Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MYH15 Gene

protein-coding   GIFtS: 55
GCID: GC03M108108

Myosin, Heavy Chain 15

(Previous names: myosin, heavy polypeptide 15)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Myosin, Heavy Chain 151 2
Myosin, Heavy Polypeptide 151 2
myosin-152
KIAA10003
Myosin Heavy Chain 153

External Ids:    HGNC: 310731   Entrez Gene: 229892   Ensembl: ENSG000001448217   OMIM: 6099295   UniProtKB: Q9Y2K33   

Export aliases for MYH15 gene to outside databases

Previous GC identifers: GC03M109581 GC03M105472


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for MYH15 Gene:
MYH15 (myosin, heavy chain 15) is a protein-coding gene. Diseases associated with MYH15 include myocarditis, and coronary heart disease. GO annotations related to this gene include motor activity and actin binding. An important paralog of this gene is MYH8.

UniProtKB/Swiss-Prot: MYH15_HUMAN, Q9Y2K3
Function: Muscle contraction (By similarity)

summary for MYH15 Gene:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYH15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the MYH15 gene promoter:
         TBP   NF-1/L   ISGF-3   NF-1   HNF-1A   MEF-2A   S8   POU2F1   HNF-1   POU2F1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MYH15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYH15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.13   Ensembl cytogenetic band:  3q13.13   HGNC cytogenetic band: 3q13

MYH15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYH15 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M108108:  view genomic region     (about GC identifiers)

Start:
108,099,216 bp from pter      End:
108,248,169 bp from pter
Size:
148,954 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MYH15_HUMAN, Q9Y2K3 (See protein sequence)
Recommended Name: Myosin-15  
Size: 1946 amino acids; 224619 Da
Subunit: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain
subunits (MLC) and 2 regulatory light chain subunits (MLC-2) (By similarity)
Caution: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-15
(MYO15)
Sequence caution: Sequence=BAA76844.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Explore the universe of human proteins at neXtProt for MYH15: NX_Q9Y2K3

Explore proteomics data for MYH15 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYH15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055796.1  
    ENSEMBL proteins: 
     ENSP00000273353  
    Reactome Protein details: Q9Y2K3

    MYH15 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MYH15
    GenScript Custom Purified and Recombinant Proteins Services for MYH15
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MYH15

    MYH15 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MYH15
    OriGene Custom Antibody Services for MYH15
    Abcam antibodies for MYH15
    Cloud-Clone Corp. Antibodies for MYH15
    Search ThermoFisher Antibodies for MYH15
    LSBio Antibodies in human, mouse, rat for MYH15

    MYH15 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MYH15
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MYH15
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MYH15
    Cloud-Clone Corp. CLIAs for MYH15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    MYHII: Myosins / Myosin superfamily : Class II

    Selected InterPro protein domains (see all 6):
     IPR027401 Myosin-like_IQ_dom
     IPR015650 Myosin_1/23/4/6/7/8/13/15
     IPR004009 Myosin_N
     IPR027417 P-loop_NTPase
     IPR002928 Myosin_tail

    Graphical View of Domain Structure for InterPro Entry Q9Y2K3

    ProtoNet protein and cluster: Q9Y2K3

    3 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB002928 Myosin tail
    IPB004009 Myosin N-terminal SH3-like domain


    UniProtKB/Swiss-Prot: MYH15_HUMAN, Q9Y2K3
    Domain: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of
    4 heptapeptides, characteristic for alpha-helical coiled coils (By similarity)
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 myosin head-like domain


    MYH15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYH15_HUMAN, Q9Y2K3
    Function: Muscle contraction (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003774motor activity IEA--
    GO:0003779actin binding IEA--
    GO:0005516calmodulin binding IEA--
    GO:0005524ATP binding IEA--
         
    MYH15 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MYH15:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYH15
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYH15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYH15
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYH15

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MYH15 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate MYH15:
    hsa-miR-3607-5p hsa-miR-576-5p hsa-miR-3613-3p hsa-miR-944 hsa-miR-664
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MYH15
    Predesigned siRNA for gene silencing in human, mouse, rat MYH15

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MYH15

    Clone
    Products:
         
    OriGene clones in human, mouse for MYH15 (see all 5)
    OriGene ORF clones in mouse, rat for MYH15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYH15 (NM_014981)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYH15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYH15

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MYH15
    Browse ESI BIO Cell Lines and PureStem Progenitors for MYH15 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MYH15_HUMAN, Q9Y2K3: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol2
    endoplasmic reticulum1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016459myosin complex ----
    GO:0030016myofibril IEA--
    GO:0032982myosin filament IEA--

    MYH15 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MYH15 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    2Cell adhesion Integrin mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Development MAG dependent inhibition of neurite outgrowth0.46
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cell adhesion Tight junctions0.33
    3Clathrin derived vesicle budding
    Membrane Trafficking0.32
    Translocation of GLUT4 to the Plasma Membrane0.32
    4Tight junction
    Tight junction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYH15 (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions

