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MYH10 Gene

protein-coding GIFtS: 65

GC17M008318

myosin, heavy chain 10, non-muscle
(Previous names: myosin, heavy polypeptide 10, non-muscle )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MGC134913 ^²
MGC134914 ^²
NMMHC-B ^³
NMMHC-IIB ^³
NMMHCB ^¹, ²

Descriptions
Cellular myosin heavy chain, type B ^³
Myosin heavy chain 10 ^³
Myosin heavy chain, non-muscle IIb ^³
NMMHC II-b ^³
Non-muscle myosin heavy chain B ^³
Non-muscle myosin heavy chain IIb ^³
cellular myosin heavy chain, type B type B ^²
myosin heavy chain, nonmuscle type B ^²
myosin, heavy chain 10, non-muscle ^²
myosin, heavy polypeptide 10, non-muscle ^¹, ²
near to the ATP binding region ^²
nonmuscle myosin II heavy chain-B ^²
nonmuscle myosin heavy chain IIB ^²
nonmuscle myosin heavy chain-B ^²

External Ids
HGNC: 7568¹
Entrez Gene: 4628²
UniProtKB: P35580³
Ensembl: ENSG00000133026⁷

Search outside databases for aliases for MYH10 gene

Previous GC identifers: GC17M008754 GC17M009471 GC17M008320 GC17M008579 GC17M008580

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: MYH10_HUMAN, P35580

Function: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized

functions such as secretion and capping

Gene Wiki entry for MYH10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MYH10 gene

Entrez Gene cytogenetic band: 17p13 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13

MYH10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M008318: (about GC identifiers)

Start:	8,318,248 bp from pter
End:	8,474,804 bp from pter
Size:	156,557 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MYH10_HUMAN, P35580 (See protein sequence)

Recommended Name: Myosin-10

Size: 1976 amino acids; 228999 Da

Subunit: Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali

light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with PLEKHG6

Secondary accessions: Q12989 Q149N3 Q16087

Alternative splicing: 3 isoforms: P35580-1 P35580-2 P35580-3

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005955.1

ENSEMBL proteins:

ENSP00000369315 ENSP00000353590 ENSP00000379539 ENSP00000269243

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (non-muscle heavy chain Myosin)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/13 Gene Ontology (GO) cellular component terms (links to tree view) (see all 13 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001725	stress fiber	IDA	7699007
GO:0005737	cytoplasm	IDA	7699007
GO:0005819	spindle	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005938	cell cortex	IDA	7699007

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Antibodies for MYH10:

	Invitrogen Antibodies for MYH10
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for MYH10
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for MYH10 (Myosin 2b)
	Antibodies from Abcam (non-muscle heavy chain Myosin), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for MYH10

Assays for MYH10:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P35580

ProtoNet protein and cluster: P35580

4 Blocks protein families:

IPB000048 IQ calmodulin-binding region

IPB002017 Spectrin repeat

IPB002928 Myosin tail

IPB004009 Myosin N-terminal SH3-like domain

UniProtKB/Swiss-Prot: MYH10_HUMAN, P35580

Domain: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat

pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils

Similarity: Contains 1 IQ domain

Similarity: Contains 1 myosin head-like domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MYH10)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005964

Applied Biosystems Silencer® siRNAs for MYH10

Sigma-Aldrich siRNA for MYH10

Sigma-Aldrich shRNA Panels and shRNA for MYH10

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005964
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005964
untagged cDNA clone in CMV expression vector: NM_005964

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005964

UniProtKB/Swiss-Prot: MYH10_HUMAN, P35580

Function: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized

functions such as secretion and capping

Genatlas biochemistry entry for MYH10:

myosin,motor contractile protein moving towards the "plus" end of actin track,heavy polypeptide

10,non muscle

12 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Myh10):

	behavior/neurological	craniofacial	growth/size	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system	muscle	nervous system
skeleton	vision/eye

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000146	microfilament motor activity	IDA	15845534
GO:0000166	nucleotide binding	IEA	--
GO:0005516	calmodulin binding	IEA	--
GO:0005524	ATP binding	NAS	7782316
GO:0030898	actin-dependent ATPase activity	IDA	15845534

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for MYH10 (Your Favorite Gene powered by Ingenuity)

