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MYH10 Gene

protein-coding   GIFtS: 68
GCID: GC17M008318

Myosin, Heavy Chain 10, Non-Muscle

(Previous names: myosin, heavy polypeptide 10, non-muscle)
  Search for MYH10
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myosin, Heavy Chain 10, Non-Muscle1 2     Nonmuscle Myosin II Heavy Chain-B2
Myosin, Heavy Polypeptide 10, Non-Muscle1 2     NMMHC-B3
Cellular Myosin Heavy Chain, Type B2 3     Myosin Heavy Chain 103
NMMHC-IIB2 3     Myosin Heavy Chain, Non-Muscle IIb3
NMMHCB2     NMMHC II-B3
Myosin Heavy Chain, Nonmuscle Type B2     Non-Muscle Myosin Heavy Chain B3
myosin-102     Non-Muscle Myosin Heavy Chain IIb3
Nonmuscle Myosin Heavy Chain IIB2     

External Ids:    HGNC: 75681   Entrez Gene: 46282   Ensembl: ENSG000001330267   OMIM: 1607765   UniProtKB: P355803   

Export aliases for MYH10 gene to outside databases

Previous GC identifers: GC17M008754 GC17M009471 GC17M008320 GC17M008579 GC17M008580


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYH10 Gene:
This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it
should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with
diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene
have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for MYH10 Gene:
MYH10 (myosin, heavy chain 10, non-muscle) is a protein-coding gene. GO annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is MYH8.

UniProtKB/Swiss-Prot: MYH10_HUMAN, P35580
Function: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such
as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the
central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically
antagonized by MYH9

summary for MYH10 Gene:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYH10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYH10 gene promoter:
         STAT5B   PPAR-alpha   Spz1   MyoD   FOXJ2   IRF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYH10 promoter sequence
   Search Chromatin IP Primers for MYH10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYH10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13

MYH10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYH10 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M008318:  view genomic region     (about GC identifiers)

Start:
8,377,523 bp from pter      End:
8,534,079 bp from pter
Size:
156,557 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MYH10_HUMAN, P35580 (See protein sequence)
Recommended Name: Myosin-10  
Size: 1976 amino acids; 228999 Da
Subunit: Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain
subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with PLEKHG6. Interacts with ECM29.
Interacts with KIF26B (By similarity). Interacts with LARP6. Interacts with MCC
Caution: Represents a conventional non-muscle myosin. This protein should not be confused with the unconventional
myosin-10 (MYO10)
Sequence caution: Sequence=BAE06108.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: F8VTL3 Q12989 Q149N3 Q149N4 Q16087 Q4LE45 Q6PK16
Alternative splicing: 4 isoforms:  P35580-1   P35580-2   P35580-3   P35580-4   (No experimental confirmation available. Contains a phosphoserine at position 214)

Explore the universe of human proteins at neXtProt for MYH10: NX_P35580

Explore proteomics data for MYH10 at MOPED

Post-translational modifications: 

  • Phosphorylated by ABL2 (By similarity)1
  • Ubiquitination2 at Lys232, Lys410, Lys689, Lys738, Lys767, Lys817, Lys840, Lys842, Lys1452, Lys1800
  • Modification sites at PhosphoSitePlus

  • See MYH10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001242941.1  NP_001243024.1  NP_005955.3  

    ENSEMBL proteins: 
     ENSP00000353590   ENSP00000269243   ENSP00000408220   ENSP00000379539   ENSP00000369315  
    Reactome Protein details: P35580

    MYH10 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for MYH10

     
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    MYH10 Assay Products:

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    Cloud-Clone Corp. ELISAs for MYH10
    Cloud-Clone Corp. CLIAs for MYH10
    Search eBioscience for ELISAs for MYH10 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MYHII: Myosins / Myosin superfamily : Class II

    Selected InterPro protein domains (see all 7):
     IPR027401 Myosin-like_IQ_dom
     IPR008989 Myosin_S1_N
     IPR004009 Myosin_N
     IPR027417 P-loop_NTPase
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry P35580

    ProtoNet protein and cluster: P35580

    4 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB002017 Spectrin repeat
    IPB002928 Myosin tail
    IPB004009 Myosin N-terminal SH3-like domain


    UniProtKB/Swiss-Prot: MYH10_HUMAN, P35580
    Domain: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of
    4 heptapeptides, characteristic for alpha-helical coiled coils
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 myosin head-like domain


    Find genes that share domains with MYH10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYH10_HUMAN, P35580
    Function: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such
    as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
    During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the
    central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically
    antagonized by MYH9

