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Aliases for MYF5 Gene

Aliases for MYF5 Gene

  • Myogenic Factor 5 2 3
  • Class C Basic Helix-Loop-Helix Protein 2 3 4
  • BHLHc2 3 4
  • Myf-5 3 4

External Ids for MYF5 Gene

Previous GeneCards Identifiers for MYF5 Gene

  • GC12P081085
  • GC12P081474
  • GC12P079613
  • GC12P078167

Summaries for MYF5 Gene

GeneCards Summary for MYF5 Gene

MYF5 (Myogenic Factor 5) is a Protein Coding gene. Diseases associated with MYF5 include cerebro-costo-mandibular syndrome. Among its related pathways are L1CAM interactions and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. GO annotations related to this gene include protein heterodimerization activity and E-box binding. An important paralog of this gene is MYOD1.

UniProtKB/Swiss-Prot for MYF5 Gene

  • Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYF5 Gene

Genomics for MYF5 Gene

Regulatory Elements for MYF5 Gene

Transcription factor binding sites by QIAGEN in the MYF5 gene promoter:

Genomic Location for MYF5 Gene

Start:
80,716,912 bp from pter
End:
80,719,673 bp from pter
Size:
2,762 bases
Orientation:
Plus strand

Genomic View for MYF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYF5 Gene

Proteins for MYF5 Gene

  • Protein details for MYF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13349-MYF5_HUMAN
    Recommended name:
    Myogenic factor 5
    Protein Accession:
    P13349
    Secondary Accessions:
    • Q6ISR9

    Protein attributes for MYF5 Gene

    Size:
    255 amino acids
    Molecular mass:
    28296 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein

neXtProt entry for MYF5 Gene

Proteomics data for MYF5 Gene at MOPED

Post-translational modifications for MYF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYF5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MYF5 Gene

Domains for MYF5 Gene

Gene Families for MYF5 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Suggested Antigen Peptide Sequences for MYF5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13349

UniProtKB/Swiss-Prot:

MYF5_HUMAN :
  • P13349
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with MYF5: view

Function for MYF5 Gene

Molecular function for MYF5 Gene

GENATLAS Biochemistry: myogenic factor 5,transcription activator
UniProtKB/Swiss-Prot Function: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein

Gene Ontology (GO) - Molecular Function for MYF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IBA --
GO:0003677 DNA binding --
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity TAS 2311584
GO:0005515 protein binding IPI 19829708
genes like me logo Genes that share ontologies with MYF5: view
genes like me logo Genes that share phenotypes with MYF5: view

Animal Models for MYF5 Gene

MGI Knock Outs for MYF5:

miRNA for MYF5 Gene

miRTarBase miRNAs that target MYF5
Targeting motifs for MYF5 Gene
HOMER Transcription Factor Regulatory Elements motif MYF5
  • Consensus sequence: BAACAGCTGT Submotif: canonical Cell Type: GM GeoId: GSE24852

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for MYF5 Gene

Localization for MYF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYF5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYF5 Gene COMPARTMENTS Subcellular localization image for MYF5 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
extracellular 1

Gene Ontology (GO) - Cellular Components for MYF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0090575 RNA polymerase II transcription factor complex ISS 8035824
genes like me logo Genes that share ontologies with MYF5: view

Pathways for MYF5 Gene

genes like me logo Genes that share pathways with MYF5: view

Gene Ontology (GO) - Biological Process for MYF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001502 cartilage condensation IEA --
GO:0001503 ossification IEA --
GO:0001756 somitogenesis IEA --
GO:0001952 regulation of cell-matrix adhesion IEA --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with MYF5: view

Compounds for MYF5 Gene

(7) Novoseek inferred chemical compound relationships for MYF5 Gene

Compound -log(P) Hits PubMed IDs
creatinine 30.7 5
retinoic acid 12 3
acetylcholine 3.51 3
calcium 0 2
bromodeoxyuridine 0 1
genes like me logo Genes that share compounds with MYF5: view

Transcripts for MYF5 Gene

mRNA/cDNA for MYF5 Gene

(8) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYF5 Gene

Myogenic factor 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYF5 Gene

No ASD Table

Relevant External Links for MYF5 Gene

GeneLoc Exon Structure for
MYF5
ECgene alternative splicing isoforms for
MYF5

Expression for MYF5 Gene

mRNA expression in normal human tissues for MYF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYF5 Gene

This gene is overexpressed in Muscle - Skeletal (50.0).

