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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MYEOV2 Gene

protein-coding GIFtS: 43
GCID: GC02M241065

myeloma overexpressed 2

Explore 1 disease affiliated with
MYEOV2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Myeloma Overexpressed 2¹ ²
Helicase/Primase Complex Protein²
Myeloma-Overexpressed Gene 2 Protein²

External Ids:	HGNC: 21314¹	Entrez Gene: 150678²	Ensembl: ENSG00000172428⁷	UniProtKB: Q8WXC6³

Export aliases for MYEOV2 gene to outside databases

Previous GC identifers: GC02M240786 GC02M232823

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005416.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MYEOV2 gene promoter:
PPAR-gamma1 Lmo2 Hand1 AP-4 PPAR-gamma2 ATF E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MYEOV2 promoter sequence

Search SABiosciences Chromatin IP Primers for MYEOV2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MYEOV2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3 Ensembl cytogenetic band: 2q37.3 HGNC cytogenetic band: 2q37.3

MYEOV2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYEOV2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M241065: view genomic region (about GC identifiers)

Start:	241,065,980 bp from pter	End:	241,076,224 bp from pter
Size:	10,245 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MYOV2_HUMAN, Q8WXC6 (See protein sequence)

Recommended Name: Myeloma-overexpressed gene 2 protein

Size: 57 amino acids; 6211 Da

Secondary accessions: Q8N110

Alternative splicing: 2 isoforms: Q8WXC6-2 Q8WXC6-1 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MYEOV2: NX_Q8WXC6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8WXC6

MYEOV2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001156896.1 NP_612209.1

ENSEMBL proteins:

ENSP00000304147 ENSP00000383946

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8WXC6

UniProtKB/Swiss-Prot: MYOV2_HUMAN, Q8WXC6

Similarity: Belongs to the MYEOV2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MYEOV2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for MYEOV2 (Q8WXC6³ ENSP00000304147⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COPS6	Q7L5N1³, ENSP00000304102⁴	I2D: score=2 STRING: ENSP00000304102

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about MYEOV2 / MYOV2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MYEOV2 gene (2 alternative transcripts):

NM_001163424.1 NM_138336.1

Unigene Cluster for MYEOV2:

Myeloma overexpressed 2

Hs.293884 [show with all ESTs]

Unigene Representative Sequence: AK126809

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000307266(uc002vyu.1) ENST00000403160(uc010zof.1) ENST00000491765

ENST00000489698

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Additional cDNA sequence:

AF453951.1 AF487338.1 AK126809.1 BC033955.2

5 DOTS entries:

DT.444819 DT.100786524 DT.97785314 DT.97842239 DT.97842241

24/122 AceView cDNA sequences (see all 122):

BM768333 AI872187 AI347461 BI754824 BQ025380 F28544 AW207312 BQ023707

AW963401 AJ708690 AW163088 NM_138336 BE876673 BM451552 AI891108 CB069641

AI373698 AF453951 AA371861 AW163689 AK126809 AI650587 BG319561 F36625

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for MYEOV2 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5	^	6
SP1:							-						-
SP2:					-		-
SP3:

ECgene alternative splicing isoforms for MYEOV2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MYEOV2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGACTTTTT

About this image

MYEOV2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Ventral Foregut Endoderm

Gut Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MYEOV2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MYEOV2

SOURCE GeneReport for Unigene cluster: Hs.293884

SABiosciences Custom PCR Arrays for MYEOV2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MYEOV2 gene from 5/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Myeov2^{1 , 5}	myeloma overexpressed 2^{1, 5}	90.48(n)¹ 98.21(a)¹		1 (46.55 cM)⁵ 66915¹ NM_001163425.1¹ NP_001156897.1¹ 92637145⁵
chicken (Gallus gallus)	Aves	MYEOV2¹	myeloma overexpressed 2	86.9(n) 100(a)		770635 XM_001233101.1 XP_001233102.1
lizard (Anolis carolinensis)	Reptilia	MYEOV2⁶	--	95(a)	1 ↔ 1	3(28758921-28762081)
zebrafish (Danio rerio)	Actinopterygii	zgc77808²	hypothetical protein MGC77808	80(n)		393820 BC062283.1
fruit fly (Drosophila melanogaster)	Insecta	CG17059⁶	--	52(a)	1 ↔ 1	2R(9107788-9108520)

