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Aliases for MYH13 Gene

Aliases for MYH13 Gene

  • Myosin, Heavy Chain 13, Skeletal Muscle 2 3 5
  • Myosin Heavy Chain, Skeletal Muscle, Extraocular 3 4
  • Myosin Heavy Chain, Skeletal Muscle, Laryngeal 3 4
  • Myosin, Heavy Polypeptide 13, Skeletal Muscle 2 3
  • Extraocular Muscle Myosin Heavy Chain 2 3
  • Extraocular Myosin Heavy Chain 2 3
  • Myosin Heavy Chain 13 3 4
  • Superfast Myosin 3 4
  • MyHC-IIL 3 4
  • MyHC-Eo 3 4

External Ids for MYH13 Gene

Previous GeneCards Identifiers for MYH13 Gene

  • GC17M010570
  • GC17M011319
  • GC17M010147
  • GC17M010404
  • GC17M010144

Summaries for MYH13 Gene

GeneCards Summary for MYH13 Gene

MYH13 (Myosin, Heavy Chain 13, Skeletal Muscle) is a Protein Coding gene. Among its related pathways are Tight junction and Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYH4.

UniProtKB/Swiss-Prot for MYH13 Gene

  • Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles.

Tocris Summary for MYH13 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.

Gene Wiki entry for MYH13 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYH13 Gene

Genomics for MYH13 Gene

Regulatory Elements for MYH13 Gene

Enhancers for MYH13 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MYH13 on UCSC Golden Path with GeneCards custom track

Genomic Location for MYH13 Gene

Chromosome:
17
Start:
10,298,084 bp from pter
End:
10,373,130 bp from pter
Size:
75,047 bases
Orientation:
Minus strand

Genomic View for MYH13 Gene

Genes around MYH13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYH13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYH13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYH13 Gene

Proteins for MYH13 Gene

  • Protein details for MYH13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKX3-MYH13_HUMAN
    Recommended name:
    Myosin-13
    Protein Accession:
    Q9UKX3
    Secondary Accessions:
    • O95252
    • Q9P0U8

    Protein attributes for MYH13 Gene

    Size:
    1938 amino acids
    Molecular mass:
    223605 Da
    Quaternary structure:
    • Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

neXtProt entry for MYH13 Gene

Proteomics data for MYH13 Gene at MOPED

Post-translational modifications for MYH13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYH13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYH13 Gene

Domains & Families for MYH13 Gene

Gene Families for MYH13 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKX3

UniProtKB/Swiss-Prot:

MYH13_HUMAN :
  • The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
  • Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
  • The head-like domain S1 exhibits a much faster ATP-induced detachment from actin, and ADP affinity is more than 3-fold weaker than other myosins.
  • Contains 1 IQ domain.
  • Contains 1 myosin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYH13: view

Function for MYH13 Gene

Molecular function for MYH13 Gene

GENATLAS Biochemistry:
myosin,motor contractile protein moving towards the "plus" end of actin track,heavy chain (EO myosin),expressed in hyperfast extra ocular and laryngeal muscles
UniProtKB/Swiss-Prot Function:
Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles.

Gene Ontology (GO) - Molecular Function for MYH13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000146 microfilament motor activity TAS 10388558
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with MYH13: view
genes like me logo Genes that share phenotypes with MYH13: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYH13 Gene

Localization for MYH13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYH13 Gene

Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYH13 Gene COMPARTMENTS Subcellular localization image for MYH13 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
cytosol 3
nucleus 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for MYH13 Gene

Pathways & Interactions for MYH13 Gene

genes like me logo Genes that share pathways with MYH13: view

Gene Ontology (GO) - Biological Process for MYH13 Gene

None

No data available for SIGNOR curated interactions for MYH13 Gene

Drugs & Compounds for MYH13 Gene

(5) Additional Compounds for MYH13 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-Blebbistatin
674289-55-5
(R)-(+)-Blebbistatin
1177356-70-5
(S)-(-)-Blebbistatin
856925-71-8
ML 9 hydrochloride
105637-50-1
W-7 hydrochloride
61714-27-0

(5) Tocris Compounds for MYH13 Gene

Compound Action Cas Number
(+-)-Blebbistatin Selective inhibitor of myosin II ATPase activity 674289-55-5
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 1177356-70-5
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760) 856925-71-8
ML 9 hydrochloride Myosin light chain kinase inhibitor 105637-50-1
W-7 hydrochloride Calmodulin antagonist. Inhibits myosin light chain kinase 61714-27-0
genes like me logo Genes that share compounds with MYH13: view

Transcripts for MYH13 Gene

mRNA/cDNA for MYH13 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYH13 Gene

Myosin, heavy chain 13, skeletal muscle:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYH13 Gene

No ASD Table

Relevant External Links for MYH13 Gene

GeneLoc Exon Structure for
MYH13
ECgene alternative splicing isoforms for
MYH13

Expression for MYH13 Gene

mRNA expression in normal human tissues for MYH13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYH13 Gene

This gene is overexpressed in Muscle - Skeletal (x32.6) and Stomach (x8.3).

