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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MYH10 Gene

protein-coding   GIFtS: 66
GCID: GC17M008318

Myosin, Heavy Chain 10, Non-Muscle

(Previous names: myosin, heavy polypeptide 10, non-muscle)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Myosin, Heavy Chain 10, Non-Muscle1 2     Nonmuscle Myosin II Heavy Chain-B2
Myosin, Heavy Polypeptide 10, Non-Muscle1 2     NMMHC-B3
Cellular Myosin Heavy Chain, Type B2 3     Myosin Heavy Chain 103
NMMHC-IIB2 3     Myosin Heavy Chain, Non-Muscle IIb3
NMMHCB2     NMMHC II-B3
Myosin Heavy Chain, Nonmuscle Type B2     Non-Muscle Myosin Heavy Chain B3
myosin-102     Non-Muscle Myosin Heavy Chain IIb3
Nonmuscle Myosin Heavy Chain IIB2     

External Ids:    HGNC: 75681   Entrez Gene: 46282   Ensembl: ENSG000001330267   OMIM: 1607765   UniProtKB: P355803   

Export aliases for MYH10 gene to outside databases

Previous GC identifers: GC17M008754 GC17M009471 GC17M008320 GC17M008579 GC17M008580


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYH10 Gene:
This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it
should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with
diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene
have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for MYH10 Gene: 
MYH10 (myosin, heavy chain 10, non-muscle) is a protein-coding gene. Diseases associated with MYH10 include gitelman syndrome, and ventricular septal defect, and among its related super-pathways are Regulation of actin cytoskeleton and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is MYH8.

UniProtKB/Swiss-Prot: MYH10_HUMAN, P35580
Function: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such
as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2

summary for MYH10 Gene:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYH10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYH10 gene promoter:
         STAT5B   PPAR-alpha   Spz1   MyoD   FOXJ2   IRF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYH10 promoter sequence
   Search SABiosciences Chromatin IP Primers for MYH10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYH10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13

MYH10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYH10 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M008318:  view genomic region     (about GC identifiers)

Start:
8,377,523 bp from pter      End:
8,534,079 bp from pter
Size:
156,557 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MYH10_HUMAN, P35580 (See protein sequence)
Recommended Name: Myosin-10  
Size: 1976 amino acids; 228999 Da
Subunit: Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain
subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with PLEKHG6. Interacts with ECM29.
Interacts with KIF26B (By similarity). Interacts with LARP6
Caution: Represents a conventional non-muscle myosin. This protein should not be confused with the unconventional
myosin-10 (MYO10)
Sequence caution: Sequence=BAE06108.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: F8VTL3 Q12989 Q149N3 Q149N4 Q16087 Q4LE45 Q6PK16
Alternative splicing: 4 isoforms:  P35580-1   P35580-2   P35580-3   P35580-4   (No experimental confirmation available. Contains a phosphoserine at position 214)

Explore the universe of human proteins at neXtProt for MYH10: NX_P35580

Explore proteomics data for MYH10 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by ABL2 (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P35580

  • MYH10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MYH10 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001242941.1  NP_001243024.1  NP_005955.3  

    ENSEMBL proteins: 
     ENSP00000353590   ENSP00000269243   ENSP00000408220   ENSP00000379539   ENSP00000369315  
    Reactome Protein details: P35580
    Human Recombinant Protein Products for MYH10: 
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    Cloud-Clone Corp. Proteins for MYH10 

    Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IDA15774463
    GO:0005737cytoplasm IDA7699007
    GO:0005819spindle IEA--
    GO:0005886plasma membrane IEA--
    GO:0005938cell cortex IDA7699007

    MYH10 for ontologies           About GeneDecksing



    MYH10 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MYHII: Myosins / Myosin superfamily : Class II

    5/7 InterPro protein domains (see all 7):
     IPR027401 Myosin-like_IQ_dom
     IPR008989 Myosin_S1_N
     IPR004009 Myosin_N
     IPR027417 P-loop_NTPase
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry P35580

    ProtoNet protein and cluster: P35580

    4 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB002017 Spectrin repeat
    IPB002928 Myosin tail
    IPB004009 Myosin N-terminal SH3-like domain


