MYH11 Gene
protein-coding GIFtS : 70 GCID: GC16 M015704
myosin, heavy chain 11, smooth muscle myosin, heavy polypeptide 11, smooth muscle )
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Aliasesfor MYH11 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Myosin, Heavy Chain 11, Smooth Muscle 1 2 Myosin Heavy Chain, Smooth Muscle Isoform2 3 SMMHC1 2 3 AAT42 5 SMHC1 2 FAA42 5 Myosin, Heavy Polypeptide 11, Smooth Muscle1 2 Myosin-111 Myosin Heavy Chain 112 3 KIAA08663
Export aliases for MYH11 gene to outside databases Previous GC identifers: GC16M015624 GC16M015079 GC16M015724 GC16M015763 GC16M015190
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Summariesfor MYH11 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MYH11 : The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 (inv(16)(p13q22)) produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: MYH11_HUMAN, P35749 Function : Muscle contractionsummary
for MYH11 : Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin bindingand potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domainthat binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interactswith cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatorymyosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It isinvolved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating acontractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and byintracellular Ca2+ concentrations. Gene Wiki entry for MYH11
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Genomic Viewsfor MYH11 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000016.9 NC_018927.1 NT_010393.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MYH11 gene promoter:GR FOXI1 HFH-3 Ik-2 GR-beta GR-alpha C/EBPalpha Other transcription factors Search SABiosciences Chromatin IP Primers for MYH11 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 16p13.11 Ensembl cytogenetic band: 16p13.11 HGNC cytogenetic band: 16p13.11 MYH11 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16M015704: view genomic region
(about GC identifiers )
Start: 15,796,992 bp from pter End:
15,950,890 bp from pter
Size: 153,899 bases Orientation:
minus strand
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Proteinsfor MYH11 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MYH11_HUMAN, P35749 See
protein sequence )Recommended Name: Size : 1972 amino acids; 227339 DaSubunit : Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chainsubunits (MLC) and 2 regulatory light chain subunits (MLC-2)
Subcellular location : Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stageIV. Thick filaments of the myofibrils
Sequence caution : Sequence=BAA74889.2; Type=Erroneous initiation;Secondary accessions : O00396 O94944 P78422 Q3MIV8 Q3MNF0 Q3MNF1Alternative splicing : 4 isoforms : P35749-1 P35749-2 P35749-3 P35749-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MYH11: NX_P35749 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P35749 MYH11 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (4 alternative transcripts): NP_001035202.1 NP_001035203.1 NP_002465.1 NP_074035.1 ENSEMBL proteins: ENSP00000379616 ENSP00000407821 ENSP00000458731 ENSP00000300036 ENSP00000345136 Reactome Protein details: P35749 Human Recombinant Protein Products: Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing MYH11 Antibody Products: Assay Products for MYH11:
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Protein
Domains /for MYH11 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P35749 ProtoNet protein and cluster: P35749
3 Blocks protein families : IPB000048 IPB002928 IPB004009 UniProtKB/Swiss-Prot: MYH11_HUMAN, P35749 Domain : The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4heptapeptides, characteristic for alpha-helical coiled coils Domain : Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can laterbe split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2) Similarity : Contains 1 IQ domainSimilarity : Contains 1 myosin head-like domain
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Functionfor MYH11 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: MYH11_HUMAN, P35749 Function : Muscle contraction
Genatlas biochemistry entry for MYH11 myosin,motor contractile protein moving towards the "plus" end of actin track,heavy polypeptide 11,smooth muscle,altered in acute myeloid leukemia (AML-M4Eo) with inversion inv(16)(p13-q22),forming chimeric protein with CBFB Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 6 )human mouse rat see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 4 ): MYH11 (NM_022844 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYH11 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MYH11
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH11
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing Animal Models: Myh11 tm1Bdr Myh11 tm2Peri Myh11 tm1Peri 9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Myh11) :About GeneDecksing
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Pathways & Interactionsfor MYH11 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/17 super-pathways (see all 17 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Cell adhesion_Integrin-mediated cell adhesion and migration 2 Immune response _CCR3 signaling in eosinophils 3 PAK Pathway 4 Sema4D in semaphorin signaling 5 Axon guidance
