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MYF5 Gene

protein-coding   GIFtS: 59
GCID: GC12P081085

Myogenic Factor 5

  See MYF5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myogenic Factor 51 2
Class C Basic Helix-Loop-Helix Protein 22 3
bHLHc22 3
myf-52
BHLHC23
Myf-53

External Ids:    HGNC: 75651   Entrez Gene: 46172   Ensembl: ENSG000001110497   OMIM: 1599905   UniProtKB: P133493   

Export aliases for MYF5 gene to outside databases

Previous GC identifers: GC12P081474 GC12P079613 GC12P078167


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYF5 Gene:
MYF5 (myogenic factor 5) is a protein-coding gene. Diseases associated with MYF5 include cerebro-costo-mandibular syndrome. GO annotations related to this gene include E-box binding and protein heterodimerization activity. An important paralog of this gene is MYOD1.

UniProtKB/Swiss-Prot: MYF5_HUMAN, P13349
Function: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and
plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter
core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific
DNA-binding protein




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYF5 gene promoter:
         AML1a   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYF5 promoter sequence
   Search Chromatin IP Primers for MYF5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21   Ensembl cytogenetic band:  12q21.31   HGNC cytogenetic band: 12q21

MYF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYF5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P081085:  view genomic region     (about GC identifiers)

Start:
81,110,691 bp from pter      End:
81,113,452 bp from pter
Size:
2,762 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MYF5_HUMAN, P13349 (See protein sequence)
Recommended Name: Myogenic factor 5  
Size: 255 amino acids; 28296 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein
Secondary accessions: Q6ISR9

Explore the universe of human proteins at neXtProt for MYF5: NX_P13349

Explore proteomics data for MYF5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MYF5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005584.2  
    ENSEMBL proteins: 
     ENSP00000228644  
    Reactome Protein details: P13349

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    antibodies-online proteins for MYF5 (4 products) 

     
    antibodies-online peptides for MYF5

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    antibodies-online antibodies for MYF5 (78 products) 

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    Cloud-Clone Corp. ELISAs for MYF5
    Cloud-Clone Corp. CLIAs for MYF5
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    antibodies-online kits for MYF5 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    3 InterPro protein domains:
     IPR022032 Myf5
     IPR002546 Basic
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry P13349

    ProtoNet protein and cluster: P13349

    2 Blocks protein domains:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB002546 Myogenic basic muscle-specific protein


    UniProtKB/Swiss-Prot: MYF5_HUMAN, P13349
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Find genes that share domains with MYF5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYF5_HUMAN, P13349
    Function: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and
    plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter
    core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific
    DNA-binding protein

         Genatlas biochemistry entry for MYF5:
    myogenic factor 5,transcription activator

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity TAS2311584
    GO:0005515protein binding IPI19829708
    GO:0046982protein heterodimerization activity ISS--
    GO:0046983protein dimerization activity ----
         
    Find genes that share ontologies with MYF5           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 17 alleles(MGI details for Myf5) (see all 16):
     adipose tissue  behavior/neurological  cellular  embryogenesis  growth/size/body 
     homeostasis/metabolism  immune system  mortality/aging  muscle  nervous system 
     no phenotypic analysis  normal  respiratory system  skeleton  tumorigenesis 

    Find genes that share phenotypes with MYF5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MYF5: Myf5tm1Tajb Myf5tm3.1Thbr Myf5tm2Tajb Myf5tm1Jae

       genOway: Develop your customized and physiologically relevant rodent model for MYF5

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  BAACAGCTGT 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MYF5:
    hsa-mir-148b-3p (MIRT019252)

    Block miRNA regulation of human, mouse, rat MYF5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MYF5 (see all 13):
    hsa-miR-142-5p hsa-miR-34b* hsa-miR-4311 hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidMYF5 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MYF5
    Predesigned siRNA for gene silencing in human, mouse, rat MYF5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MYF5

    Clone
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    OriGene clones in human, mouse for MYF5 (see all 7)
    OriGene ORF clones in mouse, rat for MYF5
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    GenScript: all cDNA clones in your preferred vector: MYF5 (NM_005593)
    Sino Biological Human cDNA Clone for MYF5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MYF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MYF5

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYF5

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-11144) for MYF5 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MYF5_HUMAN, P13349: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton3
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with MYF5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MYF5 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1CDO in myogenesis
    CDO in myogenesis1.00
    Myogenesis1.00
    2L1CAM interactions
    Developmental Biology0.63
    3Transcriptional Regulatory Network in Embryonic Stem Cell
    Transcriptional Regulatory Network in Embryonic Stem Cell
    4Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    5miRs in Muscle Cell Differentiation
    miRs in Muscle Cell Differentiation


