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GIFtS

MYH1 Gene

protein-coding   GIFtS: 59
GCID: GC17M010395

myosin, heavy chain 1, skeletal muscle, adult

(Previous names: myosin, heavy polypeptide 1, skeletal muscle, adult )
 Explore 15 diseases affiliated with
MYH1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MYH1    

Aliases
for MYH1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Myosin, Heavy Chain 1, Skeletal Muscle, Adult1 2     Myosin Heavy Chain IIx/D2 3
MYHSA11 2     Myosin Heavy Chain, Skeletal Muscle, Adult 12 3
MYHa1 2     MyHC-2x2 3
MyHC-2X/D1 2     MGC1333841
Myosin, Heavy Polypeptide 1, Skeletal Muscle, Adult1 2     MyHC-IIx/D1
Myosin Heavy Chain 12 3     Myosin-11
Myosin Heavy Chain 2x2 3     MyHC-IIx/D1

External Ids:    HGNC: 75671   Entrez Gene: 46192   Ensembl: ENSG000001090617   OMIM: 1607305   UniProtKB: P128823   

Export aliases for MYH1 gene to outside databases

Previous GC identifers: GC17U990062 GC17M011510 GC17M010338 GC17M010596 GC17M010336


Summaries
for MYH1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MYH1:
Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of
ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light
chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain
(MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is
spatially and temporally regulated during development. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MYH1_HUMAN, P12882
Function: Muscle contraction

summary for MYH1:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYH1


Genomic Views
for MYH1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYH1 gene promoter:
         E2F-4   E2F-3a   E2F-5   Nkx2-5   E2F-2   GATA-2   E2F   E2F-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MYH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MYH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17pter-p11

MYH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYH1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M010395:  view genomic region     (about GC identifiers)

Start:
 10,395,624 bp from pter      End:
 10,421,860 bp from pter
Size:
 26,237 bases      Orientation:
 minus strand

Proteins
for MYH1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MYH1_HUMAN, P12882 (See protein sequence)
Recommended Name: Myosin-1  
Size: 1939 amino acids; 223145 Da
Subunit: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain
subunits (MLC) and 2 regulatory light chain subunits (MLC-2)
Subcellular location: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils
Caution: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1)
Secondary accessions: Q14CA4 Q9Y622

Explore the universe of human proteins at neXtProt for MYH1: NX_P12882

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P12882

    • MYH1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005954.3  
    ENSEMBL proteins: 
     ENSP00000226207  

    Human Recombinant Protein Products: 
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    Uscn Proteins for MYH1

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005859muscle myosin complex IDA18310078
    GO:0005925focal adhesion IDA--
    GO:0014704intercalated disc IEA--


    MYH1 for ontologies           About GeneDecksing



    MYH1 Antibody Products: 
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    Novus Biologicals MYH1 Antibodies
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    Uscn Antibodies for MYH1
    ThermoFisher Antibodies for MYH1

    Assay Products for MYH1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript Custom Assay Services for MYH1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MYH1

    Protein Domains /
    Families
    for MYH1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MYH1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR004009 Myosin_N
     IPR000048 IQ_motif_EF-hand-BS
     IPR002928 Myosin_tail
     IPR015650 Myosin_1/23/4/7/8/13/15
     IPR001609 Myosin_head_motor_dom

    Graphical View of Domain Structure for InterPro Entry P12882

    ProtoNet protein and cluster: P12882

    3 Blocks protein families:
    IPB000048 IQ calmodulin-binding region
    IPB002928 Myosin tail
    IPB004009 Myosin N-terminal SH3-like domain


    UniProtKB/Swiss-Prot: MYH1_HUMAN, P12882
    Domain: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4
    heptapeptides, characteristic for alpha-helical coiled coils
    Domain: Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later
    be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2)
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 myosin head-like domain


    Function
    for MYH1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MYH1_HUMAN, P12882
    Function: Muscle contraction

         Genatlas biochemistry entry for MYH1:
    myosin,motor contractile protein moving towards the "plus" end of actin track,heavy polypeptide 1,skeletal muscle,adult

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MYH1
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYH1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate MYH1:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-2113
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYH1 (see all 4)
    OriGene shRNA RFP: MYH1
    OriGene siRNA: MYH1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MYH1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MYH1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MYH1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MYH1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYH1 

    Cell Line
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    Search LifeMap BioReagents cell lines for MYH1

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
    GO:0003779actin binding IEA--
    GO:0005516calmodulin binding IEA--
    GO:0005524ATP binding IEA--


    MYH1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Myh1tm1Lnwd for MYH1
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Myh1):
     behavior/neurological  growth/size  muscle  skeleton 