Pathway sources See GeneCards unified pathways Show all pathways 5 5/11 (see all 11 )5/6 (see all 6 )5/7 (see all 7 )3 (Kegg details for MYH11) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MYH11 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/127 Interacting proteins for MYH11 (P35749 1 , 2 , 3 ENSP00000379616 4 via UniProtKB, MINT, STRING , and/or I2D (see all 127 )About this table Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing
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Drugs & Compoundsfor MYH11 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Compounds for MYH11 available from Tocris Bioscience About this table Compound Action
CAS
# (R)-(+)-Blebbistatin Selective inhibitor of myosin II. Inactive enantiomer of (±)-blebbistatin (Cat. No. 1760) -- (S)-(-)-Blebbistatin Selective inhibitor of myosin II. Active enantiomer of (±)-blebbistatin (Cat. No. 1760) [856925-71-8] (±)-Blebbistatin Selective inhibitor of myosin II [674289-55-5]
2 DrugBank Compounds for MYH11 About this table 10/12 Novoseek chemical compound relationships for MYH11 gene (see all 12 ) About this table MYH11
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Transcriptsfor MYH11 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MYH11 gene (4 alternative transcripts): NM_001040113.1 NM_001040114.1 NM_002474.2 NM_022844.2 Unigene Cluster for MYH11:
Myosin, heavy chain 11, smooth muscle Hs.460109 [show with all ESTs ] Unigene Representative Sequence: NM_001040113 12 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000396324 ENST00000452625 ENST00000573908 ENST00000576790 ENST00000300036 ENST00000576164 ENST00000571275 (uc010bvh.3 ) ENST00000574119 ENST00000570785 (uc002dea.1 )ENST00000571910 ENST00000571505 (uc002deb.3 ) ENST00000338282 (uc002ddv.3 uc002ddw.3 uc002ddx.3 uc002ddy.3 uc010bvg.3 )Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 6 )human mouse rat see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 4 ): MYH11 (NM_022844 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYH11 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MYH11
Additional cDNA sequence: AB020673.2 AF013570.1 AF020091.1 AK097036.1 AK125033.1 AK130413.1 AK308389.1 AK311080.1 AY520816.1 AY520817.1 BC031040.1 BC080545.1 BC101677.1 BC104906.1 BC143364.1 BX641087.1 CR749516.1 D10667.1 EU489063.1 S67238.1 S67240.1 X69292.1
24/60 DOTS entries (see all 60 ): DT.92462085 DT.319908
DT.95194449 DT.92338250 DT.100886298 DT.95097778 DT.92462100 DT.95360288 DT.100886307 DT.92367239 DT.91955791 DT.87078354 DT.120692421 DT.100886312 DT.92462086 DT.40263399 DT.105335 DT.120692268 DT.100656720 DT.319913 DT.95077661 DT.95263528 DT.100886309 DT.102841981 24/46 AceView cDNA sequences (see all 46 ):
T64384 CB051599 AA403323 AA490636 AA456649 AA400026 AA398387 CD614958 T64197 BE836037 H67531 BF858934 BE769923 H45725 H67530 BF370633 AI335421 AW844110 BF846288 AW603577 T64139 BE836005 BQ066154 AI810812 GeneLoc Exon Structure 5/16 Alternative Splicing Database (ASD) splice patterns (SP) for MYH11 (see all 16 ) About this scheme ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b ^ 20a · SP1 : - SP2 : - SP3 : SP4 : - SP5 :
ExUns: 20b ^ 21a · 21b ^ 22a · 22b · 22c ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28a · 28b · 28c ^ 29 SP1 : SP2 : SP3 : - SP4 : SP5 : -
ECgene alternative splicing isoforms for MYH11
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Expression for MYH11 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MYH11 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AATTGAAAAG
About this image MYH11 expression in embryonic tissues and stem cells About this table See MYH11 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MYH11 SOURCE GeneReport for Unigene cluster: Hs.460109 UniProtKB/Swiss-Prot: MYH11_HUMAN, P35749 Tissue specificity : Smooth muscle; expressed in the umbilical artery, bladder, esophagus and trachea. Isoform 1 ismostly found in slowly contracting tonic muscles SABiosciences Expression via Pathway-Focused PCR Arrays including MYH11 : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH11
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Orthologsfor MYH11 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for MYH11 gene from 6/24 species (see all 24 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves MYH111
myosin, heavy chain 11, smooth muscle
78.18(n) 89.78(a)
396211 NM_205274.1 NP_990605.1
lizard Reptilia MYH116
--
85(a)
1 ↔ 1
GL344644.1(40910-51965)
zebrafish Actinopterygii myh11a1
myosin, heavy polypeptide 11, smooth muscle a
74.54(n) 80.9(a)
554168 NM_001024448.1 NP_001019619.1
fruit fly Insecta zip3
NOT muscle attachment myosin ATPase
60(a)
--
worm Secernentea nmy-13
myosin
50(a)
X(2944856-2952845) --
baker's yeast Saccharomycetes MYO11
Myo1p
43(n) 33.3(a)
856418 NP_011888.1
ENSEMBL Gene Tree for MYH11 (if available)TreeFam Gene Tree for MYH11 (if available)
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Paralogsfor MYH11 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MYH11 gene MYH8 2 MYH1 2 MYH2 2 MYH14 2 MYH9 2 MYH13 2 MYH10 2 MYH7B 2 MYH4 2 MYH3 2 MYH15 2 MYH6 2 MYH7 2 18/39 SIMAP similar genes for MYH11 using alignment to 5 protein entries: MYH11_HUMAN (see all proteins )
(see all similar genes ):DKFZp686D10126 MYH9 MYH10 FLJ00279 MYH14 MYH2 MYO15A MYO3B MYO1G MYO9A MYO1C MYO18A MYH8 MYO5C MYH13 MYH1 MYH4 MYO5A About GeneDecksing