         Genatlas biochemistry entry for MYH10:
    myosin,motor contractile protein moving towards the "plus" end of actin track,heavy polypeptide 10,non muscle

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000146microfilament motor activity IDA15845534
    GO:0003774motor activity ----
    GO:0003779actin binding NAS7782316
    GO:0005515protein binding IPI7542763
    GO:0005516calmodulin binding IEA--
         
    Find genes that share ontologies with MYH10           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MYH10:
     Decreased cilium length after  

         13 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Myh10):
     behavior/neurological  cardiovascular system  cellular  craniofacial  growth/size/body 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 
     nervous system  skeleton  vision/eye 

    Find genes that share phenotypes with MYH10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MYH10: Myh10tm1Rsad Myh10tm4Rsad Myh10tm2Rsad Myh10tm5Rsad

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYH10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MYH10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYH10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYH10

    miRNA
    Products:
        
    miRTarBase miRNAs that target MYH10:
    hsa-mir-197-3p (MIRT048126), hsa-mir-92b-3p (MIRT040548), hsa-mir-23a-3p (MIRT050395), hsa-mir-505-3p (MIRT041051), hsa-mir-106b-3p (MIRT038556), hsa-mir-26a-5p (MIRT050174), hsa-mir-1274a (MIRT035841)

    Block miRNA regulation of human, mouse, rat MYH10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYH10 (see all 88):
    hsa-miR-3678-3p hsa-miR-300 hsa-miR-200a hsa-miR-128 hsa-miR-30d hsa-miR-550a* hsa-miR-890 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidMYH10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MYH10
    Predesigned siRNA for gene silencing in human, mouse, rat MYH10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MYH10

    Clone
    Products:
         
    OriGene clones in human, mouse for MYH10 (see all 5)
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    GenScript: all cDNA clones in your preferred vector: MYH10 (NM_005964)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYH10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYH10
    Addgene plasmids for MYH10 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYH10_HUMAN, P35580: Cell projection, lamellipodium. Note=Colocalizes with MCC at the leading edge of migrating
    cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    plasma membrane2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IDA15774463
    GO:0005737cytoplasm IDA7699007
    GO:0005819spindle IEA--
    GO:0005886plasma membrane IEA--
    GO:0005938cell cortex IDA7699007

    Find genes that share ontologies with MYH10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYH10 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    2Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    3Cell adhesion Integrin mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Development MAG dependent inhibition of neurite outgrowth0.46
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cell adhesion Tight junctions0.33
    4PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    5Semaphorin interactions
    Sema4D in semaphorin signaling0.90
    Semaphorin interactions0.43
    Sema4D induced cell migration and growth-cone collapse0.90


    Find genes that share SuperPaths with MYH10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MYH10 (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions

    1 Cell Signaling Technology (CST) Pathway for MYH10
        Cytoskeletal Signaling

    Selected GeneGo (Thomson Reuters) Pathways for MYH10 (see all 6)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Tight junctions

    1 BioSystems Pathway for MYH10
        Regulation of Actin Cytoskeleton

    1 Reactome Pathway for MYH10
        Sema4D induced cell migration and growth-cone collapse


    3 Kegg Pathways  (Kegg details for MYH10):
        Tight junction
    Regulation of actin cytoskeleton
    Salmonella infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MYH10: 
              Cell Surface Markers in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MYH10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYH10 (P355802, 3 ENSP000002692434) via UniProtKB, MINT, STRING, and/or I2D (see all 240)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKBO149202, 3, ENSP000003391514MINT-48077 I2D: score=2 STRING: ENSP00000339151
    MAP3K1Q132332, 3, ENSP000003824234MINT-48299 I2D: score=2 STRING: ENSP00000382423
    TRPM6Q9BX842, 3, ENSP000003540064MINT-6699529 I2D: score=1 STRING: ENSP00000354006
    IKBKEQ141642, 3MINT-48102 I2D: score=4 
    IKBKGQ9Y6K92, 3MINT-48167 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000281mitotic cytokinesis IDA15774463
    GO:0001701in utero embryonic development IEA--
    GO:0001764neuron migration IEA--
    GO:0001778plasma membrane repair IEA--
    GO:0006200ATP catabolic process IMP--

    Find genes that share ontologies with MYH10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MYH10 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BTSSelective inhibitor of skeletal muscle myosin II ATPase activity[1576-37-0]
    (R)-(+)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)[1177356-70-5]
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)[856925-71-8]
    (+-)-BlebbistatinSelective inhibitor of myosin II ATPase activity[674289-55-5]