SOURCE GeneReport for Unigene cluster for MYF5 Gene Hs.178023

genes like me logo Genes that share expressions with MYF5: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for MYF5 Gene

Orthologs for MYF5 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYF5 35
  • 98.95 (n)
  • 100 (a)
MYF5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYF5 35
  • 91.37 (n)
  • 94.51 (a)
MYF5 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYF5 35
  • 87.19 (n)
  • 87.84 (a)
MYF5 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myf5 35
  • 86.67 (n)
  • 89.41 (a)
Myf5 16
Myf5 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYF5 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYF5 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myf5 35
  • 86.8 (n)
  • 89.8 (a)
chicken
(Gallus gallus)
Aves MYF5 35
  • 72.55 (n)
  • 71.76 (a)
MYF5 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYF5 36
  • 55 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia XMyf-5 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76020 35
myf5 35
  • 67.19 (n)
  • 71.37 (a)
zebrafish
(Danio rerio)
Actinopterygii myf5 35
  • 65.25 (n)
  • 61.86 (a)
myf5 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nau 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hlh-1 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
OneToMany
Species with no ortholog for MYF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYF5 Gene

ENSEMBL:
Gene Tree for MYF5 (if available)
TreeFam:
Gene Tree for MYF5 (if available)

Paralogs for MYF5 Gene

Paralogs for MYF5 Gene

Selected SIMAP similar genes for MYF5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MYF5: view

Variants for MYF5 Gene

Sequence variations from dbSNP and Humsavar for MYF5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1163259 -- 80,715,402(+) AAAAT(A/G)ATTCT upstream-variant-2KB
rs1163260 -- 80,716,448(+) ATTGC(C/T)GGAAA upstream-variant-2KB
rs1163261 -- 80,716,986(+) TGCCC(A/G)TCGGC utr-variant-5-prime
rs1163262 -- 80,718,523(+) TTGGG(A/G)AAGGG intron-variant
rs1163263 -- 80,720,051(+) GTTAA(A/G)TCATA downstream-variant-500B

Relevant External Links for MYF5 Gene

HapMap Linkage Disequilibrium report
MYF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MYF5 Gene

Disorders for MYF5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MYF5 Gene including...

Search for MYF5 Gene in MalaCards »

(2) University of Copenhagen DISEASES for MYF5 Gene

(4) Novoseek inferred disease relationships for MYF5 Gene

Disease -log(P) Hits PubMed IDs
rhabdomyosarcoma 47.9 2
myotonic dystrophy 16.5 1
atrophy 14.6 2
tumors 0 1

Relevant External Links for MYF5

Genetic Association Database (GAD)
MYF5
Human Genome Epidemiology (HuGE) Navigator
MYF5
genes like me logo Genes that share disorders with MYF5: view

No data available for UniProtKB/Swiss-Prot for MYF5 Gene

Publications for MYF5 Gene

  1. The myogenic basic helix-loop-helix family of transcription factors shows similar requirements for SWI/SNF chromatin remodeling enzymes during muscle differentiation in culture. (PMID: 12105204) Roy K. … Imbalzano A.N. (J. Biol. Chem. 2002) 2 3 23
  2. Assignment of the human myogenic factors 5 and 6 (MYF5, MYF6) gene cluster to 12q21 by in situ hybridization and physical mapping of the locus between D12S350 and D12S106. (PMID: 8978788) Cupelli L. … Krauter K. (Cytogenet. Cell Genet. 1996) 2 3 23
  3. A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts. (PMID: 2721498) Braun T. … Arnold H.H. (EMBO J. 1989) 3 4
  4. DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation. (PMID: 19829708) Ansseau E. … Coppee F. (PLoS ONE 2009) 3 23
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 48

Products for MYF5 Gene

Sources for MYF5 Gene

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