    UniProtKB/Swiss-Prot: MYH10_HUMAN, P35580
    Domain: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of
    4 heptapeptides, characteristic for alpha-helical coiled coils
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 myosin head-like domain


    MYH10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYH10_HUMAN, P35580
    Function: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such
    as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2

         Genatlas biochemistry entry for MYH10:
    myosin,motor contractile protein moving towards the "plus" end of actin track,heavy polypeptide 10,non muscle

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000146microfilament motor activity IDA15845534
    GO:0003774motor activity ----
    GO:0003779actin binding NAS7782316
    GO:0005515protein binding IPI7542763
    GO:0005516calmodulin binding IEA--
         
    MYH10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MYH10:
     Decreased cilium length after  

         13 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Myh10):
     behavior/neurological  cardiovascular system  cellular  craniofacial  growth/size 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 
     nervous system  skeleton  vision/eye 

    MYH10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MYH10: Myh10tm1Rsad Myh10tm4Rsad Myh10tm2Rsad Myh10tm5Rsad

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MYH10 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MYH10 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MYH10 About   (see all 17)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    2Immune response CCR3 signaling in eosinophils
    Immune response CCR3 signaling in eosinophils0.51
    Inhibitory action of Lipoxins on neutrophil migration0.51
    3PAK Pathway
    PAK Pathway0.56
    Epithelial Adherens Junctions0.36
    Antioxidant Action of Vitamin-C0.56
    4Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin-mediated cell adhesion and migration0.49
    Cell adhesion Tight junctions0.33
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    5Sema4D in semaphorin signaling
    Sema4D in semaphorin signaling0.89
    Semaphorin interactions0.41
    Sema4D induced cell migration and growth-cone collapse0.89

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for MYH10
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils
    Development MAG-dependent inhibition of neurite outgrowth

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYH10 (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions

    1 Cell Signaling Technology (CST) Pathway for MYH10
        Cytoskeletal Signaling

    5/6 GeneGo (Thomson Reuters) Pathways for MYH10 (see all 6)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Tight junctions

    1 BioSystems Pathway for MYH10
        Regulation of Actin Cytoskeleton

    5        Reactome Pathways for MYH10
        Developmental Biology
    Sema4D induced cell migration and growth-cone collapse
    Semaphorin interactions
    Sema4D in semaphorin signaling
    Axon guidance


    4         Kegg Pathways  (Kegg details for MYH10):
        Tight junction
    Regulation of actin cytoskeleton
    Salmonella infection
    Viral myocarditis


    MYH10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYH10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/97 Interacting proteins for MYH10 (P355802, 3 ENSP000002692434) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRPM6Q9BX842, 3, ENSP000003540064MINT-6699529 I2D: score=1 STRING: ENSP00000354006
    IKBKEQ141642, 3MINT-48102 I2D: score=4 
    IKBKGQ9Y6K92, 3MINT-48167 I2D: score=2 
    MAP3K1Q132332, 3MINT-48299 I2D: score=2 
    MAP3K3Q997592, 3MINT-48425 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000281mitotic cytokinesis IDA15774463
    GO:0001701in utero embryonic development IEA--
    GO:0001764neuron migration IEA--
    GO:0001778plasma membrane repair IEA--
    GO:0006887exocytosis IEA--

    MYH10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MYH10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MYH10 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BTSSelective inhibitor of skeletal muscle myosin II ATPase activity[1576-37-0]
    (R)-(+)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760)[1177356-70-5]
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760)[856925-71-8]
    (+-)-BlebbistatinSelective inhibitor of myosin II ATPase activity[674289-55-5]

    3 Novoseek inferred chemical compound relationships for MYH10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    actomyosin 68.6 3 16901965 (1), 12605685 (1), 17023528 (1)
    estrogen 25.8 4 16901965 (2), 17023528 (2)
    atp 0.0441 1 8663598 (1)

    Search CenterWatch for drugs/clinical trials and news about MYH10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for MYH10 gene (3 alternative transcripts): 
    NM_001256012.1  NM_001256095.1  NM_005964.3  

    Unigene Cluster for MYH10:

