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Aliases for MYH10 Gene

Aliases for MYH10 Gene

  • Myosin, Heavy Chain 10, Non-Muscle 2 3 5
  • Myosin, Heavy Polypeptide 10, Non-Muscle 2 3
  • Cellular Myosin Heavy Chain, Type B 3 4
  • NMMHC-IIB 3 4
  • Myosin Heavy Chain, Nonmuscle Type B 3
  • Myosin Heavy Chain, Non-Muscle IIb 4
  • Nonmuscle Myosin II Heavy Chain-B 3
  • Non-Muscle Myosin Heavy Chain IIb 4
  • Nonmuscle Myosin Heavy Chain IIB 3
  • Non-Muscle Myosin Heavy Chain B 4
  • Myosin Heavy Chain 10 4
  • NMMHC II-B 4
  • NMMHC-B 4
  • NMMHCB 3

External Ids for MYH10 Gene

Previous GeneCards Identifiers for MYH10 Gene

  • GC17M008754
  • GC17M009471
  • GC17M008320
  • GC17M008579
  • GC17M008580
  • GC17M008318

Summaries for MYH10 Gene

Entrez Gene Summary for MYH10 Gene

  • This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for MYH10 Gene

MYH10 (Myosin, Heavy Chain 10, Non-Muscle) is a Protein Coding gene. Diseases associated with MYH10 include may-hegglin anomaly and lymphangioleiomyomatosis. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is MYH4.

UniProtKB/Swiss-Prot for MYH10 Gene

  • Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9.

Tocris Summary for MYH10 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.

Gene Wiki entry for MYH10 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYH10 Gene

Genomics for MYH10 Gene

Regulatory Elements for MYH10 Gene

Promoters for MYH10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MYH10 on UCSC Golden Path with GeneCards custom track

Genomic Location for MYH10 Gene

Chromosome:
17
Start:
8,474,205 bp from pter
End:
8,631,012 bp from pter
Size:
156,808 bases
Orientation:
Minus strand

Genomic View for MYH10 Gene

Genes around MYH10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYH10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYH10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYH10 Gene

Proteins for MYH10 Gene

  • Protein details for MYH10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35580-MYH10_HUMAN
    Recommended name:
    Myosin-10
    Protein Accession:
    P35580
    Secondary Accessions:
    • B2RWP9
    • D3DTS1
    • F8VTL3
    • Q12989
    • Q149N3
    • Q149N4
    • Q16087
    • Q4LE45
    • Q6PK16
    • Q9BWG0

    Protein attributes for MYH10 Gene

    Size:
    1976 amino acids
    Molecular mass:
    228999 Da
    Quaternary structure:
    • Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with PLEKHG6. Interacts with ECM29. Interacts with KIF26B (By similarity). Interacts with LARP6. Interacts with MCC.
    SequenceCaution:
    • Sequence=BAE06108.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MYH10 Gene

    Alternative splice isoforms for MYH10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYH10 Gene

Proteomics data for MYH10 Gene at MOPED

Post-translational modifications for MYH10 Gene

Other Protein References for MYH10 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MYH10 (MYH10)

No data available for DME Specific Peptides for MYH10 Gene

Domains & Families for MYH10 Gene

Gene Families for MYH10 Gene

Graphical View of Domain Structure for InterPro Entry

P35580

UniProtKB/Swiss-Prot:

MYH10_HUMAN :
  • The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
  • Contains 1 IQ domain.
  • Contains 1 myosin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYH10: view

Function for MYH10 Gene

Molecular function for MYH10 Gene

GENATLAS Biochemistry:
myosin,motor contractile protein moving towards the "plus" end of actin track,heavy polypeptide 10,non muscle
UniProtKB/Swiss-Prot Function:
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9.

