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MYF6 Gene

protein-coding   GIFtS: 59
GCID: GC12P081076

Myogenic Factor 6 (Herculin)

  See MYF6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myogenic Factor 6 (Herculin)1 2     CNM32 5
Muscle-Specific Regulatory Factor 41 2 3     myf-62
Class C Basic Helix-Loop-Helix Protein 42 3     Myogenic Factor 62
MRF42 3     BHLHC43
bHLHc42 3     Myf-63

External Ids:    HGNC: 75661   Entrez Gene: 46182   Ensembl: ENSG000001110467   OMIM: 1599915   UniProtKB: P234093   

Export aliases for MYF6 gene to outside databases

Previous GC identifers: GC12P081465 GC12P079603 GC12P078158


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MYF6 Gene:
The protein encoded by this gene is a probable basic helix-loop-helix (bHLH) DNA binding protein involved in
muscle differentiation. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in
this gene are a cause of autosomal dominant centronuclear myopathy (ADCNM). (provided by RefSeq, May 2010)

GeneCards Summary for MYF6 Gene:
MYF6 (myogenic factor 6 (herculin)) is a protein-coding gene. Diseases associated with MYF6 include centronuclear myopathy 3, and centronuclear myopathy. GO annotations related to this gene include E-box binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MYF5.

UniProtKB/Swiss-Prot: MYF6_HUMAN, P23409
Function: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into
myoblasts. Probable sequence specific DNA-binding protein




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYF6 gene promoter:
         AML1a   MyoD   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYF6 promoter sequence
   Search Chromatin IP Primers for MYF6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21   Ensembl cytogenetic band:  12q21.31   HGNC cytogenetic band: 12q21

MYF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYF6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P081076:  view genomic region     (about GC identifiers)

Start:
81,101,277 bp from pter      End:
81,103,257 bp from pter
Size:
1,981 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MYF6_HUMAN, P23409 (See protein sequence)
Recommended Name: Myogenic factor 6  
Size: 242 amino acids; 26953 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein
Secondary accessions: B2R898 Q53X80 Q6FHI9

Explore the universe of human proteins at neXtProt for MYF6: NX_P23409

Explore proteomics data for MYF6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYF6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002460.1  
    ENSEMBL proteins: 
     ENSP00000228641  
    Reactome Protein details: P23409

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    2 InterPro protein domains:
     IPR002546 Basic
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry P23409

    ProtoNet protein and cluster: P23409

    2 Blocks protein domains:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB002546 Myogenic basic muscle-specific protein


    UniProtKB/Swiss-Prot: MYF6_HUMAN, P23409
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Find genes that share domains with MYF6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYF6_HUMAN, P23409
    Function: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into
    myoblasts. Probable sequence specific DNA-binding protein

         Genatlas biochemistry entry for MYF6:
    myogenic factor 6,transcription activator

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity TAS2311584
    GO:0046982protein heterodimerization activity ISS--
    GO:0046983protein dimerization activity ----
    GO:0070888contributes to E-box binding ISS--
         
    Find genes that share ontologies with MYF6           About GenesLikeMe


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Myf6):
     adipose tissue  embryogenesis  growth/size/body  homeostasis/metabolism  mortality/aging 
     muscle  no phenotypic analysis  normal  respiratory system  skeleton 
     tumorigenesis  vision/eye 

    Find genes that share phenotypes with MYF6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MYF6: Myf6tm1Eno Myf6tm1Thbr Myf6tm1Wb

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MYF6
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MYF6

    miRNA
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    miRTarBase miRNAs that target MYF6:
    hsa-mir-9-5p (MIRT021325)

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    3 qRT-PCR Assays for microRNAs that regulate MYF6:
    hsa-miR-299-5p hsa-miR-520d-5p hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidMYF6 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYF6_HUMAN, P23409: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS2311584
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with MYF6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYF6 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1CDO in myogenesis
    CDO in myogenesis1.00
    Myogenesis1.00
    2L1CAM interactions
    Developmental Biology0.63
    3Immune response Function of MEF2 in T lymphocytes
    Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis0.38
    4Id Signaling Pathway
    Id Signaling Pathway
    5Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs


    Find genes that share SuperPaths with MYF6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for MYF6
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

    3 BioSystems Pathways for MYF6
        Diurnally regulated genes with circadian orthologs
    Id Signaling Pathway
    C-MYB transcription factor network


