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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYH15 Gene

protein-coding   GIFtS: 58
GCID: GC03M108108

Myosin, Heavy Chain 15

(Previous names: myosin, heavy polypeptide 15)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Myosin, Heavy Chain 151 2
Myosin, Heavy Polypeptide 151 2
myosin-152
KIAA10003
Myosin Heavy Chain 153

External Ids:    HGNC: 310731   Entrez Gene: 229892   Ensembl: ENSG000001448217   OMIM: 6099295   UniProtKB: Q9Y2K33   

Export aliases for MYH15 gene to outside databases

Previous GC identifers: GC03M109581 GC03M105472


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MYH15 Gene: 
MYH15 (myosin, heavy chain 15) is a protein-coding gene. Diseases associated with MYH15 include myocarditis, and coronary heart disease, and among its related super-pathways are Immune response CCR3 signaling in eosinophils and Cell adhesion Integrin-mediated cell adhesion and migration. GO annotations related to this gene include motor activity and actin binding. An important paralog of this gene is MYH8.

UniProtKB/Swiss-Prot: MYH15_HUMAN, Q9Y2K3
Function: Muscle contraction (By similarity)

summary for MYH15 Gene:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYH15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYH15 gene promoter:
         TBP   NF-1/L   ISGF-3   NF-1   HNF-1A   MEF-2A   S8   POU2F1   HNF-1   POU2F1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MYH15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYH15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.13   Ensembl cytogenetic band:  3q13.13   HGNC cytogenetic band: 3q13

MYH15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYH15 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M108108:  view genomic region     (about GC identifiers)

Start:
108,099,216 bp from pter      End:
108,248,169 bp from pter
Size:
148,954 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MYH15_HUMAN, Q9Y2K3 (See protein sequence)
Recommended Name: Myosin-15  
Size: 1946 amino acids; 224619 Da
Subunit: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain
subunits (MLC) and 2 regulatory light chain subunits (MLC-2) (By similarity)
Subcellular location: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils
Caution: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-15
(MYO15)
Sequence caution: Sequence=BAA76844.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Explore the universe of human proteins at neXtProt for MYH15: NX_Q9Y2K3

Explore proteomics data for MYH15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2K3

  • MYH15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MYH15 Protein Expression
    REFSEQ proteins: NP_055796.1  
    ENSEMBL proteins: 
     ENSP00000273353  

    Human Recombinant Protein Products for MYH15: 
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    Cloud-Clone Corp. Proteins for MYH15 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016459myosin complex ----
    GO:0030016myofibril IEA--
    GO:0032982myosin filament IEA--

    MYH15 for ontologies           About GeneDecksing



    MYH15 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for MYH15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MYHII: Myosins / Myosin superfamily : Class II

    5/6 InterPro protein domains (see all 6):
     IPR027401 Myosin-like_IQ_dom
     IPR015650 Myosin_1/23/4/7/8/13/15
     IPR004009 Myosin_N
     IPR027417 P-loop_NTPase
     IPR002928 Myosin_tail

    Graphical View of Domain Structure for InterPro Entry Q9Y2K3

    ProtoNet protein and cluster: Q9Y2K3

    3 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB002928 Myosin tail
    IPB004009 Myosin N-terminal SH3-like domain


    UniProtKB/Swiss-Prot: MYH15_HUMAN, Q9Y2K3
    Domain: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of
    4 heptapeptides, characteristic for alpha-helical coiled coils (By similarity)
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 myosin head-like domain


    MYH15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYH15_HUMAN, Q9Y2K3
    Function: Muscle contraction (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003774motor activity IEA--
    GO:0003779actin binding IEA--
    GO:0005516calmodulin binding IEA--
    GO:0005524ATP binding IEA--
         
    MYH15 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MYH15:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MYH15 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MYH15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYH15 
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate MYH15:
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH15