    Find genes that share SuperPaths with MYF5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MYF5
        Transcriptional Regulatory Network in Embryonic Stem Cell

    3 BioSystems Pathways for MYF5
        Id Signaling Pathway
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    miRs in Muscle Cell Differentiation


    1 Reactome Pathway for MYF5
        CDO in myogenesis


        Pathway & Disease-focused RT2 Profiler PCR Arrays including MYF5: 
              Notch Signaling Targets in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Transcription Factors in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MYF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MYF5 (P133493 ENSP000002286444) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=3 STRING: ENSP00000349467
    CALM2P621583I2D: score=3 
    CALM3P621583I2D: score=3 
    ID3Q025353, ENSP000003636894I2D: score=2 STRING: ENSP00000363689
    TCF3P159233, ENSP000002629654I2D: score=2 STRING: ENSP00000262965
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001502cartilage condensation IEA--
    GO:0001503ossification IEA--
    GO:0001756somitogenesis IEA--
    GO:0001952regulation of cell-matrix adhesion IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    Find genes that share ontologies with MYF5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MYF5

    7 Novoseek inferred chemical compound relationships for MYF5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatinine 30.7 7 1847137 (1), 1337140 (1), 18156397 (1), 1717137 (1) (see all 5)
    retinoic acid 12 3 19757389 (1), 8194491 (1), 15674337 (1)
    acetylcholine 3.51 5 8384125 (1), 14662021 (1), 7565669 (1)
    calcium 0 3 11148132 (2)
    bromodeoxyuridine 0 2 11374435 (1)
    glutamate 0 1 9461343 (1)
    serine 0 2 11073992 (1), 9461343 (1)



    Find genes that share compounds with MYF5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MYF5 gene: 
    NM_005593.2  

    Unigene Cluster for MYF5:

    Myogenic factor 5
    Hs.178023  [show with all ESTs]
    Unigene Representative Sequence: NM_005593
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000228644(uc001szg.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MYF5 (see all 13):
    hsa-miR-142-5p hsa-miR-34b* hsa-miR-4311 hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidMYF5 3' UTR sequence
    Inhib. RNA
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    Primer
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    Flow Cytometry
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    Additional mRNA sequence: 

    BC069373.1 BT019399.1 X14894.1 

    1 DOTS entry:

    DT.107594 

    8 AceView cDNA sequences:

    BX089431 AA411605 X14894 AA422092 BC069373 NM_005593 CA335375 CB856775 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MYF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACATAAAGA
    MYF5 Expression
    About this image


    MYF5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 72 entries
             Multinuclear Myocyte Extraocular Muscles
             Myogenic cells
             gastrocnemius muscle   
     
     Somite (Muscoskeletal System)    fully expand to see all 42 entries
             Myoblasts Cervical Hypaxial Myotome
             mesenchyme/trunk mesenchyme/paraxial mesenchyme   
     
     Limb (Muscoskeletal System)    fully expand to see all 8 entries
             Myoblasts Forelimb Ventral Muscles
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 3 entries
             Muscle Progenitor Cells Hypobranchial Muscles
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Mesoderm-like cells
    MYF5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MYF5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.178023
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MYF5: 
              Notch Signaling Targets in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Transcription Factors in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat MYF5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYF5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MYF5 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Myf51 , 5 myogenic factor 51, 5 86.67(n)1
    89.41(a)1
      10 (55.95 cM)5
    178771  NM_008656.51  NP_032682.11 
     1074829085 
    chicken
    (Gallus gallus)
    Aves MYF51 myogenic factor 5 72.55(n)
    71.76(a)
      395633  NM_001030363.1  NP_001025534.1 
    lizard
    (Anolis carolinensis)
    Reptilia MYF56
    myogenic factor 5
    55(a)
    1 ↔ 1
    5(37007816-37018637)
    African clawed frog
    (Xenopus laevis)
    Amphibia XMyf-52 myogenic factor Xmyf-5 74.81(n)    X56738.1 
    zebrafish
    (Danio rerio)
    Actinopterygii myf52 myogenic factor 5 75.18(n)   58097  AF270789.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nau6
    nautilus
    30(a)
    1 → many
    3R(19538536-19544079)
    worm
    (Caenorhabditis elegans)
    Secernentea hlh-16
    Protein HLH-1, isoform b
    22(a)
    1 → many
    II(4518560-4522457) WBGene00001948