Gene Ontology (GO) - Molecular Function for MYH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 contributes_to actin filament binding IEA,IMP 24072716
genes like me logo Genes that share ontologies with MYH10: view
genes like me logo Genes that share phenotypes with MYH10: view

Animal Models for MYH10 Gene

MGI Knock Outs for MYH10:

Animal Model Products

  • Taconic Biosciences Mouse Models for MYH10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYH10 Gene

Localization for MYH10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYH10 Gene

Cell projection, lamellipodium. Note=Colocalizes with MCC at the leading edge of migrating cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYH10 Gene COMPARTMENTS Subcellular localization image for MYH10 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
mitochondrion 5
nucleus 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MYH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005819 spindle IEA --
GO:0005938 cell cortex IDA 7699007
GO:0015629 actin cytoskeleton IDA --
GO:0016459 myosin complex IEA,NAS 7499478
GO:0043197 dendritic spine IEA --
genes like me logo Genes that share ontologies with MYH10: view

Pathways & Interactions for MYH10 Gene

genes like me logo Genes that share pathways with MYH10: view

SIGNOR curated interactions for MYH10 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MYH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IDA 15774463
GO:0003279 cardiac septum development IEA --
GO:0006887 exocytosis IEA --
GO:0007411 axon guidance IEA,TAS --
GO:0007512 adult heart development IEA --
genes like me logo Genes that share ontologies with MYH10: view

Drugs & Compounds for MYH10 Gene

(2) Drugs for MYH10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for MYH10 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-Blebbistatin
674289-55-5
(R)-(+)-Blebbistatin
1177356-70-5
(S)-(-)-Blebbistatin
856925-71-8
ML 9 hydrochloride
105637-50-1
W-7 hydrochloride
61714-27-0

(5) Tocris Compounds for MYH10 Gene

Compound Action Cas Number
(+-)-Blebbistatin Selective inhibitor of myosin II ATPase activity 674289-55-5
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 1177356-70-5
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760) 856925-71-8
ML 9 hydrochloride Myosin light chain kinase inhibitor 105637-50-1
W-7 hydrochloride Calmodulin antagonist. Inhibits myosin light chain kinase 61714-27-0
genes like me logo Genes that share compounds with MYH10: view

Transcripts for MYH10 Gene

Unigene Clusters for MYH10 Gene

Myosin, heavy chain 10, non-muscle:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYH10 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1:
SP2:
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: - -
SP11:
SP12:
SP13:

ExUns: 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26 ^ 27
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MYH10 Gene

GeneLoc Exon Structure for
MYH10
ECgene alternative splicing isoforms for
MYH10

Expression for MYH10 Gene

mRNA expression in normal human tissues for MYH10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYH10 Gene

This gene is overexpressed in Artery - Aorta (x15.0), Artery - Coronary (x6.6), and Artery - Tibial (x4.0).

Protein differential expression in normal tissues from HIPED for MYH10 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYH10 Gene



SOURCE GeneReport for Unigene cluster for MYH10 Gene Hs.16355

mRNA Expression by UniProt/SwissProt for MYH10 Gene

P35580-MYH10_HUMAN
Tissue specificity: Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum.
genes like me logo Genes that share expression patterns with MYH10: view

Protein tissue co-expression partners for MYH10 Gene

Primer Products

In Situ Assay Products

Orthologs for MYH10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYH10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYH10 35
  • 90.77 (n)
  • 98.58 (a)
MYH10 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYH10 35
  • 90.35 (n)
  • 98.95 (a)
MYH10 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myh10 35
  • 89.57 (n)
  • 99.09 (a)
Myh10 16
Myh10 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYH10 35
  • 99.58 (n)
  • 100 (a)
MYH10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myh10 35
  • 89.29 (n)
  • 98.79 (a)
oppossum
(Monodelphis domestica)
Mammalia MYH10 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYH10 35
  • 83.09 (n)
  • 95.71 (a)
MYH10 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYH10 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20258 35
LOC100493774 35
  • 71.03 (n)
  • 76.64 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.833 35
zebrafish
(Danio rerio)
Actinopterygii myh10 35
  • 78.6 (n)
  • 90.06 (a)
myh10 36
  • 90 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3493 37
  • 22 (a)
zip 37
  • 61 (a)
zip 35
  • 61.45 (n)
  • 63.27 (a)
zip 36
  • 60 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007523 35
  • 62.64 (n)
  • 64.11 (a)
worm
(Caenorhabditis elegans)
Secernentea hcp-1 37
  • 20 (a)
hcp-2 37
  • 19 (a)
nmy-1 35
  • 57.21 (n)
  • 52.71 (a)
nmy-1 36
  • 52 (a)
ManyToMany
nmy-2 36
  • 44 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO1 36
  • 30 (a)
OneToMany
MYO1 38
Species with no ortholog for MYH10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYH10 Gene