    MYH1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MYH1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_Integrin-mediated cell adhesion and migration
    		Cell adhesion_Integrin-mediated cell adhesion and migration1.00
    		Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    		Cell adhesion Integrin-mediated cell adhesion and migration1.00
    		Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases0.49
    2Immune response _CCR3 signaling in eosinophils
    		Immune response _CCR3 signaling in eosinophils1.00
    		Inhibitory action of Lipoxins on neutrophil migration0.51
    		Immune response CCR3 signaling in eosinophils1.00
    3PAK Pathway
    		PAK Pathway1.00
    		Epithelial Adherens Junctions0.36
    		Antioxidant Action of Vitamin-C0.56
    4Cell adhesion Tight junctions
    		Cell adhesion Tight junctions1.00
    		Cell adhesion_Tight junctions0.99
    5Development MAG-dependent inhibition of neurite outgrowth
    		Development MAG-dependent inhibition of neurite outgrowth1.00
    		Development_MAG-dependent inhibition of neurite outgrowth0.87

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 EMD Millipore Pathways for MYH1
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils
    Development MAG-dependent inhibition of neurite outgrowth

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MYH1 (see all 11)
        RhoA Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions

    5/6 GeneGo (Thomson Reuters) Pathways for MYH1 (see all 6)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils
    Cell adhesion Tight junctions


    2         Kegg Pathways  (Kegg details for MYH1):
        Tight junction
    Viral myocarditis


    MYH1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for MYH1 (P128823 ENSP000002262074) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTR3BQ9P1U13, ENSP000002560014I2D: score=1 STRING: ENSP00000256001
    BAZ1BQ9UIG03, ENSP000003424344I2D: score=1 STRING: ENSP00000342434
    STAU1O957933, ENSP000003609224I2D: score=3 STRING: ENSP00000360922
    EXT1Q163943, ENSP000003674464I2D: score=1 STRING: ENSP00000367446
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Drugs & Compounds
    for MYH1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MYH1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MYH1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (R)-(+)-BlebbistatinSelective inhibitor of myosin II. Inactive enantiomer of (±)-blebbistatin (Cat. No. 1760)--
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II. Active enantiomer of (±)-blebbistatin (Cat. No. 1760)[856925-71-8]
    (±)-BlebbistatinSelective inhibitor of myosin II[674289-55-5]
    1 Novoseek chemical compound relationship for MYH1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 8.67 2 16889886 (1), 8898008 (1)

    Search CenterWatch for drugs/clinical trials and news about MYH1 

    Transcripts
    for MYH1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MYH1 gene: 
    NM_005963.3  

    Unigene Cluster for MYH1:

    Myosin, heavy chain 1, skeletal muscle, adult
    Hs.689619  [show with all ESTs]
    Unigene Representative Sequence: NM_005963
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000226207(uc002gmo.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MYH1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate MYH1:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-2113
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MYH1 (see all 4)
    OriGene shRNA RFP: MYH1
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    Clone
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    Additional cDNA sequence: 

    AF111785.1 AK310004.1 BC022376.2 BC114545.1 X03740.1 

    14 DOTS entries:

    DT.95333920  DT.121011605  DT.450952  DT.100020750  DT.92452448  DT.92452462  DT.121011611  DT.409212 
    DT.121011650  DT.91911734  DT.92452465  DT.95069216  DT.121011618  DT.95134937 

    24/360 AceView cDNA sequences (see all 360):

    AA192637 F29771 F18911 F27373 AJ573934 F28725 CF552204 CF553036 
    AA214068 F29611 F24623 F22765 F32013 F36197 AA192839 F26983 
    F17405 BM716583 F21722 F23374 F36130 CF552962 F25925 AA180982 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MYH1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b
    SP1:                                                                                                                                    
    SP2:                                                                                                                                    
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for MYH1

    Expression
    for MYH1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MYH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAGAAAAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MYH1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/19 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 19) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMultinuclear MyocytesSkeletal Muscle
    LimbForelimb Dorsal MusclesMultinuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMultinuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMultinuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleAnterior Neck MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleCervical Back MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleLumbar Back MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleLumbar Vertebrae Column MusclesMultinuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Myotubes (Generation of skelet...)
    Expanded PAX7 cells (Generation of skelet...)
    Skeletal myocytes (Generation of skelet...)

