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MYEOV2 Gene

protein-coding   GIFtS: 40
GCID: GC02M241065

Myeloma Overexpressed 2

  See MYEOV2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myeloma Overexpressed 21 2
Helicase/Primase Complex Protein2
Myeloma-Overexpressed Gene 2 Protein2

External Ids:    HGNC: 213141   Entrez Gene: 1506782   Ensembl: ENSG000001724287   UniProtKB: Q8WXC63   

Export aliases for MYEOV2 gene to outside databases

Previous GC identifers: GC02M240786 GC02M232823


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MYEOV2 Gene:
MYEOV2 (myeloma overexpressed 2) is a protein-coding gene. Diseases associated with MYEOV2 include myeloma.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the MYEOV2 gene promoter:
         PPAR-gamma1   Lmo2   Hand1   AP-4   PPAR-gamma2   ATF   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMYEOV2 promoter sequence
   Search Chromatin IP Primers for MYEOV2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MYEOV2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

MYEOV2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYEOV2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M241065:  view genomic region     (about GC identifiers)

Start:
241,065,980 bp from pter      End:
241,076,224 bp from pter
Size:
10,245 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MYOV2_HUMAN, Q8WXC6 (See protein sequence)
Recommended Name: Myeloma-overexpressed gene 2 protein  
Size: 57 amino acids; 6211 Da
Secondary accessions: Q8N110
Alternative splicing: 2 isoforms:  Q8WXC6-2   Q8WXC6-1   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MYEOV2: NX_Q8WXC6

Explore proteomics data for MYEOV2 at MOPED


See MYEOV2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001156896.1  NP_612209.1  

ENSEMBL proteins: 
 ENSP00000304147   ENSP00000475979   ENSP00000383946  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q8WXC6

UniProtKB/Swiss-Prot: MYOV2_HUMAN, Q8WXC6
Similarity: Belongs to the MYEOV2 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus2
cytosol1
extracellular1
mitochondrion1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MYEOV2
Interactions:

    Search GeneGlobe Interaction Network for MYEOV2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for MYEOV2 (Q8WXC63 ENSP000003041474) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
COPS6Q7L5N13, ENSP000003041024I2D: score=2 STRING: ENSP00000304102
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MYEOV2 (MYOV2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MYEOV2 gene (2 alternative transcripts): 
NM_001163424.1  NM_138336.1  

Unigene Cluster for MYEOV2:

Myeloma overexpressed 2
Hs.293884  [show with all ESTs]
Unigene Representative Sequence: AK126809
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000307266(uc002vyu.1) ENST00000607357 ENST00000491765 ENST00000489698
ENST00000403160(uc010zof.1)
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Additional mRNA sequence: 

AF453951.1 AF487338.1 AK126809.1 BC033955.2 

5 DOTS entries:

DT.444819  DT.100786524  DT.97785314  DT.97842239  DT.97842241 

Selected AceView cDNA sequences (see all 122):

AW963401 BE876673 AI373698 AI650587 BM451552 AW163689 BQ025380 AW207312 
AI872187 BI754824 AW163088 BM768333 AK126809 AI347461 AF453951 AJ708690 
BG319561 BQ023707 NM_138336 AI891108 CB069641 AA371861 F28544 AI344634 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for MYEOV2    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1:                    -                 -               
SP2:              -     -                                 
SP3:                                                      


ECgene alternative splicing isoforms for MYEOV2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MYEOV2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAGACTTTTT
MYEOV2 Expression
About this image


MYEOV2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 17) fully expand
 
 Brain (Nervous System)
         Cerebral Cortex
 
 Colon (Gastrointestinal Tract)
 
 Uterus (Reproductive System)
 
 Thyroid (Endocrine System)
 
 Testis (Reproductive System)
MYEOV2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MYEOV2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.293884
    Custom PCR Arrays for MYEOV2
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MYEOV2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for MYEOV2 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Myeov21 , 5 myeloma overexpressed 21, 5 90.64(n)1
98.25(a)1
  1 (46.55 cM)5
669151  NM_001163425.11  NP_001156897.11 
 926371455 
chicken
(Gallus gallus)
Aves MYEOV21 myeloma overexpressed 2 87.13(n)
100(a)
  770635  NM_001277705.1  NP_001264634.1 
lizard
(Anolis carolinensis)
Reptilia MYEOV26
myeloma overexpressed 2
79(a)
1 ↔ 1
3(28758330-28762354)
tropical clawed frog
(Xenopus tropicalis)
Amphibia myeov21 myeloma overexpressed 2 83.04(n)
98.25(a)
  448732  NM_001005143.1  NP_001005143.1 
zebrafish
(Danio rerio)
Actinopterygii zgc778082 hypothetical protein MGC77808 80(n)   393820  BC062283.1 
fruit fly
(Drosophila melanogaster)
Insecta CG170596
--
46(a)
1 ↔ 1
2R(9107788-9108520)


ENSEMBL Gene Tree for MYEOV2 (if available)
TreeFam Gene Tree for MYEOV2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MYEOV2 gene

Find genes that share paralogs with MYEOV2           About GenesLikeMe


1 Pseudogenes.org Pseudogene for MYEOV2
PGOHUM00000247802


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MYEOV2 (see all 332)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs76050401,2
C,A--241065548(+) ctttgC/Ggaaat 1 -- ds50010--------
rs1817415681,2
--241065585(+) CAGGGA/CTCCTT 1 -- ds50010--------
rs764296221,2
C--241065709(+) GTGTGT/CGGCCA 1 -- ds50012Minor allele frequency- C:0.13NA EA 122
rs1147433781,2
F--241065747(+) ACTCCG/ATGATA 1 -- ds50011Minor allele frequency- A:0.02WA 118
rs1385754321,2
--241065905(+) TCTCTA/GCACAC 1 -- ds50010--------
rs1389151361,2
F--241066037(+) GCAACG/AGATGG 2 /S syn11Minor allele frequency- A:0.00NA 4550
rs2015080381,2
C--241066049(+) GTTTCA/CTCACT 2 E D mis10--------
rs1141311791,2
C--241066058(+) CTCTTA/GAAACA 2 F syn11Minor allele frequency- G:0.01NA 214
rs2020532331,2
C--241066069(+) TTTACC/TCCTCC 2 S G mis10--------
rs2016944571,2
C--241066081(+) GTGAGT/CAGAAA 2 /T /A mis11Minor allele frequency- C:0.00EU 1323

HapMap Linkage Disequilibrium report for MYEOV2 (241065980 - 241076224 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for MYEOV2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv483047CNV Loss15286789
nsv876099CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for MYEOV2:    
About MalaCards
myeloma


Find genes that share disorders with MYEOV2           About GenesLikeMe

Human Genome Epidemiology (HuGE) Navigator: MYEOV2 (1 document)

Export disorders for MYEOV2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MYEOV2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MYEOV2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification. (PubMed id 23776465)1 Ebina M....Chiba T. (PLoS ONE 2013)
  2. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
  4. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
  6. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  8. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 150678 HGNC: 21314 AceView: LOC150678 Ensembl:ENSG00000172428 euGenes: HUgn150678
ECgene: MYEOV2 H-InvDB: MYEOV2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MYEOV2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MYEOV2 gene:
Search GeneIP for patents involving MYEOV2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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