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Genomic Variantsfor MYH11 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 16 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for MYH11 (15796992 - 15950890 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 8 variations for MYH11 8 CNVs 72484 4926 49658 30745 72483 29660 49657 2203 Human Gene Mutation Database (HGMD) : MYH11 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor MYH11 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 160745 OMIM disorders : 132900 UniProtKB/Swiss-Prot: MYH11_HUMAN, P35749 Note=A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11 Defects in MYH11 are the cause of familial aortic aneurysm thoracic type 4 (AAT4) [MIM:132900]; also known as familial thoracic aortic aneurysm and dissection (TAAD). Aneurysms and dissections of the aorta usually result from degenerative changes in the aortic wall. Thoracic aortic aneurysms and dissections are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. Patients with AAT4 show marked aortic stiffness. Pathological aortas show large areas of medial degeneration with very low smooth muscle cells content 20/58 (see all 58 ): About MalaCards acute myeloid leukemia aortic aneurysm, familial thoracic 4 myeloid leukemia polymorphous low-grade adenocarcinoma thoracic aortic aneurysm thoracic aortic aneurysms and aortic dissections aortic aneurysm familial thoracic aortic aneurysm and dissection malignant peripheral nerve sheath tumor extraskeletal myxoid chondrosarcoma leukemia creatine phosphokinase dna topoisomerase ii patent ductus arteriosus gastrointestinal stromal tumor myxoid chondrosarcoma intraductal papilloma waldenstrom macroglobulinemia ectopic pregnancy lymphoplasmacytic lymphoma 3 diseases from the University of Copenhagen DISEASES database for MYH11 :Acute myeloid leukemia Eosinophilia Acute leukemia 10/24 Novoseek disease relationships for MYH11 gene (see all 24 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma ductal
54.5
1
15762278 (1)
aortic dissection
51.6
11
8653847 (3), 9324878 (2), 11015167 (2), 18413993 (2) (see all 6 )
dissection aortic acute
51.5
3
11015167 (2), 19124441 (1)
aortic aneurysm thoracic
51
1
17956658 (1)
papilloma intraductal
49.1
2
16861972 (1), 15762278 (1)
eosinophilia
46.6
4
17452259 (1), 9713991 (1), 8779782 (1)
carcinoma adenoid cystic
43.3
15
18084258 (3), 16810311 (2)
adenoma pleomorphic
30.2
3
9388059 (1), 10458827 (1)
leukemia
26.4
1
15754009 (1)
carcinoma
22.9
4
9702855 (1), 12502930 (1), 10204102 (1), 18936688 (1)
GeneTests: MYH11 Thoracic Aortic Aneurysms and Aortic Dissections Genetic Association Database (GAD): MYH11 Human Genome Epidemiology (HuGE) Navigator: MYH11 (3 documents) Export disorders for MYH11 gene to outside databases
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Publicationsfor MYH11 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MYH11 gene, integrated from 9 sources (see all 220 ):(articles sorted by number of sources associating them with MYH11) Utopia : connect your pdf to the dynamic
Human smooth muscle myosin heavy chain gene mapped to chromosomal region 16q12. (PubMed id 7684189) 1 , 2 , 3, 9(1993) Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus. (PubMed id 16444274) 1 , 2 , 9(2006) Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065) 1 , 2 (2006) [Role of molecular screening for common fusion genes in the diagnosis and classification of leukemia] (PubMed id 15968309) 1 , 4(2005) (+)Insert smooth muscle myosin heavy chain (SM-B) isoform expression in human tissues. (PubMed id 16000639) 1 , 2 (2005) Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829) 1 , 2 (1999) Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485) 1 , 2 (1998) Somatic mutation analysis of MYH11 in breast and prostate cancer. (PubMed id 18796164) 1 , 9(2008) Myosin heavy chain gene expression in normal and hyperplastic human prostate tissue. (PubMed id 10906735) 1 , 9(2000) Investigation of the MYH11 gene in sporadic patients with an isolated persistently patent arterial duct. (PubMed id 17956658) 1 , 9(2007)
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External Searches for MYH11 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MYH11 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing MYH11 gene
(According to HUGE )
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Specialized Databases showing MYH11 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for MYH11 gene: MYH11 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MYH11 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for MYH11 OriGene shRNA RFP for MYH11 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for MYH11 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MYH11 OriGene 3'-UTR Clone for MYH11 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MYH11 OriGene Custom Protein Services for MYH11 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MYH11 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Tocris compounds for MYH11
MYH11 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH11
ThermoFisher Antibodies for MYH11
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MYH11
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summary
for 
Kegg Pathways 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Microarrays
In-situ hybridization
