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Aliases for MYH10 Gene

Aliases for MYH10 Gene

  • Myosin Heavy Chain 10 2 3 4 5
  • Myosin, Heavy Polypeptide 10, Non-Muscle 2 3
  • Cellular Myosin Heavy Chain, Type B 3 4
  • NMMHC-IIB 3 4
  • Myosin Heavy Chain, Nonmuscle Type B 3
  • Myosin, Heavy Chain 10, Non-Muscle 3
  • Myosin Heavy Chain, Non-Muscle IIb 4
  • Nonmuscle Myosin II Heavy Chain-B 3
  • Non-Muscle Myosin Heavy Chain IIb 4
  • Nonmuscle Myosin Heavy Chain IIB 3
  • Non-Muscle Myosin Heavy Chain B 4
  • NMMHC II-B 4
  • Myosin-10 3
  • NMMHC-B 4
  • NMMHCB 3

External Ids for MYH10 Gene

Previous GeneCards Identifiers for MYH10 Gene

  • GC17M008754
  • GC17M009471
  • GC17M008320
  • GC17M008579
  • GC17M008580
  • GC17M008318

Summaries for MYH10 Gene

Entrez Gene Summary for MYH10 Gene

  • This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for MYH10 Gene

MYH10 (Myosin Heavy Chain 10) is a Protein Coding gene. Diseases associated with MYH10 include May-Hegglin Anomaly and Lymphangioleiomyomatosis. Among its related pathways are Semaphorin interactions and Tight junction. GO annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is MYH9.

UniProtKB/Swiss-Prot for MYH10 Gene

  • Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9.

Tocris Summary for MYH10 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.

Gene Wiki entry for MYH10 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYH10 Gene

Genomics for MYH10 Gene

Regulatory Elements for MYH10 Gene

Enhancers for MYH10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F008487 0.5 ENCODE 16.9 +142.0 141968 2.4 PAF1 CTCF PKNOX1 MAZ BHLHE40 DPF2 ZIC2 RAD21 ZFHX2 GLIS1 MYH10 RNU7-43P NDEL1 PIR59191 LOC102724262
GH17F008580 1.1 Ensembl ENCODE 16 +49.7 49665 1.8 PKNOX1 CBX3 MTA2 JUNB TBX21 ZNF316 ZNF157 IKZF1 ZNF24 NFE2 MYH10 CCDC42 SPDYE4 HES7 VAMP2 GC17P008561
GH17F008695 1.2 FANTOM5 Ensembl ENCODE 14.8 -66.7 -66673 3.6 CTCF NRF1 BHLHE40 JUNB KLF4 ZNF2 NR2F2 ZFHX2 IKZF1 FOXP2 MYH10 CCDC42 SPDYE4 LOC105371526 LOC105371525
GH17F008726 1.4 Ensembl ENCODE 12.1 -96.0 -96046 1.3 PKNOX1 ATF1 ARID4B SIN3A GLI4 FEZF1 DMAP1 ZNF2 ZNF48 YY1 ENSG00000271029 MYH10 SPDYE4 LOC105371523 CCDC42 LOC105371517 PFAS BORCS6 PIR61588 LOC105371529
GH17F008723 0.4 ENCODE 12.1 -93.7 -93677 2.2 HDAC1 PKNOX1 ARNT CEBPB KAT8 KLF16 SMARCA4 GLIS1 PBX2 IKZF1 CCDC42 MYH10 SPDYE4 RNF222 BORCS6 PIR61588 LOC105371529
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MYH10 on UCSC Golden Path with GeneCards custom track

Promoters for MYH10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001340530 712 3401 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for MYH10 Gene

Chromosome:
17
Start:
8,474,205 bp from pter
End:
8,631,012 bp from pter
Size:
156,808 bases
Orientation:
Minus strand

Genomic View for MYH10 Gene

Genes around MYH10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYH10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYH10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYH10 Gene

Proteins for MYH10 Gene

  • Protein details for MYH10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35580-MYH10_HUMAN
    Recommended name:
    Myosin-10
    Protein Accession:
    P35580
    Secondary Accessions:
    • B2RWP9
    • D3DTS1
    • F8VTL3
    • Q12989
    • Q149N3
    • Q149N4
    • Q16087
    • Q4LE45
    • Q6PK16
    • Q9BWG0