    Selected GeneGo (Thomson Reuters) Pathways for MYH15 (see all 6)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Tight junctions

    1 Reactome Pathway for MYH15
        Translocation of GLUT4 to the plasma membrane


    1 Kegg Pathway  (Kegg details for MYH15):
        Tight junction


    MYH15 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYH15
    Interactions:

        Search GeneGlobe Interaction Network for MYH15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYH15 (Q9Y2K33 ENSP000002733534) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DAXXQ9UER73I2D: score=2 
    ENSG00000206206Q9UER73I2D: score=2 
    ENSG00000206279Q9UER73I2D: score=2 
    ENSG00000227046Q9UER73I2D: score=2 
    ENSG00000231617Q9UER73I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MYH15 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BTSSelective inhibitor of skeletal muscle myosin II ATPase activity[1576-37-0]
    (R)-(+)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)[1177356-70-5]
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)[856925-71-8]
    (+-)-BlebbistatinSelective inhibitor of myosin II ATPase activity[674289-55-5]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MYH15 gene: 
    NM_014981.1  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273353(uc003dxa.1) ENST00000478998 ENST00000495753
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MYH15 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate MYH15:
    hsa-miR-3607-5p hsa-miR-576-5p hsa-miR-3613-3p hsa-miR-944 hsa-miR-664
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MYH15
    Predesigned siRNA for gene silencing in human, mouse, rat MYH15
    Clone
    Products:
         
    OriGene clones in human, mouse for MYH15 (see all 5)
    OriGene ORF clones in mouse, rat for MYH15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYH15 (NM_014981)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYH15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYH15
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MYH15
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYH15
      QuantiTect SYBR Green Assays in human, mouse, rat MYH15
      QuantiFast Probe-based Assays in human, mouse, rat MYH15

    19 AceView cDNA sequences:

    AK055436 AB023217 BU167145 BX282440 CB135993 BM474348 AL705986 AK126801 
    AK097806 AW450042 AL039898 BF062942 AW148535 CF139878 BQ368360 BE798025 
    AV721706 AI720204 T10409 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MYH15 expression in normal human tissues (normalized intensities)      MYH15 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGATTAAA
    MYH15 Expression
    About this image


    MYH15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Skeletal Muscle (Muscoskeletal System)
             Multinuclear Myocyte Extraocular Muscles
    MYH15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYH15 Protein Expression
        Custom PCR Arrays for MYH15
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MYH15
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYH15
    QuantiTect SYBR Green Assays in human, mouse, rat MYH15
    QuantiFast Probe-based Assays in human, mouse, rat MYH15
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYH15 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myh151 , 5 myosin, heavy chain 151, 5 82.1(n)1
    75.69(a)1
      16 (30.75 cM)5
    6677721  NM_001166210.11  NP_001159682.11 
     490574865 
    chicken
    (Gallus gallus)
    Aves MYH156
    Gallus gallus myosin, heavy chain 15 (MYH15), mRNA...
    71(a)
    1 ↔ 1
    1(86879998-86923778)
    lizard
    (Anolis carolinensis)
    Reptilia MYH156
    myosin, heavy chain 15
    64(a)
    1 ↔ 1
    3(169209421-169365919)
    fruit fly
    (Drosophila melanogaster)
    Insecta Mhc6
    Myosin heavy chain
    47(a)
    1 → many
    2L(16766737-16788766)
    worm
    (Caenorhabditis elegans)
    Secernentea myo-56
    unc-546
    (see all 6)
    Protein UNC-54 (unc-54) mRNA, complete cds
    (see all 6)
    43(a)
    43(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    V(8109051-8118130) WBGene00019064
    I(14855899-14863540) WBGene00006789
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MYO16
    Type II myosin heavy chain, required for wild-type...
    27(a)
    1 → many
    VIII(151666-157452) YHR023W


    ENSEMBL Gene Tree for MYH15 (if available)
    TreeFam Gene Tree for MYH15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MYH15 gene
    MYH82  MYH12  MYH22  MYH112  MYH142  MYH92  MYH102  MYH132  
    MYH7B2  MYH42  MYH32  MYH62  MYH72  
    Selected SIMAP similar genes for MYH15 using alignment to 3 protein entries:     MYH15_HUMAN (see all proteins) (see all similar genes):
    MYH7    MYH6    MYH4    MYH1    MYH13    MYH2
    MYH3    MYH8    MYH7B    MYH16    MYH9    MYH10
    MYH11    MYO5B    MYH14    MYO1D    MYO1A    DKFZp686A01173

