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MYH13 Gene

protein-coding   GIFtS: 59
GCID: GC17M010201

Myosin, Heavy Chain 13, Skeletal Muscle

(Previous names: myosin, heavy polypeptide 13, skeletal muscle)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin, Heavy Chain 13, Skeletal Muscle1 2     Myosin Heavy Chain, Skeletal Muscle, Laryngeal2 3
Myosin, Heavy Polypeptide 13, Skeletal Muscle1 2     Superfast Myosin2 3
Extraocular Muscle Myosin Heavy Chain1 2     MyHC-IIL2 3
Extraocular Myosin Heavy Chain1 2     MyHC-eo2
Myosin Heavy Chain 132 3     myosin-132
Myosin Heavy Chain, Skeletal Muscle, Extraocular2 3     MyHC-EO3

External Ids:    HGNC: 75711   Entrez Gene: 87352   Ensembl: ENSG000000067887   OMIM: 6034875   UniProtKB: Q9UKX33   

Export aliases for MYH13 gene to outside databases

Previous GC identifers: GC17M010570 GC17M011319 GC17M010147 GC17M010404 GC17M010144


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYH13 Gene:
MYH13 (myosin, heavy chain 13, skeletal muscle) is a protein-coding gene. GO annotations related to this gene include microfilament motor activity and actin binding. An important paralog of this gene is MYH8.

UniProtKB/Swiss-Prot: MYH13_HUMAN, Q9UKX3
Function: Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated
muscles

summary for MYH13 Gene:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYH13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MYH13 gene promoter:
         HOXA9B   HOXA9   Lmo2   NF-AT   IRF-2   FOXO1a   Meis-1a   NF-AT1   Meis-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYH13 promoter sequence
   Search Chromatin IP Primers for MYH13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYH13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13

MYH13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYH13 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M010201:  view genomic region     (about GC identifiers)

Start:
10,201,401 bp from pter      End:
10,276,447 bp from pter
Size:
75,047 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MYH13_HUMAN, Q9UKX3 (See protein sequence)
Recommended Name: Myosin-13  
Size: 1938 amino acids; 223605 Da
Subunit: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain
subunits (MLC) and 2 regulatory light chain subunits (MLC-2)
Secondary accessions: O95252 Q9P0U8

Explore the universe of human proteins at neXtProt for MYH13: NX_Q9UKX3

Explore proteomics data for MYH13 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYH13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003793.2  
    ENSEMBL proteins: 
     ENSP00000404570   ENSP00000252172  
    Reactome Protein details: Q9UKX3

    MYH13 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MYH13

     
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    antibodies-online peptides for MYH13

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    antibodies-online antibodies for MYH13 (3 products) 

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    antibodies-online kits for MYH13 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MYHII: Myosins / Myosin superfamily : Class II

    Selected InterPro protein domains (see all 7):
     IPR027401 Myosin-like_IQ_dom
     IPR015650 Myosin_1/23/4/6/7/8/13/15
     IPR004009 Myosin_N
     IPR027417 P-loop_NTPase
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry Q9UKX3

    ProtoNet protein and cluster: Q9UKX3

    3 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB002928 Myosin tail
    IPB004009 Myosin N-terminal SH3-like domain


    UniProtKB/Swiss-Prot: MYH13_HUMAN, Q9UKX3
    Domain: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of
    4 heptapeptides, characteristic for alpha-helical coiled coils
    Domain: Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can
    later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2)
    Domain: The head-like domain S1 exhibits a much faster ATP-induced detachment from actin, and ADP affinity is more
    than 3-fold weaker than other myosins
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 myosin head-like domain


    Find genes that share domains with MYH13           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYH13_HUMAN, Q9UKX3
    Function: Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated
    muscles

         Genatlas biochemistry entry for MYH13:
    myosin,motor contractile protein moving towards the "plus" end of actin track,heavy chain (EO myosin),expressed in
    hyperfast extra ocular and laryngeal muscles