    Protein attributes for MYH10 Gene

    Size:
    1976 amino acids
    Molecular mass:
    228999 Da
    Quaternary structure:
    • Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with PLEKHG6. Interacts with ECM29. Interacts with KIF26B (By similarity). Interacts with LARP6. Interacts with MCC.
    SequenceCaution:
    • Sequence=BAE06108.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MYH10 Gene

    Alternative splice isoforms for MYH10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYH10 Gene

Post-translational modifications for MYH10 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MYH10 (MYH10)
  • Cloud-Clone Corp. Antibodies for MYH10

No data available for DME Specific Peptides for MYH10 Gene

Domains & Families for MYH10 Gene

Gene Families for MYH10 Gene

Graphical View of Domain Structure for InterPro Entry

P35580

UniProtKB/Swiss-Prot:

MYH10_HUMAN :
  • The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
  • Contains 1 IQ domain.
  • Contains 1 myosin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYH10: view

Function for MYH10 Gene

Molecular function for MYH10 Gene

GENATLAS Biochemistry:
myosin,motor contractile protein moving towards the "plus" end of actin track,heavy polypeptide 10,non muscle
UniProtKB/Swiss-Prot Function:
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9.

Gene Ontology (GO) - Molecular Function for MYH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000146 microfilament motor activity IDA 15845534
GO:0000166 nucleotide binding IEA --
GO:0003774 motor activity IEA --
GO:0003779 actin binding NAS 7782316
GO:0005515 protein binding IPI 7542763
genes like me logo Genes that share ontologies with MYH10: view
genes like me logo Genes that share phenotypes with MYH10: view

Animal Models for MYH10 Gene

MGI Knock Outs for MYH10:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYH10 Gene

Localization for MYH10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYH10 Gene

Cell projection, lamellipodium. Note=Colocalizes with MCC at the leading edge of migrating cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYH10 Gene COMPARTMENTS Subcellular localization image for MYH10 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
mitochondrion 5
nucleus 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MYH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 7699007
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IDA 7699007
GO:0005739 mitochondrion IDA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with MYH10: view

Pathways & Interactions for MYH10 Gene

genes like me logo Genes that share pathways with MYH10: view

SIGNOR curated interactions for MYH10 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MYH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IDA 15774463
GO:0001701 in utero embryonic development IEA --
GO:0001764 neuron migration IEA --
GO:0001778 plasma membrane repair IEA --
GO:0003279 cardiac septum development IEA --
genes like me logo Genes that share ontologies with MYH10: view

Drugs & Compounds for MYH10 Gene

(4) Drugs for MYH10 Gene - From: Tocris and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(R)-(+)-Blebbistatin Pharma non-muscle myosin II ATPases inhibitor, cell-permeable, Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 0
BTS Pharma Selective inhibitor of skeletal muscle myosin II ATPase activity 0

(3) Additional Compounds for MYH10 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-Blebbistatin
674289-55-5
(S)-(-)-Blebbistatin
856925-71-8

(4) Tocris Compounds for MYH10 Gene

Compound Action Cas Number
(+-)-Blebbistatin Selective inhibitor of myosin II ATPase activity 674289-55-5
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 1177356-70-5
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760) 856925-71-8
BTS Selective inhibitor of skeletal muscle myosin II ATPase activity 1576-37-0
genes like me logo Genes that share compounds with MYH10: view

Transcripts for MYH10 Gene

Unigene Clusters for MYH10 Gene

Myosin, heavy chain 10, non-muscle:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYH10 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1:
SP2:
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: - -
SP11:
SP12:
SP13:

ExUns: 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26 ^ 27
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MYH10 Gene

GeneLoc Exon Structure for
MYH10
ECgene alternative splicing isoforms for
MYH10

Expression for MYH10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYH10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYH10 Gene

This gene is overexpressed in Artery - Aorta (x15.0), Artery - Coronary (x6.6), and Artery - Tibial (x4.0).