    MYH15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MYH15 (see all 3128)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs772354531,2
    C,F--108098718(+) TTCATG/TTTGTT 1 -- ds50011Minor allele frequency- T:0.13WA 118
    rs784953071,2
    F--108098786(+) CACACA/GTACCT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1903759951,2
    --108098932(+) GTCCTA/CTTGCC 1 -- ds50010--------
    rs1829600971,2
    --108099081(+) GGACTA/GCTGAA 1 -- ds50010--------
    rs1888435781,2
    --108099097(+) CTTACA/GGCGAC 1 -- ds50010--------
    rs1475591571,2
    C--108099148(+) ACTGAA/GTCCCT 1 -- ds50010--------
    rs1403427071,2
    --108099157(+) CTGAAC/TTAATC 1 -- ds50010--------
    rs1928232131,2
    --108099162(+) TTAATC/TGTCAA 1 -- ds50010--------
    rs98202511,2
    C,F,A,H--108099163(+) taatcG/ATCAAG 1 -- ds500115Minor allele frequency- A:0.04NS EA NA 1104
    rs614025321,2
    C,F--108099172(+) AGCTAC/TCCATA 1 -- ds50014Minor allele frequency- T:0.13WA NA EA 360

    HapMap Linkage Disequilibrium report for MYH15 (108099216 - 108248169 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MYH15:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv268776CNV Insertion20981092
    dgv5229n71CNV Loss21882294
    nsv3937CNV Loss18451855
    nsv829656CNV Loss17160897
    nsv829657CNV Gain17160897
    nsv829658CNV Gain17160897
    nsv526190CNV Gain19592680

    Human Gene Mutation Database (HGMD): MYH15
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYH15
    DNA2.0 Custom Variant and Variant Library Synthesis for MYH15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609929    OMIM disorders: --

    3 diseases for MYH15:    About MalaCards
    myocarditis    coronary heart disease    myocardial infarction


    MYH15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MYH15
    Human Genome Epidemiology (HuGE) Navigator: MYH15 (4 documents)

    Export disorders for MYH15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MYH15 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with MYH15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project. (PubMed id 22443383)1, 4 Oudot-Mellakh T....Morange P.E. (Br. J. Haematol. 2012)
    2. Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry. (PubMed id 19752551)1, 4 Luke M.M....Mannhalter C. (Cerebrovasc. Dis. 2009)
    3. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)
    4. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008)
    5. Five common gene variants identify elevated genetic risk for coronary heart disease. (PubMed id 18073581)1, 4 Bare L.A....Boerwinkle E. (Genet. Med. 2007)
    6. Myosin gene mutation correlates with anatomical changes in the human lineage. (PubMed id 15042088)1, 3 Stedman H.H....Mitchell M.A. (Nature 2004)
    7. Evolution of sarcomeric myosin heavy chain genes: evidence from fish. (PubMed id 15014174)1, 3 McGuigan K....Postlethwait J.H. (Mol. Biol. Evol. 2004)
    8. Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family. (PubMed id 11919279)1, 2 Desjardins P.R....Stedman H.H. (Mol. Biol. Evol. 2002)
    9. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    10. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)1 Martins-de-Souza D....Bahn S. (J. Proteome Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 22989 HGNC: 31073 AceView: MYH15 Ensembl:ENSG00000144821 euGenes: HUgn22989
    ECgene: MYH15 Kegg: 22989 H-InvDB: MYH15

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1000

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MYH15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MYH15 gene:
    Search GeneIP for patents involving MYH15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MYH15   OriGene RNAi products in human, mouse, rat for MYH15  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MYH15  
     OriGene qSTAR qPCR primer pairs in human, mouse for MYH15   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MYH15   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MYH15   OriGene Custom Protein Services for MYH15  

     
     
     Block miRNA regulation of human, mouse, rat MYH15 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MYH15
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYH15 Predesigned siRNA for gene silencing in human, mouse, rat MYH15
     QuantiFast Probe-based Assays in human, mouse, rat MYH15 QuantiTect SYBR Green Assays in human, mouse, rat MYH15
     Custom PCR Arrays for MYH15 Search Chromatin IP Primers for MYH15
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYH15  Search GeneGlobe Interaction Network for MYH15
     Regulatory tfbs in MYH15 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MYH15 GenScript cDNA clones with any tag delivered in your preferred vector for MYH15
     GenScript Custom Assay Services for MYH15 GenScript Custom overexpressing Cell Line Services for MYH15
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for MYH15
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Biologicals
     Novus Tissue Slides
     Antibodies for MYH15
     See all of Abcam's Antibodies, Kits and Proteins for MYH15
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MYH15
     Antibodies for MYH15
     ELISAs for MYH15
     CLIAs for MYH15



     Browse ESI BIO Cell Lines and PureStem Progenitors for MYH15
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH15
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MYH15
     Browse SwitchGear Promoter luciferase reporter plasmids for MYH15
     Search ThermoFisher Antibodies for MYH15
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYH15
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYH15
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYH15
     LSBio Antibodies in human, mouse, rat for MYH15
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MYH15 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4