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MYH15 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune response CCR3 signaling in eosinophils
    Immune response CCR3 signaling in eosinophils0.51
    Inhibitory action of Lipoxins on neutrophil migration0.51
    2Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin-mediated cell adhesion and migration0.49
    Cell adhesion Tight junctions0.33
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    3Development MAG-dependent inhibition of neurite outgrowth
    Development MAG-dependent inhibition of neurite outgrowth0.87
    4Allograft rejection
    Viral myocarditis0.35
    5Tight junction
    Tight junction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for MYH15
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils
    Development MAG-dependent inhibition of neurite outgrowth


    5/6 GeneGo (Thomson Reuters) Pathways for MYH15 (see all 6)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Tight junctions


    2         Kegg Pathways  (Kegg details for MYH15):
        Tight junction
    Viral myocarditis


    MYH15 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYH15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/27 Interacting proteins for MYH15 (Q9Y2K33 ENSP000002733534) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DAXXQ9UER73I2D: score=2 
    ENSG00000206206Q9UER73I2D: score=2 
    ENSG00000206279Q9UER73I2D: score=2 
    ENSG00000227046Q9UER73I2D: score=2 
    ENSG00000231617Q9UER73I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MYH15 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BTSSelective inhibitor of skeletal muscle myosin II ATPase activity[1576-37-0]
    (R)-(+)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)[1177356-70-5]
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)[856925-71-8]
    (+-)-BlebbistatinSelective inhibitor of myosin II ATPase activity[674289-55-5]

    Search CenterWatch for drugs/clinical trials and news about MYH15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MYH15 gene: 
    NM_014981.1  

    Unigene Cluster for MYH15:

    Myosin, heavy chain 15
    Hs.731060  [show with all ESTs]
    Unigene Representative Sequence: AB023217
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273353(uc003dxa.1) ENST00000478998 ENST00000495753
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate MYH15:
    hsa-miR-3607-5p hsa-miR-576-5p hsa-miR-3613-3p hsa-miR-944 hsa-miR-664
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: MYH15 (NM_014981)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYH15
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYH15
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYH15

    Additional mRNA sequence: 

    AB023217.3 AK055436.1 AK126801.1 

    4 DOTS entries:

    DT.91734160  DT.75122754  DT.91734159  DT.97787955 

    19 AceView cDNA sequences:

    BU167145 AB023217 BX282440 AK055436 AL039898 AL705986 AK097806 BM474348 
    BF062942 AW450042 AK126801 CB135993 BQ368360 AV721706 BE798025 AW148535 
    CF139878 AI720204 T10409 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYH15 expression in normal human tissues (normalized intensities)      MYH15 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGATTAAA
    MYH15 Expression
    About this image


    MYH15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Skeletal Muscle (Muscoskeletal System)
             Multinuclear Myocyte Extraocular Muscles

    See MYH15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYH15

    SOURCE GeneReport for Unigene cluster: Hs.731060
        SABiosciences Custom PCR Arrays for MYH15
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYH15 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myh151 , 5 myosin, heavy chain 151, 5 82.1(n)1
    75.69(a)1
      16 (30.75 cM)5
    6677721  NM_001166210.11  NP_001159682.11 
     490574865 
    chicken
    (Gallus gallus)
    Aves MYH156
    myosin heavy chain, cardiac muscle isoform
    71(a)
    1 ↔ 1
    1(86879998-86923778)
    lizard
    (Anolis carolinensis)
    Reptilia MYH156
    Uncharacterized protein
    64(a)
    1 ↔ 1
    3(169209421-169365919)
    fruit fly
    (Drosophila melanogaster)
    Insecta Mhc6
    Myosin heavy chain
    47(a)
    1 → many
    2L(16766737-16788766)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-546
    myo-56
    (see all 6)
    Protein MYO-5
    (see all 6)
    43(a)
    42(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    I(14855899-14863540)
    V(8109051-8118130)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MYO16
    Type II myosin heavy chain, required for wild-type...
    26(a)
    1 → many
    VIII(151666-157452)


