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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MYH15 Gene

protein-coding GIFtS: 56
GCID: GC03M108108

myosin, heavy chain 15

(Previous names: myosin, heavy polypeptide 15 )

Explore 4 diseases affiliated with
MYH15 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Myosin, Heavy Chain 15¹ ²
Myosin, Heavy Polypeptide 15¹ ²
KIAA1000¹ ³
Myosin-15¹
Myosin Heavy Chain 15³

External Ids:	HGNC: 31073¹	Entrez Gene: 22989²	Ensembl: ENSG00000144821⁷	OMIM: 609929⁵	UniProtKB: Q9Y2K3³

Export aliases for MYH15 gene to outside databases

Previous GC identifers: GC03M109581 GC03M105472

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MYH15_HUMAN, Q9Y2K3

Function: Muscle contraction (By similarity)

summary for MYH15:

Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding

and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),

almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain

that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts

with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory

myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.

Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is

involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a

contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by

intracellular Ca2+ concentrations.

Gene Wiki entry for MYH15

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MYH15 gene promoter:
TBP NF-1/L ISGF-3 NF-1 HNF-1A MEF-2A S8 POU2F1 HNF-1 POU2F1a
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for MYH15

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYH15

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.13 Ensembl cytogenetic band: 3q13.13 HGNC cytogenetic band: 3q13

MYH15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYH15 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M108108: view genomic region (about GC identifiers)

Start:	108,099,216 bp from pter	End:	108,248,169 bp from pter
Size:	148,954 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MYH15_HUMAN, Q9Y2K3 (See protein sequence)

Recommended Name: Myosin-15

Size: 1946 amino acids; 224619 Da

Subunit: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain

subunits (MLC) and 2 regulatory light chain subunits (MLC-2) (By similarity)

Subcellular location: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils

Caution: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-15

(MYO15)

Sequence caution: Sequence=BAA76844.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Explore the universe of human proteins at neXtProt for MYH15: NX_Q9Y2K3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y2K3

MYH15 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055796.1

ENSEMBL proteins:

ENSP00000273353

Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MYH15

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030016	myofibril	IEA	--
GO:0032982	myosin filament	IEA	--

MYH15 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for MYH15

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MYH15 for domains About GeneDecksing

4 InterPro domains/families:

IPR004009 Myosin_N

IPR002928 Myosin_tail

IPR015650 Myosin_1/23/4/7/8/13/15

IPR001609 Myosin_head_motor_dom

Graphical View of Domain Structure for InterPro Entry Q9Y2K3

ProtoNet protein and cluster: Q9Y2K3

3 Blocks protein families:

IPB000048 IQ calmodulin-binding region

IPB002928 Myosin tail

IPB004009 Myosin N-terminal SH3-like domain

UniProtKB/Swiss-Prot: MYH15_HUMAN, Q9Y2K3

Domain: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4

heptapeptides, characteristic for alpha-helical coiled coils (By similarity)

Similarity: Contains 1 IQ domain

Similarity: Contains 1 myosin head-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MYH15_HUMAN, Q9Y2K3

Function: Muscle contraction (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: MYH15 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYH15
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate MYH15:
		hsa-miR-3607-5p hsa-miR-576-5p hsa-miR-3613-3p hsa-miR-944 hsa-miR-664
		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH15

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003774	motor activity	IEA	--
GO:0003779	actin binding	IEA	--
GO:0005516	calmodulin binding	IEA	--
GO:0005524	ATP binding	IEA	--

MYH15 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MYH15:

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_Integrin-mediated cell adhesion and migration

	Cell adhesion_Integrin-mediated cell adhesion and migration	1.00			Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases	0.49
	Cell adhesion Integrin-mediated cell adhesion and migration	1.00			Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases	0.49

Immune response _CCR3 signaling in eosinophils

	Immune response _CCR3 signaling in eosinophils	1.00			Inhibitory action of Lipoxins on neutrophil migration	0.51
	Immune response CCR3 signaling in eosinophils	1.00

