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Aliases for MYH13 Gene

Aliases for MYH13 Gene

  • Myosin, Heavy Chain 13, Skeletal Muscle 2 3
  • Myosin Heavy Chain, Skeletal Muscle, Extraocular 3 4
  • Myosin Heavy Chain, Skeletal Muscle, Laryngeal 3 4
  • Myosin, Heavy Polypeptide 13, Skeletal Muscle 2 3
  • Extraocular Muscle Myosin Heavy Chain 2 3
  • Extraocular Myosin Heavy Chain 2 3
  • Myosin Heavy Chain 13 3 4
  • Superfast Myosin 3 4
  • MyHC-IIL 3 4
  • MyHC-Eo 3 4
  • Myosin-13 3

External Ids for MYH13 Gene

Previous GeneCards Identifiers for MYH13 Gene

  • GC17M010570
  • GC17M011319
  • GC17M010147
  • GC17M010404
  • GC17M010144

Summaries for MYH13 Gene

GeneCards Summary for MYH13 Gene

MYH13 (Myosin, Heavy Chain 13, Skeletal Muscle) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and ERK Signaling. GO annotations related to this gene include actin binding and microfilament motor activity. An important paralog of this gene is MYH4.

UniProtKB/Swiss-Prot for MYH13 Gene

  • Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles.

Tocris Summary for MYH13 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name), almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II. Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by intracellular Ca2+ concentrations.

Gene Wiki entry for MYH13 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYH13 Gene

Genomics for MYH13 Gene

Regulatory Elements for MYH13 Gene

Genomic Location for MYH13 Gene

Start:
10,298,084 bp from pter
End:
10,373,130 bp from pter
Size:
75,047 bases
Orientation:
Minus strand

Genomic View for MYH13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYH13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYH13 Gene

Proteins for MYH13 Gene

  • Protein details for MYH13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKX3-MYH13_HUMAN
    Recommended name:
    Myosin-13
    Protein Accession:
    Q9UKX3
    Secondary Accessions:
    • O95252
    • Q9P0U8

    Protein attributes for MYH13 Gene

    Size:
    1938 amino acids
    Molecular mass:
    223605 Da
    Quaternary structure:
    • Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2)

neXtProt entry for MYH13 Gene

Proteomics data for MYH13 Gene at MOPED

Post-translational modifications for MYH13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYH13 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MYH13 Gene

Domains for MYH13 Gene

Gene Families for MYH13 Gene

HGNC:
  • MYHII :Myosins / Myosin superfamily : Class II

Graphical View of Domain Structure for InterPro Entry

Q9UKX3

UniProtKB/Swiss-Prot:

MYH13_HUMAN :
  • Q9UKX3
Domain:
  • The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils
  • Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2)
  • The head-like domain S1 exhibits a much faster ATP-induced detachment from actin, and ADP affinity is more than 3-fold weaker than other myosins
  • Contains 1 IQ domain.
  • Contains 1 myosin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYH13: view

Function for MYH13 Gene

Molecular function for MYH13 Gene

GENATLAS Biochemistry: myosin,motor contractile protein moving towards the "plus" end of actin track,heavy chain (EO myosin),expressed in hyperfast extra ocular and laryngeal muscles
UniProtKB/Swiss-Prot Function: Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles.

Gene Ontology (GO) - Molecular Function for MYH13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000146 microfilament motor activity TAS 10388558
GO:0003774 motor activity --
GO:0003779 actin binding IEA --
GO:0005515 protein binding --
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with MYH13: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYH13

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MYH13 Gene

Localization for MYH13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYH13 Gene

Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYH13 Gene COMPARTMENTS Subcellular localization image for MYH13 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MYH13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005859 muscle myosin complex TAS 10388558
GO:0016459 myosin complex --
GO:0030016 myofibril IEA --
GO:0032982 myosin filament IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with MYH13: view

Pathways for MYH13 Gene

genes like me logo Genes that share pathways with MYH13: view

Gene Ontology (GO) - Biological Process for MYH13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 10388558
GO:0008152 metabolic process TAS 10388558
GO:0009267 cellular response to starvation IEA --
genes like me logo Genes that share ontologies with MYH13: view

Compounds for MYH13 Gene

(4) Tocris Compounds for MYH13 Gene

Compound Action Cas Number
(�)-Blebbistatin Selective inhibitor of myosin II ATPase activity [674289-55-5]
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (�)-blebbistatin (Cat. No. 1760) [1177356-70-5]
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (�)-blebbistatin (Cat. No. 1760) [856925-71-8]
BTS Selective inhibitor of skeletal muscle myosin II ATPase activity [1576-37-0]
genes like me logo Genes that share compounds with MYH13: view