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000146microfilament motor activity TAS10388558
    GO:0003774motor activity ----
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
    GO:0005516calmodulin binding IEA--
         
    Find genes that share ontologies with MYH13           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MYH13

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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYH13_HUMAN, Q9UKX3: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005859muscle myosin complex TAS10388558
    GO:0016459myosin complex ----
    GO:0030016myofibril IEA--
    GO:0032982myosin filament IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with MYH13           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYH13 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    2Cell adhesion Integrin mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Development MAG dependent inhibition of neurite outgrowth0.46
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cell adhesion Tight junctions0.33
    3PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35
    5RhoGDI Pathway
    Fc-GammaR-Mediated Phagocytosis in Macrophages0.33
    RhoGDI Pathway0.33


    Find genes that share SuperPaths with MYH13           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYH13 (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions

    Selected GeneGo (Thomson Reuters) Pathways for MYH13 (see all 6)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Tight junctions

    1 Reactome Pathway for MYH13
        Translocation of GLUT4 to the plasma membrane


    1 Kegg Pathway  (Kegg details for MYH13):
        Tight junction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYH13
    Interactions:

        Search GeneGlobe Interaction Network for MYH13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYH13 (Q9UKX32, 3 ENSP000002521724) via UniProtKB, MINT, STRING, and/or I2D (see all 157)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAQP273482, 3, ENSP000002380814MINT-7899812 MINT-7900157 I2D: score=1 STRING: ENSP00000238081
    YWHAZP631042, ENSP000003095034MINT-7899812 MINT-7900157 STRING: ENSP00000309503
    MYH9P355792, ENSP000002161814MINT-7899812 MINT-7900157 STRING: ENSP00000216181
    MYL3P085902, ENSP000002923274MINT-7899812 MINT-7900157 STRING: ENSP00000292327
    ACTBP607092, ENSP000003499604MINT-7899812 MINT-7900157 STRING: ENSP00000349960
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction TAS10388558
    GO:0008152metabolic process TAS10388558
    GO:0009267cellular response to starvation IEA--

    Find genes that share ontologies with MYH13           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MYH13 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BTSSelective inhibitor of skeletal muscle myosin II ATPase activity[1576-37-0]
    (R)-(+)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)[1177356-70-5]
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)[856925-71-8]
    (+-)-BlebbistatinSelective inhibitor of myosin II ATPase activity[674289-55-5]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYH13 gene: 
    NM_003802.2  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418404 ENST00000252172(uc002gmk.1 uc010vve.1 uc010vvf.1)

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    2 AceView cDNA sequences:

    AF111782 NM_003802 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYH13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACACCTCC
    MYH13 Expression
    About this image


    MYH13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)
             Multinuclear Myocyte Extraocular Muscles
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)
             Cerebral Cortex
    MYH13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYH13 Protein Expression

    UniProtKB/Swiss-Prot: MYH13_HUMAN, Q9UKX3
    Tissue specificity: Specifically expressed in extraocular and laryngeal muscles

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MYH13 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myh131 , 5 myosin, heavy polypeptide 13, skeletal muscle1, 5 89.35(n)1
    96.08(a)1
      11 (40.85 cM)5
    5447911  NM_001081250.11  NP_001074719.11 
     673216585 
    chicken
    (Gallus gallus)
    Aves MYH131 myosin, heavy chain 13, skeletal muscle 78.65(n)
    84.73(a)
      768487  XM_001231455.2  XP_001231456.2 
    lizard
    (Anolis carolinensis)
    Reptilia MYH136
    myosin, heavy chain 13, skeletal muscle
    86(a)
    1 ↔ 1
    2(109072753-109100735)


    ENSEMBL Gene Tree for MYH13 (if available)
    TreeFam Gene Tree for MYH13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYH13 gene
    MYH82  MYH12  MYH22  MYH112  MYH142  MYH92  MYH102  MYH7B2  
    MYH42  MYH32  MYH152  MYH62  MYH72  
    Selected SIMAP similar genes for MYH13 using alignment to 1 protein entry:     MYH13_HUMAN(see all similar genes):
    MYH4    MYH2    MYH3    MYH8    MYH6    MYH7
    MYH1    alpha-MHC    MYH15    MYH7B    MYH16    MYH9
    MYH11    MYO10    MYH10    MYO5B    MYH14    MYO5C