Cell adhesion Tight junctions

Cell adhesion Tight junctions

1.00

Cell adhesion_Tight junctions

0.99

Development MAG-dependent inhibition of neurite outgrowth

Development MAG-dependent inhibition of neurite outgrowth

1.00

Development_MAG-dependent inhibition of neurite outgrowth

0.87

Tight junction

Tight junction

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for MYH15

	Cell adhesion Integrin-mediated cell adhesion and migration
	Cell adhesion Tight junctions
	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
	Immune response CCR3 signaling in eosinophils
	Development MAG-dependent inhibition of neurite outgrowth

5/6 GeneGo (Thomson Reuters) Pathways for MYH15 (see all 6)

	Cell adhesion Integrin-mediated cell adhesion and migration
	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
	Inhibitory action of Lipoxins on neutrophil migration
	Immune response CCR3 signaling in eosinophils
	Cell adhesion Tight junctions

2 Kegg Pathways (Kegg details for MYH15):

	Tight junction
	Viral myocarditis

MYH15 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MYH15

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

5/23 Interacting proteins for MYH15 (Q9Y2K3³ ENSP00000273353⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DAXX	Q9UER7³	I2D: score=2
ACTB	ENSP00000349960⁴	STRING: ENSP00000349960
ACTG1	ENSP00000331514⁴	STRING: ENSP00000331514
CGN	ENSP00000271636⁴	STRING: ENSP00000271636
RHOA	ENSP00000400175⁴	STRING: ENSP00000400175

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for MYH15 available from Tocris Bioscience About this table

Compound	Action	CAS #
(R)-(+)-Blebbistatin	Selective inhibitor of myosin II. Inactive enantiomer of (�)-blebbistatin (Cat. No. 1760)	--
(S)-(-)-Blebbistatin	Selective inhibitor of myosin II. Active enantiomer of (�)-blebbistatin (Cat. No. 1760)	[856925-71-8]
(�)-Blebbistatin	Selective inhibitor of myosin II	[674289-55-5]

Search CenterWatch for drugs/clinical trials and news about MYH15

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MYH15 gene:

NM_014981.1

Unigene Cluster for MYH15:

Myosin, heavy chain 15

Hs.731060 [show with all ESTs]

Unigene Representative Sequence: AB023217

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000273353(uc003dxa.1) ENST00000478998 ENST00000495753

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYH15
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate MYH15:
		hsa-miR-3607-5p hsa-miR-576-5p hsa-miR-3613-3p hsa-miR-944 hsa-miR-664
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYH15 OriGene shRNA RFP: MYH15 OriGene siRNA: MYH15
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYH15

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYH15 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYH15 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MYH15 (NM_014981)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYH15
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYH15

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYH15
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYH15

Additional cDNA sequence:

AB023217.3 AK055436.1 AK126801.1

4 DOTS entries:

DT.91734160 DT.75122754 DT.91734159 DT.97787955

19 AceView cDNA sequences:

AB023217 BU167145 BX282440 AK055436 AW450042 AK097806 CB135993 BF062942

AK126801 AL705986 AL039898 BM474348 CF139878 AW148535 AV721706 BQ368360

BE798025 AI720204 T10409

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MYH15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAGATTAAA

About this image

MYH15 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Skeletal Muscle

Extraocular Muscles

Multinuclear Myocyte

Selective marker (cell-identifying gene)

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MYH15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MYH15

SOURCE GeneReport for Unigene cluster: Hs.731060

SABiosciences Custom PCR Arrays for MYH15

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH15

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MYH15 gene from 5/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	Q91377_CHICK⁶	myosin heavy chain 6	70(a)	1 ↔ 1	1(90776484-90820265)
lizard (Anolis carolinensis)	Reptilia	MYH15⁶	--	64(a)	1 ↔ 1	3(169213316-169365919)
zebrafish (Danio rerio)	Actinopterygii	CABZ01102039.1⁶	--	39(a)	possible ortholog	12(67545-75100)
fruit fly (Drosophila melanogaster)	Insecta	Mhc⁶	Myosin heavy chain	46(a)	1 → many	2L(16766737-16788766)
worm (Caenorhabditis elegans)	Secernentea	unc-54⁶ myo-3⁶ (see all 6)	Myosin-3 (see all 6)	43(a) 42(a) (see all 6)	many ↔ many many ↔ many (see all 6)	I(14855888-14863529) V(12226797-12234324)

ENSEMBL Gene Tree for MYH15 (if available)
TreeFam Gene Tree for MYH15 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MYH15 gene