    ENSEMBL Gene Tree for MYH15 (if available)
    TreeFam Gene Tree for MYH15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYH15 gene
    MYH82  MYH12  MYH22  MYH112  MYH142  MYH92  MYH102  MYH132  
    MYH7B2  MYH42  MYH32  MYH62  MYH72  
    18/20 SIMAP similar genes for MYH15 using alignment to 3 protein entries:     MYH15_HUMAN (see all proteins) (see all similar genes):
    MYH7    MYH6    MYH4    MYH1    MYH13    MYH2
    MYH3    MYH8    MYH7B    MYH16    MYH9    MYH11
    MYH14    MYH10    MYO5B    MYO1D    MYO1A    DKFZp686A01173

    MYH15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3128 SNPs in MYH15 are shown (see all 3128)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs772354531,2
    C,F--108098718(+) TTCATG/TTTGTT 1 -- ds50011Minor allele frequency- T:0.13WA 118
    rs784953071,2
    F--108098786(+) CACACA/GTACCT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1903759951,2
    --108098932(+) GTCCTA/CTTGCC 1 -- ds50010--------
    rs1829600971,2
    --108099081(+) GGACTA/GCTGAA 1 -- ds50010--------
    rs1888435781,2
    --108099097(+) CTTACA/GGCGAC 1 -- ds50010--------
    rs1475591571,2
    C--108099148(+) ACTGAA/GTCCCT 1 -- ds50010--------
    rs1403427071,2
    --108099157(+) CTGAAC/TTAATC 1 -- ds50010--------
    rs1928232131,2
    --108099162(+) TTAATC/TGTCAA 1 -- ds50010--------
    rs98202511,2
    C,F,A,H--108099163(+) taatcG/ATCAAG 1 -- ds500115Minor allele frequency- A:0.04NS EA NA 1104
    rs614025321,2
    C,F--108099172(+) AGCTAC/TCCATA 1 -- ds50014Minor allele frequency- T:0.13WA NA EA 360

    HapMap Linkage Disequilibrium report for MYH15 (108099216 - 108248169 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MYH15:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv268776CNV Insertion20981092
    dgv5229n71CNV Loss21882294
    nsv3937CNV Loss18451855
    nsv829656CNV Loss17160897
    nsv829657CNV Gain17160897
    nsv829658CNV Gain17160897
    nsv526190CNV Gain19592680


    Human Gene Mutation Database (HGMD): MYH15
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609929    OMIM disorders: --

    3 diseases for MYH15:    About MalaCards
    myocarditis    coronary heart disease    myocardial infarction


    MYH15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MYH15
    Human Genome Epidemiology (HuGE) Navigator: MYH15 (4 documents)

    Export disorders for MYH15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYH15 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with MYH15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome wide association study for plasma levels of nat ural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA pr oject. (PubMed id 22443383)1, 4 Oudot-Mellakh T....Morange P.E. (2012)
    2. Polymorphisms associated with both noncardioembolic s troke and coronary heart disease: vienna stroke registry. (PubMed id 19752551)1, 4 Luke M.M....Mannhalter C. (2009)
    3. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. (2009)
    4. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (2008)
    5. Five common gene variants identify elevated genetic risk for coronary heart disease. (PubMed id 18073581)1, 4 Bare L.A....Boerwinkle E. (2007)
    6. Myosin gene mutation correlates with anatomical changes in the human lineage. (PubMed id 15042088)1, 3 Stedman H.H....Mitchell M.A. (2004)
    7. Evolution of sarcomeric myosin heavy chain genes: evi dence from fish. (PubMed id 15014174)1, 3 McGuigan K....Postlethwait J.H. (2004)
    8. Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family. (PubMed id 11919279)1, 2 Desjardins P.R....Stedman H.H. (2002)
    9. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
    10. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)1 Martins-de-Souza D....Bahn S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22989 HGNC: 31073 AceView: MYH15 Ensembl:ENSG00000144821 euGenes: HUgn22989
    ECgene: MYH15 Kegg: 22989 H-InvDB: MYH15

    (According to HUGE)
    About This Section
    HUGE: KIAA1000

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYH15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYH15 gene:
    Search GeneIP for patents involving MYH15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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