Calcium Signaling
Cellular Effects of Sildenafil (Viagra)
Tight Junction Signaling
Hepatic Fibrosis / Hepatic Stellate Cell Activation
Actin Cytoskeleton Signaling

GeneDecks MYH10 for the pathways selected above

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5/31 Interacting proteins for MYH10 (ENSP00000269243³ P35580^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 31 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IKBKE	Q14164¹^,²	EBI-351758, EBI-307369 MINT-48102 EBI-351758, EBI-307369 MINT-48102
LLGL1	Q15334¹	EBI-351758, EBI-299979
MCC	P23508¹	EBI-351758, EBI-307531
PAK2	Q13177¹	EBI-351758, EBI-1045887
PRKAB1	Q9Y478¹	EBI-351758, EBI-719769

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5/24 Gene Ontology (GO) biological process terms (links to tree view) (see all 24 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000281	cytokinesis after mitosis	IDA	15774463
GO:0001701	in utero embryonic development	IEA	--
GO:0001764	neuron migration	IEA	--
GO:0001778	plasma membrane repair	IEA	--
GO:0006887	exocytosis	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for MYH10 available from Tocris Bioscience

Compound	Action	CAS number
(�)-Blebbistatin	Selective inhibitor of myosin II	[674289-55-5]

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2 Novoseek chemical compound relationships for MYH10 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
actomyosin	69.34	3	16901965 (1), 12605685 (1), 17023528 (1)
atp	0.81	1	8663598 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MYH10)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005964

Sigma-Aldrich siRNA for MYH10

Sigma-Aldrich shRNA Panels and shRNA for MYH10

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005964

REFSEQ mRNAs for MYH10 gene:

NM_005964.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005964

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005964
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005964
                                 untagged cDNA clone in CMV expression vector: NM_005964

Additional cDNA sequence:

AB210026.1 AF086505.1 AK026977.1 BC000280.1 BC008968.2 BC117690.1 BC117691.1 BC144668.1

BC150634.1 CR602815.1 DQ925667.1 M69181.1 S67247.1 U15618.1 U34304.1

20 DOTS entries:

DT.219373 DT.100821046 DT.91719949 DT.91817109 DT.102837546 DT.435880 DT.219370 DT.120920828

DT.40211646 DT.92434433 DT.99994616 DT.100821044 DT.92434421 DT.95235074 DT.95309574 DT.95343009

DT.97818271 DT.100821042 DT.75158458 DT.91955343

24/395 AceView cDNA sequences (see all 395 ):

AW473979 F12205 BU735889 AI825348 AA340297 NM_005964 BQ227385 CF541342

AW877049 AI277790 AA490477 BE699108 N75446 F04914 BQ189148 AI129361

BE781189 CB243057 BX105953 BQ688008 AA029574 BF507359 BM981822 BU182128

highest scoring ESTs for MYH10:

AA355800 AI382123 AL119272 BE734186 BG479223 BG723653 BU173337 S67247 U34304 M69181

Unigene Cluster for MYH10:

Myosin, heavy chain 10, non-muscle

Hs.16355 [show with all ESTs]

Unigene Representative Sequence: AB210026

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MYH10 (see all 13 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14a	·	14b	·	14c	^	15a	·	15b	^	16	^	17	^	18	^	19	^
SP1:
SP2:
SP3:																																							-
SP4:																																							-
SP5:

ExUns:	20	^	21a	·	21b	·	21c	^	22a	·	22b	^	23a	·	23b	^	24	^	25a	·	25b	^	26	^	27
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for MYH10

4 Ensembl transcripts including schematic representations:

ENST00000379980 ENST00000360416 ENST00000396239 ENST00000269243

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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MYH10 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MYH10

¹ / ² / ³

8 probe-sets matching MYH10 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32838_at²^{, 3}	U95-A	1	1.00	1.00	0.92	1.15	S67247	0.80	1.00	0.91	1
40900_at²^{, 3}	U95-A	1	1.00	1.00	0.61	0.28	AI382123	0.80	1.00	0.91	1
68979_g_at²^{, 3}	U95-E	1	1.00	1.00	0.96	0.73	AA501869	0.60	1.00	0.82	1
68976_at²^{, 3}	U95-E	1	0.69	1.00	0.69	1.14	AA501869	0.60	1.00	0.82	1
213067_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI382123	0.80	1.00	0.91	1
212372_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK026977	0.60	1.00	0.82	1
213067_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212372_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks MYH10 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TACCTCTCTA