    1 Reactome Pathway for MYF6
        CDO in myogenesis


        Pathway & Disease-focused RT2 Profiler PCR Array including MYF6: 
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MYF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYF6 (P234093 ENSP000002286414) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=6 STRING: ENSP00000349467
    CALM2P621583I2D: score=6 
    CALM3P621583I2D: score=6 
    ID3Q025353, ENSP000003636894I2D: score=3 STRING: ENSP00000363689
    CSRP3P504613, ENSP000002659684I2D: score=2 STRING: ENSP00000265968
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001756somitogenesis IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS2311584
    GO:0007517muscle organ development ----
    GO:0007519skeletal muscle tissue development TAS2311584

    Find genes that share ontologies with MYF6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYF6

    2 Novoseek inferred chemical compound relationships for MYF6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acetylcholine 37.8 5 9268324 (2), 8384125 (1), 14662021 (1), 7565669 (1)
    creatinine 22.4 8 1658626 (2), 12783039 (2), 1847137 (1), 11600695 (1) (see all 6)



    Find genes that share compounds with MYF6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYF6 gene: 
    NM_002469.2  

    Unigene Cluster for MYF6:

    Myogenic factor 6 (herculin)
    Hs.35937  [show with all ESTs]
    Unigene Representative Sequence: NM_002469
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000228641(uc001szf.2)
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate MYF6:
    hsa-miR-299-5p hsa-miR-520d-5p hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidMYF6 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat MYF6

    Additional mRNA sequence: 

    AK313287.1 BC017834.1 CR407641.1 CR541763.1 X52011.1 

    1 DOTS entry:

    DT.111894 

    Selected AceView cDNA sequences (see all 30):

    BC017834 AA228129 F24904 F36991 AA227981 CR407641 AA026188 X52011 
    BF439482 BX282108 BV198492 BV203083 AA194572 AW043717 CR541763 AI672027 
    BX501384 NM_002469 BF126314 AI190383 AA026129 AA010958 BF575142 AW243326 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYF6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MYF6 Expression
    About this image


    MYF6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 50 entries
             Myoblasts Extraocular Muscles
             Myogenic cells
     
     Somite (Muscoskeletal System)    fully expand to see all 32 entries
             Myoblasts Cervical Hypaxial Myotome
     
     Limb (Muscoskeletal System)    fully expand to see all 8 entries
             Myoblasts Forelimb Ventral Muscles
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             AII Amacrine Cells Inner Nuclear Layer
             Retina
     
     Neurons
             AII Amacrine Cells Inner Nuclear Layer
    MYF6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYF6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.35937

    UniProtKB/Swiss-Prot: MYF6_HUMAN, P23409
    Tissue specificity: Skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including MYF6: 
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MYF6 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myf61 , 5 myogenic factor 61, 5 91.6(n)1
    95.45(a)1
      10 (55.96 cM)5
    178781  NM_008657.21  NP_032683.11 
     1074928605 
    chicken
    (Gallus gallus)
    Aves MYF61 myogenic factor 6 (herculin) 80.85(n)
    85.54(a)
      417873  NM_001030746.1  NP_001025917.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYF66
    myogenic factor 6 (herculin)
    69(a)
    1 ↔ 1
    5(37036857-37046706)
    African clawed frog
    (Xenopus laevis)
    Amphibia MRF42 MRF4 [Xenopus laevis, mRNA, 942 nt] 75.03(n)    S34392.1 
    zebrafish
    (Danio rerio)
    Actinopterygii myf61 myogenic factor 6 66.81(n)
    64.81(a)
      404208  NM_001003982.1  NP_001003982.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nau6
    nautilus
    27(a)
    1 → many
    3R(19538536-19544079)
    worm
    (Caenorhabditis elegans)
    Secernentea hlh-16
    Protein HLH-1, isoform b
    24(a)
    1 → many
    II(4518560-4522457) WBGene00001948


    ENSEMBL Gene Tree for MYF6 (if available)
    TreeFam Gene Tree for MYF6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYF6 gene
    MYF52  MYOD12  MYOG2  
    3 SIMAP similar genes for MYF6 using alignment to 1 protein entry:     MYF6_HUMAN:
    MYF5    MYF4    MYOG