Transcripts for MYH13 Gene

mRNA/cDNA for MYH13 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYH13 Gene

Myosin, heavy chain 13, skeletal muscle:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYH13

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MYH13

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYH13 Gene

No ASD Table

Relevant External Links for MYH13 Gene

GeneLoc Exon Structure for
MYH13
ECgene alternative splicing isoforms for
MYH13

Expression for MYH13 Gene

mRNA expression in normal human tissues for MYH13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYH13 Gene

This gene is overexpressed in Muscle - Skeletal (32.6) and Stomach (8.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYH13 Gene

SOURCE GeneReport for Unigene cluster for MYH13 Gene Hs.711142

mRNA Expression by UniProt/SwissProt for MYH13 Gene

Q9UKX3-MYH13_HUMAN
Tissue specificity: Specifically expressed in extraocular and laryngeal muscles.
genes like me logo Genes that share expressions with MYH13: view

In Situ Assay Products

Orthologs for MYH13 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYH13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYH13 35
  • 99.31 (n)
  • 99.59 (a)
MYH13 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYH13 35
  • 90.33 (n)
  • 94.36 (a)
MYH13 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYH13 35
  • 89.92 (n)
  • 94.79 (a)
MYH13 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myh13 35
  • 89.35 (n)
  • 96.08 (a)
Myh13 16
Myh13 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
-- 36
  • 83 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Myh13 35
  • 87.29 (n)
  • 92.02 (a)
chicken
(Gallus gallus)
Aves MYH13 35
  • 78.65 (n)
  • 84.73 (a)
MYH13 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYH13 36
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mhc 37
  • 48 (a)
Prm 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea myo-3 37
  • 46 (a)
hcp-1 37
  • 21 (a)
F58G4.1 37
  • 46 (a)
F45G2.2 37
  • 44 (a)
hcp-2 37
  • 21 (a)
Y11D7A.14 37
  • 29 (a)
Species with no ortholog for MYH13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MYH13 Gene

ENSEMBL:
Gene Tree for MYH13 (if available)
TreeFam:
Gene Tree for MYH13 (if available)

Paralogs for MYH13 Gene

Paralogs for MYH13 Gene

Pseudogenes.org Pseudogenes for MYH13 Gene

genes like me logo Genes that share paralogs with MYH13: view

Variants for MYH13 Gene

Sequence variations from dbSNP and Humsavar for MYH13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs732426 -- 10,371,069(+) AATCT(A/G)CCTTT intron-variant
rs751155 -- 10,314,502(+) AGCCC(A/G)CTCCT intron-variant
rs933366 -- 10,346,112(+) TCATG(C/T)TGTTC intron-variant
rs1071980 -- 10,354,837(-) AAAAA(A/C/G)CAACC intron-variant
rs1548646 -- 10,338,990(+) GCCAC(C/T)GTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYH13 Gene

Variant ID Type Subtype PubMed ID
nsv907673 CNV Gain 21882294
nsv520771 CNV Gain+Loss 19592680
nsv907679 CNV Gain 21882294
nsv457667 CNV Loss 19166990
esv2648260 CNV Deletion 19546169
esv2673102 CNV Deletion 23128226
nsv827883 CNV Loss 20364138
esv22034 CNV Gain 19812545
nsv833366 CNV Gain 17160897

Relevant External Links for MYH13 Gene

HapMap Linkage Disequilibrium report
MYH13
Human Gene Mutation Database (HGMD)
MYH13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYH13 Gene

Disorders for MYH13 Gene

Relevant External Links for MYH13

Genetic Association Database (GAD)
MYH13
Human Genome Epidemiology (HuGE) Navigator
MYH13
genes like me logo Genes that share disorders with MYH13: view

No data available for UniProtKB/Swiss-Prot for MYH13 Gene

Publications for MYH13 Gene

  1. The human extraocular muscle myosin heavy chain gene (MYH13) maps to the cluster of fast and developmental myosin genes on chromosome 17. (PMID: 9806854) Winters L.M. … Schachat F. (Genomics 1998) 2 3 4 23
  2. Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity. (PMID: 10388558) Weiss A. … Leinwand L.A. (J. Mol. Biol. 1999) 3 4
  3. Phylogenetic implications of the superfast myosin in extraocular muscles. (PMID: 12110653) Schachat F. … Briggs M.M. (J. Exp. Biol. 2002) 3 4
  4. Assessment of Alzheimer's disease case-control associations using family-based methods. (PMID: 18830724) Schjeide B.M. … Bertram L. (Neurogenetics 2009) 3 48
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48

Products for MYH13 Gene

Sources for MYH13 Gene

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