Protein differential expression in normal tissues from HIPED for MYH13 Gene

This gene is overexpressed in Heart (51.6) and Esophagus (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYH13 Gene



SOURCE GeneReport for Unigene cluster for MYH13 Gene Hs.711142

mRNA Expression by UniProt/SwissProt for MYH13 Gene

Q9UKX3-MYH13_HUMAN
Tissue specificity: Specifically expressed in extraocular and laryngeal muscles.
genes like me logo Genes that share expression patterns with MYH13: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for MYH13 Gene

Orthologs for MYH13 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYH13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYH13 35
  • 90.33 (n)
  • 94.36 (a)
MYH13 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYH13 35
  • 89.92 (n)
  • 94.79 (a)
MYH13 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myh13 35
  • 89.35 (n)
  • 96.08 (a)
Myh13 16
Myh13 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYH13 35
  • 99.31 (n)
  • 99.59 (a)
MYH13 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myh13 35
  • 87.29 (n)
  • 92.02 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
-- 36
  • 83 (a)
ManyToMany
chicken
(Gallus gallus)
Aves MYH13 35
  • 78.65 (n)
  • 84.73 (a)
MYH13 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYH13 36
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mhc 37
  • 48 (a)
Prm 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea F45G2.2 37
  • 44 (a)
F58G4.1 37
  • 46 (a)
hcp-1 37
  • 21 (a)
hcp-2 37
  • 21 (a)
myo-3 37
  • 46 (a)
Y11D7A.14 37
  • 29 (a)
Species with no ortholog for MYH13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MYH13 Gene

ENSEMBL:
Gene Tree for MYH13 (if available)
TreeFam:
Gene Tree for MYH13 (if available)

Paralogs for MYH13 Gene

Paralogs for MYH13 Gene

Pseudogenes.org Pseudogenes for MYH13 Gene

genes like me logo Genes that share paralogs with MYH13: view

Variants for MYH13 Gene

Sequence variations from dbSNP and Humsavar for MYH13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2074877 - 10,320,397(+) ATCCA(C/T)AATGG reference, missense
rs2190729 - 10,333,147(+) GACCC(C/T)GTTAC reference, missense
rs2074876 - 10,320,380(+) TGCTT(G/T)TCATT reference, missense
rs17690195 - 10,315,796(+) CCACT(C/G/T)GGTGG reference, missense
rs3744550 - 10,303,278(+) TCTTG(C/T)GGTCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MYH13 Gene

Variant ID Type Subtype PubMed ID
nsv907673 CNV Gain 21882294
nsv520771 CNV Gain+Loss 19592680
nsv907679 CNV Gain 21882294
nsv457667 CNV Loss 19166990
esv2648260 CNV Deletion 19546169
esv2673102 CNV Deletion 23128226
nsv827883 CNV Loss 20364138
esv22034 CNV Gain 19812545
nsv833366 CNV Gain 17160897

Variation tolerance for MYH13 Gene

Residual Variation Intolerance Score: 98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.40; 97.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYH13 Gene

HapMap Linkage Disequilibrium report
MYH13
Human Gene Mutation Database (HGMD)
MYH13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYH13 Gene

Disorders for MYH13 Gene

Relevant External Links for MYH13

Genetic Association Database (GAD)
MYH13
Human Genome Epidemiology (HuGE) Navigator
MYH13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYH13

No disorders were found for MYH13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYH13 Gene

Publications for MYH13 Gene

  1. The human extraocular muscle myosin heavy chain gene (MYH13) maps to the cluster of fast and developmental myosin genes on chromosome 17. (PMID: 9806854) Winters L.M. … Schachat F. (Genomics 1998) 2 3 4 23 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Slow skeletal muscle myosin-binding protein-C (MyBPC1) mediates recruitment of muscle-type creatine kinase (CK) to myosin. (PMID: 21426302) Chen Z. … Zhou H.M. (Biochem. J. 2011) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. (PMID: 20618440) Pozuelo-Rubio M. (FEBS J. 2010) 3

Products for MYH13 Gene

Sources for MYH13 Gene

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