MYH10 Gene
protein-coding GIFtS: 65
GCID: GC17M008318
|
|
myosin, heavy chain 10, non-muscle(Previous names: myosin, heavy polypeptide 10, non-muscle )
| |
Aliases
for MYH10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Myosin, Heavy Chain 10, Non-Muscle1 2 | | Nonmuscle Myosin II Heavy Chain-B2 | | NMMHCB1 2 | | NMMHC-B3 | | Myosin, Heavy Polypeptide 10, Non-Muscle1 2 | | Myosin Heavy Chain 103 | | Cellular Myosin Heavy Chain, Type B2 3 | | Myosin Heavy Chain, Non-Muscle IIb3 | | NMMHC-IIB2 3 | | NMMHC II-B3 | | Myosin Heavy Chain, Nonmuscle Type B2 | | Non-Muscle Myosin Heavy Chain B3 | | Myosin-101 | | Non-Muscle Myosin Heavy Chain IIb3 | | Nonmuscle Myosin Heavy Chain IIB2 | | |
Export aliases for MYH10 gene to outside databasesPrevious GC identifers: GC17M008754 GC17M009471 GC17M008320 GC17M008579 GC17M008580 |
Summaries
for MYH10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MYH10:
This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; itshould not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins withdiverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene havebeen associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variantsencoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2011)
UniProtKB/Swiss-Prot: MYH10_HUMAN, P35580Function: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such assecretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2
 summary
for MYH10: Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.
Gene Wiki entry for MYH10
|
Genomic Views
for MYH10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MYH10 gene promoter:
STAT5B PPAR-alpha Spz1 MyoD FOXJ2 IRF-1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for MYH10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYH10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13MYH10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M008318: view genomic region
(about GC identifiers)
Start:
|
8,377,523 bp from pter |
End:
|
8,534,079 bp from pter |
Size:
|
156,557 bases |
Orientation:
|
minus strand |
|
Proteins
for MYH10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MYH10_HUMAN, P35580 (See
protein sequence)Recommended Name: Myosin-10 Size: 1976 amino acids; 228999 Da
Subunit: Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits(MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with PLEKHG6. Interacts with ECM29. Interacts withKIF26B (By similarity). Interacts with LARP6
Caution: Represents a conventional non-muscle myosin. This protein should not be confused with the unconventionalmyosin-10 (MYO10)
Sequence caution: Sequence=BAE06108.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: F8VTL3 Q12989 Q149N3 Q149N4 Q16087 Q4LE45 Q6PK16Alternative splicing: 4 isoforms: P35580-1 P35580-2 P35580-3 P35580-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MYH10: NX_P35580
Post-translational modifications:
Phosphorylated by ABL2 (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P35580
MYH10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001242941.1 NP_001243024.1 NP_005955.3
ENSEMBL proteins: ENSP00000353590 ENSP00000269243 ENSP00000408220 ENSP00000379539 ENSP00000369315 Reactome Protein details: P35580
Human Recombinant Protein Products for MYH10:
Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15): About this table
MYH10 for ontologies About GeneDecksing
MYH10 Antibody Products:
Assay Products for MYH10: |
Protein
Domains /
Families
for MYH10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MYH10 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P35580ProtoNet protein and cluster: P35580 4 Blocks protein families: IPB000048 IQ calmodulin-binding region IPB002017 Spectrin repeat IPB002928 Myosin tail IPB004009 Myosin N-terminal SH3-like domain
UniProtKB/Swiss-Prot: MYH10_HUMAN, P35580Domain: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4heptapeptides, characteristic for alpha-helical coiled coilsSimilarity: Contains 1 IQ domainSimilarity: Contains 1 myosin head-like domain |
Function
for MYH10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MYH10_HUMAN, P35580Function: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such assecretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2 Genatlas biochemistry entry for MYH10:myosin,motor contractile protein moving towards the "plus" end of actin track,heavy polypeptide 10,non muscle
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
MYH10 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for MYH10:
13 MGI mutant phenotypes (inferred from 8 alleles ) (MGI details for Myh10):
MYH10 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for MYH10: Myh10tm1Rsad Myh10tm4Rsad Myh10tm2Rsad Myh10tm5Rsad
