80.42 (a)
MYH15 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYH15 35
  • 87.45 (n)
  • 83.44 (a)
MYH15 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myh15 35
  • 82.1 (n)
  • 75.69 (a)
Myh15 16
Myh15 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYH15 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myh15 35
  • 81.03 (n)
  • 74.72 (a)
chicken
(Gallus gallus)
Aves MYH15 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYH15 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mhc 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea myo-1 36
  • 41 (a)
ManyToMany
myo-2 36
  • 41 (a)
ManyToMany
myo-3 36
  • 42 (a)
ManyToMany
myo-5 36
  • 43 (a)
ManyToMany
myo-6 36
  • 41 (a)
ManyToMany
unc-54 36
  • 43 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO1 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
Species with no ortholog for MYH15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MYH15 Gene

ENSEMBL:
Gene Tree for MYH15 (if available)
TreeFam:
Gene Tree for MYH15 (if available)

Paralogs for MYH15 Gene

Paralogs for MYH15 Gene

Selected SIMAP similar genes for MYH15 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MYH15: view

Variants for MYH15 Gene

Sequence variations from dbSNP and Humsavar for MYH15 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs897060 -- 108,513,758(-) AGTTA(C/T)GGAAA intron-variant
rs936257 -- 108,386,061(+) GTTTT(C/T)ATCTG intron-variant
rs936258 -- 108,386,240(+) AAGTG(C/G)TTGCT intron-variant
rs936266 -- 108,406,767(-) TAGAT(A/G)GCAAC intron-variant
rs936267 -- 108,433,871(-) GGGTA(C/T)GACat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYH15 Gene

Variant ID Type Subtype PubMed ID
nsv829656 CNV Loss 17160897
nsv829657 CNV Gain 17160897
nsv526190 CNV Gain 19592680
nsv3937 CNV Loss 18451855
esv268776 CNV Insertion 20981092
nsv829658 CNV Gain 17160897
dgv5229n71 CNV Loss 21882294

Relevant External Links for MYH15 Gene

HapMap Linkage Disequilibrium report
MYH15
Human Gene Mutation Database (HGMD)
MYH15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYH15 Gene

Disorders for MYH15 Gene

Relevant External Links for MYH15

Genetic Association Database (GAD)
MYH15
Human Genome Epidemiology (HuGE) Navigator
MYH15
genes like me logo Genes that share disorders with MYH15: view

No data available for UniProtKB/Swiss-Prot for MYH15 Gene

Publications for MYH15 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  2. Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family. (PMID: 11919279) Desjardins P.R. … Stedman H.H. (Mol. Biol. Evol. 2002) 3 4
  3. Evolution of sarcomeric myosin heavy chain genes: evidence from fish. (PMID: 15014174) McGuigan K. … Postlethwait J.H. (Mol. Biol. Evol. 2004) 2 3
  4. Myosin gene mutation correlates with anatomical changes in the human lineage. (PMID: 15042088) Stedman H.H. … Mitchell M.A. (Nature 2004) 2 3
  5. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 48

Products for MYH15 Gene

Sources for MYH15 Gene

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