    Myosin, heavy chain 10, non-muscle
    Hs.16355  [show with all ESTs]
    Unigene Representative Sequence: NM_001256012
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360416(uc002glm.3) ENST00000269243(uc002gll.3) ENST00000476737
    ENST00000488329 ENST00000465458 ENST00000469865 ENST00000584124 ENST00000459986
    ENST00000472728 ENST00000411957 ENST00000396239 ENST00000379980(uc010cnx.3 uc010cny.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB210026.1 AB621820.1 AF086505.1 AK026977.1 BC000280.1 BC008968.2 BC117690.1 BC117691.1 
    BC144668.1 BC150634.1 DQ925667.1 M69181.1 S67247.1 U15618.1 U34304.1 

    20 DOTS entries:

    DT.219373  DT.100821046  DT.91719949  DT.91817109  DT.102837546  DT.219370  DT.120920828  DT.435880 
    DT.92434433  DT.99994616  DT.100821044  DT.92434421  DT.95235074  DT.95309574  DT.95343009  DT.97818271 
    DT.100821042  DT.40211646  DT.75158458  DT.91955343 

    24/395 AceView cDNA sequences (see all 395):

    AI277790 BU182128 BC008968 BQ575843 T07180 BQ189148 AA340297 AW877037 
    AV708215 N75446 F01973 BM682574 F02570 AA490700 U34304 N91258 
    CB243057 CD644420 CA443268 BQ425468 BQ227385 BM314857 BU735889 F06285 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MYH10 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                    -                                       
    SP4:                                                                                                                    -                                       
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26 ^ 27
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for MYH10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYH10 expression in normal human tissues (normalized intensities)      MYH10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCTCTCTA
    MYH10 Expression
    About this image


    MYH10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Endothelium (Cardiovascular System)
             Peripheral blood endothelial colony-forming cells
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical cord blood-derived hematopoietic stem cells
     
     Placenta (Extraembryonic Tissues)
             Decidua-derived mesenchymal cells
     
     Blood (Hematopoietic System)
             Umbilical cord blood-derived hematopoietic stem cells
     
     Mesenchymal Stem Cells (Muscoskeletal System)
             Decidua-derived mesenchymal cells

    See MYH10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYH10

    SOURCE GeneReport for Unigene cluster: Hs.16355

    UniProtKB/Swiss-Prot: MYH10_HUMAN, P35580
    Tissue specificity: Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and
    retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum

        SABiosciences Expression via Pathway-Focused PCR Arrays including MYH10: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MYH10 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myh101 , 5 myosin, heavy polypeptide 10, non-muscle1, 5 89.57(n)1
    99.09(a)1
      11 (41.95 cM)5
    775791  NM_175260.21  NP_780469.11 
     686915595 
    chicken
    (Gallus gallus)
    Aves MYH101 myosin, heavy chain 10, non-muscle 83.01(n)
    95.95(a)
      396465  NM_205474.1  NP_990805.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYH106
    Uncharacterized protein
    90(a)
    1 ↔ 1
    2(104959896-105043660)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.8332 Xenopus laevis nonmuscle myosin heavy chain mRNA, complete more 79.66(n)    L09740.1 
    zebrafish
    (Danio rerio)
    Actinopterygii myh101 myosin, heavy polypeptide 10, non-muscle 78.58(n)
    90.22(a)
      555454  XM_677954.5  XP_683046.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta zip1 , 3 NOT muscle attachment myosin ATPase3
    zipper1
    61(a)
    (best of 2)3
    61.57(n)1
    63.49(a)1
      380011  NM_079136.31  NP_523860.21 
    worm
    (Caenorhabditis elegans)
    Secernentea hcp-13
    nmy-11
    Expression: 2-cell embryo3
    Protein NMY-11
    20(a)
    (best of 2)3
    57(n)1
    52.52(a)1
      V(6596826-6601602)3
    1805811  NM_076103.31  NP_508504.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MYO1(YHR023W)4 Type II myosin heavy chain, required for wild-type more   --   8(151666-157452) 856418  NP_011888.1 


    ENSEMBL Gene Tree for MYH10 (if available)
    TreeFam Gene Tree for MYH10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYH10 gene
    MYH82  MYH12  MYH22  MYH112  MYH142  MYH92  MYH132  MYH7B2  
    MYH42  MYH32  MYH152  MYH62  MYH72  
    18/38 SIMAP similar genes for MYH10 using alignment to 8 protein entries:     MYH10_HUMAN (see all proteins) (see all similar genes):
    DKFZp686D10126    MYH9    MYH11    FLJ00279    MYH14    MYH2
    MYO9B    MYO18A    MYO9A    MYO1C    MYO5C    MYH4
    MYH8    MYH7    MYH1    MYO3B    MYH6    MYO10