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYH10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYH10
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MYH10 (NM_005964) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYH10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYH10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH10 |
|
Pathways & Interactions
for MYH10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell adhesion_Integrin-mediated cell adhesion and migration | | | 2 | Immune response _CCR3 signaling in eosinophils | | | 3 | PAK Pathway | | | 4 | Sema4D in semaphorin signaling | | | 5 | Axon guidance | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 EMD Millipore Pathways for MYH10
5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYH10 (see all 11)
1 
Cell Signaling Technology (CST) Pathway for MYH10
5/6  GeneGo (Thomson Reuters) Pathways for MYH10 (see all 6)
1  BioSystems Pathway for MYH10
5 
Reactome Pathways for MYH10
3 
Kegg Pathways (Kegg details for MYH10):
MYH10 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYH10
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/93 Interacting proteins for MYH10 (P355802, 3 ENSP000002692434) via UniProtKB, MINT, STRING, and/or I2D (see all 93)About this table
Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25): About this table
MYH10 for ontologies About GeneDecksing
|
Drugs & Compounds
for MYH10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MYH10 for compounds About GeneDecksing
Compounds for MYH10 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| (R)-(+)-Blebbistatin | Selective inhibitor of myosin II. Inactive enantiomer of (±)-blebbistatin (Cat. No. 1760) | -- | | (S)-(-)-Blebbistatin | Selective inhibitor of myosin II. Active enantiomer of (±)-blebbistatin (Cat. No. 1760) | [856925-71-8] | | (±)-Blebbistatin | Selective inhibitor of myosin II | [674289-55-5] |
3 Novoseek chemical compound relationships for MYH10 gene About this table
Search CenterWatch for drugs/clinical trials and news about MYH10
|
Transcripts
for MYH10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MYH10 gene (3 alternative transcripts): NM_001256012.1 NM_001256095.1 NM_005964.3 Unigene Cluster for MYH10: Myosin, heavy chain 10, non-muscle Hs.16355 [show with all ESTs]Unigene Representative Sequence: NM_00125601212 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000360416(uc002glm.3) ENST00000269243(uc002gll.3) ENST00000476737
ENST00000488329 ENST00000465458 ENST00000469865 ENST00000584124 ENST00000459986
ENST00000472728 ENST00000411957 ENST00000396239 ENST00000379980(uc010cnx.3 uc010cny.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYH10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYH10
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MYH10 (NM_005964) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MYH10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYH10 |
Additional cDNA sequence: AB210026.1 AB621820.1 AF086505.1 AK026977.1 BC000280.1 BC008968.2 BC117690.1 BC117691.1 BC144668.1 BC150634.1 DQ925667.1 M69181.1 S67247.1 U15618.1 U34304.1 20 DOTS entries: DT.219373 DT.100821046 DT.91719949 DT.91817109 DT.102837546 DT.219370 DT.120920828 DT.435880 DT.92434433 DT.99994616 DT.100821044 DT.92434421 DT.95235074 DT.95309574 DT.95343009 DT.97818271 DT.100821042 DT.40211646 DT.75158458 DT.91955343 24/395 AceView cDNA sequences (see all 395): CA435874 CB154893 AI277797 AA505470 BU166935 F04914 BC000280 U34304 BE383159 AA476595 BU173337 AI825348 W74368 AI678861 BQ425468 AA490700 N75446 BM729029 BQ575843 U15618 AI582253 T96820 CR602815 CB243057
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MYH10 (see all 13) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20 | ^ | 21a | · | 21b | · | 21c | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24 | ^ | 25a | · | 25b | ^ | 26 | ^ | 27 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MYH10
|
Expression
for MYH10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MYH10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACCTCTCTA
About this image
See MYH10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MYH10
SOURCE GeneReport for Unigene cluster: Hs.16355
UniProtKB/Swiss-Prot: MYH10_HUMAN, P35580Tissue specificity: Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum andretina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum
SABiosciences Expression via Pathway-Focused PCR Arrays including MYH10:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MYH10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MYH10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MYH10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYH10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYH10 |