MYH8² MYH1² MYH2² MYH11² MYH14² MYH9² MYH13² MYH10²

MYH7B² MYH4² MYH3² MYH6² MYH7²

18/20 SIMAP similar genes for MYH15 using alignment to 3 protein entries: MYH15_HUMAN (see all proteins) (see all similar genes):

MYH7 MYH6 MYH4 MYH1 MYH13 MYH2

MYH3 MYH8 MYH7B MYH16 MYH9 MYH11

MYH10 MYO5B MYH14 MYO1D MYO1A DKFZp686A01173

MYH15 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77235453^1,2	F,	--	108098718(+)	`TTCATG/TTTGTT`	1	--	ds500¹		1		WA	118
rs78495307^1,2	F,	--	108098786(+)	`CACACA/GTACCT`	1	--	ds500¹		1		WA	118
rs190375995^1,2		--	108098932(+)	`GTCCTA/CTTGCC`	1	--	ds500¹		0	--	--	--	--
rs182960097^1,2		--	108099081(+)	`GGACTA/GCTGAA`	1	--	ds500¹		0	--	--	--	--
rs188843578^1,2		--	108099097(+)	`CTTACA/GGCGAC`	1	--	ds500¹		0	--	--	--	--
rs147559157^1,2		--	108099148(+)	`ACTGAA/GTCCCT`	1	--	ds500¹		0	--	--	--	--
rs140342707^1,2		--	108099157(+)	`CTGAAC/TTAATC`	1	--	ds500¹		0	--	--	--	--
rs192823213^1,2		--	108099162(+)	`TTAATC/TGTCAA`	1	--	ds500¹		0	--	--	--	--
rs9820251^1,2	C,F,A,H,	--	108099163(+)	`TAATCG/ATCAAG`	1	--	ds500¹		15		NS EA NA	1104
rs61402532^1,2	C,	--	108099172(+)	`AGCTAC/TCCATA`	1	--	ds500¹		4		WA NA EA	360

HapMap Linkage Disequilibrium report for MYH15 (108099216 - 108248169 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MYH15: --
Human Gene Mutation Database (HGMD): MYH15

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYH15

DNA2.0 Custom Variant and Variant Library Synthesis for MYH15

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MYH15 for disorders           About GeneDecksing

OMIM gene information: 609929    OMIM disorders: --

4 diseases for MYH15:    About MalaCards

coronary heart disease myocardial infarction hermaphroditism pharyngitis

Human Genome Epidemiology (HuGE) Navigator: MYH15 (4 documents)

Export disorders for MYH15 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MYH15 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with MYH15)

Utopia: connect your pdf to the dynamic
world of online information

Myosin gene mutation correlates with anatomical changes in the human lineage. (PubMed id 15042088)^{1, 3} Stedman H.H....Mitchell M.A. (2004)
Evolution of sarcomeric myosin heavy chain genes: evi dence from fish. (PubMed id 15014174)^{1, 3} McGuigan K....Postlethwait J.H. (2004)
Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family. (PubMed id 11919279)^{1, 2} Desjardins P.R....Stedman H.H. (2002)
Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)^{1, 2} Nagase T.... Ohara O. (1999)
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)¹ Martins-de-Souza D....Bahn S. (2012)
Genome wide association study for plasma levels of nat ural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA pr oject. (PubMed id 22443383)¹ Oudot-Mellakh T....Morange P.E. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Two novel/ancient myosins in mammalian skeletal muscl es: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles . (PubMed id 19948655)¹ Rossi A.C....Schiaffino S. (2010)
Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)¹ Luke M.M....Psaty B.M. (2009)
Polymorphisms associated with both noncardioembolic s troke and coronary heart disease: vienna stroke registry. (PubMed id 19752551)¹ Luke M.M....Mannhalter C. (2009)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 22989	HGNC: 31073	AceView: MYH15	Ensembl:ENSG00000144821	euGenes: HUgn22989
ECgene: MYH15	Kegg: 22989	H-InvDB: MYH15

(According to HUGE)
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HUGE: KIAA1000

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MYH15	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MYH15 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MYH15 gene:
Search GeneIP for patents involving MYH15

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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myosin, heavy chain 15

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myosin, heavy chain 15

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