    See MYH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MYH1

    SOURCE GeneReport for Unigene cluster: Hs.689619
        SABiosciences Expression via Pathway-Focused PCR Arrays including MYH1: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MYH1
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MYH1

    Orthologs
    for MYH1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MYH1 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MYH11 myosin, heavy chain 1, skeletal muscle, adult 84.61(n)
    91.9(a)    		   417309  NM_001013396.1  NP_001013414.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 89(a)
    		 1 → many
    		 2(109026006-109052169)
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01102039.16
    		 --
    		 42(a)
    		 possible ortholog
    		 12(67545-75100)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Mhc3 striated muscle contraction myosin ATPase 50(a)
    (best of 2)    		   2 36B1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea F58G4.13 myosin 48(a)
    (best of 6)    		   V(8111649-8120439)   --


    ENSEMBL Gene Tree for MYH1 (if available)
    TreeFam Gene Tree for MYH1 (if available) 

    Paralogs
    for MYH1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MYH1 gene
    MYH82  MYH22  MYH112  MYH142  MYH92  MYH132  MYH102  MYH7B2  
    MYH42  MYH32  MYH62  MYH152  MYH72  
    18/24 SIMAP similar genes for MYH1 using alignment to 2 protein entries:     MYH1_HUMAN (see all proteins) (see all similar genes):
    MYH8    MYH2    MYH4    MYH6    MYH7    MYH13
    MYH3    MYH7B    MYH15    MYH16    MYH11    MYH9
    MYH14    MYH10    MYO5C    MYO1C    MYO15A    MYO7B

    MYH1 for paralogs           About GeneDecksing



    Genomic Variants
    for MYH1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/625 NCBI SNPs in MYH1 are shown (see all 625)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1487252661,2
    		--10395134(+) AAAGGG/TCCAGA 1 -- ds50010--------
    rs1420410511,2
    		--10395384(+) TTTGTC/TAAGTA 1 -- ds50010--------
    rs1847488721,2
    		--10395392(+) GTAAGG/TTTTAC 1 -- ds50010--------
    rs1463455051,2
    		--10395406(+) ATATTC/GTATGT 1 -- ds50010--------
    rs1894845961,2
    		--10395414(+) TGTTTC/TATGGC 1 -- ds50010--------
    rs169434641,2
    		C,--10395500(+) TCTCTA/GTCATG 1 -- ds50013Minor allele frequency- G:0.01NA 142
    rs1508589881,2
    		C,F--10395816(+) AGCCCA/C/GTTCCT 3 R G W mis12NA EU 5873
    rs1995000541,2
    		C,--10395825(+) CTCGGC/TCTCCT 2 T A mis10--------
    rs1443691241,2
    		C,F,--10395838(+) AGCTCG/ATGCTG 2 /H syn11Minor allele frequency- A:0.00NA 4550
    rs1495727671,2
    		C,F,--10395845(+) GCTGGA/TTCCTG 2 N I mis12Minor allele frequency- T:0.00NA EU 5873

    HapMap Linkage Disequilibrium report for MYH1 (10395624 - 10421860 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MYH1: --

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    Disorders / Diseases
    for MYH1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MYH1 for disorders           About GeneDecksing

    OMIM gene information: 160730    OMIM disorders: --

    15 diseases for MYH1:    About MalaCards
    colorectal adenomatous polyposis    muscle hypertrophy    hypoadrenalism    cerebral palsy
    polyposis    hermaphroditism    spasticity    hepatocellular carcinoma
    cerebritis    gastric cancer    pharyngitis    colorectal cancer
    cholangiocarcinoma    adenoma    carcinoma

    Genetic Association Database (GAD): MYH1
    Human Genome Epidemiology (HuGE) Navigator: MYH1 (22 documents)

    Export disorders for MYH1 gene to outside databases

    Publications
    for MYH1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MYH1 gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with MYH1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. MYH Y165C and G382D mutations in hepatocellular carcinoma and cholangiocarcinoma patients. (PubMed id 16292541)1, 4 Baudhuin L.M....Highsmith W.E. (2006)
    2. Is prophylactic colectomy indicated in patients with MYH-associated polyposis? (PubMed id 15932553)1, 4 Leite J.S....Castro-Sousa F. (2005)
    3. Role of inherited defects of MYH in the development of sporadic colorectal cancer. (PubMed id 15034862)1, 4 Kambara T....Jass J.R. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity. (PubMed id 10388558)1, 2 Weiss A.... Leinwand L.A. (1999)
    6. Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle. (PubMed id 2421254)1, 2 Saez L. and Leinwand L.A. (1986)
    7. Isolation and characterization of human myosin heavy chain genes. (PubMed id 6304733)1, 3 Leinwand L.A....Nadal-Ginard B. (1983)
    8. Wearing of complete dentures reduces slow fibre and en hances hybrid fibre fraction in masseter muscle. (PubMed id 22489880)1 Cvetko E....Erzen I. (2012)
    9. Myosin heavy chain composition of the human geniogloss us muscle. (PubMed id 22337492)1 Daugherty M....Sokoloff A.J. (2012)
    10. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)

    External Searches for MYH1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing MYH1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4619 HGNC: 7567 AceView: MYH1andMYH4andMYH2 Ensembl:ENSG00000109061 euGenes: HUgn4619
    ECgene: MYH1 Kegg: 4619 H-InvDB: MYH1

    Other Databases showing MYH1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MYH1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MYH1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MYH1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MYH1 gene:
    Search GeneIP for patents involving MYH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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