    Find genes that share paralogs with MYF6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYF6 (see all 88)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1382964481,2,,4
    C,FMyopathy, centronuclear, 3 (CNM3)4 --80949035(+) ATCTGC/ACCCCA 2 /D /A mis12Minor allele frequency- A:0.00NA EU 5059
    rs289289091,2,,4
    C,FMyopathy, centronuclear, 3 (CNM3)4 pathogenic180949100(+) ACGAGG/TCCTTC 2 A S mis1 ese32Minor allele frequency- T:0.00NA EU 5205
    rs1875319701,2
    --80946857(+) TTGGCC/TTCTTG 1 -- us2k10--------
    rs22477801,2
    C,F,O,A,H--80946982(+) GAAACT/CGTGAA 1 -- us2k1104Minor allele frequency- C:0.29NS EA NA PA EU CA WA CSA 6417
    rs1921082281,2
    --80946983(+) AAACTA/GTGAAG 1 -- us2k10--------
    rs1141902931,2
    C,F--80947008(+) ATAGGC/AGACTT 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1389029371,2
    C--80947064(+) TCTTCA/GCTCTA 1 -- us2k10--------
    rs1489718231,2
    --80947177(+) ACTATA/GAAGAC 1 -- us2k10--------
    rs1177572191,2
    C,F--80947262(+) TGAAAG/AGAAGG 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1845571491,2
    --80947354(+) TCTTTA/GCCCTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MYF6 (81101277 - 81103257 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MYF6: --
    Human Gene Mutation Database (HGMD): MYF6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYF6
    DNA2.0 Custom Variant and Variant Library Synthesis for MYF6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 159991   
    OMIM disorders: 614408  
    UniProtKB/Swiss-Prot: MYF6_HUMAN, P23409
  • Myopathy, centronuclear, 3 (CNM3) [MIM:614408]: A congenital muscle disorder characterized by progressive
    muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal
    muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade
    of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high
    frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of
    sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers. Note=The
    disease may be caused by mutations affecting the gene represented in this entry

  • 3 diseases for MYF6:    
    About MalaCards
    centronuclear myopathy 3    centronuclear myopathy    becker muscular dystrophy

    2 diseases from the University of Copenhagen DISEASES database for MYF6:
    Rhabdomyosarcoma     Extraosseous Ewing's sarcoma

    Find genes that share disorders with MYF6           About GenesLikeMe

    4 Novoseek inferred disease relationships for MYF6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rhabdomyosarcoma 56.9 1 1764365 (1)
    hypertrophy 33.5 2 12716875 (1), 10370140 (1)
    atrophy 8.59 2 19696363 (1), 9460713 (1)
    tumors 0 1 1717137 (1)

    Genetic Association Database (GAD): MYF6
    Human Genome Epidemiology (HuGE) Navigator: MYF6 (2 documents)

    Export disorders for MYF6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYF6 gene, integrated from 10 sources (see all 123):
    (articles sorted by number of sources associating them with MYF6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human myogenic factors 5 and 6 (MYF5, MYF6) gene cluster to 12q21 by in situ hybridization and physical mapping of the locus between D12S350 and D12S106. (PubMed id 8978788)1, 3, 9 Cupelli L....Krauter K. (Cytogenet. Cell Genet. 1996)
    2. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Heterozygous myogenic factor 6 mutation associated with myopathy and severe course of Becker muscular dystrophy. (PubMed id 11053684)1, 2 Kerst B....Huebner C. (Neuromuscul. Disord. 2000)
    5. Myf-6, a new member of the human gene family of myogenic determination factors: evidence for a gene cluster on chromosome 12. (PubMed id 2311584)1, 2 Braun T.... Arnold H.H. (EMBO J. 1990)
    6. The myogenic basic helix-loop-helix family of transcription factors shows similar requirements for SWI/SNF chromatin remodeling enzymes during muscle differentiation in culture. (PubMed id 12105204)1, 9 Roy K....Imbalzano A.N. (J. Biol. Chem. 2002)
    7. Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD. (PubMed id 9234731)1, 9 Kong Y....Konieczny S.F. (Mol. Cell. Biol. 1997)
    8. The four human muscle regulatory helix-loop-helix proteins Myf3-Myf6 exhibit similar hetero-dimerization and DNA binding properties. (PubMed id 1945842)1, 9 Braun T. and Arnold H.H. (Nucleic Acids Res. 1991)
    9. Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adults. (PubMed id 16614355)1 Kosek D.J....Bamman M.M. (J. Appl. Physiol. 2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4618 HGNC: 7566 AceView: MYF6 Ensembl:ENSG00000111046 euGenes: HUgn4618
    ECgene: MYF6 H-InvDB: MYF6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MYF6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MYF6 gene:
    Search GeneIP for patents involving MYF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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