ENSEMBL Gene Tree for MYEOV2 (if available)
TreeFam Gene Tree for MYEOV2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MYEOV2 gene

MYEOV2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for MYEOV2
PGOHUM00000247802

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7605040^1,2	C,A	--	241065548(+)	`CTTTGC/GGAAAT`	1	--	ds500¹		0	--	--	--	--
rs181741568^1,2		--	241065585(+)	`CAGGGA/CTCCTT`	1	--	ds500¹		0	--	--	--	--
rs76429622^1,2	C	--	241065709(+)	`GTGTGT/CGGCCA`	1	--	ds500¹		2		NA EA	122
rs114743378^1,2	F	--	241065747(+)	`ACTCCG/ATGATA`	1	--	ds500¹		1		WA	118
rs138575432^1,2		--	241065905(+)	`TCTCTA/GCACAC`	1	--	ds500¹		0	--	--	--	--
rs138915136^1,2	F	--	241066037(+)	`GCAACG/AGATGG`	2	/S	syn¹		1		NA	4550
rs201508038^1,2	C	--	241066049(+)	`GTTTCA/CTCACT`	2	E D	mis¹		0	--	--	--	--
rs114131179^1,2		--	241066058(+)	`CTCTTA/GAAACA`	2	F	syn¹		1		NA	214
rs202053233^1,2		--	241066069(+)	`TTTACC/TCCTCC`	2	S G	mis¹		0	--	--	--	--
rs146329964^1,2	C,F	--	241066093(+)	`TGATAT/GTGTGC`	2	/I /L	mis¹		1		NA	4550

HapMap Linkage Disequilibrium report for MYEOV2 (241065980 - 241076224 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MYEOV2
1 CNV: 0031

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MYEOV2 for disorders About GeneDecksing

1 disease for MYEOV2: About MalaCards

myeloma

Human Genome Epidemiology (HuGE) Navigator: MYEOV2 (1 document)

Export disorders for MYEOV2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MYEOV2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MYEOV2)

Utopia: connect your pdf to the dynamic
world of online information

A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)¹ Bennett E.J....Harper J.W. (2010)
Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)¹ Sowa M.E....Harper J.W. (2009)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)¹ Brandenberger R.... Stanton L.W. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 150678	HGNC: 21314	AceView: LOC150678	Ensembl:ENSG00000172428	euGenes: HUgn150678
ECgene: MYEOV2	H-InvDB: MYEOV2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MYEOV2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MYEOV2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MYEOV2 gene:
Search GeneIP for patents involving MYEOV2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MYEOV2 gene at Home site.

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MYEOV2 Gene

myeloma overexpressed 2

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Export list of displayed genes

MYEOV2 Gene

myeloma overexpressed 2

Aliasesfor MYEOV2 gene

Summariesfor MYEOV2 gene

Genomic Viewsfor MYEOV2 gene

Proteinsfor MYEOV2 gene

Protein Domains /Familiesfor MYEOV2 gene

Functionfor MYEOV2 gene

Pathways & Interactionsfor MYEOV2 gene

Drugs & Compoundsfor MYEOV2 gene

Transcriptsfor MYEOV2 gene

Expression for MYEOV2 gene

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Genomic Variantsfor MYEOV2 gene

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Genome Databases showing MYEOV2 gene

Other Databases showing MYEOV2 gene

Specialized Databases showing MYEOV2 gene

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Aliases
for MYEOV2 gene

Summaries
for MYEOV2 gene

Genomic Views
for MYEOV2 gene

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for MYEOV2 gene

Protein Domains /
Families
for MYEOV2 gene

Function
for MYEOV2 gene

Pathways & Interactions
for MYEOV2 gene

Drugs & Compounds
for MYEOV2 gene

Transcripts
for MYEOV2 gene

Expression
for MYEOV2 gene

Orthologs
for MYEOV2 gene

Paralogs
for MYEOV2 gene

Genomic Variants
for MYEOV2 gene

Disorders / Diseases
for MYEOV2 gene

Publications
for MYEOV2 gene

Intellectual Property
for MYEOV2 gene

Products
for MYEOV2 gene