    ENSEMBL Gene Tree for MYF5 (if available)
    TreeFam Gene Tree for MYF5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MYF5 gene
    MYOD12  MYOG2  MYF62  
    4 SIMAP similar genes for MYF5 using alignment to 1 protein entry:     MYF5_HUMAN:
    MYF6    MYOD1    MYF4    MYOG

    Find genes that share paralogs with MYF5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MYF5 (see all 131)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1473700131,2
    C--81108744(+) AGGTAA/GCAATG 1 -- us2k10--------
    rs1879473941,2
    --81108763(+) ATTTGC/TTGTGC 1 -- us2k10--------
    rs1390589211,2
    --81108881(+) AGGCAC/TAGACT 1 -- us2k10--------
    rs787476441,2
    F--81108930(+) CTGGTC/TAGATG 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1913085831,2
    --81109047(+) CCTTAA/GTGACT 1 -- us2k10--------
    rs177166661,2
    C,F--81109075(+) ACCTCT/CGGTTT 1 -- us2k16Minor allele frequency- C:0.14NA EA 358
    rs170072071,2
    C,F,H--81109151(+) GCTGGA/GTCAAT 1 -- us2k18Minor allele frequency- G:0.05NA NS EA WA 674
    rs1498727081,2
    --81109160(+) ATGAAA/CCAGTG 1 -- us2k10--------
    rs11632591,2
    C,F,H--81109181(+) AAAATA/GATTCT 1 -- us2k1 tfbs311Minor allele frequency- G:0.03MN EA NA NS WA 766
    rs1140611091,2
    F--81109205(+) AAAGTA/TCCATT 1 -- us2k11Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for MYF5 (81110691 - 81113452 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MYF5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MYF5
    DNA2.0 Custom Variant and Variant Library Synthesis for MYF5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 159990    OMIM disorders: --

    1 disease for MYF5:    
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    cerebro-costo-mandibular syndrome

    2 diseases from the University of Copenhagen DISEASES database for MYF5:
    Myopathy     Rhabdomyosarcoma

    Find genes that share disorders with MYF5           About GenesLikeMe

    4 Novoseek inferred disease relationships for MYF5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rhabdomyosarcoma 47.9 2 19299559 (1), 12944914 (1)
    myotonic dystrophy 16.5 1 7969178 (1)
    atrophy 14.6 3 19696363 (1), 9460713 (1)
    tumors 0 1 12640103 (1)

    Genetic Association Database (GAD): MYF5
    Human Genome Epidemiology (HuGE) Navigator: MYF5 (2 documents)

    Export disorders for MYF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MYF5 gene, integrated from 10 sources (see all 221):
    (articles sorted by number of sources associating them with MYF5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The myogenic basic helix-loop-helix family of transcription factors shows similar requirements for SWI/SNF chromatin remodeling enzymes during muscle differentiation in culture. (PubMed id 12105204)1, 3, 9 Roy K....Imbalzano A.N. (J. Biol. Chem. 2002)
    2. Assignment of the human myogenic factors 5 and 6 (MYF5, MYF6) gene cluster to 12q21 by in situ hybridization and physical mapping of the locus between D12S350 and D12S106. (PubMed id 8978788)1, 3, 9 Cupelli L....Krauter K. (Cytogenet. Cell Genet. 1996)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    4. A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts. (PubMed id 2721498)1, 2 Braun T.... Arnold H.H. (EMBO J. 1989)
    5. Two putative protein kinase CK2 phosphorylation sites are important for Myf-5 activity. (PubMed id 9461343)1, 9 Winter B....Arnold H.H. (Biol. Chem. 1997)
    6. Transcriptional activation domain of the muscle-specific gene-regulatory protein myf5. (PubMed id 2385294)1, 9 Braun T....Arnold H.H. (Nature 1990)
    7. DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation. (PubMed id 19829708)1, 9 Ansseau E.... Coppee F. (PLoS ONE 2009)
    8. Efficient in vitro myogenic reprogramming of human primary mesenchymal stem cells and endothelial cells by Myf5. (PubMed id 21810080)1 Dimicoli-Salazar S....Vigon I. (Biol. Cell 2011)
    9. Altered binding of MYF-5 to FOXE1 promoter in non-syndromic and CHARGE-associated cleft palate. (PubMed id 19192046)1 Venza M....Teti D. (amp 2009)
    10. Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adults. (PubMed id 16614355)1 Kosek D.J....Bamman M.M. (J. Appl. Physiol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4617 HGNC: 7565 AceView: MYF5 Ensembl:ENSG00000111049 euGenes: HUgn4617
    ECgene: MYF5 H-InvDB: MYF5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MYF5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MYF5 gene:
    Search GeneIP for patents involving MYF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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