Protein differential expression in normal tissues from HIPED for MYH10 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYH10 Gene



Protein tissue co-expression partners for MYH10 Gene

NURSA nuclear receptor signaling pathways regulating expression of MYH10 Gene:

MYH10

SOURCE GeneReport for Unigene cluster for MYH10 Gene:

Hs.16355

mRNA Expression by UniProt/SwissProt for MYH10 Gene:

P35580-MYH10_HUMAN
Tissue specificity: Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum.
genes like me logo Genes that share expression patterns with MYH10: view

Primer Products

Orthologs for MYH10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYH10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYH10 34 35
  • 99.58 (n)
oppossum
(Monodelphis domestica)
Mammalia MYH10 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYH10 34 35
  • 90.77 (n)
dog
(Canis familiaris)
Mammalia MYH10 34 35
  • 90.35 (n)
mouse
(Mus musculus)
Mammalia Myh10 34 16 35
  • 89.57 (n)
rat
(Rattus norvegicus)
Mammalia Myh10 34
  • 89.29 (n)
chicken
(Gallus gallus)
Aves MYH10 34 35
  • 83.09 (n)
lizard
(Anolis carolinensis)
Reptilia MYH10 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493774 34
  • 71.03 (n)
Str.20258 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.833 34
zebrafish
(Danio rerio)
Actinopterygii myh10 34 35
  • 78.6 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007523 34
  • 62.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta zip 36 34 35
  • 61.45 (n)
CG3493 36
  • 22 (a)
worm
(Caenorhabditis elegans)
Secernentea nmy-1 34 35
  • 57.21 (n)
nmy-2 35
  • 44 (a)
ManyToMany
hcp-1 36
  • 20 (a)
hcp-2 36
  • 19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO1 35 37
  • 30 (a)
OneToMany
Species where no ortholog for MYH10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYH10 Gene

ENSEMBL:
Gene Tree for MYH10 (if available)
TreeFam:
Gene Tree for MYH10 (if available)

Paralogs for MYH10 Gene

Variants for MYH10 Gene

Sequence variations from dbSNP and Humsavar for MYH10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs797044880 Pathogenic 8,512,588(-) CAGAA(G/T)AGATG intron-variant, reference, stop-gained
rs727504230 Uncertain significance 8,513,561(-) TGGAG(G/T)AGATG intron-variant, reference, stop-gained
rs727504231 Uncertain significance 8,552,127(-) AGTCT(C/T)GTGCT reference, missense
rs10048190 -- 8,585,100(+) GGCCT(C/T)CCAAA intron-variant
rs1039015 -- 8,562,012(+) ATCTC(A/G)GTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYH10 Gene

Variant ID Type Subtype PubMed ID
dgv1414n106 CNV deletion 24896259
dgv174e215 CNV deletion 23714750
esv1105639 CNV deletion 17803354
esv2112361 CNV deletion 18987734
esv2715614 CNV deletion 23290073
esv2715615 CNV deletion 23290073
esv2715616 CNV deletion 23290073
nsv1071332 CNV deletion 25765185
nsv111760 CNV deletion 16902084
nsv111869 CNV deletion 16902084
nsv1127535 CNV deletion 24896259
nsv471981 CNV novel sequence insertion 20440878
nsv478579 CNV novel sequence insertion 20440878
nsv510433 OTHER sequence alteration 20534489
nsv510434 OTHER sequence alteration 20534489
nsv960404 CNV duplication 23825009

Variation tolerance for MYH10 Gene

Residual Variation Intolerance Score: 0.373% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYH10 Gene

Human Gene Mutation Database (HGMD)
MYH10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYH10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYH10 Gene

Disorders for MYH10 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MYH10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
may-hegglin anomaly
  • dohle leukocyte inclusions with giant platelets
lymphangioleiomyomatosis
  • lymphangioleiomyomatosis, somatic
gitelman syndrome
  • hypomagnesemia-hypokalemia, primary renotubular, with hypocalciuria
infantile myofibromatosis
  • myofibromatosis
- elite association - COSMIC cancer census association via MalaCards
Search MYH10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYH10

Genetic Association Database (GAD)
MYH10
Human Genome Epidemiology (HuGE) Navigator
MYH10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYH10
genes like me logo Genes that share disorders with MYH10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYH10 Gene

Publications for MYH10 Gene

  1. Cloning of the cDNA encoding human nonmuscle myosin heavy chain-B and analysis of human tissues with isoform-specific antibodies. (PMID: 7499478) Phillips C.L. … Adelstein R.S. (J. Muscle Res. Cell Motil. 1995) 3 4 22 64
  2. Neuronal cell expression of inserted isoforms of vertebrate nonmuscle myosin heavy chain II-B. (PMID: 7782316) Itoh K. … Adelstein R.S. (J. Biol. Chem. 1995) 3 4 22 64
  3. Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes. (PMID: 1860190) Simons M. … Weir L. (Circ. Res. 1991) 2 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64

Products for MYH10 Gene

Sources for MYH10 Gene

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