    3 Novoseek inferred chemical compound relationships for MYH10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    actomyosin 68.6 3 16901965 (1), 12605685 (1), 17023528 (1)
    estrogen 25.8 4 16901965 (2), 17023528 (2)
    atp 0.0441 1 8663598 (1)



    Find genes that share compounds with MYH10           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYH10 gene (3 alternative transcripts): 
    NM_001256012.1  NM_001256095.1  NM_005964.3  

    Unigene Cluster for MYH10:

    Myosin, heavy chain 10, non-muscle
    Hs.16355  [show with all ESTs]
    Unigene Representative Sequence: NM_001256012
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360416(uc002glm.3) ENST00000269243(uc002gll.3) ENST00000476737
    ENST00000488329 ENST00000465458 ENST00000469865 ENST00000584124 ENST00000459986
    ENST00000472728 ENST00000411957 ENST00000396239 ENST00000379980(uc010cnx.3 uc010cny.1)

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    Selected qRT-PCR Assays for microRNAs that regulate MYH10 (see all 88):
    hsa-miR-3678-3p hsa-miR-300 hsa-miR-200a hsa-miR-128 hsa-miR-30d hsa-miR-550a* hsa-miR-890 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidMYH10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MYH10
    Clone
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    OriGene clones in human, mouse for MYH10 (see all 5)
    OriGene ORF clones in mouse, rat for MYH10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MYH10 (NM_005964)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYH10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYH10
    Addgene plasmids for MYH10 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MYH10
      QuantiTect SYBR Green Assays in human, mouse, rat MYH10
      QuantiFast Probe-based Assays in human, mouse, rat MYH10

    Additional mRNA sequence: 

    AB210026.1 AB621820.1 AF086505.1 AK026977.1 BC000280.1 BC008968.2 BC117690.1 BC117691.1 
    BC144668.1 BC150634.1 DQ925667.1 M69181.1 S67247.1 U15618.1 U34304.1 

    20 DOTS entries:

    DT.219373  DT.100821046  DT.91719949  DT.91817109  DT.102837546  DT.219370  DT.120920828  DT.435880 
    DT.92434433  DT.99994616  DT.100821044  DT.92434421  DT.95235074  DT.95309574  DT.95343009  DT.97818271 
    DT.100821042  DT.40211646  DT.75158458  DT.91955343 

    Selected AceView cDNA sequences (see all 395):

    BQ575843 AI445824 BU172441 AI678861 BM729029 AW877037 BF195121 CF541342 
    CR602815 CB243057 AA669531 BM314857 BU735889 BF507359 AA306254 U34304 
    BM981822 W74368 BE383159 CB154893 BU166935 CA443268 BU170365 F09836 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MYH10 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                    -                                       
    SP4:                                                                                                                    -                                       
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26 ^ 27
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for MYH10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MYH10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCTCTCTA
    MYH10 Expression
    About this image


    MYH10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     NULL (Uncategorized)
             VEGF/bFGF-induced embryoid bodies
     
     Heart (Cardiovascular System)
    MYH10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYH10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.16355

    UniProtKB/Swiss-Prot: MYH10_HUMAN, P35580
    Tissue specificity: Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and
    retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MYH10: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYH10 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myh101 , 5 myosin, heavy polypeptide 10, non-muscle1, 5 89.57(n)1
    99.09(a)1
      11 (41.95 cM)5
    775791  NM_175260.21  NP_780469.11 
     686915595 
    chicken
    (Gallus gallus)
    Aves MYH101 myosin, heavy chain 10, non-muscle 83.09(n)
    95.71(a)
      396465  NM_205474.1  NP_990805.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYH106
    myosin, heavy chain 10, non-muscle
    90(a)
    1 ↔ 1
    2(104959896-105043660)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.8332 Xenopus laevis nonmuscle myosin heavy chain mRNA, complete more 79.66(n)    L09740.1 
    zebrafish
    (Danio rerio)
    Actinopterygii myh101 myosin, heavy chain 10, non-muscle 78.6(n)
    90.06(a)
      555454  XM_005165719.1  XP_005165776.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta zip1 , 3 NOT muscle attachment myosin ATPase3
    zipper1
    61(a)
    (best of 2)3
    61.45(n)1
    63.27(a)1
      380011  NM_079136.31  NP_523860.21 
    worm
    (Caenorhabditis elegans)
    Secernentea hcp-13
    nmy-11
    Expression: 2-cell embryo3
    nmy-11
    20(a)
    (best of 2)3
    57.21(n)1
    52.71(a)1
      V(6596826-6601602)3
    1805811  NM_076103.41  NP_508504.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MYO1(YHR023W)4 Type II myosin heavy chain, required for wild-type more   --   8(151666-157452) 856418  NP_011888.1 