SOURCE GeneReport for Unigene cluster: Hs.16355
Expression variation in blood from EXPOLDB for MYH10
UniProtKB/Swiss-Prot: MYH10_HUMAN, P35580
Tissue specificity: In brain, isoform 1 is predominantly expresssed in cerebellum and spinal chord,
isoform 2 in cerebrum and retina; isoform 3 is expressed in the cerebebrum and to a much lower
extent in cerebellum

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MYH10 gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MYH10¹	--	myosin, heavy chain 10, non-muscle	90.22(n) 98.94(a)	479497 XM_845005.1 XP_850098.1
chimpanzee (Pan troglodytes)	MYH10¹	--	myosin, heavy chain 10, non-muscle	99.58(n) 100(a)	455090 XM_511852.2 XP_511852.2
cow (Bos taurus)	MYH10¹	--	myosin, heavy chain 10, non-muscle	90.77(n) 98.58(a)	317655 NM_174834.1 NP_777259.1
rat (Rattus norvegicus)	Myh10¹	--	myosin, heavy chain 10, non-muscle	89.29(n) 98.79(a)	79433 NM_031520.1 NP_113708.1
mouse (Mus musculus)	Myh10^{1, 5}	11 (40.00 cM)⁵	myosin, heavy polypeptide 10, non-muscle^{1, 5}	89.57(n)¹ 99.09(a)¹	77579¹ NM_175260.2¹ NP_780469.1¹ AI839609⁵ AK019969⁵ (see all 28)

About this table Species with no ortholog for MYH10

ENSEMBL Gene Tree for MYH10

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for MYH10 gene

MYH11² MYH9²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/861 NCBI SNPs in MYH10 are shown (see all 861 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 247)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs961^1,2	A,C,F,H	8319657(-)	`ATATAT/CAGACA`	1	--	ut3¹ ese³		5		MN EU EA WA	596
	rs11650137^1,2	A,C,F,H	8317926(+)	`AATGTA/CCTGGA`	1	--	ng5¹		8		EA NA EU WA	634
--	rs10520^1,2	A,C,F	8318991(-)	`CTCCCC/TATCGC`	1	--	ut3¹		3		MN EA	1634
--	rs962^1,2	A,C,F	8319418(-)	`CCGACG/GA /T/TCCTCAG`	1	--	ut3¹ ese³		3		EA MN	4644
--	rs1042567^1,2	A,C	8319418(-)	`CGACTA/CCTCAG`	1	--	ut3¹ ese³		1		MN	184
--	rs2047487^1,2	C	8318990(-)	`TCCCCA/GTCGCC`	1	--	ut3¹		0	--	--	--	--
	rs8067456^1,2	A,C,F,H	8364995(+)	`ACACCA/GTTACA`	1	N/N	syn¹		8		NA EU EA WA	632
	rs11374^1,2	C,F,H	8357626(+)	`ACCTTC/TGTCTG`	1	T/T	syn¹		8		MN EA EU WA NA	2342
	rs2291718^1,2	F,H	8348856(+)	`TTCTCG/AGATTC`	1	S/S	syn¹ ese³		5		EA EU WA	1902
	rs2270742^1,2	H	8336508(-)	`GAAGAG/ACGGGA`	1	E/E	syn¹ ese³		4		EU EA WA	420

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HapMap Linkage Disequilibrium images for MYH10 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 160776

1 Novoseek disease relationship for MYH10 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0.00	2	12874274 (1), 11244504 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/60 PubMed articles for MYH10 gene (see all 60 ):

Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes. (PubMed id 1860190)^{2, 3, 4} Simons M.... Weir L. (1991)
Neuronal cell expression of inserted isoforms of vertebrate nonmuscle myosin heavy chain II-B. (PubMed id 7782316)^{1, 3, 4} Itoh K. and Adelstein R.S. (1995)
Cloning of the cDNA encoding human nonmuscle myosin heavy chain-B and analysis of human tissues with isoform-specific antibodies. (PubMed id 7499478)^{1, 3, 4} Phillips C.L.... Adelstein R.S. (1995)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis. (PubMed id 7916668)^{3, 4} Aikawa M.... Periasamy M. (1993)
Estrogen modulation of MgATPase activity of nonmuscle myosin-II-B filaments. (PubMed id 17023528)^{1, 3} Gorodeski G.I. (2007)
Characterization of the nonmuscle myosin heavy chain IIB promoter: regulation by E2F. (PubMed id 8931991)^{1, 3} Weir L. and Chen D. (1996)
Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C. (PubMed id 15845534)^{1, 3} Kim K.Y....Adelstein R.S. (2005)
Protein kinase Cgamma regulates myosin IIB phosphorylation, cellular localization, and filament assembly. (PubMed id 16394101)^{1, 3} Rosenberg M. and Ravid S. (2006)
Neuron-specific alternative splicing of nonmuscle myosin II heavy chain-B pre-mRNA requires a cis-acting intron sequence. (PubMed id 8663598)^{1, 3} Kawamoto S. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4628	HGNC: 7568	AceView: MYH10	Ensembl:ENSG00000133026	euGenes: HUgn4628
ECgene: MYH10	H-InvDB: MYH10

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for MYH10	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MYH10
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for MYH10:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MYH10-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MYH10		Antibodies for MYH10
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MYH10		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for MYH10 (Myosin 2b)

	Recombinant Proteins (non-muscle heavy chain Myosin)
	Antibodies (non-muscle heavy chain Myosin)

Search OriGene for MYH10

Tocris compounds for MYH10

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Search Novus for antibodies for MYH10

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MYH10 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for MYH10

Summaries
for MYH10

Genomic Location
for MYH10

Proteins
for MYH10

Protein Domains/
Families
for MYH10

Gene Function
for MYH10

Pathways & Interactions
for MYH10

Drugs & Compounds
for MYH10

Transcripts
for MYH10

Expression
for MYH10

Orthologs
for MYH10

Paralogs
for MYH10

SNPs/Variants
for MYH10

Disorders & Mutations
for MYH10

Medical News
for MYH10

Publications
for MYH10

Search for MYH10

Genome Databases showing MYH10

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MYH10 (Gene Symbol)
MGC134913
MGC134914
NMMHC-B
NMMHC-IIB
NMMHCB
Cellular myosin heavy chain, type B
Myosin heavy chain 10
Myosin heavy chain, non-muscle IIb
NMMHC II-b
Non-muscle myosin heavy chain B
Non-muscle myosin heavy chain IIb
cellular myosin heavy chain, type B type B
myosin heavy chain, nonmuscle type B
myosin, heavy chain 10, non-muscle
myosin, heavy polypeptide 10, non-muscle
near to the ATP binding region
nonmuscle myosin II heavy chain-B
nonmuscle myosin heavy chain IIB
nonmuscle myosin heavy chain-B

MYH10 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor MYH10

Summariesfor MYH10

Genomic Locationfor MYH10

Proteinsfor MYH10

Protein Domains/Familiesfor MYH10

Gene Functionfor MYH10

Pathways & Interactionsfor MYH10

Drugs & Compoundsfor MYH10

Transcriptsfor MYH10

Expression for MYH10

Orthologsfor MYH10

Paralogsfor MYH10

SNPs/Variantsfor MYH10

Disorders & Mutationsfor MYH10

Medical Newsfor MYH10

Publicationsfor MYH10

Search for MYH10

Genome Databases showing MYH10

Other Databases showing MYH10

Specialized Databases showing MYH10

Licensable Technologiesfor MYH10

Servicesfor MYH10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MYH10

Summaries
for MYH10

Genomic Location
for MYH10

Proteins
for MYH10

Protein Domains/
Families
for MYH10

Gene Function
for MYH10

Pathways & Interactions
for MYH10

Drugs & Compounds
for MYH10

Transcripts
for MYH10

Expression
for MYH10

Orthologs
for MYH10

Paralogs
for MYH10

SNPs/Variants
for MYH10

Disorders & Mutations
for MYH10

Medical News
for MYH10

Publications
for MYH10

Licensable Technologies
for MYH10

Services
for MYH10