ENSEMBL:
Gene Tree for MYH10 (if available)
TreeFam:
Gene Tree for MYH10 (if available)

Paralogs for MYH10 Gene

Paralogs for MYH10 Gene

genes like me logo Genes that share paralogs with MYH10: view

Variants for MYH10 Gene

Sequence variations from dbSNP and Humsavar for MYH10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs166563 -- 8,498,643(+) GAGAT(C/G/T)GAGAC intron-variant
rs10520 -- 8,474,948(-) CTCCC(A/C/T)ATCGC utr-variant-3-prime
rs174853 -- 8,581,767(+) CATTA(C/T)TGTCC intron-variant
rs174900 -- 8,498,585(+) gctca(G/T)gcctg intron-variant
rs174901 -- 8,498,675(+) acccc(A/G)tctct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYH10 Gene

Variant ID Type Subtype PubMed ID
esv2715614 CNV Deletion 23290073
esv2112361 CNV Deletion 18987734
nsv111760 CNV Loss 16902084
esv1105639 CNV Deletion 17803354
esv2715615 CNV Deletion 23290073
nsv111869 CNV Loss 16902084
esv2715616 CNV Deletion 23290073
nsv907664 CNV Loss 21882294
nsv510433 CNV Loss 20534489
esv270828 CNV Insertion 20981092
nsv907665 CNV Loss 21882294
nsv510434 CNV Loss 20534489

Variation tolerance for MYH10 Gene

Residual Variation Intolerance Score: 0.373% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYH10 Gene

HapMap Linkage Disequilibrium report
MYH10
Human Gene Mutation Database (HGMD)
MYH10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYH10 Gene

Disorders for MYH10 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MYH10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
may-hegglin anomaly
  • dohle leukocyte inclusions with giant platelets
lymphangioleiomyomatosis
  • lymphangioleiomyomatosis, somatic
gitelman syndrome
  • hypomagnesemia-hypokalemia, primary renotubular, with hypocalciuria
- elite association - COSMIC cancer census association via MalaCards
Search MYH10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYH10

Genetic Association Database (GAD)
MYH10
Human Genome Epidemiology (HuGE) Navigator
MYH10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYH10
genes like me logo Genes that share disorders with MYH10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYH10 Gene

Publications for MYH10 Gene

  1. Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes. (PMID: 1860190) Simons M. … Weir L. (Circ. Res. 1991) 2 3 4 67
  2. Estrogen modulation of MgATPase activity of nonmuscle myosin-II-B filaments. (PMID: 17023528) Gorodeski G.I. (Endocrinology 2007) 3 23
  3. Protein kinase Cgamma regulates myosin IIB phosphorylation, cellular localization, and filament assembly. (PMID: 16394101) Rosenberg M. … Ravid S. (Mol. Biol. Cell 2006) 3 23
  4. Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C. (PMID: 15845534) Kim K.Y. … Adelstein R.S. (J. Biol. Chem. 2005) 3 23
  5. The resident endoplasmic reticulum protein, BAP31, associates with gamma-actin and myosin B heavy chain. (PMID: 12605685) Ducret A. … Shore G.C. (Eur. J. Biochem. 2003) 3 23

Products for MYH10 Gene

Sources for MYH10 Gene

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