    ENSEMBL Gene Tree for MYH10 (if available)
    TreeFam Gene Tree for MYH10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYH10 gene
    MYH82  MYH12  MYH22  MYH112  MYH142  MYH92  MYH132  MYH7B2  
    MYH42  MYH32  MYH152  MYH62  MYH72  
    Selected SIMAP similar genes for MYH10 using alignment to 8 protein entries:     MYH10_HUMAN (see all proteins) (see all similar genes):
    DKFZp686D10126    MYH9    MYH11    FLJ00279    MYH14    MYH2
    MYO9B    MYO18A    MYO9A    MYO1C    MYO5C    MYH4
    MYH8    MYH7    MYH1    MYO3B    MYH13    MYH6

    Find genes that share paralogs with MYH10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYH10 (see all 3294)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs784904761,2
    C,F--8377056(+) GAAATC/TGGCAT 3 -- ds50011Minor allele frequency- T:0.04NA 120
    rs1892932211,2
    --8377143(+) CATCAC/TTGAAT 3 -- ds50010--------
    rs768270491,2
    C--8377162(+) AGCATC/TTTCAA 3 -- ds50012Minor allele frequency- T:0.18NA EA 122
    rs116501371,2
    C,F,A,H--8377201(+) AATGTA/CCTGGA 3 -- ds500126Minor allele frequency- N:0.00EA NA NS WA 2566
    rs1815775881,2
    --8377237(+) GTGAGC/TTTCAT 3 -- ds50010--------
    rs1414540151,2
    --8377366(+) AGTTGA/GAGCCA 3 -- ds50010--------
    rs1867821711,2
    --8377377(+) GGACTA/GGCCTG 3 -- ds50010--------
    rs1131629571,2
    F--8377396(+) TCTGTC/TGTCTG 3 -- ds50012Minor allele frequency- T:0.02CSA WA 120
    rs1470024591,2
    --8377606(+) GCAGGC/TGCAAA 3 -- ut310--------
    rs1381369611,2
    --8377820(+) AGCACA/GTTGCA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for MYH10 (8377523 - 8534079 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MYH10 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1105639CNV Deletion17803354
    esv2715616CNV Deletion23290073
    esv2715615CNV Deletion23290073
    esv2715614CNV Deletion23290073
    esv2112361CNV Deletion18987734
    esv270828CNV Insertion20981092
    nsv510433CNV Loss20534489
    nsv907664CNV Loss21882294
    nsv111760CNV Loss16902084
    nsv510434CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYH10
    DNA2.0 Custom Variant and Variant Library Synthesis for MYH10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 160776    OMIM disorders: --


    Find genes that share disorders with MYH10           About GenesLikeMe

    1 Novoseek inferred disease relationship for MYH10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 12874274 (1), 11244504 (1)

    Genetic Association Database (GAD): MYH10
    Human Genome Epidemiology (HuGE) Navigator: MYH10 (2 documents)

    Export disorders for MYH10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYH10 gene, integrated from 10 sources (see all 116):
    (articles sorted by number of sources associating them with MYH10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes. (PubMed id 1860190)1, 2, 3 Simons M.... Weir L. (Circ. Res. 1991)
    2. Neuronal cell expression of inserted isoforms of vertebrate nonmuscle myosin heavy chain II-B. (PubMed id 7782316)1, 2, 9 Itoh K. and Adelstein R.S. (J. Biol. Chem. 1995)
    3. Cloning of the cDNA encoding human nonmuscle myosin heavy chain-B and analysis of human tissues with isoform-specific antibodies. (PubMed id 7499478)1, 2, 9 Phillips C.L.... Adelstein R.S. (J. Muscle Res. Cell Motil. 1995)
    4. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PubMed id 20682791)1, 2 Gorbea C.... Rechsteiner M. (J. Biol. Chem. 2010)
    5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis. (PubMed id 7916668)1, 2 Aikawa M.... Periasamy M. (Circ. Res. 1993)
    9. Estrogen modulation of MgATPase activity of nonmuscle myosin-II-B filaments. (PubMed id 17023528)1, 9 Gorodeski G.I. (Endocrinology 2007)
    10. Characterization of the nonmuscle myosin heavy chain IIB promoter: regulation by E2F. (PubMed id 8931991)1, 9 Weir L. and Chen D. (Gene Expr. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4628 HGNC: 7568 AceView: MYH10 Ensembl:ENSG00000133026 euGenes: HUgn4628
    ECgene: MYH10 Kegg: 4628 H-InvDB: MYH10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYH10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYH10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYH10 gene:
    Search GeneIP for patents involving MYH10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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