    MYH10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3294 SNPs in MYH10 are shown (see all 3294)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs784904761,2
    C,F--8377056(+) GAAATC/TGGCAT 3 -- ds50011Minor allele frequency- T:0.04NA 120
    rs1892932211,2
    --8377143(+) CATCAC/TTGAAT 3 -- ds50010--------
    rs768270491,2
    C--8377162(+) AGCATC/TTTCAA 3 -- ds50012Minor allele frequency- T:0.18NA EA 122
    rs116501371,2
    C,F,A,H--8377201(+) AATGTA/CCTGGA 3 -- ds500126Minor allele frequency- N:0.00EA NA NS WA 2566
    rs1815775881,2
    --8377237(+) GTGAGC/TTTCAT 3 -- ds50010--------
    rs1414540151,2
    --8377366(+) AGTTGA/GAGCCA 3 -- ds50010--------
    rs1867821711,2
    --8377377(+) GGACTA/GGCCTG 3 -- ds50010--------
    rs1131629571,2
    F--8377396(+) TCTGTC/TGTCTG 3 -- ds50012Minor allele frequency- T:0.02CSA WA 120
    rs1470024591,2
    --8377606(+) GCAGGC/TGCAAA 3 -- ut310--------
    rs1381369611,2
    --8377820(+) AGCACA/GTTGCA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for MYH10 (8377523 - 8534079 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for MYH10 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1105639CNV Deletion17803354
    esv2715616CNV Deletion23290073
    esv2715615CNV Deletion23290073
    esv2715614CNV Deletion23290073
    esv2112361CNV Deletion18987734
    esv270828CNV Insertion20981092
    nsv510433CNV Loss20534489
    nsv907664CNV Loss21882294
    nsv111760CNV Loss16902084
    nsv510434CNV Loss20534489

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 160776    OMIM disorders: --

    16 diseases for MYH10:    About MalaCards
    gitelman syndrome    ventricular septal defect    lymphangioleiomyomatosis    hydrocephalus
    vaginitis    keloids    myocarditis    narcolepsy
    kaposi's sarcoma    muscular dystrophy    sarcoma    atherosclerosis
    cervicitis    melanoma    neuronitis    prostatitis


    MYH10 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MYH10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 12874274 (1), 11244504 (1)

    Genetic Association Database (GAD): MYH10
    Human Genome Epidemiology (HuGE) Navigator: MYH10 (2 documents)

    Export disorders for MYH10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYH10 gene, integrated from 9 sources (see all 113):
    (articles sorted by number of sources associating them with MYH10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes. (PubMed id 1860190)1, 2, 3 Simons M.... Weir L. (1991)
    2. Neuronal cell expression of inserted isoforms of vertebrate nonmuscle myosin heavy chain II-B. (PubMed id 7782316)1, 2, 9 Itoh K. and Adelstein R.S. (1995)
    3. Cloning of the cDNA encoding human nonmuscle myosin heavy chain-B and analysis of human tissues with isoform-specific antibodies. (PubMed id 7499478)1, 2, 9 Phillips C.L.... Adelstein R.S. (1995)
    4. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PubMed id 20682791)1, 2 Gorbea C.... Rechsteiner M. (2010)
    5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis. (PubMed id 7916668)1, 2 Aikawa M.... Periasamy M. (1993)
    9. Estrogen modulation of MgATPase activity of nonmuscle myosin-II-B filaments. (PubMed id 17023528)1, 9 Gorodeski G.I. (2007)
    10. Characterization of the nonmuscle myosin heavy chain IIB promoter: regulation by E2F. (PubMed id 8931991)1, 9 Weir L. and Chen D. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4628 HGNC: 7568 AceView: MYH10 Ensembl:ENSG00000133026 euGenes: HUgn4628
    ECgene: MYH10 Kegg: 4628 H-InvDB: MYH10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYH10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MYH10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MYH10 gene:
    Search GeneIP for patents involving MYH10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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