Orthologs
for MYH10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MYH10 gene from 6/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MYH101 |
myosin, heavy chain 10, non-muscle |
83.01(n)
95.95(a) |
|
396465 NM_205474.1 NP_990805.1 |
lizard
(Anolis carolinensis) |
Reptilia |
MYH106 |
-- |
93(a) |
1 ↔ 1 |
2(104959907-105037471) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.8332 |
Xenopus laevis nonmuscle myosin heavy chain mRNA, complete more |
79.66(n) |
|
L09740.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
myh101 |
myosin, heavy polypeptide 10, non-muscle |
78.58(n)
90.22(a) |
|
555454 XM_677954.5 XP_683046.5 |
fruit fly
(Drosophila melanogaster) |
Insecta |
zip1 , 3 |
NOT muscle attachment myosin ATPase3
zipper1 |
61(a)
(best of 2)3
61.57(n)1
63.49(a)1 |
|
380011 NM_079136.31 NP_523860.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
hcp-13
nmy-11 |
Expression: 2-cell embryo3
Protein NMY-11 |
20(a)
(best of 2)3
57(n)1
52.52(a)1 |
|
V(6596826-6601602)3
1805811 NM_076103.31 NP_508504.21 |
ENSEMBL Gene Tree for MYH10 (if available)
TreeFam Gene Tree for MYH10 (if available) |
Paralogs
for MYH10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MYH10 gene
- MYH82 MYH12 MYH22 MYH112 MYH142 MYH92 MYH132 MYH7B2
- MYH42 MYH32 MYH152 MYH62 MYH72
18/37 SIMAP similar genes for MYH10 using alignment to 8 protein entries: MYH10_HUMAN (see all proteins)
(see all similar genes):DKFZp686D10126 MYH9 MYH11 FLJ00279 MYH14 MYH2
MYO18A MYO9A MYO1C MYO5C MYH4 MYH8
MYH7 MYH1 MYO3B MYH6 MYO10 MYH3
MYH10 for paralogs About GeneDecksing
|
Genomic Variants
for MYH10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MYH10 (8377523 - 8534079 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MYH10
1 Indel: 45618 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MYH10 |
|
Disorders
/ Diseases
for MYH10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MYH10 for disorders About GeneDecksing
OMIM gene information: 160776
OMIM disorders: --
15  diseases for MYH10: About MalaCardsmay-hegglin anomaly ventricular septal defect gitelman syndrome muscular dystrophy
kaposi's sarcoma lymphangioleiomyomatosis hydrocephalus vaginitis
sarcoma lung cancer atherosclerosis cervicitis
melanoma prostatitis neuronitis
1 Novoseek disease relationship for MYH10 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
2 |
12874274 (1), 11244504 (1) |
Human Genome Epidemiology (HuGE) Navigator: MYH10 (2 documents)
Export disorders for MYH10 gene to outside databases
|
Publications
for MYH10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MYH10 gene, integrated from 9 sources (see all 102):
(articles sorted by number of sources associating them with MYH10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes. (PubMed id 1860190)1, 2, 3 Simons M.... Weir L. (1991)
- Neuronal cell expression of inserted isoforms of vertebrate nonmuscle myosin heavy chain II-B. (PubMed id 7782316)1, 2, 9 Itoh K. and Adelstein R.S. (1995)
- Cloning of the cDNA encoding human nonmuscle myosin heavy chain-B and analysis of human tissues with isoform-specific antibodies. (PubMed id 7499478)1, 2, 9 Phillips C.L.... Adelstein R.S. (1995)
- A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PubMed id 20682791)1, 2 Gorbea C.... Rechsteiner M. (2010)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis. (PubMed id 7916668)1, 2 Aikawa M.... Periasamy M. (1993)
- Estrogen modulation of MgATPase activity of nonmuscle myosin-II-B filaments. (PubMed id 17023528)1, 9 Gorodeski G.I. (2007)
- Characterization of the nonmuscle myosin heavy chain IIB promoter: regulation by E2F. (PubMed id 8931991)1, 9 Weir L. and Chen D. (1996)
- Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C. (PubMed id 15845534)1, 9 Kim K.Y....Adelstein R.S. (2005)
- Protein kinase Cgamma regulates myosin IIB phosphorylation, cellular localization, and filament assembly. (PubMed id 16394101)1, 9 Rosenberg M. and Ravid S. (2006)
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External Searches for MYH10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing MYH10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing MYH10 gene
(According to HUGE)
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Specialized Databases showing MYH10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for MYH10 gene:
Search GeneIP for patents involving MYH10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MYH10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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