    Find genes that share paralogs with MYH13           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MYH13
    PGOHUM00000263185


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYH13 (see all 1852)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs755987071,2
    C--10203694(+) GTCCGA/GCCTGG 1 -- ds50010--------
    rs1378551871,2
    C--10203805(+) ATGCC-/CAG   
       TAGTG
    CAGTA
    1 -- ds50010--------
    rs1908472991,2
    --10203875(+) GTTGTA/GCCAAT 1 -- ds50010--------
    rs1510723791,2
    C--10204177(+) GAGCC-/GGGAAT 1 -- ds50010--------
    rs1833474411,2
    C--10204233(+) CTCTCA/GGAGGT 1 -- ut310--------
    rs1995374631,2
    C--10204308(+) TGTACA/GTAGGA 1 -- int10--------
    rs768653021,2
    C,F--10204401(+) AATGGC/TGTTGT 1 -- int11Minor allele frequency- T:0.05NA 120
    rs1180574311,2
    F--10204461(+) ACAAAC/TGCCCT 1 -- int11Minor allele frequency- T:0.01NA 120
    rs116522441,2
    C,H--10204562(+) CTGGAA/CCCACA 1 -- int16Minor allele frequency- C:0.00NS EA NA 422
    rs1488377371,2
    --10204674(+) ACTCCC/TCCGGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for MYH13 (10201401 - 10276447 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for MYH13:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2648260CNV Deletion19546169
    esv2673102CNV Deletion23128226
    nsv827883CNV Loss20364138
    nsv457667CNV Loss19166990
    nsv907679CNV Gain21882294
    esv22034CNV Gain19812545
    nsv833366CNV Gain17160897
    nsv907673CNV Gain21882294
    nsv520771CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): MYH13
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYH13
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603487    OMIM disorders: --


    Find genes that share disorders with MYH13           About GenesLikeMe

    Genetic Association Database (GAD): MYH13
    Human Genome Epidemiology (HuGE) Navigator: MYH13 (5 documents)

    Export disorders for MYH13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYH13 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with MYH13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human extraocular muscle myosin heavy chain gene (MYH13) maps to the cluster of fast and developmental myosin genes on chromosome 17. (PubMed id 9806854)1, 2, 3, 9 Winters L.M.... Schachat F. (Genomics 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Assessment of Alzheimer's disease case-control associations using family-based methods. (PubMed id 18830724)1, 4 Schjeide B.M....Bertram L. (Neurogenetics 2009)
    4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    5. Phylogenetic implications of the superfast myosin in extraocular muscles. (PubMed id 12110653)1, 2 Schachat F. and Briggs M.M. (J. Exp. Biol. 2002)
    6. Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity. (PubMed id 10388558)1, 2 Weiss A.... Leinwand L.A. (J. Mol. Biol. 1999)
    7. The superfast human extraocular myosin is kinetically distinct from the fast skeletal IIa, IIb, and IId isoforms. (PubMed id 23908353)2 Bloemink M.J.... Geeves M.A. (J. Biol. Chem. 2013)
    8. Slow skeletal muscle myosin-binding protein-C (MyBPC1) mediates recruitment of muscle-type creatine kinase (CK) to myosin. (PubMed id 21426302)1 Chen Z....Zhou H.M. (Biochem. J. 2011)
    9. Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. (PubMed id 20618440)1 Pozuelo-Rubio M. (FEBS J. 2010)
    10. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8735 HGNC: 7571 AceView: MYH13 Ensembl:ENSG00000006788 euGenes: HUgn8735
    ECgene: MYH13 Kegg: 8735 H-InvDB: MYH13

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYH13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYH13 gene:
    Search GeneIP for patents involving MYH13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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